Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	HOXA3 POU3F2 IRX1 ATOH1 EN1 MYRF FOXG1 YLPM1 FOXC2	3.12e-05	1412	25	9	GO:0000981
GeneOntologyMolecularFunction	chromatin binding	TRIM66 SFPQ RERE ATOH1 ATXN7 FOXC2	2.44e-04	739	25	6	GO:0003682
GeneOntologyMolecularFunction	HMG box domain binding	HOXA3 POU3F2	3.75e-04	23	25	2	GO:0071837
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	TRIM66 SFPQ MAGEL2 IRX1 RERE EN1 FOXG1 YLPM1 FOXC2	2.24e-05	1399	25	9	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	TRIM66 SFPQ MAGEL2 IRX1 RERE EN1 FOXG1 YLPM1 FOXC2	2.42e-05	1413	25	9	GO:1902679
GeneOntologyBiologicalProcess	neuron fate determination	ATOH1 FOXG1	7.71e-05	11	25	2	GO:0048664
GeneOntologyBiologicalProcess	embryonic morphogenesis	HOXA3 IRX1 ATOH1 EN1 FOXG1 FOXC2	1.69e-04	713	25	6	GO:0048598
GeneOntologyBiologicalProcess	neuron fate commitment	POU3F2 ATOH1 FOXG1	1.78e-04	91	25	3	GO:0048663
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	SFPQ MAGEL2 IRX1 EN1 FOXG1 YLPM1 FOXC2	1.89e-04	1053	25	7	GO:0000122
GeneOntologyBiologicalProcess	regionalization	HOXA3 IRX1 EN1 FOXG1 FOXC2	2.37e-04	478	25	5	GO:0003002
GeneOntologyBiologicalProcess	pattern specification process	HOXA3 IRX1 EN1 FOXG1 FOXC2	3.68e-04	526	25	5	GO:0007389
GeneOntologyCellularComponent	chromatin	HOXA3 TRIM66 POU3F2 SFPQ IRX1 ATOH1 EN1 ATXN7 FOXG1 FOXC2	3.75e-06	1480	25	10	GO:0000785
GeneOntologyCellularComponent	nuclear body	CBLL1 DOCK1 ACIN1 SFPQ RERE YLPM1 FOXC2	6.65e-05	903	25	7	GO:0016604
GeneOntologyCellularComponent	nuclear speck	CBLL1 DOCK1 ACIN1 SFPQ YLPM1	1.38e-04	431	25	5	GO:0016607
MousePheno	blepharoptosis	ATXN7 EFEMP2 FOXC2	5.87e-06	22	23	3	MP:0001344
MousePheno	perinatal lethality, complete penetrance	HOXA3 IRX1 RERE ATOH1 EN1 FOXG1 EFEMP2 FOXC2	1.08e-05	712	23	8	MP:0011089
MousePheno	perinatal lethality	HOXA3 MAGEL2 IRX1 RERE ATOH1 EN1 FOXG1 EFEMP2 FOXC2	4.12e-05	1130	23	9	MP:0002081
MousePheno	lethality during fetal growth through weaning, complete penetrance	HOXA3 POU3F2 IRX1 RERE ATOH1 EN1 FOXG1 EFEMP2 FOXC2	1.03e-04	1269	23	9	MP:0011111
MousePheno	abnormal soft palate morphology	HOXA3 FOXC2	1.16e-04	10	23	2	MP:0003154
MousePheno	abnormal aorta morphology	HOXA3 RERE EFEMP2 FOXC2	4.55e-04	225	23	4	MP:0000272
MousePheno	cyanosis	DOCK1 IRX1 ATOH1 FOXG1	4.63e-04	226	23	4	MP:0001575
MousePheno	abnormal facial morphology	HOXA3 DOCK1 SFPQ IRX1 RERE FOXG1 FOXC2	4.71e-04	910	23	7	MP:0003743
MousePheno	abnormal craniofacial development	HOXA3 IRX1 RERE FOXG1 FOXC2	5.43e-04	425	23	5	MP:0003935
MousePheno	abnormal fourth pharyngeal arch morphology	HOXA3 FOXC2	6.42e-04	23	23	2	MP:0006340
MousePheno	atelectasis	DOCK1 IRX1 FOXC2	7.10e-04	108	23	3	MP:0001177
MousePheno	abnormal pulmonary alveolus morphology	DOCK1 IRX1 EFEMP2 FOXC2	7.29e-04	255	23	4	MP:0002270
MousePheno	abnormal oxygen level	DOCK1 IRX1 ATOH1 FOXG1	7.39e-04	256	23	4	MP:0001574
MousePheno	abnormal neuron number	POU3F2 ATOH1 EN1 ATXN7 FOXG1	7.47e-04	456	23	5	MP:0008946
MousePheno	abnormal pulmonary acinus morphology	DOCK1 IRX1 EFEMP2 FOXC2	1.09e-03	284	23	4	MP:0010911
MousePheno	aphagia	MAGEL2 IRX1 EN1	1.19e-03	129	23	3	MP:0001438
MousePheno	decreased brain size	RERE EN1 ATXN7 FOXG1	1.25e-03	295	23	4	MP:0000774
MousePheno	abnormal pulmonary alveolar system morphology	DOCK1 IRX1 EFEMP2 FOXC2	1.27e-03	296	23	4	MP:0010899
MousePheno	abnormal thoracic aorta morphology	RERE EFEMP2 FOXC2	1.33e-03	134	23	3	MP:0010468
MousePheno	abnormal breathing pattern	IRX1 ATOH1 FOXG1 EFEMP2	1.38e-03	303	23	4	MP:0001951
MousePheno	abnormal systemic artery morphology	HOXA3 RERE EFEMP2 FOXC2	1.40e-03	304	23	4	MP:0011655
MousePheno	neonatal lethality	HOXA3 IRX1 ATOH1 EN1 FOXG1 EFEMP2	1.49e-03	799	23	6	MP:0002058
MousePheno	neonatal lethality, complete penetrance	IRX1 ATOH1 EN1 FOXG1 EFEMP2	1.52e-03	534	23	5	MP:0011087
MousePheno	abnormal axial skeleton morphology	HOXA3 DOCK1 MAGEL2 IRX1 EN1 ATXN7 FOXG1 FOXC2	1.60e-03	1458	23	8	MP:0002114
MousePheno	abnormal head morphology	HOXA3 DOCK1 SFPQ IRX1 RERE FOXG1 FOXC2	1.62e-03	1120	23	7	MP:0000432
MousePheno	abnormal cerebellum vermis morphology	EN1 ATXN7	1.67e-03	37	23	2	MP:0000864
Domain	Homeodomain-like	HOXA3 POU3F2 IRX1 RERE EN1	6.83e-05	332	25	5	IPR009057
Domain	Homeobox_CS	HOXA3 POU3F2 IRX1 EN1	1.02e-04	186	25	4	IPR017970
Domain	Homeobox	HOXA3 POU3F2 IRX1 EN1	2.47e-04	234	25	4	PF00046
Domain	HOMEOBOX_1	HOXA3 POU3F2 IRX1 EN1	2.55e-04	236	25	4	PS00027
Domain	HOX	HOXA3 POU3F2 IRX1 EN1	2.59e-04	237	25	4	SM00389
Domain	Homeobox_dom	HOXA3 POU3F2 IRX1 EN1	2.68e-04	239	25	4	IPR001356
Domain	HOMEOBOX_2	HOXA3 POU3F2 IRX1 EN1	2.68e-04	239	25	4	PS50071
Domain	-	HOXA3 POU3F2 IRX1 EN1	5.08e-04	283	25	4	1.10.10.60
Domain	TF_fork_head_CS_2	FOXG1 FOXC2	1.72e-03	46	25	2	IPR030456
Domain	TF_fork_head_CS_1	FOXG1 FOXC2	1.79e-03	47	25	2	IPR018122
Domain	FORK_HEAD_3	FOXG1 FOXC2	1.95e-03	49	25	2	PS50039
Domain	FH	FOXG1 FOXC2	1.95e-03	49	25	2	SM00339
Domain	FORK_HEAD_1	FOXG1 FOXC2	1.95e-03	49	25	2	PS00657
Domain	FORK_HEAD_2	FOXG1 FOXC2	1.95e-03	49	25	2	PS00658
Domain	Forkhead	FOXG1 FOXC2	1.95e-03	49	25	2	PF00250
Domain	Fork_head_dom	FOXG1 FOXC2	1.95e-03	49	25	2	IPR001766
Domain	RRM	ACIN1 SFPQ RBM33	2.95e-03	217	25	3	SM00360
Domain	RRM_dom	ACIN1 SFPQ RBM33	3.34e-03	227	25	3	IPR000504
Domain	HTH_motif	HOXA3 EN1	3.82e-03	69	25	2	IPR000047
Domain	-	ACIN1 SFPQ RBM33	4.10e-03	244	25	3	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	ACIN1 SFPQ RBM33	4.79e-03	258	25	3	IPR012677
Domain	Homeobox_metazoa	HOXA3 EN1	6.41e-03	90	25	2	IPR020479
Pubmed	A census of human transcription factors: function, expression and evolution.	HOXA3 POU3F2 IRX1 RERE ATOH1 EN1 MYRF FOXG1 FOXC2	7.60e-09	908	25	9	19274049
Pubmed	Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.	HOXA3 ATOH1 FOXG1	1.83e-07	16	25	3	33475140
Pubmed	Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development.	POU3F2 ATOH1 EN1	2.66e-07	18	25	3	23459943
Pubmed	Novel roles of hakai in cell proliferation and oncogenesis.	CBLL1 SFPQ	4.96e-07	2	25	2	19535458
Pubmed	Conditional loss of Engrailed1/2 in Atoh1-derived excitatory cerebellar nuclear neurons impairs eupneic respiration in mice.	ATOH1 EN1	1.49e-06	3	25	2	35044072
Pubmed	Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo.	ATOH1 FOXG1	1.49e-06	3	25	2	22573692
Pubmed	Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors.	ATOH1 EN1	1.49e-06	3	25	2	16202705
Pubmed	Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons.	ATOH1 EN1	1.49e-06	3	25	2	34542409
Pubmed	Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins.	HOXA3 EN1	1.49e-06	3	25	2	8096059
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	POU3F2 IRX1 ATOH1 EN1 FOXG1 FOXC2	1.96e-06	544	25	6	28473536
Pubmed	Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.	IRX1 EN1 FOXG1	2.31e-06	36	25	3	18094027
Pubmed	Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear.	ATOH1 FOXG1	2.97e-06	4	25	2	16691564
Pubmed	Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern.	ATOH1 EN1	2.97e-06	4	25	2	27609139
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	ACIN1 SFPQ RBM33 YLPM1	3.72e-06	148	25	4	32538781
Pubmed	Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides.	EN1 FOXG1	4.95e-06	5	25	2	18611861
Pubmed	A causative link between inner ear defects and long-term striatal dysfunction.	EN1 FOXG1	4.95e-06	5	25	2	24009395
Pubmed	Misexpression of Gbx2 throughout the mesencephalon by a conditional gain-of-function transgene leads to deletion of the midbrain and cerebellum in mice.	ATOH1 EN1	4.95e-06	5	25	2	19603509
Pubmed	Sp8 is crucial for limb outgrowth and neuropore closure.	EN1 FOXG1	7.43e-06	6	25	2	14526104
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	SFPQ CKAP4 RBM33 YLPM1	8.42e-06	182	25	4	32239614
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	IRX1 ATOH1 EN1 FOXC2	1.02e-05	191	25	4	24146773
Pubmed	Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development.	HOXA3 FOXG1	1.04e-05	7	25	2	16284121
Pubmed	The Transcription Factor Pou3f1 Sheds Light on the Development and Molecular Diversity of Glutamatergic Cerebellar Nuclear Neurons in the Mouse.	POU3F2 ATOH1	1.39e-05	8	25	2	35935334
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ACIN1 SFPQ RERE YLPM1	1.78e-05	220	25	4	35785414
Pubmed	Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip.	ATOH1 EN1	1.78e-05	9	25	2	17319963
Pubmed	Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.	ATOH1 EN1	1.78e-05	9	25	2	28392070
Pubmed	Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression.	POU3F2 FOXG1	1.78e-05	9	25	2	18065723
Pubmed	ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain.	POU3F2 FOXG1	1.78e-05	9	25	2	25395668
Pubmed	LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.	ATOH1 EN1	1.78e-05	9	25	2	17664423
Pubmed	The isthmic neuroepithelium is essential for cerebellar midline fusion.	ATOH1 EN1	2.22e-05	10	25	2	14507778
Pubmed	Spatiotemporal expression patterns of clusterin in the mouse inner ear.	ATOH1 FOXG1	2.22e-05	10	25	2	28687930
Pubmed	Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.	EN1 FOXG1	2.22e-05	10	25	2	11731459
Pubmed	Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice.	ATOH1 EN1	2.72e-05	11	25	2	29972353
Pubmed	The homeobox containing gene Lbx1 is required for correct dorsal-ventral patterning of the neural tube.	ATOH1 EN1	2.72e-05	11	25	2	12358782
Pubmed	Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.	ATOH1 FOXG1	2.72e-05	11	25	2	29139542
Pubmed	Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.	FOXG1 FOXC2	2.72e-05	11	25	2	7683413
Pubmed	Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer.	EN1 FOXG1	3.26e-05	12	25	2	16530751
Pubmed	Reciprocal Negative Regulation Between Lmx1a and Lmo4 Is Required for Inner Ear Formation.	ATOH1 FOXG1	3.26e-05	12	25	2	29769265
Pubmed	Conditional gene expression in the mouse inner ear using Cre-loxP.	ATOH1 FOXG1	3.26e-05	12	25	2	22526732
Pubmed	CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus.	ATOH1 FOXG1	3.26e-05	12	25	2	30008200
Pubmed	Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding.	ATOH1 EN1	3.26e-05	12	25	2	10952903
Pubmed	Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells.	ATOH1 FOXG1	3.26e-05	12	25	2	23918393
Pubmed	Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.	SFPQ EN1	3.85e-05	13	25	2	19144721
Pubmed	Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.	EN1 FOXG1	3.85e-05	13	25	2	20941375
Pubmed	Retinoic acid from the meninges regulates cortical neuron generation.	POU3F2 FOXC2	3.85e-05	13	25	2	19879845
Pubmed	A medullary centre for lapping in mice.	ATOH1 FOXG1	3.85e-05	13	25	2	34728601
Pubmed	Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.	EN1 FOXG1	4.49e-05	14	25	2	9811592
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ACIN1 SFPQ RBM33 YLPM1	4.74e-05	283	25	4	30585729
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CBLL1 ACIN1 SFPQ CKAP4 RBM33 YLPM1	4.75e-05	954	25	6	36373674
Pubmed	EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development.	ATOH1 FOXG1	5.18e-05	15	25	2	38176908
Pubmed	Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression.	MAGEL2 FOXG1	5.18e-05	15	25	2	23523356
Pubmed	A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.	ATOH1 EN1	5.18e-05	15	25	2	27414798
Pubmed	Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.	EN1 FOXG1	5.92e-05	16	25	2	21925158
Pubmed	Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.	ATOH1 FOXG1	5.92e-05	16	25	2	8543157
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	POU3F2 EN1	5.92e-05	16	25	2	19527706
Pubmed	The zinc-finger protein CNBP is required for forebrain formation in the mouse.	EN1 FOXG1	5.92e-05	16	25	2	12588852
Pubmed	Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region.	EN1 FOXG1	5.92e-05	16	25	2	22627282
Pubmed	Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system.	ATOH1 EN1	5.92e-05	16	25	2	16728479
Pubmed	Stalled replication forks within heterochromatin require ATRX for protection.	POU3F2 FOXG1	5.92e-05	16	25	2	27171262
Pubmed	SMAD4 is essential for generating subtypes of neurons during cerebellar development.	ATOH1 EN1	6.70e-05	17	25	2	22370000
Pubmed	Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types.	POU3F2 EN1	6.70e-05	17	25	2	21431469
Pubmed	FGFR1 is required for the development of the auditory sensory epithelium.	ATOH1 FOXG1	6.70e-05	17	25	2	12194867
Pubmed	Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.	ATOH1 EN1	6.70e-05	17	25	2	16571630
Pubmed	A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.	EN1 FOXG1	6.70e-05	17	25	2	12361972
Pubmed	Increased β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics.	EN1 FOXG1	6.70e-05	17	25	2	22102609
Pubmed	A threshold requirement for Gbx2 levels in hindbrain development.	ATOH1 EN1	6.70e-05	17	25	2	16651541
Pubmed	A method to identify cDNAs based on localization of green fluorescent protein fusion products.	ACIN1 YLPM1	6.70e-05	17	25	2	10716735
Pubmed	Tcf3: a transcriptional regulator of axis induction in the early embryo.	EN1 FOXG1	7.54e-05	18	25	2	14668413
Pubmed	The graded response to Sonic Hedgehog depends on cilia architecture.	ATOH1 EN1	7.54e-05	18	25	2	17488627
Pubmed	N-myc controls proliferation, morphogenesis, and patterning of the inner ear.	ATOH1 FOXG1	7.54e-05	18	25	2	21562282
Pubmed	Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.	ATOH1 EN1	7.54e-05	18	25	2	17166916
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	ATXN7 EFEMP2 YLPM1	8.29e-05	118	25	3	21078624
Pubmed	Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.	HOXA3 FOXG1	8.42e-05	19	25	2	25249461
Pubmed	Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models.	ATOH1 FOXG1	9.35e-05	20	25	2	33382037
Pubmed	CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.	EN1 FOXG1	9.35e-05	20	25	2	17067568
Pubmed	Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.	EN1 FOXG1	9.35e-05	20	25	2	9790191
Pubmed	Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.	IRX1 FOXG1	9.35e-05	20	25	2	16971467
Pubmed	FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.	ATOH1 FOXG1	9.35e-05	20	25	2	24465223
Pubmed	Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer.	HOXA3 FOXG1	9.35e-05	20	25	2	33277484
Pubmed	Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms.	ATOH1 EN1	1.03e-04	21	25	2	17321515
Pubmed	Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.	ATOH1 EN1	1.03e-04	21	25	2	11500373
Pubmed	Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.	POU3F2 FOXG1	1.03e-04	21	25	2	31680852
Pubmed	Embryo model completes gastrulation to neurulation and organogenesis.	EN1 FOXG1	1.14e-04	22	25	2	36007540
Pubmed	Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.	ATOH1 EN1	1.14e-04	22	25	2	21693512
Pubmed	Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo.	EN1 FOXG1	1.14e-04	22	25	2	16678814
Pubmed	Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.	CKAP4 EFEMP2	1.14e-04	22	25	2	30089695
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	ACIN1 SFPQ PDE4D YLPM1	1.18e-04	358	25	4	32460013
Pubmed	Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.	EN1 FOXG1	1.24e-04	23	25	2	20089898
Pubmed	BMP signalling inhibits premature neural differentiation in the mouse embryo.	EN1 FOXG1	1.36e-04	24	25	2	17699604
Pubmed	Rbpj regulates development of prosensory cells in the mammalian inner ear.	ATOH1 FOXG1	1.36e-04	24	25	2	21420948
Pubmed	Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.	ATOH1 EN1	1.36e-04	24	25	2	24946904
Pubmed	Emx2 directs the development of diencephalon in cooperation with Otx2.	EN1 FOXG1	1.36e-04	24	25	2	11493561
Pubmed	Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube.	ATOH1 EN1	1.36e-04	24	25	2	20960561
Pubmed	Continued expression of GATA3 is necessary for cochlear neurosensory development.	ATOH1 FOXG1	1.36e-04	24	25	2	23614009
Pubmed	LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.	ACIN1 SFPQ CKAP4	1.43e-04	142	25	3	30809309
Pubmed	Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord.	ATOH1 EN1	1.47e-04	25	25	2	15469980
Pubmed	Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.	ATOH1 EN1	1.47e-04	25	25	2	21307096
Pubmed	A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.	POU3F2 FOXG1	1.60e-04	26	25	2	26651292
Pubmed	Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.	POU3F2 ATOH1	1.60e-04	26	25	2	30538199
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CBLL1 SFPQ RERE CKAP4 RBM33 FOXG1	1.70e-04	1203	25	6	29180619
Pubmed	Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.	ATOH1 EN1	1.72e-04	27	25	2	18480159
GeneFamily	Forkhead boxes	FOXG1 FOXC2	9.21e-04	43	19	2	508
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SFPQ YLPM1	1.52e-02	181	19	2	694
GeneFamily	RNA binding motif containing	SFPQ RBM33	2.07e-02	213	19	2	725
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SFPQ IRX1 FNTA MYRF	2.29e-06	169	25	4	50cc0f5a022b95986949db63208a627cef9f4a69
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SFPQ IRX1 FNTA EN1	2.81e-06	178	25	4	b1357ceb84b83fab53c0394c1af73cbd009f571a
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CBLL1 POU3F2 PDE4D	9.76e-05	161	25	3	2849fbc9611af208241b33da3cd18290aafe426b
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXA3 DOCK1 FOXC2	1.05e-04	165	25	3	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SFPQ IRX1 MYRF	1.07e-04	166	25	3	a7ac5a414e3e2ff01f1c452c0a85048b17cba0b6
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK1 EN1 MYRF	1.40e-04	182	25	3	d524ad5cf00f05ee27c9db2ffa2d4e30a1e2e21a
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TRIM66 IQSEC3 MAGEL2	1.40e-04	182	25	3	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CKAP4 FOXG1 EFEMP2	1.54e-04	188	25	3	b382d18fb09fb2869f3c151efa71540a7f5ed229
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DOCK1 PDE4D RERE	1.54e-04	188	25	3	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 PDE4D RERE	1.57e-04	189	25	3	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	(5)_Epi_basal\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	IRX1 EFEMP2 FOXC2	1.62e-04	191	25	3	6bda3d5a8a391d41bb4d65872492e6c094bcc4d4
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CKAP4 FOXG1 EFEMP2	1.64e-04	192	25	3	f053b89bfd6048c227667ff01c38df7c51d8a496
ToppCell	facs-Diaphragm\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 EN1 FOXG1	1.64e-04	192	25	3	486cbf9791ca619e307e8b18aa70ce22111f4f26
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D RERE RBM33	1.64e-04	192	25	3	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D RERE RBM33	1.67e-04	193	25	3	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKAP4 EN1 EFEMP2	1.67e-04	193	25	3	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKAP4 EN1 EFEMP2	1.67e-04	193	25	3	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	POU3F2 IRX1 FOXG1	1.69e-04	194	25	3	08fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 PDE4D RERE	1.74e-04	196	25	3	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	wk_20-22-Epithelial-Distal_epithelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IRX1 RBBP8NL MYRF	1.74e-04	196	25	3	cd507ee2baf4f52d6498811b3510d3164b56311f
ToppCell	wk_15-18-Epithelial-Distal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IRX1 RBBP8NL MYRF	1.77e-04	197	25	3	b7aff83c27606d87565382a768119a863fe1c294
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOXA3 MYRF EFEMP2	1.80e-04	198	25	3	35edf6d5bedc2181fbdd56f43e458bc39f4eca16
ToppCell	Biopsy_Other_PF-Epithelial-MUC5AC+_High\|Biopsy_Other_PF / Sample group, Lineage and Cell type	IRX1 RBBP8NL FAM83A	1.80e-04	198	25	3	30e6177e216f66caddcd009fafef0e07369f4d8e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOXA3 MYRF EFEMP2	1.80e-04	198	25	3	ff6d9455ebfe965cc6f48197172c0ebd3bddde81
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 PDE4D RERE	1.80e-04	198	25	3	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOXA3 MYRF EFEMP2	1.80e-04	198	25	3	5cfd1c030c0940136a397b5a4b5d6ecbaecf72eb
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOXA3 MYRF EFEMP2	1.80e-04	198	25	3	5375a2895cf995f0db4a61861093f01794707901
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 PDE4D RERE	1.82e-04	199	25	3	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 PDE4D FOXG1	1.85e-04	200	25	3	8795920911ee75c09a97cc948c14ad7301b27796
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	POU3F2 FOXG1 EFEMP2	1.85e-04	200	25	3	4c20102de2ff7a38e5bff5c65e9fbd0d0310a302
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ACIN1 SFPQ RBM33	1.85e-04	200	25	3	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	neurotic disorder	PDE4D RERE YLPM1	8.48e-05	101	25	3	EFO_0004257
Disease	DiGeorge syndrome (implicated_via_orthology)	HOXA3 DOCK1	1.17e-04	19	25	2	DOID:11198 (implicated_via_orthology)
Disease	Moyamoya disease	DOCK1 MYRF	5.27e-04	40	25	2	MONDO_0016820
Disease	cholesteryl ester 20:5 measurement	CKAP4 MYRF	6.38e-04	44	25	2	EFO_0010349
Disease	nervous system disorder	EN1 FOXG1	9.25e-04	53	25	2	C0027765
Disease	basophil measurement	RERE CKAP4	1.18e-03	60	25	2	EFO_0803539
Disease	Arsenic Induced Polyneuropathy	SFPQ ATXN7	1.26e-03	62	25	2	C0751852
Disease	Arsenic Encephalopathy	SFPQ ATXN7	1.26e-03	62	25	2	C0751851
Disease	Arsenic Poisoning	SFPQ ATXN7	1.26e-03	62	25	2	C0311375
Disease	Arsenic Poisoning, Inorganic	SFPQ ATXN7	1.26e-03	62	25	2	C0274861
Disease	Nervous System, Organic Arsenic Poisoning	SFPQ ATXN7	1.26e-03	62	25	2	C0274862
Disease	age at menarche	TRIM66 POU3F2 PDE4D RERE	1.47e-03	594	25	4	EFO_0004703
Disease	pentachlorophenol measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022071
Disease	parathion measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022070
Disease	potassium chromate measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022072
Disease	mercuric chloride measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022068
Disease	heptachlor epoxide measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022067
Disease	methoxychlor measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022052
Disease	azinphos methyl measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022055
Disease	aldrin measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022054
Disease	dicofol measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022060
Disease	disulfoton measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022062
Disease	dieldrin measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022061
Disease	endrin measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022064
Disease	endosulfan measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022063
Disease	heptachlor measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022066
Disease	ethion measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022065
Disease	chlorpyrifos measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022057
Disease	cadmium chloride measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022056
Disease	diazinon measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022059
Disease	dibutyl phthalate measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0022058
Disease	environmental exposure measurement	PDE4D RBBP8NL	1.75e-03	73	25	2	EFO_0008360

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLHPPPPPPVQPPQH	ACIN1	1116	Q9UKV3
PPPAPQQPPPPPAPH	CKAP4	36	Q07065
PLHPPLPPPHQPQPQ	RBM33	581	Q96EV2
HPPPPGTPMVHPPPP	MAGEL2	171	Q9UJ55
HPPPPQAAPPAPQPP	HOXA3	91	O43365
HHPPPPAPQPPPPPQ	FOXG1	56	P55316
HLPPPPPPSPQPQPQ	PDE4D	56	Q08499
PHPPPPPRFQPHQGP	FAM83A	361	Q86UY5
HPQAPPPPPAPQPQP	FOXC2	396	Q99958
HPHLPPHPPPPPPQH	EN1	71	Q05925
QPPLPPPPPPYNHPH	IQSEC3	1146	Q9UPP2
PPPQPQRQQHPPPPP	ATXN7	41	O15265
PPPPPISHPMPHPPQ	CBLL1	346	Q75N03
RPLPPPHPQPPPHPQ	RBBP8NL	536	Q8NC74
PHPQPPPHPQPPDLD	RBBP8NL	541	Q8NC74
PPPPPPHQRHLPPPL	DOCK1	1826	Q14185
RQPQPHHLPQPPPPP	ATOH1	21	Q92858
PPPPVPPAQHPNPCP	EFEMP2	96	O95967
PHGPHLPAPPPPQPP	IRX1	401	P78414
PGQPAQPPPQPHPPP	FNTA	16	P49354
PPSPHPPPHPSPHPP	RERE	811	Q9P2R6
PHSHPHQQPPPPPPP	POU3F2	231	P20265
QPPPQQPPPHQPPPH	SFPQ	76	P23246
LQPHHLPPPPLPPPP	YLPM1	76	P49750
HPPPPLPPPPQQPHP	TRIM66	466	O15016
EHPPPPPAHLPGPPP	MYRF	176	Q9Y2G1