Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionthreonine-tRNA ligase activity

TARS1 TARS3

2.86e-063202GO:0004829
GeneOntologyMolecularFunctionprotein transporter activity

LRP2 SEC61A1 SEC61A2

9.62e-0642203GO:0140318
GeneOntologyMolecularFunctionprotein transmembrane transporter activity

SEC61A1 SEC61A2

3.55e-0428202GO:0008320
GeneOntologyMolecularFunctionmacromolecule transmembrane transporter activity

SEC61A1 SEC61A2

5.25e-0434202GO:0022884
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

TARS1 TARS3

8.01e-0442202GO:0004812
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

TARS1 TARS3

8.01e-0442202GO:0016875
GeneOntologyMolecularFunctionsignal sequence binding

SEC61A1 SEC61A2

1.18e-0351202GO:0005048
GeneOntologyBiologicalProcessthreonyl-tRNA aminoacylation

TARS1 TARS3

2.41e-063192GO:0006435
GeneOntologyBiologicalProcessSRP-dependent cotranslational protein targeting to membrane, translocation

SEC61A1 SEC61A2

2.24e-058192GO:0006616
GeneOntologyBiologicalProcesspost-translational protein targeting to membrane, translocation

SEC61A1 SEC61A2

2.24e-058192GO:0031204
GeneOntologyBiologicalProcessenteric nervous system development

SLC6A4 SOX8

7.27e-0514192GO:0048484
GeneOntologyBiologicalProcesspost-translational protein targeting to endoplasmic reticulum membrane

SEC61A1 SEC61A2

1.67e-0421192GO:0006620
GeneOntologyBiologicalProcessSRP-dependent cotranslational protein targeting to membrane

SEC61A1 SEC61A2

2.78e-0427192GO:0006614
GeneOntologyBiologicalProcessintracellular protein transmembrane transport

SEC61A1 SEC61A2

3.68e-0431192GO:0065002
GeneOntologyBiologicalProcesscotranslational protein targeting to membrane

SEC61A1 SEC61A2

3.92e-0432192GO:0006613
GeneOntologyBiologicalProcessmale gonad development

LRP2 HOXA10 SOX8

4.92e-04171193GO:0008584
GeneOntologyBiologicalProcessdevelopment of primary male sexual characteristics

LRP2 HOXA10 SOX8

5.00e-04172193GO:0046546
GeneOntologyBiologicalProcesstRNA aminoacylation for protein translation

TARS1 TARS3

6.77e-0442192GO:0006418
GeneOntologyBiologicalProcessmale sex differentiation

LRP2 HOXA10 SOX8

7.65e-04199193GO:0046661
GeneOntologyBiologicalProcesstRNA aminoacylation

TARS1 TARS3

7.77e-0445192GO:0043039
GeneOntologyBiologicalProcessamino acid activation

TARS1 TARS3

8.12e-0446192GO:0043038
GeneOntologyBiologicalProcesstRNA metabolic process

TARS1 TARS3 MTO1

8.82e-04209193GO:0006399
GeneOntologyBiologicalProcessbrain morphogenesis

FANCC SLC6A4

9.21e-0449192GO:0048854
GeneOntologyBiologicalProcessautonomic nervous system development

SLC6A4 SOX8

9.59e-0450192GO:0048483
GeneOntologyBiologicalProcessprotein targeting to ER

SEC61A1 SEC61A2

1.04e-0352192GO:0045047
GeneOntologyBiologicalProcessestablishment of protein localization to endoplasmic reticulum

SEC61A1 SEC61A2

1.20e-0356192GO:0072599
GeneOntologyCellularComponentSec61 translocon complex

SEC61A1 SEC61A2

8.68e-065202GO:0005784
GeneOntologyCellularComponenttranslocon complex

SEC61A1 SEC61A2

1.30e-056202GO:0071256
GeneOntologyCellularComponentrough endoplasmic reticulum membrane

SEC61A1 SEC61A2

3.48e-0429202GO:0030867
GeneOntologyCellularComponentrough endoplasmic reticulum

SEC61A1 SEC61A2

1.69e-0364202GO:0005791
MousePhenounilateral cryptorchism

LRP2 HOXA10

2.08e-056172MP:0031286
MousePhenoabnormal male reproductive gland morphology

EIF4G3 FANCC KMT2E LRP2 HOXA10 FCGBP SOX8 AGPAT5

5.85e-051290178MP:0013325
MousePhenoabnormal internal male genitalia morphology

EIF4G3 FANCC KMT2E LRP2 HOXA10 FCGBP SOX8 AGPAT5

1.01e-041392178MP:0009205
MousePhenoabnormal male genitalia morphology

EIF4G3 FANCC KMT2E LRP2 HOXA10 FCGBP SOX8 AGPAT5

1.14e-041415178MP:0009198
MousePhenoabnormal male reproductive system morphology

EIF4G3 FANCC KMT2E LRP2 HOXA10 FCGBP SOX8 AGPAT5

1.14e-041415178MP:0001145
DomainPlug_translocon

SEC61A1 SEC61A2

1.09e-062202PF10559
DomainSecY_su_dom

SEC61A1 SEC61A2

1.09e-062202IPR023201
DomainSecY_CS

SEC61A1 SEC61A2

1.09e-062202IPR030659
DomainSecY

SEC61A1 SEC61A2

1.09e-062202PF00344
DomainSECY_1

SEC61A1 SEC61A2

1.09e-062202PS00755
DomainSECY_2

SEC61A1 SEC61A2

1.09e-062202PS00756
DomainSecY/SEC61-alpha

SEC61A1 SEC61A2

1.09e-062202IPR002208
Domain-

SEC61A1 SEC61A2

1.09e-0622021.10.3370.10
DomainTranslocon_Sec61/SecY_plug_dom

SEC61A1 SEC61A2

1.09e-062202IPR019561
DomainThrRS_core

TARS1 TARS3

3.27e-063202IPR033728
DomainThr-tRNA-ligase_IIa

TARS1 TARS3

3.27e-063202IPR002320
DomainTGS

TARS1 TARS3

1.63e-056202IPR004095
DomainTGS

TARS1 TARS3

1.63e-056202PF02824
DomainTGS-like

TARS1 TARS3

2.28e-057202IPR012676
DomaintRNA_SAD

TARS1 TARS3

2.28e-057202SM00863
DomaintRNA_SAD

TARS1 TARS3

2.28e-057202IPR012947
DomaintRNA_SAD

TARS1 TARS3

2.28e-057202PF07973
DomainThr/Ala-tRNA-synth_IIc_edit

TARS1 TARS3

3.04e-058202IPR018163
DomainHGTP_anticodon

TARS1 TARS3

3.90e-059202PF03129
Domainaa-tRNA-synt_IIb

TARS1 TARS3

5.96e-0511202IPR002314
DomaintRNA-synt_2b

TARS1 TARS3

5.96e-0511202PF00587
Domain-

TARS1 TARS3

5.96e-05112023.40.50.800
DomainAnticodon-bd

TARS1 TARS3

9.84e-0514202IPR004154
DomainBeta-grasp_dom

TARS1 TARS3

9.84e-0514202IPR012675
DomainTIL_dom

LRP2 FCGBP

9.84e-0514202IPR002919
Domain-

TARS1 TARS3

9.84e-05142023.10.20.30
Domainaa-tRNA-synth_II

TARS1 TARS3

1.65e-0418202IPR006195
DomainAA_TRNA_LIGASE_II

TARS1 TARS3

1.65e-0418202PS50862
DomainGrowth_fac_rcpt_

CELSR2 LRP2 RSPO4

5.87e-04156203IPR009030
DomainEGF

CELSR2 LRP2 FCGBP

1.91e-03235203SM00181
DomainEGF-like_dom

CELSR2 LRP2 FCGBP

2.26e-03249203IPR000742
DomainASX_HYDROXYL

CELSR2 LRP2

5.06e-03100202PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

CELSR2 LRP2

5.67e-03106202IPR000152
DomainEGF_CA

CELSR2 LRP2

7.45e-03122202SM00179
DomainEGF-like_Ca-bd_dom

CELSR2 LRP2

7.68e-03124202IPR001881
DomainEGF

CELSR2 LRP2

7.92e-03126202PF00008
Pubmed

Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.

SEC61A1 SEC61A2

3.14e-07220218480044
Pubmed

Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.

TARS1 TARS3

3.14e-07220237059185
Pubmed

A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.

TARS1 TARS3

3.14e-07220229579307
Pubmed

The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.

SEC61A1 SEC61A2

1.88e-06420210212142
Pubmed

Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.

SEC61A1 SEC61A2

3.14e-0652029565615
Pubmed

Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress.

SEC61A1 SEC61A2

4.71e-06620216705175
Pubmed

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

KMT2E HOXA10

8.78e-06820218952892
Pubmed

The role of assembly in insulin's biosynthesis.

SEC61A1 SEC61A2

2.07e-05122029631292
Pubmed

WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.

CELSR2 LRP2

1.85e-043520230940800
Pubmed

Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.

SEC61A1 FCGBP

4.75e-045620220706999
CoexpressionGSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_DN

EIF4G3 CRIP3 TARS3 AGPAT5

1.42e-05199204M9236
ToppCellCOPD-Lymphoid-ILC_B|COPD / Disease state, Lineage and Cell class

KMT2E TARS3 AGPAT5

5.37e-051662037609671e453280c6e522e9f659c06aab8be81945
ToppCellCOPD-Lymphoid-ILC_B|World / Disease state, Lineage and Cell class

KMT2E TARS3 AGPAT5

5.66e-0516920301987c00e0e398eb734613a55e71b4a2b1f0bb21
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA10 HID1 FCGBP

7.41e-05185203fd1911b57927c03470f9387962ca9581e5643fb3
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA10 HID1 FCGBP

7.41e-05185203e29079ef09aee62c3e9756341db4e59ca9dbf7ac
ToppCellfacs-Large_Intestine-Distal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA10 HID1 FCGBP

7.41e-051852037a18d525de6f874924bfc61b9666b307da86421a
ToppCellfacs-Large_Intestine-Distal-24m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA10 HID1 FCGBP

7.41e-051852032ecc4b76b3645b65c226c2298bff307cc6479172
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A4 HOXA10 HID1

7.53e-05186203af038994a6c32261f426b0c40c39be4a9099fe43
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 TBC1D10C SOX8

7.65e-051872035fae538de481367cf6d9a2d52190d77b99f6922c
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 TBC1D10C SOX8

7.65e-0518720322fd1959879705a8c1128faa9de66696c4e0b7e3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 TBC1D10C SOX8

7.65e-051872030526c0a818cf28fd5b6ff65fe260e3c3a4a98a2a
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A4 HOXA10 HID1

7.77e-051882035b69de5baaac45a6d4daa1dbfcb70a7b2ae744ac
ToppCelldroplet-Large_Intestine-COLON:P+D-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A4 HOXA10 HID1

7.89e-051892036f1696871a2994fd5f50b7cf4aa00e6d8054b603
ToppCellfacs-Large_Intestine-Distal|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA10 HID1 FCGBP

8.02e-051902033964a8390522b61b73235151bb0a2ff36b856867
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A4 HOXA10 HID1

8.02e-05190203a124e1c12af70161b9ead5d677afa660610444ee
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A4 HOXA10 HID1

8.14e-051912037411b253b16e4d472be0925dee49188f0fd6b0b5
ToppCellproximal-Epithelial-Serous|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HID1 FCGBP SOX8

8.66e-05195203cb62f04f0e45bfb36eed2e7a3fc54d6d390b2ed1
ToppCellproximal-Epithelial-Serous-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HID1 FCGBP SOX8

8.66e-0519520306b73abc1f32543f2a51db52dc6424a2a398fe0f
ToppCellproximal-3-Epithelial-Serous|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HID1 FCGBP SOX8

8.66e-0519520324a6a566143b04e37ad002e4c55037a0460ac2ef
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

CELSR2 KMT2E FCGBP

8.79e-0519620338da0751941adca650fe9b383d9f343153978eb5
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

CELSR2 KMT2E FCGBP

8.79e-05196203721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 LRP2 SOX8

9.19e-051992036fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 LRP2 SOX8

9.19e-051992035d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 LRP2 SOX8

9.19e-051992031bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CELSR2 LRP2 SOX8

9.19e-051992039dd4b17fb8c70ab9e126b23b72600463f3db832d
DrugAC1L7I6E

TARS1 TARS3

1.10e-056202CID000310900
Druggaillardin

SEC61A1 SEC61A2

2.05e-058202CID000267247
Diseaseamino acid metabolic disorder (implicated_via_orthology)

TARS1 TARS3

2.36e-064192DOID:9252 (implicated_via_orthology)
Diseaselongevity, healthspan, parental longevity

CELSR2 SLC6A4

1.58e-0429192EFO_0004300, EFO_0007796, EFO_0009762
Diseaseautistic disorder (is_implicated_in)

KMT2E SLC6A4

3.33e-0442192DOID:12849 (is_implicated_in)
DiseaseAntithrombotic agent use measurement

FANCC CELSR2

5.72e-0455192EFO_0009925
Diseaseleukemia

FANCC KMT2E

5.72e-0455192C0023418
Diseasesleep duration, low density lipoprotein cholesterol measurement

CELSR2 SLC6A4

1.55e-0391192EFO_0004611, EFO_0005271
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

CELSR2 AGPAT5

1.84e-0399192EFO_0004611, EFO_0007878
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

CELSR2 AGPAT5

1.95e-03102192EFO_0004329, EFO_0004611

Protein segments in the cluster

PeptideGeneStartEntry
HGYTCECPPNYLGPY

CELSR2

1851

Q9HCU4
HNLPLPGYGVQYDYL

MTO1

396

Q9Y2Z2
YIGLPYADHNYGARP

KMT2E

56

Q8IZD2
YGGACFCPPGYIINH

LRP2

326

P98164
GYYAHGGVYLPPAAD

HOXA10

56

P31260
HDGRYYPLGEVFYPG

FCGBP

4796

Q9Y6R7
QGLGYAPIDYYPGLL

FANCC

136

Q00597
YCHVPCYGYLFGPKG

CRIP3

171

Q6Q6R5
CGYYLHPLPAGAEYC

SCNN1D

571

P51172
YCIPQYRHSGPPYVG

EIF4G3

66

O43432
LYYGGHLCYGPPIEN

TARS3

246

A2RTX5
HLCYGPPIENGFYYD

TARS3

251

A2RTX5
GCLCYGPPIENGFYY

TARS1

171

P26639
YGKCLHDCPPGYFGI

RSPO4

66

Q2I0M5
GPARSYPVGGLCYYL

SEC61A2

331

Q9H9S3
VCAYDPVGYGIPYNH

HID1

256

Q8IV36
PGYAPGLYQYPCFHS

SOX8

396

P57073
GPARAYPVGGLCYYL

SEC61A1

331

P61619
VQICEVYLPGYYGPH

TBC1D10C

201

Q8IV04
LPLYGCYFAQHGGIY

AGPAT5

126

Q9NUQ2
PYICYQNGGGAFLLP

SLC6A4

106

P31645