Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

2.41e-0923164GO:0015377
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

4.07e-0926164GO:0015296
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A4 SLC12A7 SLC12A9

3.54e-089163GO:0015379
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 HCN1

1.56e-07167165GO:0015079
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 SLC6A11 HCN1

1.01e-06465166GO:0046873
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

2.06e-06119164GO:0015294
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

2.51e-06125164GO:0015108
GeneOntologyMolecularFunctionsymporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

5.19e-06150164GO:0015293
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

5.33e-06151164GO:0008509
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 SLC6A11 HCN1

5.73e-06627166GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 SLC6A11 HCN1

7.96e-06664166GO:0008324
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

8.72e-06171164GO:0015103
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 SLC6A11 HCN1

1.69e-05758166GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 SLC6A11 HCN1

2.19e-05793166GO:0015075
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

HCN4 HCN1

2.70e-0510162GO:0005222
GeneOntologyMolecularFunctionammonium channel activity

SLC12A4 SLC12A7

3.95e-0512162GO:0008519
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR1N2 MRGPRD OR1I1 VN1R4 F2RL3 OR2T33

4.04e-05884166GO:0004930
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN4 HCN1

4.67e-0513162GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN4 HCN1

4.67e-0513162GO:0043855
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

7.48e-05296164GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

7.98e-05301164GO:0022853
GeneOntologyMolecularFunctioncAMP binding

HCN4 HCN1

1.79e-0425162GO:0030552
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN4 HCN1

1.93e-0426162GO:0005248
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 SLC6A11 HCN1

2.01e-041180166GO:0022857
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

HCN4 HCN1

3.13e-0433162GO:0005217
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

HCN4 SLC6A11 HCN1

3.18e-04171163GO:0015081
GeneOntologyMolecularFunctiontransporter activity

SLC12A4 SLC12A7 SLC12A9 HCN4 SLC6A11 HCN1

3.26e-041289166GO:0005215
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR1N2 MRGPRD OR1I1 VN1R4 F2RL3 OR2T33

4.24e-041353166GO:0004888
GeneOntologyMolecularFunctioncyclic nucleotide binding

HCN4 HCN1

4.38e-0439162GO:0030551
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC12A4 SLC12A7 SLC12A9 SLC6A11

4.66e-04477164GO:0022804
GeneOntologyMolecularFunctionchannel activity

SLC12A4 SLC12A7 HCN4 HCN1

6.68e-04525164GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC12A4 SLC12A7 HCN4 HCN1

6.73e-04526164GO:0022803
GeneOntologyMolecularFunctionsodium channel activity

HCN4 HCN1

7.80e-0452162GO:0005272
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN4 HCN1

2.96e-03102162GO:0005249
GeneOntologyMolecularFunctionolfactory receptor activity

OR1N2 OR1I1 OR2T33

4.54e-03431163GO:0004984
GeneOntologyMolecularFunctionpotassium channel activity

HCN4 HCN1

4.61e-03128162GO:0005267
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

HCN4 HCN1

5.49e-03140162GO:0099094
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

HCN4 HCN1

6.44e-03152162GO:0022843
GeneOntologyMolecularFunctioncarboxylic ester hydrolase activity

PTRH2 LIPN

6.86e-03157162GO:0052689
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

HCN4 HCN1

9.12e-03182162GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

HCN4 HCN1

9.31e-03184162GO:0022832
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

HCN4 HCN1

1.02e-02193162GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

HCN4 HCN1

1.06e-02197162GO:0022834
GeneOntologyMolecularFunctiongated channel activity

HCN4 HCN1

2.87e-02334162GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

HCN4 HCN1

3.01e-02343162GO:0005261
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

SLC12A4 SLC12A7 SLC12A9 HCN4 HCN1

9.56e-07232175GO:0071805
GeneOntologyBiologicalProcesschloride ion homeostasis

SLC12A4 SLC12A7 SLC12A9

1.06e-0625173GO:0055064
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

SLC12A4 SLC12A7 SLC12A9

1.50e-0628173GO:0055081
GeneOntologyBiologicalProcesspotassium ion transport

SLC12A4 SLC12A7 SLC12A9 HCN4 HCN1

2.09e-06272175GO:0006813
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A4 SLC12A7 SLC12A9

3.55e-0637173GO:0055075
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A4 SLC12A7

3.83e-064172GO:0140157
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC12A4 SLC12A7 SLC12A9 HCN4 F2RL3 SLC6A11 HCN1

4.57e-06922177GO:0098662
GeneOntologyBiologicalProcesscell volume homeostasis

SLC12A4 SLC12A7 SLC12A9

5.23e-0642173GO:0006884
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC12A4 SLC12A7 SLC12A9 HCN4 F2RL3 SLC6A11 HCN1

5.27e-06942177GO:0098655
GeneOntologyBiologicalProcessmetal ion transport

SLC12A4 SLC12A7 SLC12A9 HCN4 F2RL3 SLC6A11 HCN1

7.81e-061000177GO:0030001
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC12A4 SLC12A7 SLC12A9 HCN4 F2RL3 SLC6A11 HCN1

8.73e-061017177GO:0098660
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

SLC12A4 SLC12A7 HCN4

9.45e-0651173GO:1990573
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC12A4 SLC12A7 SLC12A9 HCN4 F2RL3 SLC6A11 HCN1

1.59e-051115177GO:0034220
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC12A4 SLC12A7 SLC12A9 HCN4 F2RL3 SLC6A11 HCN1

2.03e-051157177GO:0006812
GeneOntologyBiologicalProcessammonium transmembrane transport

SLC12A4 SLC12A7

4.96e-0513172GO:0072488
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC12A4 SLC12A7 SLC12A9 HCN4 F2RL3 SLC6A11 HCN1

6.16e-051374177GO:0006811
GeneOntologyBiologicalProcesschloride transmembrane transport

SLC12A4 SLC12A7 SLC12A9

1.00e-04112173GO:1902476
GeneOntologyBiologicalProcesschloride transport

SLC12A4 SLC12A7 SLC12A9

1.49e-04128173GO:0006821
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC12A4 SLC12A7 SLC12A9

1.71e-04134173GO:0098661
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

SLC12A4 SLC12A7 HCN4

2.02e-04142173GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

SLC12A4 SLC12A7 HCN4

2.02e-04142173GO:0098659
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC12A4 SLC12A7 SLC12A9

2.52e-04153173GO:0098656
GeneOntologyBiologicalProcessinorganic anion transport

SLC12A4 SLC12A7 SLC12A9

4.06e-04180173GO:0015698
GeneOntologyBiologicalProcessmonoatomic anion transport

SLC12A4 SLC12A7 SLC12A9

4.26e-04183173GO:0006820
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR1N2 MRGPRD OR1I1 VN1R4 F2RL3 OR2T33

6.12e-041395176GO:0007186
GeneOntologyBiologicalProcesssodium ion transmembrane transport

HCN4 SLC6A11 HCN1

6.19e-04208173GO:0035725
GeneOntologyBiologicalProcessregulation of cell size

SLC12A4 SLC12A7 SLC12A9

7.78e-04225173GO:0008361
GeneOntologyBiologicalProcessimport across plasma membrane

SLC12A4 SLC12A7 HCN4

8.29e-04230173GO:0098739
GeneOntologyBiologicalProcesscellular response to cAMP

HCN4 HCN1

8.60e-0453172GO:0071320
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR1N2 OR1I1 VN1R4 OR2T33

8.84e-04547174GO:0007606
GeneOntologyBiologicalProcessregulation of membrane depolarization

HCN4 HCN1

1.14e-0361172GO:0003254
GeneOntologyBiologicalProcesssodium ion transport

HCN4 SLC6A11 HCN1

1.39e-03275173GO:0006814
GeneOntologyBiologicalProcessinorganic ion homeostasis

SLC12A4 SLC12A7 SLC12A9 F2RL3

1.43e-03622174GO:0098771
GeneOntologyBiologicalProcessregulation of action potential

HCN4 HCN1

1.99e-0381172GO:0098900
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

SLC12A4 SLC12A7 SLC12A9 F2RL3

2.26e-03705174GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

SLC12A4 SLC12A7 SLC12A9 F2RL3

2.40e-03717174GO:0050801
GeneOntologyBiologicalProcessresponse to cAMP

HCN4 HCN1

2.84e-0397172GO:0051591
GeneOntologyBiologicalProcessmembrane depolarization

HCN4 HCN1

4.38e-03121172GO:0051899
GeneOntologyBiologicalProcessregulation of cellular component size

SLC12A4 SLC12A7 SLC12A9

4.80e-03426173GO:0032535
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR1N2 OR1I1 OR2T33

4.99e-03432173GO:0050911
GeneOntologyBiologicalProcessresponse to organophosphorus

HCN4 HCN1

5.98e-03142172GO:0046683
GeneOntologyBiologicalProcesssensory perception of smell

OR1N2 OR1I1 OR2T33

6.12e-03465173GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR1N2 OR1I1 OR2T33

6.87e-03485173GO:0050907
GeneOntologyBiologicalProcesscellular homeostasis

SLC12A4 SLC12A7 SLC12A9 F2RL3

7.36e-03981174GO:0019725
GeneOntologyBiologicalProcessresponse to purine-containing compound

HCN4 HCN1

8.09e-03166172GO:0014074
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR1N2 OR1I1 OR2T33

8.50e-03524173GO:0009593
GeneOntologyBiologicalProcesssensory perception

OR1N2 OR1I1 VN1R4 OR2T33

1.00e-021072174GO:0007600
GeneOntologyBiologicalProcessimport into cell

SLC12A4 SLC12A7 HCN4 SLC6A11

1.01e-021074174GO:0098657
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR1N2 OR1I1 OR2T33

1.13e-02582173GO:0050906
GeneOntologyBiologicalProcessaction potential

HCN4 HCN1

1.17e-02201172GO:0001508
GeneOntologyBiologicalProcessregulation of anatomical structure size

SLC12A4 SLC12A7 SLC12A9

1.33e-02618173GO:0090066
GeneOntologyCellularComponentHCN channel complex

HCN4 HCN1

3.73e-064172GO:0098855
GeneOntologyCellularComponentvoltage-gated potassium channel complex

HCN4 HCN1

2.44e-0391172GO:0008076
GeneOntologyCellularComponentpotassium channel complex

HCN4 HCN1

3.18e-03104172GO:0034705
GeneOntologyCellularComponentplasma membrane protein complex

HCN4 TRBV11-1 TRBV7-9 HCN1

3.18e-03785174GO:0098797
MousePhenosinoatrial block

HCN4 HCN1

7.00e-0518102MP:0010520
MousePhenodecreased cardiac output

MRGPRD HCN1

3.03e-0437102MP:0003393
MousePhenoabnormal sinoatrial node conduction

HCN4 HCN1

3.91e-0442102MP:0006142
MousePhenoabnormal cardiac output

MRGPRD HCN1

6.95e-0456102MP:0001627
DomainSLC12_C

SLC12A4 SLC12A7 SLC12A9

2.34e-088153IPR018491
DomainSLC12

SLC12A4 SLC12A7 SLC12A9

2.34e-088153PF03522
DomainAA-permease/SLC12A_dom

SLC12A4 SLC12A7 SLC12A9

6.40e-0722153IPR004841
DomainAA_permease

SLC12A4 SLC12A7 SLC12A9

6.40e-0722153PF00324
DomainIon_trans_N

HCN4 HCN1

3.61e-064152PF08412
DomainKCL_cotranspt

SLC12A4 SLC12A7

3.61e-064152IPR000076
DomainIon_trans_N

HCN4 HCN1

3.61e-064152IPR013621
DomainGPCR_Rhodpsn_7TM

OR1N2 MRGPRD OR1I1 VN1R4 F2RL3 OR2T33

7.91e-06670156IPR017452
DomainG_PROTEIN_RECEP_F1_1

OR1N2 MRGPRD OR1I1 VN1R4 F2RL3 OR2T33

8.98e-06685156PS00237
DomainG_PROTEIN_RECEP_F1_2

OR1N2 MRGPRD OR1I1 VN1R4 F2RL3 OR2T33

9.44e-06691156PS50262
DomainGPCR_Rhodpsn

OR1N2 MRGPRD OR1I1 VN1R4 F2RL3 OR2T33

9.51e-06692156IPR000276
DomainSLC12A_fam

SLC12A4 SLC12A7

1.26e-057152IPR004842
DomainK_chnl_volt-dep_EAG/ELK/ERG

HCN4 HCN1

5.45e-0514152IPR003938
DomaincNMP-bd_CS

HCN4 HCN1

7.18e-0516152IPR018488
Domain7tm_1

OR1N2 MRGPRD OR1I1 F2RL3 OR2T33

1.37e-04677155PF00001
DomainCNMP_BINDING_1

HCN4 HCN1

2.94e-0432152PS00888
DomainCNMP_BINDING_2

HCN4 HCN1

2.94e-0432152PS00889
DomaincNMP

HCN4 HCN1

3.33e-0434152SM00100
DomaincNMP_binding

HCN4 HCN1

3.33e-0434152PF00027
DomainCNMP_BINDING_3

HCN4 HCN1

3.53e-0435152PS50042
DomaincNMP-bd_dom

HCN4 HCN1

3.53e-0435152IPR000595
DomaincNMP-bd-like

HCN4 HCN1

4.16e-0438152IPR018490
Domain-

HCN4 HCN1

6.65e-04481522.60.120.10
DomainRmlC-like_jellyroll

HCN4 HCN1

7.50e-0451152IPR014710
DomainOlfact_rcpt

OR1N2 OR1I1 OR2T33

3.49e-03393153IPR000725
DomainIon_trans_dom

HCN4 HCN1

3.68e-03114152IPR005821
DomainIon_trans

HCN4 HCN1

3.68e-03114152PF00520
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A4 SLC12A7

1.92e-057142M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A4 SLC12A7

1.92e-057142MM15081
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC12A4 SLC12A7 SLC6A11

1.51e-03238143MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC12A4 SLC12A7 SLC6A11

1.72e-03249143M5988
Pubmed

Cation-chloride cotransporters and neuronal function.

SLC12A4 SLC12A7 SLC12A9

8.13e-09917319323993
Pubmed

Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.

HCN4 HCN1

2.25e-07217217548059
Pubmed

Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.

HCN4 HCN1

2.25e-07217221456027
Pubmed

Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.

HCN4 HCN1

2.25e-07217211675786
Pubmed

Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

HCN4 HCN1

2.25e-07217219135060
Pubmed

EP3 activation facilitates bladder excitability via HCN channels on ICCs.

HCN4 HCN1

6.74e-07317228131828
Pubmed

Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.

HCN4 HCN1

6.74e-07317221187420
Pubmed

Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

HCN4 HCN1

6.74e-07317222006928
Pubmed

Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.

HCN4 HCN1

6.74e-07317222652004
Pubmed

HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.

HCN4 HCN1

6.74e-07317233181864
Pubmed

Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.

HCN4 HCN1

6.74e-07317221945247
Pubmed

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

SLC12A4 SLC12A7

6.74e-07317211551954
Pubmed

K-Cl cotransporter gene expression during human and murine erythroid differentiation.

SLC12A4 SLC12A7

6.74e-07317221733850
Pubmed

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.

SLC12A4 SLC12A7

6.74e-07317215262997
Pubmed

Functional expression of the human HCN3 channel.

HCN4 HCN1

1.35e-06417216043489
Pubmed

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

SLC12A4 SLC12A7

1.35e-06417212637262
Pubmed

Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.

HCN4 HCN1

1.35e-06417220140458
Pubmed

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

HCN4 HCN1

1.35e-06417222748890
Pubmed

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

HCN4 HCN1

1.35e-0641729630217
Pubmed

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

HCN4 HCN1

1.35e-0641729405696
Pubmed

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.

HCN4 HCN1

1.35e-06417212928435
Pubmed

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

HCN4 HCN1

1.35e-06417221615589
Pubmed

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.

HCN4 HCN1

2.25e-06517234429357
Pubmed

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.

HCN4 HCN1

2.25e-06517215564593
Pubmed

Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.

HCN4 HCN1

3.37e-06617225761792
Pubmed

Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.

HCN4 HCN1

4.72e-06717219421833
Pubmed

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

SLC12A4 SLC12A7

6.29e-06817211395011
Pubmed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

SLC12A4 SLC12A7

6.29e-06817224393035
Pubmed

Similar effects of all WNK3 variants on SLC12 cotransporters.

SLC12A4 SLC12A7

6.29e-06817221613606
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

SLC12A4 SLC12A7

6.29e-06817212386165
Pubmed

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.

HCN4 HCN1

1.01e-051017216382102
Pubmed

Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

HCN4 WNT8A

1.48e-051217222544366
Pubmed

Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.

HCN4 HCN1

1.48e-051217217482496
Pubmed

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

HCN4 HCN1

2.04e-051417229107716
Pubmed

Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.

HCN4 HCN1

2.35e-051517221147989
Pubmed

Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.

HCN4 HCN1

3.42e-051817227180262
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

HCN4 HCN1

4.70e-052117230270038
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

SLC12A4 SLC12A7

5.16e-052217218391953
Pubmed

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.

HCN4 HCN1

1.04e-043117217473172
Pubmed

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.

HCN4 WNT8A

1.04e-043117225053429
Pubmed

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

HCN4 HCN1

2.30e-044617237207277
Pubmed

Identification of G protein-coupled receptor genes from the human genome sequence.

MRGPRD VN1R4

2.30e-044617212044878
Pubmed

Protein Binder Toolbox for Studies of Solute Carrier Transporters.

SLC12A4 SLC12A7

3.41e-045617238878854
InteractionOR10H2 interactions

SLC12A4 SLC12A7 PTRH2 SLC12A9

4.85e-0872114int:OR10H2
InteractionGPR21 interactions

SLC12A4 SLC12A7 PTRH2 SLC12A9

7.82e-0881114int:GPR21
InteractionOR4N2 interactions

SLC12A4 SLC12A7 SLC12A9

4.39e-0729113int:OR4N2
InteractionMS4A15 interactions

SLC12A4 SLC12A7 SLC12A9

1.09e-0639113int:MS4A15
InteractionOR10H1 interactions

SLC12A4 SLC12A7 PTRH2

2.20e-0649113int:OR10H1
InteractionCLRN2 interactions

SLC12A4 SLC12A7 SLC12A9

8.32e-0676113int:CLRN2
InteractionHCN4 interactions

HCN4 HCN1

9.73e-069112int:HCN4
InteractionPTH1R interactions

SLC12A4 SLC12A7 SLC12A9

1.29e-0588113int:PTH1R
InteractionRXFP1 interactions

SLC12A4 SLC12A7 SLC12A9

1.38e-0590113int:RXFP1
InteractionHCN3 interactions

HCN4 HCN1

1.49e-0511112int:HCN3
InteractionHCN2 interactions

HCN4 HCN1

2.11e-0513112int:HCN2
InteractionLGALS3 interactions

SLC12A4 SLC12A7 SLC12A9 HCN1

2.39e-05340114int:LGALS3
InteractionZDHHC12 interactions

SLC12A4 SLC12A7 SLC12A9

3.53e-05123113int:ZDHHC12
InteractionSLC12A5 interactions

SLC12A4 SLC12A7

5.66e-0521112int:SLC12A5
InteractionPOPDC2 interactions

SLC12A7 SLC12A9

6.81e-0523112int:POPDC2
InteractionOR1D4 interactions

SLC12A7 SLC12A9

8.74e-0526112int:OR1D4
InteractionLGALS8 interactions

SLC12A4 SLC12A7 SLC12A9

9.92e-05174113int:LGALS8
InteractionTMC4 interactions

SLC12A4 SLC12A7

1.17e-0430112int:TMC4
InteractionNMUR2 interactions

SLC12A7 SLC12A9

1.25e-0431112int:NMUR2
InteractionLGALS9C interactions

SLC12A4 SLC12A7

1.60e-0435112int:LGALS9C
InteractionLGALS9 interactions

SLC12A4 SLC12A7 PTRH2 SLC12A9

2.01e-04588114int:LGALS9
InteractionNRN1 interactions

SLC12A4 SLC12A7

2.09e-0440112int:NRN1
InteractionLGALS9B interactions

SLC12A4 SLC12A7

2.65e-0445112int:LGALS9B
InteractionDPM2 interactions

SLC12A4 SLC12A7

3.82e-0454112int:DPM2
InteractionPEX5L interactions

HCN4 HCN1

3.82e-0454112int:PEX5L
InteractionSERINC2 interactions

SLC12A7 PTRH2

3.96e-0455112int:SERINC2
InteractionSLC17A2 interactions

SLC12A4 SLC12A7

4.10e-0456112int:SLC17A2
InteractionTTYH1 interactions

SLC12A4 SLC12A7 SLC12A9

4.93e-04300113int:TTYH1
InteractionCD55 interactions

SLC12A4 PTRH2

5.03e-0462112int:CD55
InteractionC3orf52 interactions

SLC12A4 SLC12A7 SLC12A9

5.18e-04305113int:C3orf52
InteractionNKAIN1 interactions

SLC12A4 SLC12A9

5.53e-0465112int:NKAIN1
InteractionCHRND interactions

SLC12A4 SLC12A9

6.41e-0470112int:CHRND
InteractionCX3CL1 interactions

SLC12A4 SLC12A9

6.59e-0471112int:CX3CL1
InteractionC5AR2 interactions

SLC12A7 SLC12A9

7.95e-0478112int:C5AR2
InteractionPTGIR interactions

SLC12A7 SLC12A9

7.95e-0478112int:PTGIR
InteractionENTREP1 interactions

SLC12A4 SLC12A9

9.66e-0486112int:ENTREP1
InteractionRND2 interactions

SLC12A4 SLC12A7 PTRH2

1.50e-03440113int:RND2
InteractionHCN1 interactions

HCN4 HCN1

1.52e-03108112int:HCN1
InteractionMARCHF4 interactions

SLC12A4 SLC12A7

1.63e-03112112int:MARCHF4
InteractionFLOT1 interactions

SLC12A4 SLC12A7 PTRH2

1.86e-03475113int:FLOT1
InteractionPDE2A interactions

SLC12A4 PTRH2

1.87e-03120112int:PDE2A
InteractionSLC12A6 interactions

SLC12A4 SLC12A7

1.99e-03124112int:SLC12A6
InteractionTMEM74 interactions

SLC12A9 HCN1

2.02e-03125112int:TMEM74
InteractionSLC12A4 interactions

SLC12A4 SLC12A7

2.15e-03129112int:SLC12A4
InteractionSLC12A7 interactions

SLC12A4 SLC12A7

2.25e-03132112int:SLC12A7
InteractionSIDT2 interactions

SLC12A7 SLC12A9

2.53e-03140112int:SIDT2
InteractionSLC18A1 interactions

PTRH2 SLC12A9

2.97e-03152112int:SLC18A1
InteractionCNTNAP2 interactions

HCN4 HCN1

3.21e-03158112int:CNTNAP2
InteractionPIGH interactions

SLC12A4 SLC12A7

3.33e-03161112int:PIGH
InteractionRHOC interactions

SLC12A4 SLC12A7 PTRH2

3.36e-03584113int:RHOC
InteractionRAC3 interactions

SLC12A4 SLC12A7 PTRH2

3.96e-03619113int:RAC3
InteractionRHOJ interactions

SLC12A4 SLC12A7 PTRH2

4.21e-03633113int:RHOJ
InteractionSLC31A1 interactions

SLC12A4 SLC12A7

4.69e-03192112int:SLC31A1
InteractionPEX5 interactions

PTRH2 HCN1

4.84e-03195112int:PEX5
InteractionNRAS interactions

SLC12A4 SLC12A7 PTRH2

5.57e-03699113int:NRAS
InteractionANKLE2 interactions

PTRH2 OR2T33

5.59e-03210112int:ANKLE2
InteractionRAB5A interactions

SLC12A4 SLC12A7 PTRH2

5.72e-03706113int:RAB5A
Cytoband7q34

TRBV11-1 TRBV7-9

1.73e-031671727q34
CytobandEnsembl 112 genes in cytogenetic band chr7q34

TRBV11-1 TRBV7-9

2.11e-03185172chr7q34
GeneFamilyCyclic nucleotide gated channels

HCN4 HCN1

3.29e-0510162250
GeneFamilySolute carriers

SLC12A4 SLC12A7 SLC12A9 SLC6A11

3.32e-04395164752
GeneFamilyOlfactory receptors, family 1

OR1N2 OR1I1

5.62e-0440162147
GeneFamilyT cell receptor beta locus at 7q34

TRBV11-1 TRBV7-9

2.63e-0387162372
Drug((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid

SLC12A4 SLC12A7

4.05e-072152ctd:C095651
DrugTrichlormethiazide

SLC12A4 SLC12A7

4.05e-065152ctd:D014237
DrugPotassium Chloride

SLC12A4 SLC12A7

6.07e-066152DB00761
Drugbumetanide

SLC12A4 SLC12A7 SLC12A9 SLC6A11

8.70e-06209154CID000002471
Drugmenthol

MRGPRD HCN4 HCN1

2.37e-0587153CID000001254
Drugfurosemide

SLC12A4 SLC12A7 SLC12A9 SLC6A11

2.45e-05272154CID000003440
Drug8-bromoguanosine 3',5'-cyclic monophosphate

SLC12A4 SLC12A7 HCN4 HCN1

3.99e-05308154CID000001915
DrugBumetanide

SLC12A4 SLC12A7

4.84e-0516152ctd:D002034
Drugzatebradine

HCN4 HCN1

5.48e-0517152CID000065637
DrugHCNs

HCN4 HCN1

7.64e-0520152CID006857665
Drug4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid

SLC12A4 SLC12A7

2.25e-0434152ctd:D017878
Drugivabradine

HCN4 HCN1

2.96e-0439152CID000132999
Drug1q1g

HCN4 HCN1

2.96e-0439152CID000447992
DrugZidovudine

SLC12A4 SLC12A9 SLC6A11 HCN1

3.03e-04521154ctd:D015215
Drugpyridine-2-aldoxime

SLC12A4 SLC6A11

3.11e-0440152CID005356792
DrugSn-D

SLC12A9 HCN4

5.07e-0451152CID003081386
Drug1-hydroxypyrene

SLC12A7 VN1R4

5.07e-0451152ctd:C033146
DrugCID5255110

HCN4 HCN1

6.33e-0457152CID005255110
Druggamma-Aminobutyric Acid

SLC6A11 HCN1

7.49e-0462152ctd:D005680
Drugbupranolol

HCN4 HCN1

7.73e-0463152CID000002475
Diseasesick sinus syndrome (implicated_via_orthology)

HCN4 HCN1

7.23e-073152DOID:13884 (implicated_via_orthology)
Diseasevisual epilepsy (biomarker_via_orthology)

SLC6A11 HCN1

9.41e-0490152DOID:11832 (biomarker_via_orthology)
DiseasePR interval

SLC12A7 HCN4 HCN1

1.84e-03495153EFO_0004462
DiseaseQT interval

SLC12A7 PTRH2 WNT8A

2.28e-03534153EFO_0004682
Diseaseresting heart rate

SLC12A9 HCN4

2.55e-03149152EFO_0004351
DiseaseParoxysmal atrial fibrillation

HCN4 WNT8A

2.79e-03156152C0235480
DiseasePersistent atrial fibrillation

HCN4 WNT8A

2.79e-03156152C2585653
Diseasefamilial atrial fibrillation

HCN4 WNT8A

2.79e-03156152C3468561
DiseaseAtrial Fibrillation

HCN4 WNT8A

2.93e-03160152C0004238
Diseaseepilepsy (implicated_via_orthology)

SLC12A4 SLC12A7

3.04e-03163152DOID:1826 (implicated_via_orthology)
Diseasediastolic blood pressure, systolic blood pressure

OR1I1 HCN4 HCN1

4.33e-03670153EFO_0006335, EFO_0006336
DiseaseJT interval

SLC12A7 PTRH2

6.87e-03248152EFO_0007885
DiseaseQRS duration

HCN1 WNT8A

9.79e-03298152EFO_0005055
Diseaseatrial fibrillation

HCN4 WNT8A

1.49e-02371152EFO_0000275

Protein segments in the cluster

PeptideGeneStartEntry
MMWLLLTTTCLICGT

LIPN

1

Q5VXI9
CGLLWTLCLLMNGLT

MRGPRD

146

Q8TDS7
MCSPVCGLLLGASWM

OR1I1

136

O60431
WQLCLRMTMSCWLLG

OR2T33

136

Q8NG76
LIGMMLLLCHWDGCL

HCN4

421

Q9Y3Q4
RLALGLCMAAWLMAA

F2RL3

191

Q96RI0
LIGMMLLLCHWDGCL

HCN1

301

O60741
WTLSFLGMSLCLALM

SLC12A7

616

Q9Y666
LGMSLCLALMFICSW

SLC12A7

621

Q9Y666
MLGVCWVLTNCPALM

OR1N2

161

Q8NGR9
WALSFLGMSLCLALM

SLC12A4

616

Q9UP95
GMCLGWSLRVCFGML

PTRH2

26

Q9Y3E5
WHTCLLGVASCLLMM

SLC12A9

456

Q9BXP2
LMALSSMLCIPLWIC

SLC6A11

556

P48066
CLGLMLWVSSSMVCI

VN1R4

191

Q7Z5H5
MSTRLLCWMALCLLG

TRBV11-1

1

A0A0K0K1C0
MGTSLLCWMALCLLG

TRBV7-9

1

P04435
MGNLFMLWAALGICC

WNT8A

1

Q9H1J5