Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

1.96e-085263GO:0030156
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 CHAT RIMBP3C RIMBP3B

8.10e-0836244GO:0007274
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

4.85e-0628253GO:0002177
GeneOntologyCellularComponentprecatalytic spliceosome

LSM4 PRPF38B SNRPD3

3.60e-0554253GO:0071011
GeneOntologyCellularComponentspliceosomal complex

LSM4 PRPF38B SNRPD3 HNRNPR

1.16e-04215254GO:0005681
GeneOntologyCellularComponentU4/U6 x U5 tri-snRNP complex

LSM4 SNRPD3

1.44e-0347252GO:0046540
GeneOntologyCellularComponentspliceosomal tri-snRNP complex

LSM4 SNRPD3

1.50e-0348252GO:0097526
GeneOntologyCellularComponentU2-type precatalytic spliceosome

LSM4 SNRPD3

1.69e-0351252GO:0071005
GeneOntologyCellularComponentribonucleoprotein complex

LSM4 PRPF38B FBLL1 SNRPD3 RRS1 HNRNPR

2.37e-031194256GO:1990904
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

2.03e-0619193MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

2.79e-0621193MP:0008893
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B

2.72e-0544193MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B

2.91e-0545193MP:0009376
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

5.64e-0556193MP:0009237
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3C RIMBP3B

1.30e-0474193MP:0009232
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B SH3RF2

2.81e-0678244PF14604
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B SH3RF2

4.15e-0686244IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B SH3RF2

4.15e-0686244PF07653
DomainLSm4/Sm_D1/D3

LSM4 SNRPD3

4.74e-063242IPR027141
DomainSH3

RIMBP3 RIMBP3C RIMBP3B SH3RF2

1.54e-04216244PS50002
DomainSH3

RIMBP3 RIMBP3C RIMBP3B SH3RF2

1.54e-04216244SM00326
DomainSH3_domain

RIMBP3 RIMBP3C RIMBP3B SH3RF2

1.65e-04220244IPR001452
DomainLSM

LSM4 SNRPD3

2.67e-0419242PF01423
DomainLSM_dom_euk/arc

LSM4 SNRPD3

2.67e-0419242IPR001163
DomainSm

LSM4 SNRPD3

2.67e-0419242SM00651
DomainLSM_dom

LSM4 SNRPD3

3.60e-0422242IPR010920
DomainFN3

RIMBP3 RIMBP3C RIMBP3B

2.04e-03199243PS50853
DomainRRM_1

RBM27 RALYL HNRNPR

2.32e-03208243PF00076
DomainFN3_dom

RIMBP3 RIMBP3C RIMBP3B

2.35e-03209243IPR003961
DomainRRM

RBM27 RALYL HNRNPR

2.61e-03217243SM00360
DomainRRM_dom

RBM27 RALYL HNRNPR

2.97e-03227243IPR000504
DomainRRM

RBM27 RALYL HNRNPR

3.08e-03230243PS50102
Domain-

RBM27 RALYL HNRNPR

3.64e-032442433.30.70.330
DomainNucleotide-bd_a/b_plait

RBM27 RALYL HNRNPR

4.25e-03258243IPR012677
DomainFN3

RIMBP3C RIMBP3B

2.33e-02185242SM00060
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

1.48e-09426319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

3.70e-09526317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

1.34e-071426317662146
Pubmed

82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions.

CHAT SATB1

5.37e-07226227052102
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

LSM4 PRPF38B FBLL1 RBM27 SNRPD3 RRS1 HNRNPR

8.18e-0773126729298432
Pubmed

Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons.

CHAT HNRNPR

5.37e-06526225338097
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

RTF1 FBLL1 RBM27 SNRPD3 RRS1 HNRNPR DNTTIP1

6.03e-0698926736424410
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

LSM4 PRPF38B RBM27 SNRPD3 RRS1 HNRNPR

1.18e-0571326629802200
Pubmed

Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).

LSM4 SNRPD3

2.94e-051126210851237
Pubmed

Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.

CHAT ITPR3

3.53e-051226232294408
Pubmed

Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium.

CHAT ITPR3

5.61e-051526224428937
Pubmed

SH3RF2 functions as an oncogene by mediating PAK4 protein stability.

SH3RF2 DNTTIP1

8.16e-051826224130170
Pubmed

Molecular architecture of the human U4/U6.U5 tri-snRNP.

LSM4 SNRPD3

9.12e-051926226912367
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PRPF38B FBLL1 RBM27 SNRPD3 RRS1 HNRNPR

1.21e-04108226638697112
Pubmed

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.

LSM4 SNRPD3 HNRNPR

1.79e-0414726328977470
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

RBM27 RRS1 HNRNPR

1.83e-0414826332538781
Pubmed

MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs.

CHAT SATB1

1.86e-042726233787491
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PRPF38B RBM27 DNTTIP1 ITPR3

2.03e-0439626426687479
Pubmed

Mechanism of 5' splice site transfer for human spliceosome activation.

LSM4 SNRPD3

2.15e-042926230975767
Pubmed

Identification of novel transcription-regulating genes expressed during murine molar development.

LSM4 HNRNPR

2.15e-042926222639370
Pubmed

Role of Elavl-like RNA-binding protein in retinal development and signal transduction.

CHAT SATB1

2.47e-043126239307290
Pubmed

Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

LSM4 SNRPD3

2.47e-043126228878014
Pubmed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

LSM4 SNRPD3

2.80e-043326228781166
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

LSM4 RBM27 SNRPD3 RRS1 HNRNPR

2.91e-0480726522681889
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

LSM4 RBM27 SNRPD3 HNRNPR DNTTIP1 ITPR3

3.18e-04129426630804502
Pubmed

Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.

SATB1 DNTTIP1

3.52e-043726212766061
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

LSM4 SNRPD3 HNRNPR

5.83e-0422026324550385
Pubmed

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

RIMBP3C SH3RF2

6.44e-045026219807924
InteractionZC3H18 interactions

RTF1 LSM4 PRPF38B FBLL1 RBM27 SNRPD3 RRS1 HNRNPR

6.96e-06877258int:ZC3H18
InteractionCIT interactions

LSM4 PRPF38B FBLL1 RBM27 SNRPD3 RRS1 RALYL HNRNPR ITPR3

3.58e-051450259int:CIT
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

3.43e-0511126322q11.21
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3C RIMBP3B SNRPD3

8.72e-05419264chr22q11
Cytoband5q32

RBM27 SH3RF2

4.33e-04542625q32
CytobandEnsembl 112 genes in cytogenetic band chr5q32

RBM27 SH3RF2

9.48e-0480262chr5q32
GeneFamilyRNA binding motif containing

RBM27 RALYL HNRNPR

1.82e-04213103725
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

SH3RF2 ITPR3

4.25e-03181102694
ComputationalNeighborhood of PTPN11

LSM4 SNRPD3 HNRNPR

2.03e-04108123MORF_PTPN11
ComputationalNeighborhood of TDG

SNRPD3 HNRNPR

6.66e-0435122GNF2_TDG
DiseaseAmyotrophic Lateral Sclerosis, Familial

SHC1 OTOG

6.41e-0448232C4551993
DiseaseAmyotrophic Lateral Sclerosis, Sporadic

SHC1 OTOG

6.41e-0448232C1862941
DiseaseAMYOTROPHIC LATERAL SCLEROSIS 1

SHC1 OTOG

6.96e-0450232C1862939
Diseasepeptide measurement

CHAT RBM27

3.25e-03109232EFO_0010520
Diseasesleep quality

OTOG RALYL

3.80e-03118232EFO_0005272
DiseaseVertigo

RTF1 OTOG

5.22e-03139232HP_0002321
Diseasevenous thromboembolism

LSM4 SATB1 ITPR3

5.29e-03460233EFO_0004286
Diseaseautism spectrum disorder (implicated_via_orthology)

SH3RF2 ITPR3

6.21e-03152232DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
TMGTERSRGGKRGPQ

nan

6

A8MZ25
SGTGAGIMGRKNRNL

CEP112

51

Q8N8E3
GKGLMTARGGNRRDT

C16orf78

71

Q8WTQ4
MRRSSGFGGQKGQGP

ANKRD26P1

1

Q6NSI1
TRRGKGVFSMKGGSR

RALYL

166

Q86SE5
VGRGKTMSSQGRGRG

RBM27

941

Q9P2N5
QMGGQGKGRLALRAG

RIMBP3B

1586

A6NNM3
QMGGQGKGRLALRAG

RIMBP3C

1586

A6NJZ7
KAAGMGAQGRTGRRN

ITPR3

331

Q14573
GGGQRRGGVAKSKSR

FBLL1

76

A6NHQ2
SRGNRGGNVGGKRKA

HNRNPR

561

O43390
LRLARKGSMRAGQGG

NIPA2

36

Q8N8Q9
MKQRKGQGSGGSRGR

C2CD3

1

Q4AC94
GQGSGGSRGRKKRGL

C2CD3

6

Q4AC94
LMAQEKGASRGRGGN

SLC1A6

546

P48664
QKQQKGRGMGGAGRG

LSM4

96

Q9Y4Z0
SGARGMRNVKGMRNG

OTOG

41

Q6ZRI0
GGRRGSRGTTMVKKR

RTF1

31

Q92541
QMGGQGKGRLALRAG

RIMBP3

1586

Q9UFD9
GRGRLGSTGAKMQGV

SATB1

41

Q01826
MGLRTAKKRGLGGGG

CHAT

1

P28329
GSRANKALGMGGTRG

DNTTIP1

216

Q9H147
MSQKGKRKGGRQGPG

RRS1

306

Q15050
KGSRKTAGQTGMCGG

PRPF38B

101

Q5VTL8
GRGRGMGRGNIFQKR

SNRPD3

111

P62318
QGSLRKGRSSMRKNG

SH3RF2

506

Q8TEC5
MAGKGRAGGRKCGQR

ZNF831

596

Q5JPB2
MNKLSGGGGRRTRVE

SHC1

111

P29353