Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine phosphatase activity	PTPRD PTPRF PTPRG PTPRT	2.90e-08	17	39	4	GO:0005001
GeneOntologyMolecularFunction	transmembrane receptor protein phosphatase activity	PTPRD PTPRF PTPRG PTPRT	2.90e-08	17	39	4	GO:0019198
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR1L6 GPRC5D GRIK5 PTPRD PTPRF PTPRG OR52B2 UNC5B PTPRT OR9Q1 OR5D13	3.80e-05	1353	39	11	GO:0004888
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	PTPRD PTPRF PTPRG PTPRT	4.78e-05	103	39	4	GO:0004725
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	1.03e-04	8	39	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D	1.66e-04	10	39	2	GO:0140999
GeneOntologyMolecularFunction	phosphoprotein phosphatase activity	PTPRD PTPRF PTPRG PTPRT	4.94e-04	189	39	4	GO:0004721
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D	6.91e-04	20	39	2	GO:0042800
GeneOntologyCellularComponent	postsynaptic density membrane	SHISA9 GRIK5 PTPRF PTPRT	2.05e-04	157	39	4	GO:0098839
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C KMT2D	2.21e-04	12	39	2	GO:0044666
GeneOntologyCellularComponent	stereocilium	PCDH15 SLC4A7 MYO15A	2.89e-04	69	39	3	GO:0032420
GeneOntologyCellularComponent	stereocilium bundle	PCDH15 SLC4A7 MYO15A	4.30e-04	79	39	3	GO:0032421
GeneOntologyCellularComponent	postsynaptic specialization membrane	SHISA9 GRIK5 PTPRF PTPRT	5.24e-04	201	39	4	GO:0099634
MousePheno	abnormal cochlear hair cell inter-stereocilial links morphology	PCDH15 MYO15A	1.28e-04	9	27	2	MP:0004577
MousePheno	organ of Corti degeneration	PCDH15 SLC4A7 MYO15A	1.41e-04	53	27	3	MP:0000043
MousePheno	cochlear ganglion hypoplasia	PCDH15 MYO15A	1.95e-04	11	27	2	MP:0003637
MousePheno	cochlear degeneration	PCDH15 SLC4A7 MYO15A	2.25e-04	62	27	3	MP:0000032
MousePheno	cochlear ganglion degeneration	PCDH15 SLC4A7 MYO15A	2.36e-04	63	27	3	MP:0002857
Domain	PTPc	PTPRD PTPRF PTPRG PTPRT	8.19e-07	36	38	4	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPRD PTPRF PTPRG PTPRT	1.14e-06	39	38	4	PS50055
Domain	PTPase_domain	PTPRD PTPRF PTPRG PTPRT	1.40e-06	41	38	4	IPR000242
Domain	Y_phosphatase	PTPRD PTPRF PTPRG PTPRT	1.40e-06	41	38	4	PF00102
Domain	PTPc_motif	PTPRD PTPRF PTPRG PTPRT	6.12e-06	59	38	4	SM00404
Domain	Tyr_Pase_cat	PTPRD PTPRF PTPRG PTPRT	6.12e-06	59	38	4	IPR003595
Domain	Tyr_Pase_AS	PTPRD PTPRF PTPRG PTPRT	1.43e-05	73	38	4	IPR016130
Domain	fn3	PTPRD PTPRF PTPRG PTPRT MYOM3	1.84e-05	162	38	5	PF00041
Domain	TYR_PHOSPHATASE_1	PTPRD PTPRF PTPRG PTPRT	2.74e-05	86	38	4	PS00383
Domain	TYR_PHOSPHATASE_2	PTPRD PTPRF PTPRG PTPRT	2.87e-05	87	38	4	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPRD PTPRF PTPRG PTPRT	2.87e-05	87	38	4	IPR000387
Domain	FN3	PTPRD PTPRF PTPRG PTPRT MYOM3	3.48e-05	185	38	5	SM00060
Domain	-	PTPRD PTPRF PTPRG PTPRT	3.58e-05	92	38	4	3.90.190.10
Domain	FYrich_C	KMT2C KMT2D	4.02e-05	5	38	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	4.02e-05	5	38	2	IPR003888
Domain	FYRC	KMT2C KMT2D	4.02e-05	5	38	2	SM00542
Domain	FYRN	KMT2C KMT2D	4.02e-05	5	38	2	SM00541
Domain	FYRN	KMT2C KMT2D	4.02e-05	5	38	2	PF05964
Domain	FYRC	KMT2C KMT2D	4.02e-05	5	38	2	PF05965
Domain	FYRC	KMT2C KMT2D	4.02e-05	5	38	2	PS51543
Domain	FYRN	KMT2C KMT2D	4.02e-05	5	38	2	PS51542
Domain	-	CD1B PTPRD PTPRF PTPRG UNC5B PTPRT ICAM2 MYOM3	4.60e-05	663	38	8	2.60.40.10
Domain	Prot-tyrosine_phosphatase-like	PTPRD PTPRF PTPRG PTPRT	4.77e-05	99	38	4	IPR029021
Domain	FN3	PTPRD PTPRF PTPRG PTPRT MYOM3	4.93e-05	199	38	5	PS50853
Domain	IG_LIKE	CD1B PTPRD PTPRF UNC5B PTPRT ICAM2 MYOM3	5.18e-05	491	38	7	PS50835
Domain	Ig-like_dom	CD1B PTPRD PTPRF UNC5B PTPRT ICAM2 MYOM3	6.03e-05	503	38	7	IPR007110
Domain	FN3_dom	PTPRD PTPRF PTPRG PTPRT MYOM3	6.22e-05	209	38	5	IPR003961
Domain	Ig-like_fold	CD1B PTPRD PTPRF PTPRG UNC5B PTPRT ICAM2 MYOM3	7.16e-05	706	38	8	IPR013783
Domain	Post-SET_dom	KMT2C KMT2D	4.75e-04	16	38	2	IPR003616
Domain	PostSET	KMT2C KMT2D	4.75e-04	16	38	2	SM00508
Domain	POST_SET	KMT2C KMT2D	4.75e-04	16	38	2	PS50868
Domain	Ig_I-set	PTPRD PTPRF UNC5B MYOM3	5.84e-04	190	38	4	IPR013098
Domain	I-set	PTPRD PTPRF UNC5B MYOM3	5.84e-04	190	38	4	PF07679
Domain	EPHD	KMT2C KMT2D	9.08e-04	22	38	2	PS51805
Domain	IGc2	PTPRD PTPRF UNC5B MYOM3	1.29e-03	235	38	4	SM00408
Domain	Ig_sub2	PTPRD PTPRF UNC5B MYOM3	1.29e-03	235	38	4	IPR003598
Domain	IG	PTPRD PTPRF UNC5B PTPRT MYOM3	1.55e-03	421	38	5	SM00409
Domain	Ig_sub	PTPRD PTPRF UNC5B PTPRT MYOM3	1.55e-03	421	38	5	IPR003599
Domain	SET	KMT2C KMT2D	3.14e-03	41	38	2	PF00856
Domain	SET	KMT2C KMT2D	3.94e-03	46	38	2	SM00317
Domain	SET_dom	KMT2C KMT2D	4.64e-03	50	38	2	IPR001214
Domain	SET	KMT2C KMT2D	4.64e-03	50	38	2	PS50280
Domain	HMG_box	KMT2C KMT2D	5.20e-03	53	38	2	PF00505
Domain	HMG	KMT2C KMT2D	5.40e-03	54	38	2	SM00398
Domain	HMG_box_dom	KMT2C KMT2D	7.73e-03	65	38	2	IPR009071
Domain	Olfact_rcpt	OR1L6 OR52B2 OR9Q1 OR5D13	8.10e-03	393	38	4	IPR000725
Domain	PHD	KMT2C KMT2D	1.02e-02	75	38	2	PF00628
Domain	Znf_PHD-finger	KMT2C KMT2D	1.13e-02	79	38	2	IPR019787
Domain	PHD	KMT2C KMT2D	1.41e-02	89	38	2	SM00249
Domain	Znf_PHD	KMT2C KMT2D	1.47e-02	91	38	2	IPR001965
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPRD PTPRF PTPRG	8.77e-07	17	39	3	19727691
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	1.23e-06	2	39	2	28483418
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	1.23e-06	2	39	2	36869380
Pubmed	The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.	PTPRD PTPRF	1.23e-06	2	39	2	7665159
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	1.23e-06	2	39	2	25346535
Pubmed	The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.	PCDH15 MYO15A	1.23e-06	2	39	2	24940003
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	1.23e-06	2	39	2	28967912
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	1.23e-06	2	39	2	31924266
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	1.23e-06	2	39	2	34156443
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	1.23e-06	2	39	2	27280393
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	1.23e-06	2	39	2	36601880
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRF	3.67e-06	3	39	2	31985401
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRF	3.67e-06	3	39	2	20139422
Pubmed	Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway.	PTPRD PTPRF	3.67e-06	3	39	2	25703008
Pubmed	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.	PTPRD PTPRF	3.67e-06	3	39	2	9784606
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRF	3.67e-06	3	39	2	33656439
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	3.67e-06	3	39	2	22183980
Pubmed	Identification of Pathogenic Genes of Nonsyndromic Hearing Loss in Uyghur Families Using Massively Parallel DNA Sequencing Technique.	PCDH15 MYO15A	3.67e-06	3	39	2	29692870
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	3.67e-06	3	39	2	23932714
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	3.67e-06	3	39	2	21683083
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	7.34e-06	4	39	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	7.34e-06	4	39	2	34645806
Pubmed	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.	PCDH15 MYO15A	7.34e-06	4	39	2	30275467
Pubmed	Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.	PCDH15 KMT2D	7.34e-06	4	39	2	16972005
Pubmed	The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.	PTPRD PTPRF	7.34e-06	4	39	2	8524829
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	7.34e-06	4	39	2	28398509
Pubmed	Control of stereocilia length during development of hair bundles.	PCDH15 MYO15A	7.34e-06	4	39	2	37011103
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	7.34e-06	4	39	2	23129768
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	7.34e-06	4	39	2	24081332
Pubmed	Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways.	CMIP PTPRD	7.34e-06	4	39	2	21493956
Pubmed	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.	PTPRD PTPRF	1.22e-05	5	39	2	22357843
Pubmed	Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.	PCDH15 SLC4A7	1.22e-05	5	39	2	16301216
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	1.22e-05	5	39	2	31127101
Pubmed	Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.	GALNT3 PTPRF	1.22e-05	5	39	2	9295285
Pubmed	Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.	PTPRD PTPRF	1.22e-05	5	39	2	10777529
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	1.22e-05	5	39	2	32601106
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	1.22e-05	5	39	2	26744420
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RIF1 PSMD7 KMT2D PTPRD PTPRF PTPRG PTPRT LTN1	1.79e-05	1049	39	8	27880917
Pubmed	Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.	PTPRD PTPRG	1.83e-05	6	39	2	2170109
Pubmed	Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.	PTPRD PTPRF	1.83e-05	6	39	2	19273906
Pubmed	Receptor protein tyrosine phosphatases are novel components of a polycystin complex.	PTPRD PTPRG	1.83e-05	6	39	2	21126580
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	1.83e-05	6	39	2	17021013
Pubmed	Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.	PTPRD PTPRF	2.56e-05	7	39	2	29073098
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	2.56e-05	7	39	2	36598580
Pubmed	Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse.	PCDH15 MYO15A	2.56e-05	7	39	2	16962269
Pubmed	Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat.	PTPRF PTPRG	2.56e-05	7	39	2	7804149
Pubmed	Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.	PTPRD PTPRF	2.56e-05	7	39	2	12376545
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	2.56e-05	7	39	2	19556342
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	2.56e-05	7	39	2	30604749
Pubmed	Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.	PCDH15 MYO15A	2.56e-05	7	39	2	21436032
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	CACNA1B KMT2C CMIP SLC4A7 PTPRD	2.93e-05	322	39	5	26514267
Pubmed	Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.	PCDH15 MYO15A	3.42e-05	8	39	2	35044843
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	3.42e-05	8	39	2	30335158
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D	3.42e-05	8	39	2	23130995
Pubmed	Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.	PCDH15 SLC4A7	3.42e-05	8	39	2	16545802
Pubmed	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.	PTPRD PTPRF	3.42e-05	8	39	2	28637841
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	3.42e-05	8	39	2	21447625
Pubmed	Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.	PTPRD PTPRF	3.42e-05	8	39	2	37591863
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D	3.42e-05	8	39	2	22266653
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	PCDH15 PTPRD PTPRG PTPRT	4.06e-05	171	39	4	20201926
Pubmed	Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.	SHISA9 PTPRD MCTP2	4.27e-05	60	39	3	23362303
Pubmed	Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.	PCDH15 KMT2D	4.39e-05	9	39	2	35296311
Pubmed	Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.	PCDH15 MYO15A	4.39e-05	9	39	2	19339464
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	PCDH15 MYO15A	4.39e-05	9	39	2	23144817
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D	4.39e-05	9	39	2	22665483
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	6.70e-05	11	39	2	37012455
Pubmed	PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.	PTPRD PTPRF	6.70e-05	11	39	2	25624497
Pubmed	A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.	PTPRD PTPRF	6.70e-05	11	39	2	7832766
Pubmed	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.	PTPRD PTPRF	8.03e-05	12	39	2	9624153
Pubmed	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.	PCDH15 MYO15A	8.03e-05	12	39	2	28663585
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D	8.03e-05	12	39	2	27563068
Pubmed	Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.	APBA2 MCTP2	8.03e-05	12	39	2	24009623
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	RIF1 PSMD7 MMS22L NUP160 TMED5 LTN1	8.52e-05	657	39	6	36180527
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D	9.48e-05	13	39	2	17761849
Pubmed	Differential gene expression in migrating cortical interneurons during mouse forebrain development.	PTPRD PTPRT	9.48e-05	13	39	2	20151419
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	9.48e-05	13	39	2	21502505
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	PCDH15 MYO15A	1.11e-04	14	39	2	26754646
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	1.11e-04	14	39	2	12482968
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2C KMT2D	1.27e-04	15	39	2	17925232
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2D	1.46e-04	16	39	2	24368734
Pubmed	Functional analysis of candidate genes from genome-wide association studies of hearing.	CMIP PTPRD	1.65e-04	17	39	2	31927188
Pubmed	A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.	APBA2 PTPRD	1.65e-04	17	39	2	22832960
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C KMT2D	1.65e-04	17	39	2	26180087
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C KMT2D	1.85e-04	18	39	2	17500065
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	PCDH15 PTPRD PTPRT	2.01e-04	101	39	3	18519826
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	PCDH15 KMT2C CFAP61 PTPRD	2.20e-04	265	39	4	19240061
Pubmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.	KMT2C KMT2D	2.30e-04	20	39	2	33431871
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C KMT2D	2.30e-04	20	39	2	29785026
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2C KMT2D	2.30e-04	20	39	2	19047629
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D	2.54e-04	21	39	2	27626377
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C KMT2D	2.79e-04	22	39	2	26886794
Pubmed	Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.	PCDH15 UNC5B	2.79e-04	22	39	2	29449449
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	CACNA1B GRIK5	3.33e-04	24	39	2	22534482
Pubmed	Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.	PTPRD PTPRF	3.91e-04	26	39	2	36178190
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	SLC4A7 PTPRF ICAM2	4.42e-04	132	39	3	26439863
Pubmed	Integrating genetic and network analysis to characterize genes related to mouse weight.	RIF1 GALNT3	4.88e-04	29	39	2	16934000
Pubmed	USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells.	RIF1 PSMD7	5.23e-04	30	39	2	31740976
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C KMT2D	5.58e-04	31	39	2	20516061
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR1L6 OR52B2 OR9Q1 OR5D13	5.82e-04	343	39	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR1L6 OR52B2 OR9Q1 OR5D13	6.02e-04	346	39	4	14611657
Interaction	IZUMO1 interactions	SLC4A7 PTPRD PTPRF	2.27e-05	31	36	3	int:IZUMO1
Interaction	SCN2B interactions	RIF1 PTPRD PTPRF NUP160	2.43e-05	95	36	4	int:SCN2B
Interaction	RND1 interactions	SLC4A7 PTPRF PTPRG UNC5B MYOM3	7.20e-05	246	36	5	int:RND1
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRF PTPRG PTPRT	5.38e-08	21	33	4	813
GeneFamily	Fibronectin type III domain containing	PTPRD PTPRF PTPRG PTPRT MYOM3	9.90e-06	160	33	5	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PTPRD PTPRF UNC5B MYOM3	2.03e-04	161	33	4	593
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D	1.75e-03	34	33	2	487
GeneFamily	Immunoglobulin like domain containing	PTPRT ICAM2 MYOM3	5.16e-03	193	33	3	594
GeneFamily	PHD finger proteins	KMT2C KMT2D	1.17e-02	90	33	2	88
GeneFamily	Actins\|Deafness associated genes	PCDH15 MYO15A	1.80e-02	113	33	2	1152
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	DNAAF11 CFAP61 DNAH12 PTPRT	1.91e-05	182	39	4	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	tumor_Lung-Epithelial_cells-tS3\|tumor_Lung / Location, Cell class and cell subclass	DNAAF11 CFAP61 DNAH12 PTPRT	2.17e-05	188	39	4	26326b4e298e33f9ba393fc632238aa8c54b1ea3
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAAF11 CFAP61 DNAH12 PTPRT	2.21e-05	189	39	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	COVID-19-Heart-T_cell\|Heart / Disease (COVID-19 only), tissue and cell type	PCDH15 APBA2 GALNT3 MCTP2	2.26e-05	190	39	4	e6c3a6e01fef6c5b49f72661d4fb0414ba9046bf
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAAF11 CFAP61 DNAH12 PTPRT	2.30e-05	191	39	4	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAAF11 CFAP61 DNAH12 PTPRT	2.30e-05	191	39	4	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAAF11 CFAP61 DNAH12 PTPRT	2.30e-05	191	39	4	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIF1 CMIP PTPRF PTPRG	2.35e-05	192	39	4	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	DNAAF11 CFAP61 DNAH12 PTPRT	2.35e-05	192	39	4	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAAF11 CFAP61 DNAH12 PTPRT	2.40e-05	193	39	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAAF11 CFAP61 DNAH12 PTPRT	2.40e-05	193	39	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FSIP2 CMIP GALNT3 PTPRF	2.45e-05	194	39	4	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FSIP2 CMIP GALNT3 PTPRF	2.45e-05	194	39	4	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C RIF1 SLC4A7 PTPRF	2.50e-05	195	39	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C RIF1 SLC4A7 PTPRF	2.50e-05	195	39	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DNAAF11 CFAP61 DNAH12 PTPRT	2.76e-05	200	39	4	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DNAAF11 CFAP61 DNAH12 PTPRT	2.76e-05	200	39	4	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Fos_(Deep_layer_pyramidal_cells--layer_5_(IEG))\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MMS22L GPRC5D GALNT3	4.21e-05	77	39	3	4879a1a72b950dadb78bc0312be75f1a32b935d5
ToppCell	LA-10._Endothelium_II\|World / Chamber and Cluster_Paper	SHISA9 CMIP ICAM2	1.91e-04	128	39	3	071becbe97598c2b65580b0989eb664d6fd6c85a
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PCDH15 CACNA1B PTPRT	1.91e-04	128	39	3	91072ca56bce2c552a95edd67e17f43d8cc1de95
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PCDH15 PTPRD PTPRT	2.43e-04	139	39	3	a1945b07f177cde40e7eea03a19236ce76165857
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDH15 CACNA1B MYO15A	2.75e-04	145	39	3	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	metastatic_Brain-T/NK_cells-Naive_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	DNAAF11 PTPRD LTN1	2.86e-04	147	39	3	4f7a0c287721befeffabf95b8c5f9ff64149c7c1
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PCDH15 CACNA1B PTPRT	2.92e-04	148	39	3	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PCDH15 CACNA1B PTPRT	3.04e-04	150	39	3	0205318a870e091add66ee4305747dda9f51510d
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	CFAP61 DNAH12 PTPRT	3.10e-04	151	39	3	8216462e723fec2797387929dde095370947e10a
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PCDH15 SHISA9 FSIP2	3.35e-04	155	39	3	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DNAH12 MCTP2 UNC5B	3.47e-04	157	39	3	f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B DNAAF11 CFAP61	3.47e-04	157	39	3	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DNAH12 MCTP2 UNC5B	3.47e-04	157	39	3	43a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	PCDH15 CACNA1B PTPRT	3.60e-04	159	39	3	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B PTPRG PTPRT	3.67e-04	160	39	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B PTPRG PTPRT	3.67e-04	160	39	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCDH15 CACNA1B PTPRT	4.16e-04	167	39	3	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B KMT2C PTPRT	4.23e-04	168	39	3	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAAF11 CFAP61 DNAH12	4.23e-04	168	39	3	fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAAF11 CFAP61 DNAH12	4.23e-04	168	39	3	7edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAAF11 CFAP61 DNAH12	4.31e-04	169	39	3	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAAF11 DNAH12 PTPRT	4.31e-04	169	39	3	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	Ciliated_cells-A-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	DNAAF11 DNAH12 PTPRT	4.38e-04	170	39	3	8b7ef1464ea589886b575ebad5447b085cbdcdba
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10\|TCGA-Brain / Sample_Type by Project: Shred V9	CFAP61 DNAH12 GALNT3	4.46e-04	171	39	3	74be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCDH15 PTPRD MYOM3	4.46e-04	171	39	3	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PCDH15 APBA2 PTPRT	4.46e-04	171	39	3	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC19A3 GALNT3 PTPRF	4.61e-04	173	39	3	81c36b9fe02c59099f080b2db02f4eaf2783911f
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	APBA2 CACNA1B MYOM3	4.77e-04	175	39	3	f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	APBA2 CACNA1B MYOM3	4.77e-04	175	39	3	7bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCell	PCW_13-14-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFAP61 DNAH12 PTPRT	4.77e-04	175	39	3	c82ec6deb6ccdd991a69a62b6d62d5b14c803d7a
ToppCell	PCW_13-14-Epithelial-Epithelial_ciliated\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFAP61 DNAH12 PTPRT	4.77e-04	175	39	3	b1369d2b74f461e6822d0c33e9b50fe0dfbceb54
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHISA9 MCTP2 PTPRT	4.85e-04	176	39	3	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFAP61 PTPRT OR9Q1	5.01e-04	178	39	3	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.01e-04	178	39	3	de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell	Ciliated_cells-A-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAAF11 DNAH12 PTPRT	5.09e-04	179	39	3	0e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHISA9 GRIK5 SLC4A7	5.09e-04	179	39	3	747a32460b257fffca30527b56a74720eb9c12e4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRT OR9Q1 MYOM3	5.09e-04	179	39	3	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	P03-Epithelial-airway_epithelial_cell-club_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAAF11 CFAP61 DNAH12	5.26e-04	181	39	3	60a91587c59029a34e7bec1255083337fe21b72a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PCDH15 PTPRD MYOM3	5.26e-04	181	39	3	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PCDH15 PTPRD MYOM3	5.26e-04	181	39	3	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHISA9 PTPRD MCTP2	5.26e-04	181	39	3	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.26e-04	181	39	3	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	P03-Epithelial-airway_epithelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAAF11 CFAP61 DNAH12	5.26e-04	181	39	3	1ea21d860d4d7abab3e21e130a16d044006656ee
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.35e-04	182	39	3	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC19A3 PTPRG ICAM2	5.35e-04	182	39	3	ccc313ecc0bfd8e2c6bb83a565b427b2310485ec
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHISA9 PTPRD MCTP2	5.35e-04	182	39	3	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC19A3 PTPRG ICAM2	5.35e-04	182	39	3	e6a734fb29105093d4cbfc3d0619a825b66da034
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC19A3 APBA2 ICAM2	5.35e-04	182	39	3	d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRD OR9Q1 MYOM3	5.35e-04	182	39	3	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC19A3 PTPRG ICAM2	5.35e-04	182	39	3	b9f758961fb4a586ae86fa0b25edb8ce4616d644
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC19A3 GALNT3 MYOM3	5.43e-04	183	39	3	0d21befacefc6c597e7b501ed41b7fe9385a78df
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDH15 PTPRD MYO15A	5.52e-04	184	39	3	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDH15 PTPRD MYO15A	5.52e-04	184	39	3	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDH15 PTPRD MYO15A	5.52e-04	184	39	3	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC19A3 GPRC5D PTPRF	5.52e-04	184	39	3	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	P07-Epithelial-airway_epithelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAAF11 CFAP61 DNAH12	5.52e-04	184	39	3	a5e7af3392e9d6ddad0397f1eeb6b91ed1107cc2
ToppCell	P07-Epithelial-airway_epithelial_cell-club_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAAF11 CFAP61 DNAH12	5.52e-04	184	39	3	ab469b9e06212462cbe2e4db8775c6778db855e6
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.52e-04	184	39	3	5daff849625f2f41d56615569c0ed59cd733b34c
ToppCell	droplet-Lung-nan-21m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC19A3 APBA2 UNC5B	5.61e-04	185	39	3	3a4ae836e882e8d29eb0a2dfab5677f10f2d365f
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.61e-04	185	39	3	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.61e-04	185	39	3	3e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	CFAP61 DNAH12 PTPRT	5.61e-04	185	39	3	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	MMS22L KMT2D MCTP2	5.61e-04	185	39	3	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	droplet-Lung-nan-21m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC19A3 APBA2 UNC5B	5.61e-04	185	39	3	224f0b022c21dd40bf1f7503f00b3107ef958975
ToppCell	15-Airway-Epithelial-Multiciliated_cell\|Airway / Age, Tissue, Lineage and Cell class	CFAP61 DNAH12 PTPRT	5.61e-04	185	39	3	0998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCell	P28-Epithelial-airway_epithelial_cell-club_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAAF11 CFAP61 DNAH12	5.69e-04	186	39	3	a26811481668fa25c48a064a56c198685693ad8d
ToppCell	P28-Epithelial-airway_epithelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAAF11 CFAP61 DNAH12	5.69e-04	186	39	3	df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRD OR9Q1 MYOM3	5.69e-04	186	39	3	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAAF11 DNAH12 PTPRT	5.69e-04	186	39	3	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPRD PTPRG MCTP2	5.69e-04	186	39	3	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CMIP PTPRT OR9Q1	5.69e-04	186	39	3	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 PTPRG MCTP2	5.78e-04	187	39	3	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PCDH15 GRIK5 PTPRD	5.78e-04	187	39	3	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	CMIP PTPRG ICAM2	5.78e-04	187	39	3	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC4A7 GALNT3 MCTP2	5.78e-04	187	39	3	d17352f769c3c66601b65d060626eecff41b0482
ToppCell	tumor_Lung-Epithelial_cells-tS3\|Epithelial_cells / Location, Cell class and cell subclass	DNAAF11 CFAP61 DNAH12	5.78e-04	187	39	3	3cea677279e71fdb9879530dea10a5e6393beacd
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.78e-04	187	39	3	9e10ed56090d82589bc457788282f664b70ace4b
ToppCell	COPD-Epithelial-Ciliated\|COPD / Disease state, Lineage and Cell class	CFAP61 DNAH12 PTPRT	5.78e-04	187	39	3	f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PCDH15 CMIP PTPRD	5.78e-04	187	39	3	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	Ciliated_cells-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	DNAAF11 DNAH12 PTPRT	5.78e-04	187	39	3	6fa38dbccca36bc7a4fef46de74c6688f599f421
ToppCell	P15-Epithelial-airway_epithelial_cell-club_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAAF11 CFAP61 DNAH12	5.78e-04	187	39	3	a70aaae32426e9ddb1cbfbd0e0db24ccc96b9f40
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 PTPRG MCTP2	5.87e-04	188	39	3	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	CFAP61 DNAH12 PTPRT	5.87e-04	188	39	3	34b11f72ca73153d02edcd09b38983ad1a504659
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	1.61e-06	2	38	2	DOID:0080598 (implicated_via_orthology)
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2C KMT2D PTPRT	2.69e-05	45	38	3	DOID:3748 (is_implicated_in)
Disease	Malignant neoplasm of stomach	KMT2C PTPRF PTPRG PTPRT ICAM2	4.01e-05	300	38	5	C0024623
Disease	endometrial carcinoma, endometriosis	PTPRD OR9Q1	8.82e-05	11	38	2	EFO_0001065, EFO_1001512
Disease	congenital heart disease (implicated_via_orthology)	KMT2C PSMD7 KMT2D	9.74e-05	69	38	3	DOID:1682 (implicated_via_orthology)
Disease	chronotype measurement	PCDH15 KMT2D CFAP61 PTPRD PTPRG UNC5B OR9Q1	1.17e-04	882	38	7	EFO_0008328
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	SHISA9 MMS22L KMT2D GALNT3 PTPRF	1.52e-04	398	38	5	EFO_0003756, EFO_0003888, EFO_0004337
Disease	short-term memory	PCDH15 DNAH12 PTPRD	1.69e-04	83	38	3	EFO_0004335
Disease	body weight	PCDH15 CACNA1B MMS22L GRIK5 DNAH12 PTPRG NUP160 PTPRT	1.69e-04	1261	38	8	EFO_0004338
Disease	fatty acid measurement	SHISA9 MMS22L GRIK5 CMIP PTPRD	2.31e-04	436	38	5	EFO_0005110
Disease	gastroesophageal reflux disease	MMS22L ANO10 PTPRT	3.01e-04	101	38	3	EFO_0003948
Disease	diffuse plaque measurement	SHISA9 GRIK5 CMIP ANO10 PTPRD PTPRG	3.86e-04	758	38	6	EFO_0010699
Disease	cognitive function measurement	SHISA9 MMS22L KMT2D DNAAF11 PTPRD GALNT3 PTPRF PTPRT	4.04e-04	1434	38	8	EFO_0008354
Disease	temperament and character inventory	APBA2 PTPRD	4.38e-04	24	38	2	EFO_0004825
Disease	pursuit maintenance gain measurement	GRIK5 CMIP PTPRD	5.36e-04	123	38	3	EFO_0008433
Disease	Hereditary Diffuse Gastric Cancer	KMT2C PTPRF PTPRG ICAM2	5.39e-04	293	38	4	C1708349
Disease	Sezary Syndrome	KMT2C KMT2D	5.55e-04	27	38	2	C0036920
Disease	azoospermia (implicated_via_orthology)	PTPRD PTPRF	5.55e-04	27	38	2	DOID:14227 (implicated_via_orthology)
Disease	Stomach Neoplasms	KMT2C PTPRF PTPRG ICAM2	5.67e-04	297	38	4	C0038356
Disease	non-alcoholic fatty liver disease severity measurement	PTPRD PTPRG	5.98e-04	28	38	2	EFO_0008421
Disease	blood viscosity	PTPRD PTPRF	7.33e-04	31	38	2	EFO_0004301
Disease	hip circumference	SHISA9 PTPRG PTPRT LTN1	9.18e-04	338	38	4	EFO_0005093
Disease	cardiac hypertrophy	PCDH15 GRIK5	9.35e-04	35	38	2	EFO_0002503
Disease	cognitive function measurement, self reported educational attainment	MMS22L GALNT3 PTPRF NUP160	1.10e-03	355	38	4	EFO_0004784, EFO_0008354
Disease	Parkinson disease, disease progression measurement	PTPRD MCTP2	1.16e-03	39	38	2	EFO_0008336, MONDO_0005180
Disease	free androgen index	CMIP PTPRF PTPRG NUP160	1.33e-03	374	38	4	EFO_0007005
Disease	risky sexual behaviour measurement	MMS22L GRIK5 PTPRF	1.34e-03	169	38	3	EFO_0007877
Disease	oral microbiome measurement	KMT2C GRIK5	1.35e-03	42	38	2	EFO_0801229
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement	CMIP PTPRD	1.41e-03	43	38	2	EFO_0007788, EFO_0008343
Disease	wellbeing measurement	SHISA9 MMS22L PTPRD PTPRG NUP160	1.85e-03	692	38	5	EFO_0007869
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	PCDH15 MYO15A	1.98e-03	51	38	2	cv:CN043650
Disease	neurofilament light chain measurement	CD1B MYO15A	2.46e-03	57	38	2	EFO_0009178

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTGTYIVIDSMLQQI	PTPRG	1066	P23470
VGIAVIRNEMDIEYI	CFAP61	521	Q8NHU2
SMVVIEVFTPVVQRI	CMIP	256	Q8IY22
TISYIADIGNIVVLM	APBA2	456	Q99767
REIVVGSNMDKIYIV	CDK11B	501	P21127
IIQYQGIMETVRILL	CD1B	166	P29016
IVTMRYFEVVILVVI	CACNA1B	1146	Q00975
MATYTIEDIVIELII	LTN1	1636	O94822
VPSIIYAIVIEIMNR	ANO10	361	Q9NW15
RVVSVLYTEVIPMLN	OR9Q1	271	Q8NGQ5
MVIEYIGTIIRNEVA	KMT2C	4796	Q8NEZ4
GLIERIYMVQDIVST	MCTP2	756	Q6DN12
VVMAQLRYSGVLETV	MYO15A	1811	Q9UKN7
ISVQGVILEEQLRMY	MMS22L	391	Q6ZRQ5
DIVESVLGKMYLVVV	FSIP2	2541	Q5CZC0
IVMVILDVILIAVSY	OR52B2	206	Q96RD2
IQDIIVPTMDTIRYT	DNAH12	1861	Q6ZR08
ASIVMVTNLVEVGRV	PTPRT	981	O14522
VEMIVGRTYALTVQA	PCDH15	571	Q96QU1
IIIATEYVTLIMTRG	GPRC5D	141	Q9NZD1
IIVLVLMQREVSVQY	GALNT3	31	Q14435
LIDVDVQPTYVRVMI	DNAAF11	331	Q86X45
TLVVTTILENPYVMR	GRIK5	416	Q16478
VIQTIMTVIVVDQRG	SLC19A3	416	Q9BZV2
TLSIVLERMRYEGVV	PTPRF	1851	P10586
VYTVTVVGNLGMIII	OR5D13	36	Q8NGL4
TLSIVLERMRYEGVV	PTPRD	1856	P23468
VRDRVATVMYTVVTP	OR1L6	306	Q8NGR2
LTIVIMVTIDYLVGV	SLC4A7	866	Q9Y6M7
QMVVVYLASLIRSVV	PSMD7	256	P51665
LFVDRIIYIITVMVD	RIF1	751	Q5UIP0
NLIVYIICGVVAVMV	SHISA9	151	B4DS77
STEQELMVVGRVFVV	SLC5A9	421	Q2M3M2
YEPVSDSQMVIIVTV	ICAM2	216	P13598
GVYVSETQNRVIILM	NUP160	141	Q12769
VNLVVMVVVSAIQVY	TMED5	201	Q9Y3A6
VVVAILMAVGVVVYR	UNC5B	386	Q8IZJ1
TMVIEYIGTIIRNEV	KMT2D	5421	O14686
YRMEVRGTEVTITIE	MYOM3	1381	Q5VTT5