Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-8 ERVK-19 ERVK-25

4.98e-06371365GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-8 ERVK-19 ERVK-25

5.70e-06381365GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-8

4.90e-05111363GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-8

1.06e-04141363GO:0003964
GeneOntologyMolecularFunctioncell adhesion mediator activity

CNTN4 CNTN6 AGER IGSF9 ROBO3

1.71e-04761365GO:0098631
GeneOntologyMolecularFunctionmyosin binding

TRPM7 GRIA1 ADGRV1 SPTBN5 DMD

2.89e-04851365GO:0017022
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-8

3.76e-04211363GO:0035613
GeneOntologyMolecularFunctionhistone H3K27me2/H3K27me3 demethylase activity

KDM6B KDM6A

4.54e-0451362GO:0071558
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGTLC2 GGT3P

6.78e-0461362GO:0000048
GeneOntologyMolecularFunctionkeratin filament binding

EPPK1 FAM83H

6.78e-0461362GO:1990254
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGTLC2 GGT3P

6.78e-0461362GO:0002951
GeneOntologyMolecularFunctioncell-cell adhesion mediator activity

CNTN4 CNTN6 IGSF9 ROBO3

7.95e-04611364GO:0098632
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM6B KDM6A HR

8.94e-04281363GO:0141052
GeneOntologyMolecularFunctionD-glucose:sodium symporter activity

SLC5A2 SLC5A11

9.46e-0471362GO:0005412
GeneOntologyMolecularFunctionhistone demethylase activity

KDM6B KDM6A HR

1.21e-03311363GO:0032452
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGTLC2 GGT3P

1.26e-0381362GO:0103068
GeneOntologyMolecularFunctionprotein demethylase activity

KDM6B KDM6A HR

1.33e-03321363GO:0140457
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGTLC2 GGT3P

1.61e-0391362GO:0036374
GeneOntologyBiologicalProcessaxon guidance

SEMA6B CNTN4 NTRK1 L1CAM EDNRA CNTN6 MAPK8IP3 SEMA5B LRP1 IGSF9 ROBO3

2.84e-0628513511GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

SEMA6B CNTN4 NTRK1 L1CAM EDNRA CNTN6 MAPK8IP3 SEMA5B LRP1 IGSF9 ROBO3

2.94e-0628613511GO:0097485
GeneOntologyBiologicalProcessdendrite self-avoidance

CNTN4 CNTN6 IGSF9 ROBO3

5.00e-06181354GO:0070593
GeneOntologyBiologicalProcessneuron projection development

SEMA6B CNTN4 FLNA NTRK1 L1CAM SARM1 OBSL1 TSC2 SPAG9 ADGRV1 CSMD3 EDNRA CNTN6 MAPK8IP3 SLC12A5 SEMA5B AGER LRP1 LRP6 IGSF9 DMD ROBO3 INPP5J

9.69e-06128513523GO:0031175
GeneOntologyBiologicalProcessserine family amino acid biosynthetic process

GGTLC2 GGT3P SEPHS2 AGXT

2.00e-05251354GO:0009070
GeneOntologyBiologicalProcessneuron recognition

CNTN4 L1CAM CNTN6 IGSF9 ROBO3

4.20e-05591355GO:0008038
GeneOntologyBiologicalProcesspeptide biosynthetic process

GGTLC2 GGT3P DMD KLK2

6.99e-05341354GO:0043043
GeneOntologyBiologicalProcessneuron projection morphogenesis

SEMA6B CNTN4 NTRK1 L1CAM SARM1 OBSL1 TSC2 SPAG9 EDNRA CNTN6 MAPK8IP3 SEMA5B LRP1 IGSF9 DMD ROBO3

7.23e-0580213516GO:0048812
GeneOntologyBiologicalProcessneuron development

SEMA6B CNTN4 FLNA NTRK1 L1CAM SARM1 OBSL1 TSC2 SPAG9 ADGRV1 CSMD3 EDNRA CNTN6 MAPK8IP3 SLC12A5 SEMA5B AGER LRP1 LRP6 IGSF9 DMD ROBO3 INPP5J

7.41e-05146313523GO:0048666
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-8

7.47e-05131353GO:0015074
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

SEMA6B CNTN4 NTRK1 L1CAM SARM1 OBSL1 TSC2 SPAG9 EDNRA CNTN6 MAPK8IP3 SEMA5B LRP1 IGSF9 DMD ROBO3

9.24e-0581913516GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

SEMA6B CNTN4 NTRK1 L1CAM SARM1 OBSL1 TSC2 SPAG9 EDNRA CNTN6 MAPK8IP3 SEMA5B LRP1 IGSF9 DMD ROBO3

1.02e-0482613516GO:0048858
GeneOntologyBiologicalProcesscysteine metabolic process

GGTLC2 GGT3P AGXT

1.44e-04161353GO:0006534
GeneOntologyBiologicalProcessserine family amino acid metabolic process

GGTLC2 GGT3P SEPHS2 AGXT

1.78e-04431354GO:0009069
GeneOntologyBiologicalProcesspeptide metabolic process

LVRN GGTLC2 GGT3P DMD KLK2

2.27e-04841355GO:0006518
GeneOntologyBiologicalProcessestablishment of blood-brain barrier

LRP6 LRP5 DMD

2.46e-04191353GO:0060856
GeneOntologyBiologicalProcesscell morphogenesis

SEMA6B CNTN4 FLNA NTRK1 L1CAM SARM1 OBSL1 TSC2 SPAG9 EDNRA CNTN6 MAPK8IP3 SEMA5B NBEAL2 LRP1 LRP6 IGSF9 DMD ROBO3

2.89e-04119413519GO:0000902
GeneOntologyBiologicalProcessaxon development

SEMA6B CNTN4 FLNA NTRK1 L1CAM TSC2 EDNRA CNTN6 MAPK8IP3 SEMA5B LRP1 IGSF9 ROBO3

3.08e-0464213513GO:0061564
GeneOntologyCellularComponentaxon

CNTN4 FLNA TRPM7 NTRK1 L1CAM SARM1 GRIA1 TSC2 CNTN6 MAPK8IP3 AGER SBF2 LRP1 IGSF9 DMD ROBO3 ATP2B3 INPP5J

1.94e-0589113618GO:0030424
DomainIg_I-set

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

8.47e-0819012911IPR013098
DomainI-set

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

8.47e-0819012911PF07679
DomainIGc2

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

7.16e-0723512911SM00408
DomainIg_sub2

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

7.16e-0723512911IPR003598
DomainCalx_beta

ADGRV1 FREM1 FREM2

2.62e-0591293IPR003644
DomainCalx-beta

ADGRV1 FREM1 FREM2

2.62e-0591293PF03160
DomainIG

CNTN4 NTRK1 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

3.57e-0542112912SM00409
DomainIg_sub

CNTN4 NTRK1 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

3.57e-0542112912IPR003599
DomainJIP_LZII

SPAG9 MAPK8IP3

4.73e-0521292IPR032486
DomainLRP5/6

LRP6 LRP5

4.73e-0521292IPR017049
DomainJIP_LZII

SPAG9 MAPK8IP3

4.73e-0521292PF16471
DomainLdl_recept_b

LRP1 LRP6 LRP5

1.11e-04141293PF00058
DomainLDLRB

LRP1 LRP6 LRP5

1.11e-04141293PS51120
Domainfn3

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 IGSF9 ROBO3

1.34e-041621297PF00041
DomainLY

LRP1 LRP6 LRP5

1.38e-04151293SM00135
DomainLDLR_classB_rpt

LRP1 LRP6 LRP5

1.38e-04151293IPR000033
DomainIG_LIKE

CNTN4 NTRK1 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

1.54e-0449112912PS50835
DomainIg-like_dom

CNTN4 NTRK1 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 ROBO3

1.93e-0450312912IPR007110
Domain-

CNTN4 FLNA NTRK1 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 EXOC2 ROBO3

1.99e-04663129142.60.40.10
DomainEGF

CUBN THBS2 HMCN1 LRP1 LRP6 LRP5

2.42e-041261296PF00008
DomainJNK/Rab-associated_protein-1_N

SPAG9 MAPK8IP3

2.81e-0441292IPR019143
DomainTRPM_tetra

TRPM6 TRPM7

2.81e-0441292PF16519
DomainJnk-SapK_ap_N

SPAG9 MAPK8IP3

2.81e-0441292PF09744
DomainTRPM_tetra

TRPM6 TRPM7

2.81e-0441292IPR032415
DomainFN3

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 IGSF9 ROBO3

3.02e-041851297SM00060
Domainig

CNTN4 OBSL1 TYRO3 HMCN1 BSG AGER SIGLEC1

3.55e-041901297PF00047
DomainImmunoglobulin

CNTN4 OBSL1 TYRO3 HMCN1 BSG AGER SIGLEC1

3.55e-041901297IPR013151
DomainIg-like_fold

CNTN4 FLNA NTRK1 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG AGER IGSF9 SIGLEC1 EXOC2 ROBO3

3.77e-0470612914IPR013783
DomainRH2

SPAG9 MAPK8IP3

4.67e-0451292PS51777
DomainRH1

SPAG9 MAPK8IP3

4.67e-0451292PS51776
DomainFN3

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 IGSF9 ROBO3

4.69e-041991297PS50853
Domain-

SEMA6B FBXW10B GRWD1 SPAG9 MAPK8IP3 SEMA5B NBEAL2 WDR24 DCAF7

5.14e-0433312992.130.10.10
DomainACTININ_2

FLNA SPTBN5 DMD

5.15e-04231293PS00020
DomainACTININ_1

FLNA SPTBN5 DMD

5.15e-04231293PS00019
DomainActinin_actin-bd_CS

FLNA SPTBN5 DMD

5.15e-04231293IPR001589
DomainWD40/YVTN_repeat-like_dom

SEMA6B FBXW10B GRWD1 SPAG9 MAPK8IP3 SEMA5B NBEAL2 WDR24 DCAF7

5.37e-043351299IPR015943
DomainJmjC

KDM6B KDM6A HR

5.86e-04241293PF02373
DomainFN3_dom

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 IGSF9 ROBO3

6.27e-042091297IPR003961
DomainAlpha_kinase

TRPM6 TRPM7

6.97e-0461292PF02816
DomainMHCK_EF2_kinase

TRPM6 TRPM7

6.97e-0461292IPR004166
DomainALPHA_KINASE

TRPM6 TRPM7

6.97e-0461292PS51158
DomainAlpha_kinase

TRPM6 TRPM7

6.97e-0461292SM00811
DomainGGT_peptidase

GGTLC2 GGT3P

9.72e-0471292IPR000101
DomainKOW

SUPT5H MRPL24

9.72e-0471292SM00739
DomainG_glu_transpept

GGTLC2 GGT3P

9.72e-0471292PF01019
DomainG_GLU_TRANSPEPTIDASE

GGTLC2 GGT3P

9.72e-0471292PS00462
DomainEGF

CUBN THBS2 FCGBP HMCN1 LRP1 LRP6 LRP5

1.24e-032351297SM00181
DomainCalx_beta

ADGRV1 FREM2

1.29e-0381292SM00237
DomainJMJC

KDM6B KDM6A HR

1.38e-03321293PS51184
DomainJmjC_dom

KDM6B KDM6A HR

1.38e-03321293IPR003347
DomainCH

CFAP47 FLNA SPTBN5 DMD

1.40e-03701294PF00307
Domain-

CFAP47 FLNA SPTBN5 DMD

1.48e-037112941.10.418.10
DomainJmjC

KDM6B KDM6A HR

1.51e-03331293SM00558
DomainCH

CFAP47 FLNA SPTBN5 DMD

1.64e-03731294PS50021
DomainEGF-like_Ca-bd_dom

CUBN THBS2 HMCN1 LRP1 LRP5

1.70e-031241295IPR001881
DomainEGF-like_dom

CUBN THBS2 FCGBP HMCN1 LRP1 LRP6 LRP5

1.73e-032491297IPR000742
DomainCH-domain

CFAP47 FLNA SPTBN5 DMD

1.81e-03751294IPR001715
Domain-

LRP1 LRP6 LRP5

2.45e-033912932.120.10.30
DomainKOW

SUPT5H MRPL24

2.50e-03111292IPR005824
DomainKOW

SUPT5H MRPL24

2.50e-03111292PF00467
DomainNA_SOLUT_SYMP_1

SLC5A2 SLC5A11

2.50e-03111292PS00456
DomainLDLR_class-A_CS

LRP1 LRP6 LRP5

2.64e-03401293IPR023415
DomainEGF_CA

CUBN THBS2 HMCN1 LRP1

2.98e-03861294PF07645
DomainEGF_dom

CUBN THBS2

2.99e-03121292IPR024731
DomainSSF

SLC5A2 SLC5A11

2.99e-03121292PF00474
DomainEGF_3

CUBN THBS2

2.99e-03121292PF12947
DomainNA_SOLUT_SYMP_2

SLC5A2 SLC5A11

2.99e-03121292PS00457
DomainNa/solute_symporter

SLC5A2 SLC5A11

2.99e-03121292IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A2 SLC5A11

2.99e-03121292PS50283
DomainLdl_recept_a

LRP1 LRP6 LRP5

3.70e-03451293PF00057
Domain6-blade_b-propeller_TolB-like

LRP1 LRP6 LRP5

3.93e-03461293IPR011042
Domain-

LRP1 LRP6 LRP5

3.93e-034612934.10.400.10
DomainLDLRA_1

LRP1 LRP6 LRP5

4.44e-03481293PS01209
DomainWD40_repeat_dom

FBXW10B GRWD1 SPAG9 MAPK8IP3 NBEAL2 WDR24 DCAF7

4.60e-032971297IPR017986
DomainLDrepeatLR_classA_rpt

LRP1 LRP6 LRP5

4.70e-03491293IPR002172
DomainLDLa

LRP1 LRP6 LRP5

4.70e-03491293SM00192
DomainLDLRA_2

LRP1 LRP6 LRP5

4.70e-03491293PS50068
DomainEGF_CA

CUBN HMCN1 LRP1 LRP5

4.93e-03991294PS01187
DomainEGF_3

CUBN THBS2 HMCN1 LRP1 LRP6 LRP5

5.86e-032351296PS50026
DomainTranslation_prot_SH3-like

SUPT5H MRPL24

6.02e-03171292IPR008991
DomainRib_L2_dom2

SUPT5H MRPL24

6.74e-03181292IPR014722
Domain-

SUPT5H MRPL24

6.74e-031812922.30.30.30
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

CNTN4 OBSL1 CNTN6 TYRO3 HMCN1 BSG IGSF9 SIGLEC1 ROBO3

1.89e-08162138925826454
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA6B FLNA EPPK1 L1CAM TSC2 KDM6B FAM83H MAPK8IP3 SEPHS2 FASN NBEAL2 SBF2 LRP5 SNAPC4 MBD5 TTC38 PKN3 WDR24 HR

8.52e-0811051381935748872
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-19

6.08e-075138312629516
Pubmed

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.

AGER SIGLEC1 DMD

1.21e-066138330955887
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

FLNA EPPK1 FREM2 CCT5 SUPT5H LRP1 DLD EXOC2

2.86e-06219138831353912
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

SEMA6B NTRK1 L1CAM CUBN SEMA5B IGSF9

7.62e-06117138617145500
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP6 LRP5

9.85e-0611138324639464
Pubmed

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.

TRPM6 TRPM7 NTRK1

1.31e-0512138319850157
Pubmed

A role for Nr-CAM in the patterning of binocular visual pathways.

CNTN4 L1CAM CNTN6

1.31e-0512138316701205
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19

1.31e-0512138314557543
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TRPM6 SLC25A24 FLNA GRWD1 BAZ1B APOB IDH3A PGK1 SLC5A2 EFTUD2 FASN CCT5 BSG SUPT5H SEC23IP DLD ATP2B3 DCAF7

1.46e-0514251381830948266
Pubmed

Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah-/-mdx Mice.

DMD CMAHP

1.56e-052138234294193
Pubmed

Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.

TRPM6 TRPM7

1.56e-052138216636202
Pubmed

A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy.

DMD CMAHP

1.56e-052138220668298
Pubmed

Rethinking isolated cleft lip and palate as a syndrome.

HMCN1 IGSF9

1.56e-052138229500156
Pubmed

Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.

LRP6 LRP5

1.56e-052138221887268
Pubmed

JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells.

KDM6B KDM6A

1.56e-052138231959746
Pubmed

PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.

LRP6 LRP5

1.56e-052138233136328
Pubmed

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.

LRP6 LRP5

1.56e-052138215084453
Pubmed

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.

TRPM6 TRPM7

1.56e-052138224858416
Pubmed

The Charcot-Marie-Tooth binary repeat contains a gene transcribed from the opposite strand of a partially duplicated region of the COX10 gene.

FBXW10B COX10

1.56e-05213829403059
Pubmed

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

KDM6B KDM6A

1.56e-052138225132549
Pubmed

Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.

TRPM6 TRPM7

1.56e-052138219149903
Pubmed

Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.

LRP6 LRP5

1.56e-052138233164872
Pubmed

Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.

TRPM6 TRPM7

1.56e-052138218365021
Pubmed

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy.

DMD CMAHP

1.56e-052138229912990
Pubmed

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.

SPAG9 MAPK8IP3

1.56e-052138233788575
Pubmed

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

TRPM6 TRPM7

1.56e-052138214976260
Pubmed

Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma.

KDM6B KDM6A

1.56e-052138228197626
Pubmed

LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.

LRP6 LRP5

1.56e-052138225902418
Pubmed

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport.

AGER LRP1

1.56e-052138226820600
Pubmed

Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.

TRPM6 TRPM7

1.56e-052138221602712
Pubmed

The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.

LRP6 LRP5

1.56e-052138230474181
Pubmed

Inhibition of KDM6 activity during murine ESC differentiation induces DNA damage.

KDM6B KDM6A

1.56e-052138226759175
Pubmed

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation.

KDM6B KDM6A

1.56e-052138226328764
Pubmed

In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.

LRP6 LRP5

1.56e-052138236552732
Pubmed

Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.

LRP6 LRP5

1.56e-052138225783012
Pubmed

Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.

LRP6 LRP5

1.56e-052138219147944
Pubmed

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.

LRP6 LRP5

1.56e-052138215537447
Pubmed

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.

LRP6 LRP5

1.56e-052138217335347
Pubmed

Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.

TRPM6 TRPM7

1.56e-052138225692682
Pubmed

Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.

KDM6B KDM6A

1.56e-052138227151432
Pubmed

Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation.

NPTX2 GRIA1

1.56e-052138238597235
Pubmed

The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.

TRPM6 TRPM7

1.56e-052138224385424
Pubmed

Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis.

A2ML1 LRP1

1.56e-052138218648652
Pubmed

KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.

KDM6B KDM6A

1.56e-052138225101834
Pubmed

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.

LRP6 LRP5

1.56e-052138219503830
Pubmed

LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.

LRP6 LRP5

1.56e-052138237202775
Pubmed

Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.

LRP6 LRP5

1.56e-052138220926594
Pubmed

Sodium-glucose cotransporter 2-mediated oxidative stress augments advanced glycation end products-induced tubular cell apoptosis.

SLC5A2 AGER

1.56e-052138223508966
Pubmed

Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.

LRP6 LRP5

1.56e-052138216355283
Pubmed

Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.

LRP6 LRP5

1.56e-052138228425175
Pubmed

Decreased plasma levels of soluble low density lipoprotein receptor-related protein-1 (sLRP) and the soluble form of the receptor for advanced glycation end products (sRAGE) in the clinical diagnosis of Alzheimer's disease.

AGER LRP1

1.56e-052138223228658
Pubmed

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.

SPAG9 MAPK8IP3

1.56e-052138231690808
Pubmed

Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer.

KDM6B KDM6A

1.56e-052138232929331
Pubmed

The channel kinases TRPM6 and TRPM7 are functionally nonredundant.

TRPM6 TRPM7

1.56e-052138216150690
Pubmed

Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.

LRP6 LRP5

1.56e-052138218350154
Pubmed

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP.

TRPM6 TRPM7

1.56e-052138228821869
Pubmed

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk.

LRP1 LRP6

1.56e-052138226031789
Pubmed

KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome.

KDM6B KDM6A

1.56e-052138222589717
Pubmed

Recent developments in intestinal magnesium absorption.

TRPM6 TRPM7

1.56e-052138218301276
Pubmed

The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.

TRPM6 TRPM7

1.56e-052138218675813
Pubmed

Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).

LRP6 LRP5

1.56e-052138233118644
Pubmed

Identification of genes showing differential expression in anorexia mutant mouse.

GRIA1 TYRO3

1.56e-052138212802202
Pubmed

Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons.

GRIA1 LRP1

1.56e-052138225500815
Pubmed

Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.

LRP6 LRP5

1.56e-052138218493104
Pubmed

KDM6A and KDM6B play contrasting roles in nuclear transfer embryos revealed by MERVL reporter system.

KDM6B KDM6A

1.56e-052138230389724
Pubmed

Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.

TRPM6 TRPM7

1.56e-052138228220887
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.56e-05213829060628
Pubmed

A homozygous mutation p.Arg2167Trp in FREM2 causes isolated cryptophthalmos.

FREM1 FREM2

1.56e-052138229688405
Pubmed

Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.

LRP6 LRP5

1.56e-052138230668923
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.56e-05213829460924
Pubmed

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

LRP6 LRP5

1.56e-052138222433869
Pubmed

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment.

DMD CMAHP

1.56e-052138230281092
Pubmed

Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.

TRPM6 TRPM7

1.56e-052138218192217
Pubmed

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.

LRP6 LRP5

1.56e-052138225802278
Pubmed

Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells.

KDM6B KDM6A

1.56e-052138230626691
Pubmed

Recovery of induced mutations for X chromosome-linked muscular dystrophy in mice.

PGK1 DMD

1.56e-05213822919177
Pubmed

Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.

KDM6B KDM6A

1.56e-052138230936419
Pubmed

Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming.

KDM6B KDM6A

1.56e-052138221245294
Pubmed

Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.

TRPM6 TRPM7

1.56e-052138226563869
Pubmed

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.

KDM6B KDM6A

1.56e-052138222907667
Pubmed

The Different Roles of The Channel-Kinases TRPM6 and TRPM7.

TRPM6 TRPM7

1.56e-052138226179995
Pubmed

Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.

TRPM6 TRPM7

1.56e-052138216075242
Pubmed

Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.

KDM6B KDM6A

1.56e-052138221209387
Pubmed

The Maternal Effect Genes UTX and JMJD3 Play Contrasting Roles in Mus musculus Preimplantation Embryo Development.

KDM6B KDM6A

1.56e-052138227384759
Pubmed

Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation.

KDM6B KDM6A

1.56e-052138234880105
Pubmed

Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.

TRPM6 TRPM7

1.56e-052138234326388
Pubmed

PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.

APOB PCSK7

1.56e-052138237967646
Pubmed

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.

LRP6 LRP5

1.56e-052138233545636
Pubmed

TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.

TRPM6 TRPM7

1.56e-052138229912157
Pubmed

Magnesium and its transporters in cancer: a novel paradigm in tumour development.

TRPM6 TRPM7

1.56e-052138222671428
Pubmed

Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons.

KDM6B KDM6A

1.56e-052138225552720
Pubmed

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.

LRP6 LRP5

1.56e-052138212579474
Pubmed

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.

KDM6B KDM6A

1.56e-052138218003914
Pubmed

Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study.

TRPM6 TRPM7

1.56e-052138220875900
Pubmed

Targeting RAGE as a potential therapeutic approach to Duchenne muscular dystrophy.

AGER DMD

1.56e-052138230085099
Pubmed

Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer.

KDM6B KDM6A

1.56e-052138227983522
Pubmed

Pioneering axons regulate neuronal polarization in the developing cerebral cortex.

CNTN4 L1CAM CNTN6

1.70e-0513138324559674
Pubmed

Genetic mapping of the mouse X chromosome in the region homologous to human Xq27-Xq28.

L1CAM PGK1 DMD

2.15e-051413831674728
CytobandXq28

FLNA MAGEA11 L1CAM PNMA6A ATP2B3

1.94e-041761375Xq28
CytobandEnsembl 112 genes in cytogenetic band chrXq28

FLNA MAGEA11 L1CAM PNMA6A ATP2B3

4.66e-042131375chrXq28
Cytoband15q21

TRPM7 SPTBN5

4.78e-0411137215q21
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

CNTN4 L1CAM OBSL1 CNTN6 TYRO3 HMCN1 BSG IGSF9 SIGLEC1 ROBO3

1.01e-081619310593
GeneFamilyImmunoglobulin like domain containing

CNTN4 NTRK1 OBSL1 TYRO3 BSG AGER IGSF9 ROBO3

6.84e-06193938594
GeneFamilyLow density lipoprotein receptors

LRP1 LRP6 LRP5

3.63e-0513933634
GeneFamilyFibronectin type III domain containing

CNTN4 L1CAM CNTN6 TYRO3 IGSF9 ROBO3

1.77e-04160936555
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGTLC2 GGT3P

1.97e-0313932564
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOB ADGRV1 CSMD3 FREM1 FREM2 HMCN1 DGKK DMD

8.51e-0818413382cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOB ADGRV1 CSMD3 FREM1 FREM2 HMCN1 DGKK DMD

8.51e-081841338ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOB ADGRV1 CSMD3 FREM1 FREM2 HMCN1 DGKK DMD

8.51e-0818413382b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTN4 ST8SIA1 CPED1 FREM1 EDNRA LRP1 DMD

1.96e-0619413376e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA CPED1 EDNRA THBS2 HMCN1 LRP1 DMD

2.09e-061961337fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA CPED1 EDNRA THBS2 HMCN1 LRP1 DMD

2.09e-061961337802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GRIA1 CPED1 FREM1 EDNRA THBS2 HMCN1 LRP1

2.39e-062001337cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPM6 GRIA1 MYCBPAP FREM2 LRP1 ROBO3

4.38e-061421336d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPM6 GRIA1 MYCBPAP FREM2 LRP1 ROBO3

4.38e-061421336a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellLA-06._Ventricular_Cardiomyocyte_II|LA / Chamber and Cluster_Paper

L1CAM PMEL FDXR DMD WDR24

8.37e-06921335fad2e02ae858e3a9bbe51ad1c689f7e31d11ce0e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LVRN GRIA1 THBS2 FASN LRP1 DMD

9.01e-061611336a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRV1 CSMD3 CNTN6 FREM2 SIGLEC1 ATP2B3

9.34e-061621336bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

L1CAM GRIA1 AMER3 PRR25 CSMD3 ATP2B3

1.04e-0516513369795ce31689bc63f5a2d68725ef00b23a90c3846
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CPED1 FREM1 FREM2 THBS2 SEMA5B DMD

1.27e-0517113364ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

FLNA L1CAM CPED1 EDNRA SEMA5B DMD

1.31e-051721336c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TRPM7 FCGBP HMCN1 LRP6 INPP5J

1.36e-0517313360c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

APOB ADGRV1 GGTLC2 AGER IGSF9 RNF128

1.40e-051741336edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

APOB ADGRV1 GGTLC2 AGER IGSF9 RNF128

1.40e-05174133665539f69100db0b7d90b1b39ee15ab8281f86461
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 GGTLC2 CUBN SLC5A11 AGXT TTC38

1.54e-0517713362f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 GGTLC2 CUBN SLC5A2 SLC5A11 TTC38

1.75e-0518113369542c19edc9bd2cba68c01c2a8407705398e3011
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 GGTLC2 CUBN SLC5A2 SLC5A11 TTC38

1.75e-0518113368f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 GGTLC2 CUBN SLC5A11 AGXT TTC38

1.86e-05183133685446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCellHealthy-HSPC|World / disease group, cell group and cell class

NPTX2 OBSL1 CREB3L4 FREM1 SLC12A5 ZNF711

2.11e-0518713368cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TRPM7 FREM1 ITPKB HMCN1 INPP5J

2.17e-051881336bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 GGTLC2 CUBN SLC5A2 SLC5A11 TTC38

2.17e-051881336f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TRPM7 FREM1 ITPKB HMCN1 INPP5J

2.17e-051881336eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST8SIA1 CNTN6 OPRL1 SEMA5B LRP1 RNF128

2.17e-051881336a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST8SIA1 CNTN6 OPRL1 SEMA5B LRP1 RNF128

2.17e-051881336c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 GGTLC2 CUBN SLC5A2 SLC5A11 TTC38

2.17e-0518813360792432cd4c564dea1102241ea9884f7ced7658c
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMEL CNTN6 OPRL1 SEMA5B LRP1 RNF128

2.30e-0519013369b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMEL CNTN6 OPRL1 SEMA5B LRP1 RNF128

2.30e-051901336d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTN4 ST8SIA1 CPED1 FREM1 EDNRA LRP1

2.44e-0519213363d0cb19f037f604253d7d728689aeaa94251e92b
ToppCellLPS-IL1RA-Stromal_mesenchymal|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTN4 ST8SIA1 CPED1 FREM1 THBS2 LRP1

2.44e-0519213364e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CNTN4 FLNA CPED1 THBS2 SEMA5B DMD

2.52e-051931336000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

GRIA1 ST8SIA1 FREM1 EDNRA THBS2 HMCN1

2.52e-051931336ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTN4 ST8SIA1 CPED1 FREM1 EDNRA LRP1

2.52e-051931336fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA CPED1 EDNRA THBS2 LRP1 DMD

2.67e-05195133649c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA CPED1 EDNRA THBS2 LRP1 DMD

2.67e-051951336dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA CPED1 EDNRA THBS2 LRP1 DMD

2.67e-051951336edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCellP03-Mesenchymal|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FLNA B3GNT9 CPED1 FREM1 EDNRA LRP1

2.67e-0519513366180309c6ae278b996fd98c57461cbc129c028ba
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_3|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

RNF25 CNTN6 SPTBN5 ZNF469 LOXL4 IGSF9

2.82e-0519713364f8f23b1ef2eae9d300bd2c1a5cb7ef0163858a1
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Basal_3|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

RNF25 CNTN6 SPTBN5 ZNF469 LOXL4 IGSF9

2.82e-0519713362cff37f9d33951840a8f52ccbba6ca1a4bbe3ad9
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNF25 CNTN6 SPTBN5 ZNF469 LOXL4 IGSF9

2.82e-0519713360f37afad46b94c748a149d9ee681472d7a3e6937
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Mucous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF202 CREB3L4 SLC5A2 FCGBP TSPAN10 HR

2.90e-0519813362ae9564da9913510141994262f3739eb095e0a68
ToppCellCaecum-(6)_Macrophage-(61)_LYVE1_Macrophage|Caecum / shred on region, Cell_type, and subtype

COL8A2 CPED1 SLC12A5 FCGBP LRP1 SIGLEC1

2.90e-051981336e684c3934c163aef4d284b69435832d2c9614f2a
ToppCellCaecum-Macrophage-LYVE1_Macrophage|Caecum / Region, Cell class and subclass

COL8A2 CPED1 SLC12A5 FCGBP LRP1 SIGLEC1

2.90e-051981336a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_Myelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KIAA1614 SPTBN5 BSG A2ML1 MRPL24 HR

2.99e-0519913364e4bdcd2e8b518156d5ebd294804180acaa3566b
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GRIA1 CPED1 FREM1 THBS2 HMCN1 LRP1

3.07e-052001336389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNA CPED1 EDNRA TYRO3 SEMA5B DMD

3.07e-052001336c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GRIA1 ST8SIA1 CPED1 FREM1 HMCN1 LRP1

3.07e-0520013363dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CPED1 FREM1 EDNRA THBS2 HMCN1 LRP1

3.07e-05200133658b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell356C-Epithelial_cells-Epithelial-E_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF202 CNTN6 ZNF469 HMCN1 AGER

6.56e-05141133531e0984f09983e83a814424f74c871c1c5a3a789
ToppCell356C-Epithelial_cells-Epithelial-E_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF202 CNTN6 ZNF469 HMCN1 AGER

6.56e-051411335d7d3c3932651d90fa4f3c4e3df16f4b677faaf9f
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRWD1 ZNF711 PHF3 DHX35 RBM8A

6.78e-051421335b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRV1 CSMD3 CNTN6 FREM2 ATP2B3

7.49e-05145133596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA CPED1 EDNRA THBS2 DMD

1.06e-041561335d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA CPED1 EDNRA THBS2 DMD

1.06e-041561335363f1b661048d25895e2b8681c82894c957b29c0
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LVRN TRPM6 TRPM7 HMCN1 INPP5J

1.06e-0415613354d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM6 CNTN4 ANKRD65 CNTN6 LOXL4

1.09e-0415713356ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CPED1 FAM83H SLC5A2 SEMA5B DMD

1.09e-041571335f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCellRV-13._Vascular_Smooth_Muscle|RV / Chamber and Cluster_Paper

CNTN4 FLNA EPPK1 EDNRA DMD

1.23e-04161133547b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCellBasal_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

TRPM6 FBXW10B EPPK1 GRIA1 APOB

1.30e-041631335679e25e5548d157d49a73057a3b5617dccda260f
ToppCellLA-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

L1CAM FDXR DMD WDR24

1.40e-048813347232b13a9788f89600411222c0d93bdc3788816f
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NTRK1 CPED1 THBS2 ZNF469 LOXL4

1.54e-041691335031465190cd3623a25ef2b868daab8d932c8ff08
ToppCellmild_COVID-19-HSPC|World / disease group, cell group and cell class (v2)

NPTX2 OBSL1 ZNF711 IGSF9 INPP5J

1.58e-04170133585c476e0bc496445e868a88849960598d97bdea2
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10|TCGA-Brain / Sample_Type by Project: Shred V9

CFAP47 COL8A2 ACACB MYCBPAP ITPKB

1.62e-04171133574be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPTX2 SPTBN5 TYRO3 SEMA5B ROBO3

1.62e-041711335d07e2c5f7d7f12c68860d4161d76372de174f1d8
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NTRK1 CPED1 THBS2 ZNF469 LOXL4

1.62e-04171133515cb4670ff4234ac46aea8a5911138d6913c4482
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRPM7 EDNRA ZNF711 HMCN1 LRP5

1.67e-04172133580b565f6e37f38629f4cf89d5b053b3b8517244e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ACACB TRPM7 ITPKB HMCN1

1.71e-0417313354bc6d93716f093b460c8b047199db8cab5fea720
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3|TCGA-Breast / Sample_Type by Project: Shred V9

LVRN ACACB FREM1 FAM13A DMD

1.76e-0417413357f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCellTCGA-Breast-Solid_Tissue_Normal|TCGA-Breast / Sample_Type by Project: Shred V9

LVRN ACACB FREM1 FAM13A DMD

1.76e-041741335e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

LVRN ACACB FREM1 FAM13A DMD

1.76e-0417413350f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

LVRN ACACB FREM1 FAM13A DMD

1.76e-0417413351aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CFAP47 EPPK1 MYCBPAP CFAP77 CCDC17

1.81e-041751335c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELA2A ADGRV1 CSMD3 FREM1 HMCN1

1.81e-041751335887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 CPED1 HMCN1 DMD KDM6A

1.86e-041761335749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FREM1 CNTN6 FAM13A PHF3 MBD5

1.91e-041771335b7fee75de7e96924af488a5baa2334711889ae7c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TRPM7 COX7B FREM1 ITPKB

1.91e-041771335dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCellfacs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A24 L1CAM NBEAL2 MBD5 CMAHP

1.91e-041771335f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

EDNRA THBS2 ZNF469 HMCN1 LRP1

1.96e-041781335142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTN4 CUBN SLC5A2 SLC5A11 FREM2

1.96e-04178133523a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TRPM7 FREM1 ITPKB HMCN1

2.01e-041791335666072c0e8448dbaec1683d18368ec2502453f90
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSC2 EDNRA OPRL1 SEMA5B PCSK7

2.06e-041801335a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSC2 EDNRA OPRL1 SEMA5B PCSK7

2.06e-04180133563a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

COL8A2 ST8SIA1 OPRL1 LRP6 LOXL4

2.06e-041801335886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNA CPED1 KIAA1614 EDNRA DMD

2.11e-041811335fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IDH3A AGER NBEAL2 SPSB2 WDR24

2.11e-041811335f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ACACB TRPM7 ITPKB HMCN1

2.11e-041811335e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GRIA1 ST8SIA1 FREM1 EDNRA HMCN1

2.11e-0418113359ede19228ba5c0668a9c06c915510b95585216ef
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTN4 CUBN SLC5A2 SLC5A11 FREM2

2.11e-0418113356980ea624151da32b7f537f263e40fcb87a02e81
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2|Striatum / BrainAtlas - Mouse McCarroll V32

PMEL FAM83H SLC5A2 FCGBP

2.13e-049813347a62a77ca83153dacff4d02d6e32104227d0980d
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocye.Tnr.Pdgfa_(Pdgfa)|Striatum / BrainAtlas - Mouse McCarroll V32

PMEL FAM83H SLC5A2 FCGBP

2.13e-0498133426250ea4171a0557a67505839cf79d3fe4d9d41a
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr|Striatum / BrainAtlas - Mouse McCarroll V32

PMEL FAM83H SLC5A2 FCGBP

2.13e-0498133442875d16ae9fcbaf988cd71be82568f2f862f2dd
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL8A2 POU6F1 HMCN1 GLI4 SNAPC4

2.17e-041821335f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TRPM7 ITPKB HMCN1 INPP5J

2.22e-0418313352f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRV1 GGTLC2 CUBN SLC5A11 AGXT

2.22e-041831335d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TRPM7 FREM1 ITPKB HMCN1

2.22e-0418313352e831a4d99c6f983793df71c0994124c943c6da9
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

B3GNT9 CPED1 THBS2 ZNF469 LRP1

2.28e-04184133501257e5c12e38b849fd3d9496c43ded666249ba5
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTN4 CPED1 EDNRA LRP6 DMD

2.28e-041841335689a8af81a79a4bb3123cfa01958c953eab5de98
Drug5-(2-chlorophenyl)-2-furoic acid

FLNA COL8A2 NTRK1 TSC2 SLC12A5 LRP5

2.73e-07471306CID000784625
DrugMethamphetamine

FLNA NPTX2 ACACB SARM1 OBSL1 BAZ1B COX10 GRIA1 SPAG9 IDH3A CUBN KDM6B PGK1 MAPK8IP3 OPRL1 FCGBP CCT5 SUPT5H LRP1 DLD DMD KDM6A PKN3 HR

1.18e-06140113024ctd:D008694
DiseaseMarles Greenberg Persaud syndrome

FREM1 FREM2

1.81e-0521262C1855425
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

PDXDC1 ACACB SARM1 APOB OPRL1 FAM13A SBF2 PCSK7

2.57e-052761268EFO_0004612, EFO_0020943
DiseaseCongenital small ears

EDNRA EFTUD2 FREM2 KDM6A

2.84e-05411264C0152423
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

PDXDC1 L1CAM TSC2 CSMD3 PGK1 KDM6A

4.32e-051481266C0279702
Diseasefree cholesterol measurement, high density lipoprotein cholesterol measurement

PDXDC1 SARM1 OBSL1 APOB FAM13A SBF2 PCSK7 CMAHP

6.51e-053151268EFO_0004612, EFO_0008591
DiseaseFraser syndrome (implicated_via_orthology)

FREM1 FREM2

1.08e-0441262DOID:0090001 (implicated_via_orthology)
Diseasetuberous sclerosis (is_marker_for)

FLNA TSC2

1.08e-0441262DOID:13515 (is_marker_for)
Diseasemuscular disease (implicated_via_orthology)

ACACB FASN

1.79e-0451262DOID:0080000 (implicated_via_orthology)
DiseaseMacrothrombocytopenia

FLNA TRPM7

1.79e-0451262C2751260
DiseaseColorectal Carcinoma

CNTN4 TRPM7 APOB CUBN CSMD3 SLC12A5 CFAP77 LRP1 DMD KDM6A HR

2.19e-0470212611C0009402
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

PDXDC1 ACACB APOB OPRL1 FAM13A PCSK7

2.65e-042061266EFO_0004612, EFO_0020947
DiseaseMorphine Abuse

GRIA1 OPRL1

3.75e-0471262C0600272
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGTLC2 GGT3P

3.75e-0471262DOID:5022 (biomarker_via_orthology)
DiseaseMorphine Dependence

GRIA1 OPRL1

3.75e-0471262C0026552
DiseaseMASA syndrome (implicated_via_orthology)

TRPM7 L1CAM

3.75e-0471262DOID:0060246 (implicated_via_orthology)
Diseasephospholipid measurement, high density lipoprotein cholesterol measurement

PDXDC1 SARM1 OBSL1 APOB FAM13A SBF2 PCSK7

4.72e-043211267EFO_0004612, EFO_0004639
Diseasealcohol dependence (biomarker_via_orthology)

GGTLC2 GGT3P

4.98e-0481262DOID:0050741 (biomarker_via_orthology)
DiseaseUnilateral agenesis of kidney

FREM1 FREM2

4.98e-0481262C0266294
Diseasecalpastatin measurement

SARM1 SIGLEC1

4.98e-0481262EFO_0008065
Diseasefree cholesterol:total lipids ratio, intermediate density lipoprotein measurement

PDXDC1 ACACB SARM1 APOB

5.14e-04861264EFO_0008595, EFO_0020945
Diseaselipid measurement, high density lipoprotein cholesterol measurement

PDXDC1 SARM1 OBSL1 APOB FAM13A SBF2 PCSK7

5.57e-043301267EFO_0004529, EFO_0004612
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

ACACB SARM1 APOB OPRL1 FAM13A PCSK7

6.34e-042431266EFO_0004612, EFO_0020944
Diseasepulse pressure measurement

TRPM7 CELA2A KDM6B EDNRA OPRL1 SLC5A11 THBS2 FASN FAM13A SBF2 LRP1 LOXL4 ROBO3 MBD5 CMAHP

8.95e-04139212615EFO_0005763
Diseasepulmonary function measurement, smoking behaviour measurement, FEV/FEC ratio

FAM13A AGER LRP1

1.07e-03471263EFO_0003892, EFO_0004713, EFO_0005671
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

PDXDC1 ACACB APOB PCSK7

1.13e-031061264EFO_0008317, EFO_0008596
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

FREM1 LRP1

1.16e-03121262DOID:3827 (implicated_via_orthology)
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

PDXDC1 ACACB SARM1 APOB OPRL1 PCSK7

1.18e-032741266EFO_0004530, EFO_0004612
Diseasecholesteryl ester 20:3 measurement

PDXDC1 CNTN4 APOB

1.21e-03491263EFO_0010347
Diseasecholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

PDXDC1 ACACB APOB PCSK7

1.29e-031101264EFO_0008317, EFO_0008596, EFO_0010351
Diseasefree cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

PDXDC1 ACACB APOB PCSK7

1.29e-031101264EFO_0008317, EFO_0008591, EFO_0008596
Diseasechylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement

PDXDC1 ACACB APOB PCSK7

1.29e-031101264EFO_0004574, EFO_0008317, EFO_0008596
Diseasehair colour measurement

ADGRV1 FREM2 ZNF469 FAM13A TSPAN10 SBF2 LRP1 LRP5 EXOC2

1.33e-036151269EFO_0007822
Diseasepulmonary function measurement, FEV/FEC ratio

FAM13A AGER LRP1

1.52e-03531263EFO_0003892, EFO_0004713
Diseaseurate measurement

BAZ1B ADGRV1 CUBN FAM13A ALDH16A1 SBF2 LRP1 RBM8A MBD5 CMAHP CCDC17

1.61e-0389512611EFO_0004531
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

PDXDC1 ACACB APOB OPRL1 PCSK7

1.71e-032001265EFO_0004611, EFO_0020945
Diseasemetabolic syndrome

PDXDC1 BAZ1B APOB OPRL1 TYRO3

1.71e-032001265EFO_0000195
Diseasechronic lymphocytic leukemia

FREM1 FASN SEC23IP EXOC2

1.72e-031191264EFO_0000095
Diseasefree cholesterol to total lipids in large HDL percentage

PDXDC1 APOB SLC12A5

1.79e-03561263EFO_0022279
DiseaseWithdrawal Symptoms

NPTX2 GRIA1 OPRL1

1.98e-03581263C0087169
DiseaseDrug Withdrawal Symptoms

NPTX2 GRIA1 OPRL1

1.98e-03581263C0086189
DiseaseSubstance Withdrawal Syndrome

NPTX2 GRIA1 OPRL1

1.98e-03581263C0038587
DiseaseNeuralgia, Supraorbital

NTRK1 AGER

2.09e-03161262C0038870
DiseaseNeuralgia

NTRK1 AGER

2.09e-03161262C0027796
DiseaseDiabetic Angiopathies

THBS2 AGER

2.09e-03161262C0011875
DiseaseNeuralgia, Atypical

NTRK1 AGER

2.09e-03161262C0234247
DiseaseNeuralgia, Stump

NTRK1 AGER

2.09e-03161262C0234249
DiseaseMicroangiopathy, Diabetic

THBS2 AGER

2.09e-03161262C0025945
DiseaseNeuralgia, Iliohypogastric Nerve

NTRK1 AGER

2.09e-03161262C0423712
DiseaseNeuralgia, Perineal

NTRK1 AGER

2.09e-03161262C0423711
DiseaseParoxysmal Nerve Pain

NTRK1 AGER

2.09e-03161262C0751373
DiseaseNerve Pain

NTRK1 AGER

2.09e-03161262C0751372
DiseaseNeuralgia, Ilioinguinal

NTRK1 AGER

2.09e-03161262C0751371
DiseaseNeuralgia, Vidian

NTRK1 AGER

2.09e-03161262C0042656
Diseasephospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

PDXDC1 SARM1 APOB OPRL1 FAM13A PCSK7

2.10e-033071266EFO_0004612, EFO_0020946
Diseasecholesterol to total lipids in IDL percentage

PDXDC1 APOB PCSK7

2.18e-03601263EFO_0022233
DiseaseSarcomatoid Renal Cell Carcinoma

PDXDC1 L1CAM CSMD3 PGK1

2.25e-031281264C1266043
DiseaseChromophobe Renal Cell Carcinoma

PDXDC1 L1CAM CSMD3 PGK1

2.25e-031281264C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

PDXDC1 L1CAM CSMD3 PGK1

2.25e-031281264C1266044
DiseasePapillary Renal Cell Carcinoma

PDXDC1 L1CAM CSMD3 PGK1

2.25e-031281264C1306837
DiseaseRenal Cell Carcinoma

PDXDC1 L1CAM CSMD3 PGK1

2.25e-031281264C0007134
Diseasecholesteryl ester measurement, high density lipoprotein cholesterol measurement

PDXDC1 SARM1 APOB FAM13A SBF2 PCSK7

2.27e-033121266EFO_0004612, EFO_0010351
DiseaseVan Buchem disease

FLNA LRP5

2.36e-03171262C0432272
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

PDXDC1 SARM1 APOB FAM13A SBF2 PCSK7

2.38e-033151266EFO_0004574, EFO_0004612
Diseasefree cholesterol in very large HDL measurement

PDXDC1 APOB SLC12A5

2.39e-03621263EFO_0022273
Diseasesphingosine 1-phosphate measurement

DMD KDM6A

2.65e-03181262EFO_0800185
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

PDXDC1 ACACB APOB OPRL1 PCSK7

2.80e-032241265EFO_0004530, EFO_0008317
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

PDXDC1 ACACB BAZ1B APOB PCSK7

2.85e-032251265EFO_0008317, EFO_0010351
Diseasecerebral infarction (is_marker_for)

APOB AGER

2.95e-03191262DOID:3526 (is_marker_for)
DiseaseAlopecia

EDNRA HR

2.95e-03191262C0002170
Diseasetriglycerides to phosphoglycerides ratio

PDXDC1 APOB PCSK7

3.11e-03681263EFO_0022327
Diseasetotal cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer

BAZ1B APOB SEMA5B

3.24e-03691263EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Diseaseperiodontitis (biomarker_via_orthology)

NTRK1 AGER

3.60e-03211262DOID:824 (biomarker_via_orthology)
Diseasedocosahexaenoic acid to total fatty acids percentage

PDXDC1 APOB

3.60e-03211262EFO_0022262
Diseasetriglyceride measurement, phospholipid measurement

PDXDC1 ACACB APOB PCSK7

3.61e-031461264EFO_0004530, EFO_0004639
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

PDXDC1 SARM1 APOB PCSK7 CMAHP

3.69e-032391265EFO_0008317, EFO_0020945
Diseaseosteoporosis

ADGRV1 IDH3A LRP5

3.80e-03731263EFO_0003882
DiseaseLewy Body Disease

NTRK1 AGER

3.95e-03221262C0752347
Diseaseosteoporosis (biomarker_via_orthology)

AGER LRP5

3.95e-03221262DOID:11476 (biomarker_via_orthology)
Diseaseserum albumin measurement

PDXDC1 SPAG9 ADGRV1 CATSPER2 SEMA5B ALDH16A1 SBF2 EXOC2

3.98e-035921268EFO_0004535
Diseasealkaline phosphatase measurement

ACACB BAZ1B TSC2 APOB KIAA1614 ITPKB SLC12A5 PHKB CATSPER2 N4BP2L2 CMAHP

4.22e-03101512611EFO_0004533

Protein segments in the cluster

PeptideGeneStartEntry
RVEPTGLGVQAWASV

AMER3

756

Q8N944
PGVLGQIWQLQVEAS

CCDC17

261

Q96LX7
GVADGLANLNPVTWV

ERVK-19

616

O71037
GVADGLANLNPVTWV

ERVK-8

616

Q902F8
GVPEAIGRWNVFKQQ

CFAP77

131

Q6ZQR2
PEVVVLVGVTGQSVW

CATSPER2

191

Q96P56
VWKITVPEGAGIQVQ

CSMD3

1966

Q7Z407
TGQTVLVVGGVQWLN

CPED1

851

A4D0V7
QVGTVWINAHGLRDP

ALDH16A1

446

Q8IZ83
ALRAGTGENAPWVVE

BAZ1B

261

Q9UIG0
AFWGNVEVGRDVTVP

FDXR

106

P22570
NRIAQWLEVVPEQGI

A2ML1

166

A8K2U0
SLGQVAVEWRVVGGT

ADGRV1

2616

Q8WXG9
VIRTFPGRGNVTVNW

ADGRV1

2726

Q8WXG9
PGRGNVTVNWKIIGQ

ADGRV1

2731

Q8WXG9
LLGEIQVNWETVGPN

ADGRV1

4546

Q8WXG9
VIQARTPFSVGWQAV

CNTN4

631

Q8IWV2
SIANTWVGAVVGAIP

COX10

281

Q12887
AVASWSRVQGIGIPL

EDNRA

186

P25101
VTRVVGGEEARPNSW

CELA2A

26

P08217
RQAEVIKGSWQPVGD

DMD

2951

P11532
TGNATVGRVPVDDVW

LVRN

166

Q6Q4G3
VATQVGIEWNLSPVG

COX7B

56

P24311
TIWGLETGQVLGRVN

DCAF7

146

P61962
VGELVWGQVIATIPT

ATP2B3

1046

Q16720
LWGAVVGAQNITARI

AGER

16

Q15109
NVTLQIWDIGGQTIG

RAB28

61

P51157
PQRSVEGWILFVTGV

RBM8A

66

Q9Y5S9
NRLWVGTGNGVIISI

SPAG9

1156

O60271
APWAQTVVTGRARLG

ACACB

2076

O00763
RINVGWNGIEPSATA

FBXW10B

681

O95170
PVVVWEKGGQQLAAS

OBSL1

41

O75147
AVVQAIVRTAGGWAA

GGT3P

541

A6NGU5
IPVQVDGEAWIQRPG

DGKK

1006

Q5KSL6
QVEGRGLEQAGWILT

NTRK1

216

P04629
GVGLVRTVEWGQLPA

KLHL33

241

A6NCF5
GAVPLIQSRIVGGWE

KLK2

16

P20151
VQVEVNGVPRWGSVC

LOXL4

436

Q96JB6
QRITGGEQVLWGPIT

MAGEA11

81

P43364
RLWVGTGNGVVISIP

MAPK8IP3

1156

Q9UPT6
GINRVRVSWLGEEPV

GRWD1

151

Q9BQ67
GTIVEERVNRPGWNE

SBF2

1066

Q86WG5
VRQAPGKGLEWVANI

IGHV3-7

56

P01780
TNGIGRVEGIAVDWI

LRP1

1961

Q07954
QEWRIGGNTIQGVTI

FREM2

1041

Q5SZK8
GQERRVLVNASLGWP

LRP5

491

O75197
IQRPGDLVWINAGTV

KDM6A

1211

O15550
QRPGDLVWINAGTVH

KDM6B

1456

O15054
RVWGVQLQGPSVLES

KIAA1614

71

Q5VZ46
ALAWAQREGQGPAVT

HR

576

O43593
SPGRDINVTGVWERN

PCSK7

161

Q16549
NEGIPWTKVTIRGEN

EXOC2

16

Q96KP1
GVLRQIPVVGSVLNW

PDXDC1

636

Q6P996
QGFIVNGRVWEEPVL

FREM1

1601

Q5H8C1
NAQGQVIGTLPWVVN

POU6F1

11

Q14863
RVVLVNTSLGWPNGL

LRP6

481

O75581
VQGRPQPEVTWRING

L1CAM

356

P32004
AVVQAIVRTAGGWAA

GGTLC2

191

Q14390
LQAVWRGPAGLVTQL

ANKRD65

46

E5RJM6
EAVTRAKQIVWNGPV

PGK1

326

P00558
VAAGIWLVEPGEAAQ

PRR25

326

Q96S07
QGLTENGIPAVVWNI

FAM13A

51

O94988
GVADGLANLNPVTWV

ERVK-7

1376

P63135
RVPVIVQVHGGFSQW

HMCN1

4521

Q96RW7
VRWETQQPECGGILT

CUBN

581

O60494
WVNGQVPDGVSKVLV

APOB

721

P04114
IQWEERNVTAIQGPG

IDH3A

61

P50213
GVADGLANLNPVTWV

ERVK-25

616

P61570
GVADGLANLNPVTWV

ERVK-6

616

Q69384
TPNKGVWVNGLRVDL

FCGBP

5306

Q9Y6R7
IVTITWGGQNIGRSP

FLNA

551

P21333
WTAEGRVVGVTQPRR

DHX35

96

Q9H5Z1
GGAVLQLRPNDQVWV

COL8A2

661

P25067
VQAPLSQQRWVGGSV

BSG

26

P35613
VPQTTQGFIGWRSAV

C20orf85

91

Q9H1P6
GAWRVTLVQQAAAGP

GLI4

141

P10075
VGWQAVATVPEILNG

CNTN6

641

Q9UQ52
AGVIGVELGSVWQRL

DLD

221

P09622
VPVGWQRRVDQNGVL

MBD5

21

Q9P267
QVDVWGAQAGLVVAG

EMC9

66

Q9Y3B6
SQAWREEVAAPGAVG

FAM83H

766

Q6ZRV2
NPAVPWGQGIDIQRA

GRIA1

326

P42261
NGSVPIWITAQRQGL

ENPP7

121

Q6UWV6
WALVQAGIRDGVVRP

FASN

1811

P49327
QWQPVNTGRGIAFSI

CFAP47

886

Q6ZTR5
EVPVTRLQEQGLQGW

CREB3L4

36

Q8TEY5
WQILERTPNGIIVAG

PHKB

946

Q93100
LRQSIVGAEVGVWTG

PRDM4

416

Q9UKN5
VDNRVVGQTGWGQVA

PKN3

336

Q6P5Z2
EAVNGNLVVGTLAWP

SLC12A5

491

Q9H2X9
NVAIWALASVVGVPV

OPRL1

171

P41146
WTPVQVFVLAQGLGV

OPRL1

276

P41146
LVGANGIWGQRAVDI

AGXT

101

P21549
VQLVGQSPGEGRWQE

PUS3

246

Q9BZE2
GDRVGVQPGNSRVWQ

ITPKB

496

P27987
GQIVVQSSAWERPGA

NBEAL2

2611

Q6ZNJ1
EVQRGQFQGRPVSVW

EPPK1

2646

P58107
EVQRGQFQGRPVSVW

EPPK1

3711

P58107
VQRGQFQGRPVSVWD

EPPK1

4246

P58107
TVQVSWLALIQRGGG

RNF128

111

Q8TEB7
EIVQGVLQQGTAWRR

ST8SIA1

56

Q92185
VSILWIPVVQASQGG

SLC5A11

431

Q8WWX8
QNNLPAVRWVGGPEI

CCT5

316

P48643
WGELVQLDPQTVGVI

SUPT5H

536

O00267
WGTTQDGQTRPRVVK

SEC23IP

411

Q9Y6Y8
AVPGQANEIVLIEWG

NPTX2

271

P47972
VGATKVPRNQDWLGV

PMEL

21

P40967
VLPDGQVIWVNNTII

PMEL

96

P40967
VVQVIRQRNWVVVGG

MRPL24

76

Q96A35
EAVQGGWQLLQTRVV

SPTBN5

721

Q9NRC6
LRSIGQAVQPWVEAV

PNMA6A

136

P0CW24
RQTWGAEGRVQGALV

B3GNT9

136

Q6UX72
GVQLTNINVVPFGIW

CMAHP

131

Q9Y471
PGFRITVVTWNVGTA

INPP5J

421

Q15735
AVIQSVPGFWANVIA

TSPY9

156

A0A494C1R9
QLTRVAVDVGAGPWG

SEMA6B

426

Q9H3T3
VVNPWIIIGGVATVV

SEPHS2

216

Q99611
AVIQSVPGFWANVIA

TSPY4

156

P0CV99
LVVEGGPNVILSVWE

TRPM6

291

Q9BX84
VSVAWLPVVQAAQGG

SLC5A2

436

P31639
EAWLLPAVGREVAQG

SARM1

101

Q6SZW1
PAAGNTWRTVADGVQ

ROBO3

596

Q96MS0
PWRGQQGLAEVAVRL

ROBO3

661

Q96MS0
LQVIKGNGRTSPWEI

RNF25

31

Q96BH1
PAVSAVWGQCQVRIR

SPSB2

201

Q99619
AETRQPVVILLGWGG

TMEM53

31

Q6P2H8
WIRGSNPQDKRQVGI

MYCBPAP

416

Q8TBZ2
DSIQVGGRISPQTVW

PHF3

1241

Q92576
RNGVLWAQGPLETVT

SIGLEC1

746

Q9BZZ2
AVNVQVWPGATVREG

SIGLEC1

1086

Q9BZZ2
VWPGATVREGQLVNL

SIGLEC1

1091

Q9BZZ2
PWLPVNVTQGGARQE

SEMA5B

781

Q9P283
RQGSQGWEVLDPAVA

IGSF9

661

Q9P2J2
VATVEAVQGRPGGTW

ZNF469

1616

Q96JG9
GVSVGQRWQDVLPVA

TTC38

306

Q5R3I4
VAGALVVALWGPLQD

TSPAN10

166

Q9H1Z9
AEAVQLQRVVGPDWT

ZDHHC19

261

Q8WVZ1
WVGDVVVPCTQASQR

SNAPC4

751

Q5SXM2
ATQQWLGGQRGVRVP

SNAPC4

1281

Q5SXM2
GTTQIDPNWVIRHQG

THBS2

971

P35442
NGVVVTWNLGRPSRN

WDR24

96

Q96S15
VNRVPAGNWVLIEGV

EFTUD2

541

Q15029
RGETRQWQTAVIIGP

ZNF711

361

Q9Y462
TVLPGELQSWVRGQR

ZNF202

96

O95125
WRGNGTNVIKIAPET

SLC25A24

251

Q6NUK1
TIGIAPWGVIENRND

TRPM7

201

Q96QT4
QVTQAPGGWEVLAVV

TYRO3

261

Q06418
TQGWAEILVRRPTGN

TSC2

1191

P49815
GNDWVPVTIIDVRGH

N4BP2L2

51

Q92802
PGGPRRWVTVQVQGQ

MZF1

126

P28698