Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ATPase_dyneun-rel_AAA	DNAH3 MDN1 DYNC2H1	6.84e-06	14	51	3	IPR011704
Domain	AAA_5	DNAH3 MDN1 DYNC2H1	6.84e-06	14	51	3	PF07728
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DYNC2H1	6.51e-04	14	51	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DYNC2H1	6.51e-04	14	51	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DYNC2H1	6.51e-04	14	51	2	IPR013602
Domain	DHC_N2	DNAH3 DYNC2H1	6.51e-04	14	51	2	PF08393
Domain	MT	DNAH3 DYNC2H1	6.51e-04	14	51	2	PF12777
Domain	AAA_8	DNAH3 DYNC2H1	6.51e-04	14	51	2	PF12780
Domain	DHC_fam	DNAH3 DYNC2H1	7.50e-04	15	51	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DYNC2H1	7.50e-04	15	51	2	IPR004273
Domain	Dynein_heavy	DNAH3 DYNC2H1	7.50e-04	15	51	2	PF03028
Domain	H2B	H2BC20P H2BC19P	1.49e-03	21	51	2	SM00427
Domain	HISTONE_H2B	H2BC20P H2BC19P	1.49e-03	21	51	2	PS00357
Domain	Histone_H2B	H2BC20P H2BC19P	1.49e-03	21	51	2	IPR000558
Domain	AAA+_ATPase	DNAH3 MDN1 DYNC2H1	7.13e-03	144	51	3	IPR003593
Domain	AAA	DNAH3 MDN1 DYNC2H1	7.13e-03	144	51	3	SM00382
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	RAE1 KMT2A TNPO3	3.00e-05	40	52	3	37516964
Pubmed	Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line.	H2BC20P H2BC19P	3.28e-05	6	52	2	20194426
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NAA25 PPP2R5E RAE1 DYNC2H1 UBAC2 VPS53 TNPO3 CLCC1	7.36e-05	942	52	8	31073040
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SCML2 RAE1 DYNC2H1 PAN2 PYGL KLHL8 TNPO3 NDUFS1	1.15e-04	1005	52	8	19615732
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	MDN1 TMEM126B MASTL BIRC6 VPS53 NDUFS1	1.17e-04	515	52	6	31617661
Pubmed	Functional characterization of a human histone gene cluster duplication.	H2BC20P H2BC19P	1.20e-04	11	52	2	15527963
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	PPP2R5E DYNC2H1 PAN2 PYGL UBAC2 PCARE VPS53 TNPO3 NDUFS1	1.35e-04	1321	52	9	27173435
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	PIAS4 NAA25 SCML2 MDN1 KMT2A TNPO3	1.41e-04	533	52	6	30554943
Pubmed	Genome-wide association study of height and body mass index in Australian twin families.	FTO ADAMTSL3	1.43e-04	12	52	2	20397748
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH3 DYNC2H1	1.97e-04	14	52	2	9373155
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP31 PAN2 FREM1	2.48e-04	81	52	3	12838346
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	GSTM3 USP31 MOSPD2 MDN1 DYNC2H1 TMEM126B SUCO NDUFS1 CLCC1	3.25e-04	1487	52	9	33957083
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	GSTM3 PIAS4 MDN1 MASTL TNPO3	3.27e-04	400	52	5	35013556
Pubmed	Inhibition of core histones acetylation by carcinogenic nickel(II).	H2BC20P H2BC19P	3.30e-04	18	52	2	16283522
Pubmed	Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.	H2BC20P H2BC19P	3.30e-04	18	52	2	12757711
Pubmed	Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.	GSTM3 GOT1L1 NDUFS1	4.21e-04	97	52	3	22360420
Pubmed	Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.	DYNC2H1 PLD5	4.52e-04	21	52	2	24057671
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	SCML2 MDN1	4.52e-04	21	52	2	37014752
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP31 ADAMTSL3 BIRC6	5.02e-04	103	52	3	10574462
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	MDN1 DOCK8 PYGL BIRC6	5.14e-04	247	52	4	32989298
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP31 PAN2	5.44e-04	23	52	2	14715245
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	INSR FTO	6.43e-04	25	52	2	35874829
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	GSTM3 MDN1 RAE1 KMT2A PYGL H2BC20P TNPO3 NDUFS1	7.11e-04	1318	52	8	30463901
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	PIAS4 PPP2R5E RAE1 INSR KMT2A KLHL8	7.50e-04	730	52	6	34857952
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SCML2 MOSPD2 MASTL BIRC6 NDUFS1 CLCC1	7.67e-04	733	52	6	34672954
Pubmed	Maternal DNA Methylation Regulates Early Trophoblast Development.	SCML2 PLCB4	8.08e-04	28	52	2	26812015
Pubmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin.	PIK3CD KMT2A	8.08e-04	28	52	2	27256596
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	TMIGD1 PPP2R5E UBAC2	8.81e-04	125	52	3	17062627
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	MOSPD2 UBAC2 NDUFS1 CLCC1	1.05e-03	299	52	4	37931956
Pubmed	DHHC protein family targets different subsets of glioma stem cells in specific niches.	PIK3CD INSR	1.12e-03	33	52	2	30658672
Pubmed	Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.	NAA25 FTO	1.12e-03	33	52	2	20203524
Pubmed	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	GSTM3 KMT2A BIRC6	1.22e-03	140	52	3	20819778
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	RAE1 PYGL BIRC6 NDUFS1	1.24e-03	313	52	4	16196087
Pubmed	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	PIK3CD CCR9 PLCB4	1.25e-03	141	52	3	20056178
Cytoband	1q24	ADCY10 SUCO	2.36e-04	20	52	2	1q24
GeneFamily	Rhomboid family	RHBDL3 UBAC2	4.71e-04	14	42	2	926
Coexpression	GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN	PIAS4 TMIGD1 MOSPD2 PYGL TNPO3	9.57e-06	149	50	5	M6683
Disease	abdominal adipose tissue measurement	FTO ADAMTSL3 VPS53	1.14e-04	53	52	3	EFO_0803316
Disease	chronotype measurement	USP31 NAA25 INSR RHBDL3 PLCB4 FTO BIRC6 NDUFS1	1.45e-04	882	52	8	EFO_0008328
Disease	age at menopause	H2BC20P H2BC19P FTO BIRC6 TNPO3	1.90e-04	302	52	5	EFO_0004704
Disease	Ischemic stroke	PPP2R5E TMEM126B OR4E1 PLCB4 ADAMTSL3	2.64e-04	324	52	5	HP_0002140
Disease	developmental dysplasia of the hip	ADAMTSL3 VPS53	3.60e-04	16	52	2	EFO_1000648
Disease	Congenital hernia of foramen of Morgagni	INSR FREM1	5.11e-04	19	52	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	INSR FREM1	5.11e-04	19	52	2	C0265700
Disease	Congenital diaphragmatic hernia	INSR FREM1	6.26e-04	21	52	2	C0235833
Disease	uric acid measurement	DNAH3 NAA25 DYNC2H1 INSR FTO BIRC6	6.92e-04	610	52	6	EFO_0004761
Disease	mean arterial pressure, alcohol drinking	NAA25 INSR FTO	6.98e-04	98	52	3	EFO_0004329, EFO_0006340
Disease	body fat percentage, coronary artery disease	DYNC2H1 FTO	8.20e-04	24	52	2	EFO_0001645, EFO_0007800
Disease	cerebral white matter volume change measurement, age at assessment	KMT2A FREM1	1.12e-03	28	52	2	EFO_0008007, EFO_0021499
Disease	glucose metabolism disease (implicated_via_orthology)	PIK3CD INSR	1.12e-03	28	52	2	DOID:4194 (implicated_via_orthology)
Disease	MITOCHONDRIAL COMPLEX I DEFICIENCY	TMEM126B NDUFS1	1.28e-03	30	52	2	C1838979
Disease	systolic blood pressure, alcohol drinking	NAA25 INSR FTO	1.51e-03	128	52	3	EFO_0004329, EFO_0006335
Disease	carbohydrate intake measurement	NAA25 FTO	1.65e-03	34	52	2	EFO_0010811
Disease	energy intake	NAA25 PYGL FTO	1.72e-03	134	52	3	EFO_0003939

Protein segments in the cluster

Peptide	Gene	Start	Entry
LMKFWPKTCSQKEVM	PPP2R5E	306	Q16537
FNWSMSLPCNMVLKK	BIRC6	3526	Q9NR09
TKMSMAAKNLWLPDI	HTR3E	111	A5X5Y0
WAKLMSMIKSKQIFP	GOT1L1	196	Q8NHS2
PTMMSWNAVEKLCAK	MASTL	336	Q96GX5
FEILPCWNMKMMIKT	ADCY10	846	Q96PN6
KTLKFWDTRSSNPMM	RAE1	151	P78406
KMTSFTNLKMWIQEC	RAB33A	121	Q14088
NVWLPFSIRMKMTKN	PAN2	806	Q504Q3
LQKMWESQDFLKCMQ	C20orf96	286	Q9NUD7
FQPLESIMKCVQMSW	MDN1	2046	Q9NU22
SCKWRMNKILGFTMF	SLC24A1	1061	O60721
WCKAMGIMNSFLNDI	H2BC20P	56	Q6DN03
WCKAMGIMNSFLNDI	H2BC19P	56	Q6DRA6
CAGMMIWNFVKEKNF	GPR155	426	Q7Z3F1
WCQPMAQLEALWKKM	FTO	396	Q9C0B1
FDPLTNKWMMKASMN	KLHL8	386	Q9P2G9
MNPKICGLMATFSWI	OR2M2	136	Q96R28
MNPKLCVFMTVASWT	OR2M4	136	Q96R27
KLIQFDPGMSTKMWN	FREM1	1796	Q5H8C1
QFCKMPINNKMAQWG	GSTM3	206	P21266
MCWQFNPKMRPTFLE	INSR	1271	P06213
SCALNMWLAKSVPVM	THAP12	361	O43422
WSNSSMKKIPEMLFS	DYNC2H1	2811	Q8NCM8
LMICFLWIMKNADQS	DOCK8	1296	Q8NF50
VFFQSCAKAVMWQKM	DNAH3	3656	Q8TD57
QWKFQTFMCKVVNSM	CCR9	111	P51686
MTLQCTKSAGPWKMV	CRYBA4	1	P53673
MRKCQNLQWMPSKAY	KMT2A	1191	Q03164
KMSSMSLCAWQEKTP	PCARE	496	A6NGG8
SITLLPMSNNVKMKW	MT-ND2	301	P03891
DMPWLMNAAFKIVKT	MOSPD2	186	Q8NHP6
WMKLAFMTNTNGKIP	PLCB4	151	Q15147
SLFQGWMNLLNMAKK	PLD5	131	Q8N7P1
WMTLCQTQMKLMAIP	TMEM126B	186	Q8IUX1
ACAMPVMKGWNILTN	NDUFS1	91	P28331
NIVMNWSGMKCQFKL	RHBDL3	291	P58872
KSLQMCKWAMNISEA	ST8SIA5	86	O15466
KMEPLNNVCAKKMDW	CLCC1	246	Q96S66
LVCNVKANPQAQMMW	TMIGD1	141	Q6UXZ0
CKPLQYMIVMNWKVC	OR4E1	131	P0C645
MNTSSWPMFLLKTLN	SCML2	136	Q9UQR0
VEQCTFMDSKMKPLW	PIK3CD	746	O00329
NMDLYMLNPCSTKIW	SUCO	336	Q9UBS9
AACDPALTAMSKMQW	VPS53	611	Q5VIR6
VFYLQMNEKKPTWMC	PIAS4	351	Q8N2W9
KMLMKVFRCLGSWFN	TNPO3	196	Q9Y5L0
FCLDWMTMPASKKST	ZNF454	81	Q8N9F8
KMFQVHQVLCIPSWM	UBAC2	196	Q8NBM4
NCMRPSWSLSAKLQM	USP31	861	Q70CQ4
LYMNPKAWNTMVLKN	PYGL	791	P06737
MQTCNLFDCPKWIAM	ADAMTSL3	471	P82987
MAMYKKLSRWPECNA	NAA25	236	Q14CX7