Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	6.19e-06	9	88	3	GO:0160063
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO2 NOMO3 NOMO1	6.36e-06	9	90	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO2 NOMO3 NOMO1	2.71e-05	14	90	3	GO:0072379
Domain	DUF2012	NOMO2 NOMO3 NOMO1	3.76e-07	4	86	3	PF09430
Domain	DUF2012	NOMO2 NOMO3 NOMO1	3.76e-07	4	86	3	IPR019008
Domain	ARM-type_fold	ELMO3 DOCK9 APC2 MROH7 APC ARFGEF2 LTA4H SERAC1 PRKDC HEATR5B	3.55e-06	339	86	10	IPR016024
Domain	Carb-bd-like_fold	NOMO2 NOMO3 NOMO1	5.19e-06	8	86	3	IPR013784
Domain	APC_dom	APC2 APC	2.10e-05	2	86	2	IPR026831
Domain	APC_N	APC2 APC	2.10e-05	2	86	2	IPR032038
Domain	APC_basic_dom	APC2 APC	2.10e-05	2	86	2	IPR009234
Domain	Apc_fam	APC2 APC	2.10e-05	2	86	2	IPR026818
Domain	BMP3/BMP3B	BMP3 GDF10	2.10e-05	2	86	2	IPR017197
Domain	APC_r	APC2 APC	2.10e-05	2	86	2	PF05923
Domain	SAMP	APC2 APC	2.10e-05	2	86	2	PF05924
Domain	APC_rpt	APC2 APC	2.10e-05	2	86	2	IPR009223
Domain	SAMP	APC2 APC	2.10e-05	2	86	2	IPR009224
Domain	APC_basic	APC2 APC	2.10e-05	2	86	2	PF05956
Domain	APC_N_CC	APC2 APC	2.10e-05	2	86	2	PF16689
Domain	CarboxyPept_regulatory_dom	NOMO2 NOMO3 NOMO1	2.61e-05	13	86	3	IPR014766
Domain	-	NOMO2 NOMO3 NOMO1	2.61e-05	13	86	3	2.60.40.1120
Domain	ARM-like	ELMO3 APC2 MROH7 APC ARFGEF2 SERAC1 PRKDC HEATR5B	3.44e-05	270	86	8	IPR011989
Domain	CarboxyPept-like_regulatory	NOMO2 NOMO3 NOMO1	6.12e-05	17	86	3	IPR008969
Domain	-	APC2 MROH7 APC ARFGEF2 SERAC1 PRKDC HEATR5B	7.39e-05	222	86	7	1.25.10.10
Domain	-	ATP8B4 ATP12A ATP2B2	4.25e-04	32	86	3	3.40.1110.10
Domain	-	ATP8B4 ATP12A ATP2B2	4.25e-04	32	86	3	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP8B4 ATP12A ATP2B2	5.55e-04	35	86	3	IPR023299
Domain	P_typ_ATPase	ATP8B4 ATP12A ATP2B2	6.03e-04	36	86	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP8B4 ATP12A ATP2B2	6.03e-04	36	86	3	IPR018303
Domain	ATPASE_E1_E2	ATP8B4 ATP12A ATP2B2	6.03e-04	36	86	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8B4 ATP12A ATP2B2	6.54e-04	37	86	3	IPR008250
Domain	E1-E2_ATPase	ATP8B4 ATP12A ATP2B2	6.54e-04	37	86	3	PF00122
Domain	Hydrolase_3	ATP8B4 ATP2B2	9.21e-04	10	86	2	PF08282
Domain	SIAH-type	TRAF4 ST18	2.41e-03	16	86	2	IPR013323
Domain	-	ATP12A ATP2B2	2.41e-03	16	86	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP12A ATP2B2	2.41e-03	16	86	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP12A ATP2B2	2.72e-03	17	86	2	IPR006068
Domain	Cation_ATPase_C	ATP12A ATP2B2	2.72e-03	17	86	2	PF00689
Domain	Cation_ATPase_N	ATP12A ATP2B2	3.06e-03	18	86	2	PF00690
Domain	Cation_ATPase_N	ATP12A ATP2B2	3.06e-03	18	86	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP12A ATP2B2	3.41e-03	19	86	2	IPR004014
Domain	HEAT_REPEAT	MROH7 PRKDC HEATR5B	4.13e-03	70	86	3	PS50077
Domain	HAD-like_dom	ATP8B4 ATP12A ATP2B2	5.79e-03	79	86	3	IPR023214
Domain	TGFb_propeptide	BMP3 GDF10	7.33e-03	28	86	2	PF00688
Domain	TGF-b_N	BMP3 GDF10	7.33e-03	28	86	2	IPR001111
Domain	Arm	APC2 APC	8.94e-03	31	86	2	PF00514
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO2 NOMO3 NOMO1	1.73e-08	3	91	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO2 NOMO3 NOMO1	1.73e-08	3	91	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO2 NOMO3 NOMO1	6.92e-08	4	91	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO2 NOMO3 NOMO1	6.92e-08	4	91	3	9267806
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO2 NOMO3 NOMO1	9.61e-07	8	91	3	15257293
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO2 NOMO3 NOMO1	1.44e-06	9	91	3	36261522
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO2 NOMO3 NOMO1	2.82e-06	11	91	3	32820719
Pubmed	Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.	APC2 APC	6.77e-06	2	91	2	27694902
Pubmed	Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation.	APC PRKDC	6.77e-06	2	91	2	8567125
Pubmed	APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.	APC2 APC	6.77e-06	2	91	2	31291912
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	NOMO2 SBF2 ATP12A NOMO3 NOMO1	1.08e-05	110	91	5	27889896
Pubmed	Defining the membrane proteome of NK cells.	TRAP1 CTSC DOCK9 GYS1 CYP20A1 HELZ2 ARFGEF2 PAM RECQL PRKDC HEATR5B ARCN1 NOMO1	1.09e-05	1168	91	13	19946888
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	MYH8 APC HEATR5B	1.91e-05	20	91	3	21689717
Pubmed	Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.	APC PRKDC	2.03e-05	3	91	2	19194513
Pubmed	TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.	TET1 APC	2.03e-05	3	91	2	36764492
Pubmed	The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.	GTF2H2 ERCC6	2.03e-05	3	91	2	7664335
Pubmed	Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c.	APC PRKDC	2.03e-05	3	91	2	12750251
Pubmed	Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.	MYO7A SULF1	2.03e-05	3	91	2	25370455
Pubmed	MicroRNA-191 regulates endometrial cancer cell growth via TET1-mediated epigenetic modulation of APC.	TET1 APC	2.03e-05	3	91	2	32003827
Pubmed	Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.	APC2 APC	2.03e-05	3	91	2	23840886
Pubmed	Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.	APC PRKDC	4.05e-05	4	91	2	35537038
Pubmed	The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping.	CYP2F1 ATP2B2	4.05e-05	4	91	2	1974816
Pubmed	A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.	APC2 APC	4.05e-05	4	91	2	26393419
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	NOMO2 SPIN1 ARFGEF2 NOMO3 NOMO1	5.80e-05	156	91	5	30409884
Pubmed	Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.	APC PRKDC	6.74e-05	5	91	2	26107252
Pubmed	Genetics of vestibular disorders: pathophysiological insights.	MYO7A FAM136A	6.74e-05	5	91	2	27083884
Pubmed	Two-factor authentication underpins the precision of the piRNA pathway.	SPIN1 SPOCD1	6.74e-05	5	91	2	39294378
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	NOMO2 NOMO3 NOMO1	7.39e-05	31	91	3	19136429
Pubmed	Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.	ZBTB38 CYP20A1 LTA4H	8.93e-05	33	91	3	20966902
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NOMO2 NOMO3 NOMO1	8.93e-05	33	91	3	30783098
Pubmed	The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.	APC2 APC	1.01e-04	6	91	2	10074433
Pubmed	Genomics and hearing impairment.	MYO7A ATP2B2	1.01e-04	6	91	2	9927480
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	TRAP1 UXS1 SLC30A5 NOMO2 CTSC ACP1 CYP20A1 XXYLT1 PAM ARCN1 NOMO3 NOMO1 VCPIP1	1.02e-04	1451	91	13	30550785
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	DNAH3 NOMO2 NOMO3 NOMO1	1.03e-04	92	91	4	10493829
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZBTB38 NOMO2 SULF1 ATRNL1 APC2 APBA1 APC ARFGEF2 PRKDC ST18 ARCN1 VCPIP1	1.31e-04	1285	91	12	35914814
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DNAH3 OTC MYO7A EXOC3L4 XXYLT1 LTA4H PRKDC QRICH2 ARCN1	1.35e-04	736	91	9	29676528
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	DLGAP2 TSHZ3 ZMYND11 USF3 APC2 WDR90 CCDC141	1.39e-04	430	91	7	35044719
Pubmed	Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.	APC2 APC	1.41e-04	7	91	2	10330403
Pubmed	DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.	DLGAP2 APC	1.41e-04	7	91	2	9286858
Pubmed	DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.	APC PRKDC	1.41e-04	7	91	2	29431745
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	TSHZ3 BBX FAM136A SULF1 SPIN1 CTSC QRICH2 ZNF786 VCPIP1	1.56e-04	750	91	9	11230166
Pubmed	Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.	ZNF536 ST18 ADARB2	1.60e-04	40	91	3	27657450
Pubmed	Proteome-wide analysis of phospho-regulated PDZ domain interactions.	APC HEATR5B ATP2B2	1.85e-04	42	91	3	30126976
Pubmed	Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.	GTF2H2 ERCC6	1.88e-04	8	91	2	8652557
Pubmed	Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.	MYH8 NEB	1.88e-04	8	91	2	1618148
Pubmed	Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.	APC PRKDC	1.88e-04	8	91	2	27989802
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	TRAP1 PRKDC ARCN1 NOMO1	2.27e-04	113	91	4	30352685
Pubmed	A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.	APC PRKDC	2.41e-04	9	91	2	25362351
Pubmed	Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.	APC2 APC	2.41e-04	9	91	2	9601641
Pubmed	Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.	MYO7A ATP2B2	2.41e-04	9	91	2	19339464
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	NOMO2 CTSC HELZ2 PRKDC NOMO3 NOMO1	2.95e-04	344	91	6	30333137
Pubmed	Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.	FAM136A APC	3.01e-04	10	91	2	19515974
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ROCK2 UXS1 NOMO2 CTSC ACP1 XXYLT1 FSTL4 ARFGEF2 PAM RECQL NOMO1	3.01e-04	1201	91	11	35696571
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	MYO7A DOCK9 APBA1 ATP2B2	3.65e-04	128	91	4	30995482
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	GTF2H2 BBX MYO7A TET1 CYP20A1 XXYLT1 MROH7 TRAPPC10 ST18 ATP2B2 VWA5B1	4.00e-04	1242	91	11	30973865
Pubmed	Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.	MED24 HELZ2	4.39e-04	12	91	2	12189208
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MED24 FMN1 SPIN1 ATRNL1 DOCK9 EXOC3L4 SBF2 TET1 APC TRAPPC10	5.44e-04	1084	91	10	11544199
Pubmed	Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.	NOMO2 NOMO3 NOMO1	6.14e-04	63	91	3	31266804
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	APC2 APC	6.95e-04	15	91	2	16510875
Pubmed	TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.	MYH8 SPIN1 CTSC	7.35e-04	67	91	3	34644545
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	TRAP1 PRKDC NOMO3	7.35e-04	67	91	3	21875946
Pubmed	Modifier genes and protective alleles in humans and mice.	APC ATP2B2	7.93e-04	16	91	2	12787792
Pubmed	Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain.	TET1 APC	7.93e-04	16	91	2	34429415
Pubmed	Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.	APC PRKDC	7.93e-04	16	91	2	32730753
Pubmed	Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.	GTF2H2 ERCC6	7.93e-04	16	91	2	11313499
Pubmed	Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium.	MYH8 NEB	8.98e-04	17	91	2	34622152
Pubmed	Functional proteomics mapping of a human signaling pathway.	TRAF4 ZMYND11 ERCC6 ARFGEF2 NOMO3 NOMO1 VCPIP1	9.33e-04	591	91	7	15231748
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DLGAP2 APC2 APC TRAPPC10 PAM SERAC1	9.49e-04	430	91	6	32581705
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ROCK2 MED24 HELZ2 ARFGEF2 TRAPPC10 PRKDC INTS3 VCPIP1	9.72e-04	774	91	8	15302935
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	BBX SLC30A5 CDC42EP4 CCDC146 APC ARFGEF2 PRKDC ARCN1	9.97e-04	777	91	8	35844135
Pubmed	Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.	MYO7A FMN1	1.01e-03	18	91	2	30833597
Pubmed	Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.	GTF2H2 ERCC6 CYP2F1	1.06e-03	76	91	3	22323595
Pubmed	AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.	FAM136A NEB VCPIP1	1.06e-03	76	91	3	29599191
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	TRAP1 NOMO2 MTHFD2 TBC1D7 ARCN1 NOMO3 NOMO1	1.08e-03	606	91	7	36538041
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	FMN1 APC PRKDC	1.10e-03	77	91	3	24927568
Pubmed	A quantitative survey of gravity receptor function in mutant mouse strains.	MYO7A ATP2B2	1.25e-03	20	91	2	16235133
Pubmed	Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.	APC2 APC	1.25e-03	20	91	2	25535916
Pubmed	TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.	TSHZ3 GDF10	1.38e-03	21	91	2	27668656
Pubmed	Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution.	MYH8 FSTL4	1.51e-03	22	91	2	37468485
Pubmed	Tbx2 is a master regulator of inner versus outer hair cell differentiation.	MYO7A ATP2B2	1.65e-03	23	91	2	35508658
Pubmed	Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.	BMP3 SULF1 GDF10	1.73e-03	90	91	3	30228991
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	NOMO2 NOMO3 NOMO1	1.73e-03	90	91	3	15616553
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ROCK2 USF3 ATP8B4 ATRNL1 SBF2 HELZ2	1.90e-03	493	91	6	15368895
Pubmed	Decidualisation and placentation defects are a major cause of age-related reproductive decline.	TET1 GDF10	1.95e-03	25	91	2	28874785
Pubmed	Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.	CYP2F1 APC	1.95e-03	25	91	2	23562608
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CDC42EP4 STXBP5L DOCK9 APC ATP2B2	2.22e-03	347	91	5	17114649
Pubmed	A protein interaction framework for human mRNA degradation.	NOMO2 FAM136A CTSC NOMO3 NOMO1	2.22e-03	347	91	5	15231747
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	TRAP1 ERCC6 MYO7A APC2 PRKDC NEB	2.32e-03	513	91	6	25798074
Pubmed	The protein interaction landscape of the human CMGC kinase group.	MED24 ZMYND11 GTF2H2 CDC42EP4 HIPK4 APC NEB	2.35e-03	695	91	7	23602568
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRAF4 MYO7A DOCK9 SBF2 HELZ2 XXYLT1 ARFGEF2 WDR90 PRKDC	2.44e-03	1105	91	9	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SBF2 TET1 HELZ2	2.47e-03	102	91	3	11214970
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SULF1 DOCK9 FSTL4	2.61e-03	104	91	3	10470851
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	BMP3 ZNF536 ATRNL1 FSTL4 ADARB2 QRICH2	1.03e-06	164	90	6	4d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ROCK2 DLGAP2 STXBP5L ATRNL1 PAM ATP2B2	3.08e-06	198	90	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	BMP3 TSHZ3 ZNF536 ATRNL1 PAM ADARB2	3.27e-06	200	90	6	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP3 ZNF536 ATP12A GDF10 ADARB2	2.01e-05	163	90	5	bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell	Frontal_cortex\|World / BrainAtlas - Mouse McCarroll V32	ROCK2 BMP3 DLGAP2 TSHZ3 ATP12A	2.07e-05	164	90	5	e09291711abf8680e78170328313719092b0142f
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D122\|Adult / Lineage, Cell type, age group and donor	TSHZ3 ATP8B4 MYO7A FMN1 APBA1	2.20e-05	166	90	5	be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP2 HIPK4 ATRNL1 FSTL4 ATP2B2	3.07e-05	178	90	5	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP2 HIPK4 ATRNL1 FSTL4 ATP2B2	3.07e-05	178	90	5	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	TSHZ3 ATP8B4 MYO7A FMN1 APBA1	3.69e-05	185	90	5	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TSHZ3 ATP8B4 FMN1 CTSC APBA1	3.69e-05	185	90	5	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 STXBP5L FMN1 ATRNL1 FSTL4	3.88e-05	187	90	5	f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 STXBP5L FMN1 ATRNL1 FSTL4	4.08e-05	189	90	5	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	HSPCs-Gran/Mono_prog.\|World / Lineage and Cell class	TRAP1 ATP8B4 FAM136A CTSC LTA4H	4.19e-05	190	90	5	94547c1cc2c3f2ac28a6d07317e50e1e3fd20267
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USF3 ZNF253 SBF2 TRAPPC10 PRKDC	4.51e-05	193	90	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TSHZ3 SULF1 CTSC APBA1 GDF10	4.62e-05	194	90	5	5f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ATP8B4 MYO7A FMN1 CTSC CCDC141	4.74e-05	195	90	5	4008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCell	IPF-Myeloid\|IPF / Disease state, Lineage and Cell class	FMN1 CTSC SBF2 LTA4H UPP1	4.74e-05	195	90	5	fdeb958aeaa00f3fc25c4e59efbbc6f4a572c9ce
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP5L FMN1 FSTL4 PAM ATP2B2	4.74e-05	195	90	5	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 STXBP5L ATRNL1 PAM ATP2B2	5.09e-05	198	90	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 GDF10 ST18 ADARB2 VWA5B1	5.34e-05	200	90	5	501a3b93624df463458a35d3e6648d4ccc941724
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 GDF10 ST18 ADARB2 VWA5B1	5.34e-05	200	90	5	d1f36a8232411933b1494168ec912fd0e5246428
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm\|5w / Sample Type, Dataset, Time_group, and Cell type.	ERCC6 MYO7A STXBP5L HELZ2 ARFGEF2	5.34e-05	200	90	5	0927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	BMP3 MYH8 ELMO3 FMN1	7.35e-05	110	90	4	5496c92932195386025254b9129d69b12c8e3340
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)--\|Striatum / BrainAtlas - Mouse McCarroll V32	BMP3 MYH8 ELMO3 FMN1	7.35e-05	110	90	4	41306a2d4a5a39569437eb123e47f98ef8afab24
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)\|Striatum / BrainAtlas - Mouse McCarroll V32	BMP3 MYH8 ELMO3 FMN1	7.35e-05	110	90	4	1fe08060248b25329f73b80d74435c108bee1359
Disease	familial adenomatous polyposis 1 (implicated_via_orthology)	APC2 APC	8.79e-06	2	88	2	DOID:0080409 (implicated_via_orthology)
Disease	colorectal cancer, inflammatory bowel disease	BMP3 DLGAP2 ATP8B4	2.40e-05	19	88	3	EFO_0003767, MONDO_0005575
Disease	Moyamoya disease	DOCK9 SBF2 FSTL4	2.34e-04	40	88	3	MONDO_0016820
Disease	infant head circumference	ZBTB38 ARFGEF2	9.00e-04	15	88	2	EFO_0004577
Disease	anemia (implicated_via_orthology)	APC SLC4A9	9.00e-04	15	88	2	DOID:2355 (implicated_via_orthology)
Disease	nucleotide measurement	ATP8B4 BBX SULF1	1.37e-03	73	88	3	EFO_0010513
Disease	Corneal astigmatism	BMP3 TSHZ3 DOCK9	1.60e-03	77	88	3	EFO_1002040
Disease	feeling miserable measurement	MED24 DLGAP2 BBX	1.72e-03	79	88	3	EFO_0009598
Disease	daytime rest measurement	DLGAP2 ZNF556 HELZ2 APC PAM	1.92e-03	295	88	5	EFO_0007828
Disease	paracentral lobule volume measurement	STXBP5L DOCK9	2.52e-03	25	88	2	EFO_0010317
Disease	proline measurement	TBC1D7 NOBOX	2.73e-03	26	88	2	EFO_0009773
Disease	psychosis predisposition measurement	CCDC141 VWA5B1	2.73e-03	26	88	2	EFO_0008337

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSHLTDKLMMDGHEV	UXS1	101	Q8NBZ7
PLSMDVHMLVAEHVK	EXOC3L4	421	Q17RC7
MGEMPSITLSTHLHH	SLC4A9	86	Q96Q91
GHLSVDMAKSHRDIM	BMP3	181	P12645
KDHMCHPHGIMIIED	BBX	426	Q8WY36
AVSMDELASPHHPRM	ARFGEF2	1096	Q9Y6D5
DFKPRASMDTVHHML	PAM	91	P19021
HSECVMMPVVLGDHV	DLGAP2	141	Q9P1A6
HHLMESIKMGDPKVH	ATP8B4	451	Q8TF62
GVHSVMKHDAIMDGA	ERCC6	1261	Q03468
SVDKDPMLLSGTHVM	ATP2B2	251	Q01814
RMAEGLSHHDPIMKV	MROH7	1006	Q68CQ1
HHVLGTITTDKMMDV	NOMO3	666	P69849
SSTLLSMSMAPHKAH	QRICH2	1186	Q9H0J4
TPMHARHKALAGIVM	ADARB2	381	Q9NS39
KEDPLSHFHMDTLLM	CYP2F1	276	P24903
DHKDIHAALQPMEGM	FMN1	846	Q68DA7
AILVMHHSMKPHPAI	INTS3	416	Q68E01
MPLLMDVAGSDSSHK	NOBOX	466	O60393
EHKASMHPVTAMLVG	LTA4H	591	P09960
HCALPTEAQHMVGAM	FAM189A1	501	O60320
HHVLGTITTDKMMDV	NOMO2	666	Q5JPE7
SDMMVPLKAAITGHH	HIPK4	451	Q8NE63
HIKSLHCMIPGIVAM	SBF2	836	Q86WG5
HCMIPGIVAMHIETL	SBF2	841	Q86WG5
HGITVLPKMGSHEPM	AQP7P3	296	A6NL99
HGITVLPKMGSHEPM	AQP7B	301	A0A075B734
SIHEMDDPHGKRFLM	ATP12A	506	P54707
TLGPSAQDMVAVHMH	GDF10	66	P55107
EDMAMMTHLHEPGVL	MYH8	91	P13535
PMVGVSMTHRFAKHA	OR51Q1	256	Q8NH59
LHSIMMSAAKFGMHL	OTC	201	P00480
HHVLGTITTDKMMDV	NOMO1	666	Q15155
VHSKHKMIAMGSAAA	APC2	676	O95996
TMMSHIPSVMKAHGA	HEATR5B	646	Q9P2D3
ALHRISAEHPESMMS	CCDC141	1311	Q6ZP82
LHAMEGHVMIAFLPT	DOCK9	856	Q9BZ29
PSMHAAATAMAELKG	DNAH3	556	Q8TD57
LETMMPLKTIGLHHH	FSTL4	626	Q6MZW2
MISAPLGDFRHTMHV	CDC42EP4	26	Q9H3Q1
NEALMKLELVHHGPM	CTSC	356	P53634
HILSNAVGEIHMKTM	APBA1	806	Q02410
SSRGPMKLIGMHHSE	ATRNL1	976	Q5VV63
MHHSEMVLDTNLCPK	ATRNL1	986	Q5VV63
NIIHSAAPMGDEMAH	ELMO3	266	Q96BJ8
MDRHHGTPMLLDGVK	C20orf27	141	Q9GZN8
LPGHLDAKHHKAMME	IZUMO1	41	Q8IYV9
VTKCVDDHMHLIPTM	FAM136A	111	Q96C01
HVPLSQHMLGFAMKS	CYP20A1	161	Q6UW02
VHLFVHHMGMEKVPE	HELZ2	2066	Q9BYK8
MSARHMALSKAFPEH	GYS1	606	P13807
LTPMKHMLAASAGEV	SLC25A26	86	Q70HW3
ATKMHAPPINMESVH	ARCN1	261	P48444
DPSMEAHMGAIKAIS	TAS2R39	251	P59534
VSHGMGIPSISIMLH	UPP1	106	Q16831
EAMKSPHIMESSHAA	SERAC1	346	Q96JX3
GMPIAMLLHTDGAHE	MTHFD2	206	P13995
TVEEMMPHIQHLKGA	PRORSD1P	31	A6NEY8
PTMLSVHAEQMHKTG	MED24	226	O75448
QSCMKRHGIPMSHVA	ACP1	61	P24666
ILPPHHESHAKVMMY	TBC1D7	66	Q9P0N9
TIMHGKAITVLEMDH	STXBP5L	341	Q9Y2K9
THGHSTAEEIMIKPM	ST18	86	O60284
TGHHCPTAVMVVLIM	TET1	1506	Q8NFU7
HELHAMGKLPGTRMA	CCDC146	51	Q8IYE0
IHSKHKMIAMGSAAA	APC	711	P25054
PDVRFVIHHSMSKSM	RECQL	381	P46063
SVSRTAMELKMHPHP	WDR90	1511	Q96KV7
AMELKMHPHPVALTT	WDR90	1516	Q96KV7
HPFLMTHMITHIGEK	ZNF846	126	Q147U1
AVPLMHMLHLSGALD	SPATS1	281	Q496A3
KDLSPHSRMPSMLEH	SPART-AS1	31	P0CW21
IAMQTLKHMPGHTSR	GTF2H2	151	Q13888
AHLADTMIGKAVEHM	SPIN1	126	Q9Y657
HGLASVEHMGMVLLP	SPOCD1	956	Q6ZMY3
SCPKSFRAHVMMHAG	ZNF556	241	Q9HAH1
HSMGLIHRDVKPDNM	ROCK2	206	O75116
NPMRITESHATKGHM	USF3	1921	Q68DE3
MARHVEESVKPHLAM	TRAF4	266	Q9BUZ4
AMEEVFMDKHGIHPS	VCPIP1	416	Q96JH7
LTAHMMVTGHFIKVT	TSHZ3	401	Q63HK5
HECMAPLTALVKHMH	PRKDC	2091	P78527
MAMEHGFLSKEHPLQ	ZNF536	531	O15090
MKAHQLLHSGEMPFS	ZNF786	636	Q8N393
ERHEMIAKPPVMSSH	ZNF253	66	O75346
VTSEPDMKAHLIVHM	ZUP1	11	Q96AP4
MSRVHGMHPKETTRQ	ZMYND11	41	Q15326
HPAMVTVLEMGAARH	TRAP1	606	Q12931
LMAKMAEHPEGHHDS	SLC30A5	171	Q8TAD4
SPSTLKMHMRCHTGE	ZBTB38	1021	Q8NAP3
ATHRVHMEVMPLFAG	TRAPPC10	1141	P48553
MMVISHAAPHGPEDS	SULF1	216	Q8IWU6
MIGMEHPKLFHVLDC	XXYLT1	336	Q8NBI6
EPHMPHVLIEKGDMT	VWA5B1	281	Q5TIE3
IKPMHPTSVHGVEDM	MYO7A	56	Q13402
HHIGARNIEDDPKMM	NEB	2561	P20929