Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE1A PDE3A PDE3B PDE7B	4.91e-06	22	105	4	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE1A PDE3A PDE3B PDE7B	7.07e-06	24	105	4	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE1A PDE3A PDE3B PDE7B	8.39e-06	25	105	4	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE1A PDE3A PDE3B PDE7B	1.15e-05	27	105	4	GO:0004112
GeneOntologyMolecularFunction	3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	PDE3A PDE3B	2.74e-05	2	105	2	GO:0004119
GeneOntologyMolecularFunction	D-ribulose-phosphate 3-epimerase activity	RPEL1 RPE	2.74e-05	2	105	2	GO:0004750
GeneOntologyMolecularFunction	glucosidase activity	PGGHG GANAB LCTL	6.14e-05	15	105	3	GO:0015926
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	GRIN2A RYR2 ITPR3	5.71e-04	31	105	3	GO:0099604
GeneOntologyMolecularFunction	calcium channel activity	CACNB1 GRIN2A RYR2 ITPR3 PKD1	6.00e-04	129	105	5	GO:0005262
GeneOntologyBiologicalProcess	brain development	GRIN2A PHF8 ARID1A WDR47 SHROOM4 EFNA2 NEUROD1 NEUROD2 GPR158 NKX2-1 LMX1B GLI2 CDK5RAP2 NIPBL NOTCH3	2.61e-05	859	104	15	GO:0007420
GeneOntologyBiologicalProcess	cAMP-mediated signaling	PDE1A PDE3A PDE3B PDE7B CAP1	4.11e-05	76	104	5	GO:0019933
GeneOntologyBiologicalProcess	head development	GRIN2A PHF8 ARID1A WDR47 SHROOM4 EFNA2 NEUROD1 NEUROD2 GPR158 NKX2-1 LMX1B GLI2 CDK5RAP2 NIPBL NOTCH3	5.65e-05	919	104	15	GO:0060322
Domain	NPIP	NPIPB9 NPIPB3 NPIPB5 NPIPB2 NPIPB13 NPIPA3	9.94e-11	14	109	6	IPR009443
Domain	PDEase_I	PDE1A PDE3A PDE3B PDE7B	6.09e-06	21	109	4	PF00233
Domain	PDEASE_I	PDE1A PDE3A PDE3B PDE7B	6.09e-06	21	109	4	PS00126
Domain	PDEase_CS	PDE1A PDE3A PDE3B PDE7B	6.09e-06	21	109	4	IPR023174
Domain	-	PDE1A PDE3A PDE3B PDE7B	7.40e-06	22	109	4	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE1A PDE3A PDE3B PDE7B	8.92e-06	23	109	4	IPR002073
Domain	HD/PDEase_dom	PDE1A PDE3A PDE3B PDE7B	1.07e-05	24	109	4	IPR003607
Domain	HDc	PDE1A PDE3A PDE3B PDE7B	1.07e-05	24	109	4	SM00471
Domain	Ribul_P_3_epim	RPEL1 RPE	3.37e-05	2	109	2	PF00834
Domain	RIBUL_P_3_EPIMER_1	RPEL1 RPE	3.37e-05	2	109	2	PS01085
Domain	Ribul_P_3_epim	RPEL1 RPE	3.37e-05	2	109	2	IPR026019
Domain	Ribul_P_3_epim-like	RPEL1 RPE	3.37e-05	2	109	2	IPR000056
Domain	RibuloseP-bd_barrel	RPEL1 RPE	1.01e-04	3	109	2	IPR011060
Domain	Neurogenic_DUF	NEUROD1 NEUROD2	2.01e-04	4	109	2	IPR022575
Domain	Neuro_bHLH	NEUROD1 NEUROD2	2.01e-04	4	109	2	PF12533
Domain	TF_bHLH_NeuroD	NEUROD1 NEUROD2	2.01e-04	4	109	2	IPR016637
Domain	RIH_assoc-dom	RYR2 ITPR3	4.99e-04	6	109	2	IPR013662
Domain	Ins145_P3_rec	RYR2 ITPR3	4.99e-04	6	109	2	PF08709
Domain	RIH_assoc	RYR2 ITPR3	4.99e-04	6	109	2	PF08454
Domain	RIH_dom	RYR2 ITPR3	4.99e-04	6	109	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 ITPR3	4.99e-04	6	109	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 ITPR3	4.99e-04	6	109	2	IPR015925
Domain	PKD/REJ-like	KIAA0319L PKD1	4.99e-04	6	109	2	IPR002859
Domain	-	RYR2 ITPR3	4.99e-04	6	109	2	1.25.10.30
Domain	REJ	KIAA0319L PKD1	4.99e-04	6	109	2	PF02010
Domain	RYDR_ITPR	RYR2 ITPR3	4.99e-04	6	109	2	PF01365
Domain	ANK_REPEAT	MUC16 DAPK1 PSMD10 ANKRD13A TNNI3K HACE1 NOTCH3	7.10e-04	253	109	7	PS50088
Domain	ANK_REP_REGION	MUC16 DAPK1 PSMD10 ANKRD13A TNNI3K HACE1 NOTCH3	7.27e-04	254	109	7	PS50297
Domain	PKD/Chitinase_dom	KIAA0319L PKD1	1.18e-03	9	109	2	IPR022409
Domain	PKD	KIAA0319L PKD1	1.18e-03	9	109	2	SM00089
Domain	MIR	RYR2 ITPR3	1.47e-03	10	109	2	PF02815
Domain	MIR_motif	RYR2 ITPR3	1.47e-03	10	109	2	IPR016093
Domain	MIR	RYR2 ITPR3	1.47e-03	10	109	2	PS50919
Domain	MIR	RYR2 ITPR3	1.47e-03	10	109	2	SM00472
Domain	PKD	KIAA0319L PKD1	1.79e-03	11	109	2	PS50093
Domain	PKD_dom	KIAA0319L PKD1	1.79e-03	11	109	2	IPR000601
Domain	-	KIAA0319L PKD1	1.79e-03	11	109	2	2.60.40.670
Domain	-	UTP23 DIS3	2.14e-03	12	109	2	3.40.50.1010
Domain	Ank	DAPK1 PSMD10 ANKRD13A TNNI3K HACE1 NOTCH3	2.21e-03	228	109	6	PF00023
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE1A PDE3A PDE3B GRIN2A PDE7B	8.04e-06	55	71	5	M39763
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ACACB MUC16 ARID1A CCDC85A RYR2 ITPR3 CEP350 TXNDC5 PTPRN2 TLE3 CDK5RAP2 HFM1 NIPBL	1.69e-07	638	113	13	31182584
Pubmed	Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.	ETV1 SIM1 NEUROD1 NEUROD2	3.94e-07	19	113	4	33492553
Pubmed	Overview of PDEs and their regulation.	PDE1A PDE3A PDE3B PDE7B	1.27e-06	25	113	4	17307970
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE1A PDE3A PDE3B	9.33e-06	13	113	3	8557689
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	SIM1 CCDC85A TNNI3K PTPRN2 RBM6 FUT8	9.68e-06	149	113	6	25231870
Pubmed	The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.	NEUROD1 NEUROD2	1.05e-05	2	113	2	11900979
Pubmed	Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects.	TCF4 NEUROD2	1.05e-05	2	113	2	22460224
Pubmed	Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human.	ETV1 MEOX2	1.05e-05	2	113	2	10597226
Pubmed	A pathophysiological role of PDE3 in allergic airway inflammation.	PDE3A PDE3B	1.05e-05	2	113	2	29367458
Pubmed	Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.	RYR2 ITPR3	1.05e-05	2	113	2	18586264
Pubmed	Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.	PDE3A PDE3B	1.05e-05	2	113	2	17482796
Pubmed	Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.	PDE3A PDE3B	1.05e-05	2	113	2	25877153
Pubmed	Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.	PDE3A PDE3B	1.05e-05	2	113	2	31051182
Pubmed	Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.	PDE3A PDE3B	1.05e-05	2	113	2	39435735
Pubmed	Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.	RYR2 ITPR3	1.05e-05	2	113	2	24285081
Pubmed	Serotonin signaling in the brain of adult female mice is required for sexual preference.	LMX1B TPH2	1.05e-05	2	113	2	23716677
Pubmed	Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins.	PDE3A PDE3B	1.05e-05	2	113	2	21632535
Pubmed	Notch signaling modulates MUC16 biosynthesis in an in vitro model of human corneal and conjunctival epithelial cell differentiation.	MUC16 NOTCH3	1.05e-05	2	113	2	21508102
Pubmed	Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice.	LMX1B TPH2	1.05e-05	2	113	2	21441904
Pubmed	A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.	MEOX2 PKD1	1.05e-05	2	113	2	15579506
Pubmed	NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum.	NEUROD1 NEUROD2	1.05e-05	2	113	2	30723302
Pubmed	Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.	PDE1A PDE3A PDE3B	1.18e-05	14	113	3	25852085
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	ARID1A DIS3 TXNDC5 RBM27 TLE3 RBM6 ZNF638 CAP1 CPSF7	1.93e-05	457	113	9	32344865
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	PTPRN2 GLI2 PKD1 ZNF638 CDK5RAP2 PDE7B	2.12e-05	171	113	6	20201926
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	ACACB KIAA0319L RBM27 RBM6 NOTCH3 CPSF7	2.82e-05	180	113	6	35198878
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CDK8 ARID1A RBM27 TLE3 TADA2B NIPBL CPSF7	2.87e-05	268	113	7	33640491
Pubmed	Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice.	MEOX2 TPH2	3.13e-05	3	113	2	33041772
Pubmed	Comparative mapping of human Chromosome 14q11.2-q13 genes with mouse homologous gene regions.	MEOX2 NKX2-1	3.13e-05	3	113	2	11063256
Pubmed	Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1.	PDE3A PDE3B	3.13e-05	3	113	2	8921398
Pubmed	Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.	NEUROD1 NEUROD2	3.13e-05	3	113	2	17924961
Pubmed	Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells.	LMX1B TPH2	3.13e-05	3	113	2	25294992
Pubmed	Association between KIAA0319L, PXK and JAZF1 gene polymorphisms and unexplained recurrent pregnancy loss in Chinese Han couples.	KIAA0319L PXK	3.13e-05	3	113	2	25596907
Pubmed	Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect.	GALK1 ITPR3	3.13e-05	3	113	2	6510705
Pubmed	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE).	RPEL1 RPE	3.13e-05	3	113	2	7396409
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	3.13e-05	3	113	2	11948212
Pubmed	NeuroD1 is an upstream regulator of NSCL1.	NEUROD1 NEUROD2	3.13e-05	3	113	2	22310718
Pubmed	Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis.	MEOX2 PKD1	3.13e-05	3	113	2	37845212
Pubmed	NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.	NEUROD1 NEUROD2	3.13e-05	3	113	2	8816493
Pubmed	Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation.	PDE3A PDE3B	3.13e-05	3	113	2	32949251
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXJ2 TCF4 ETV1 ZHX2 MEOX2 ZNF16 NEUROD1 NEUROD2 NKX2-1 LMX1B GLI2 TADA2B	4.12e-05	908	113	12	19274049
Pubmed	Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.	PDE1A PDE3A PDE3B	4.26e-05	21	113	3	27740716
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SLAIN2 ACACB KIAA0319L MUC16 USP19 RYR2 CDC42EP1 CEP350 IARS2 ZNF638 CDK5RAP2	4.75e-05	777	113	11	35844135
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	TCF4 ACACB MUC16 ITPR3 GANAB TIAL1 RBM27 RPE	4.76e-05	396	113	8	26687479
Pubmed	Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity.	MEOX2 LMX1B GLI2	5.64e-05	23	113	3	22987640
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PHF8 ZHX2 USP19 WDR47 GANAB MROH1 SGSM2 TLE3	5.76e-05	407	113	8	12693553
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	ETV1 SIM1 NEUROD1 NKX2-1 TLE3	5.92e-05	126	113	5	16284245
Pubmed	Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.	ABCA3 NKX2-1	6.25e-05	4	113	2	17890326
Pubmed	USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.	TCF4 TLE3	6.25e-05	4	113	2	36749823
Pubmed	Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease.	PKD1 NOTCH3	6.25e-05	4	113	2	29463793
Pubmed	Genetic basis for childhood interstitial lung disease among Japanese infants and children.	ABCA3 NKX2-1	6.25e-05	4	113	2	29569581
Pubmed	Lmx1b is required at multiple stages to build expansive serotonergic axon architectures.	LMX1B TPH2	6.25e-05	4	113	2	31355748
Pubmed	RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.	TCF4 TLE3	6.25e-05	4	113	2	29374067
Pubmed	An adult-stage transcriptional program for survival of serotonergic connectivity.	LMX1B TPH2	6.25e-05	4	113	2	35443166
Pubmed	NeuroD factors regulate cell fate and neurite stratification in the developing retina.	NEUROD1 NEUROD2	6.25e-05	4	113	2	21593321
Pubmed	Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.	SIM1 GLI2	6.25e-05	4	113	2	11023872
Pubmed	Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy.	MEOX2 LTBP4	6.25e-05	4	113	2	25070948
Pubmed	Isolated polycystic liver disease genes define effectors of polycystin-1 function.	GANAB PKD1	6.25e-05	4	113	2	28375157
Pubmed	Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?	MUC16 NKX2-1	6.25e-05	4	113	2	17413979
Pubmed	The Growth arrest specific 1 (Gas1) gene is transcriptionally regulated by NeuroD1 via two distal E-boxes.	NEUROD1 NEUROD2	6.25e-05	4	113	2	29395133
Pubmed	A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.	RYR2 TNNI3K	6.25e-05	4	113	2	33664309
Pubmed	Regulation of neuroD2 expression in mouse brain.	NEUROD1 NEUROD2	6.25e-05	4	113	2	14697366
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	ARID1A RBM27 TLE3 TADA2B CPSF7	7.92e-05	134	113	5	25452129
Pubmed	AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.	ETV1 NEUROD1 CDH4	8.22e-05	26	113	3	19749747
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE1A PDE3A PDE3B	9.23e-05	27	113	3	11156964
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	SLAIN2 PSMD10 PHF8 HDHD2 DIS3 TXNDC5	9.27e-05	223	113	6	33187986
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDK8 PDE3B ETV1 ARID1A ZHX2 PTPRN2 GPR158 GLI2 SGSM2 TLE3 TBCK RBM6 ZNF638 ENPP5 NOTCH3	9.76e-05	1489	113	15	28611215
Pubmed	Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.	EFNA2 CDH4	1.04e-04	5	113	2	10477297
Pubmed	Cell adhesion molecules and extracellular-matrix constituents in kidney development and disease.	LMX1B PKD1	1.04e-04	5	113	2	10547347
Pubmed	Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions.	SIM1 NKX2-1	1.04e-04	5	113	2	22264356
Pubmed	Notch expression in developing olfactory neuroepithelium.	NEUROD1 NOTCH3	1.04e-04	5	113	2	15076712
Pubmed	Expression of classical cadherins in thyroid development: maintenance of an epithelial phenotype throughout organogenesis.	NKX2-1 CDH4	1.04e-04	5	113	2	12865344
Pubmed	Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis.	GLI2 PKD1	1.04e-04	5	113	2	21151991
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXJ2 TCF4 ETV1 SIM1 ARID1A MEOX2 NEUROD2 NKX2-1 GLI2 ZNF638	1.10e-04	709	113	10	22988430
Pubmed	pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.	NEUROD1 GLI2 NOTCH3	1.27e-04	30	113	3	17257418
Pubmed	Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.	PDE1A NKX2-1 PDE7B	1.40e-04	31	113	3	28942923
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 ITPR3	1.56e-04	6	113	2	23463619
Pubmed	The mouse kinome: discovery and comparative genomics of all mouse protein kinases.	PXK TBCK	1.56e-04	6	113	2	15289607
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 ITPR3	1.56e-04	6	113	2	25966694
Pubmed	Molecular embryology of the lung: then, now, and in the future.	NKX2-1 GLI2	1.56e-04	6	113	2	10330024
Pubmed	Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.	MEOX2 PKD1	1.56e-04	6	113	2	17575307
Pubmed	Origin and molecular specification of globus pallidus neurons.	ETV1 NKX2-1	1.56e-04	6	113	2	20181580
Pubmed	Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model.	NKX2-1 GLI2	1.56e-04	6	113	2	27585885
Pubmed	Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.	NEUROD1 GLI2	1.56e-04	6	113	2	14681189
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 ITPR3	1.56e-04	6	113	2	20519450
Pubmed	The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells.	RPEL1 RPE	1.56e-04	6	113	2	5360673
Pubmed	A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes.	CACNB1 GRIN2A	1.56e-04	6	113	2	21883149
Pubmed	ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.	RYR2 ITPR3	1.56e-04	6	113	2	16352659
Pubmed	Time-resolved proteome profiling of normal lung development.	ABCA3 NKX2-1	1.56e-04	6	113	2	29516783
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 ITPR3	1.56e-04	6	113	2	16844763
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PSMD10 PHF8 ARID1A ITPR3 CDC42EP1 CEP350 GANAB TXNDC5 PTPRN2 TLE3 ZNF638 CDK5RAP2	1.61e-04	1049	113	12	27880917
Pubmed	Convergence of the insulin and serotonin programs in the pancreatic β-cell.	NEUROD1 LMX1B TPH2	1.86e-04	34	113	3	22013016
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 ITPR3	2.17e-04	7	113	2	11860456
Pubmed	Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.	PHF8 PTPRN2	2.17e-04	7	113	2	21057379
Pubmed	Polycystic Kidney Disease, Autosomal Dominant	GANAB PKD1	2.17e-04	7	113	2	20301424
Pubmed	Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem.	LMX1B TPH2	2.17e-04	7	113	2	24972638
Pubmed	Calretinin-positive L5a pyramidal neurons in the development of the paralemniscal pathway in the barrel cortex.	ETV1 NEUROD2	2.17e-04	7	113	2	25404384
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	NPIPB9 NPIPB11 NPIPB3 NPIPB2	2.18e-04	90	113	4	15616553
Pubmed	Human transcription factor protein interaction networks.	TCF4 ACACB PHF8 ARID1A ZHX2 GANAB RBM27 GLI2 TLE3 TADA2B RBM6 ZNF638 NIPBL CPSF7	2.26e-04	1429	113	14	35140242
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	NPIPB4 SYT17 ZP2 PKD1	2.37e-04	92	113	4	10493829
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNB1 RYR2 ITPR3	2.59e-04	38	113	3	30786075
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 SYT17 NPIPB3 NPIPB5 ZP2	7.05e-05	172	113	5	chr16p12
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	1.06e-04	37	113	3	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q34	SPAG16 RPE UNC80	1.91e-04	45	113	3	chr2q34
GeneFamily	Phosphodiesterases	PDE1A PDE3A PDE3B PDE7B	2.44e-06	24	73	4	681
GeneFamily	Basic helix-loop-helix proteins	TCF4 SIM1 NEUROD1 NEUROD2	1.02e-03	110	73	4	420
GeneFamily	RNA binding motif containing	TIAL1 RBM27 RBM6 ZNF638 CPSF7	1.70e-03	213	73	5	725
GeneFamily	Aminoacyl tRNA synthetases, Class I	CARS1 IARS2	2.63e-03	19	73	2	131
GeneFamily	Ankyrin repeat domain containing	DAPK1 PSMD10 ANKRD13A HACE1 NOTCH3	2.96e-03	242	73	5	403
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	FKBP10 TCF4 PDE3A RYR2 MEOX2 GLI2 LTBP4	7.74e-07	199	113	7	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	PGGHG B3GNT3 ZP2 NKX2-1 SGSM2 NOTCH3	5.88e-06	176	113	6	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	(5)_Epithelial_cells-(5)_Glands_mucous\|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	GALNTL6 FKBP10 ETV1 MUC16 RYR2 PTPRN2	6.68e-06	180	113	6	a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TCF4 PDE1A PDE3A CCDC85A PDE7B NOTCH3	7.12e-06	182	113	6	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A SYT17 GRIN2A RYR2 PTPRN2 SGSM2	8.31e-06	187	113	6	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A SYT17 GRIN2A RYR2 PTPRN2 SGSM2	8.31e-06	187	113	6	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A SYT17 GRIN2A RYR2 PTPRN2 SGSM2	8.31e-06	187	113	6	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	TCF4 PDE3B DAPK1 MEOX2 LTBP4 CDH4	9.10e-06	190	113	6	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	facs-Pancreas-Endocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B PAIP2 ETV1 NEUROD1 PTPRN2 UNC80	9.38e-06	191	113	6	b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PDE1A PDE3A GLI2 LTBP4 PDE7B NOTCH3	9.38e-06	191	113	6	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA3 HDHD2 USP19 ITPR3 TBC1D8 SLC27A1	1.02e-05	194	113	6	df835578d86a49ae5af5632152fbab9548c0a448
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA3 HDHD2 USP19 ITPR3 TBC1D8 SLC27A1	1.02e-05	194	113	6	0715f2d55f4a6d2edda1b3dc52f12d25ce59eb10
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA3 HDHD2 USP19 ITPR3 TBC1D8 SLC27A1	1.02e-05	194	113	6	a4f7cd507eba40985d82635bbae28c7f5703f883
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A RYR2 PTPRN2 GPR158 PKD1 UNC80	1.09e-05	196	113	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE1A PDE3A GRIN2A RYR2 MEOX2 NOTCH3	1.12e-05	197	113	6	cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A ABCA3 GRIN2A RYR2 HFM1 NOTCH3	1.15e-05	198	113	6	1e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FKBP10 TCF4 PDE3A RYR2 MEOX2 GLI2	1.15e-05	198	113	6	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	Control-Neu_0\|World / 5 Neutrophil clusters in COVID-19 patients	CACNB1 PGGHG EFNA2 LMX1B NOTCH3	1.38e-05	120	113	5	840d0ac995e2fa41996514753e4e03c4aa4a26d0
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SIM1 ERICH5 NEUROD1 NEUROD2	4.00e-05	75	113	4	3bc5df14f21c1c93c2a0fd5fc47bc5d146ba87a2
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	GALNTL6 RYR2 PTPRN2 GPR158 CDH4	5.34e-05	159	113	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CACNB1 RYR2 CEP350 NPIPB13 RBM6	6.55e-05	166	113	5	26f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 MUC16 DAPK1 NPIPB2 NPIPB13	6.74e-05	167	113	5	8b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP2C19 NPIPB4 ACACB TBC1D8 RBM27	6.93e-05	168	113	5	4e2e4c88ada772e9ba6e72c9ae3a05c063e93318
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP2C19 NPIPB4 ACACB TBC1D8 RBM27	6.93e-05	168	113	5	ee4dab089adef2f47a9d39d91934523331a8b81c
ToppCell	facs-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A NRAP B3GNT3 SHROOM4 LTBP4	7.33e-05	170	113	5	8e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCell	facs-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A NRAP B3GNT3 SHROOM4 LTBP4	7.33e-05	170	113	5	67d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	PDE1A PDE3A RYR2 PHYHIPL NOTCH3	7.75e-05	172	113	5	c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A EFS NPIPB11 PTPRN2 CDH4	7.96e-05	173	113	5	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C2orf69 PGGHG SYT17 PROZ LTBP4	8.18e-05	174	113	5	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	TCF4 PDE1A PDE3A PDE7B NOTCH3	9.35e-05	179	113	5	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A PDE3B ACACB ANKRD13A PDE7B	9.35e-05	179	113	5	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	renal_papilla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	TCF4 PGGHG B3GNT3 FUT8 PDE7B	9.60e-05	180	113	5	49829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ABCA3 PGGHG SYT17 CCDC85A NKX2-1	1.04e-04	183	113	5	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A SYT17 RYR2 PDE7B NOTCH3	1.04e-04	183	113	5	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A SYT17 RYR2 PDE7B NOTCH3	1.06e-04	184	113	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 CEP350 ZNF638 PLEKHM3 NIPBL	1.06e-04	184	113	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ACACB KIAA0319L DAPK1 TBC1D8 TBCK	1.09e-04	185	113	5	1d874608aa2062024323512f68889219471b2f00
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETV1 GRIN2A SIM1 BCO1 PHYHIPL	1.12e-04	186	113	5	2f103ce2427f9cf2c1fafb6bd6045c5863a47549
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ACACB KIAA0319L TBCK ZNF638 PHYHIPL	1.15e-04	187	113	5	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FKBP10 TCF4 ETV1 MEOX2 NEUROD1	1.15e-04	187	113	5	db771e952f71a12886c2dbc77c6cd07054ef809a
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	ABCA3 ETV1 ITPR3 SHROOM4 NKX2-1	1.21e-04	189	113	5	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A RYR2 LTBP4 PDE7B NOTCH3	1.21e-04	189	113	5	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TCF4 PDE3A ITPR3 FUT8 LTBP4	1.21e-04	189	113	5	12b6f1c3bf526b90e112374bf937701f645c5780
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PDE3A ZHX2 RYR2 CDC42EP1 NOTCH3	1.21e-04	189	113	5	9c2492c38f27e4c699b40680652e4c64911cce52
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	TCF4 PDE1A DAPK1 SHROOM4 PDE7B	1.21e-04	189	113	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A ACACB DAPK1 SIM1 PDE7B	1.21e-04	189	113	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FKBP10 PDE3A RYR2 GLI2 NOTCH3	1.21e-04	189	113	5	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TCF4 PDE3A CCDC85A FUT8 LTBP4	1.24e-04	190	113	5	bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell	droplet-Fat-Scat-21m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 CCDC85A MEOX2 CDC42EP1 LTBP4	1.24e-04	190	113	5	d3e46cf800a07ca9b01c78192962d223b9785d05
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GRIN2A RYR2 PTPRN2 GPR158 UNC80	1.24e-04	190	113	5	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACACB DAPK1 ANKRD13A CD33 TADA2B	1.24e-04	190	113	5	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	droplet-Fat-Scat-21m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 CCDC85A MEOX2 CDC42EP1 LTBP4	1.24e-04	190	113	5	dd89ef1ecea20b2f6fbdc6cea4ca41b28b3ed822
ToppCell	Mesenchymal_cells-Smooth_muscle\|World / Lineage and Cell class	PDE1A PDE3A CCDC85A MEOX2 NOTCH3	1.24e-04	190	113	5	5aa62a363a25f4a110136263b21289a11e8c1e6d
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A RYR2 MEOX2 GLI2 LTBP4	1.27e-04	191	113	5	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FKBP10 PDE3A RYR2 MEOX2 GLI2	1.27e-04	191	113	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 PDE3A RYR2 GLI2 NOTCH3	1.27e-04	191	113	5	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA3 DAPK1 ITPR3 SHROOM4 NKX2-1	1.27e-04	191	113	5	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B ETV1 NEUROD1 PTPRN2 UNC80	1.27e-04	191	113	5	657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCell	facs-BAT-Fat-18m-Endothelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 CCDC85A MEOX2 CDC42EP1 LTBP4	1.30e-04	192	113	5	3a99c521c599a289ee2309d97be5ceb99f8aa220
ToppCell	facs-BAT-Fat-18m-Endothelial-endothelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 CCDC85A MEOX2 CDC42EP1 LTBP4	1.30e-04	192	113	5	f9777e0fdd86c2a514f05a42502888329a94b396
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A RYR2 LTBP4 PDE7B NOTCH3	1.30e-04	192	113	5	992d08092edbc68c47b945deb8708379738c239a
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FKBP10 PDE1A LTBP4 CDH4 NOTCH3	1.30e-04	192	113	5	dc4b4e16e6eb212e45fb70695afd1c7e91027407
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA3 KIAA0319L DAPK1 ITPR3 NKX2-1	1.30e-04	192	113	5	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	facs-BAT-Fat-18m-Endothelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 CCDC85A MEOX2 CDC42EP1 LTBP4	1.30e-04	192	113	5	562e15876088af9189744c9b2de5c4863d7f15fd
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	TCF4 CCDC85A MEOX2 SHROOM4 PDE7B	1.30e-04	192	113	5	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A RYR2 MEOX2 GLI2 LTBP4	1.30e-04	192	113	5	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	LPS-IL1RA-Stromal_mesenchymal\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A RYR2 MEOX2 GLI2 LTBP4	1.30e-04	192	113	5	4e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA3 ETV1 ITPR3 SHROOM4 NKX2-1	1.30e-04	192	113	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A RYR2 MEOX2 GLI2 LTBP4	1.30e-04	192	113	5	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NPIPB4 DAPK1 NPIPB3 NPIPB5 ZHX2	1.33e-04	193	113	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FKBP10 ACACB PGGHG ZHX2 GLI2	1.33e-04	193	113	5	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	C2orf69 PDE3B ARID1A CEP350 GANAB	1.33e-04	193	113	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FKBP10 ACACB PGGHG ZHX2 GLI2	1.33e-04	193	113	5	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA3 DAPK1 ITPR3 SHROOM4 NKX2-1	1.33e-04	193	113	5	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	GALNTL6 TCF4 PDE3A SYT17 GRIN2A	1.36e-04	194	113	5	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	GALNTL6 TCF4 PDE3A SYT17 GRIN2A	1.36e-04	194	113	5	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TCF4 PDE3B MEOX2 GLI2 CDH4	1.36e-04	194	113	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ETV1 RYR2 MEOX2 GLI2 CDH4	1.36e-04	194	113	5	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A RYR2 MEOX2 GLI2 LTBP4	1.36e-04	194	113	5	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TCF4 PDE3B ETV1 MEOX2 GLI2	1.40e-04	195	113	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TCF4 NPIPB4 ACACB DIS3 TXNDC5	1.40e-04	195	113	5	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A GRIN2A GLI2 LTBP4 NOTCH3	1.40e-04	195	113	5	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A GRIN2A MEOX2 GLI2 LTBP4	1.40e-04	195	113	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A DAPK1 GRIN2A CCDC85A PDE7B	1.40e-04	195	113	5	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCF4 PDE1A SYT17 CDC42EP1 LTBP4	1.40e-04	195	113	5	bad7f2162000f29488b3c4b903dcac9a818621f7
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FKBP10 RYR2 MEOX2 GLI2 LTBP4	1.43e-04	196	113	5	525d6c8a277364e624e7cc586275f8a891436b57
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FKBP10 PDE3A RYR2 MEOX2 GLI2	1.43e-04	196	113	5	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	TCF4 PDE3B GRIN2A CCDC85A SHROOM4	1.43e-04	196	113	5	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	356C-Epithelial_cells-Epithelial-B_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ABCA3 ETV1 ITPR3 CDC42EP1 NKX2-1	1.46e-04	197	113	5	06ed8f293d4ee89f14dc2f43d6cae93bbc02508a
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TCF4 PDE3A ZP2 RYR2 NOTCH3	1.46e-04	197	113	5	f66945f9007d59d4208849c7fd727f8519713fbc
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TCF4 SIM1 NEUROD1 NEUROD2 NKX2-1	1.46e-04	197	113	5	b4554353c56e220bae31ee3c8aa222674dd0b18c
ToppCell	PCW_13-14-Mesenchymal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TCF4 ETV1 MEOX2 GLI2 LTBP4	1.46e-04	197	113	5	73a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TCF4 PDE3A ZP2 RYR2 NOTCH3	1.46e-04	197	113	5	41dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCell	356C-Epithelial_cells-Epithelial-B_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ABCA3 ETV1 ITPR3 CDC42EP1 NKX2-1	1.46e-04	197	113	5	c115d0a45545ed24259ad88872231bf4d4d389d2
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	FKBP10 PDE3A RYR2 MEOX2 GLI2	1.46e-04	197	113	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	AT2_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ABCA3 ETV1 ITPR3 CDC42EP1 NKX2-1	1.46e-04	197	113	5	8b5d4e1c33a57c899c51feb9a6f347232f8910a3
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	TCF4 PDE3B ETV1 RYR2 MEOX2	1.46e-04	197	113	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A RYR2 PTPRN2 PKD1 UNC80	1.50e-04	198	113	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A RYR2 PTPRN2 GPR158 UNC80	1.50e-04	198	113	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	FKBP10 PDE3A RYR2 MEOX2 GLI2	1.50e-04	198	113	5	26e55b409db2a1637c95fae7c54b0abea1ef550c
Drug	felodipine	CACNB1 PDE1A PDE3A PDE3B CYP2C19 RYR2 ITPR3 PKD1 PDE7B	1.15e-07	169	108	9	CID000003333
Drug	T-440	PDE1A PDE3A PDE3B PTPRN2 PDE7B	1.33e-07	26	108	5	CID000177965
Drug	papaverine	CACNB1 PDE1A PDE3A PDE3B RYR2 ITPR3 PKD1 PDE7B	1.98e-06	176	108	8	CID000004680
Drug	AA-2379	PDE1A PDE3A PDE3B PDE7B	2.69e-06	21	108	4	CID000128390
Drug	HWA 153	PDE1A PDE3A PDE3B PDE7B	3.28e-06	22	108	4	CID000162797
Drug	griseolic acid	PDE1A PDE3A PDE3B PDE7B	3.95e-06	23	108	4	CID000127607
Drug	atherosperminine	PDE1A PDE3A PDE3B PDE7B	3.95e-06	23	108	4	CID000096918
Drug	Loxapine succinate [27833-64-3]; Down 200; 9uM; PC3; HT_HG-U133A	FKBP10 TCF4 ABCA3 ETV1 PTPRN2 SGSM2 TLE3 NOTCH3	4.58e-06	197	108	8	6694_DN
Drug	desethyl KBT-3022	PDE1A PDE3A PDE3B PDE7B	6.60e-06	26	108	4	CID000127736
Drug	Ro 15-2041	PDE1A PDE3A PDE3B PDE7B	6.60e-06	26	108	4	CID000132434
Drug	Cinildipine	CACNB1 EFS RYR2 ITPR3 PKD1	6.89e-06	56	108	5	CID000002752
Drug	PF-04254644	PDE1A PDE3A PDE3B	8.54e-06	9	108	3	ctd:C551178
Drug	imidazole-4-carboxamide	PDE1A PDE3A PDE3B PDE7B	1.55e-05	32	108	4	CID000152917
Drug	CNS 1145	CACNB1 RYR2 ITPR3 PKD1	1.76e-05	33	108	4	CID000190902
Drug	IHC-64	CACNB1 RYR2 ITPR3 PKD1	1.76e-05	33	108	4	CID000162753
Drug	dyphylline	PDE1A PDE3A PDE3B PDE7B	1.76e-05	33	108	4	CID000003182
Drug	lamotrigine	CACNB1 CYP2C19 GRIN2A RYR2 ITPR3 PKD1	1.93e-05	116	108	6	CID000003878
Drug	Inocor (TN)	PDE3A PDE3B	2.23e-05	2	108	2	CID000656683
Drug	RS-1893	PDE3A PDE3B	2.23e-05	2	108	2	CID000128386
Drug	lomustine; Down 200; 100uM; PC3; HT_HG-U133A	TCF4 ACACB ETV1 ZHX2 TBC1D8 TIAL1 SPAG16	2.45e-05	180	108	7	7094_DN
Drug	AH 21-132	PDE1A PDE3A PDE3B PDE7B	2.80e-05	37	108	4	CID003035793
Drug	Cyclacillin [3485-14-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	TCF4 CACNB1 SYT17 B3GNT3 PHF8 PTPRN2 GLI2	3.82e-05	193	108	7	4536_UP
Drug	Ergocryptine-alpha [511-09-1]; Up 200; 7uM; PC3; HT_HG-U133A	PDE3B ABCA3 ETV1 DAPK1 B3GNT3 PTPRN2 LMX1B	3.95e-05	194	108	7	4552_UP
Drug	2-propylpentanoic acid; Up 200; 1000uM; PC3; HT_HG-U133A	CACNB1 ACACB PGGHG ETV1 PTPRN2 GLI2 NOTCH3	4.35e-05	197	108	7	4433_UP
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; PC3; HT_HG-U133A	FKBP10 PDE3B SYT17 ETV1 ARID1A PTPRN2 SGSM2	4.35e-05	197	108	7	4226_UP
Drug	Prilocaine hydrochloride [1786-81-8]; Up 200; 15.6uM; PC3; HT_HG-U133A	CACNB1 KIAA0319L ITPR3 PROZ PTPRN2 LMX1B LTBP4	4.35e-05	197	108	7	3727_UP
Drug	Etofylline [519-37-9]; Up 200; 17.8uM; PC3; HT_HG-U133A	FKBP10 CACNB1 SYT17 KIAA0319L RYR2 NEUROD1 NOTCH3	4.64e-05	199	108	7	5048_UP
Drug	Decamethonium bromide [541-22-0]; Down 200; 9.6uM; HL60; HT_HG-U133A	GIN1 ARID1A USP19 PTPRN2 TLE3 FUT8 NIPBL	4.64e-05	199	108	7	2933_DN
Drug	SureCN4406168	PDE3A PDE3B	6.67e-05	3	108	2	CID011502028
Drug	SureCN4395097	PDE3A PDE3B	6.67e-05	3	108	2	CID011610011
Drug	SureCN4401117	PDE3A PDE3B	6.67e-05	3	108	2	CID011718172
Drug	SureCN4402206	PDE3A PDE3B	6.67e-05	3	108	2	CID011516917
Drug	WIN 62582	PDE3A PDE3B	6.67e-05	3	108	2	CID005487388
Drug	SureCN4397066	PDE3A PDE3B	6.67e-05	3	108	2	CID011538627
Drug	SureCN4401121	PDE3A PDE3B	6.67e-05	3	108	2	CID011611819
Drug	SureCN4404748	PDE3A PDE3B	6.67e-05	3	108	2	CID011502895
Drug	SureCN4411688	PDE3A PDE3B	6.67e-05	3	108	2	CID011523192
Drug	SureCN4405038	PDE3A PDE3B	6.67e-05	3	108	2	CID011546172
Drug	SureCN4405912	PDE3A PDE3B	6.67e-05	3	108	2	CID011682920
Drug	pelrinone	PDE3A PDE3B	6.67e-05	3	108	2	CID000055919
Drug	SureCN4398032	PDE3A PDE3B	6.67e-05	3	108	2	CID011532088
Drug	SureCN4406373	PDE3A PDE3B	6.67e-05	3	108	2	CID011711104
Drug	SureCN4394894	PDE3A PDE3B	6.67e-05	3	108	2	CID011711103
Drug	SureCN5995113	PDE3A PDE3B	6.67e-05	3	108	2	CID011640499
Drug	CHEMBL219123	PDE3A PDE3B	6.67e-05	3	108	2	CID016102624
Drug	germitrine	PDE3A PDE3B	6.67e-05	3	108	2	CID000011217
Drug	SureCN4411840	PDE3A PDE3B	6.67e-05	3	108	2	CID011567407
Drug	SureCN4401113	PDE3A PDE3B	6.67e-05	3	108	2	CID011544858
Drug	SureCN4405883	PDE3A PDE3B	6.67e-05	3	108	2	CID011516351
Drug	SureCN4407211	PDE3A PDE3B	6.67e-05	3	108	2	CID011553351
Drug	SureCN4401096	PDE3A PDE3B	6.67e-05	3	108	2	CID011710801
Drug	nicardipine	CACNB1 CYP2C19 RYR2 ITPR3 BCO1 PKD1	6.75e-05	145	108	6	CID000004473
Drug	isradipine	CACNB1 GIN1 RYR2 ITPR3 PKD1	1.15e-04	100	108	5	CID000003784
Drug	R 80122	PDE3A PDE3B	1.33e-04	4	108	2	CID009571043
Drug	isomazole	PDE3A PDE3B	1.33e-04	4	108	2	CID000055689
Drug	UK-1745	PDE3A PDE3B	1.33e-04	4	108	2	CID003035852
Drug	nanterinone	PDE3A PDE3B	1.33e-04	4	108	2	CID000071305
Drug	loperamide	CACNB1 GRIN2A RYR2 ITPR3 PKD1	1.45e-04	105	108	5	CID000003954
Drug	theophylline	PDE1A PDE3A PDE3B CYP2C19 NEUROD1 PTPRN2 PDE7B	1.54e-04	241	108	7	CID000002153
Drug	gabapentin	CACNB1 CYP2C19 GRIN2A RYR2 ITPR3 PKD1	1.57e-04	169	108	6	CID000003446
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	ARID1A ZHX2 ZNF16 SGSM2 CDK5RAP2 CPSF7	1.62e-04	170	108	6	5417_DN
Drug	lavendustin A	CACNB1 GRIN2A RYR2 ITPR3 TIAL1 PKD1	1.67e-04	171	108	6	CID000003894
Drug	nilvadipine	CACNB1 RYR2 ITPR3 PKD1	1.90e-04	60	108	4	CID000004494
Drug	imidazolone	PDE3A PDE3B RYR2	1.95e-04	24	108	3	CID000000504
Drug	IAA-94	CACNB1 RYR2 ITPR3 PKD1	2.03e-04	61	108	4	CID000003667
Drug	adibendan	PDE3A PDE3B	2.21e-04	5	108	2	CID000065867
Drug	enoximone sulfoxide	PDE3A PDE3B	2.21e-04	5	108	2	CID000158474
Drug	lercanidipine	CACNB1 RYR2 ITPR3 PKD1	2.30e-04	63	108	4	CID000065866
Drug	gallopamil	CACNB1 RYR2 ITPR3 PKD1	2.92e-04	67	108	4	CID000001234
Drug	Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	FKBP10 TCF4 PGGHG EFS RYR2 GLI2	3.21e-04	193	108	6	3183_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; PC3; HT_HG-U133A	FKBP10 KIAA0319L ETV1 ZHX2 DIS3 NOTCH3	3.21e-04	193	108	6	4285_DN
Drug	AC1L2AC7	CACNB1 RYR2 ITPR3 PKD1	3.27e-04	69	108	4	CID000068733
Drug	Coralyne chloride hydrate [38989-38-7]; Up 200; 9.6uM; MCF7; HT_HG-U133A	CACNB1 PDE3B ETV1 BCO1 CDC42EP1 LTBP4	3.30e-04	194	108	6	5418_UP
Drug	Clobetasol propionate [25122-46-7]; Up 200; 8.6uM; MCF7; HT_HG-U133A	FOXJ2 FKBP10 CACNB1 KIAA0319L B3GNT3 MAP4K2	3.30e-04	194	108	6	6835_UP
Drug	saterinone	PDE3A PDE3B	3.30e-04	6	108	2	CID000065874
Drug	RP-217	PDE3A PDE3B	3.30e-04	6	108	2	CID006093445
Drug	EMD 60263	PDE3A PDE3B	3.30e-04	6	108	2	CID000187063
Drug	AWD 122-14	PDE3A PDE3B	3.30e-04	6	108	2	CID000130952
Drug	AC1L19RO	EFS ZP2	3.30e-04	6	108	2	CID000025796
Drug	Glipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A	ACACB EFS RYR2 NEUROD1 LMX1B NOTCH3	3.39e-04	195	108	6	4991_UP
Drug	Butylparaben [94-26-8]; Up 200; 20.6uM; MCF7; HT_HG-U133A	CACNB1 PDHA2 CDC42EP1 LMX1B LTBP4 NOTCH3	3.39e-04	195	108	6	5608_UP
Drug	Guaifenesin [93-14-1]; Up 200; 20.2uM; PC3; HT_HG-U133A	B3GNT3 TIAL1 GLI2 CD33 LTBP4 NOTCH3	3.39e-04	195	108	6	4549_UP
Drug	caffeine	CACNB1 PDE1A PDE3A PDE3B CYP2C19 GRIN2A RYR2 ITPR3 PKD1 PDE7B	3.44e-04	562	108	10	CID000002519
Drug	Lithocholic acid [434-13-9]; Up 200; 10.6uM; PC3; HT_HG-U133A	TCF4 ETV1 B3GNT3 PROZ PTPRN2 LTBP4	3.48e-04	196	108	6	4551_UP
Drug	Etodolac [41340-25-4]; Up 200; 14uM; MCF7; HT_HG-U133A	TCF4 CACNB1 DAPK1 NEUROD1 PTPRN2 SPAG16	3.48e-04	196	108	6	2254_UP
Drug	Lidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; PC3; HT_HG-U133A	ABCA3 KIAA0319L RYR2 ITPR3 PROZ LTBP4	3.48e-04	196	108	6	4596_UP
Drug	Piretanide [55837-27-9]; Down 200; 11uM; MCF7; HT_HG-U133A	FKBP10 KIAA0319L PHF8 DIS3 RYR2 NOTCH3	3.48e-04	196	108	6	3567_DN
Drug	Retinoic acid [302-79-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	FKBP10 TCF4 GALK1 B3GNT3 RYR2 SGSM2	3.48e-04	196	108	6	5767_DN
Drug	Epitiostanol [2363-58-8]; Down 200; 13uM; PC3; HT_HG-U133A	ACACB RYR2 CDC42EP1 SGSM2 NOTCH3 CPSF7	3.48e-04	196	108	6	4204_DN
Drug	Sulpiride [15676-16-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	CACNB1 ABCA3 B3GNT3 RYR2 NEUROD1 LMX1B	3.58e-04	197	108	6	4566_UP
Drug	STOCK1N-35874; Down 200; 14uM; PC3; HT_HG-U133A	HDHD3 B3GNT3 ZHX2 CDC42EP1 SPAG16 NOTCH3	3.58e-04	197	108	6	6561_DN
Drug	thioridazine hydrochloride; Up 200; 1uM; MCF7; HG-U133A	CDK8 ETV1 TLE3 ZNF638 CDK5RAP2 FUT8	3.58e-04	197	108	6	422_UP
Drug	Dubinidine [22964-77-8]; Up 200; 14.6uM; HL60; HT_HG-U133A	TCF4 CACNB1 CYP2C19 ACACB EFS ETV1	3.58e-04	197	108	6	6131_UP
Drug	Ajmalicine hydrochloride [4373-34-6]; Up 200; 10.2uM; MCF7; HT_HG-U133A	CACNB1 ACACB IL25 PDHA2 SYT17 KIAA0319L	3.58e-04	197	108	6	2898_UP
Drug	Naringin hydrate [11032-30-7]; Up 200; 6.6uM; MCF7; HT_HG-U133A	ABCA3 ACACB KIAA0319L ITPR3 SGSM2 MAP4K2	3.68e-04	198	108	6	3286_UP
Drug	troglitazone; Down 200; 10uM; MCF7; HT_HG-U133A_EA	CDK8 FOXJ2 ABCA3 ARID1A TLE3 NOTCH3	3.68e-04	198	108	6	1070_DN
Drug	Pizotifen malate [5189-11-7]; Up 200; 9.4uM; HL60; HT_HG-U133A	CACNB1 ACACB ETV1 GRIN2A B3GNT3 PTPRN2	3.68e-04	198	108	6	3134_UP
Drug	Solanine alpha [20562-02-1]; Up 200; 4.6uM; MCF7; HT_HG-U133A	CACNB1 PDHA2 KIAA0319L B3GNT3 NEUROD1 LTBP4	3.78e-04	199	108	6	2808_UP
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; HL60; HT_HG-U133A	ACACB PGGHG ETV1 RYR2 PTPRN2 LTBP4	3.78e-04	199	108	6	6153_UP
Drug	CP-320650-01 [172079-28-6]; Up 200; 10uM; PC3; HT_HG-U133A	CACNB1 PDHA2 KIAA0319L PROZ PTPRN2 NOTCH3	3.78e-04	199	108	6	3822_UP
Disease	age at menarche	TCF4 SIM1 ARID1A CCDC85A TNNI3K PTPRN2 NKX2-1 HACE1 RBM6 FUT8 PDE7B UNC80	1.27e-06	594	104	12	EFO_0004703
Disease	salicylurate measurement	SLAIN2 RYR2 ZNF638	1.19e-05	13	104	3	EFO_0010532
Disease	Autosomal dominant polycystic kidney disease	GANAB PKD1	3.68e-05	3	104	2	cv:C0085413
Disease	Seizures	CDK8 TCF4 TBCK HACE1 FUT8 NOTCH3	1.26e-04	218	104	6	C0036572
Disease	Respiratory Distress Syndrome, Newborn	ABCA3 NKX2-1	1.83e-04	6	104	2	C0035220
Disease	Polycystic kidney disease, type 2	GANAB PKD1	2.55e-04	7	104	2	C2751306
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	GANAB PKD1	3.40e-04	8	104	2	C0887850
Disease	Polycystic Kidney, Autosomal Dominant	GANAB PKD1	4.36e-04	9	104	2	C0085413
Disease	mental or behavioural disorder	DAPK1 SIM1 PHF8 PTPRN2 HACE1	4.40e-04	179	104	5	EFO_0000677
Disease	Colorectal Carcinoma	CACNB1 ABCA3 EFS PAIP2 ETV1 GRIN2A ARID1A TNNI3K PTPRN2	8.55e-04	702	104	9	C0009402
Disease	obesity (implicated_via_orthology)	TCF4 ETV1 SIM1 ITPR3 NOTCH3	1.00e-03	215	104	5	DOID:9970 (implicated_via_orthology)
Disease	response to carboplatin	PDE1A PDE3A GPR158	1.14e-03	58	104	3	GO_0097328
Disease	Hallux valgus	CDK8 GRIN2A HACE1	1.26e-03	60	104	3	HP_0001822
Disease	urate measurement, bone density	PDE3B ETV1 SIM1 PTPRN2 GLI2 TPH2 RBM6 CDH4	1.58e-03	619	104	8	EFO_0003923, EFO_0004531
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	TCF4 PDE1A NRAP GRIN2A RYR2 TNNI3K PTPRN2 SGSM2 HACE1	2.12e-03	801	104	9	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	Ovarian Failure, Premature	CYP2C19 HFM1	2.47e-03	21	104	2	C0085215
Disease	insulin measurement	GALNTL6 TCF4 PDE3A CCDC85A SGSM2	2.59e-03	267	104	5	EFO_0004467
Disease	Colorectal Neoplasms	ABCA3 PAIP2 ETV1 GRIN2A ARID1A	3.04e-03	277	104	5	C0009404
Disease	Rheumatoid Arthritis	GIN1 PXK TXNDC5 TLE3	3.40e-03	174	104	4	C0003873
Disease	type 1 diabetes mellitus (is_implicated_in)	ITPR3 NEUROD1 PTPRN2	3.41e-03	85	104	3	DOID:9744 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EMALHVAARYGHADV	DAPK1	446	P53355
FPGDVQNYHEIMTRH	C2orf69	106	Q8N8R5
ERATGEHASMHEYPG	CACNB1	456	Q02641
VSHTSDMHRGYADSP	CAP1	21	Q01518
EDEHQGMVHYHLPGR	ABCA3	1641	Q99758
ERMQQEFHGPTEHIY	CDK5RAP2	86	Q96SN8
AAYHMTAAGVPQLSH	NKX2-1	66	P43699
RMAAAEHRHSSGLPY	NPIPB3	216	Q92617
ERQPMYSREHGAAAS	RBM27	426	Q9P2N5
NGHSHEDDNPFAEYM	PAIP2	21	Q9BPZ3
MKASAPYNHHGSRDS	CPSF7	311	Q8N684
HMEPVVAAHVGDNYL	HDHD3	181	Q9BSH5
AARDGVEDHSPLMYH	ITPR3	1351	Q14573
RMAAAEHRHSSGLPY	NPIPB12	216	F8W0I5
GVDRHHLMAALSAYA	PTPRN2	236	Q92932
TYDMFPDTIHSRGQH	MAP4K2	306	Q12851
MHYNGVSHITVPDDF	ACACB	1986	O00763
PAYHGVNRTDEMLHT	ARID1A	1521	O14497
HRDYHNTSMALEGVP	ANKRD13A	96	Q8IZ07
TITNLRYEENMHHPG	MUC16	13486	Q8WXI7
RYEENMHHPGSRKFN	MUC16	13491	Q8WXI7
MKGAAHYHSLPAQDN	NRAP	341	Q86VF7
AFHEPRYMAVAVHNE	GPR158	606	Q5T848
HPRDYSGEMEGKHSQ	KIAA0319L	351	Q8IZA0
NAVVMGLAPEHFHYQ	HDHD2	111	Q9H0R4
EELHYASLNFHGMNP	CD33	336	P20138
PYDHMTSRDLGSHDN	TCF4	76	P15884
DPRAMAEKGYETGHH	LCTL	201	Q6UWM7
AMVFAAAIHDYEHTG	PDE1A	251	P54750
VAAAMHDYDHPGRTN	PDE3A	831	Q14432
VAAAMHDYDHPGRTN	PDE3B	816	Q13370
PYHNAVHAADVTQAM	PDE7B	171	Q9NP56
LGNHGYDNALADMHP	ENPP5	336	Q9UJA9
YDNALADMHPIFLAH	ENPP5	341	Q9UJA9
YHDPVYEHNTMVGSA	ETV1	231	P50549
APHAMRHIQEHYGGT	GALK1	361	P51570
FYEHLHSGQPDSDMV	HACE1	531	Q8IYU2
ADNPRHGSSEDYLHM	NIPBL	236	Q6KC79
RLDAHGQAMVFPYHR	NOTCH3	1546	Q9UM47
RMAAAEHRHSSGLPY	NPIPB5	216	A8MRT5
MRHQEGRYHYEPHSV	GLI2	66	P10070
SLALHGRSDHMSYPE	MEOX2	26	P50222
AGYPNEEGMFASQHH	MEOX2	51	P50222
HLRGVMSPDEYHSGV	PGGHG	421	Q32M88
TQDSAGYNRPAHHMV	FOXJ2	536	Q9P0K8
RMAAAEHRHSSGLPY	NPIPA3	216	F8WFD2
QENAMLYHHAEPLAA	PLEKHM3	586	Q6ZWE6
AMAHHGYLEQPGGEA	MROH1	416	Q8NDA8
RMAAAEHRHSSGLPY	NPIPB4	216	C9JG80
DGAAYHHAGMELSDR	HFM1	581	A2PYH4
RMAAAEHRHSSGLPY	NPIPB11	216	E5RHQ5
HCPRMVQDGDFVRYH	FKBP10	166	Q96AY3
DRGHMPYTDAVVHEV	CYP2C19	341	P33261
DGGHHYPEMDARQER	CDC42EP1	326	Q00587
ASYHLRAHAVDMNGN	CDH4	241	P55283
SPAGLHHRMAAELSY	CEP350	1321	Q5VT06
AGHHNEYEGIPMAEE	EFS	366	O43281
HTDNMVFYLQDHDPG	B3GNT3	216	Q9Y2A9
GSPHHRNVYSGMNES	CCDC85A	401	Q96PX6
VYTMPLANHRDDEHG	LTBP4	201	Q8N2S1
LYMVNGEGHASCDHR	EFNA2	91	O43921
VGSQDSYHHARGLEM	KHDC1	161	Q4VXA5
GSHMDPRGNSELLYH	IL25	121	Q9H293
GSMEHPARNVEAGAY	ERICH5	306	Q6P6B1
PYHHDQLDRIFNVMG	CDK8	246	P49336
DAAHGYSPRAIDMSN	RYR2	2816	Q92736
RMAAAEHRHSSGLPY	NPIPB9	231	F8W1W9
HDQPEMGSHYFAQAG	C14orf178	26	Q8N769
LVEHNVMHTYAAPGE	PKD1	1086	P98161
RMAAAEHRHSSGLPY	NPIPB13	216	A6NJU9
NPDAKDHYEATAMHR	PSMD10	131	O75832
DHYEATAMHRAAAKG	PSMD10	136	O75832
ELQTYRYHGHSMSDP	PDHA2	281	P29803
GTEAAFHPIEEYMVH	FUT8	371	Q9BYC5
HNHFGYEAQAGDAMR	GALNTL6	266	Q49A17
DYVREHHGNAMQPSV	PHYHIPL	196	Q96FC7
SMVEEGNPHHYFVAT	UTP23	106	Q9BRU9
PHMNYRDRDAHAVDF	RBM6	151	P78332
GPTVYDASHMGHARS	CARS1	56	P49589
DEDDNMHHAVYPAVN	SLAIN2	326	Q9P270
SHDGSRQDMAHSNPY	SYT17	216	Q9BSW7
HVGASRTPQEVMEHY	TADA2B	96	Q86TJ2
MGAYQPFFRAHAHLD	GANAB	666	Q14697
DLMGPFHTSNRSHVY	GIN1	146	Q9NXP7
IYPGHRHEHNAGDMI	SGSM2	421	O43147
REAYENSMPHIASVH	SIM1	506	P81133
LRRHPMDQSYHSADQ	SHROOM4	821	Q9ULL8
HVHVHMRYDADAGEN	PROZ	246	P22891
VHTAPAHGMEDYGVA	IARS2	391	Q9NSE4
AHGMEDYGVASQHNL	IARS2	396	Q9NSE4
SGMDNDFHHYGLASP	DIS3	756	Q9Y2L1
ELLPTDMRHHGSFNY	PVALEF	26	A0A1B0GWK0
SHPHYDEAGNVLNMG	BCO1	171	Q9HAY6
GGRMVQSYHPHSSDV	WDR47	831	O94967
AVPGYQHPSEAMNAH	USP19	971	O94966
NFRRHMITHTGDGPY	ZNF791	426	Q3KP31
PEGMSNAGAEENYHR	UNC80	1441	Q8N2C7
ADYLHLDVMDGHFVP	RPEL1	31	Q2QD12
AFGHHAYRMQAADVL	SLC27A1	271	Q6PCB7
ANHPVHYDTSADDDM	TBC1D8	396	O95759
LYGHMHSINDAIFDP	SPAG16	516	Q8N0X2
YGHLHASNVMLDGDT	PXK	286	Q7Z7A4
GLYHMTAHGDDVDFP	TBCK	136	Q8TEA7
HRVLMYGSELDADHP	TPH2	166	Q8IWU9
RMAAAEHRHSSGLPY	NPIPB2	231	A6NJ64
HHEMNGSLTSPGAYA	TLE3	376	Q04726
HQPMADDHGYDAVAR	ZHX2	696	Q9Y6X8
HPYDMGGQSFQHSVD	ZNF16	181	P17020
DGQDPHSKHLYTADM	TXNDC5	56	Q8NBS9
ADHEYTARPNAFGMA	PHF8	986	Q9UPP1
ADYLHLDVMDGHFVP	RPE	31	Q96AT9
AHLKPAAAAADMAYH	TNNI3K	666	Q59H18
AAAAADMAYHHIRPP	TNNI3K	671	Q59H18
YEHRDAAAALAAMNG	TIAL1	56	Q01085
GSSVTHPDHYQRFDM	ZP2	581	Q05996
IPHRFAGHESYQNMG	ZNF638	51	Q14966
HMNPYGNDSIFHDID	LMX1B	346	O60663
SRGHNDVYISEHVMP	GRIN2A	1416	Q12879
MHYPAATLAGAQSHG	NEUROD1	301	Q13562
HHDRGPMYEELNAFF	NEUROD2	366	Q15784