Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domainig

OBSCN LRIT1 NECTIN1

8.91e-04190193PF00047
DomainImmunoglobulin

OBSCN LRIT1 NECTIN1

8.91e-04190193IPR013151
DomainIGc2

OBSCN LRIT1 NECTIN1

1.64e-03235193SM00408
DomainIg_sub2

OBSCN LRIT1 NECTIN1

1.64e-03235193IPR003598
DomainIGv

OBSCN NECTIN1

2.60e-0375192SM00406
DomainCys-rich_flank_reg_C

SLIT2 LRIT1

3.72e-0390192IPR000483
DomainLRRCT

SLIT2 LRIT1

3.72e-0390192SM00082
DomainLRRNT

SLIT2 LRIT1

4.40e-0398192IPR000372
DomainLRRNT

SLIT2 LRIT1

4.40e-0398192SM00013
DomainMFS

SLCO4A1 MFSD6

5.31e-03108192PS50850
DomainMFS_dom

SLCO4A1 MFSD6

8.07e-03134192IPR020846
DomainIG

OBSCN LRIT1 NECTIN1

8.42e-03421193SM00409
DomainIg_sub

OBSCN LRIT1 NECTIN1

8.42e-03421193IPR003599
DomainAAA+_ATPase

DNAH7 ABCA7

9.26e-03144192IPR003593
DomainAAA

DNAH7 ABCA7

9.26e-03144192SM00382
Domainfn3

OBSCN LRIT1

1.16e-02162192PF00041
DomainIG_LIKE

OBSCN LRIT1 NECTIN1

1.28e-02491193PS50835
DomainLRR_8

SLIT2 LRIT1

1.29e-02171192PF13855
DomainIg-like_dom

OBSCN LRIT1 NECTIN1

1.36e-02503193IPR007110
DomainLeu-rich_rpt_typical-subtyp

SLIT2 LRIT1

1.37e-02177192IPR003591
DomainLRR_TYP

SLIT2 LRIT1

1.37e-02177192SM00369
DomainFN3

OBSCN LRIT1

1.49e-02185192SM00060
DomainIg_I-set

OBSCN LRIT1

1.57e-02190192IPR013098
DomainI-set

OBSCN LRIT1

1.57e-02190192PF07679
DomainFN3

OBSCN LRIT1

1.71e-02199192PS50853
DomainIg_V-set

OBSCN NECTIN1

1.71e-02199192IPR013106
DomainLRR

SLIT2 LRIT1

1.75e-02201192PS51450
DomainFN3_dom

OBSCN LRIT1

1.88e-02209192IPR003961
DomainLRR_1

SLIT2 LRIT1

2.05e-02219192PF00560
Pubmed

Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort.

BACE1 ABCA7

1.70e-06419234958020
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

SLC6A1 BACE1 SLCO4A1 ABCA7 DNAJC14

2.93e-0569719528298427
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

OBSCN LRIT1 NECTIN1

9.10e-0516219325826454
Pubmed

miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.

SLC6A1 SLIT2

1.30e-043119237816598
Pubmed

Maternal bile acid transporter deficiency promotes neonatal demise.

SLCO4A1 SLIT2

4.75e-045919226416771
CytobandEnsembl 112 genes in cytogenetic band chr2q32

DNAH7 MFSD6

9.47e-04110192chr2q32
CytobandEnsembl 112 genes in cytogenetic band chr10q23

LRIT1 HELLS

2.93e-03195192chr10q23
CytobandEnsembl 112 genes in cytogenetic band chr11q23

BACE1 NECTIN1

3.70e-03220192chr11q23
GeneFamilyFibronectin type III domain containing

OBSCN LRIT1

4.85e-03160122555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

OBSCN LRIT1

4.91e-03161122593
GeneFamilySolute carriers

SLC6A1 SLCO4A1

2.72e-02395122752
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Dendritic_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLIT2 CYB5D2 DNAJC14

5.82e-05180193710526abedc8e0f9ba19ad69220df4c9468ada8f
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN CYB5D2 NECTIN1

6.62e-05188193ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN CYB5D2 NECTIN1

6.62e-0518819340ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

OBSCN SLCO4A1 MFSD6

7.27e-0519419340842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH7 MFSD6 HELLS

7.27e-051941935dffa578149104dda33774361e9e77b227b5f1ce
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

OBSCN SLC6A1 SLIT2

7.96e-05200193c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

OBSCN DNAH7 DNAJC14

7.96e-052001936b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal|GW12 / Sample Type, Dataset, Time_group, and Cell type.

OBSCN DNAH7 DNAJC14

7.96e-05200193be83f442179ba4217d12f0458059586ff3130991
ComputationalGenes in the cancer module 379.

PTH2R LRIT1 TEX28 NECTIN1

5.53e-05204124MODULE_379
ComputationalGenes in the cancer module 242.

PTH2R LRIT1 TEX28 NECTIN1

6.67e-05214124MODULE_242
ComputationalGenes in the cancer module 181.

PTH2R LRIT1 TEX28 NECTIN1

2.66e-04306124MODULE_181
ComputationalGenes in the cancer module 104.

PTH2R LRIT1 TEX28 NECTIN1

4.59e-04353124MODULE_104
ComputationalGenes in the cancer module 41.

PTH2R LRIT1 TEX28 NECTIN1

2.68e-03566124MODULE_41
Diseaseschizophrenia (implicated_via_orthology)

SLC6A1 BACE1

6.96e-0468172DOID:5419 (implicated_via_orthology)
DiseaseAcute Confusional Senile Dementia

BACE1 ABCA7

1.47e-0399172C0546126
DiseasePresenile dementia

BACE1 ABCA7

1.47e-0399172C0011265
DiseaseAlzheimer's Disease, Focal Onset

BACE1 ABCA7

1.47e-0399172C0750900
DiseaseAlzheimer Disease, Early Onset

BACE1 ABCA7

1.47e-0399172C0750901
DiseaseAlzheimer Disease, Late Onset

BACE1 ABCA7

1.47e-0399172C0494463
DiseaseFamilial Alzheimer Disease (FAD)

BACE1 ABCA7

1.50e-03100172C0276496
DiseaseAlzheimer's Disease

BACE1 ABCA7

1.53e-03101172C0002395
Diseasetransient cerebral ischemia (biomarker_via_orthology)

BACE1 SLIT2

3.63e-03157172DOID:224 (biomarker_via_orthology)
Diseaseamino acid measurement

SLIT2 DNAH7 PTH2R

6.46e-03678173EFO_0005134
Diseaseaortic measurement

TMEM270 HELLS

9.01e-03251172EFO_0020865
Diseasethyroid stimulating hormone measurement

TMEM86B MFSD6

1.46e-02323172EFO_0004748
Diseaseserum metabolite measurement

TMEM86B SLIT2 ABCA7

1.59e-02945173EFO_0005653

Protein segments in the cluster

PeptideGeneStartEntry
MAQALPWLLLWMGAG

BACE1

1

P56817
MRAMGLSRAVLWLGW

ABCA7

581

Q8IZY2
MGVWTGRLGGWAQVM

DNAJC14

291

Q6Y2X3
MEWLRMLWENGINGI

HELLS

231

Q9NRZ9
MELWGRMLWALLSGP

HEMK1

1

Q9Y5R4
LQRMWGSLGWGLAML

MFSD6

326

Q6ZSS7
MRVALGMLWLLALAW

LRIT1

1

Q9P2V4
GGMLGQGPMWARIAW

OBSCN

7201

Q5VST9
MLGWRPLMLSWVNLL

DNAH7

1756

Q8WXX0
KWGQGVGWLMALSSM

SLC6A1

531

P30531
ADLWWMQGLLRNMAL

PNPLA5

371

Q7Z6Z6
MAARLMGWWGPRAGF

CYB5D2

21

Q8WUJ1
RWLGWGVLLMGTGSL

SLCO4A1

171

Q96BD0
VLQGPRLMWAGMWGS

TMEM270

91

Q6UE05
RLMWAGMWGSTKGLG

TMEM270

96

Q6UE05
MMITRGWEGWGRRGA

PRO2289

1

Q9P1D8
MRGVGWQMLSLSLGL

SLIT2

1

O94813
LILMAMLWRGLAQGG

TMEM86B

156

Q8N661
MAGLGASLHVWGWLM

PTH2R

1

P49190
MLMLIGLGVLAWQRW

TEX28

366

O15482
MARMGLAGAAGRWWG

NECTIN1

1

Q15223