Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontriplex DNA binding

DDX11L8 DDX11

1.02e-044832GO:0045142
Pubmed

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.

ERN1 BBC3

1.90e-05388222510886
Pubmed

The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.

PTPN11 ARHGAP33

1.90e-05388217664338
Pubmed

Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.

DDX11L8 DDX11

1.90e-05388217611414
Pubmed

Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor.

ERN1 BBC3

1.90e-05388234636989
Pubmed

Mammalian ChlR1 has a role in heterochromatin organization.

DDX11L8 DDX11

1.90e-05388221854770
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SLC6A8 RADIL SPIRE2 ARHGEF40 SLC2A4RG KIF26A PIEZO1 KANK3 TMEM132A ULK1 CEP170B ARHGAP33

2.22e-051105881235748872
Pubmed

HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation.

ING1 SMURF1

3.79e-05488220621832
Pubmed

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

SLC6A8 DLGAP3 MICU3 ING1 BAG4 ARHGAP9 GRIN3A PTGER1 RBM20 STAB1

4.88e-05832881036724073
Pubmed

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak.

ERN1 BBC3

6.30e-05588219339988
Pubmed

Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships.

ARHGAP9 ARHGAP33

6.30e-05588212297274
Pubmed

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.

ERN1 BBC3

1.32e-04788222773666
Pubmed

The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.

DDX11L8 DDX11

1.75e-04888222678773
Pubmed

FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium.

SFTPB FGF4

2.81e-04108829056643
Pubmed

SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes.

PTPN11 ACAN

3.43e-041188228983104
Pubmed

Identification of candidate proteins binding to prion protein.

DLGAP3 APLP1

4.11e-04128829173930
Pubmed

Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.

ACAN STAB1

4.11e-041288218296617
Pubmed

Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy.

ERN1 BBC3

4.85e-041388227130031
Pubmed

Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.

ACAN ADAMTS16

6.51e-041588238018454
Pubmed

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PHF1 ARHGAP33

8.40e-041788220873783
Pubmed

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.

PTPN11 FGF4

9.43e-041888215870281
Pubmed

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

SLC2A4RG PLCH2 INAVA

1.04e-037888321297633
Pubmed

Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.

ERN1 BBC3

1.55e-032388230655546
Pubmed

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.

ERN1 ULK1

1.98e-032688228474670
Pubmed

Analysis of a lung defect in autophagy-deficient mouse strains.

SFTPB ULK1

1.98e-032688224275123
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

PTPN11 ACAN

1.98e-032688233905568
Pubmed

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.

GDF7 FGF4

2.46e-032988221209331
Pubmed

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

ACAN TNS1

2.46e-032988221998595
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPIRE2 ACAN CCDC97 SLC4A9 NCCRP1

3.40e-06117875240cd636d1f5d3f270825ace02126fae993f5802
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ING1 CENPF ARHGAP9 STAB1

7.12e-0663874d8308a11cc01252b678f2e3247ee3a028221e04c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EXD3 DDN TSEN54 C1orf210 IL2RB

1.51e-05159875a710551512aa0b7a281a81bea651a43c9f3b3539
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPOAP1 ZC3H12D APLP1 IGSF9B IGFLR1

2.53e-05177875fd4a297e519b3959811a462d63feebff76429031
ToppCelldroplet-Lung-nan-21m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZC3H12D APLP1 IGSF9B IGFLR1 IL2RB

2.53e-051778758cc74873f4d2d0f81042426a687b01750abc72d2
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZC3H12D APLP1 IGSF9B IGFLR1 IL2RB

2.53e-05177875fe0f6a73264632bdd4f9fbc22de2d155ba2bcf8c
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPOAP1 ZC3H12D APLP1 IGSF9B IGFLR1

2.53e-05177875e995230ef207dcd87eab4550617589016ffa9970
ToppCellDendritic_Cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

CD1B ARHGAP9 IGFLR1 NCCRP1 STAB1

2.60e-051788753a28103cf282cc3637d1875a3b4cd7ddf3207687
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3|Hippocampus / BrainAtlas - Mouse McCarroll V32

ACAN INAVA SLC4A9 NCCRP1

2.94e-0590874a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr|Hippocampus / BrainAtlas - Mouse McCarroll V32

ACAN INAVA SLC4A9 NCCRP1

2.94e-0590874ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 PLEKHA4 SORCS3 IGSF9B SVIP

3.13e-0518587511c147f3f5570c4761d2bcff3bad28146b4a5861
ToppCellBAL-Control-Myeloid-MoAM-MoAM4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LSR ARHGEF40 NINJ1 TNS1 STAB1

3.13e-0518587529d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCellBAL-Control-Myeloid-MoAM-MoAM4-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LSR ARHGEF40 NINJ1 TNS1 STAB1

3.13e-05185875780bdb63ef913a09930063286011c9108381d3a9
ToppCellBAL-Control-Myeloid-MoAM-MoAM4|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

LSR ARHGEF40 NINJ1 TNS1 STAB1

3.13e-05185875274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCellBAL-Control-Myeloid-MoAM-MoAM4-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LSR ARHGEF40 NINJ1 TNS1 STAB1

3.13e-05185875b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCelldroplet-Fat-SCAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM132A C1orf210 HPDL RBM20 ARHGAP33

3.30e-051878755fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCelldroplet-Fat-SCAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM132A C1orf210 HPDL RBM20 ARHGAP33

3.30e-05187875766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCelldroplet-Fat-SCAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM132A C1orf210 HPDL RBM20 ARHGAP33

3.30e-05187875f49d06600060deeb2fc1b1da5b93496535f20104
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 PLEKHA4 SORCS3 IGSF9B SVIP

3.38e-05188875c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 PLEKHA4 SORCS3 IGSF9B SVIP

3.38e-051888753b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 BAG4 LNX1 TNS1 NCCRP1

3.65e-05191875297bc79adc5fef211497819b4861b52cd26ac754
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 BAG4 LNX1 TNS1 NCCRP1

3.65e-05191875e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCellControl-Myeloid-MoAM4|Control / Disease group,lineage and cell class （2021.01.30）

LSR ARHGEF40 NINJ1 TNS1 STAB1

3.74e-051928751da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCellSepsis-URO-Lymphocyte-T/NK-CD8+_T_naive|URO / Disease, condition lineage and cell class

LSR MICU3 KANK3 SVIP UBOX5

4.33e-05198875c07426d4119b53e58eb5f448ae364f47cac1fc5c
ToppCellSepsis-URO-Lymphocyte-T/NK-NK_CD56bright|URO / Disease, condition lineage and cell class

MICU3 PLCH2 PTGER1 IL2RB BBC3

4.54e-052008752fff822145ec298445595ba64334e6a1db8254f4
DrugAH23848 hemicalcium salt hydrate; Down 200; 1uM; MCF7; HT_HG-U133A

SETD2 ING1 TMEM132A SMURF1 PHLPP1 DIXDC1 BBC3

7.88e-061958476890_DN
DrugFluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; PC3; HT_HG-U133A

SLC6A8 EXD3 ING1 ACAN DDN TNS1 STAB1

8.42e-061978475741_UP
DiseaseWarsaw breakage syndrome (implicated_via_orthology)

DDX11L8 DDX11

2.51e-053862DOID:0060535 (implicated_via_orthology)
Diseaselymphocyte measurement

ERN1 PIEZO1 ULK1 RBM20

3.88e-04117864EFO_0803546
Diseaseacetate measurement

PTPN11 ACSS2

1.54e-0320862EFO_0010112
Diseasediaphragmatic hernia

PHF1 ADAMTS16

1.70e-0321862EFO_0008561
Diseasedescending aortic diameter

ARHGEF40 GDF7 LNX1

2.19e-0388863EFO_0021788
DiseaseL lactate dehydrogenase measurement

NINJ1 STAB1

2.61e-0326862EFO_0004808

Protein segments in the cluster

PeptideGeneStartEntry
RPGAGDDTRTWGPPF

SUGCT

81

Q9HAC7
AGQAWTPEPSPRRGG

UMODL1

601

Q5DID0
PPISWRVRGGGPAET

BAG4

46

O95429
ALGGSRWPGGPRSRP

BBC3

71

Q9BXH1
GSPAAGPPTRRGSWR

FAM246C

101

P0DSO1
GPPTRRGSWRSASGG

FAM246C

106

P0DSO1
PGPGGNESQWIRTRP

SLC4A9

571

Q96Q91
GGAQWGPRSPSPSLS

ARHGEF40

976

Q8TER5
RPGPGSQGPESATWK

CARMIL2

1276

Q6F5E8
SPLSRDWRPGSPGTY

DIXDC1

261

Q155Q3
RGSWGPGPSSLTVPA

ALPK3

1261

Q96L96
PSTRSWPPGSRVEGA

APLP1

226

P51693
GAGGRARSWSPPPEV

ACSS2

21

Q9NR19
GPTWSRGRRSPRAPG

CEP170B

776

Q9Y4F5
EAWLSSGPSPGPGRL

CD1B

206

P29016
GSAGTAPRRRWDRPP

DDN

211

O94850
RHPPFAAAGPSRGSW

ADAMTS16

1116

Q8TE57
PPGPSRADWGNGRDS

RBM20

661

Q5T481
SWTPGRGGEPSSAAP

TSPOAP1

26

O95153
EAWGTATVGRPRGPP

TSPOAP1

1526

O95153
PAPGSAAGWPRSDRR

KIRREL3-AS3

156

Q8N7Y1
WAQAPPGRQPSRGGS

RADIL

876

Q96JH8
ASGLPPARGSWRETG

EFCAB2

26

Q5VUJ9
PRTSGRGPPGRWVQV

NCCRP1

216

Q6ZVX7
GPGHWGELSRTPVPS

CCDC97

21

Q96F63
APGPGTGARAWPVLV

C1orf210

21

Q8IVY1
APWAGRGGAAAPTAP

FGF4

21

P08620
PPPASGPDSRRRWGA

PTGER1

241

P34995
TRPFPIPHGGDGTWR

NAT16

281

Q8N8M0
GSWSPGPGERSNTPK

LNX1

481

Q8TBB1
SRPGREPQAGPSRWA

KIF26A

1186

Q9ULI4
GPWGRPAVTTLGLPG

MICU3

26

Q86XE3
RGVTATFGRPAEWPG

PNPO

6

Q9NVS9
RTWPDHGVPSDPGGV

PTPN11

421

Q06124
AAGTPRPAGEPAWVT

DDX11

101

Q96FC9
WPGTIQREGSSPRPG

FAM170B

36

A6NMN3
TDRSEGLSPWPRSPG

LRRC66

796

Q68CR7
TGEATRPWGFPTPGL

ACAN

436

P16112
FRPVSSAPGPGWVSR

HPDL

146

Q96IR7
PGTPGSPDASPARWG

NINJ1

16

Q92982
RRSPAPSPGARWLGS

GRIN3A

86

Q8TCU5
EPTAPGPSRRSWSAG

PRICKLE3

371

O43900
GPSRRSWSAGPVTAP

PRICKLE3

376

O43900
WLGGTRAPPQPSGSR

ARHGAP33

611

O14559
SGIWENGRGPTPATP

CENPF

2936

P49454
SRRSGVPGTEGWIAP

ERN1

726

O75460
GAGRGHPTPTPRVRW

TMEM132E-DT

66

A2RUQ5
AAGTPRPAGEPAWVT

DDX11L8

101

A8MPP1
APTPGPGAGRRDSWI

DLGAP3

761

O95886
AVTPTPAAGGGRTPW

IGFLR1

96

Q9H665
PDAGPREGVSFPWSR

IL2RB

501

P14784
REGVSFPWSRPPGQG

IL2RB

506

P14784
GEGSGSPVRPPVSTW

C20orf141

26

Q9NUB4
PRPGLAGARSPGAWT

KANK3

76

Q6NY19
PEEAALGWSPRPSGG

CCDC201

36

A0A1B0GTI1
GSSRLPTQPGPGWSR

INAVA

56

Q3KP66
GGHSPRSPRGWDQEP

LSR

461

Q86X29
GPGEAGPTRRTWASP

PCARE

866

A6NGG8
PRAPAPGEGEGTSWV

PHF1

121

O43189
WRPGTGSEQPGSILG

UBOX5

466

O94941
WPRGGRNGPPTRRSD

SRSF9

96

Q13242
PSPGPAREGVGCSWE

TSEN54

266

Q7Z6J9
DSAGPRSPTGEWLPR

SFTPB

281

P07988
AGRTTAAPRGPYGPW

TMEM132A

6

Q24JP5
TWDATGGPGRPAAPA

SORCS3

36

Q9UPU3
SSPRSPETDWGRPPG

PLEKHA4

531

Q9H4M7
LSPTSPFREGRPGEW

PROSER2

211

Q86WR7
GSRGAGRVSRWPPPH

ING1

101

Q9UK53
VLRRGSPESGPGSWT

GDF7

161

Q7Z4P5
RGTGQPGSRPTWPSQ

SHROOM1

526

Q2M3G4
GTPGGRLAVPPRETW

SLC6A8

41

P48029
PGRGPGPEWTSRSLL

RUSC1-AS1

21

Q66K80
IATSGPPPEGGLRWT

SVIP

61

Q8NHG7
GPLPPGWEVRSTVSG

SMURF1

306

Q9HCE7
TLPGPSWVRGSGPSV

ALKBH7

11

Q9BT30
PRTWTGAAAGPRTPS

SLC2A4RG

71

Q9NR83
PTGGRSPEPWGRPEF

IGSF9B

1031

Q9UPX0
SEGQVPTEPLGGWRP

PLCH2

1096

O75038
GTEPPRPRAGSAHVW

SPIRE2

466

Q8WWL2
APGTRPGWSPAVSGS

SYT15B

21

X6R8R1
GTNTPPSPGFGWRAI

TNS1

1186

Q9HBL0
GPWRPGRQRGAGTAP

SCAND2P

236

Q9GZW5
TGLRWQAPSGTPGDP

STAB1

491

Q9NY15
TAPSSGWGPAGSRPE

ARHGAP9

366

Q9BRR9
GPGRGPQRGSWVAPA

PYCARD-AS1

166

I3L0S3
WDPRSGRPPGTGVVY

SETD2

1306

Q9BYW2
PDWVSAGGRVPGPLS

ZC3H12D

376

A2A288
PPAWGQAPSPRRSVG

nan

186

Q8N9P0
VGGPGGWSRRASPAP

PHLPP1

306

O60346
SPGGSSPPRRQWWRP

PIEZO1

1391

Q92508
PQVGTIPERPGWSGT

ULK1

506

O75385
AAEGPGSWSPTARPG

TMED8

6

Q6PL24
SWWPPSGVVRGGPSS

nan

101

Q6ZSA8
SGVVRGGPSSWPPSG

nan

106

Q6ZSA8
GGPSSWPPSGVAEPR

nan

111

Q6ZSA8
EWTPVFVAGGRPRPS

EXD3

401

Q8N9H8
GSPGPGPARTTAVWR

NEXN-AS1

121

Q8NBZ9
GPARTTAVWRPAPSG

NEXN-AS1

126

Q8NBZ9