Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptidase activity	TPP2 CAPN1 XPNPEP1 PRSS23 ST14 MYSM1 ADGRG6 CFLAR USP2 HPR PAPPA ADAM2 CTSL ENPEP	9.34e-06	654	106	14	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	TPP2 CAPN1 PRSS23 ST14 ADGRG6 CFLAR USP2 HPR PAPPA ADAM2 CTSL	1.80e-05	430	106	11	GO:0004175
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	1.83e-05	103	106	6	GO:0004725
GeneOntologyMolecularFunction	cyclin binding	CDK15 USP2 CDK13 CDK3	3.46e-05	35	106	4	GO:0030332
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate phosphatase activity	PIKFYVE MTMR6 MTMR7	7.74e-05	16	106	3	GO:0106018
GeneOntologyMolecularFunction	aminopeptidase activity	TPP2 XPNPEP1 CTSL ENPEP	7.89e-05	43	106	4	GO:0004177
GeneOntologyMolecularFunction	phosphatase activity	PTPN22 PIKFYVE MTMR6 MTMR7 PTPRD PTPRF PTPRS ALPI	1.47e-04	287	106	8	GO:0016791
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PON3 PTPN22 PIKFYVE MTMR6 MTMR7 PTPRD PTPRF PTPRS ALPI	2.16e-04	386	106	9	GO:0042578
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ERCC4 POLD1 PON3 PTPN22 PIKFYVE DNASE2B MTMR6 MTMR7 PTPRD PTPRF PTPRS INTS11 ALPI	3.46e-04	807	106	13	GO:0016788
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	PIKFYVE MTMR6 MTMR7	3.88e-04	27	106	3	GO:0034593
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K3 MAP4K5	4.13e-04	6	106	2	GO:0008349
GeneOntologyMolecularFunction	phosphoprotein phosphatase activity	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	5.17e-04	189	106	6	GO:0004721
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	PIKFYVE MTMR6 MTMR7	5.32e-04	30	106	3	GO:0052866
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activity	CDK15 CDK13 CDK3	5.32e-04	30	106	3	GO:0004693
GeneOntologyMolecularFunction	cyclin-dependent protein kinase activity	CDK15 CDK13 CDK3	5.32e-04	30	106	3	GO:0097472
GeneOntologyMolecularFunction	protein serine kinase activity	CAMKK1 RIPK1 CDK15 MAP4K3 PIKFYVE CDK13 MAP4K5 CDK3	7.09e-04	363	106	8	GO:0106310
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	CAPN1 CFLAR USP2 CTSL	1.14e-03	86	106	4	GO:0004197
GeneOntologyMolecularFunction	protein kinase activity	CAMKK1 RIPK1 CDK15 MAP4K3 NRP2 PIKFYVE GUCY2C CDK13 MAP4K5 CDK3	1.34e-03	600	106	10	GO:0004672
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	MTMR6 MTMR7	1.49e-03	11	106	2	GO:0052629
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate phosphatase activity	MTMR6 MTMR7	2.44e-03	14	106	2	GO:0004438
GeneOntologyMolecularFunction	kinase activity	CAMKK1 RIPK1 CDK15 MAP4K3 NRP2 PIKFYVE PALS1 GUCY2C CDK13 MAP4K5 CDK3	2.45e-03	764	106	11	GO:0016301
GeneOntologyMolecularFunction	proteoglycan binding	PTPRF PTPRS CTSL	2.52e-03	51	106	3	GO:0043394
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CAMKK1 RIPK1 CDK15 MAP4K3 PIKFYVE CDK13 MAP4K5 CDK3	2.60e-03	446	106	8	GO:0004674
GeneOntologyMolecularFunction	phosphatidylinositol monophosphate phosphatase activity	MTMR6 MTMR7	2.80e-03	15	106	2	GO:0052744
GeneOntologyMolecularFunction	exopeptidase activity	TPP2 XPNPEP1 CTSL ENPEP	2.81e-03	110	106	4	GO:0008238
Domain	PTPc_motif	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	9.67e-07	59	105	6	SM00404
Domain	Tyr_Pase_cat	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	9.67e-07	59	105	6	IPR003595
Domain	Tyr_Pase_AS	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	3.43e-06	73	105	6	IPR016130
Domain	TYR_PHOSPHATASE_1	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	8.93e-06	86	105	6	PS00383
Domain	TYR_PHOSPHATASE_dom	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	9.55e-06	87	105	6	IPR000387
Domain	TYR_PHOSPHATASE_2	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	9.55e-06	87	105	6	PS50056
Domain	-	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	1.32e-05	92	105	6	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	PTPN22 MTMR6 MTMR7 PTPRD PTPRF PTPRS	2.01e-05	99	105	6	IPR029021
Domain	SLIDE	SMARCA5 SMARCA1	3.13e-05	2	105	2	IPR015195
Domain	ISWI_HAND-dom	SMARCA5 SMARCA1	3.13e-05	2	105	2	IPR015194
Domain	SLIDE	SMARCA5 SMARCA1	3.13e-05	2	105	2	PF09111
Domain	HAND	SMARCA5 SMARCA1	3.13e-05	2	105	2	PF09110
Domain	ISWI	SMARCA5 SMARCA1	3.13e-05	2	105	2	IPR029915
Domain	PTPc	PTPN22 PTPRD PTPRF PTPRS	4.84e-05	36	105	4	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPN22 PTPRD PTPRF PTPRS	6.67e-05	39	105	4	PS50055
Domain	PTPase_domain	PTPN22 PTPRD PTPRF PTPRS	8.14e-05	41	105	4	IPR000242
Domain	Y_phosphatase	PTPN22 PTPRD PTPRF PTPRS	8.14e-05	41	105	4	PF00102
Domain	DBINO	SMARCA5 SMARCA1	9.36e-05	3	105	2	IPR020838
Domain	DBINO	SMARCA5 SMARCA1	9.36e-05	3	105	2	PF13892
Domain	CUB	ST14 ADGRG6 NRP2 CSMD1	1.64e-04	49	105	4	PF00431
Domain	SANT	SMARCA5 TTF1 MYSM1 SMARCA1	1.78e-04	50	105	4	SM00717
Domain	CUB	ST14 ADGRG6 NRP2 CSMD1	1.78e-04	50	105	4	SM00042
Domain	MAPKKKK	MAP4K3 MAP4K5	1.86e-04	4	105	2	IPR021160
Domain	-	ST14 ADGRG6 NRP2 CSMD1	2.07e-04	52	105	4	2.60.120.290
Domain	SANT/Myb	SMARCA5 TTF1 MYSM1 SMARCA1	2.07e-04	52	105	4	IPR001005
Domain	CUB	ST14 ADGRG6 NRP2 CSMD1	2.23e-04	53	105	4	PS01180
Domain	CUB_dom	ST14 ADGRG6 NRP2 CSMD1	2.96e-04	57	105	4	IPR000859
Domain	SANT_dom	SMARCA5 MYSM1 SMARCA1	4.09e-04	26	105	3	IPR017884
Domain	PbH1	PKHD1L1 FBXO10	4.63e-04	6	105	2	SM00710
Domain	HELP	EML6 EML2	4.63e-04	6	105	2	PF03451
Domain	HELP	EML6 EML2	4.63e-04	6	105	2	IPR005108
Domain	PbH1	PKHD1L1 FBXO10	4.63e-04	6	105	2	IPR006626
Domain	SANT	SMARCA5 MYSM1 SMARCA1	5.11e-04	28	105	3	PS51293
Domain	Pectin_lyase_fold/virulence	PKHD1L1 FBXO10	8.57e-04	8	105	2	IPR011050
Domain	Myb_DNA-binding	SMARCA5 TTF1 MYSM1	9.91e-04	35	105	3	PF00249
Domain	RuvA_2-like	ERCC4 SUPT6H	1.10e-03	9	105	2	IPR010994
Domain	MYB_LIKE	SMARCA5 TTF1 MYSM1	1.26e-03	38	105	3	PS50090
Domain	Pkinase	CAMKK1 RIPK1 CDK15 MAP4K3 GUCY2C CDK13 MAP4K5 CDK3	1.39e-03	381	105	8	PF00069
Domain	fn3	CHL1 PTPRD PTPRF PTPRS SDK1	2.22e-03	162	105	5	PF00041
Domain	Myotubularin-like_Pase_dom	MTMR6 MTMR7	2.73e-03	14	105	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR6 MTMR7	2.73e-03	14	105	2	PS51339
Domain	Myotubularin_fam	MTMR6 MTMR7	2.73e-03	14	105	2	IPR030564
Domain	Myotub-related	MTMR6 MTMR7	2.73e-03	14	105	2	PF06602
Domain	CNH	MAP4K3 MAP4K5	2.73e-03	14	105	2	SM00036
Domain	CNH	MAP4K3 MAP4K5	3.13e-03	15	105	2	PF00780
Domain	CNH	MAP4K3 MAP4K5	3.13e-03	15	105	2	PS50219
Domain	CNH_dom	MAP4K3 MAP4K5	3.13e-03	15	105	2	IPR001180
Domain	Quinoprotein_ADH-like_supfam	EML6 EML2 WDR1	3.30e-03	53	105	3	IPR011047
Domain	SUSHI	HPR PAPPA CSMD1	3.86e-03	56	105	3	PS50923
Domain	FN3	CHL1 PTPRD PTPRF PTPRS SDK1	3.93e-03	185	105	5	SM00060
Domain	Ser/Thr_kinase_AS	CAMKK1 RIPK1 CDK15 MAP4K3 CDK13 MAP4K5 CDK3	4.04e-03	357	105	7	IPR008271
Domain	Sushi_SCR_CCP_dom	HPR PAPPA CSMD1	4.05e-03	57	105	3	IPR000436
Domain	S_TKc	CAMKK1 RIPK1 CDK15 MAP4K3 CDK13 MAP4K5 CDK3	4.16e-03	359	105	7	SM00220
Domain	PROTEIN_KINASE_ST	CAMKK1 RIPK1 CDK15 MAP4K3 CDK13 MAP4K5 CDK3	4.35e-03	362	105	7	PS00108
Domain	Ig_I-set	CHL1 PTPRD PTPRF PTPRS SDK1	4.39e-03	190	105	5	IPR013098
Domain	I-set	CHL1 PTPRD PTPRF PTPRS SDK1	4.39e-03	190	105	5	PF07679
Domain	FN3	CHL1 PTPRD PTPRF PTPRS SDK1	5.34e-03	199	105	5	PS50853
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TPP2 SMARCA5 PDHB POLD1 CAPN1 PSMC2 HNRNPD STXBP1 SEC24C PRIM2 INTS11 SMARCA1 WDR1 EIF2A FHL3	4.00e-09	704	106	15	29955894
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNB SMARCA5 PDHB MAP4K3 POLD1 CAPN1 PSMC2 EPB41L5 HNRNPD SEC24C PABPN1 MAP4K5 RPTOR PRIM2 INTS11 SMARCA1 CSTA WDR1 EIF2A	2.56e-08	1353	106	19	29467282
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRF PTPRS	2.75e-08	3	106	3	31985401
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRF PTPRS	2.75e-08	3	106	3	20139422
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRF PTPRS	2.75e-08	3	106	3	33656439
Pubmed	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.	PTPRD PTPRF PTPRS	2.75e-08	3	106	3	9784606
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	CHL1 PON3 ADGRG6 PTPRF PIGR PTPRS C5 CTSL ENPEP	1.00e-07	257	106	9	16335952
Pubmed	The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.	PTPRD PTPRF PTPRS	1.10e-07	4	106	3	8524829
Pubmed	Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.	PTPRD PTPRF PTPRS	2.74e-07	5	106	3	10777529
Pubmed	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.	PTPRD PTPRF PTPRS	2.74e-07	5	106	3	22357843
Pubmed	Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.	PTPRD PTPRF PTPRS	5.47e-07	6	106	3	19273906
Pubmed	Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.	PTPRD PTPRF PTPRS	9.55e-07	7	106	3	12376545
Pubmed	Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.	PTPRD PTPRF PTPRS	9.55e-07	7	106	3	29073098
Pubmed	Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.	PTPRD PTPRF PTPRS	1.52e-06	8	106	3	37591863
Pubmed	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.	PTPRD PTPRF PTPRS	1.52e-06	8	106	3	28637841
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FLNB PDHB POLD1 PSMC2 EPB41L5 LSR MTMR6 MTMR7 PTPRD PTPRF PTPRS WDR1 EIF2A FHL3	1.61e-06	974	106	14	28675297
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	TPP2 FLNB SMARCA5 CARS1 EPB41L5 HNRNPD CRIP2 SEC24C CDK13 EIF2A	3.09e-06	498	106	10	36634849
Pubmed	PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.	PTPRD PTPRF PTPRS	4.46e-06	11	106	3	25624497
Pubmed	A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.	PTPRD PTPRF PTPRS	4.46e-06	11	106	3	7832766
Pubmed	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.	PTPRD PTPRF PTPRS	5.93e-06	12	106	3	9624153
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FLNB EML6 TTC3 ST14 MYSM1 SHOC1 WDR1 CTSL	8.49e-06	332	106	8	37433992
Pubmed	RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival.	RIPK1 CFLAR	9.20e-06	2	106	2	26195820
Pubmed	Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.	A1CF RPTOR	9.20e-06	2	106	2	21357822
Pubmed	Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide.	CSTA CTSL	9.20e-06	2	106	2	12921779
Pubmed	The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.	PTPRD PTPRF	9.20e-06	2	106	2	7665159
Pubmed	Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.	A1CF RYR2	9.20e-06	2	106	2	22869620
Pubmed	Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing.	FLG ST14	9.20e-06	2	106	2	18843291
Pubmed	Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo.	A1CF RYR2	9.20e-06	2	106	2	23678000
Pubmed	Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.	A1CF RYR2	9.20e-06	2	106	2	24743769
Pubmed	The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma.	PTPRD PTPRS	9.20e-06	2	106	2	9566880
Pubmed	Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.	A1CF RYR2	9.20e-06	2	106	2	27621312
Pubmed	Functional proteomics mapping of a human signaling pathway.	FLNB PSMC2 TTC3 TTF1 RYR2 PTPRF TENM3 CDK13 PAPPA SDK1	1.38e-05	591	106	10	15231748
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MAP4K3 CAPN1 CARS1 DNASE2B MTMR6 MTMR7 ACSM3 CDK13 ADAM2 ATP6V0A2 CDK3	1.48e-05	730	106	11	34857952
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPRD PTPRF PTPRS	1.81e-05	17	106	3	19727691
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	GJC1 EPB41L5 NRP2 DIP2A STXBP1 PTPRF PTPRS MAP4K5	2.12e-05	377	106	8	38117590
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	CHL1 FLNB CAPN1 XPNPEP1 ITFG1 PALS1 PTPRD PIGR PTPRS HPR C5 CTSL ENPEP	2.33e-05	1070	106	13	23533145
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	FLG FLNB PSMC2 TTF1 VPS13D SUPT6H PCDH11X	2.35e-05	277	106	7	30745168
Pubmed	Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.	SMARCA5 DNASE2B SMARCA1	2.57e-05	19	106	3	27246713
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	STON1 EPB41L5 PKHD1L1 RYR2 DNASE2B LSR SEC24C TENM3 CLEC16A SDK1 ATP6V0A2	2.61e-05	777	106	11	35844135
Pubmed	Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.	VPS13D CSMD1	2.76e-05	3	106	2	20610895
Pubmed	The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L.	CSTA CTSL	2.76e-05	3	106	2	9585570
Pubmed	RIP-1/c-FLIPL Induce Hepatic Cancer Cell Apoptosis Through Regulating Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).	RIPK1 CFLAR	2.76e-05	3	106	2	28270653
Pubmed	Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells.	RIPK1 CFLAR	2.76e-05	3	106	2	17638906
Pubmed	The C-terminal domain of the long form of cellular FLICE-inhibitory protein (c-FLIPL) inhibits the interaction of the caspase 8 prodomain with the receptor-interacting protein 1 (RIP1) death domain and regulates caspase 8-dependent nuclear factor κB (NF-κB) activation.	RIPK1 CFLAR	2.76e-05	3	106	2	24398693
Pubmed	Binding kinetics of human ISWI chromatin-remodelers to DNA repair sites elucidate their target location mechanism.	SMARCA5 SMARCA1	2.76e-05	3	106	2	21738833
Pubmed	Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.	MTMR6 MTMR7	2.76e-05	3	106	2	12890864
Pubmed	Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l.	SMARCA5 SMARCA1	2.76e-05	3	106	2	11359880
Pubmed	Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway.	PTPRD PTPRF	2.76e-05	3	106	2	25703008
Pubmed	De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1.	RIPK1 USP2	2.76e-05	3	106	2	22659130
Pubmed	Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.	PTPRD PTPRS	2.76e-05	3	106	2	25394468
Pubmed	Human leukocyte antigen (DR1)-DQB10501 and (DR15)-DQB10602 haplotypes are associated with humoral responses to early food allergens in children.	FLG PTPN22	2.76e-05	3	106	2	20016199
Pubmed	The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.	RIPK1 CFLAR	2.76e-05	3	106	2	12215447
Pubmed	NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines.	SMARCA5 TTF1	2.76e-05	3	106	2	11532953
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	TPP2 FLNB SMARCA5 PDHB PSMC2 BCOR STXBP1 CDK13 SMARCA1 TUBAL3	3.75e-05	665	106	10	30457570
Pubmed	ABCE1 is a highly conserved RNA silencing suppressor.	FLNB SMARCA5 ISYNA1 PSMC2 PTPRF WDR1	3.96e-05	204	106	6	25659154
Pubmed	Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.	PIKFYVE CTSL	5.50e-05	4	106	2	32221306
Pubmed	Dynamic changes in the expression of protein tyrosine phosphatases during preimplantation mouse development: semi-quantification by real-time PCR.	PTPRF PTPRS	5.50e-05	4	106	2	14967925
Pubmed	FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity.	A1CF KLB	5.50e-05	4	106	2	36134579
Pubmed	Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.	PTPRF PTPRS	5.50e-05	4	106	2	26231120
Pubmed	Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis.	CAPN1 CTSL	5.50e-05	4	106	2	21880013
Pubmed	Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis.	PTPN22 C5	5.50e-05	4	106	2	20822712
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	FLNB SMARCA5 MAP4K3 CAPN1 HNRNPD CSTA WDR1	6.70e-05	327	106	7	31409639
Pubmed	Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.	PTPRD PTPRF PTPRS	6.80e-05	26	106	3	36178190
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	PDHB MAP4K3 EPB41L5 ITFG1 PALS1 ACSM3 TENM3 HEBP1 PRIM2 CEP152	7.18e-05	719	106	10	35337019
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	FLNB PDHB PSMC2 HNRNPD PALS1 WDR1 TUBAL3	7.64e-05	334	106	7	30425250
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TPP2 PDHB PSMC2 PTPN22 BCOR MTMR6 MTMR7 PTPRD PTPRF PTPRS PRIM2 INTS11	8.68e-05	1049	106	12	27880917
Pubmed	High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice.	NRP2 CFLAR	9.15e-05	5	106	2	16783640
Pubmed	Functional heterogeneity of POMC neurons relies on mTORC1 signaling.	RPTOR CNR1	9.15e-05	5	106	2	34644574
Pubmed	Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.	A1CF RYR2	9.15e-05	5	106	2	25193470
Pubmed	Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.	POLD1 PRIM2	9.15e-05	5	106	2	12220650
Pubmed	TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.	PTPN22 C5	9.15e-05	5	106	2	17804836
Pubmed	Proteasome inhibition blocks necroptosis by attenuating death complex aggregation.	RIPK1 CFLAR	9.15e-05	5	106	2	29497034
Pubmed	Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10.	SLC5A4 DIP2A	9.15e-05	5	106	2	11042146
Pubmed	Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.	PTPN22 C5	9.15e-05	5	106	2	19741008
Pubmed	Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.	SMARCA5 TTF1	9.15e-05	5	106	2	19578370
Pubmed	Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.	PTPN22 C5	9.15e-05	5	106	2	19180477
Pubmed	FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis.	RIPK1 CFLAR	9.15e-05	5	106	2	26972597
Pubmed	LRP6 acts as a scaffold protein in cardiac gap junction assembly.	A1CF GJC1	9.15e-05	5	106	2	27250245
Pubmed	The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.	RIPK1 CFLAR	9.15e-05	5	106	2	21737329
Pubmed	Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP).	RIPK1 CFLAR	9.15e-05	5	106	2	26865630
Pubmed	Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.	STXBP1 CNR1	1.37e-04	6	106	2	27056679
Pubmed	The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways.	RIPK1 CFLAR	1.37e-04	6	106	2	10837247
Pubmed	ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection.	USP2 WDR1	1.37e-04	6	106	2	31477895
Pubmed	WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.	SMARCA5 SMARCA1	1.37e-04	6	106	2	11980720
Pubmed	Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons.	PTPRD PTPRS	1.37e-04	6	106	2	38388459
Pubmed	Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta.	PTPRD PTPRS	1.37e-04	6	106	2	16738228
Pubmed	Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.	A1CF RYR2	1.37e-04	6	106	2	23540699
Pubmed	Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.	CAPN1 PALS1	1.37e-04	6	106	2	16737952
Pubmed	Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.	RIPK1 CFLAR	1.37e-04	6	106	2	21368763
Pubmed	Receptor protein tyrosine phosphatases are novel components of a polycystin complex.	PTPRD PTPRS	1.37e-04	6	106	2	21126580
Pubmed	Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.	RPTOR CNR1	1.37e-04	6	106	2	35379807
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	CHL1 LSR PTPRD PTPRF PTPRS	1.43e-04	162	106	5	25826454
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FLNB SMARCA5 PDHB POLD1 PSMC2 HNRNPD SEC24C SUPT6H PRIM2	1.50e-04	638	106	9	33239621
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	FLNB SMARCA5 ERCC4 PDHB HNRNPD PIGR PABPN1 CSTA ALDH3A1	1.77e-04	652	106	9	31180492
Pubmed	A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.	PTPN22 CLEC16A	1.91e-04	7	106	2	17632545
Pubmed	Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling.	A1CF RIPK1	1.91e-04	7	106	2	25278099
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	CAPN1 RYR2	1.91e-04	7	106	2	20962236
Pubmed	Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.	PTPN22 C5	1.91e-04	7	106	2	20353580
Pubmed	Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain.	PTPRF PTPRS	1.91e-04	7	106	2	1454056
Pubmed	De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.	RIPK1 USP2	1.91e-04	7	106	2	22179575
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	SMARCA5 TTF1 MYSM1 SMARCA1	1.02e-04	53	83	4	532
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRF PTPRS	1.17e-04	21	83	3	813
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K3 MAP4K5	2.06e-04	5	83	2	655
GeneFamily	Cyclin dependent kinases	CDK15 CDK13 CDK3	2.25e-04	26	83	3	496
GeneFamily	Fibronectin type III domain containing	CHL1 PTPRD PTPRF PTPRS SDK1	8.49e-04	160	83	5	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CHL1 PTPRD PTPRF PTPRS SDK1	8.73e-04	161	83	5	593
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR6 MTMR7	2.10e-03	15	83	2	903
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	HPR PAPPA CSMD1	2.28e-03	57	83	3	1179
GeneFamily	LIM domain containing	NRAP CRIP2 FHL3	2.52e-03	59	83	3	1218
GeneFamily	Aminopeptidases\|CD molecules	XPNPEP1 ENPEP	2.71e-03	17	83	2	104
GeneFamily	Phosphoinositide phosphatases	MTMR6 MTMR7	9.45e-03	32	83	2	1079
Coexpression	FIGUEROA_AML_METHYLATION_CLUSTER_5_UP	ADGRG6 NRP2 PABPN1	1.38e-05	12	106	3	M2172
Coexpression	BRUECKNER_TARGETS_OF_MIRLET7A3_DN	FLNB PRSS23 NRP2 PTPRF CTSL	1.45e-05	76	106	5	M11825
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHL1 PRSS23 ST14 CRIP2 NRP2 LSR PIGR	3.30e-07	187	106	7	82bbc107f58c623f3b90430c90c562624a12abef
ToppCell	ASK452-Epithelial-Transformed_epithelium\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	ISYNA1 PKHD1L1 RYR2 ADGRG6 PTPRF PIGR SMARCA1	4.69e-07	197	106	7	b22a79a5922c865a360e2afc5506a08a512fa76a
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHL1 CAPN1 PRSS23 PTPRF CSTA ALDH3A1 SDK1	4.85e-07	198	106	7	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHL1 CAPN1 PRSS23 ST14 PTPRF CSTA ALDH3A1	4.85e-07	198	106	7	3cc9e671f596ef0829684018e4257571fefb6267
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	ABCA10 RYR2 PTPRD TENM3 PTPRS PAPPA SDK1	4.85e-07	198	106	7	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	Goblet_3\|World / shred by cell class for nasal brushing	PDHB PON3 PRSS23 LSR PIGR ALDH3A1 CTSL	5.01e-07	199	106	7	4229a17a3a6d8855655acc0a1c8704166f8e74c0
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CHL1 POLD1 RYR2 PTPRD TENM3 PAPPA SDK1	5.01e-07	199	106	7	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA10 RYR2 TENM3 PTPRS PAPPA ENPEP SDK1	5.19e-07	200	106	7	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ISYNA1 GJC1 RYR2 RGS6 PAPPA CNR1	2.80e-06	165	106	6	8a82e20c9b1156bb4bbc16f7785abb04458d671b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PKHD1L1 ST14 NRP2 DNASE2B CSTA CTSL	3.93e-06	175	106	6	dc7721794162dee96944f4b4b87b5681bb02ea8f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 RYR2 PTPRD PCDH11X CSMD1 SDK1	5.24e-06	184	106	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 RYR2 PTPRD PCDH11X CSMD1 SDK1	5.24e-06	184	106	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 RYR2 PTPRD PCDH11X CSMD1 SDK1	5.24e-06	184	106	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PRSS23 RYR2 TENM3 PCDH11X PAPPA CSMD1	5.41e-06	185	106	6	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHIT1 NRP2 DNASE2B CSTA CTSL CNGB1	5.93e-06	188	106	6	fcf1bebef7aa81b4a11c1f9e4319339c290ecd22
ToppCell	5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 PKHD1L1 CRIP2 NRP2 NALCN FHL3	5.93e-06	188	106	6	524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell	5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 PKHD1L1 CRIP2 NRP2 NALCN FHL3	5.93e-06	188	106	6	d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG6 ACSM3 PTPRD TENM3 ENPEP SDK1	6.11e-06	189	106	6	28b502611829e4a24caff2562545c7db97686099
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 RYR2 PTPRD PTPRS PAPPA SDK1	6.11e-06	189	106	6	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 RYR2 PTPRD TENM3 PAPPA SDK1	6.30e-06	190	106	6	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 RYR2 PTPRD TENM3 PAPPA SDK1	6.49e-06	191	106	6	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR2 ADGRG6 NALCN PTPRS PAPPA SDK1	6.49e-06	191	106	6	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	ISYNA1 GJC1 RYR2 RGS6 CSMD1 ENPEP	6.49e-06	191	106	6	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS23 PKHD1L1 CRIP2 NRP2 NALCN CTSL	6.69e-06	192	106	6	5388f3115ab285f3f3001af1d71543ed64b9e044
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 RYR2 PTPRD TENM3 PAPPA SDK1	6.69e-06	192	106	6	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 RYR2 PTPRD TENM3 PAPPA SDK1	6.69e-06	192	106	6	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS23 PKHD1L1 CRIP2 NRP2 NALCN CTSL	6.89e-06	193	106	6	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC19A2 ABCA10 USP2 PTPRS PAPPA SDK1	6.89e-06	193	106	6	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 RYR2 PTPRD TENM3 PTPRS SDK1	7.09e-06	194	106	6	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRIP2 NRP2 TENM3 HEBP1 FHL3 CDH18	7.52e-06	196	106	6	308fa54385ca34e9e590967d4553b84aad96c92f
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 GJC1 CRIP2 RYR2 USP2 RGS6	7.52e-06	196	106	6	ce6f7ddb8104471dc90347f427486379914d63b4
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 GJC1 CRIP2 RYR2 USP2 RGS6	7.52e-06	196	106	6	6d7179decea512dd49bb2d5f6a4f5989349d52a9
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ISYNA1 GJC1 CRIP2 USP2 RGS6 WDR1	7.52e-06	196	106	6	1d94cecd378a829dd8014fc086d7fca48c953a91
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ISYNA1 GJC1 CRIP2 USP2 RGS6 WDR1	7.52e-06	196	106	6	aacec48285bcb7ccf1b538187071885e3602cc49
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ISYNA1 A1CF GJC1 USP2 CTSL SDK1	7.74e-06	197	106	6	3332b9b5bf78f0203ebbd94257a36e9054d896c3
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	ABCA10 RYR2 TENM3 PTPRS PAPPA SDK1	7.74e-06	197	106	6	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 GJC1 CRIP2 RYR2 RGS6 HPR	7.74e-06	197	106	6	68c23c23b6924892f4c238cf2f5abc7927e04fbc
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Pericytes\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ISYNA1 GJC1 PRSS23 CRIP2 ENPEP CNR1	7.97e-06	198	106	6	5e274c5597d8720290d452465f0bd40637cb3f27
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EML6 TTC3 RYR2 STXBP1 CSMD1 CDH18	7.97e-06	198	106	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EML6 RYR2 STXBP1 PCDH11X CSMD1 CDH18	7.97e-06	198	106	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CHL1 PRSS23 ST14 PTPRF PIGR ALDH3A1	7.97e-06	198	106	6	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ISYNA1 RYR2 RGS6 PAPPA ENPEP CNR1	7.97e-06	198	106	6	dc6d9032c5029527e184ac13b887c0c1f22ef1c0
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CHL1 ISYNA1 PRSS23 ALDH3A1 CSMD1 SDK1	8.20e-06	199	106	6	94a7867e800df352731796de8c24cba133c29622
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	ABCA10 RYR2 TENM3 PTPRS ENPEP SDK1	8.20e-06	199	106	6	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_intermediate\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SMARCA5 ISYNA1 ST14 ACSM3 PTPRF C5	8.20e-06	199	106	6	debdd7dba774d9ccff7effc3f4c132393d203dfa
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PDHB EPB41L5 CRIP2 LSR PTPRF HEBP1	8.20e-06	199	106	6	8c9ec5f05b79cf5ae1bf7aade603c171fb0226a9
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NRP2 PTPRF PIGR HECTD2 PCDH11X C5	8.44e-06	200	106	6	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	control-Epithelial\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CHL1 PRSS23 ST14 PTPRF PIGR ALDH3A1	8.44e-06	200	106	6	f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCell	NS-moderate-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CHL1 PRSS23 TTC3 PTPRF PIGR ALDH3A1	8.44e-06	200	106	6	64462a18afca3c1a8548a857924b8166058bf958
ToppCell	NS-control-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CHL1 PRSS23 ST14 PTPRF PIGR ALDH3A1	8.44e-06	200	106	6	d014959891893b6d3854a471fba1dc50c6625a0a
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA10 RYR2 TENM3 PTPRS PAPPA SDK1	8.44e-06	200	106	6	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA10 RYR2 TENM3 PTPRS ENPEP SDK1	8.44e-06	200	106	6	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Tracheal-10x5prime-Epithelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CHL1 ST14 LSR PTPRF PIGR ALDH3A1	8.44e-06	200	106	6	efd461c687155c84ef590352207e6fe4ba392a90
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ISYNA1 CAPN1 PRSS23 ST14 CRIP2 LSR	8.44e-06	200	106	6	694ebc8cc14f80b6f2f4acec4ce7452d8b816af8
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ISYNA1 CAPN1 PRSS23 CSTA ALDH3A1 EIF2A	8.44e-06	200	106	6	ea1325ca6039c6d2318b1ceb9d396399bb21b670
ToppCell	Bronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RIBC1 GJC1 RGS6 BPIFB4 ENPEP	1.73e-05	134	106	5	bffd6ce8998368d4f486b64c220eab3a44ba147b
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRSS23 LSR PIGR ALDH3A1 CDK3	4.17e-05	161	106	5	9cfbbcd38ec2e75376bbc26001964b6991ad0e21
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 SLC19A2 PKHD1L1 RYR2 CSMD1	4.69e-05	165	106	5	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 SLC19A2 PKHD1L1 RYR2 CSMD1	4.69e-05	165	106	5	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	COVID-19-Heart-Adipocyte\|Heart / Disease (COVID-19 only), tissue and cell type	SLC19A2 PTPRF TENM3 CNR1 KLB	5.26e-05	169	106	5	bd39f85b48207955f80ca120a11e15a0124117b9
ToppCell	severe-Myeloid-Eosinophils\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FLNB STON1 CDK15 ACSM3 MAP4K5	5.41e-05	170	106	5	863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPB41L5 PRSS23 BNC1 PIGR SDK1	5.56e-05	171	106	5	eddc5e05003382603ee49f74b9e2242a43021096
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR2 RGS6 PAPPA CSMD1 SDK1	5.56e-05	171	106	5	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	PRSS23 CRIP2 ADGRG6 LSR SHOC1	5.71e-05	172	106	5	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDK15 PRSS23 BNC1 FHL3 CNR1	5.87e-05	173	106	5	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Airway_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CHL1 PRSS23 RGS6 TENM3 CDH18	5.87e-05	173	106	5	b23b408acc29a667cce104429afef1a6cf2720a5
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PKHD1L1 BNC1 PTPRD TENM3 PAPPA	5.87e-05	173	106	5	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ISYNA1 GJC1 RYR2 RGS6 CNR1	5.87e-05	173	106	5	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RYR2 RGS6 PAPPA CSMD1 ENPEP	6.04e-05	174	106	5	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	3'-Adult-LymphNode-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 GJC1 USP2 RGS6 ENPEP	6.37e-05	176	106	5	56e19240f4a7b617a986e3c0854b757394e78251
ToppCell	3'-Adult-LymphNode-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 GJC1 USP2 RGS6 ENPEP	6.37e-05	176	106	5	c88b46fe29ae7606c8880a6ff0ebb85c0dfda8bd
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PKHD1L1 CRIP2 NRP2 HEBP1 FHL3	6.37e-05	176	106	5	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 A1CF PTPRD SMARCA1 KLB	6.55e-05	177	106	5	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 A1CF PTPRD SMARCA1 KLB	6.55e-05	177	106	5	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 GJC1 CRIP2 RYR2 ENPEP	6.72e-05	178	106	5	e5e4742e35c3d90f82b830d77bdbdc45828c7deb
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDK15 PKHD1L1 BNC1 TENM3 PAPPA	6.72e-05	178	106	5	a107dd98a07086ed0429116095ecda60c9dbef1e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALS1 PTPRD TENM3 NALCN ENPEP	6.90e-05	179	106	5	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CAMKK1 PRSS23 CFLAR TENM3 CNR1	6.90e-05	179	106	5	747a32460b257fffca30527b56a74720eb9c12e4
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RYR2 ADGRG6 DNASE2B SMARCA1 CNR1	6.90e-05	179	106	5	f5bb4d3a27d56698473219970e764084096cc582
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A1CF ADGRG6 PTPRD ENPEP TUBAL3	6.90e-05	179	106	5	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB PRSS23 USP2 CEP152 CTSL	6.90e-05	179	106	5	ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 PKHD1L1 CRIP2 PTPRS SMARCA1	6.90e-05	179	106	5	ec1d7017da325647b629de703135a404bbdc627d
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Macrophage\|lymph-node_spleen / Manually curated celltypes from each tissue	NRAP CHIT1 NRP2 DNASE2B CTSL	6.90e-05	179	106	5	b4430f633711cecf793e8e76e766a66ff1eff473
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RYR2 ADGRG6 DNASE2B SMARCA1 CNR1	6.90e-05	179	106	5	fa03ec3cc0132f977b4cb28e7b23789732375183
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CHL1 EML6 TENM3 PAPPA CSMD1	7.09e-05	180	106	5	1e819c5c87704ec6535dfeaae56561895e239d07
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP4K3 RYR2 ADGRG6 DNASE2B SMARCA1	7.09e-05	180	106	5	f6a05b3751b01e74b2de8440801b0eb2e723c199
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP4K3 RYR2 ADGRG6 DNASE2B SMARCA1	7.09e-05	180	106	5	dfc75ae4395ff46fbec2c54915d98ead5a1ba1a1
ToppCell	severe-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FLNB STON1 CDK15 ACSM3 MAP4K5	7.09e-05	180	106	5	ac03812b1409435c55d323a7516deeac82bd3509
ToppCell	facs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISYNA1 CDK15 GJC1 PRSS23 ENPEP	7.27e-05	181	106	5	429df38438d5a7ff490c9ede34b69e2970c7ded2
ToppCell	facs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISYNA1 CDK15 GJC1 PRSS23 ENPEP	7.27e-05	181	106	5	395cf5aa2d89b05328ab516b8c89401020b6d830
ToppCell	facs-Marrow-T-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB DNASE2B PTPRF PTPRS CTSL	7.27e-05	181	106	5	7286700396676fdc41d9723979b8b408177aceb9
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ST6GALNAC6 LSR PTPRD PTPRF KLB	7.47e-05	182	106	5	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 PTPRF PAPPA CSMD1 FHL3	7.47e-05	182	106	5	6fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ST6GALNAC6 LSR PTPRD PTPRF KLB	7.47e-05	182	106	5	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHIT1 PKHD1L1 BNC1 TENM3 PAPPA	7.47e-05	182	106	5	9966f42c338cbd471efa8ffc765a6ce93693aa75
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ST6GALNAC6 LSR PTPRD PTPRF KLB	7.47e-05	182	106	5	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR2 ADGRG6 NALCN PTPRS PAPPA	7.66e-05	183	106	5	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPB41L5 PALS1 PTPRD TENM3 ENPEP	7.66e-05	183	106	5	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPB41L5 PALS1 PTPRD TENM3 ENPEP	7.66e-05	183	106	5	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CHL1 SLC19A2 PRSS23 TENM3 MAP4K5	7.66e-05	183	106	5	1464b5c4425e8776c4aeb4d2b560481d4bf13931
Drug	Roxithromycin [80214-83-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A	ERCC4 GLS2 EML2 CFLAR MTMR6 VPS13D CSTA ATP6V0A2	3.05e-06	190	106	8	3331_DN
Drug	3-methyladenine	ERCC4 CAPN1 PIKFYVE PABPN1 HPR CTSL CNR1	3.14e-06	134	106	7	CID000001673
Disease	azoospermia (implicated_via_orthology)	ISYNA1 PTPRD PTPRF PTPRS	2.40e-06	27	104	4	DOID:14227 (implicated_via_orthology)
Disease	bitter alcoholic beverage consumption measurement	ERCC4 PTPRD MAP4K5 CSMD1 KLB	1.11e-04	133	104	5	EFO_0010092
Disease	Addison's disease (is_implicated_in)	PTPN22 CLEC16A	1.22e-04	5	104	2	DOID:13774 (is_implicated_in)
Disease	uridine measurement	ERCC4 NALCN CSMD1	1.96e-04	32	104	3	EFO_0010546
Disease	Neurodevelopmental delay	CARS1 MYSM1	2.55e-04	7	104	2	C4022738
Disease	centronuclear myopathy (implicated_via_orthology)	MTMR6 MTMR7	2.55e-04	7	104	2	DOID:14717 (implicated_via_orthology)
Disease	group XIIB secretory phospholipase A2-like protein measurement	PON3 MAP4K5	2.55e-04	7	104	2	EFO_0801657
Disease	pit and fissure surface dental caries	BCOR ADGRG6 PTPRD	2.56e-04	35	104	3	EFO_0006338
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	FLNB GLS2 PTPN22	3.28e-04	38	104	3	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	ulcerative colitis (is_marker_for)	PON3 ACSM3 ALPI	3.82e-04	40	104	3	DOID:8577 (is_marker_for)
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR6 MTMR7	4.36e-04	9	104	2	DOID:0111225 (implicated_via_orthology)
Disease	response to carboplatin, response to antineoplastic agent	FLNB CSMD1	5.44e-04	10	104	2	GO_0097327, GO_0097328
Disease	protein intake measurement	MAP4K5 KLB	5.44e-04	10	104	2	EFO_0010810
Disease	disease progression measurement, Crohn's disease	PTPRD CSMD1 SDK1	6.16e-04	47	104	3	EFO_0000384, EFO_0008336
Disease	alcohol use disorder (implicated_via_orthology)	MAP4K3 RYR2 STXBP1 MAP4K5 CTSL	6.49e-04	195	104	5	DOID:1574 (implicated_via_orthology)
Disease	fibroblast growth factor 21 measurement	RGS6 MAP4K5	6.63e-04	11	104	2	EFO_0010783
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	ERCC4 RGS6 PTPRF RPTOR CSMD1	7.27e-04	200	104	5	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	alcohol consumption measurement, alcohol drinking	MAP4K5 KLB	7.94e-04	12	104	2	EFO_0004329, EFO_0007878
Disease	Colorectal Carcinoma	CHL1 POLD1 EML2 ABCA10 PTPRD GUCY2C PTPRS PCDH11X FHL3	8.55e-04	702	104	9	C0009402
Disease	serum selenium measurement	MTMR7 CEP152 CSMD1	8.77e-04	53	104	3	EFO_0005266
Disease	triacylglycerol 46:2 measurement	MAP4K5 CSMD1	1.09e-03	14	104	2	EFO_0010402
Disease	triacylglycerol 52:1 measurement	MAP4K5 CSMD1	1.09e-03	14	104	2	EFO_0010413
Disease	eating disorder, bipolar disorder	RYR2 NALCN	1.09e-03	14	104	2	EFO_0005203, MONDO_0004985
Disease	adverse effect, response to xenobiotic stimulus	GLS2 STON1 ST14	1.20e-03	59	104	3	EFO_0009658, GO_0009410
Disease	insulin resistance	PTPRD MAP4K5 CSMD1	1.20e-03	59	104	3	EFO_0002614
Disease	hepcidin:transferrin saturation ratio	PDHB EML6	1.25e-03	15	104	2	EFO_0007902
Disease	YKL40 measurement	CHIT1 MAP4K5	1.25e-03	15	104	2	EFO_0004869
Disease	response to triptolide, cytotoxicity measurement	CFLAR CSMD1	1.43e-03	16	104	2	EFO_0006952, EFO_0007662
Disease	central nervous system disease (implicated_via_orthology)	SMARCA5 SMARCA1	1.43e-03	16	104	2	DOID:331 (implicated_via_orthology)
Disease	partial epilepsy	SMARCA5 PTPRD	1.62e-03	17	104	2	EFO_0004263
Disease	theta wave measurement	CHIT1 CLEC16A	1.62e-03	17	104	2	EFO_0006873
Disease	triacylglycerol 48:1 measurement	MAP4K5 CSMD1	1.62e-03	17	104	2	EFO_0010404
Disease	Liver Cirrhosis, Experimental	ISYNA1 GLS2 SLC19A2 RMDN2 ST14 MTMR7 PTPRD ENPEP CNR1	1.68e-03	774	104	9	C0023893
Disease	Child Behaviour Checklist assessment	RIPK1 TENM3	1.81e-03	18	104	2	EFO_0005661
Disease	glucuronate measurement	EPB41L5 MTMR7	1.81e-03	18	104	2	EFO_0010486
Disease	sarcopenia	RGS6 PTPRD	2.24e-03	20	104	2	EFO_1000653
Disease	exercise test	RYR2 PTPRD	2.24e-03	20	104	2	EFO_0004328
Disease	triacylglycerol 46:1 measurement	MAP4K5 CSMD1	2.24e-03	20	104	2	EFO_0010401
Disease	prothrombin time measurement	SLC19A2 MAP4K5	2.47e-03	21	104	2	EFO_0008390
Disease	Attention Deficit Disorder	PTPRD CNR1	2.71e-03	22	104	2	C0041671
Disease	Minimal Brain Dysfunction	PTPRD CNR1	2.71e-03	22	104	2	C1321905
Disease	triacylglycerol 48:2 measurement	MAP4K5 CSMD1	2.71e-03	22	104	2	EFO_0010405
Disease	triacylglycerol 48:3 measurement	MAP4K5 CSMD1	2.71e-03	22	104	2	EFO_0010406
Disease	amino acid measurement	GLS2 CHIT1 RYR2 NRP2 GUCY2C MAP4K5 C5 CSMD1	2.78e-03	678	104	8	EFO_0005134
Disease	Immunologic Deficiency Syndromes	MYSM1 C5	2.97e-03	23	104	2	C0021051
Disease	Colorectal Neoplasms	POLD1 ABCA10 PTPRD GUCY2C FHL3	3.04e-03	277	104	5	C0009404
Disease	Hodgkins lymphoma	PTPN22 ACSM3 CLEC16A	3.08e-03	82	104	3	EFO_0000183
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR6 MTMR7	3.23e-03	24	104	2	DOID:10595 (implicated_via_orthology)
Disease	airway responsiveness measurement	RPTOR CSMD1	3.23e-03	24	104	2	EFO_0006897
Disease	Attention deficit hyperactivity disorder	PTPRD CNR1	3.23e-03	24	104	2	C1263846
Disease	nicotine dependence symptom count	STON1 ADGRG6 SLC5A4 RPTOR CSMD1	3.43e-03	285	104	5	EFO_0009262

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDVNNYKGRYSEGDT	TTF1	611	Q15361
VNGYNEIQSLYAGEK	CEP152	86	O94986
ISGDGFSYRDTVVYQ	CSMD1	2691	Q96PZ7
RTGYSLVQENGQRKY	A1CF	26	Q9NQ94
YNGAIIVSGDQKDYR	ABCA10	866	Q8WWZ4
ETNDNTAQLGGKYRY	BPIFB4	91	P59827
YREKSNYVGATFQGK	ADAM2	271	Q99965
ASRNNNEVYGKESYG	ADGRG6	991	Q86SQ4
QKVAYGGTGDAATRY	ALDH3A1	301	P30838
SYNGLYGVAVFSQKD	FBXO10	666	Q9UK96
QDYIRGYVLQDASGK	BNC1	136	Q01954
YHYQSEGTERQKGQS	FLG	3956	P20930
GHAYSVTGAKQVNYR	CAPN1	271	P07384
GEYYVENADGKVTVR	BCOR	1381	Q6W2J9
YKQSVQGAGTSYRNV	CFLAR	171	O15519
KREGGIDYQAGDTYV	CDK13	1316	Q14004
SYEITSQNVKDGGRY	RGS6	406	P49758
NISQKGDVYSYGIIA	GUCY2C	656	P25092
DSSYINANFIKGVYG	PTPN22	81	Q9Y2R2
SGRKEANYYGSLTQA	ISYNA1	91	Q9NPH2
AGQTYVDAGYEVDKI	CHIT1	186	Q13231
LGEEVAQYDGAYKVS	PDHB	56	P11177
TYGDVYKARNVNTGE	MAP4K3	26	Q8IVH8
QTKDGENYATVVGYS	CHL1	426	O00533
VRYTEDYEQQRGKGS	NRAP	226	Q86VF7
IKVGSESVVYTGDYN	INTS11	166	Q5TA45
AGKGYENEDNYSNIR	MTMR6	251	Q9Y217
RAAGKGYENEDNYSN	MTMR7	251	Q9Y216
SKNYAEVGRVGYVSG	HPR	211	P00739
KGAYGVVRLAYNESE	CAMKK1	136	Q8N5S9
ALQRSTQYDGYAKTD	HECTD2	671	Q5U5R9
SIQNNKDGTYAVTYV	FLNB	1181	O75369
GAISRETQNGYYVKS	NRP2	346	O60462
FQSEKETGDRNYAIG	GLS2	311	Q9UI32
VGFYRTTYTENGQVK	ENPEP	201	Q07075
QESYTFYVKAEDGGR	PCDH11X	636	Q9BZA7
DGTYYGDQKQETISV	PAPPA	1106	Q13219
IDGYRQQKAYIATQG	PTPRS	1741	Q13332
AQDSKAYTSILYGNG	ALPI	401	P09923
RVYESIGQYGGETVK	PALS1	241	Q8N3R9
VENLGVSYVKGTEQY	PRIM2	56	P49643
ARSIYVGNVDYGATA	PABPN1	171	Q86U42
GEGTYGVVYKAKNRE	CDK3	11	Q00526
AYYQVGQTGKEGTEN	PIKFYVE	1771	Q9Y2I7
KEYRGQTPAQAETNY	EPB41L5	206	Q9HCM4
NESLYGRKYIQTDSG	FHL3	11	Q13643
RQNKESGETGLEYLY	DNASE2B	51	Q8WZ79
EGSYATVYKGISRIN	CDK15	111	Q96Q40
TAVGGESIYYDEQSK	GJC1	36	P36383
GEQIQLKGTVYNYRT	C5	836	P01031
LYVGSNDIQYEDIKG	CNR1	21	P21554
QVVAGTNYYIKVRAG	CSTA	46	P01040
QTYAYEGQRSEAGSI	CDH18	736	Q13634
DGIVTVANAKGLQYY	KLB	161	Q86Z14
DNLVYVYTVDQGGRK	EML2	481	O95834
DGKYIQVSTGAYKRQ	EML6	1826	Q6ZMW3
TDVDKTGASYYGEQT	EIF2A	241	Q9BY44
KGVNTGAVGSYIYDR	CRIP2	186	P52943
LAQDTGTGTAYIEYK	DIP2A	501	Q14689
TGGSVYKYASFQVEN	SEC24C	716	P53992
AGAYYVQAVNEKNGE	SDK1	256	Q7Z5N4
SRYAAIYNGGVEAVS	SLC19A2	326	O60779
YYSGKDVIDEQGQRN	RYR2	3891	Q92736
VENGYSTSAKVVYGD	POLD1	741	P28340
VATKQGNAVTLGDYY	LSR	176	Q86X29
VGSGTYGDVYKARNV	MAP4K5	26	Q9Y4K4
IDGYRKQNAYIATQG	PTPRF	1411	P10586
IDGYRKQNAYIATQG	PTPRD	1416	P23468
DYSNQQSGYGKVSRR	HNRNPD	331	Q14103
YGQSTYSRQIKQVED	PSMC2	36	P35998
FVQKIVDNGYGYVSN	CARS1	251	P49589
RIQYGTSKGKNYTEE	SMARCA1	951	P28370
YANGSRTETQVGIYI	PRSS23	91	O95084
TGYSADVGNKTTYRV	ST6GALNAC6	141	Q969X2
YQYLGLGETVQEDKT	SHOC1	1146	Q5VXU9
VGGYESFTEKYVNAT	SLC5A4	226	Q9NY91
YVSEFEGLQNKINYG	RMDN2	271	Q96LZ7
SGKEDAANNYARGRY	TUBAL3	101	A6NHL2
TASADGQIYIYDGKT	WDR1	206	O75083
YENFQNTEGKGTAYS	RIPK1	426	Q13546
NDVYKYETSGIGEAR	STXBP1	261	P61764
NSSGELINNIKYYDG	RPTOR	1281	Q8N122
VGYGFESTESDNNKY	CTSL	281	P07711
NKTGLDIYEGYGQTE	ACSM3	366	Q53FZ2
LYVYSLENQDKGGER	CLEC16A	291	Q2KHT3
DVVGAATAGQTYYRS	CNGB1	881	Q14028
IDLKGVEGYGNDQTY	SUPT6H	671	Q7KZ85
VYLIDSGAQYKDGTT	XPNPEP1	411	Q9NQW7
SKEAAYGTSQVQYDV	RIBC1	61	Q8N443
QVTVGSAKYESAYQA	STON1	616	Q9Y6Q2
YVEINGEKYCGERSQ	ST14	401	Q9Y5Y6
NYKEAQEYGSFGTAE	TPP2	226	P29144
DGVGVQYKDYIQSER	TTC3	46	P53804
AYNQKVYGLSEAVVS	TENM3	1066	Q9P273
SANGITVSADQKYVY	PON3	221	Q15166
KYNVGAAESSYREVV	PKHD1L1	3086	Q86WI1
EGYVSSKYAGRANLT	PIGR	71	P01833
EITSNSRYEVYTQGG	ERCC4	91	Q92889
YTTVDANGYLKNGSA	ITFG1	471	Q8TB96
RISYGTNKGKNYTEE	SMARCA5	936	O60264
VDYLENYGRKGSASQ	USP2	196	O75604
SKTSGLYTGQEYVQR	ATP6V0A2	636	Q9Y487
KNQYVVSIGNSVGYE	VPS13D	1231	Q5THJ4
GGYAKEADYVAQATR	HEBP1	136	Q9NRV9
VDVIVAASNYYKGEN	NALCN	396	Q8IZF0
DTQAKYQSYFSRGGA	MYSM1	671	Q5VVJ2