Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	CDK8 CUL3 RAG2 TRIML2 MED23 RNF139 PIAS2 FBXO15 TRIM23	9.97e-05	398	93	9	GO:0061659
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH2 DYNC1H1	4.18e-05	14	93	3	IPR011704
Domain	AAA_5	MDN1 DNAH2 DYNC1H1	4.18e-05	14	93	3	PF07728
Domain	ARM-type_fold	DOCK3 GBF1 HEATR6 NF1 UNC45B CIP2A MROH5 TNPO3 IPO11	4.85e-05	339	93	9	IPR016024
Domain	FERM_domain	JAK3 PTK2B FRMD6 FRMPD1	1.03e-04	49	93	4	IPR000299
Domain	FERM_1	JAK3 PTK2B FRMD6 FRMPD1	1.11e-04	50	93	4	PS00660
Domain	FERM_2	JAK3 PTK2B FRMD6 FRMPD1	1.11e-04	50	93	4	PS00661
Domain	FERM_3	JAK3 PTK2B FRMD6 FRMPD1	1.11e-04	50	93	4	PS50057
Domain	Band_41_domain	JAK3 PTK2B FRMD6 FRMPD1	1.11e-04	50	93	4	IPR019749
Domain	B41	JAK3 PTK2B FRMD6 FRMPD1	1.11e-04	50	93	4	SM00295
Domain	-	HEATR6 NF1 UNC45B CIP2A MROH5 TNPO3 IPO11	1.22e-04	222	93	7	1.25.10.10
Domain	NACHT	NLRC5 NLRP8 NLRP5	1.97e-04	23	93	3	PS50837
Domain	NACHT_NTPase	NLRC5 NLRP8 NLRP5	1.97e-04	23	93	3	IPR007111
Domain	DOCK_N	DOCK3 DOCK4	2.43e-04	5	93	2	PF16172
Domain	DOCK_N	DOCK3 DOCK4	2.43e-04	5	93	2	IPR032376
Domain	ARM-like	HEATR6 NF1 UNC45B CIP2A MROH5 TNPO3 IPO11	4.01e-04	270	93	7	IPR011989
Domain	GAF	PDE2A PDE6C	5.07e-04	7	93	2	PF01590
Domain	DHC_N1	DNAH2 DYNC1H1	6.74e-04	8	93	2	PF08385
Domain	GAF	PDE2A PDE6C	6.74e-04	8	93	2	IPR003018
Domain	GAF	PDE2A PDE6C	6.74e-04	8	93	2	SM00065
Domain	Dynein_heavy_dom-1	DNAH2 DYNC1H1	6.74e-04	8	93	2	IPR013594
Domain	GAF_dom-like	PDE2A PDE6C	8.63e-04	9	93	2	IPR029016
Domain	-	PDE2A PDE6C	8.63e-04	9	93	2	3.30.450.40
Domain	Elongated_TPR_rpt_dom	UNC45B FKBP4	1.31e-03	11	93	2	IPR023114
Domain	DOCK_C	DOCK3 DOCK4	1.31e-03	11	93	2	IPR010703
Domain	DHR-1_domain	DOCK3 DOCK4	1.31e-03	11	93	2	IPR027007
Domain	DHR_2	DOCK3 DOCK4	1.31e-03	11	93	2	PS51651
Domain	DHR_1	DOCK3 DOCK4	1.31e-03	11	93	2	PS51650
Domain	DOCK-C2	DOCK3 DOCK4	1.31e-03	11	93	2	PF14429
Domain	DHR-2	DOCK3 DOCK4	1.31e-03	11	93	2	IPR027357
Domain	DHR-2	DOCK3 DOCK4	1.31e-03	11	93	2	PF06920
Domain	DOCK	DOCK3 DOCK4	1.31e-03	11	93	2	IPR026791
Domain	FERM_M	PTK2B FRMD6 FRMPD1	1.55e-03	46	93	3	PF00373
Domain	-	PTK2B FRMD6 FRMPD1	1.87e-03	49	93	3	1.20.80.10
Domain	FERM_central	PTK2B FRMD6 FRMPD1	1.87e-03	49	93	3	IPR019748
Domain	FERM/acyl-CoA-bd_prot_3-hlx	PTK2B FRMD6 FRMPD1	1.98e-03	50	93	3	IPR014352
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DYNC1H1	2.15e-03	14	93	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DYNC1H1	2.15e-03	14	93	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DYNC1H1	2.15e-03	14	93	2	IPR013602
Domain	DHC_N2	DNAH2 DYNC1H1	2.15e-03	14	93	2	PF08393
Domain	MT	DNAH2 DYNC1H1	2.15e-03	14	93	2	PF12777
Domain	AAA_8	DNAH2 DYNC1H1	2.15e-03	14	93	2	PF12780
Domain	DHC_fam	DNAH2 DYNC1H1	2.47e-03	15	93	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DYNC1H1	2.47e-03	15	93	2	IPR004273
Domain	Dynein_heavy	DNAH2 DYNC1H1	2.47e-03	15	93	2	PF03028
Domain	LRR_6	NLRC5 NLRP8 NLRP5	2.60e-03	55	93	3	PF13516
Domain	PDEase	PDE2A PDE6C	3.97e-03	19	93	2	IPR023088
Domain	PDEase_I	PDE2A PDE6C	4.84e-03	21	93	2	PF00233
Domain	PDEASE_I	PDE2A PDE6C	4.84e-03	21	93	2	PS00126
Domain	PDEase_CS	PDE2A PDE6C	4.84e-03	21	93	2	IPR023174
Pubmed	A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.	CDK8 MED15 POLR2A CDK19 MED23	1.82e-07	47	94	5	15175163
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK8 POLR2A CDK19	1.90e-07	5	94	3	36545778
Pubmed	Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.	CDK8 MED15 CDK19	1.06e-06	8	94	3	23749998
Pubmed	A protein interaction landscape of breast cancer.	DOCK4 GBF1 HEATR6 MDN1 FRMD6 CIP2A POLR2A E2F1 TNPO3 FKBP4 ZC3HAV1	1.19e-06	634	94	11	34591612
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	USP5 GBF1 MDN1 CIP2A POLR2A DNM1L TNPO3 FKBP4 DYNC1H1 IPO11 ZC3HAV1	1.27e-06	638	94	11	33239621
Pubmed	High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12.	POLR2A DIO3 DYNC1H1	1.59e-06	9	94	3	16309881
Pubmed	Human mediator subunit MED26 functions as a docking site for transcription elongation factors.	CDK8 MED15 POLR2A CDK19 MED23	1.68e-06	73	94	5	21729782
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	MED15 MDN1 POLR2A NLRC5 E2F1 MED23 TERF2 TNPO3 DYNC1H1 IPO11	1.88e-06	533	94	10	30554943
Pubmed	MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.	CDK8 MED15 POLR2A MED23	2.18e-06	34	94	4	15989967
Pubmed	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	CDK8 MED15 MED23	2.26e-06	10	94	3	23746844
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CUL3 DOCK4 GBF1 MDN1 CIP2A ADNP2 DNM1L TERF2 PIAS2 LDLR IPO11	2.65e-06	689	94	11	36543142
Pubmed	A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.	CDK8 MED15 MED23	5.36e-06	13	94	3	14657022
Pubmed	CDK8 is a positive regulator of transcriptional elongation within the serum response network.	CDK8 MED15 MED23	5.36e-06	13	94	3	20098423
Pubmed	Structure, function, and activator-induced conformations of the CRSP coactivator.	CDK8 MED15 MED23	6.81e-06	14	94	3	11834832
Pubmed	Leukocyte CD11b expression is not essential for the development of atherosclerosis in mice.	ITGAM LDLR	7.23e-06	2	94	2	10884286
Pubmed	ABCC6 deficiency promotes dyslipidemia and atherosclerosis.	LDLR ABCC6	7.23e-06	2	94	2	33594095
Pubmed	Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.	CDK8 CDK19	7.23e-06	2	94	2	35181333
Pubmed	Regulatory functions of the Mediator kinases CDK8 and CDK19.	CDK8 CDK19	7.23e-06	2	94	2	30585107
Pubmed	Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.	NF1 DYNC1H1	7.23e-06	2	94	2	23583712
Pubmed	Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice.	JAK3 RAG2	7.23e-06	2	94	2	21331358
Pubmed	HIV Transcription Is Independent of Mediator Kinases.	CDK8 CDK19	7.23e-06	2	94	2	31044597
Pubmed	Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.	JAK3 PTK2B	7.23e-06	2	94	2	9512511
Pubmed	Functional Intraregional and Interregional Heterogeneity between Myenteric Glial Cells of the Colon and Duodenum in Mice.	POLR2A E2F1	7.23e-06	2	94	2	36319118
Pubmed	Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.	CDK8 CDK19	7.23e-06	2	94	2	32560467
Pubmed	CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mice.	ITGAM LDLR	7.23e-06	2	94	2	27234908
Pubmed	E2F Transcription Factor 1 Activates FKBP Prolyl Isomerase 4 to Promote Angiogenesis in Cervical Squamous Cell Carcinoma Via the PI3K/AKT Signaling Pathway.	E2F1 FKBP4	7.23e-06	2	94	2	35849266
Pubmed	[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].	CDK8 CDK19	7.23e-06	2	94	2	20408451
Pubmed	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	CDK8 CDK19	7.23e-06	2	94	2	26416749
Pubmed	CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	CDK8 CDK19	7.23e-06	2	94	2	28855340
Pubmed	A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.	RAG2 E2F1	7.23e-06	2	94	2	10616908
Pubmed	Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.	CDK8 CDK19	7.23e-06	2	94	2	27678455
Pubmed	Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity.	NEK2 CIP2A	7.23e-06	2	94	2	24214971
Pubmed	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	CDK8 CDK19	7.23e-06	2	94	2	36006697
Pubmed	BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus.	POLR2A E2F1	7.23e-06	2	94	2	37198101
Pubmed	CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.	CDK8 CDK19	7.23e-06	2	94	2	37378433
Pubmed	CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation.	CDK8 E2F1	7.23e-06	2	94	2	22945643
Pubmed	Circuit-specific enteric glia regulate intestinal motor neurocircuits.	POLR2A E2F1	7.23e-06	2	94	2	34593632
Pubmed	Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy.	RAG2 ACVR1C	7.23e-06	2	94	2	38235319
Pubmed	Identification of target genes for the CDK subunits of the Mediator complex.	CDK8 CDK19	7.23e-06	2	94	2	22117896
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	CDK8 MED15 MED23	8.50e-06	15	94	3	18418385
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	CUL3 PTK2B NF1 PPFIA2 DNM1L DYNC1H1 CYFIP2	1.17e-05	281	94	7	28706196
Pubmed	Defining the membrane proteome of NK cells.	MED15 CUL3 GBF1 NF1 MDN1 LNPEP DNM1L ZDHHC3 LDLR PIGO DYNC1H1 CYFIP2 SLC4A2	1.57e-05	1168	94	13	19946888
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	CDK8 MED15 MED23	1.80e-05	19	94	3	16799563
Pubmed	Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.	DNM1L LDLR	2.16e-05	3	94	2	28607103
Pubmed	Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.	CDK8 CDK19	2.16e-05	3	94	2	26002960
Pubmed	The proline-rich tyrosine kinase Pyk2 modulates integrin-mediated neutrophil adhesion and reactive oxygen species generation.	PTK2B ITGAM	2.16e-05	3	94	2	32693110
Pubmed	Suppressor of Cytokine Signaling 1 is Involved in Gene Regulation Which Controls the Survival of Ly6Clow Monocytes in Mice.	RAG2 LDLR	2.16e-05	3	94	2	30816678
Pubmed	DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.	SPO11 PIWIL4	2.16e-05	3	94	2	26109049
Pubmed	E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.	CDK8 E2F1	2.16e-05	3	94	2	18794899
Pubmed	LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction.	POLR2A E2F1	2.16e-05	3	94	2	35166239
Pubmed	Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.	CDK8 CDK19	2.16e-05	3	94	2	28151579
Pubmed	Role of suppressor of cytokine signaling-1 in murine atherosclerosis.	RAG2 LDLR	2.16e-05	3	94	2	23300554
Pubmed	Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.	CDK8 POLR2A	2.16e-05	3	94	2	8700522
Pubmed	Pharmacological Inhibition of CDK8 in Triple-Negative Breast Cancer Cell Line MDA-MB-468 Increases E2F1 Protein, Induces Phosphorylation of STAT3 and Apoptosis.	CDK8 E2F1	2.16e-05	3	94	2	33291686
Pubmed	KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males.	E2F1 FKBP4	2.16e-05	3	94	2	34688635
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR5M1 OR10V1 OR1L6 OR1F2P OR1K1 OR1L4	2.99e-05	219	94	6	12213199
Pubmed	Streamlined analysis schema for high-throughput identification of endogenous protein complexes.	MED15 POLR2A CDK19 MED23	4.23e-05	71	94	4	20133760
Pubmed	Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading.	PTK2B BCAR3	4.32e-05	4	94	2	19086031
Pubmed	Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations.	POLR2A TERF2	4.32e-05	4	94	2	19887628
Pubmed	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	CDK8 CDK19	4.32e-05	4	94	2	29440396
Pubmed	Ras induces mediator complex exchange on C/EBP beta.	CDK8 MED23	4.32e-05	4	94	2	14759369
Pubmed	Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein.	CDK8 MED23	4.32e-05	4	94	2	10353252
Pubmed	Identification of a secondary promoter of CASP8 and its related transcription factor PURα.	POLR2A E2F1	4.32e-05	4	94	2	24819879
Pubmed	Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.	DNM1L LDLR	4.32e-05	4	94	2	28942921
Pubmed	Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.	CDK8 CDK19	4.32e-05	4	94	2	32439758
Pubmed	CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.	ITGAM LDLR	4.32e-05	4	94	2	17372166
Pubmed	Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance.	JAK3 RAG2	4.32e-05	4	94	2	32699230
Pubmed	Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Rα1.	ITGAM LDLR	4.32e-05	4	94	2	26160172
Pubmed	XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1.	POLR2A E2F1	4.32e-05	4	94	2	29973595
Pubmed	BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation.	NF1 POLR2A	4.32e-05	4	94	2	15999204
Pubmed	Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.	CIP2A E2F1	4.32e-05	4	94	2	23306062
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDK8 MSRA TMCO4 PXDN SPATA6 KCNQ5 PPFIA2 CDK19 FRMPD1 NLRC5 VPS54 TNFAIP8 ARHGEF37 ZC3HAV1	4.62e-05	1489	94	14	28611215
Pubmed	Mediator and cohesin connect gene expression and chromatin architecture.	CDK8 MED15 MED23	5.96e-05	28	94	3	20720539
Pubmed	Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme.	POLR2A MED23	7.19e-05	5	94	2	10753860
Pubmed	Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.	JAK3 RAG2	7.19e-05	5	94	2	9858510
Pubmed	CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis.	RAG2 ITGAM	7.19e-05	5	94	2	18250481
Pubmed	Characterization of mediator complexes from HeLa cell nuclear extract.	CDK8 MED23	7.19e-05	5	94	2	11416138
Pubmed	Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.	CDK8 POLR2A	7.19e-05	5	94	2	12145330
Pubmed	A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.	NLRP8 NLRP5	7.19e-05	5	94	2	22166940
Pubmed	Retroviral cyclin enhances cyclin-dependent kinase-8 activity.	CDK8 POLR2A	7.19e-05	5	94	2	22379099
Pubmed	Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.	RAG2 LDLR	7.19e-05	5	94	2	19737863
Pubmed	The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.	CDK8 MED15 MED23	8.14e-05	31	94	3	23322298
Pubmed	Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer.	CDK8 MED15 POLR2A ZC3HAV1	9.81e-05	88	94	4	26318153
Pubmed	Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II.	CDK8 POLR2A	1.08e-04	6	94	2	15009212
Pubmed	The BRCT domain is a phospho-protein binding domain.	POLR2A E2F1	1.08e-04	6	94	2	14576433
Pubmed	Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.	RAG2 NF1	1.08e-04	6	94	2	19111880
Pubmed	Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity.	RAG2 ITGAM	1.08e-04	6	94	2	16177324
Pubmed	The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.	CDK8 MED15	1.08e-04	6	94	2	14983011
Pubmed	Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.	CUL3 RAG2	1.08e-04	6	94	2	26320660
Pubmed	Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.	CDK8 POLR2A	1.08e-04	6	94	2	11278802
Pubmed	CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance.	CDK8 RAG2	1.08e-04	6	94	2	23933255
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK4 PTK2B GBF1 NF1 MDN1 KCNQ5 FRMD6 DNM1L TNPO3 ZC3HAV1	1.14e-04	861	94	10	36931259
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	NEK2 GBF1 MDN1 CIP2A TERF2 TNPO3	1.35e-04	288	94	6	23383273
Pubmed	Factors associated with the mammalian RNA polymerase II holoenzyme.	CDK8 POLR2A	1.50e-04	7	94	2	9443979
Pubmed	Aberrant regulation of imprinted gene expression in Gtl2lacZ mice.	DIO3 DYNC1H1	1.50e-04	7	94	2	16575184
Pubmed	Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution.	RAG2 NF1	1.50e-04	7	94	2	31982409
Pubmed	Proapoptotic function of the retinoblastoma tumor suppressor protein.	POLR2A E2F1	1.50e-04	7	94	2	19249677
Pubmed	Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation.	CDK8 MED23	1.50e-04	7	94	2	18691967
Pubmed	Type-2 innate lymphoid cells control the development of atherosclerosis in mice.	RAG2 LDLR	1.50e-04	7	94	2	28589929
Pubmed	Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.	CDK8 CDK19	1.50e-04	7	94	2	22668559
Interaction	CTDP1 interactions	CDK8 MED15 GBF1 HEATR6 NF1 MDN1 POLR2A E2F1 MED23 IPO11	2.11e-08	207	87	10	int:CTDP1
Interaction	EFNA4 interactions	DOCK4 GBF1 NF1 PXDN CIP2A DNM1L VPS54 TNPO3	9.08e-06	239	87	8	int:EFNA4
Interaction	GYPA interactions	DOCK4 GBF1 HEATR6 NF1 CIP2A DNM1L TNPO3	1.04e-05	174	87	7	int:GYPA
Interaction	MED13L interactions	CDK8 MED15 POLR2A CDK19 MED23	1.39e-05	71	87	5	int:MED13L
Interaction	MED11 interactions	CDK8 MED15 POLR2A CDK19 MED23	1.39e-05	71	87	5	int:MED11
Interaction	TACSTD2 interactions	HEATR6 NF1 MDN1 CIP2A TNPO3 IPO11	2.02e-05	129	87	6	int:TACSTD2
Interaction	GPR182 interactions	GBF1 HEATR6 MDN1 CIP2A MED23 TNPO3 PIGO CYFIP2 SLC4A2 IPO11	2.64e-05	455	87	10	int:GPR182
Interaction	MED18 interactions	CDK8 MED15 POLR2A CDK19 MED23	2.64e-05	81	87	5	int:MED18
Interaction	MED30 interactions	CDK8 MED15 POLR2A CDK19 MED23	3.15e-05	84	87	5	int:MED30
Interaction	MED22 interactions	CDK8 MED15 POLR2A CDK19 MED23	3.34e-05	85	87	5	int:MED22
Interaction	OPALIN interactions	HEATR6 NF1 MDN1 CIP2A TNPO3 SLC4A2 IPO11	3.38e-05	209	87	7	int:OPALIN
Interaction	MED13 interactions	CDK8 MED15 POLR2A CDK19 MED23	3.53e-05	86	87	5	int:MED13
Interaction	CDK19 interactions	CDK8 MED15 POLR2A CDK19 MED23	3.95e-05	88	87	5	int:CDK19
Interaction	MED7 interactions	CDK8 MED15 POLR2A CDK19 MED23	4.89e-05	92	87	5	int:MED7
Interaction	MED12L interactions	CDK8 MED15 CDK19 MED23	5.02e-05	47	87	4	int:MED12L
Interaction	MED25 interactions	CDK8 MED15 POLR2A CDK19 MED23	5.15e-05	93	87	5	int:MED25
Interaction	MED6 interactions	CDK8 MED15 POLR2A CDK19 MED23	7.64e-05	101	87	5	int:MED6
Interaction	MED10 interactions	CDK8 MED15 POLR2A CDK19 MED23	8.00e-05	102	87	5	int:MED10
Interaction	MED29 interactions	CDK8 MED15 POLR2A CDK19 MED23	8.00e-05	102	87	5	int:MED29
Interaction	MED27 interactions	CDK8 MED15 POLR2A CDK19 MED23	8.00e-05	102	87	5	int:MED27
Interaction	MED19 interactions	CDK8 MED15 POLR2A CDK19 MED23	9.61e-05	106	87	5	int:MED19
Interaction	FBXL19 interactions	CDK8 MED15 CUL3 CDK19 MED23	9.61e-05	106	87	5	int:FBXL19
Interaction	STIP1 interactions	USP5 GBF1 MDN1 TRIML2 CIP2A POLR2A DNM1L LDLR TNPO3 FKBP4 DYNC1H1 IPO11 ZC3HAV1 NLRP5	9.78e-05	1006	87	14	int:STIP1
Interaction	MED26 interactions	CDK8 MED15 POLR2A CDK19 MED23	1.00e-04	107	87	5	int:MED26
Interaction	MED9 interactions	CDK8 MED15 POLR2A CDK19 MED23	1.05e-04	108	87	5	int:MED9
Interaction	P2RY8 interactions	GBF1 CIP2A TNPO3 CYFIP2 SLC4A2 IPO11	1.26e-04	179	87	6	int:P2RY8
Interaction	C3orf18 interactions	NF1 MDN1 CIP2A TNPO3 IPO11	1.41e-04	115	87	5	int:C3orf18
Interaction	MED28 interactions	CDK8 MED15 POLR2A CDK19 MED23	1.47e-04	116	87	5	int:MED28
Interaction	MED8 interactions	CDK8 MED15 POLR2A CDK19 MED23	1.79e-04	121	87	5	int:MED8
Interaction	VIPR2 interactions	CIP2A TNPO3 PIGO CYFIP2 SLC4A2 IPO11	1.95e-04	194	87	6	int:VIPR2
Interaction	NPTN interactions	DOCK4 GBF1 HEATR6 MDN1 CIP2A TNPO3 IPO11	2.01e-04	278	87	7	int:NPTN
Interaction	MED31 interactions	CDK8 MED15 POLR2A CDK19 MED23	2.08e-04	125	87	5	int:MED31
Interaction	FAM234A interactions	GBF1 NF1 CIP2A TNPO3 IPO11	2.16e-04	126	87	5	int:FAM234A
Interaction	GPR17 interactions	GBF1 MDN1 CIP2A MED23 TNPO3 SLC4A2 IPO11	2.24e-04	283	87	7	int:GPR17
Interaction	INSIG1 interactions	PXDN RNF139 LDLR PACSIN2 ZC3HAV1	2.24e-04	127	87	5	int:INSIG1
Interaction	CA14 interactions	NF1 CIP2A DNM1L TNPO3	2.52e-04	71	87	4	int:CA14
Interaction	MED15 interactions	CDK8 MED15 CUL3 CDK19 MED23	2.59e-04	131	87	5	int:MED15
Interaction	MASP1 interactions	CUL3 CDK19 LDLR	2.62e-04	29	87	3	int:MASP1
Interaction	HCST interactions	GBF1 NF1 MDN1 CIP2A ZDHHC3 TNPO3	2.62e-04	205	87	6	int:HCST
Interaction	VSIG1 interactions	NF1 MDN1 CIP2A TNPO3	2.66e-04	72	87	4	int:VSIG1
Interaction	ITGB2 interactions	PTK2B MDN1 ITGAM DYNC1H1 IPO11	2.69e-04	132	87	5	int:ITGB2
Interaction	PKHD1L1 interactions	POLR2A TRIM23	2.73e-04	6	87	2	int:PKHD1L1
Cytoband	9q33.2	OR1L6 OR1K1 OR1L4	7.20e-05	39	94	3	9q33.2
GeneFamily	Cyclins\|Mediator complex	CDK8 MED15 CDK19 MED23	5.76e-06	33	65	4	1061
GeneFamily	Olfactory receptors, family 1	OR1L6 OR1F2P OR1K1 OR1L4	1.26e-05	40	65	4	147
GeneFamily	NLR family	NLRC5 NLRP8 NLRP5	9.64e-05	25	65	3	666
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTK2B FRMD6 FRMPD1	7.70e-04	50	65	3	1293
GeneFamily	Armadillo repeat containing\|Importins	TNPO3 IPO11	1.88e-03	18	65	2	596
GeneFamily	Phosphodiesterases	PDE2A PDE6C	3.34e-03	24	65	2	681
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP8 NLRP5	3.62e-03	25	65	2	994
GeneFamily	Cyclin dependent kinases	CDK8 CDK19	3.91e-03	26	65	2	496
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A ZBTB38 PXDN UNC45B PPFIA2 DNASE1L3	2.08e-06	177	94	6	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	COVID-19-T_cells-CD8+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	JAK3 KCNQ5 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	3.04e-06	189	94	6	2c018d6120f65f0b2704b483bc9da1c0984872e3
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 PTK2B KCNQ5 NLRC5 ITGAM CYFIP2	4.21e-06	200	94	6	4f7be296be0cd54cfc62cc93263fde26210c61f4
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A ZBTB38 UNC45B PPFIA2 DNASE1L3	4.10e-05	181	94	5	4df7972f88117108698efd06b124b232f8588981
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADNP2 TNFAIP8 ADGRF1 PIAS2 ZDHHC3	4.10e-05	181	94	5	8fcc9e77fee7c248df26b6c59b10e672242e2084
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A ZBTB38 UNC45B PPFIA2 DNASE1L3	4.10e-05	181	94	5	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE2A FRMD6 PKDREJ DNASE1L3 IPO11	4.43e-05	184	94	5	e5756afa3181186f9b65552b8df5359ef4024bee
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC22A6 DNAH2 DIO3 PIWIL4	4.52e-05	93	94	4	af489f0dd76c3c1a84d164283149f550a7ece91c
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC22A6 DNAH2 DIO3 PIWIL4	4.52e-05	93	94	4	c1d0afcfa37c2dcbb12189b4ce56ae7c4bb7ba30
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC22A6 DNAH2 DIO3 PIWIL4	4.52e-05	93	94	4	0ea74c2820372d60d3804bf2c8bb0d03733dff98
ToppCell	Control-T_cells-CD8+_T_cells\|Control / group, cell type (main and fine annotations)	KCNQ5 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	4.54e-05	185	94	5	02ab64c0166c0646d1d4c6ed110ef0b75a1096d0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	NF1 LNPEP LDLR DYNC1H1 ZC3HAV1	4.91e-05	188	94	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TRAPPC10 BCAR3 ADGRF1 DNASE1L3	4.92e-05	95	94	4	3d6b97576ce4e7a3e495cbc7246ea8c0b2a386f7
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.03e-05	189	94	5	df30478b288084a1bd48f660409dcc784040897c
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MSRA VPS54 TNFAIP8 ITGAM CYFIP2	5.03e-05	189	94	5	94dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.16e-05	190	94	5	2a8de1cf27a9ebc3825cf9e7a489ecd064dfc7f9
ToppCell	Adult-Immune-T_lymphocyte-D175\|Adult / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.29e-05	191	94	5	0b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.29e-05	191	94	5	c7be771543089fc94e5c62fd22f745189642aec3
ToppCell	COVID-19-T_cells\|COVID-19 / group, cell type (main and fine annotations)	JAK3 KCNQ5 TNFAIP8 CYFIP2 ZC3HAV1	5.29e-05	191	94	5	7f64add931b64b8d35836fa6bee9ebab593844d3
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.42e-05	192	94	5	92f141d5ac462f652f405efa73ac6ef751f40ea3
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.42e-05	192	94	5	69a2b04f03a1b82d067018379f7b8a116e954040
ToppCell	Adult-Immune-T_lymphocyte\|Adult / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.56e-05	193	94	5	26df0c4c8a2355dd5503fadd07e368eb9a2bf06a
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.56e-05	193	94	5	b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.69e-05	194	94	5	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	Adult-Immune-T_lymphocyte-D231\|Adult / Lineage, Cell type, age group and donor	JAK3 KCNQ5 NLRC5 TNFAIP8 CYFIP2	5.69e-05	194	94	5	5c1dca33f382f37a7deb23e573578343c3b54986
ToppCell	Immune-T_lymphocyte\|World / Lineage, Cell type, age group and donor	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	5.69e-05	194	94	5	f47fa18c87b35a3960557f8169ff7830dd6ecb80
ToppCell	T_cells-CTLs\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ZBTB38 NLRC5 ITGAM LDLR CYFIP2	6.12e-05	197	94	5	28117cf300e169182571fbad0de1681a484a435a
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 PTK2B KCNQ5 ITGAM CYFIP2	6.27e-05	198	94	5	824461cf44098440ba8bc0df96735423ac65bda1
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-T_reg\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	6.27e-05	198	94	5	7608f67959e1cda7b10e57fd3af2f96216ebe7e9
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	6.42e-05	199	94	5	bc93e5c36ab60b66fb633c954b05d4dc09a7f152
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	6.42e-05	199	94	5	6150b272313d3fbf5ddcb3a8d51862d368220fe2
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNQ5 NLRC5 TNFAIP8 ITGAM CYFIP2	6.42e-05	199	94	5	7d69785717073491b5fb81bf24db0175f86cd0b0
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	6.58e-05	200	94	5	d8459e45a8396a9ee063666a1928c649162c5727
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	6.58e-05	200	94	5	c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	6.58e-05	200	94	5	9de4d6ebb7e9bee5d811519eb05913ef30f70786
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAK3 NLRC5 TNFAIP8 CYFIP2 ZC3HAV1	6.58e-05	200	94	5	dbbc7e16929e744b48017da068479a6046e99cf6
Disease	developmental and epileptic encephalopathy 87 (implicated_via_orthology)	CDK8 CDK19	9.20e-06	2	90	2	DOID:0112221 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	NPBWR1 PDE2A NF1 UNC45B FRMPD1 NLRC5 DIO3 E2F1 BCAR3 PKDREJ DNASE1L3 NLRP8	1.02e-04	1074	90	12	C0006142
Disease	systemic scleroderma	PXDN UNC45B TNPO3 DNASE1L3	1.36e-04	85	90	4	EFO_0000717
Disease	juvenile myelomonocytic leukemia (is_implicated_in)	JAK3 NF1	1.91e-04	7	90	2	DOID:0050458 (is_implicated_in)
Disease	AUTISM, SUSCEPTIBILITY TO, 15	CDK8 POLR2A	2.55e-04	8	90	2	C2677504
Disease	hematologic cancer (implicated_via_orthology)	JAK3 PIAS2	7.02e-04	13	90	2	DOID:2531 (implicated_via_orthology)
Disease	severe combined immunodeficiency (is_implicated_in)	JAK3 RAG2	8.17e-04	14	90	2	DOID:627 (is_implicated_in)
Disease	Generalized hypotonia	CDK8 POLR2A	9.41e-04	15	90	2	C1858120
Disease	Moyamoya Disease	NF1 ABCC6	1.21e-03	17	90	2	C0026654
Disease	Feeding difficulties	CDK8 POLR2A	1.36e-03	18	90	2	C0232466
Disease	Omenn Syndrome	JAK3 RAG2	1.52e-03	19	90	2	C2700553
Disease	Juvenile Myelomonocytic Leukemia	JAK3 NF1	1.52e-03	19	90	2	C0349639
Disease	limited scleroderma	TNPO3 DNASE1L3	1.52e-03	19	90	2	EFO_1001017
Disease	Severe Combined Immunodeficiency	JAK3 RAG2	1.69e-03	20	90	2	C0085110
Disease	axial length measurement	KCNQ5 E2F1 HACD4	1.71e-03	77	90	3	EFO_0005318
Disease	testosterone measurement	DOCK3 DOCK4 PDE2A NF1 KCNQ5 POLR2A DNAH2 MED23 SLC22A24 PKDREJ FKBP4	1.71e-03	1275	90	11	EFO_0004908
Disease	Intellectual Disability	CDK8 NF1 OR5M1 KCNQ5 MED23 DYNC1H1	2.49e-03	447	90	6	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
EHEALLSRLICRMIN	ACCSL	66	Q4AC99
LRMHLFTALQLLCLA	SLC4A2	1161	P04920
MSACREIALLRELKH	CDK19	61	Q9BWU1
ARTLNRLLMHHIRDC	DNM1L	286	O00429
CLDHMQDRRALSLKA	BCAR3	321	O75815
HTRRICMVNIALSLL	ADGRF1	621	Q5T601
LHMLQLCASDIRSRL	ARHGEF37	46	A1IGU5
MTRALCSALRQALLL	ACVR1C	1	Q8NER5
SRRICTIAKHLEAML	FAM200A	116	Q8TCP9
MTLAAIAVHLVRCRS	ADNP2	926	Q6IQ32
AQCMDLAERTLIHLS	RAG2	456	P55895
LRRVAACQADRHSLM	JAK3	221	P52333
LCLMFRVGDLRSSHI	KCNJ9	186	Q92806
MLSATRRACQLLLLH	MSRA	1	Q9UJ68
MRLACADTRVHKTAL	OR10V1	186	Q8NGI7
LRQRMDRLDNLTCHL	MDN1	3296	Q9NU22
LQCLLEKSHMDRERL	LIN37	26	Q96GY3
VMTQLTLALKECHRR	NEK2	116	P51955
RVLDHLLFARTLCMD	MGAM2	506	Q2M2H8
MRLCQSVSLLELLHI	HACD4	61	Q5VWC8
SCLRQSKMLTHLSLA	NLRP8	861	Q86W28
TMLRSLLLHSLRLCA	DIO3	26	P55073
HNMLRCAILTTLIHL	IPO11	616	Q9UI26
GHLDMLCRIKSLQTR	KCNQ5	556	Q9NR82
HRLLLCLLMTSCDLS	PDE2A	796	O00408
RLAHLLQADRCSMFL	PDE6C	86	P51160
TLDRLILCLAMRSHE	MED23	861	Q9ULK4
MIACSIRELHRCLLL	HEATR6	511	Q6AI08
SVHRCMTSRLLQLPD	MED15	751	Q96RN5
MRELRSALLEFACTH	LNPEP	816	Q9UIQ6
LCRSMRLPHCSLQRL	NLRP5	971	P59047
LEINRLTHRLLCKHM	CYFIP2	826	Q96F07
HSLLVGQLMETCARL	NLRC5	1451	Q86WI3
TLALLTHRLSQMTCL	NLRC5	1566	Q86WI3
THRLSQMTCLQSLRL	NLRC5	1571	Q86WI3
ILLMARLSFCASHQV	OR1K1	161	Q8NGR3
LLHTLLMARLSFCAD	OR1F2P	156	Q96R84
RLCSDLMNCLHERAR	PACSIN2	36	Q9UNF0
CPMRSRHLLQLLSNS	FRMD6	306	Q96NE9
DHLMNICTTQLRLLS	E2F1	221	Q01094
LLLSIHSALAMRICS	DNASE1L3	11	Q13609
SCLLSLLRQMCDTHF	DOCK3	946	Q8IZD9
VACLLSLLRQMTDRH	DOCK4	916	Q8N1I0
HLTISTMIGCDRLIR	FBXO15	276	Q8NCQ5
SQKLLSSCRHVIRMD	FRMPD1	1466	Q5SYB0
CIRDHLRQTLLDMIA	CUL3	156	Q13618
SAHNRLMEQLALLCT	DNAAF8	306	Q8IYS4
RRCLAHSLFMSTAEL	DHX33	621	Q9H6R0
FQLEHIMDLTRLRCL	DYNC1H1	2441	Q14204
EMCRHLFQLLSIERL	GBF1	456	Q92538
LNTLCSPMHSRLQRE	CCDC168	1411	Q8NDH2
ALRLASHLNLAMCHL	FKBP4	316	Q02790
MLNLEARRSHLSESC	PTK2B	381	Q14289
MSACREIALLRELKH	CDK8	61	P49336
TMRVTLRDLLRNCHL	DNAH2	1616	Q9P225
RCPTLRHLFLCLSML	SLC22A6	331	Q4U2R8
RLRMHVASLEACAVR	LIPT2	111	A6NK58
LECLVSRHERSLRMT	PPFIA2	141	O75334
LLCRLHAMRLDSHAK	NPBWR1	226	P48145
DLLMRALHLLKSGCS	PIAS2	36	O75928
HSLFRVLLMSRLSFC	OR1L4	156	Q8NGR5
RVLLMSRLSFCASHI	OR1L6	196	Q8NGR2
SSMAQAIRLRLCSVH	MROH5	776	Q6ZUA9
RLSRNMCLLLTAVLH	RNF139	351	Q8WU17
DARARVLVCHMTSLL	TMCO4	131	Q5TGY1
TARCVSLLTLNHMGR	SLC22A24	391	Q8N4F4
CTVLLIAHRLRSVMD	ABCC6	1451	O95255
IAHRLRSVMDCARVL	ABCC6	1456	O95255
GNLCMILLIRTNSHL	OR5M1	41	Q8NGP8
RLQRLSCCLAMLLSS	PKDREJ	1386	Q9NTG1
MDLSICTREKLAHVR	PIWIL4	81	Q7Z3Z4
RNCMSIDALKDLLRH	PRAMEF1	386	O95521
MALRVLLLTALTLCH	ITGAM	1	P11215
NVLSRLLNECREMLH	TNFAIP8	126	O95379
CLMNHERRQTLDLIA	TENT5B	356	Q96A09
LCMAGRDITEHLTRL	ACTRT1	181	Q8TDG2
ELLLAFCSVTQLRHM	CIP2A	301	Q8TCG1
CLALSEDLRTMRLRH	TRIML2	261	Q8N7C3
VILHAVRIDRICSLM	UNC45B	216	Q8IWX7
LAFLALASHCRAMLT	ZDHHC3	86	Q9NYG2
DISCMLKVSRRSLHI	SPO11	156	Q9Y5K1
FNIHLRSTLCSRRMA	POLR2A	1041	P24928
LCFRTTVRCMHLLLE	PXDN	41	Q92626
LRHCTVLAMSNLLNA	NF1	1141	P21359
MALCALTRALRSLNL	MRPL2	1	Q5T653
RFLHDRELQCSVLRM	SERPINA13P	231	Q6UXR4
ANCSVMRFLRDLIHT	TNPO3	791	Q9Y5L0
ACALAASILRRHLMV	PIGO	1026	Q8TEQ8
NCLRSHNLMDRKVLA	ZC3HAV1	186	Q7Z2W4
TTLNRLDRHEQICMR	ZBTB38	381	Q8NAP3
CRNVHMLLRRQESSS	TRAPPC10	696	P48553
IRASILDMAHCIRTF	TRIM23	226	P36406
MCELSEDTRRRLAHL	SPATA6	226	Q9NWH7
EHTVSRLLRVMQCLS	TERF2	136	Q15554
LHLINMVERNCRSSE	USP5	441	P45974
MCEGSLHILRLALTR	VPS54	266	Q9P1Q0
LSQRMICSTQLDRAH	LDLR	446	P01130