Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein kinase A binding	AKAP13 GSK3A GSK3B AKAP7	2.78e-06	58	34	4	GO:0051018
GeneOntologyMolecularFunction	protein kinase A catalytic subunit binding	GSK3A GSK3B	3.33e-04	16	34	2	GO:0034236
GeneOntologyMolecularFunction	cytoskeletal protein binding	PTPN4 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 GSK3A GSK3B SPATA31A7	4.13e-04	1099	34	8	GO:0008092
GeneOntologyMolecularFunction	tau-protein kinase activity	GSK3A GSK3B	6.36e-04	22	34	2	GO:0050321
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	GSK3A GSK3B	7.59e-04	24	34	2	GO:0120283
GeneOntologyMolecularFunction	actin binding	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	1.22e-03	479	34	5	GO:0003779
GeneOntologyMolecularFunction	tau protein binding	GSK3A GSK3B	2.78e-03	46	34	2	GO:0048156
GeneOntologyBiologicalProcess	sexual reproduction	CYLC1 CYLC2 NCAPD3 USP17L2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 GSK3A GSK3B SPATA31A7	4.85e-06	1312	34	11	GO:0019953
GeneOntologyBiologicalProcess	negative regulation of glycogen (starch) synthase activity	GSK3A GSK3B	7.90e-06	3	34	2	GO:2000466
GeneOntologyBiologicalProcess	negative regulation of type B pancreatic cell development	GSK3A GSK3B	7.90e-06	3	34	2	GO:2000077
GeneOntologyBiologicalProcess	gamete generation	CYLC1 CYLC2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 GSK3A GSK3B SPATA31A7	2.16e-05	982	34	9	GO:0007276
GeneOntologyBiologicalProcess	response to interleukin-3	GSK3A GSK3B	5.51e-05	7	34	2	GO:0036015
GeneOntologyBiologicalProcess	cellular response to interleukin-3	GSK3A GSK3B	5.51e-05	7	34	2	GO:0036016
GeneOntologyBiologicalProcess	regulation of glycogen (starch) synthase activity	GSK3A GSK3B	7.34e-05	8	34	2	GO:2000465
GeneOntologyBiologicalProcess	autosome genomic imprinting	GSK3A GSK3B	9.43e-05	9	34	2	GO:0141068
GeneOntologyBiologicalProcess	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GSK3A GSK3B	9.43e-05	9	34	2	GO:1901030
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	CYLC1 CYLC2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 GSK3A GSK3B SPATA31A7	9.95e-05	1194	34	9	GO:0048609
GeneOntologyBiologicalProcess	cell growth involved in cardiac muscle cell development	AKAP13 GSK3A GSK3B	1.07e-04	56	34	3	GO:0061049
GeneOntologyBiologicalProcess	physiological cardiac muscle hypertrophy	AKAP13 GSK3A GSK3B	1.07e-04	56	34	3	GO:0003301
GeneOntologyBiologicalProcess	physiological muscle hypertrophy	AKAP13 GSK3A GSK3B	1.07e-04	56	34	3	GO:0003298
GeneOntologyBiologicalProcess	regulation of type B pancreatic cell development	GSK3A GSK3B	1.18e-04	10	34	2	GO:2000074
GeneOntologyBiologicalProcess	developmental process involved in reproduction	CYLC1 CYLC2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 GSK3A GSK3B SPATA31A7	1.29e-04	1235	34	9	GO:0003006
GeneOntologyBiologicalProcess	mitotic DNA replication checkpoint signaling	CLSPN RAD17	1.44e-04	11	34	2	GO:0033314
GeneOntologyBiologicalProcess	negative regulation of dendrite development	GSK3A GSK3B	1.72e-04	12	34	2	GO:2000171
GeneOntologyBiologicalProcess	negative regulation of glycogen biosynthetic process	GSK3A GSK3B	1.72e-04	12	34	2	GO:0045719
GeneOntologyBiologicalProcess	cell cycle G2/M phase transition	FOXM1 USP17L2 CLSPN RAD17	1.74e-04	171	34	4	GO:0044839
GeneOntologyBiologicalProcess	spermatogenesis	CYLC1 CYLC2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	1.77e-04	744	34	7	GO:0007283
GeneOntologyBiologicalProcess	cellular response to glucocorticoid stimulus	AKAP13 GSK3A GSK3B	1.91e-04	68	34	3	GO:0071385
GeneOntologyBiologicalProcess	male gamete generation	CYLC1 CYLC2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	2.05e-04	762	34	7	GO:0048232
GeneOntologyBiologicalProcess	negative regulation of glycogen metabolic process	GSK3A GSK3B	3.12e-04	16	34	2	GO:0070874
GeneOntologyBiologicalProcess	cellular response to corticosteroid stimulus	AKAP13 GSK3A GSK3B	3.20e-04	81	34	3	GO:0071384
GeneOntologyBiologicalProcess	DNA replication checkpoint signaling	CLSPN RAD17	4.92e-04	20	34	2	GO:0000076
GeneOntologyBiologicalProcess	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GSK3A GSK3B	7.12e-04	24	34	2	GO:1901028
GeneOntologyBiologicalProcess	type B pancreatic cell development	GSK3A GSK3B	1.04e-03	29	34	2	GO:0003323
GeneOntologyBiologicalProcess	cardiac muscle cell development	AKAP13 GSK3A GSK3B	1.06e-03	122	34	3	GO:0055013
GeneOntologyBiologicalProcess	viral protein processing	GSK3A GSK3B	1.27e-03	32	34	2	GO:0019082
GeneOntologyBiologicalProcess	positive regulation of peptidyl-threonine phosphorylation	GSK3A GSK3B	1.27e-03	32	34	2	GO:0010800
GeneOntologyBiologicalProcess	regulation of cell cycle G2/M phase transition	USP17L2 CLSPN RAD17	1.30e-03	131	34	3	GO:1902749
GeneOntologyBiologicalProcess	regulation of carbohydrate biosynthetic process	CYP2J2 GSK3A GSK3B	1.33e-03	132	34	3	GO:0043255
GeneOntologyBiologicalProcess	cardiac cell development	AKAP13 GSK3A GSK3B	1.33e-03	132	34	3	GO:0055006
GeneOntologyBiologicalProcess	mitochondrial outer membrane permeabilization	GSK3A GSK3B	1.35e-03	33	34	2	GO:0097345
GeneOntologyBiologicalProcess	cardiac muscle tissue growth	AKAP13 GSK3A GSK3B	1.51e-03	138	34	3	GO:0055017
GeneOntologyBiologicalProcess	adrenergic receptor signaling pathway	AKAP13 GSK3A	1.52e-03	35	34	2	GO:0071875
GeneOntologyBiologicalProcess	genomic imprinting	GSK3A GSK3B	1.52e-03	35	34	2	GO:0071514
GeneOntologyBiologicalProcess	cardiac muscle hypertrophy	AKAP13 GSK3A GSK3B	1.64e-03	142	34	3	GO:0003300
GeneOntologyBiologicalProcess	striated muscle hypertrophy	AKAP13 GSK3A GSK3B	1.77e-03	146	34	3	GO:0014897
GeneOntologyBiologicalProcess	regulation of glycogen biosynthetic process	GSK3A GSK3B	1.79e-03	38	34	2	GO:0005979
GeneOntologyBiologicalProcess	regulation of glucan biosynthetic process	GSK3A GSK3B	1.79e-03	38	34	2	GO:0010962
GeneOntologyBiologicalProcess	muscle hypertrophy	AKAP13 GSK3A GSK3B	1.84e-03	148	34	3	GO:0014896
GeneOntologyBiologicalProcess	heart growth	AKAP13 GSK3A GSK3B	1.84e-03	148	34	3	GO:0060419
GeneOntologyBiologicalProcess	positive regulation of mitochondrial membrane permeability involved in apoptotic process	GSK3A GSK3B	1.98e-03	40	34	2	GO:1902110
GeneOntologyBiologicalProcess	G2/M transition of mitotic cell cycle	FOXM1 CLSPN RAD17	1.99e-03	152	34	3	GO:0000086
GeneOntologyBiologicalProcess	glycosphingolipid biosynthetic process	ST8SIA3 A3GALT2	2.08e-03	41	34	2	GO:0006688
GeneOntologyBiologicalProcess	type B pancreatic cell differentiation	GSK3A GSK3B	2.18e-03	42	34	2	GO:0003309
GeneOntologyBiologicalProcess	mitochondrial outer membrane permeabilization involved in programmed cell death	GSK3A GSK3B	2.18e-03	42	34	2	GO:1902686
GeneOntologyBiologicalProcess	glandular epithelial cell development	GSK3A GSK3B	2.28e-03	43	34	2	GO:0002068
GeneOntologyBiologicalProcess	response to glucocorticoid	AKAP13 GSK3A GSK3B	2.30e-03	160	34	3	GO:0051384
GeneOntologyBiologicalProcess	G protein-coupled dopamine receptor signaling pathway	GSK3A GSK3B	2.39e-03	44	34	2	GO:0007212
GeneOntologyBiologicalProcess	positive regulation of mitochondrial membrane permeability	GSK3A GSK3B	2.50e-03	45	34	2	GO:0035794
GeneOntologyBiologicalProcess	negative regulation of cardiac muscle hypertrophy	GSK3A GSK3B	2.50e-03	45	34	2	GO:0010614
GeneOntologyBiologicalProcess	regulation of polysaccharide biosynthetic process	GSK3A GSK3B	2.72e-03	47	34	2	GO:0032885
GeneOntologyBiologicalProcess	negative regulation of muscle hypertrophy	GSK3A GSK3B	2.72e-03	47	34	2	GO:0014741
GeneOntologyCellularComponent	acrosomal vesicle	CYLC1 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	9.10e-07	206	34	6	GO:0001669
GeneOntologyCellularComponent	cytoskeletal calyx	CYLC1 CYLC2	7.70e-06	3	34	2	GO:0033150
GeneOntologyCellularComponent	perinuclear theca	CYLC1 CYLC2	2.56e-05	5	34	2	GO:0033011
GeneOntologyCellularComponent	beta-catenin destruction complex	GSK3A GSK3B	1.98e-04	13	34	2	GO:0030877
Domain	DUF4599	SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	3.96e-09	12	33	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	3.96e-09	12	33	4	IPR027970
Domain	CYLC	CYLC1 CYLC2	3.03e-06	2	33	2	IPR026189
Domain	Cylicin_N	CYLC1 CYLC2	3.03e-06	2	33	2	PF15241
Domain	Cylicin_N	CYLC1 CYLC2	3.03e-06	2	33	2	IPR029354
Domain	HABP4_PAI-RBP1	USP17L7 USP17L2	3.58e-04	16	33	2	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L7 USP17L2	3.58e-04	16	33	2	IPR006861
Domain	USP_CS	USP17L7 USP17L2	6.05e-03	66	33	2	IPR018200
Domain	USP_1	USP17L7 USP17L2	6.78e-03	70	33	2	PS00972
Domain	UCH	USP17L7 USP17L2	6.97e-03	71	33	2	PF00443
Domain	USP_2	USP17L7 USP17L2	6.97e-03	71	33	2	PS00973
Domain	USP_3	USP17L7 USP17L2	7.16e-03	72	33	2	PS50235
Domain	USP_dom	USP17L7 USP17L2	7.16e-03	72	33	2	IPR028889
Domain	Peptidase_C19_UCH	USP17L7 USP17L2	7.16e-03	72	33	2	IPR001394
Domain	-	GXYLT1 A3GALT2	8.99e-03	81	33	2	3.90.550.10
Domain	Nucleotide-diphossugar_trans	GXYLT1 A3GALT2	1.05e-02	88	33	2	IPR029044
Pathway	WP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR	FOXM1 XPA CLSPN RAD17	4.57e-06	81	20	4	M39490
Pathway	REACTOME_MATURATION_OF_SARS_COV_1_NUCLEOPROTEIN	GSK3A GSK3B	1.04e-04	11	20	2	M39011
Pathway	WP_GANGLIO_SPHINGOLIPID_METABOLISM	ST8SIA3 A3GALT2	1.48e-04	13	20	2	M39730
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	GSK3A GSK3B	1.72e-04	14	20	2	M3862
Pathway	REACTOME_MATURATION_OF_SARS_COV_2_NUCLEOPROTEIN	GSK3A GSK3B	1.99e-04	15	20	2	M44001
Pathway	PID_BETA_CATENIN_DEG_PATHWAY	GSK3A GSK3B	2.89e-04	18	20	2	M31
Pathway	PID_WNT_CANONICAL_PATHWAY	GSK3A GSK3B	3.58e-04	20	20	2	M90
Pathway	BIOCARTA_PTDINS_PATHWAY	GSK3A GSK3B	4.75e-04	23	20	2	M8809
Pathway	WP_REGULATION_OF_APOPTOSIS_BY_PARATHYROID_HORMONERELATED_PROTEIN	GSK3A GSK3B	5.63e-04	25	20	2	M39533
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER	GSK3A GSK3B	6.09e-04	26	20	2	M27558
Pathway	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	GSK3A GSK3B	6.57e-04	27	20	2	M1718
Pathway	WP_T_CELL_RECEPTOR_AND_COSTIMULATORY_SIGNALING	GSK3A GSK3B	7.07e-04	28	20	2	M39632
Pathway	REACTOME_TRANSLATION_OF_SARS_COV_1_STRUCTURAL_PROTEINS	GSK3A GSK3B	7.59e-04	29	20	2	M39014
Pathway	WP_GLYCOGEN_METABOLISM	GSK3A GSK3B	1.04e-03	34	20	2	MM15985
Pathway	PID_PI3KCI_AKT_PATHWAY	GSK3A GSK3B	1.11e-03	35	20	2	M249
Pathway	REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS	CLSPN RAD17	1.17e-03	36	20	2	MM14687
Pathway	REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS	CLSPN RAD17	1.24e-03	37	20	2	M11153
Pathway	PID_ATR_PATHWAY	CLSPN RAD17	1.37e-03	39	20	2	M46
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	GSK3A GSK3B	1.44e-03	40	20	2	M39595
Pathway	PID_FOXM1_PATHWAY	FOXM1 GSK3A	1.44e-03	40	20	2	M176
Pathway	WP_IL5_SIGNALING	GSK3A GSK3B	1.44e-03	40	20	2	M39392
Pathway	REACTOME_RAS_PROCESSING	USP17L7 USP17L2	1.83e-03	45	20	2	MM15671
Pathway	SIG_BCR_SIGNALING_PATHWAY	GSK3A GSK3B	1.91e-03	46	20	2	M8626
Pathway	WP_WNT_SIGNALING_WP363	GSK3A GSK3B	2.34e-03	51	20	2	M39721
Pathway	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	GSK3A GSK3B	2.34e-03	51	20	2	M7955
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L7 USP17L2 CLSPN	2.36e-03	191	20	3	MM15289
Pathway	REACTOME_CELL_CYCLE	FOXM1 NCAPD3 CLSPN GSK3B RAD17	2.38e-03	694	20	5	M543
Pathway	REACTOME_TRANSLATION_OF_SARS_COV_2_STRUCTURAL_PROTEINS	GSK3A GSK3B	2.91e-03	57	20	2	M41730
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	4.59e-15	6	35	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	4.59e-15	6	35	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31A5 SPATA31A7	3.21e-11	24	35	5	32212159
Pubmed	Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.	FOXM1 GSK3A GSK3B	7.81e-08	9	35	3	26912724
Pubmed	Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.	GSK3A GSK3B	9.84e-07	2	35	2	24523925
Pubmed	Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine.	GSK3A GSK3B	9.84e-07	2	35	2	27284979
Pubmed	Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.	GSK3A GSK3B	9.84e-07	2	35	2	21325041
Pubmed	Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication.	GSK3A GSK3B	9.84e-07	2	35	2	19106108
Pubmed	Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes.	GSK3A GSK3B	9.84e-07	2	35	2	20553816
Pubmed	GSK3: A potential target and pending issues for treatment of Alzheimer's disease.	GSK3A GSK3B	9.84e-07	2	35	2	38946682
Pubmed	Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.	GSK3A GSK3B	9.84e-07	2	35	2	25808536
Pubmed	Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity.	GSK3A GSK3B	9.84e-07	2	35	2	28630333
Pubmed	Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells.	GSK3A GSK3B	9.84e-07	2	35	2	25561726
Pubmed	Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?	GSK3A GSK3B	9.84e-07	2	35	2	14550568
Pubmed	Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation.	GSK3A GSK3B	9.84e-07	2	35	2	16912034
Pubmed	Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice.	GSK3A GSK3B	9.84e-07	2	35	2	26179612
Pubmed	Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction.	GSK3A GSK3B	9.84e-07	2	35	2	25833158
Pubmed	GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs).	GSK3A GSK3B	9.84e-07	2	35	2	22384031
Pubmed	Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes.	GSK3A GSK3B	9.84e-07	2	35	2	9809441
Pubmed	A novel role for GSK3 in the regulation of the processes of human labour.	GSK3A GSK3B	9.84e-07	2	35	2	25550525
Pubmed	Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.	GSK3A GSK3B	9.84e-07	2	35	2	22065737
Pubmed	Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.	GSK3A GSK3B	9.84e-07	2	35	2	19106302
Pubmed	Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.	GSK3A GSK3B	9.84e-07	2	35	2	16757548
Pubmed	GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis.	GSK3A GSK3B	9.84e-07	2	35	2	24984063
Pubmed	Glycogen synthase kinase (GSK) 3 in pregnancy and parturition: a systematic review of literature.	GSK3A GSK3B	9.84e-07	2	35	2	30278798
Pubmed	The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II.	CYLC1 CYLC2	9.84e-07	2	35	2	7737358
Pubmed	Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus.	GSK3A GSK3B	9.84e-07	2	35	2	28244152
Pubmed	Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human.	CYLC1 CYLC2	9.84e-07	2	35	2	38013430
Pubmed	Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.	GSK3A GSK3B	9.84e-07	2	35	2	17543867
Pubmed	Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.	GSK3A GSK3B	9.84e-07	2	35	2	34638997
Pubmed	Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.	GSK3A GSK3B	9.84e-07	2	35	2	16176184
Pubmed	Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development.	GSK3A GSK3B	9.84e-07	2	35	2	19064989
Pubmed	Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.	CLSPN RAD17	9.84e-07	2	35	2	16885023
Pubmed	Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.	GSK3A GSK3B	9.84e-07	2	35	2	22623685
Pubmed	Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired paclitaxel resistance.	GSK3A GSK3B	9.84e-07	2	35	2	21436692
Pubmed	Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3.	GSK3A GSK3B	9.84e-07	2	35	2	22986169
Pubmed	Varicella-zoster virus requires a functional PI3K/Akt/GSK-3alpha/beta signaling cascade for efficient replication.	GSK3A GSK3B	9.84e-07	2	35	2	16934436
Pubmed	Myocardial stress remodelling after regional infarction is independent of glycogen synthase kinase-3 inactivation.	GSK3A GSK3B	9.84e-07	2	35	2	20696171
Pubmed	GSK-3 inhibition: achieving moderate efficacy with high selectivity.	GSK3A GSK3B	9.84e-07	2	35	2	23369789
Pubmed	The role of glycogen synthase kinase 3 in the early stages of Alzheimers' disease.	GSK3A GSK3B	9.84e-07	2	35	2	18955053
Pubmed	Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3.	GSK3A GSK3B	9.84e-07	2	35	2	20552232
Pubmed	GSK-3 parameters in lymphocytes of schizophrenic patients.	GSK3A GSK3B	9.84e-07	2	35	2	12379450
Pubmed	Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity.	GSK3A GSK3B	9.84e-07	2	35	2	20113358
Pubmed	Isoform- and Cell Type-Specific Roles of Glycogen Synthase Kinase 3 N-Terminal Serine Phosphorylation in Liver Ischemia Reperfusion Injury.	GSK3A GSK3B	9.84e-07	2	35	2	32680958
Pubmed	Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response.	GSK3A GSK3B	9.84e-07	2	35	2	18500637
Pubmed	Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos.	GSK3A GSK3B	9.84e-07	2	35	2	16941690
Pubmed	Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism.	FOXM1 GSK3B	9.84e-07	2	35	2	32813289
Pubmed	Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle.	GSK3A GSK3B	9.84e-07	2	35	2	12086949
Pubmed	Pivotal roles of glycogen synthase-3 in hepatocellular carcinoma.	GSK3A GSK3B	9.84e-07	2	35	2	28619606
Pubmed	Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.	GSK3A GSK3B	9.84e-07	2	35	2	18583716
Pubmed	Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle.	GSK3A GSK3B	9.84e-07	2	35	2	18003720
Pubmed	Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis.	GSK3A GSK3B	9.84e-07	2	35	2	31607568
Pubmed	Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells.	GSK3A GSK3B	9.84e-07	2	35	2	25833708
Pubmed	Glycogen synthase kinase-3 overexpression replicates electroretinogram anomalies of offspring at high genetic risk for schizophrenia and bipolar disorder.	GSK3A GSK3B	9.84e-07	2	35	2	24138923
Pubmed	Elevated O-GlcNAcylation stabilizes FOXM1 by its reduced degradation through GSK-3β inactivation in a human gastric carcinoma cell line, MKN45 cells.	FOXM1 GSK3B	9.84e-07	2	35	2	29196265
Pubmed	GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1.	GSK3A GSK3B	9.84e-07	2	35	2	24397546
Pubmed	Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3.	GSK3A GSK3B	9.84e-07	2	35	2	25788881
Pubmed	Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability.	GSK3A GSK3B	9.84e-07	2	35	2	27841351
Pubmed	A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.	GSK3A GSK3B	9.84e-07	2	35	2	20080974
Pubmed	The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death.	GSK3A GSK3B	9.84e-07	2	35	2	18195042
Pubmed	Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles.	GSK3A GSK3B	9.84e-07	2	35	2	8725894
Pubmed	Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle.	GSK3A GSK3B	9.84e-07	2	35	2	36209826
Pubmed	PKB/SGK-dependent GSK3-phosphorylation in the regulation of LPS-induced Ca2+ increase in mouse dendritic cells.	GSK3A GSK3B	9.84e-07	2	35	2	23817039
Pubmed	AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes.	GSK3A GSK3B	9.84e-07	2	35	2	22814108
Pubmed	GSK3β isoform-selective regulation of depression, memory and hippocampal cell proliferation.	GSK3A GSK3B	9.84e-07	2	35	2	26749572
Pubmed	Distinct expression and activity of GSK-3α and GSK-3β in prostate cancer.	GSK3A GSK3B	9.84e-07	2	35	2	22539113
Pubmed	Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies.	GSK3A GSK3B	9.84e-07	2	35	2	35681507
Pubmed	Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation.	GSK3A GSK3B	9.84e-07	2	35	2	19520363
Pubmed	Role of PKB/SGK-dependent phosphorylation of GSK-3α/β in vascular calcification during cholecalciferol overload in mice.	GSK3A GSK3B	9.84e-07	2	35	2	30119888
Pubmed	Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.	GSK3A GSK3B	9.84e-07	2	35	2	23606540
Pubmed	Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.	GSK3A GSK3B	9.84e-07	2	35	2	25724980
Pubmed	Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3.	GSK3A GSK3B	9.84e-07	2	35	2	17548347
Pubmed	Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.	GSK3A GSK3B	9.84e-07	2	35	2	23621307
Pubmed	Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells.	GSK3A GSK3B	9.84e-07	2	35	2	19858210
Pubmed	Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.	GSK3A GSK3B	9.84e-07	2	35	2	20299330
Pubmed	Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa.	GSK3A GSK3B	9.84e-07	2	35	2	29574946
Pubmed	Dynamic range of GSK3α not GSK3β is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses.	GSK3A GSK3B	9.84e-07	2	35	2	25208523
Pubmed	Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination.	GSK3A GSK3B	9.84e-07	2	35	2	27053198
Pubmed	Glycogen synthase kinase 3: more than a namesake.	GSK3A GSK3B	9.84e-07	2	35	2	19366350
Pubmed	Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice.	GSK3A GSK3B	9.84e-07	2	35	2	21502951
Pubmed	Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.	GSK3A GSK3B	9.84e-07	2	35	2	20357757
Pubmed	GSK3 alpha and GSK3 beta are necessary for axon formation.	GSK3A GSK3B	9.84e-07	2	35	2	17391670
Pubmed	Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain.	GSK3A GSK3B	9.84e-07	2	35	2	20831597
Pubmed	Proteinuria in mice expressing PKB/SGK-resistant GSK3.	GSK3A GSK3B	9.84e-07	2	35	2	18987114
Pubmed	Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development.	GSK3A GSK3B	9.84e-07	2	35	2	23167932
Pubmed	Differential regulation of STAT family members by glycogen synthase kinase-3.	GSK3A GSK3B	9.84e-07	2	35	2	18550525
Pubmed	Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death.	GSK3A GSK3B	9.84e-07	2	35	2	20920357
Pubmed	GSK-3 is an RNA polymerase II phospho-CTD kinase.	GSK3A GSK3B	9.84e-07	2	35	2	32374842
Pubmed	Glycogen synthase kinase 3 in chronic rhinosinusitis: two faces of a single enzyme in one disease.	GSK3A GSK3B	9.84e-07	2	35	2	23352529
Pubmed	Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture.	GSK3A GSK3B	9.84e-07	2	35	2	30578291
Pubmed	Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway.	GSK3A GSK3B	9.84e-07	2	35	2	29642012
Pubmed	Characterizing the Role of Glycogen Synthase Kinase-3α/β in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways in Cultured Ldlr-/- Macrophages.	GSK3A GSK3B	9.84e-07	2	35	2	34394077
Pubmed	Expression and regulation of glycogen synthase kinase 3 in human neutrophils.	GSK3A GSK3B	9.84e-07	2	35	2	24035907
Pubmed	Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells.	GSK3A GSK3B	2.95e-06	3	35	2	21191064
Pubmed	Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.	GSK3A GSK3B	2.95e-06	3	35	2	25935310
Pubmed	Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy.	GSK3A GSK3B	2.95e-06	3	35	2	30745182
Pubmed	Dopamine D3 receptor and GSK3β signaling mediate deficits in novel object recognition memory within dopamine transporter knockdown mice.	GSK3A GSK3B	2.95e-06	3	35	2	31900153
Pubmed	GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia.	GSK3A GSK3B	2.95e-06	3	35	2	26766591
Pubmed	Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle.	GSK3A GSK3B	2.95e-06	3	35	2	21035757
Pubmed	Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3α/β dependent mechanism.	GSK3A GSK3B	2.95e-06	3	35	2	21130869
Interaction	HELB interactions	CLSPN GSK3A GSK3B	8.98e-06	25	33	3	int:HELB
Interaction	USP17L7 interactions	USP17L7 USP17L2	3.88e-05	6	33	2	int:USP17L7
Interaction	TBC1D8 interactions	TRAF4 GSK3A GSK3B	8.37e-05	52	33	3	int:TBC1D8
Interaction	STON1 interactions	GSK3A GSK3B	9.29e-05	9	33	2	int:STON1
Interaction	ACR interactions	GSK3A GSK3B	1.16e-04	10	33	2	int:ACR
Interaction	USP17L9P interactions	USP17L7 USP17L2	1.16e-04	10	33	2	int:USP17L9P
Interaction	SCML1 interactions	PTPN4 GSK3A GSK3B	1.22e-04	59	33	3	int:SCML1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A5 SPATA31A7	1.58e-05	8	35	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	1.54e-04	24	35	2	9p13.1
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP13 AKAP7	3.74e-04	29	18	2	396
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXM1 NCAPD3 CLSPN	2.81e-04	163	35	3	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXM1 TRAF4 CLSPN	2.86e-04	164	35	3	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	367C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TRAF4 CYP2J2 PLD4	2.86e-04	164	35	3	95b800c78871354c859abaa832d778786ef7bcc0
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXM1 TRAF4 CLSPN	2.86e-04	164	35	3	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	3.01e-04	167	35	3	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	(3)_MNP-(3)_DC_plasmacytoid\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	TRAF4 CYP2J2 PLD4	3.07e-04	168	35	3	13c160ea1a19b47d2e7e2dae818c8dcde4e3e377
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXM1 NCAPD3 CLSPN	3.12e-04	169	35	3	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 CLSPN PLD4	3.23e-04	171	35	3	55c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXM1 NCAPD3 CLSPN	3.28e-04	172	35	3	2b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 NCAPD3 CLSPN	3.28e-04	172	35	3	e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	TRAF4 CYP2J2 PLD4	3.28e-04	172	35	3	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK\|bone_marrow / Manually curated celltypes from each tissue	FOXM1 NCAPD3 CLSPN	3.34e-04	173	35	3	8a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 TRAF4 CLSPN	3.34e-04	173	35	3	31784679190fbd95fc23d7c66008eb21b8c7cc5d
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CLSPN CPED1 PLD4	3.34e-04	173	35	3	9c7386bf0a899882c733f0b4921a96afde032a7d
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 NCAPD3 CLSPN	3.34e-04	173	35	3	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CLSPN CPED1 PLD4	3.34e-04	173	35	3	a55f310c533432e9e26e400026a5b47245152976
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 NCAPD3 CLSPN	3.34e-04	173	35	3	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	3.40e-04	174	35	3	84da9faff088d05233183b425385beb054c92d1b
ToppCell	Dividing_Macrophages-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	FOXM1 NCAPD3 CLSPN	3.45e-04	175	35	3	0a8bf455babb3271aa00642199fb58b0b02dc3ac
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	3.45e-04	175	35	3	876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T\|Lung / Manually curated celltypes from each tissue	FOXM1 NCAPD3 CLSPN	3.51e-04	176	35	3	a40dfd8c4ba16757ff929b2f03a0628acf334de4
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_1\|367C / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 CLSPN PLD4	3.57e-04	177	35	3	ba701d3c90722d8bff70d0fa651899305cdad257
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXM1 NCAPD3 CLSPN	3.69e-04	179	35	3	54191c00b29f53b520cd3243b5791daa4a2c72d7
ToppCell	mild-Myeloid-pDC\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TRAF4 CPED1 PLD4	3.75e-04	180	35	3	38614155fa537d0defda914c531c697be0ef06d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	3.75e-04	180	35	3	401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	3.75e-04	180	35	3	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRAF4 CYP2J2 COL28A1	3.87e-04	182	35	3	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAD51AP2 NCAPD3 CLSPN	3.87e-04	182	35	3	e6968e0bd9cef92052d04ac54e2dd746b37623f6
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	3.94e-04	183	35	3	769a022fe8568ec49e66f792cc5777e713a7571c
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	3.94e-04	183	35	3	aac0695fafa59cabd920ee18b1139d3e00d898e8
ToppCell	Mild/Remission-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	USP17L7 AKAP13 PLD4	4.00e-04	184	35	3	3d4864605c812862cf8926e02370eea3b8ccf32f
ToppCell	Dividing_Macrophages-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	FOXM1 NCAPD3 CLSPN	4.00e-04	184	35	3	f15ce786d25c6546804a6d1efcc2ad645f2ef54e
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXM1 NCAPD3 CLSPN	4.06e-04	185	35	3	89b85ce8026dc80c1bd9f76dfe16401c173b7946
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM132C TRAF4 CYP2J2	4.06e-04	185	35	3	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FOXM1 NCAPD3 CLSPN	4.06e-04	185	35	3	9d424a8608b339dd6129c58d87626678d4ec4af7
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Proliferating_T_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXM1 NCAPD3 CLSPN	4.06e-04	185	35	3	0e0f043ad6d2a62cd47ce39911ad81feab4a4d7e
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	FOXM1 CLSPN PLD4	4.06e-04	185	35	3	9d3168c7f0b1d739f78b368969cf5c77ce202b97
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM132C TRAF4 CYP2J2	4.06e-04	185	35	3	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 TRAF4 CLSPN	4.19e-04	187	35	3	4d12c70c8ed922fbc8f7b139145611203735cab4
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	TRAF4 CPED1 PLD4	4.19e-04	187	35	3	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	4.19e-04	187	35	3	057569c9437219ecc396aa6e673b1178a2273837
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 TRAF4 CLSPN	4.19e-04	187	35	3	e851ee46a6b4068a7bd7602ee183c0ace50ee4dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 TRAF4 CLSPN	4.19e-04	187	35	3	e46b49b4053d2d0f3e1d2bcdc380f7f8733cbe07
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	TRAF4 CPED1 PLD4	4.19e-04	187	35	3	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP17L7 TRAF4 PLD4	4.26e-04	188	35	3	18d16e3f095a109b6a690f46fe7fcd5674c3636b
ToppCell	droplet-Marrow-BM-30m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAPD3 TRAF4 CLSPN	4.26e-04	188	35	3	f1a9d8ea174a4bef0fae8188e3bd96b7ac1a39bb
ToppCell	3'_v3-Lung-Myeloid_Dendritic-Cycling_Dendritic\|Lung / Manually curated celltypes from each tissue	FOXM1 CLSPN PLD4	4.26e-04	188	35	3	0e8ac42c439f30a05e015210e1d5c2dcb9d9d471
ToppCell	NS-critical-d_0-4-Lymphoid-NKT-proliferating\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FOXM1 NCAPD3 CLSPN	4.33e-04	189	35	3	d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAPD3 TRAF4 CLSPN	4.33e-04	189	35	3	3ade3fa9369e85304b20d7233b581f18ad5ecc89
ToppCell	Dividing_Macrophages-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	FOXM1 NCAPD3 CLSPN	4.33e-04	189	35	3	d4e88a3e50499d683e3db38aee04490146fe30bb
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXM1 NCAPD3 CLSPN	4.33e-04	189	35	3	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAPD3 TRAF4 CLSPN	4.33e-04	189	35	3	16dfc37d8d390ed7f927bc844c47c9c5a89a0928
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	4.39e-04	190	35	3	31de1727822e9818652946dfb962daee77ffad68
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	TRAF4 CPED1 PLD4	4.39e-04	190	35	3	6892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FOXM1 NCAPD3 CLSPN	4.39e-04	190	35	3	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	Endothelial-D_(cycle)\|World / shred on cell class and cell subclass (v4)	FOXM1 NCAPD3 CLSPN	4.46e-04	191	35	3	49a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Cycling_Myeloid-Mac\|GI_small-bowel / Manually curated celltypes from each tissue	FOXM1 CLSPN PLD4	4.46e-04	191	35	3	c3944332c5226b0113f8aa9ac07837b755606c6c
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T\|bone_marrow / Manually curated celltypes from each tissue	FOXM1 NCAPD3 CLSPN	4.46e-04	191	35	3	210a0f1a71df2508cbfc73d6868a2122338b9a1c
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	FOXM1 CLSPN PLD4	4.46e-04	191	35	3	aa9c0b1b90cdb7a95d4e6332819f82cae0a79ff9
ToppCell	Mild-T/NK_proliferative\|World / Disease group and Cell class	FOXM1 NCAPD3 CLSPN	4.46e-04	191	35	3	9dba5526fd5ea8065ad305feb2ee562335f887c6
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l12-14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXM1 NCAPD3 CLSPN	4.53e-04	192	35	3	52d0aa51e3b6ab3608a5f40bdde9f8134b3afd94
ToppCell	droplet-Tongue-nan-24m-Epithelial-proliferating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	4.60e-04	193	35	3	f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCell	P07-Endothelial-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXM1 NCAPD3 CLSPN	4.60e-04	193	35	3	1e95ef29357969ee385b4717c0b5a497390ac260
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-Cycling_T\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FOXM1 NCAPD3 CLSPN	4.60e-04	193	35	3	bec113472c40c0106a9427248cbcf54548797596
ToppCell	Severe_COVID-19-Myeloid-proliferating_Myeloid_cells\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FOXM1 CLSPN CPED1	4.60e-04	193	35	3	0d85025690c9cd545cba30abc38acbdd6a39b153
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXM1 NCAPD3 CLSPN	4.60e-04	193	35	3	e45ce9cf8421512b57f157c24b64793b47b4ba4b
ToppCell	P07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXM1 NCAPD3 CLSPN	4.60e-04	193	35	3	0f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FOXM1 NCAPD3 CLSPN	4.60e-04	193	35	3	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	P03-Endothelial-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXM1 NCAPD3 CLSPN	4.67e-04	194	35	3	22bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FOXM1 CLSPN CPED1	4.67e-04	194	35	3	cb39850e9577015b6b9834e98c36b412bae7d462
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FOXM1 CLSPN CPED1	4.67e-04	194	35	3	408597c9aa302a44b112c1d612c21fbb0227a82a
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FOXM1 CLSPN CPED1	4.67e-04	194	35	3	193cc20fefbd795a4ad59e401a95af47d30603e7
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 NCAPD3 CLSPN	4.67e-04	194	35	3	4c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCell	P03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXM1 NCAPD3 CLSPN	4.67e-04	194	35	3	5e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCell	BAL-Severe-Myeloid-Myeloid\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FOXM1 CLSPN CPED1	4.67e-04	194	35	3	2360b5f995b360419de41612368cab9fb61781a1
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FOXM1 NCAPD3 CLSPN	4.67e-04	194	35	3	f9070035553bc68106a9e0bdf4b507715a138aba
ToppCell	Control-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	TRAF4 CPED1 PLD4	4.67e-04	194	35	3	5f95a5a35f73222dbe2ca52cc580f4774f641403
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FOXM1 CLSPN CPED1	4.67e-04	194	35	3	903ae11708b0cb24538c6982abd57fe6fa95b8d3
ToppCell	(1)_T_cells_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FOXM1 NCAPD3 CLSPN	4.67e-04	194	35	3	8f313071933451780309d2174ed27d8cdc734343
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating\|367C / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 NCAPD3 CLSPN	4.67e-04	194	35	3	a12b64945e10f00aa983678a02586c59badc1570
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	TRAF4 SF3B2 AKAP7	4.67e-04	194	35	3	4903a0d6e36599bcb83b179462e5b949df9eb685
ToppCell	BAL-Severe-Myeloid-Myeloid\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FOXM1 CLSPN CPED1	4.67e-04	194	35	3	58406502a8cbcc3037f79a1b6a683df408297ae5
ToppCell	COVID-19-T_cells-Cycling_NK/T_cells\|COVID-19 / group, cell type (main and fine annotations)	FOXM1 NCAPD3 CLSPN	4.74e-04	195	35	3	764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell	(1)_T_cells-(1)_T_cells_Dividing\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	FOXM1 NCAPD3 CLSPN	4.74e-04	195	35	3	cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-proliferating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	4.74e-04	195	35	3	b57132802cb977551e214880984f3edcd375474f
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXM1 NCAPD3 CLSPN	4.74e-04	195	35	3	5790b47b0e028e49b99bda8d6d9e80ac79208cdf
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	4.74e-04	195	35	3	7ae732f100e9a3c6062be5b877efa1ec9d5b3958
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	4.74e-04	195	35	3	5749ea833be84e262e3d0a4fe1a9a373f0ef545f
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	4.74e-04	195	35	3	294c74336fafc1bad237d851efb4a487475078eb
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 CLSPN PLD4	4.74e-04	195	35	3	47a01b8a92eebeb34ac7f70bf1ab4613a326e24f
ToppCell	343B-Myeloid-Dendritic\|343B / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 CLSPN PLD4	4.81e-04	196	35	3	fdb4f7e757b30b974ed3cd80c47beb4557a70845
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	34bd155e6d848eb53d613997c0e244535de30ba3
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	9591a6a3477ed6a1e2e016f7542e38603d8b16cb
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	0644bd14a944b9c9759a295dfdd5e67a4775f20a
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	20383d576708b7e4bfce3e9fe40548cce496e3cb
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	36ed1918f70b6f5760bb088b15ce422998055cc7
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	1964c5003a0cb84539850a7cfe3bbb0e23a61d2d
ToppCell	severe-T/NK_proliferative\|severe / disease stage, cell group and cell class	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	89f005216770dbb84378f5d1f20ca11b0ce40faa
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXM1 NCAPD3 CLSPN	4.81e-04	196	35	3	5ddd314d3def3776dc7da83778d41c6436ca51ac
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FOXM1 NCAPD3 CLSPN	4.88e-04	197	35	3	434a5686a103bb766e0d80038413f0e12ea3981a
Drug	xestomanzamine A	GSK3A GSK3B	1.79e-06	2	31	2	CID006481130
Drug	ircinal	GSK3A GSK3B	1.79e-06	2	31	2	CID005270588
Drug	(-)-Ircinol A	GSK3A GSK3B	1.79e-06	2	31	2	CID005276610
Drug	AC1L8KDY	GSK3A GSK3B	1.79e-06	2	31	2	CID000382949
Drug	manzamine A N-oxide	GSK3A GSK3B	1.79e-06	2	31	2	CID006480355
Drug	Me-6-BIO	GSK3A GSK3B	1.79e-06	2	31	2	CID006538821
Drug	Resveratrol [501-36-0]; Down 200; 17.6uM; PC3; HT_HG-U133A	CYLC1 AKAP13 TRAF4 HOXC13 CPED1	5.33e-06	189	31	5	5084_DN
Drug	5-benzyloxyindole	GSK3A GSK3B	5.38e-06	3	31	2	CID000014624
Drug	nitroguanil	GSK3A GSK3B	5.38e-06	3	31	2	CID000005822
Drug	2-amino-5-nitrothiazole	GSK3A GSK3B	1.07e-05	4	31	2	CID000008486
Drug	5 mi	GSK3A GSK3B	1.07e-05	4	31	2	CID000011978
Drug	NSC717830	GSK3A GSK3B	1.07e-05	4	31	2	CID005472313
Drug	GSK-3 inhibitor II	GSK3A GSK3B	1.07e-05	4	31	2	CID006539732
Drug	AC1L9IAC	GSK3A GSK3B	1.07e-05	4	31	2	CID000445613
Drug	L 442	GSK3A GSK3B	1.79e-05	5	31	2	CID000069369
Drug	Akt inhibitor X	GSK3A GSK3B	1.79e-05	5	31	2	CID010521421
Drug	AC1L8KDV	GSK3A GSK3B	1.79e-05	5	31	2	CID000382948
Drug	3-isothiocyanatobutanal	GSK3A GSK3B	1.79e-05	5	31	2	CID011355490
Drug	propiconazole	CYLC1 GSK3A GSK3B	2.35e-05	41	31	3	CID000043234
Drug	DHED	GSK3A GSK3B	2.68e-05	6	31	2	CID000131331
Drug	2-methylthioadenosine diphosphate trisodium	AKAP13 GSK3A GSK3B	4.83e-05	52	31	3	CID000001579
Drug	Wnt agonist	GSK3A GSK3B	5.00e-05	8	31	2	CID011210285
Drug	GC-MPT	GSK3A GSK3B	6.42e-05	9	31	2	CID000194264
Drug	2-mercaptopyrimidine	GSK3A GSK3B	6.42e-05	9	31	2	CID001550489
Drug	AC1N4HBY	GSK3A GSK3B	6.42e-05	9	31	2	CID004128835
Drug	deltaMID	GSK3A GSK3B	6.42e-05	9	31	2	CID000192085
Drug	rhenium hexafluoride	GSK3A GSK3B	6.42e-05	9	31	2	CID000066231
Drug	1,2,4-thiadiazole	GSK3A GSK3B	8.02e-05	10	31	2	CID006451464
Drug	DMHF	GSK3A GSK3B	8.02e-05	10	31	2	CID003080741
Drug	HMS3267E16	AKAP13 GSK3A GSK3B	8.19e-05	62	31	3	CID000003668
Drug	GW2974	GSK3A GSK3B	9.79e-05	11	31	2	CID006603857
Drug	glycogen phosphorylase inhibitor	GSK3A GSK3B	9.79e-05	11	31	2	CID010070301
Drug	L-690,330	GSK3A GSK3B	9.79e-05	11	31	2	CID000132449
Drug	Bz 48	GSK3A GSK3B	9.79e-05	11	31	2	CID005497206
Drug	IC 87114	GSK3A GSK3B	9.79e-05	11	31	2	ctd:C477872
Drug	NSC-695672	AKAP13 GSK3A GSK3B	1.03e-04	67	31	3	CID000393593
Drug	K00543	GSK3A GSK3B	1.17e-04	12	31	2	CID006419762
Drug	pppAp	GSK3A GSK3B	1.39e-04	13	31	2	CID000189064
Drug	Ruthenium	GSK3A GSK3B	1.39e-04	13	31	2	ctd:D012428
Drug	aloisine A	GSK3A GSK3B	1.39e-04	13	31	2	CID005326843
Drug	5-methoxyindole	GSK3A GSK3B	1.39e-04	13	31	2	CID000013872
Drug	beta-estradiol-3,17-dipropionate	GSK3A GSK3B	1.39e-04	13	31	2	CID000003265
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; PC3; HT_HG-U133A	TRAF4 ST8SIA3 GSK3A AKAP7	1.40e-04	196	31	4	6863_DN
Drug	Nialamide [51-12-7]; Down 200; 13.4uM; PC3; HT_HG-U133A	TRAF4 CYP2J2 CPED1 MCM3AP	1.40e-04	196	31	4	3790_DN
Drug	Norethynodrel [68-23-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A	CYLC1 AKAP13 HOXC13 AKAP7	1.40e-04	196	31	4	1696_DN
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	TRAF4 ST8SIA3 GSK3A AKAP7	1.42e-04	197	31	4	6867_DN
Drug	Haloperidol [52-86-8]; Up 200; 10.6uM; PC3; HG-U133A	AKAP13 METTL17 GSK3A MCM3AP	1.45e-04	198	31	4	1955_UP
Drug	Oxytetracycline dihydrate [6153-64-6]; Down 200; 8uM; HL60; HG-U133A	AKAP13 XPA SF3B2 MCM3AP	1.45e-04	198	31	4	1553_DN
Drug	SC-560; Down 200; 10uM; PC3; HT_HG-U133A	TRAF4 ST8SIA3 GSK3A AKAP7	1.45e-04	198	31	4	6865_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	TRAF4 HOXC13 CPED1 MCM3AP	1.48e-04	199	31	4	4526_DN
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; HL60; HT_HG-U133A	AKAP13 TRAF4 CYP2J2 ST8SIA3	1.48e-04	199	31	4	2461_UP
Drug	thiadiazolidinone	GSK3A GSK3B	1.62e-04	14	31	2	CID000443041
Drug	MS10	GSK3A GSK3B	1.86e-04	15	31	2	CID007926288
Drug	1uu9	GSK3A GSK3B	2.13e-04	16	31	2	CID000002398
Drug	naphthaldehyde	GSK3A GSK3B	2.13e-04	16	31	2	CID000006195
Drug	AC1L1GZ2	GSK3A GSK3B	2.13e-04	16	31	2	CID000003905
Drug	ZSTK474	GSK3A GSK3B	2.41e-04	17	31	2	CID011647372
Drug	M40401	GSK3A GSK3B	2.41e-04	17	31	2	CID000503947
Drug	SBHA	GSK3A GSK3B	2.41e-04	17	31	2	CID000005173
Drug	AT-8	GSK3A GSK3B	2.41e-04	17	31	2	CID000025566
Drug	4-methylene-2-octyl-5-oxofuran-3-carboxylic acid	GSK3A GSK3B	2.41e-04	17	31	2	ctd:C406734
Drug	splitomicin	GSK3A GSK3B	2.41e-04	17	31	2	CID000005269
Drug	grifolin	GSK3A GSK3B	2.41e-04	17	31	2	CID005372312
Drug	chlorin e6	GSK3A GSK3B	2.71e-04	18	31	2	CID005360596
Drug	Ruthenium Compounds	GSK3A GSK3B	2.71e-04	18	31	2	ctd:D017975
Drug	DCFH	GSK3A GSK3B	3.02e-04	19	31	2	CID000077718
Drug	AC1LAJUZ	GSK3A GSK3B	3.02e-04	19	31	2	CID000489569
Drug	Akti-1/2	GSK3A GSK3B	3.02e-04	19	31	2	CID010196499
Drug	1-azakenpaullone	GSK3A GSK3B	3.02e-04	19	31	2	CID006538897
Drug	paullone	GSK3A GSK3B	3.36e-04	20	31	2	CID000369401
Drug	BADS	GSK3A GSK3B	3.36e-04	20	31	2	CID005706730
Drug	G-V-D	GSK3A GSK3B	3.36e-04	20	31	2	CID016040294
Drug	A-443654	GSK3A GSK3B	3.36e-04	20	31	2	CID010172943
Drug	meisoindigo	GSK3A GSK3B	3.36e-04	20	31	2	CID005479433
Drug	(3Z)-3-[3-(hydroxyamino)indolin-2-ylidene]oxindole	GSK3A GSK3B	3.71e-04	21	31	2	CID016073041
Drug	Bi-O	GSK3A GSK3B	3.71e-04	21	31	2	CID005287844
Drug	AC1Q6BAJ	GSK3A GSK3B	3.71e-04	21	31	2	CID000125675
Drug	HMR 1098	GSK3A GSK3B	4.07e-04	22	31	2	CID003037766
Drug	AC1O0B8G	FOXM1 NCAPD3 GSK3A GSK3B	4.22e-04	262	31	4	CID000091605
Drug	bis(maltolato)oxovanadium(IV	GSK3A GSK3B	4.46e-04	23	31	2	CID003035454
Drug	NSC 680410	GSK3A GSK3B	4.46e-04	23	31	2	ctd:C404397
Drug	MRS1191	GSK3A GSK3B	4.46e-04	23	31	2	CID000393594
Drug	PHA665752	GSK3A GSK3B	4.46e-04	23	31	2	CID010461815
Drug	Akt inhibitor IV	GSK3A GSK3B	4.86e-04	24	31	2	CID002326992
Drug	AC1LARMV	GSK3A GSK3B	5.71e-04	26	31	2	CID000493817
Drug	lonafarnib	GSK3A GSK3B	5.71e-04	26	31	2	ctd:C115354
Drug	KNK437	GSK3A GSK3B	5.71e-04	26	31	2	CID009859662
Drug	6-bromoindirubin-3'-oxime	GSK3A GSK3B	6.17e-04	27	31	2	ctd:C483321
Drug	bisindolylmaleimide V	GSK3A GSK3B	6.63e-04	28	31	2	CID000002400
Drug	MRS1523	GSK3A GSK3B	6.63e-04	28	31	2	CID003661570
Drug	S-ethylcysteine	GSK3A GSK3B	6.63e-04	28	31	2	CID000030993
Drug	indirubin-3'-monoxime	GSK3A GSK3B	7.12e-04	29	31	2	CID005326739
Disease	amyotrophic lateral sclerosis (is_implicated_in)	GSK3A GSK3B	5.20e-04	32	31	2	DOID:332 (is_implicated_in)
Disease	Depression, Neurotic	GSK3A GSK3B	8.54e-04	41	31	2	C0282126
Disease	Melancholia	GSK3A GSK3B	8.54e-04	41	31	2	C0025193
Disease	Depressive Syndrome	GSK3A GSK3B	8.96e-04	42	31	2	C0086133
Disease	Endogenous depression	GSK3A GSK3B	1.07e-03	46	31	2	C0011573
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L7 USP17L2	1.07e-03	46	31	2	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L7 USP17L2	2.40e-03	69	31	2	DOID:1682 (implicated_via_orthology)
Disease	Manic Disorder	GSK3A GSK3B	2.54e-03	71	31	2	C0024713
Disease	Manic	GSK3A GSK3B	3.05e-03	78	31	2	C0338831
Disease	Depression, Bipolar	GSK3A GSK3B	3.13e-03	79	31	2	C0005587

Protein segments in the cluster

Peptide	Gene	Start	Entry
NKKTQPHPLEWNSFT	CPED1	516	A4D0V7
PGPHQTLFSNWKKLK	CYP2J2	241	P51589
FKPHLTFMKLSKSPW	AKAP7	216	Q9P0M2
NFLPHSPSKKDSEWK	AKAP13	1726	Q12802
KSWNQQHFALLFPKP	CYLC2	26	Q14093
EKSPFLSLSPHQQWK	LINC00469	106	Q8N7U9
GKSHQSLFKWKTVPN	RAD51AP2	1041	Q09MP3
FRPLHKPQWFLINKK	RAD17	521	O75943
PPKQSKKNSWNQIHY	PTPN4	466	P29074
FWHRKKISPNKKPFS	MCM3AP	501	O60318
KSWNQKHFALTFPKP	CYLC1	26	P35663
FPSENAAEWKKLFKP	GXYLT1	181	Q4G148
KAVLPKTWPQNFSSH	PLD4	271	Q96BZ4
FPQIKAHPWTKVFKS	GSK3A	356	P49840
PPFSSWKDLQTFKQK	COL28A1	106	Q2UY09
FKFPQIKAHPWTKVF	GSK3B	291	P49841
KFFWLHKPAKVLSPE	A3GALT2	296	U3KPV4
KEQSQSAHLWKSPFP	HOXC13	231	P31276
PYFKHIAKPGWKNSI	FOXM1	271	Q08050
QAYHPIPFSWNKKPK	METTL17	351	Q9H7H0
PTNKFSFDWKLKAHI	TMEM132C	121	Q8N3T6
FFQWIFSKKKSKPAP	SPATA31A6	1166	Q5VVP1
FQWIFSKKKSKPAPV	SPATA31A7	1171	Q8IWB4
KPSKWKFNRTAFLHQ	ST8SIA3	86	O43173
NKAFHIWSKKEKFSP	NCAPD3	686	P42695
KNFLHSKENPKEFFW	C12orf29	91	Q8N999
LKQRFWKHANPAAKP	CLSPN	531	Q9HAW4
FQWIFSKKKSKPAPV	SPATA31A3	1171	Q5VYP0
LHDAFFKWQTKPKLT	SF3B2	571	Q13435
FQWIFSKKKSKPAPV	SPATA31A1	1171	Q5TZJ5
FQWIFSKKKSKPAPV	SPATA31A5	1171	Q5VU36
ETFHPDPNWKNFQKP	TRAF4	406	Q9BUZ4
PLKFIVKKNPHHSQW	XPA	161	P23025
HWKFPQEQNKTKPEF	USP17L7	436	P0C7H9
HWKFPQEQNKTKPEF	USP17L2	436	Q6R6M4
KPWKSQQPKKAFRYH	ZNF439	156	Q8NDP4