Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionABC-type transporter activity

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

5.20e-0849836GO:0140359
GeneOntologyMolecularFunctionATP hydrolysis activity

DMC1 ABCB9 ABCA12 MYO19 IGHMBP2 ATAD2B HELZ2 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

2.72e-074418312GO:0016887
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

DMC1 ABCB9 RASA1 ABCA12 MYO19 IGHMBP2 ATAD2B LRRK2 HELZ2 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

3.45e-067758314GO:0017111
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

6.18e-06109836GO:0042626
GeneOntologyMolecularFunctionATP-dependent activity

DMC1 ABCB9 ABCA12 MYO19 IGHMBP2 ATAD2B HELZ2 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

8.47e-066148312GO:0140657
GeneOntologyMolecularFunctionpyrophosphatase activity

DMC1 ABCB9 RASA1 ABCA12 MYO19 IGHMBP2 ATAD2B LRRK2 HELZ2 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

8.55e-068398314GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

DMC1 ABCB9 RASA1 ABCA12 MYO19 IGHMBP2 ATAD2B LRRK2 HELZ2 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

8.67e-068408314GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

DMC1 ABCB9 RASA1 ABCA12 MYO19 IGHMBP2 ATAD2B LRRK2 HELZ2 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

8.67e-068408314GO:0016818
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

9.86e-05178836GO:0015399
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

NUP133 NUP188 NUP205

1.49e-0425833GO:0017056
GeneOntologyMolecularFunctionheme transmembrane transporter activity

ABCC5 ABCB6

6.03e-049832GO:0015232
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC5 ABCC6

7.52e-0410832GO:0043225
GeneOntologyMolecularFunctionacyltransferase activity

CUL5 MED18 BRCA1 CIITA HECTD4 NCOA1 HERC6 GPAT2 KAT14 FBXL3

1.38e-037758310GO:0016746
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC5 ABCC6

1.73e-0315832GO:0008559
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCC5 ABCB6

1.97e-0316832GO:0015562
GeneOntologyMolecularFunctionoligopeptide transmembrane transporter activity

ABCB9 ABCC5

1.97e-0316832GO:0035673
GeneOntologyCellularComponentnuclear pore inner ring

NUP188 NUP205

4.77e-053842GO:0044611
DomainAAA+_ATPase

DMC1 ABCB9 ABCA12 IGHMBP2 ATAD2B HELZ2 ABCC5 ABCB6 ABCA7 ABCC6

7.22e-101448210IPR003593
DomainAAA

DMC1 ABCB9 ABCA12 IGHMBP2 ATAD2B HELZ2 ABCC5 ABCB6 ABCA7 ABCC6

7.22e-101448210SM00382
DomainABC_transporter_CS

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

2.75e-0842826IPR017871
DomainABC_tran

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

6.30e-0848826PF00005
DomainABC_TRANSPORTER_2

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

6.30e-0848826PS50893
DomainABC_TRANSPORTER_1

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

7.15e-0849826PS00211
DomainABC_transporter-like

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

8.10e-0850826IPR003439
DomainABC_membrane

ABCB9 ABCC5 ABCB6 ABCC6

3.43e-0624824PF00664
DomainABC_TM1F

ABCB9 ABCC5 ABCB6 ABCC6

6.52e-0628824PS50929
DomainABC1_TM_dom

ABCB9 ABCC5 ABCB6 ABCC6

6.52e-0628824IPR011527
DomainARM-type_fold

DNAJC13 NBEAL1 PKP3 TTC12 LRRK2 ZER1 PPP6R1 NUP188 STKLD1

1.76e-05339829IPR016024
DomainP-loop_NTPase

DMC1 ABCB9 CIITA ABCA12 MYO19 IGHMBP2 ATAD2B LRRK2 HELZ2 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

1.76e-058488214IPR027417
Domain-

DMC1 ABCB9 ABCA12 MYO19 IGHMBP2 ATAD2B LRRK2 HELZ2 ABCC5 ABCB6 ABCA7 ABCC6

9.60e-0574682123.40.50.300
DomainARM-like

DNAJC13 PKP3 TTC12 LRRK2 ZER1 STKLD1

1.21e-03270826IPR011989
DomainABC_A

ABCA12 ABCA7

1.22e-0312822IPR026082
Domain-

CIITA NTRK2 LRRK2 ZER1 LRRC4B FBXL3

2.88e-033218263.80.10.10
Domain-

DNAJC13 PKP3 TTC12 LRRK2 ZER1

2.95e-032228251.25.10.10
DomainL_dom-like

CIITA NTRK2 LRRK2 ZER1 LRRC4B FBXL3

3.21e-03328826IPR032675
DomainC2_dom

PREB C2CD3 RASA1 BAIAP3

5.89e-03164824IPR000008
PathwayKEGG_ABC_TRANSPORTERS

ABCB9 ABCA12 ABCC5 ABCB6 ABCA7 ABCC6

2.86e-0844606M11911
PathwayREACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT

ABCB9 ABCA12 ABCC5 ABCB6 PSMD3 ABCA7 ABCC6

1.94e-0799607MM14986
PathwayREACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT

ABCB9 ABCA12 ABCC5 ABCB6 PSMD3 ABCA7 ABCC6

2.54e-07103607M758
PathwayREACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS

ABCA12 NUP133 ABCB6 PSMD3 NUP188 ABCC6 NUP205

9.63e-06177607M27476
PathwayREACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION

NUP133 NUP188 NUP205

1.39e-0424603MM15658
PathwayREACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION

NUP133 NUP188 NUP205

1.99e-0427603M29807
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR10G9 OR10G8 OR10G7 OR10G4

2.20e-0470604MM14984
PathwayREACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS

CUL5 NUP133 PSMD3 NUP188 NUP205

2.33e-04131605M5283
PathwayKEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA

NUP133 NUP188 NUP205

2.74e-0430603M47752
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

BRCA1 NUP133 NUP188 NUP205

3.18e-0477604M27226
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

CUL5 PREB QSOX1 DPH1 MAN1A2 BRCA1 NFE2L2 NUP133 NCOA1 PSMD3 PPP6R1 NUP188 ST8SIA4 FBXL3 TBC1D20 NUP205

3.26e-0414756016M19806
PathwayREACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

NUP133 NUP188 NUP205

3.33e-0432603M29579
PathwayREACTOME_ABC_TRANSPORTER_DISORDERS

ABCA12 ABCB6 PSMD3 ABCC6

3.34e-0478604M27473
PathwayREACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS

NUP133 NUP188 NUP205

3.65e-0433603M27016
PathwayREACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN

NUP133 NUP188 NUP205

3.99e-0434603M27041
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP133 NUP188 NUP205

4.35e-0435603M27320
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

BRCA1 NUP133 NUP188 NUP205

4.44e-0484604MM14929
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP133 NUP188 NUP205

4.74e-0436603M26974
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP133 NUP188 NUP205

4.74e-0436603M27245
PathwayBIOCARTA_BARD1_PATHWAY

FANCD2 BRCA1

4.91e-048602M22050
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

NUP133 NUP188 NUP205

5.14e-0437603M1029
PathwayREACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS

NUP133 NUP188 NUP205

5.14e-0437603M27038
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

PREB QSOX1 DPH1 MAN1A2 BRCA1 NFE2L2 NUP133 NCOA1 PSMD3 PPP6R1 NUP188 ST8SIA4 FBXL3 TBC1D20 NUP205

5.52e-0413896015MM15307
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP133 NUP188 NUP205

6.01e-0439603M27238
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP133 NUP188 NUP205

6.47e-0440603MM14945
PathwayREACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS

NUP133 NUP188 NUP205

6.96e-0441603M29574
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

NUP133 NUP188 NUP205

6.96e-0441603MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP133 NUP188 NUP205

7.48e-0442603MM15039
PathwayREACTOME_SUMOYLATION

BRCA1 NUP133 NCOA1 NUP188 NUP205

7.48e-04169605MM14919
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP133 NUP188 NUP205

8.01e-0443603MM14609
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP133 NUP188 NUP205

8.01e-0443603M26975
PathwayREACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS

NUP133 NUP188 NUP205

8.57e-0444603M109
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP133 NUP188 NUP205

9.77e-0446603M27397
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP133 NUP188 NUP205

1.04e-0347603M27395
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP133 NUP188 NUP205

1.04e-0347603MM14939
PathwayREACTOME_HEME_SIGNALING

NFE2L2 HELZ2 NCOA1

1.18e-0349603M41832
PathwayREACTOME_GENE_SILENCING_BY_RNA

NUP133 NUP188 NUP205

1.18e-0349603MM14837
PathwayREACTOME_SUMOYLATION

BRCA1 NUP133 NCOA1 NUP188 NUP205

1.24e-03189605M27214
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP133 NUP188 NUP205

1.25e-0350603MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP133 NUP188 NUP205

1.32e-0351603MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP133 NUP188 NUP205

1.48e-0353603M27212
PathwayREACTOME_SNRNP_ASSEMBLY

NUP133 NUP188 NUP205

1.56e-0354603M29594
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP133 NUP188 NUP205

1.64e-0355603MM14917
PathwayBIOCARTA_AMAN_PATHWAY

MAN1A2 ST8SIA4

1.81e-0315602M22009
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP133 NUP188 NUP205

1.92e-0358603MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

NUP133 NUP188 NUP205

1.92e-0358603MM14736
PathwayREACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS

BRCA1 NFE2L2 HELZ2 NCOA1 PSMD3

1.96e-03210605M41836
PathwayREACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS

NUP133 NUP188 NUP205

2.01e-0359603M27606
PathwayKEGG_MEDICUS_REFERENCE_HOMOLOGOUS_RECOMBINATION_IN_ICLR

FANCD2 BRCA1

2.06e-0316602M47855
PathwayREACTOME_CYTOPROTECTION_BY_HMOX1

NFE2L2 HELZ2 NCOA1

2.11e-0360603M41830
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCA12 ABCA7

2.33e-0317602MM14552
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

HELZ2 NCOA1

2.61e-0318602MM15034
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

HELZ2 NCOA1

2.61e-0318602M26942
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCA12 ABCA7

2.61e-0318602M524
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP133 NUP188 NUP205

2.65e-0365603MM15147
PathwayBIOCARTA_ATRBRCA_PATHWAY

FANCD2 BRCA1

2.91e-0319602MM1478
PathwayREACTOME_HIV_INFECTION

CUL5 NUP133 PSMD3 NUP188 NUP205

2.97e-03231605M12469
PathwayREACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY

NUP133 NUP188 NUP205

3.02e-0368603MM14921
PathwayREACTOME_COPII_MEDIATED_VESICLE_TRANSPORT

PREB PPP6R1 TBC1D20

3.15e-0369603M27113
PathwayREACTOME_CIRCADIAN_CLOCK

HELZ2 NCOA1 FBXL3

3.28e-0370603M938
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP133 NUP188 NUP205

3.41e-0371603M27394
Pubmed

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.

ABCB9 ABCA12 ABCC5 ABCB6 ABCC6

1.97e-09228558894702
Pubmed

Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene.

BRCA1 NFE2L2

5.90e-06285223353771
Pubmed

Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer.

FANCD2 BRCA1

5.90e-06285217333336
Pubmed

Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways.

CIITA NCOA1

5.90e-06285212933903
Pubmed

Breast cancer susceptibility gene 1 regulates oxidative damage via nuclear factor erythroid 2-related factor 2 in oral cancer cells.

BRCA1 NFE2L2

5.90e-06285235512617
Pubmed

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

FANCD2 BRCA1

5.90e-06285211239454
Pubmed

Alcohol metabolism in human cells causes DNA damage and activates the Fanconi anemia-breast cancer susceptibility (FA-BRCA) DNA damage response network.

FANCD2 BRCA1

5.90e-06285221919919
Pubmed

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

ABCB9 ABCC5 ABCB6 CYP4F2 ABCA7 ABCC6

8.21e-0619385619343046
Pubmed

A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism.

NFE2L2 LRRK2

1.77e-05385237674036
Pubmed

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

FANCD2 BRCA1

1.77e-05385227373334
Pubmed

CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.

BRCA1 NFE2L2

1.77e-05385234103686
Pubmed

Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.

FANCD2 BRCA1

1.77e-05385219671671
Pubmed

Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.

NFE2L2 LRRK2

1.77e-05385228028237
Pubmed

BRCA1-independent ubiquitination of FANCD2.

FANCD2 BRCA1

1.77e-05385212887909
Pubmed

Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences.

NFE2L2 NTRK2

1.77e-05385234238051
Pubmed

Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.

QSOX1 NFE2L2

1.77e-05385233770521
Pubmed

S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.

FANCD2 BRCA1

1.77e-05385212239151
Pubmed

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.

FANCD2 BRCA1

1.77e-05385227264184
Pubmed

Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.

ABCC5 ABCA7 ABCC6

2.41e-052385310708515
Pubmed

RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells.

FANCD2 BRCA1

3.53e-05485226385482
Pubmed

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.

BRCA1 NFE2L2

3.53e-05485224567396
Pubmed

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.

FANCD2 BRCA1

3.53e-05485221203397
Pubmed

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

BRCA1 NFE2L2

3.53e-05485223857982
Pubmed

Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure.

FANCD2 BRCA1

3.53e-05485224708616
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

BRCA1 HECTD4 HELZ2 NUP133 KIF14 NUP205

3.53e-0525085633536335
Pubmed

Probing nuclear pore complex architecture with proximity-dependent biotinylation.

SYNE1 NUP133 NUP188 NUP205

3.92e-057785424927568
Pubmed

Integrated structural analysis of the human nuclear pore complex scaffold.

NUP133 NUP188 NUP205

5.45e-053085324315095
Pubmed

The Structure Inventory of the Nuclear Pore Complex.

NUP133 NUP188 NUP205

5.45e-053085327016207
Pubmed

The proteasome is involved in determining differential utilization of double-strand break repair pathways.

BRCA1 PSMD3

5.87e-05585217563742
Pubmed

Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway.

FANCD2 BRCA1

5.87e-05585225652403
Pubmed

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

FANCD2 BRCA1

5.87e-05585222445484
Pubmed

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.

BRCA1 NFE2L2

5.87e-05585230733286
Pubmed

cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus.

BRCA1 PSMD3

5.87e-0558529838122
Pubmed

Experimental models of amyotrophic lateral sclerosis.

IGHMBP2 VPS54

5.87e-05585210527800
Pubmed

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.

FANCD2 DMC1 BRCA1

7.29e-053385319714462
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

C2CD3 ZNF516 HECTD4 HELZ2 C19orf44 FRMD8 ZER1 PPP6R1 NUP188 FHIP1B ABCA7

7.89e-051105851135748872
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

CUL5 FANCD2 NFE2L2 NUP133 PSMD3 PPP6R1 NUP188 NUP205

7.98e-0557185837167062
Pubmed

Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.

FANCD2 BRCA1

8.80e-05685224966277
Pubmed

Architecture of the linker-scaffold in the nuclear pore.

NUP188 NUP205

8.80e-05685235679425
Pubmed

ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.

FANCD2 ABCB6

8.80e-05685222258451
Pubmed

Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch.

PIEZO2 NTRK2

8.80e-05685237725982
Pubmed

Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

RASA1 CIITA

8.80e-05685222988097
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SYNE1 HELZ2 GRIP2 FHIP1B

1.18e-0410285411214970
Pubmed

Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome.

NUP188 NUP205

1.23e-04785226878725
Pubmed

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

FANCD2 NFE2L2

1.23e-04785224184056
Pubmed

BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells.

BRCA1 NCOA1

1.23e-04785216860316
Pubmed

Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation.

DMC1 BRCA1

1.23e-04785218663141
Pubmed

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.

DMC1 BRCA1

1.23e-04785222549958
Pubmed

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.

BRCA1 NFE2L2

1.23e-04785222331464
Pubmed

Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.

FANCD2 BRCA1

1.23e-04785212913077
Pubmed

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.

NUP133 NUP188 NUP205

1.30e-044085337516964
Pubmed

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.

DMC1 BRCA1

1.64e-04885230393076
Pubmed

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

ABCA12 ABCA7

1.64e-04885224293640
Pubmed

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

ABCC5 ABCC6

1.64e-04885215802388
Pubmed

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons.

PIEZO2 NTRK2

1.64e-04885237028432
Pubmed

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.

DMC1 BRCA1

1.64e-04885232051414
Pubmed

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin.

FANCD2 BRCA1

2.10e-04985232092106
Pubmed

Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.

RASA1 NTRK2

2.10e-0498528530078
Pubmed

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice.

DMC1 BRCA1

2.62e-041085235648791
Pubmed

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

FANCD2 BRCA1

2.62e-041085226658019
Pubmed

MDC1 is a mediator of the mammalian DNA damage checkpoint.

FANCD2 BRCA1

3.20e-041185212607005
Pubmed

HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection.

C2CD3 ST8SIA4

3.83e-041285225011556
Pubmed

Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.

CUL5 PPP6R1

3.83e-041285235512830
Pubmed

The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice.

DMC1 BRCA1

3.83e-041285231453335
Pubmed

Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice.

DMC1 BRCA1

3.83e-041285220551173
Pubmed

Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system.

NTRK2 PKD2L1

3.83e-041285225256039
Pubmed

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

HELZ2 NCOA1

3.83e-041285212189208
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

CUL5 FANCD2 DPH1 ARHGEF28 NCOA1 VPS54 NUP188 HSD11B1L KAT14 TBC1D20 NUP205

3.84e-041327851132694731
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

FANCD2 BRCA1 MAP1A ABCA12 TIGD5 PPP6R1 NUP188 PLEKHN1 ABCA7 KAT14

3.94e-041116851031753913
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

QSOX1 C2CD3 DNAJC13 MAP1A PKP3 HELZ2 KIF14 PSMD3

4.29e-0473285834732716
Pubmed

The role of oxidative stress in Parkinson's disease.

NFE2L2 LRRK2

4.52e-041385224252804
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

CDK18 BRCA1 PKP3 ZNF516 NUP205

4.69e-0426285536880596
Pubmed

LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.

NTRK2 LRRC4B

5.27e-041485219755105
Pubmed

A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

RASA1 NTRK2

5.27e-04148528114702
Pubmed

Deletion of maternal UHRF1 severely reduces mouse oocyte quality and causes developmental defects in preimplantation embryos.

CUL5 BRCA1

5.27e-041485230995416
Pubmed

Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198.

RASA1 PSMD3

5.27e-04148521348494
Pubmed

Defining the membrane proteome of NK cells.

PREB DNAJC13 MAN1A2 IGHMBP2 HELZ2 NUP133 KIF14 PSMD3 NUP188 NUP205

5.61e-041168851019946888
Pubmed

The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.

FANCD2 BRCA1

6.07e-041585219536649
Pubmed

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.

PIEZO2 NTRK2

6.07e-041585237541195
Pubmed

Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions.

DMC1 BRCA1

6.07e-041585238684656
Pubmed

Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.

FANCD2 BRCA1

6.07e-041585227073218
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

MPO FANCD2 ATP6AP2 PKP3 NUP133 PSMD3 PPP6R1 NUP188 NUP205

6.27e-0497485928675297
Pubmed

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

FANCD2 BRCA1

6.93e-041685227760317
Pubmed

Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5.

MPO BRCA1

6.93e-04168529177778
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

C2CD3 BRCA1 ABCB9 SYNE1 ABCC5 PSMD3 OR10G9 OR10G8 OR10G7 NUP205 OR10G4

7.66e-041442851135575683
Pubmed

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.

NUP188 NUP205

7.84e-041785210668806
Pubmed

A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.

MPO BRCA1 NFE2L2

8.38e-047585320644561
Pubmed

Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.

CUL5 ZER1

8.80e-041885218187417
Pubmed

C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.

PIEZO2 NTRK2

9.83e-041985238915692
Pubmed

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.

DMC1 BRCA1

9.83e-041985221478856
Pubmed

Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.

NFE2L2 GPAT2

9.83e-041985217660561
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

CUL5 PREB TMEM62 ARHGEF28 MYO19 PPP6R1 SYDE1

1.08e-0365085738777146
Pubmed

Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain.

PIEZO2 NTRK2

1.09e-032085236334588
Pubmed

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.

LRRC4B SYDE1

1.09e-032085223791195
Pubmed

Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.

SYNE1 PKP3 ZNF516 PSMD3 FHIP1B

1.17e-0332185532098917
Pubmed

ETAA1 acts at stalled replication forks to maintain genome integrity.

FANCD2 BRCA1

1.20e-032185227723720
Pubmed

The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.

RASA1 ST8SIA4

1.20e-032185219578876
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

MAP1A SYNE1

1.32e-032285212812986
Pubmed

Negative modulation of androgen receptor transcriptional activity by Daxx.

BRCA1 NCOA1

1.32e-032285215572661
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

SYNE1 HELZ2 NUP133 NUP188 NUP205

1.35e-0333285525693804
InteractionAHR interactions

FANCD2 BRCA1 NFE2L2 CLEC11A NCOA1 KIF14 PSMD3

1.21e-06132837int:AHR
InteractionTMOD3 interactions

FANCD2 RASA1 MYO19 LRRK2 KIF14 PSMD3 FHIP1B KAT14

7.21e-06243838int:TMOD3
GeneFamilyOlfactory receptors, family 10

OR10G9 OR10G8 OR10G7 OR10G4

7.70e-0566624157
GeneFamilyNucleoporins

NUP133 NUP188 NUP205

1.77e-04326231051
GeneFamilyUPF1 like RNA helicases

IGHMBP2 HELZ2

6.24e-04116221169
GeneFamilyATP binding cassette subfamily B

ABCB9 ABCB6

6.24e-0411622806
GeneFamilyATP binding cassette subfamily C

ABCC5 ABCC6

8.81e-0413622807
GeneFamilyATP binding cassette subfamily A

ABCA12 ABCA7

1.03e-0314622805
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

FANCD2 BRCA1

2.11e-0320622548
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

C2CD3 BAIAP3

6.76e-0336622823
CoexpressionAtlasdev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

FANCD2 DNAJC13 BRCA1 NUP133 KIF14 NUP188 NUP205

4.57e-05258787gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k2_1000
CoexpressionAtlasdev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

FANCD2 DNAJC13 BRCA1 NUP133 KIF14 NUP188 NUP205

5.54e-05266787gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
DrugPF-01378883-00 [351320-41-7]; Down 200; 10uM; MCF7; HT_HG-U133A

THPO ARHGEF28 CIITA NTRK2 KLK12 ZER1 NUP188

8.03e-061988376363_DN
DrugEsculetin [305-01-1]; Down 200; 22.4uM; MCF7; HT_HG-U133A

BRCA1 ABCB9 MAP1A CLEC11A PKP3 TTC12 SYDE1

8.30e-061998376499_DN
Drugdocetaxel

ABCA12 KIF14 ABCC5 ABCB6 ABCA7 ABCC6

9.26e-06133836ctd:C067311
Drugharmol sulfate

ABCC5 ST8SIA4 ABCC6

1.30e-0513833CID005488302
DiseaseKeratosis Blennorrhagica

MPO NFE2L2

7.59e-055822C0022594
DiseaseKeratosis

MPO NFE2L2

7.59e-055822C0022593
DiseaseKeratoma

MPO NFE2L2

7.59e-055822C0086501
Diseaseobsolete_red blood cell distribution width

DNAJC13 MYO19 ATAD2B ZNF516 HECTD4 HELZ2 ABCC5 PKD2L1 ABCB6 TIGD5 STKLD1 HSD11B1L ABCA7

8.36e-0513478213EFO_0005192
Diseasemonocyte percentage of leukocytes

MPO BRCA1 CIITA TTC39C ZNF516 NCOA1 ABCC5 PSMD3 GPAT2

1.96e-04731829EFO_0007989
DiseaseAlzheimer disease

MPO ABCA7

2.11e-048822cv:C0002395
DiseaseFanconi anemia (is_implicated_in)

FANCD2 BRCA1

3.38e-0410822DOID:13636 (is_implicated_in)
Diseaseneutrophil count, basophil count

MPO HECTD4 NCOA1 PSMD3 ABCA7

4.09e-04224825EFO_0004833, EFO_0005090
DiseasePancreatic Ductal Adenocarcinoma

ABCA12 SYDE1

4.13e-0411822C1335302
DiseaseChromosome Breaks

BRCA1 NFE2L2

6.79e-0414822C0333704
DiseaseChromosome Breakage

BRCA1 NFE2L2

6.79e-0414822C0376628
DiseaseColorectal Neoplasms

ABCA12 SYNE1 ABCC5 ABCB6 ABCC6

1.06e-03277825C0009404
Diseasemyeloid white cell count

MPO DNAJC13 ATAD2B ZNF516 HECTD4 ABCC5 PSMD3 ST8SIA4 ABCA7

1.17e-03937829EFO_0007988
Diseaseneutrophil count

MPO DNAJC13 BRCA1 TTC39C ZNF516 HECTD4 NCOA1 ABCC5 PSMD3 ABCA7 TENT5B

1.51e-0313828211EFO_0004833
Diseaseneutrophil-to-lymphocyte ratio

MPO ATAD2B C19orf44 PSMD3

1.79e-03185824EFO_0008447
DiseaseFanconi Anemia

FANCD2 BRCA1

2.20e-0325822C0015625
Diseasebasophil count

MPO ATAD2B HELZ2 C19orf44 PKD2L1 PSMD3

2.29e-03483826EFO_0005090
DiseaseAcute monocytic leukemia

FANCD2 BRCA1

2.37e-0326822C0023465
Diseasemyeloperoxidase measurement

MPO NUP133

2.37e-0326822EFO_0005243
Diseasechronic obstructive pulmonary disease (biomarker_via_orthology)

MPO NFE2L2

2.75e-0328822DOID:3083 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
LERLLHSTHIRVLAF

TMEM62

331

Q0P6H9
LHLLHALSLVTDVSR

LINC00158

11

P58513
IDRDSTLRRLHHIQI

BRINP3

186

Q76B58
AHLTRRLILDISADS

CUL5

456

Q93034
HLLLLSHLLRLEHSA

BAIAP3

406

O94812
TLLRDRPLLLSHSHS

CIITA

596

P33076
NIVTLHDLIHTDRSL

CDK18

201

Q07002
TARTIILSTHHLDEA

ABCA12

1526

Q86UK0
TSRRVELLIFSHLHE

ABCB6

341

Q9NP58
RLGSHLVLTAHTEAL

HSD11B1L

51

Q7Z5J1
HILAHASTTRISLRK

DMC1

291

Q14565
DIRIDTTHLLDSLRL

DPH1

156

Q9BZG8
REGRTLILSTHHLDE

ABCA7

986

Q8IZY2
IRIIETLDLHSSLHQ

NBEAL1

491

Q6ZS30
HSRTDLSRDLAALHE

RASA1

986

P20936
LRERLIDALESHHDT

QSOX1

146

O00391
HETRIHILNLLITSL

NUP205

981

Q92621
SLEVSSHRESLLHLA

ARHGEF28

156

Q8N1W1
LRFLLLHRHDTHTIL

FHIP1B

371

Q8N612
HHSRLSDLVNTAILI

NUP133

656

Q8WUM0
HDHRITSRINLIDLA

KIF14

591

Q15058
LLILLVIRVDSHLHT

OR10G7

41

Q8NGN6
LLILLVIRVDSHLHT

OR10G4

41

Q8NGN3
VRHLDRIDSVLLTHI

MAP1A

76

P78559
SLVHRLFTILHLEES

MCUB

166

Q9NWR8
ASTSHEHDLRLLRLR

KLK12

101

Q9UKR0
ILLERHRLIHVTSSA

MYO19

951

Q96H55
SLSAHELHRAVREVL

FRMD8

51

Q9BZ67
ALLHTLERFSVHRLD

ATAD2B

786

Q9ULI0
HTLLLREHNRLATEL

MPO

416

P05164
HSSRLEAHLTRDELR

NFE2L2

446

Q16236
HLSSLISRHDDEATR

KAT14

6

Q9H8E8
GERHSLLLLTNHRVL

HERC6

31

Q8IVU3
LTRTLQHRIALHVAD

LRRK2

1966

Q5S007
LLILLVIRVDSHLHT

OR10G8

41

Q8NGN5
SDHIRLSDLIAARIL

DPY19L2

451

Q6NUT2
LVFHLLAELLRTVHT

HECTD4

2751

Q9Y4D8
SVLDHSLESLIHRLR

MED18

26

Q9BUE0
DRILVAHDIHTKTRL

PTER

291

Q96BW5
ILLAILRIHSASGRH

OR9G4

236

Q8NGQ1
HLRLQRTLHSIDLEI

ABCC5

571

O15440
ELQVLHDISSLLSRH

ATP6AP2

186

O75787
LRRKSSTRHIHALEL

BRCA1

611

P38398
ALRVHVVLSSLSSHL

C2CD3

1551

Q4AC94
LLTLRHLHSVLEELR

C20orf202

56

A1L168
LLALSSEKHVRLEHL

FBXL3

241

Q9UKT7
QASRHLHASLLRSLD

C19orf44

606

Q9H6X5
LRSLLQHSLSLLRAH

GPAT2

501

Q6NUI2
LELSALVSKRHHEIL

CYP4F2

226

P78329
DLLTLAHLHVSRATV

DNAJC13

941

O75165
HHRATLRLSEKFILL

MAN1A2

26

O60476
LHHLSRLRDLVDDTN

LAS2

351

Q8IYD9
VARARAAEHTLLHRL

HELZ2

706

Q9BYK8
GIHLTRLRHDEIITL

GRIP2

101

Q9C0E4
SLLETFQLDTRLLHH

FANCD2

1326

Q9BXW9
IRTDTFKHLRHLEIL

LRRC4B

101

Q9NT99
LLILLVIRVDSHLHT

OR10G9

41

Q8NGN4
DHTFHLELEAARLLR

SYDE1

316

Q6ZW31
LSKLHETLRTHTRLV

ERVW-1

151

Q9UQF0
HLDLTQLHRLSLESS

PLEKHN1

426

Q494U1
HTRALHRLIAKSREL

SYNE1

2786

Q8NF91
AHVGLHTLRSRISII

ABCC6

1331

O95255
SSLTERHKILHRLLQ

NCOA1

681

Q15788
VLDRRRTLNISHDLH

ST8SIA4

111

Q92187
EALEHLRHRVIATRS

TENT5B

256

Q96A09
VFSHLDRSLLEDIRH

ABCB9

26

Q9NP78
HVRLHALDTRVVELT

CLEC11A

126

Q9Y240
SRKHFRHLDLSELIL

NTRK2

131

Q16620
LDRVRTADHHQLRSL

PKP3

661

Q9Y446
RLSASLLHSHDTETR

PREB

56

Q9HCU5
SNRLSILDRLLHTHP

RIN2

81

Q8WYP3
REESLLSHIERDHIT

ZNF516

211

Q92618
HKLRHLDISRDRLSS

ZER1

246

Q7Z7L7
LHARLRTATLRHDAD

PSMD3

231

O43242
LEHILEHLNSSLESR

STKLD1

461

Q8NE28
LTAHSSVARHLLRDL

IGHMBP2

461

P38935
SRTIFHDITRLHLDD

PIEZO2

1091

Q9H5I5
HFTEATLHLLLTLAR

NUP188

1331

Q5SRE5
ILELHIHRLRYLSSI

PKD2L1

371

Q9P0L9
DLHTSSHLDTLLERE

PPP6R1

6

Q9UPN7
VIHHDRARLLAALLS

TTC12

336

Q9H892
LATSLVEKLSTHHLR

TBC1D20

161

Q96BZ9
LHVRIHAALASLREL

TTC39C

566

Q8N584
HSRVLSDLTHLAALA

TIGD5

506

Q53EQ6
ESSYHLLISRLDLHI

UHRF1BP1

321

Q6BDS2
RTLLHTHDKSRTDLE

VPS54

146

Q9P1Q0
RVLSKLLRDSHVLHS

THPO

31

P40225