Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-leucine binding	UBR2 GLUD2	1.79e-04	7	59	2	GO:0070728
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR6F1 TAS2R16 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34 TAS2R30 GRM8	2.40e-04	884	59	10	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	2.69e-04	431	59	7	GO:0004984
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR6F1 TAS2R16 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34 TAS2R30 GRM8	5.36e-06	582	59	10	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR6F1 TAS2R16 ABCA4 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34 TAS2R30 GRM8	5.42e-06	722	59	11	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR6F1 TAS2R16 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34 TAS2R30	9.03e-06	485	59	9	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR6F1 TAS2R16 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34 TAS2R30	1.67e-05	524	59	9	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR6F1 TAS2R16 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34 TAS2R30	2.34e-05	547	59	9	GO:0007606
Domain	ARM-type_fold	AP4E1 MTOR TNPO2 DOCK9 ARMC10 FRYL ATXN10 GPRASP2	1.22e-05	339	60	8	IPR016024
Domain	ARM-like	AP4E1 MTOR TNPO2 ARMC10 FRYL ATXN10 GPRASP2	2.45e-05	270	60	7	IPR011989
Domain	-	AP4E1 MTOR TNPO2 ARMC10 FRYL ATXN10	7.73e-05	222	60	6	1.25.10.10
Domain	Olfact_rcpt	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	2.56e-04	393	60	7	IPR000725
Domain	zf-C2H2_6	ZNF684 ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	5.03e-04	314	60	6	PF13912
Domain	ARM-rpt_dom	ARMC10 GPRASP2	5.48e-04	11	60	2	IPR006911
Domain	Arm_2	ARMC10 GPRASP2	5.48e-04	11	60	2	PF04826
Domain	zf-H2C2_2	ZNF286B ZNF286A	9.01e-04	14	60	2	PF13465
Domain	KRAB	ZNF684 ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	9.96e-04	358	60	6	PS50805
Domain	KRAB	ZNF684 ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	9.96e-04	358	60	6	PF01352
Domain	KRAB	ZNF684 ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	1.16e-03	369	60	6	SM00349
Domain	KRAB	ZNF684 ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	1.18e-03	370	60	6	IPR001909
Domain	-	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	1.41e-03	679	60	8	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	1.62e-03	694	60	8	IPR013087
Domain	TAS2R	TAS2R16 TAS2R30	3.14e-03	26	60	2	PF05296
Domain	T2R	TAS2R16 TAS2R30	3.14e-03	26	60	2	IPR007960
Domain	ZINC_FINGER_C2H2_2	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	3.21e-03	775	60	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	3.27e-03	777	60	8	PS00028
Domain	Znf_C2H2-like	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	3.78e-03	796	60	8	IPR015880
Domain	Znf_C2H2	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	4.05e-03	805	60	8	IPR007087
Domain	ZnF_C2H2	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	4.14e-03	808	60	8	SM00355
Domain	GPCR_Rhodpsn_7TM	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	5.50e-03	670	60	7	IPR017452
Domain	7tm_1	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	5.81e-03	677	60	7	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	6.19e-03	685	60	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	6.49e-03	691	60	7	PS50262
Domain	GPCR_Rhodpsn	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	6.54e-03	692	60	7	IPR000276
Domain	zf-C2H2	ZNF684 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	6.59e-03	693	60	7	PF00096
Domain	DEAH_ATP_HELICASE	EP400 YTHDC2	6.62e-03	38	60	2	PS00690
Domain	-	HCN3 GGCX	1.04e-02	48	60	2	2.60.120.10
Pathway	REACTOME_SENSORY_PERCEPTION	OR6F1 TAS2R16 ABCA4 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34 TAS2R30	3.04e-05	636	46	10	M41834
Pathway	REACTOME_SENSORY_PERCEPTION	OR6F1 TAS2R16 ABCA4 OR1E1 OR1E2 TAS2R30	3.31e-05	190	46	6	MM15687
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R16 TAS2R30 GRM8	2.34e-04	37	46	3	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R16 TAS2R30 GRM8	2.74e-04	39	46	3	M793
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	AP4E1 TRAF6 ABCA4 APPL2 MTOR FRYL ATXN10 MED23 GRM8 JMJD1C ABTB2 ZNF879	1.17e-06	1242	60	12	30973865
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TRAF6 APPL2 MYCBP2 TNPO2 DNER RANBP9 FIBP ASTN2 ATXN10 TUBGCP5 GPRASP2 ZNF879	1.67e-06	1285	60	12	35914814
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR6F1 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	2.19e-06	219	60	6	12213199
Pubmed	Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis.	MTOR JMJD1C	2.93e-06	2	60	2	32034158
Pubmed	Cutting edge: requirement for TRAF6 in the induction of T cell anergy.	TRAF6 CD28	2.93e-06	2	60	2	18097000
Pubmed	RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors.	RANBP9 GRM8	2.93e-06	2	60	2	18555800
Pubmed	The Ran-binding protein RanBPM can depress the NF-κB pathway by interacting with TRAF6.	TRAF6 RANBP9	2.93e-06	2	60	2	21805090
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	MYCBP2 MTOR TNPO2 RANBP9 YTHDC2 ATP13A3 GPRASP2 GGCX AAR2	5.55e-06	754	60	9	33060197
Pubmed	Systematic and quantitative assessment of the ubiquitin-modified proteome.	UBR2 MYCBP2 RANBP9 TUBGCP5 AAR2	8.11e-06	158	60	5	21906983
Pubmed	RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI.	TRAF6 RANBP9	8.77e-06	3	60	2	24103590
Pubmed	Ran binding protein 9 (RanBPM) binds IFN-λR1 in the IFN-λ signaling pathway.	TRAF6 RANBP9	8.77e-06	3	60	2	28547582
Pubmed	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.	UBR2 MYCBP2 RANBP9 TUBGCP5 AAR2	9.15e-06	162	60	5	21890473
Pubmed	The TSC-mTOR signaling pathway regulates the innate inflammatory response.	MTOR CD28	1.75e-05	4	60	2	18848473
Pubmed	Odorant receptors govern the formation of a precise topographic map.	OR1E1 OR1E2	1.75e-05	4	60	2	9546391
Pubmed	Allelic inactivation regulates olfactory receptor gene expression.	OR1E1 OR1E2	2.92e-05	5	60	2	8087849
Pubmed	mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer.	MTOR DNER	2.92e-05	5	60	2	36883564
Pubmed	A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.	GLI3 PMEL	2.92e-05	5	60	2	18397875
Pubmed	K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.	TRAF6 MTOR	2.92e-05	5	60	2	23911927
Pubmed	The human olfactory receptor gene family.	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2 OR2T2 OR2T34	4.01e-05	541	60	7	14983052
Pubmed	CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1.	MTOR CD28	4.37e-05	6	60	2	18337562
Pubmed	Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.	TRAF6 MTOR	4.37e-05	6	60	2	26279575
Pubmed	mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.	TRAF6 MTOR	8.14e-05	8	60	2	23524951
Pubmed	Mouse-human orthology relationships in an olfactory receptor gene cluster.	OR1E1 OR1E2	8.14e-05	8	60	2	11170746
Pubmed	Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences.	OR1E1 OR1E2	8.14e-05	8	60	2	16902085
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	VPS13D MYCBP2 MTOR GLUD2 TUBGCP5 GGCX AAR2	8.18e-05	606	60	7	36538041
Pubmed	Sensitivity-dependent hierarchical receptor codes for odors.	OR1E1 OR1E2	1.05e-04	9	60	2	12588732
Pubmed	The chromosomal distribution of mouse odorant receptor genes.	OR1E1 OR1E2 PMEL	1.14e-04	54	60	3	8570653
Pubmed	Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.	OR1E1 OR1E2	1.59e-04	11	60	2	26361056
Pubmed	Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.	OR1E1 OR1E2	1.59e-04	11	60	2	8004088
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	MYCBP2 MTOR ATP13A3 GGCX AAR2	1.66e-04	298	60	5	32353859
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R16 TAS2R30	1.91e-04	12	60	2	12379855
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	VPS13D ZNF286B ASTN2 TUBGCP5 JMJD1C ZNF286A	2.06e-04	493	60	6	15368895
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	UBR2 MYCBP2 RANBP9 TUBGCP5 AAR2	2.08e-04	313	60	5	16196087
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR1E1 OR1E2	2.26e-04	13	60	2	11014824
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	MYCBP2 TNPO2 ATXN10	2.26e-04	68	60	3	25754235
Pubmed	GLI3 repressor controls functional development of the mouse ureter.	GLI3 HCN3	2.63e-04	14	60	2	21339645
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR1E1 OR1E2	2.63e-04	14	60	2	7528109
Pubmed	Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.	UBR2 MYCBP2 RANBP9 AAR2	2.70e-04	180	60	4	21139048
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR2T35 OR1E1 OR1E2	2.90e-04	74	60	3	15081110
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MYCBP2 MTOR	3.03e-04	15	60	2	31285543
Pubmed	Quantitative trait loci for steady-state platelet count in mice.	OR1E1 OR1E2	3.03e-04	15	60	2	15520881
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2	3.05e-04	340	60	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2	3.05e-04	340	60	5	11802173
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	UBR2 MYCBP2 TNPO2 RANBP9 FIBP ATXN10	3.13e-04	533	60	6	25544563
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2	3.17e-04	343	60	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR6F1 OR2T35 OR1E1 OR1E2 OR2AG2	3.30e-04	346	60	5	14611657
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	TRAF6 MYCBP2 TNPO2 RANBP9 ELOVL1 FIBP FRYL ATXN10 JMJD1C	3.36e-04	1284	60	9	17353931
Pubmed	Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.	OR1E1 OR1E2	3.46e-04	16	60	2	10673334
Pubmed	Olfactory receptors and signalling elements in the Grueneberg ganglion.	OR1E1 OR1E2	3.91e-04	17	60	2	16805845
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TNPO2 RANBP9 ATXN10 IDH3B MED23 AAR2	4.07e-04	560	60	6	35241646
Pubmed	A novel family of mammalian taste receptors.	TAS2R16 TAS2R30	6.02e-04	21	60	2	10761934
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR2 TRAF6 MYCBP2	6.04e-04	95	60	3	29643511
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	EP400 GLI3 RANBP9 FIBP YTHDC2 IDH3B TUBGCP5 GGCX	6.39e-04	1116	60	8	31753913
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R16 TAS2R30	6.61e-04	22	60	2	12734386
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FSIP2 VPS13D MYCBP2 MTOR ZNF286B FRYL ABTB2	6.87e-04	861	60	7	36931259
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR1E1 OR1E2	7.23e-04	23	60	2	10706615
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R16 TAS2R30	7.23e-04	23	60	2	20022913
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	TRAF6 FRYL MED23	7.64e-04	103	60	3	29539633
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR1E1 OR1E2	7.88e-04	24	60	2	9119360
Pubmed	Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.	UBR2 RANBP9 AAR2	8.07e-04	105	60	3	22505724
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	MYCBP2 YTHDC2 IDH3B JMJD1C	8.21e-04	242	60	4	34011540
Pubmed	Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.	TRAF6 CD28	8.56e-04	25	60	2	19898481
Pubmed	Receptors for bitter and sweet taste.	TAS2R16 TAS2R30	8.56e-04	25	60	2	12139982
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R16 TAS2R30	9.26e-04	26	60	2	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R16 TAS2R30	9.99e-04	27	60	2	12581520
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	MTOR ATXN10	9.99e-04	27	60	2	23027611
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	TRAF6 MYCBP2	1.07e-03	28	60	2	35474067
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R16 TAS2R30	1.07e-03	28	60	2	15744053
Pubmed	Distribution of olfactory receptor genes in the human genome.	OR1E1 OR1E2	1.07e-03	28	60	2	9500546
Pubmed	SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.	MTOR ATXN10	1.07e-03	28	60	2	32801337
Pubmed	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	ARHGAP24 TNPO2 HCN3 ARMC10 ATXN10	1.11e-03	453	60	5	27113764
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	AP4E1 GLI3 YTHDC2 JMJD1C	1.12e-03	263	60	4	34702444
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	UBR2 APPL2 TUBGCP5	1.13e-03	118	60	3	24453475
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	EP400 MTOR IDH3B	1.19e-03	120	60	3	27320910
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R16 TAS2R30	1.23e-03	30	60	2	12679530
Pubmed	Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.	UBR2 MYCBP2 AAR2	1.31e-03	124	60	3	23000965
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	RANBP9 FRYL MED23	1.46e-03	129	60	3	23022380
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	PALD1 UBR2 TRAF6 YTHDC2	1.46e-03	283	60	4	21903422
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	VPS13D EP400 MED23	1.49e-03	130	60	3	12421765
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R16 TAS2R30	1.58e-03	34	60	2	15496549
Pubmed	Global identification of modular cullin-RING ligase substrates.	UBR2 TUBGCP5 AAR2	1.63e-03	134	60	3	21963094
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	EP400 MED23 JMJD1C	1.63e-03	134	60	3	25452129
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	APPL2 MYCBP2 DOCK9 ATXN10 JMJD1C	1.67e-03	497	60	5	23414517
Cytoband	1q44	OR6F1 OR2T35 OR2T2 OR2T34	1.37e-05	110	60	4	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR6F1 OR2T35 OR2T2 OR2T34	2.49e-05	128	60	4	chr1q44
Cytoband	19p13.2	TNPO2 ZNF709 ZNF443 ZNF440	2.36e-04	229	60	4	19p13.2
Cytoband	1p34.2	ZNF684 ELOVL1	2.56e-03	57	60	2	1p34.2
GeneFamily	Olfactory receptors, family 2	OR2T35 OR2AG2 OR2T2 OR2T34	1.23e-04	113	41	4	149
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF684 GLI3 ZNF286B ZNF709 ZNF443 ZNF879 ZNF440 ZNF286A	1.78e-04	718	41	8	28
GeneFamily	Taste 2 receptors	TAS2R16 TAS2R30	3.53e-03	39	41	2	1162
GeneFamily	Olfactory receptors, family 1	OR1E1 OR1E2	3.71e-03	40	41	2	147
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC10 GPRASP2	4.27e-03	43	41	2	409
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP24 APPL2 DOCK9	1.13e-02	206	41	3	682
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ABCA4 DNER PAQR5 ASTN2	1.20e-06	138	60	5	a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ABCA4 GLI3 DNER ASTN2	5.33e-06	187	60	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD28 FRYL TAS2R30 MED23 TUBGCP5	6.87e-06	197	60	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
Disease	hippocampal CA3 volume	CFAP47 GLI3 ASTN2	4.19e-05	36	55	3	EFO_0009395
Disease	APOE carrier status, cerebral amyloid angiopathy	AP4E1 DNER YTHDC2	6.68e-05	42	55	3	EFO_0006790, EFO_0007659
Disease	cortical surface area measurement	PALD1 KIF6 MYCBP2 CD28 GLI3 DOCK9 ASTN2 FRYL ATXN10 MED23	1.68e-04	1345	55	10	EFO_0010736
Disease	cortical thickness	PALD1 KIF6 VPS13D ABCA4 MYCBP2 GLI3 DOCK9 ASTN2 JMJD1C	1.99e-04	1113	55	9	EFO_0004840
Disease	Tinnitus, wellbeing measurement	ASTN2 GRM8 AAR2	7.74e-04	96	55	3	EFO_0007869, HP_0000360
Disease	migraine disorder, glucose measurement	KIF6 JMJD1C	1.53e-03	31	55	2	EFO_0004468, MONDO_0005277

Protein segments in the cluster

Peptide	Gene	Start	Entry
MCMNTSIHAHTYART	nan	1	Q6ZS92
RHLREMFTHMNSLSE	ZNF286A	171	Q9HBT8
THTQLYTSHFDLMKM	EP400	2456	Q96L91
SKRSRLLHSDYMNMT	CD28	181	P10747
KYRSGRTIIMSTHHM	ABCA4	1106	P78363
QYVMLHDMVATHSTV	ATP13A3	256	Q9H7F0
YSSMILFTSLNHERM	ATXN10	176	Q9UBB4
AAMMKHHTLYINLIS	AAR2	286	Q9Y312
MEVSASMLFRVQHHY	ASTN2	1226	O75129
MTVTNDHQHMLHSYI	ARMC10	206	Q8N2F6
FISYHMMDTHSAQLE	AP4E1	1006	Q9UPM8
QTMIQKMVSSYLVHH	RANBP9	366	Q96S59
SHFHMDTLLMTTHNL	CYP2F1	281	P24903
DTVSETMTPMHYHLR	PALD1	731	Q9ULE6
ATSYHQKHMIMTLLA	PAQR5	216	Q9NXK6
LASLIAIGHTMYTMH	OR2AG2	151	A6NM03
HMDSRLHTPMYFLLS	OR2T2	51	Q6IF00
IHMEYLHAMDSTRFS	GLI3	266	P10071
LTTIHMHSHSTYMQA	HSFY1	296	Q96LI6
THHDLFTRTMIVMND	JMJD1C	211	Q15652
ATLHSMMVRSSHQLS	KIAA1109	2906	Q2LD37
ASTMYTTMLSHSHLE	FSIP2	4781	Q5CZC0
LVNLAHMMSLYSTHT	FRYL	2141	O94915
LHTLLEMFSYRMHHI	MED23	601	Q9ULK4
HRSHIPYRNSMMTSV	KIF6	291	Q6ZMV9
MHFVNSLHNYIMTRI	TUBGCP5	891	Q96RT8
LRSSYHTAEQDMMVS	OR2T34	266	Q8NGX1
HMDSRLHTPMYFLLS	OR2T35	51	Q8NGX2
RQYSHALFKAMSHML	HCN3	296	Q9P1Z3
TMMQRTHSQEYAHSI	GRM8	26	O00222
MTANHESYLLMASTQ	ARHGAP24	96	Q8N264
NMLRHLNLEYHSSMI	IDH3B	331	O43837
ASYHHAVETVVNMLM	DOCK9	991	Q9BZ29
IHNIFRMTESHLMVT	APPL2	526	Q8NEU8
FHAMINSSVHVIMYL	ELOVL1	166	Q9BW60
HMAESLTNMPRHSLY	DNER	626	Q8NFT8
AMLQSAMTRTHNHRS	CFAP47	561	Q6ZTR5
AYTMERSARQIMHTA	GLUD2	511	P49448
TTFHAMLHTLLMARL	OR1E2	161	P47887
LMLVSTSHQLHTPMY	OR6F1	46	Q8NGZ6
LTTFHAMLHTLLMAR	OR1E1	151	P30953
MRIFRDQSLSHHHTM	MTOR	956	P42345
VLQSDTMDHYRTFHM	FIBP	51	O43427
TMDHYRTFHMLERLL	FIBP	56	O43427
YAFILMHSTSLMLSS	TAS2R16	266	Q9NYV7
IKLRSAMYHSNMTLT	TAS2R30	166	P59541
QRHHTARTEMEMYAI	SAMD7	91	Q7Z3H4
RMLRHLTMTIDYHTL	GPRASP2	701	Q96D09
HTFHRLLQTISDLMM	MYCBP2	3651	O75592
RAMLGTHTMEVTVYH	PMEL	176	P40967
SELSDLVSRAMHHMQ	ABTB2	341	Q8N961
FISHSSVRRHMVMHS	ZNF440	181	Q8IYI8
LTMERIHHYNMSTSL	ZNF684	111	Q5T5D7
MMVHSRSHQHVKITY	GGCX	401	P38435
TQSHMRMLAQAVHSL	TRAF6	266	Q9Y4K3
HMHSIIQYMLQRTQD	TNPO2	251	O14787
YMCHSSLNRHMRSHT	ZNF709	111	Q8N972
DSTHRYQVFMLHSNM	YTHDC2	651	Q9H6S0
FRQSSSLMTHMRIHT	ZNF879	521	B4DU55
ALSHRSSFRSHMIMH	ZNF443	401	Q9Y2A4
ERHLREMFTHMNSLS	ZNF286B	171	P0CG31
ARSVYHQLFMSSLLM	UBR2	366	Q8IWV8
MARSMESRSHHYVLE	VPS13D	226	Q5THJ4