Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	MAP kinase activity	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	9.70e-14	16	76	7	GO:0004707
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	MAPK14 MAPK12 STK17B PRKAG1 DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	9.47e-07	446	76	11	GO:0004674
GeneOntologyMolecularFunction	protein serine kinase activity	MAPK14 MAPK12 STK17B DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.15e-06	363	76	10	GO:0106310
GeneOntologyMolecularFunction	protein kinase activity	MAPK14 MAPK12 STK17B PRKAG1 PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	2.60e-06	600	76	12	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	MAPK14 MAPK12 STK17B PRKAG1 PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.41e-05	709	76	12	GO:0016773
GeneOntologyMolecularFunction	kinase activity	MAPK14 MAPK12 STK17B PRKAG1 PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	2.95e-05	764	76	12	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	MAPK14 MAPK12 STK17B PRKAG1 PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 TERT MAP3K2	4.87e-05	938	76	13	GO:0016772
GeneOntologyMolecularFunction	dynein intermediate chain binding	DYNLL2 DYNLT2 DYNLL1	3.75e-04	37	76	3	GO:0045505
GeneOntologyBiologicalProcess	ERBB2-ERBB3 signaling pathway	MAPK1 MAPK3 SOS1	1.39e-05	13	77	3	GO:0038133
GeneOntologyBiologicalProcess	ERBB3 signaling pathway	MAPK1 MAPK3 SOS1	1.77e-05	14	77	3	GO:0038129
GeneOntologyBiologicalProcess	stress-activated MAPK cascade	MAPK14 MAPK1 MAPK3 MAPK11	7.97e-05	61	77	4	GO:0051403
GeneOntologyBiologicalProcess	regulation of Golgi inheritance	MAPK1 MAPK3	8.21e-05	4	77	2	GO:0090170
GeneOntologyBiologicalProcess	stress-activated protein kinase signaling cascade	MAPK14 MAPK1 MAPK3 MAPK11	1.29e-04	69	77	4	GO:0031098
GeneOntologyBiologicalProcess	developmental growth	SLC39A12 MAPK14 ALMS1 ASPM PKDCC BBS4 FLRT3 MAPK1 MAPK11 UNC79 LEPR SOS1	1.33e-04	911	77	12	GO:0048589
GeneOntologyBiologicalProcess	ERBB2 signaling pathway	MAPK1 MAPK3 SOS1	1.37e-04	27	77	3	GO:0038128
GeneOntologyBiologicalProcess	telomere maintenance via telomerase	SMG5 MAPK1 MAPK3 TERT	1.98e-04	77	77	4	GO:0007004
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	SMG5 MAPK1 MAPK3 TERT	2.64e-04	83	77	4	GO:0006278
GeneOntologyBiologicalProcess	trachea formation	MAPK1 MAPK3	2.85e-04	7	77	2	GO:0060440
GeneOntologyBiologicalProcess	positive regulation of macrophage proliferation	MAPK1 MAPK3	2.85e-04	7	77	2	GO:0120041
GeneOntologyBiologicalProcess	positive regulation of cilium assembly	TAPT1 BBS4 DYNLL1	3.00e-04	35	77	3	GO:0045724
GeneOntologyBiologicalProcess	telomere maintenance via telomere lengthening	SMG5 MAPK1 MAPK3 TERT	3.60e-04	90	77	4	GO:0010833
GeneOntologyBiologicalProcess	regulation of pro-B cell differentiation	SOS1 SOS2	3.80e-04	8	77	2	GO:2000973
GeneOntologyBiologicalProcess	regulation of macrophage proliferation	MAPK1 MAPK3	3.80e-04	8	77	2	GO:0120040
GeneOntologyCellularComponent	cytoplasmic dynein complex	DYNLL2 DYNLT2 DYNLL1	8.85e-05	24	76	3	GO:0005868
Domain	MAP_kinase_CS	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	7.07e-10	12	75	5	IPR003527
Domain	MAPK	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	7.07e-10	12	75	5	PS01351
Domain	MAPK_p38	MAPK14 MAPK12 MAPK11	2.48e-07	4	75	3	IPR008352
Domain	Pkinase	MAPK14 MAPK12 STK17B PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	3.35e-07	381	75	11	PF00069
Domain	Kinase-like_dom	MAPK14 MAPK12 STK17B PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2 SOS1	1.56e-06	542	75	12	IPR011009
Domain	Ser/Thr_kinase_AS	MAPK14 MAPK12 STK17B DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.58e-06	357	75	10	IPR008271
Domain	S_TKc	MAPK14 MAPK12 STK17B DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.66e-06	359	75	10	SM00220
Domain	PROTEIN_KINASE_ST	MAPK14 MAPK12 STK17B DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.79e-06	362	75	10	PS00108
Domain	PROTEIN_KINASE_ATP	MAPK14 MAPK12 STK17B PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	2.08e-06	459	75	11	PS00107
Domain	Protein_kinase_ATP_BS	MAPK14 MAPK12 STK17B DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	2.70e-06	379	75	10	IPR017441
Domain	Prot_kinase_dom	MAPK14 MAPK12 STK17B PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	3.83e-06	489	75	11	IPR000719
Domain	PROTEIN_KINASE_DOM	MAPK14 MAPK12 STK17B PKDCC DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	4.13e-06	493	75	11	PS50011
Domain	MAPK_ERK1/2	MAPK1 MAPK3	1.59e-05	2	75	2	IPR008349
Domain	Dynein_light_1/2_CS	DYNLL2 DYNLL1	1.59e-05	2	75	2	IPR019763
Domain	MAPK_ERK3/4	MAPK4 MAPK6	4.76e-05	3	75	2	IPR008350
Domain	Dynein_light	DYNLL2 DYNLL1	4.76e-05	3	75	2	PF01221
Domain	DYNEIN_LIGHT_1	DYNLL2 DYNLL1	4.76e-05	3	75	2	PS01239
Domain	Dynein_light	DYNLL2 DYNLL1	4.76e-05	3	75	2	SM01375
Domain	Dynein_light_chain_typ-1/2	DYNLL2 DYNLL1	4.76e-05	3	75	2	IPR001372
Domain	-	DYNLL2 DYNLL1	4.76e-05	3	75	2	3.30.740.10
Domain	GPR107-like	GPR108 GPR107	9.50e-05	4	75	2	IPR009637
Domain	Lung_7-TM_R	GPR108 GPR107	9.50e-05	4	75	2	PF06814
Domain	PKD_channel	PKD2L2 MCOLN1	8.55e-04	11	75	2	PF08016
Domain	PKD1_2_channel	PKD2L2 MCOLN1	8.55e-04	11	75	2	IPR013122
Domain	FERM-adjacent	FRMD5 FRMD3	1.21e-03	13	75	2	IPR014847
Domain	FA	FRMD5 FRMD3	1.21e-03	13	75	2	SM01195
Domain	FA	FRMD5 FRMD3	1.21e-03	13	75	2	PF08736
Domain	IMPORTIN_B_NT	TNPO1 IPO13	1.40e-03	14	75	2	PS50166
Domain	Ras_G-nucl-exch_fac_CS	SOS1 SOS2	1.40e-03	14	75	2	IPR019804
Domain	IBN_N	TNPO1 IPO13	1.62e-03	15	75	2	PF03810
Domain	IBN_N	TNPO1 IPO13	1.84e-03	16	75	2	SM00913
Domain	Importin-beta_N	TNPO1 IPO13	2.08e-03	17	75	2	IPR001494
Domain	RUN	PLEKHM2 DENND5A	2.34e-03	18	75	2	SM00593
Domain	ARM-type_fold	TNPO1 ASPM IPO13 NBEA UNC79 RYR3	2.41e-03	339	75	6	IPR016024
Domain	RUN	PLEKHM2 DENND5A	2.60e-03	19	75	2	PS50826
Domain	RUN	PLEKHM2 DENND5A	2.60e-03	19	75	2	PF02759
Domain	Run_dom	PLEKHM2 DENND5A	2.60e-03	19	75	2	IPR004012
Domain	Myosin-like_IQ_dom	ASPM MYO5C	2.60e-03	19	75	2	IPR027401
Domain	-	ASPM MYO5C	2.60e-03	19	75	2	4.10.270.10
Domain	-	TAF6L SOS1 SOS2	2.69e-03	69	75	3	1.10.20.10
Domain	RasGEFN	SOS1 SOS2	2.88e-03	20	75	2	SM00229
Domain	RasGEF_N	SOS1 SOS2	3.18e-03	21	75	2	PF00618
Domain	Ez/rad/moesin-like	FRMD5 FRMD3	3.18e-03	21	75	2	IPR000798
Domain	Ras-like_Gua-exchang_fac_N	SOS1 SOS2	3.49e-03	22	75	2	IPR000651
Domain	RASGEF_NTER	SOS1 SOS2	3.49e-03	22	75	2	PS50212
Domain	FERM_CS	FRMD5 FRMD3	4.15e-03	24	75	2	IPR019747
Domain	Histone-fold	TAF6L SOS1 SOS2	4.54e-03	83	75	3	IPR009072
Domain	FERM_C	FRMD5 FRMD3	4.86e-03	26	75	2	PF09380
Domain	RASGEF	SOS1 SOS2	4.86e-03	26	75	2	PS00720
Domain	FERM_C	FRMD5 FRMD3	5.23e-03	27	75	2	SM01196
Domain	FERM_PH-like_C	FRMD5 FRMD3	5.23e-03	27	75	2	IPR018980
Domain	DEATH	THOC1 DAPK1	5.23e-03	27	75	2	SM00005
Domain	RASGEF_CAT	SOS1 SOS2	6.02e-03	29	75	2	PS50009
Domain	Ubiquitin-rel_dom	SACS UBQLN3 FRMD5 FRMD3	6.43e-03	184	75	4	IPR029071
Domain	RasGEF	SOS1 SOS2	6.44e-03	30	75	2	PF00617
Domain	-	SOS1 SOS2	6.44e-03	30	75	2	1.10.840.10
Domain	Ras_GEF_dom	SOS1 SOS2	6.44e-03	30	75	2	IPR023578
Domain	RASGEF_cat_dom	SOS1 SOS2	6.44e-03	30	75	2	IPR001895
Domain	RasGEF	SOS1 SOS2	6.44e-03	30	75	2	SM00147
Domain	PH_dom-like	PLEKHM2 NBEA FRMD5 FRMD3 SOS1 SOS2	7.28e-03	426	75	6	IPR011993
Domain	FERM_N	FRMD5 FRMD3	7.75e-03	33	75	2	PF09379
Domain	Death	THOC1 DAPK1	7.75e-03	33	75	2	PF00531
Domain	FERM_N	FRMD5 FRMD3	7.75e-03	33	75	2	IPR018979
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	MAPK14 MAPK12 PRKAG1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2 SOS1 SOS2	6.08e-12	132	59	11	M39338
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPF_TO_TLR2_4_MAPK_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	6.46e-12	6	59	5	M47766
Pathway	WP_MAPK_CASCADE	MAPK14 MAPK12 MAPK1 MAPK3 MAP3K2 SOS1 SOS2	6.11e-11	33	59	7	M39594
Pathway	WP_INSULIN_SIGNALING	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2 SOS1 SOS2	1.04e-09	160	59	10	MM15956
Pathway	WP_INSULIN_SIGNALING	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2 SOS1 SOS2	1.04e-09	160	59	10	M39482
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.46e-09	81	59	8	M13863
Pathway	REACTOME_SIGNALLING_TO_ERKS	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1	5.08e-09	34	59	6	M13881
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 MAP3K2 SOS1 SOS2	8.60e-09	101	59	8	M1979
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK6 MAPK11 MAP3K2	2.72e-08	76	59	7	MM1433
Pathway	WP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	3.27e-08	78	59	7	M39824
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1 SOS2	3.57e-08	79	59	7	M11816
Pathway	PID_LYMPH_ANGIOGENESIS_PATHWAY	MAPK14 MAPK1 MAPK3 MAPK11 SOS1	5.38e-08	25	59	5	M274
Pathway	WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION	MAPK12 MAPK1 MAPK3 MAPK4 MAPK6	5.38e-08	25	59	5	M39384
Pathway	REACTOME_ACTIVATION_OF_PPARGC1A_PGC_1ALPHA_BY_PHOSPHORYLATION	MAPK14 MAPK12 PRKAG1 MAPK11	5.70e-08	10	59	4	M27146
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK14 MAPK1 MAPK3 MAPK11	5.70e-08	10	59	4	MM15135
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK14 MAPK1 MAPK3 MAPK11	5.70e-08	10	59	4	M13962
Pathway	KEGG_MEDICUS_REFERENCE_TLR2_4_MAPK_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	6.64e-08	26	59	5	M47565
Pathway	REACTOME_SIGNALLING_TO_ERKS	MAPK14 MAPK1 MAPK3 MAPK11 SOS1	6.64e-08	26	59	5	MM14716
Pathway	WP_FGFR3_SIGNALING_IN_CHONDROCYTE_PROLIFERATION_AND_TERMINAL_DIFFERENTIATION	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	8.13e-08	27	59	5	M39838
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	MAPK14 MAPK12 MAPK1 MAPK11 SOS1	9.86e-08	28	59	5	M39572
Pathway	WP_MAPK_CASCADE	MAPK14 MAPK12 MAPK1 MAPK3 MAP3K2	9.86e-08	28	59	5	MM15976
Pathway	WP_CANNABINOID_RECEPTOR_SIGNALING	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	1.19e-07	29	59	5	M39676
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	2.68e-07	14	59	4	M47364
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	2.68e-07	14	59	4	M47365
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	2.68e-07	14	59	4	M47366
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	2.68e-07	14	59	4	M47378
Pathway	KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	2.68e-07	14	59	4	M47488
Pathway	SIG_CD40PATHWAYMAP	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	2.74e-07	34	59	5	M12705
Pathway	KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1 SOS2	3.13e-07	108	59	7	M9904
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47367
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47375
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47592
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47593
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47640
Pathway	KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47485
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47473
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47474
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47480
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47495
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47496
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47497
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47472
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47535
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	3.65e-07	15	59	4	M47531
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	3.69e-07	36	59	5	M39908
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1	3.71e-07	68	59	6	M39456
Pathway	REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE	TNPO1 MAPK14 MAPK12 ALMS1 DYNLL2 PRKAG1 BBS4 DYNLT2 DYNLL1 MAPK11	3.74e-07	297	59	10	M27050
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	4.85e-07	16	59	4	M47363
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	4.85e-07	16	59	4	M47373
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	4.85e-07	16	59	4	M47381
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	4.85e-07	16	59	4	M47804
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	4.85e-07	16	59	4	M47483
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	5.73e-07	118	59	7	M39852
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	6.32e-07	17	59	4	M47376
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1 SOS2	8.94e-07	126	59	7	M16763
Pathway	REACTOME_ERK_MAPK_TARGETS	MAPK14 MAPK1 MAPK3 MAPK11	1.02e-06	19	59	4	MM14780
Pathway	REACTOME_SIGNALLING_TO_RAS	MAPK14 MAPK12 MAPK11 SOS1	1.28e-06	20	59	4	M12256
Pathway	BIOCARTA_CREB_PATHWAY	MAPK14 MAPK1 MAPK3 SOS1	1.28e-06	20	59	4	MM1520
Pathway	BIOCARTA_CREB_PATHWAY	MAPK14 MAPK1 MAPK3 SOS1	1.91e-06	22	59	4	M9070
Pathway	REACTOME_ERK_MAPK_TARGETS	MAPK14 MAPK1 MAPK3 MAPK11	1.91e-06	22	59	4	M13408
Pathway	WP_SIGNAL_TRANSDUCTION_OF_S1P_RECEPTOR	MAPK12 MAPK1 MAPK3 MAPK6	2.31e-06	23	59	4	MM15952
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	MAPK14 MAPK1 MAPK3 MAPK11	2.76e-06	24	59	4	M27553
Pathway	KEGG_DORSO_VENTRAL_AXIS_FORMATION	MAPK1 MAPK3 SOS1 SOS2	2.76e-06	24	59	4	M11190
Pathway	WP_IL4_SIGNALING	MAPK14 MAPK1 MAPK3 MAPK11 SOS1	2.92e-06	54	59	5	M39720
Pathway	WP_HEPATITIS_B_INFECTION	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1 SOS2	3.01e-06	151	59	7	M39801
Pathway	PID_IL2_1PATHWAY	MAPK14 MAPK1 MAPK3 MAPK11 SOS1	3.20e-06	55	59	5	M122
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	MAPK14 MAPK1 MAPK3 MAPK11	3.28e-06	25	59	4	MM15269
Pathway	BIOCARTA_PYK2_PATHWAY	MAPK14 MAPK1 MAPK3 SOS1	3.86e-06	26	59	4	MM1431
Pathway	WP_MAPK_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 SOS2	4.42e-06	160	59	7	MM15990
Pathway	BIOCARTA_PYK2_PATHWAY	MAPK14 MAPK1 MAPK3 SOS1	4.52e-06	27	59	4	M7739
Pathway	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	MAPK1 MAPK3 SOS1 SOS2	4.52e-06	27	59	4	M1718
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	MAPK14 MAPK1 MAPK3 MAPK11	4.52e-06	27	59	4	MM14779
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1 SOS2	4.61e-06	161	59	7	M39770
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	MAPK14 MAPK1 MAPK3 MAPK11	5.26e-06	28	59	4	MM15132
Pathway	WP_THERMOGENESIS	MAPK14 MAPK12 PRKAG1 MAPK11 SOS1 SOS2	5.70e-06	108	59	6	M39746
Pathway	KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	5.82e-06	62	59	5	M15569
Pathway	BIOCARTA_BIOPEPTIDES_PATHWAY	MAPK14 MAPK1 MAPK3 SOS1	6.08e-06	29	59	4	MM1356
Pathway	BIOCARTA_BIOPEPTIDES_PATHWAY	MAPK14 MAPK1 MAPK3 SOS1	6.08e-06	29	59	4	M13494
Pathway	REACTOME_SIGNALING_BY_NTRK1_TRKA	MAPK14 MAPK1 MAPK3 MAPK11 SOS1	6.31e-06	63	59	5	MM14714
Pathway	WP_MAPK_SIGNALING	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 MAP3K2 SOS1 SOS2	7.89e-06	246	59	8	M39597
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	MAPK14 MAPK1 MAPK3 MAPK11	8.00e-06	31	59	4	M15195
Pathway	REACTOME_SIGNAL_ATTENUATION	MAPK1 MAPK3 SOS1	8.18e-06	10	59	3	M14236
Pathway	REACTOME_SIGNAL_ATTENUATION	MAPK1 MAPK3 SOS1	8.18e-06	10	59	3	MM15440
Pathway	REACTOME_APOPTOSIS	PSMA2 DYNLL2 DAPK1 PSMD3 DYNLL1 MAPK1 MAPK3	9.25e-06	179	59	7	M15303
Pathway	PID_VEGFR1_2_PATHWAY	MAPK14 PRKAG1 MAPK1 MAPK3 MAPK11	9.89e-06	69	59	5	M237
Pathway	WP_ALPHA_6_BETA_4_SIGNALING	MAPK14 MAPK1 MAPK3 SOS1	1.03e-05	33	59	4	M39503
Pathway	PID_MAPK_TRK_PATHWAY	MAPK14 MAPK1 MAPK3 MAP3K2	1.17e-05	34	59	4	M270
Pathway	KEGG_LEISHMANIA_INFECTION	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	1.22e-05	72	59	5	M3126
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY	MAPK1 MAPK3 SOS1 SOS2	1.32e-05	35	59	4	M47379
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 MAP3K2 SOS1 SOS2	1.43e-05	267	59	8	M10792
Pathway	WP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	1.49e-05	75	59	5	M39568
Pathway	REACTOME_SIGNALING_BY_NTRKS	MAPK14 MAPK1 MAPK3 MAPK11 SOS1	1.49e-05	75	59	5	MM14652
Pathway	REACTOME_SIGNALLING_TO_RAS	MAPK14 MAPK11 SOS1	1.49e-05	12	59	3	MM14657
Pathway	WP_LEPTIN_SIGNALING	MAPK14 MAPK1 MAPK3 LEPR SOS1	1.59e-05	76	59	5	M39491
Pathway	KEGG_VEGF_SIGNALING_PATHWAY	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	1.59e-05	76	59	5	M1749
Pathway	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE	MAPK14 MAPK1 MAPK3 MAPK11	1.65e-05	37	59	4	MM14899
Pathway	WP_MFAP5MEDIATED_OVARIAN_CANCER_CELL_MOTILITY_AND_INVASIVENESS	MAPK1 MAPK3 RYR3	1.93e-05	13	59	3	M39463
Pathway	REACTOME_P38MAPK_EVENTS	MAPK14 MAPK12 MAPK11	1.93e-05	13	59	3	M1441
Pathway	REACTOME_SIGNALING_BY_NTRKS	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 SOS1	1.97e-05	134	59	6	M3574
Pubmed	gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	6.68e-16	14	77	7	12239168
Pubmed	The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	5.92e-11	13	77	5	17906618
Pubmed	Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice.	MAPK14 MAPK1 MAPK3 LEPR	1.11e-10	5	77	4	24486509
Pubmed	RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	7.04e-10	20	77	5	32662771
Pubmed	Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.	MAPK1 MAPK3 SOS1 SOS2	7.73e-10	7	77	4	15173068
Pubmed	F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2.	MAPK14 MAPK1 MAPK6 MAPK11	1.54e-09	8	77	4	34703820
Pubmed	Nerve growth factor signaling, neuroprotection, and neural repair.	MAPK14 MAPK12 MAPK1 MAPK3 SOS1	2.96e-09	26	77	5	11520933
Pubmed	MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo.	MAPK14 MAPK12 MAPK1 MAPK3	4.62e-09	10	77	4	12223406
Pubmed	Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.	MAPK14 MAPK1 MAPK3 MAPK6	4.62e-09	10	77	4	8444355
Pubmed	The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 Pathways and the Interaction with Cell-Surface-HSP70.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	28608568
Pubmed	ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	20155832
Pubmed	Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	25118288
Pubmed	Heterogeneous expression of four MAP kinase isoforms in human tissues.	MAPK1 MAPK3 MAPK4	1.04e-08	3	77	3	1319925
Pubmed	Hydrostatic pressures promote initial osteodifferentiation with ERK1/2 not p38 MAPK signaling involved.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	19259952
Pubmed	TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.	MAPK14 MAPK12 MAPK11	1.04e-08	3	77	3	22522454
Pubmed	Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	25592043
Pubmed	Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	22579611
Pubmed	Leishmania initially activates but subsequently down-regulates intracellular mitogen-activated protein kinases and nuclear factor-kappaB signaling in macrophages.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	18406464
Pubmed	Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	18563362
Pubmed	Expression of extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinase in the invasive trophoblasts at the human placental bed.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	18358530
Pubmed	Acute cutaneous barrier disruption activates epidermal p44/42 and p38 mitogen-activated protein kinases in human and hairless guinea pig skin.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	14714552
Pubmed	Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	21448845
Pubmed	Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2- and P38 MAPK-dependent pathways.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	19543489
Pubmed	Genomic loci of human mitogen-activated protein kinases.	MAPK1 MAPK3 MAPK4	1.04e-08	3	77	3	8290275
Pubmed	Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	21085672
Pubmed	Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	17268885
Pubmed	Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	34709510
Pubmed	Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	18372245
Pubmed	ERK1/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 5'-triphosphate-mediated terminal erythroid differentiation of K562 cells.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	17543571
Pubmed	Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	17303382
Pubmed	An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	23332156
Pubmed	Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	24608673
Pubmed	p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	12663671
Pubmed	Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation.	MAPK14 MAPK12 MAPK11	1.04e-08	3	77	3	18256287
Pubmed	Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	20738258
Pubmed	The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells.	MAPK14 MAPK1 MAPK3	1.04e-08	3	77	3	24619413
Pubmed	MAP4K4 is involved in the neuronal development of retinal photoreceptors.	MAPK14 MAPK1 MAPK3 MAPK4	1.08e-08	12	77	4	37290629
Pubmed	Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.	MAPK14 MAPK1 MAPK3 MAPK11	2.19e-08	14	77	4	9687510
Pubmed	PRAK, a novel protein kinase regulated by the p38 MAP kinase.	MAPK14 MAPK12 MAPK1 MAPK11	2.98e-08	15	77	4	9628874
Pubmed	Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice.	MAPK14 MAPK1 LEPR	4.17e-08	4	77	3	22933112
Pubmed	Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	22158075
Pubmed	Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation.	MAPK14 MAPK12 MAPK11	4.17e-08	4	77	3	20610565
Pubmed	Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis.	MAPK14 MAPK12 MAPK11	4.17e-08	4	77	3	18177852
Pubmed	Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	17463321
Pubmed	Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	14634061
Pubmed	Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	15107845
Pubmed	Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo.	MAPK12 MAPK1 MAPK6	4.17e-08	4	77	3	11741894
Pubmed	Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	27878722
Pubmed	LCPTP-MAP kinase interaction: permanent partners or transient associates?	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	12413699
Pubmed	Basic fibroblast growth factor antagonizes activin A-mediated growth inhibition and hemoglobin synthesis in K562 cells by activating ERK1/2 and deactivating p38 MAP kinase.	MAPK1 MAPK3 MAPK11	4.17e-08	4	77	3	15249224
Pubmed	Immune profiling of human prostate epithelial cells determined by expression of p38/TRAF-6/ERK MAP kinases pathways.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	29475459
Pubmed	Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	19418584
Pubmed	Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	15537893
Pubmed	p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.	MAPK14 MAPK12 MAPK11	4.17e-08	4	77	3	19936205
Pubmed	Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	16814421
Pubmed	Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.	MAPK14 MAPK12 MAPK11	4.17e-08	4	77	3	10066767
Pubmed	Essential role for ERK2 mitogen-activated protein kinase in placental development.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	14622137
Pubmed	IL-17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPKα/p38MAPK/ERK1/2 signal pathway in mice.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	30562644
Pubmed	MECP2 promotes cell proliferation by activating ERK1/2 and inhibiting p38 activity in human hepatocellular carcinoma HEPG2 cells.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	24199952
Pubmed	Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	22593579
Pubmed	Expressions and Regulatory Effects of P38/ERK/JNK Mapks in the Adipogenic Trans-Differentiation of C2C12 Myoblasts.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	29268268
Pubmed	Fractalkine increases mesangial cell proliferation through reactive oxygen species and mitogen-activated protein kinases.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	22564616
Pubmed	Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	18434625
Pubmed	Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	12200131
Pubmed	Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	19661066
Pubmed	Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase.	MAPK12 MAPK1 MAPK3	4.17e-08	4	77	3	9564043
Pubmed	Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	10206983
Pubmed	The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	28420753
Pubmed	Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	21908610
Pubmed	Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guérin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	21199725
Pubmed	HB-EGF synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP and involves both p38 and ERK1/2 signaling pathways.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	21413023
Pubmed	Connexin 43 promotes ossification of the posterior longitudinal ligament through activation of the ERK1/2 and p38 MAPK pathways.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	26334722
Pubmed	Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	19676104
Pubmed	Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.	MAPK14 SOS1 SOS2	4.17e-08	4	77	3	31337738
Pubmed	Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.	MAPK14 MAPK1 MAPK3	4.17e-08	4	77	3	19723095
Pubmed	Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.	DAPK1 MAPK1 MAPK3	4.17e-08	4	77	3	15616583
Pubmed	Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.	MAPK14 MAPK1 MAPK3 MAPK4	6.64e-08	18	77	4	21675959
Pubmed	Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.	MAPK14 MAPK1 MAPK3 SOS1	8.39e-08	19	77	4	21041952
Pubmed	Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	22053946
Pubmed	Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	26782637
Pubmed	Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	18703508
Pubmed	Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	10415025
Pubmed	Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	19122200
Pubmed	Arachidonic acid release by H2O2 mediated proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	19199341
Pubmed	Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	18487214
Pubmed	Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	19801662
Pubmed	IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	28938400
Pubmed	Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	9211903
Pubmed	Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	20729213
Pubmed	Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	23088735
Pubmed	p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	17464174
Pubmed	MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.	MAPK1 MAPK3 SOS1	1.04e-07	5	77	3	7478566
Pubmed	Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.	MAPK14 MAPK12 MAPK11	1.04e-07	5	77	3	15632108
Pubmed	Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	18080100
Pubmed	IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	17921324
Pubmed	Sam68 and ERKs regulate leptin-induced expression of OB-Rb mRNA in C2C12 myotubes.	MAPK1 MAPK3 LEPR	1.04e-07	5	77	3	19524014
Pubmed	An optimized immunohistochemical method for detection of phosphorylated mitogen-activated protein kinases.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	18061203
Pubmed	p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.	MAPK12 MAPK1 MAPK3	1.04e-07	5	77	3	22733747
Pubmed	CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	18087676
Pubmed	Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.	MAPK14 MAPK1 MAPK3	1.04e-07	5	77	3	18949384
Interaction	MAPKAPK5 interactions	MAPK14 MAPK12 MAPK1 MAPK4 MAPK6 MAPK11	1.65e-07	66	75	6	int:MAPKAPK5
Interaction	RPS6KA5 interactions	THOC1 MAPK14 DYNLL1 MAPK1 MAPK3 MAPK4 MAPK11	1.09e-06	144	75	7	int:RPS6KA5
Interaction	STAB2 interactions	MAPK14 MAPK1 MAPK3	4.09e-06	9	75	3	int:STAB2
Interaction	DUSP2 interactions	MAPK14 PRKAG1 MAPK1 MAPK4 MAPK11	1.28e-05	81	75	5	int:DUSP2
Interaction	BCL2L11 interactions	SLC39A12 DYNLL2 DYNLL1 MAPK1 MAPK3	1.72e-05	86	75	5	int:BCL2L11
Interaction	PTPN5 interactions	MAPK14 HACD3 MAPK1 MAPK3 MAPK11	1.82e-05	87	75	5	int:PTPN5
Interaction	DUSP16 interactions	MAPK14 ALMS1 ATG2B DHX35 SMG5 MAPK1 MAPK11	2.86e-05	237	75	7	int:DUSP16
Interaction	RPS6KA4 interactions	MAPK14 MAPK1 MAPK3 MAPK4 MAPK11	3.57e-05	100	75	5	int:RPS6KA4
Interaction	MKNK2 interactions	MAPK14 MAPK1 MAPK3 MAPK11	5.23e-05	55	75	4	int:MKNK2
Interaction	SPANXN4 interactions	MAPK14 MAPK12 MAPK1 MAPK3	5.23e-05	55	75	4	int:SPANXN4
Interaction	CLIC5 interactions	MAPK1 MAPK3 MYO5C	7.25e-05	22	75	3	int:CLIC5
Interaction	DUSP4 interactions	MAPK14 PSMA2 PSMD3 MAPK1 MAPK3	7.87e-05	118	75	5	int:DUSP4
Interaction	C4orf36 interactions	MAPK1 MAPK3	8.16e-05	4	75	2	int:C4orf36
Interaction	PTPN7 interactions	MAPK14 MAPK1 MAPK3 MAPK11	1.01e-04	65	75	4	int:PTPN7
Interaction	MBP interactions	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	1.07e-04	126	75	5	int:MBP
Interaction	DPPA3 interactions	TNPO1 ALMS1 DYNLL2 DYNLL1	1.14e-04	67	75	4	int:DPPA3
Interaction	TACSTD2 interactions	TNPO1 SACS STK17B IPO13 VARS2	1.20e-04	129	75	5	int:TACSTD2
Interaction	MKNK1 interactions	MAPK14 MAPK1 MAPK3 MAPK11	1.35e-04	70	75	4	int:MKNK1
Interaction	DUSP10 interactions	MAPK14 MAPK1 MAPK3 MAPK11	1.42e-04	71	75	4	int:DUSP10
Interaction	MAPKAPK2 interactions	MAPK14 MAPK1 MAPK3 MAPK6 MAPK11	1.43e-04	134	75	5	int:MAPKAPK2
Interaction	EML4 interactions	TNPO1 DYNLL2 DYNLL1 MAPK1 MAPK3	1.59e-04	137	75	5	int:EML4
Interaction	ETV1 interactions	MAPK14 MAPK3 TERT	1.69e-04	29	75	3	int:ETV1
Interaction	ANKRD20A4P interactions	DYNLL2 DYNLL1	2.03e-04	6	75	2	int:ANKRD20A4P
Interaction	MAP2K4 interactions	MAPK14 MAPK12 MAPK1 MAP3K2	2.37e-04	81	75	4	int:MAP2K4
Interaction	FAM83D interactions	DYNLL2 DYNLL1 MAPK1 MAPK3	2.48e-04	82	75	4	int:FAM83D
Interaction	ANKRD20A2P interactions	DYNLL2 DYNLL1	2.84e-04	7	75	2	int:ANKRD20A2P
Interaction	REDIC1 interactions	DYNLL2 DYNLL1	2.84e-04	7	75	2	int:REDIC1
Interaction	CDC25C interactions	MAPK14 DZIP3 RER1 MAPK1 MAPK3	2.91e-04	156	75	5	int:CDC25C
Interaction	MAPK12 interactions	MAPK14 MAPK12 MAPK1 MAPK11	2.98e-04	86	75	4	int:MAPK12
Interaction	SUPT20H interactions	TAF6L MAPK14 TAF5L MAPK1	3.12e-04	87	75	4	int:SUPT20H
Interaction	GMFB interactions	MAPK14 MAPK1 MAPK3	3.24e-04	36	75	3	int:GMFB
Interaction	MAP2K3 interactions	MAPK14 MAPK12 MAPK1 MAPK3 TERT MAP3K2	3.45e-04	251	75	6	int:MAP2K3
Interaction	PIPSL interactions	ALMS1 COA1 ASPM SMARCA1 DHX35 MYO5C	3.53e-04	252	75	6	int:PIPSL
Interaction	BCL2 interactions	MAPK14 DYNLL1 MAPK1 MAPK3 MAPK11	3.56e-04	163	75	5	int:BCL2
Interaction	DCTN2 interactions	KBTBD4 ALMS1 PSMA2 DYNLL2 DYNLL1 MAPK6 MYO5C	3.58e-04	356	75	7	int:DCTN2
Interaction	ELK4 interactions	MAPK14 MAPK1 MAPK3 MAPK11	3.86e-04	92	75	4	int:ELK4
Cytoband	15q21	MAPK6 MYO5C	1.51e-04	11	77	2	15q21
GeneFamily	Mitogen-activated protein kinases	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	5.89e-15	13	61	7	651
GeneFamily	Ankyrin repeat domain containing\|Death associated protein kinases	STK17B DAPK1	1.11e-04	5	61	2	1021
GeneFamily	7TM orphan receptors	GPR108 GPR107	1.67e-04	6	61	2	310
GeneFamily	Dyneins, cytoplasmic	DYNLL2 DYNLL1	8.53e-04	13	61	2	538
GeneFamily	Armadillo repeat containing\|Importins	TNPO1 IPO13	1.65e-03	18	61	2	596
GeneFamily	Transient receptor potential cation channels	PKD2L2 MCOLN1	4.00e-03	28	61	2	249
GeneFamily	Proteasome	PSMA2 PSMD3	9.25e-03	43	61	2	690
GeneFamily	WD repeat domain containing	CDC20B NBEA TAF5L WDR17	1.18e-02	262	61	4	362
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMD5 FRMD3	1.24e-02	50	61	2	1293
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA12 SMIM10 ASPM DYNLT2 STAB1	1.03e-05	166	77	5	43f84d3cd58e93ce00c241656c4cba27604b4932
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-NK_T_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAPK12 STK17B CDC20B DZIP3 MAPK1	1.36e-05	176	77	5	dbc4f64cd39b229f2355ca1d0215cc7f6a767dce
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALMS1 CYP27A1 DZIP3 MCOLN1 STAB1	1.48e-05	179	77	5	2c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALMS1 CYP27A1 DZIP3 MCOLN1 STAB1	1.48e-05	179	77	5	6eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	MAPK12 SMIM10 MAPK11 LEPR STAB1	1.97e-05	190	77	5	ac2eb1e51459d187095152e0cd41ae54c1025c6f
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	MAPK12 SMIM10 MAPK11 LEPR STAB1	1.97e-05	190	77	5	6010f16378f2d9cde37c7e7db6a7d9666edaddcc
Drug	SB202474	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.29e-14	14	77	7	CID000005162
Drug	oridonin	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 TERT	1.08e-11	54	77	8	CID000034378
Drug	procymidone	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	6.52e-11	40	77	7	CID000036242
Drug	piribedil	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	9.39e-11	42	77	7	CID000004850
Drug	celiprolol	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	2.16e-10	47	77	7	CID000002663
Drug	DENSPM	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	2.52e-10	48	77	7	CID000004282
Drug	trapidil	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	8.84e-10	57	77	7	CID000005531
Drug	AC1L1CFC	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.00e-09	58	77	7	CID000001874
Drug	CEP-1347	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.13e-09	59	77	7	CID000133005
Drug	dipropionamide	MAPK1 MAPK3 MAPK4 MAPK6	1.80e-09	6	77	4	CID000138646
Drug	dimethyl selenone	MAPK1 MAPK3 MAPK4 MAPK6	1.80e-09	6	77	4	CID000176413
Drug	lysosphingomyelin	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3 STAB1	3.58e-09	160	77	9	CID000005263
Drug	SR144528	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	3.87e-09	70	77	7	CID003081355
Drug	Wkymvm	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	4.28e-09	71	77	7	CID000457933
Drug	potassium phosphate	MAPK14 MAPK12 TACR3 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	7.80e-09	121	77	8	CID000024450
Drug	thunberginol B	MAPK1 MAPK3 MAPK4 MAPK6	8.38e-09	8	77	4	CID005473310
Drug	Clorocruoro Hem	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	8.88e-09	123	77	8	CID003518809
Drug	p38 MAP kinase inhibitor	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.37e-08	130	77	8	CID000004665
Drug	ebselen	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	1.46e-08	131	77	8	CID000003194
Drug	lapatinib	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.66e-08	86	77	7	CID000208908
Drug	arsenate	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	1.85e-08	135	77	8	CID000000233
Drug	ethyl acetate	SLC8A2 MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	2.08e-08	137	77	8	CID000008857
Drug	alpha-ketoisovalerate	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	2.11e-08	89	77	7	CID000000049
Drug	C070379	MAPK14 MAPK12 STK17B MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	2.40e-08	199	77	9	CID003034747
Drug	AC1NOLIT	MAPK14 MAPK12 MAPK3 MAPK11	2.50e-08	10	77	4	CID005090286
Drug	0-to	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 TERT	2.60e-08	141	77	8	CID000002051
Drug	Ro 31	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 SOS1	2.60e-08	141	77	8	CID000214797
Drug	DEAC	MAPK14 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	3.12e-08	55	77	6	CID000007277
Drug	Dethiocoenzyme A	MAPK14 MAPK12 CYP27A1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	3.60e-08	147	77	8	CID000003002
Drug	nemorosone	MAPK14 MAPK12 MAPK3 MAPK11	3.92e-08	11	77	4	CID000637105
Drug	CdCl2	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	4.14e-08	98	77	7	CID000024947
Drug	L001226	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	5.17e-08	30	77	5	CID004373102
Drug	K-Cl	MAPK14 MAPK12 DYNLL2 TACR3 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 TERT RYR3 MYO5C SOS2	5.28e-08	567	77	13	CID000004873
Drug	BAPTA-AM	MAPK14 MAPK12 HACD3 STK17B MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	5.48e-08	293	77	10	CID000002293
Drug	MDL-28842	MAPK14 MAPK1 MAPK3 MAPK11	5.86e-08	12	77	4	CID006441200
Drug	AICAR monophosphate	MAPK14 MAPK12 PRKAG1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	8.04e-08	163	77	8	CID000000200
Drug	N-(4-aminobutyl)-1-naphthalenesulfonamide	MAPK1 MAPK3 MAPK4 MAPK6	8.45e-08	13	77	4	CID000005679
Drug	LBH589	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	8.66e-08	109	77	7	CID006918837
Drug	ERK inhibitor	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 SOS1	9.25e-08	166	77	8	CID001249835
Drug	1pzj	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 SOS1	9.69e-08	167	77	8	CID000447976
Drug	9,12,15-octadecatrienoic acid	MAPK14 MAPK12 PSMD3 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	9.69e-08	167	77	8	CID000000860
Drug	AC1NDP1U	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.25e-07	115	77	7	CID004629339
Drug	hydroxybutyrate	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.25e-07	115	77	7	CID000010413
Drug	pyridinyl imidazole	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	1.35e-07	36	77	5	CID000005171
Drug	BAPTA	MAPK14 MAPK12 SACS DYNLL2 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	1.40e-07	324	77	10	CID000104751
Drug	Ac2-26	MAPK14 MAPK12 MAPK11	1.48e-07	4	77	3	CID000568638
Drug	bovine serum albumin-corticosterone conjugate	MAPK14 MAPK1 MAPK3	1.48e-07	4	77	3	ctd:C439264
Drug	corticosterone-21-hemisuccinate	MAPK14 MAPK1 MAPK3	1.48e-07	4	77	3	ctd:C067957
Drug	NSC-68458	MAPK14 MAPK12 MAPK11	1.48e-07	4	77	3	CID000249771
Drug	MMP-2 Inhibitor I	MAPK14 MAPK12 MAPK3 MAPK11	1.60e-07	15	77	4	CID000004220
Drug	SB 239063	MAPK14 MAPK12 MAPK3 MAPK11	2.13e-07	16	77	4	CID000005166
Drug	apocynin	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	2.22e-07	186	77	8	CID000002214
Drug	nickel hydroxide	MAPK14 MAPK12 DAPK1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2	2.28e-07	259	77	9	CID000025500
Drug	Go6983	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	2.33e-07	40	77	5	CID000003499
Drug	1c88	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	2.34e-07	126	77	7	CID000444766
Drug	Go6976	MAPK14 MAPK12 CYP27A1 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	2.61e-07	190	77	8	CID000003501
Drug	SF6847	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	2.64e-07	41	77	5	CID000005614
Drug	AEBSF	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 SOS1	2.72e-07	191	77	8	CID000001701
Drug	Ambotz208527-57-5	MAPK14 MAPK12 MAPK3 MAPK11	2.78e-07	17	77	4	CID010258704
Drug	kazinol B	MAPK14 MAPK12 MAPK11 RYR3	2.78e-07	17	77	4	CID000480869
Drug	NSC407322	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	3.06e-07	131	77	7	CID000003977
Drug	SB202190	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	3.57e-07	134	77	7	CID005353940
Drug	Nitrosomethylurethane	MAPK14 MAPK1 MAPK3	3.70e-07	5	77	3	ctd:D009605
Drug	AC1Q5V5T	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	3.75e-07	135	77	7	CID000004701
Drug	dehydroepiandrosterone sulfate	MAPK14 MAPK12 BBS4 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 LEPR	4.02e-07	277	77	9	CID000005244
Drug	geranylgeranyl pyrophosphate	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	4.57e-07	139	77	7	CID000000735
Drug	C11102	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11 MAP3K2	4.65e-07	86	77	6	CID000443069
Drug	AC1L45LU	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 TERT	4.66e-07	205	77	8	CID000151069
Drug	n-sulfo-2-aminotricarballylate	MAPK14 MAPK12 MAPK1 MAPK11	5.62e-07	20	77	4	CID000135808
Drug	AC1L1H7K	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	5.81e-07	144	77	7	CID000004010
Drug	vasopressin	MAPK14 MAPK12 ALMS1 PSMA2 TACR3 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	7.31e-07	388	77	10	CID011979316
Drug	vanadium	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	7.32e-07	149	77	7	CID000023990
Drug	methyl(acetoxymethyl)nitrosamine	MAPK14 MAPK1 MAPK3	7.38e-07	6	77	3	ctd:C014659
Drug	tolyltriazole	MAPK14 MAPK12 MAPK11	7.38e-07	6	77	3	CID000025902
Drug	arachidonic acid trifluoromethyl ketone	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	8.75e-07	153	77	7	CID000002224
Drug	inhibitor of p38 kinase	MAPK14 MAPK12 MAPK1 MAPK3 MAPK11	9.80e-07	53	77	5	CID000027933
Drug	sorafenib	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.09e-06	158	77	7	CID000216239
Drug	SKF86002	MAPK14 MAPK12 MAPK3 MAPK11	1.22e-06	24	77	4	CID000005228
Drug	Sorbitol	MAPK14 MAPK12 MAPK1 MAPK3	1.22e-06	24	77	4	ctd:D013012
Drug	octadec-9-en-1-amine	MAPK1 MAPK3 MAPK4 MAPK6	1.22e-06	24	77	4	CID000008219
Drug	baicalein	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.28e-06	162	77	7	CID005281605
Drug	Cp-38	MAPK14 MAPK12 MAPK11	1.29e-06	7	77	3	CID006918286
Drug	satratoxin H	MAPK14 MAPK12 MAPK11	1.29e-06	7	77	3	CID000434380
Drug	2,2',4,6-tetrachlorobiphenyl	MAPK14 MAPK12 MAPK11	1.29e-06	7	77	3	CID000044163
Drug	CID6325568	MAPK14 MAPK12 MAPK11	1.29e-06	7	77	3	CID006325568
Drug	poly(methyl methacrylate) (PMMA	ALMS1 MAPK1 MAPK3 MAPK4 MAPK6	1.29e-06	56	77	5	CID003032549
Drug	UV-C	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.34e-06	163	77	7	CID005289542
Drug	AC1L1GZB	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.57e-06	167	77	7	CID000003908
Drug	ciglitazone	MAPK14 MAPK12 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.70e-06	169	77	7	CID000002750
Drug	AC1NSK9Q	MAPK14 MAPK12 MAPK3 MAPK11	1.71e-06	26	77	4	CID005311233
Drug	U0126	MAPK14 MAPK12 DYNLL2 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 MAP3K2 SOS1	1.85e-06	430	77	10	CID000005637
Drug	calphostin C	SLC8A2 MAPK14 MAPK12 DYNLL2 TACR3 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	1.88e-06	431	77	10	CID000002533
Drug	AC1L1KS5	MAPK14 MAPK12 TACR3 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	1.90e-06	334	77	9	CID000005631
Drug	AC1L1KC5	SLC8A2 MAPK14 MAPK12 SACS STK17B MAPK1 MAPK3 MAPK4 MAPK6 MAPK11 RYR3	2.00e-06	541	77	11	CID000005428
Drug	Z-D-CH2DCB	MAPK14 MAPK12 MAPK11	2.06e-06	8	77	3	CID009911778
Drug	ML3403	MAPK14 MAPK12 MAPK11	2.06e-06	8	77	3	CID006419739
Drug	phytosphingosine	MAPK14 MAPK1 MAPK3	2.06e-06	8	77	3	ctd:C012491
Drug	CPS 11	MAPK14 MAPK1 MAPK3	2.06e-06	8	77	3	ctd:C494620
Drug	phenolate	MAPK14 MAPK12 PSMD3 MAPK1 MAPK3 MAPK4 MAPK6 MAPK11	2.33e-06	254	77	8	CID000000996
Drug	SB220025	MAPK14 MAPK12 MAPK1 MAPK11	2.69e-06	29	77	4	CID000005164
Disease	neurodevelopmental disorder with eye movement abnormalities and ataxia (implicated_via_orthology)	FRMD5 FRMD3	6.20e-06	2	74	2	DOID:0081275 (implicated_via_orthology)
Disease	Astrocytosis	MAPK1 MAPK3 LEPR	1.00e-05	17	74	3	C3887640
Disease	Gliosis	MAPK1 MAPK3 LEPR	1.00e-05	17	74	3	C0017639
Disease	hepatocellular clear cell carcinoma (is_marker_for)	TERT LEPR	1.86e-05	3	74	2	DOID:5016 (is_marker_for)
Disease	Cardiomyopathies	MAPK14 MAPK1 MAPK3 MAPK11 SOS1	1.94e-05	130	74	5	C0878544
Disease	Cardiomyopathies, Primary	MAPK14 MAPK1 MAPK3 MAPK11	2.78e-05	69	74	4	C0033141
Disease	Myocardial Diseases, Secondary	MAPK14 MAPK1 MAPK3 MAPK11	2.78e-05	69	74	4	C0036529
Disease	mitogen-activated protein kinase 12 measurement	MAPK12 MAPK11	3.71e-05	4	74	2	EFO_0020576
Disease	Subfertility, Female	MAPK1 MAPK3 LEPR	4.74e-05	28	74	3	C0341869
Disease	Sterility, Postpartum	MAPK1 MAPK3 LEPR	4.74e-05	28	74	3	C0038279
Disease	Female sterility	MAPK1 MAPK3 LEPR	4.74e-05	28	74	3	C0917730
Disease	Female infertility	MAPK1 MAPK3 LEPR	4.74e-05	28	74	3	C0021361
Disease	Cholestasis, Extrahepatic	MAPK14 MAPK1 MAPK3	7.13e-05	32	74	3	C0005398
Disease	CEROID LIPOFUSCINOSIS, NEURONAL, 6	MAPK1 MAPK3	9.25e-05	6	74	2	C1866282
Disease	Streptococcal pneumonia	MAPK1 MAPK3	9.25e-05	6	74	2	C0155862
Disease	age at menarche	ALMS1 MYO1H TACR3 MAPK1 MAPK3 HNF4G UNC79 LEPR	1.21e-04	594	74	8	EFO_0004703
Disease	endometrial adenocarcinoma (is_implicated_in)	MAPK1 MAPK3	1.29e-04	7	74	2	DOID:2870 (is_implicated_in)
Disease	type 2 diabetes mellitus (implicated_via_orthology)	ALMS1 MAPK1 MAPK3 LEPR	1.44e-04	105	74	4	DOID:9352 (implicated_via_orthology)
Disease	ureteral obstruction (implicated_via_orthology)	MAPK1 MAPK3	2.21e-04	9	74	2	DOID:5199 (implicated_via_orthology)
Disease	endometrial adenocarcinoma (is_marker_for)	MAPK1 MAPK3	3.36e-04	11	74	2	DOID:2870 (is_marker_for)
Disease	Trigeminal Neuralgia	MAPK1 MAPK3	4.03e-04	12	74	2	C0040997
Disease	chronic kidney disease (implicated_via_orthology)	TERT LEPR	4.03e-04	12	74	2	DOID:784 (implicated_via_orthology)
Disease	Secondary Trigeminal Neuralgia	MAPK1 MAPK3	4.03e-04	12	74	2	C0393787
Disease	Trigeminal Neuralgia, Idiopathic	MAPK1 MAPK3	4.03e-04	12	74	2	C0393786
Disease	Myeloproliferative disease	ATG2B TERT	4.03e-04	12	74	2	C0027022
Disease	Brain Ischemia	DYNLL1 MAPK1 MAPK3	4.68e-04	60	74	3	C0007786
Disease	Cerebral Ischemia	DYNLL1 MAPK1 MAPK3	4.68e-04	60	74	3	C0917798
Disease	Lung Neoplasms	MAPK14 DAPK1 MAPK1 MAPK3 TERT	5.47e-04	265	74	5	C0024121
Disease	gastric ulcer (implicated_via_orthology)	MAPK1 MAPK3	5.54e-04	14	74	2	DOID:10808 (implicated_via_orthology)
Disease	Malignant neoplasm of lung	MAPK14 DAPK1 MAPK1 MAPK3 TERT	5.56e-04	266	74	5	C0242379
Disease	Hypogonadotropic hypogonadism	TACR3 LEPR	6.38e-04	15	74	2	C0271623
Disease	Primary hypogonadism	TACR3 LEPR	6.38e-04	15	74	2	C0948896
Disease	Hypogonadism, Isolated Hypogonadotropic	TACR3 LEPR	6.38e-04	15	74	2	C3489396
Disease	serum albumin measurement	TNPO1 MPV17 SLC39A12 TERT LEPR FRMD5 SOS1	7.11e-04	592	74	7	EFO_0004535
Disease	Hypogonadism	TACR3 LEPR	7.28e-04	16	74	2	C0020619
Disease	Hypertrophy	MAPK1 MAPK3	9.25e-04	18	74	2	C0020564
Disease	Idiopathic hypogonadotropic hypogonadism	TACR3 FLRT3	9.25e-04	18	74	2	C0342384
Disease	Noonan-Like Syndrome With Loose Anagen Hair	SOS1 SOS2	1.03e-03	19	74	2	C3501846
Disease	Costello syndrome (disorder)	SOS1 SOS2	1.03e-03	19	74	2	C0587248
Disease	Noonan syndrome-like disorder with loose anagen hair	SOS1 SOS2	1.03e-03	19	74	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	SOS1 SOS2	1.03e-03	19	74	2	C1275081
Disease	Dystonia	MPV17 CYP27A1 MCOLN1	1.33e-03	86	74	3	C0013421
Disease	LEOPARD Syndrome	SOS1 SOS2	1.39e-03	22	74	2	C0175704
Disease	Septicemia	MAPK1 MAPK3	1.65e-03	24	74	2	C0036690
Disease	Sepsis	MAPK1 MAPK3	1.65e-03	24	74	2	C0243026
Disease	Severe Sepsis	MAPK1 MAPK3	1.65e-03	24	74	2	C1719672
Disease	Head Neoplasms	MAPK1 MAPK3	1.65e-03	24	74	2	C0018675
Disease	Upper Aerodigestive Tract Neoplasms	MAPK1 MAPK3	1.65e-03	24	74	2	C0887900
Disease	Pyemia	MAPK1 MAPK3	1.65e-03	24	74	2	C0034189
Disease	Noonan Syndrome	SOS1 SOS2	1.65e-03	24	74	2	C0028326
Disease	Cancer of Head	MAPK1 MAPK3	1.65e-03	24	74	2	C0751177
Disease	Neck Neoplasms	MAPK1 MAPK3	1.79e-03	25	74	2	C0027533
Disease	Cancer of Neck	MAPK1 MAPK3	1.79e-03	25	74	2	C0746787
Disease	colon adenocarcinoma (is_implicated_in)	MAPK1 MAPK3	1.94e-03	26	74	2	DOID:234 (is_implicated_in)
Disease	Kallmann Syndrome	TACR3 FLRT3	1.94e-03	26	74	2	C0162809
Disease	neutrophil count, eosinophil count	PSMD3 MAPK4 TERT LEPR	2.05e-03	213	74	4	EFO_0004833, EFO_0004842
Disease	obesity (implicated_via_orthology)	DCHS2 ALMS1 BBS4 LEPR	2.12e-03	215	74	4	DOID:9970 (implicated_via_orthology)
Disease	Myeloid Leukemia, Chronic	MAPK14 TERT	2.41e-03	29	74	2	C0023473
Disease	neutrophil count, basophil count	PSMD3 MAPK4 TERT LEPR	2.46e-03	224	74	4	EFO_0004833, EFO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
KQILNGVYYLHSLQI	DAPK1	121	P53355
FINILHRYYKSALVQ	PRKAG1	91	P54619
LYLQLGIYQKAFEHL	BBS4	211	Q96RK4
ALIIAGFVLYLYKHR	CSMD2	3421	Q7Z408
RQSYLIGLTLLHYLN	ABCA12	631	Q86UK0
NLLKVERIYLYHNSL	FLRT3	81	Q9NZU0
YSHREKLLVFYQQAL	ALMS1	811	Q8TCU4
IQFQRYNKLRHSVIY	ASPM	2231	Q8IZT6
YNKLRHSVIYIQAIF	ASPM	2236	Q8IZT6
YLLQRYLGHFLQEKL	ATG2B	16	Q96BY7
VVYYITHLLKGALLF	GPR107	331	Q5VW38
INLAKLKLFRHYYVL	GPR107	486	Q5VW38
VIRYLTFFHNYNILI	MCOLN1	401	Q9GZU1
YQILRGLKYIHSANV	MAPK1	131	P28482
HVQFLVYQLLRGLKY	MAPK11	126	Q15759
FLGLYINFRHLYKQR	HACD3	336	Q9P035
YQLLRGLKYIHSANV	MAPK4	131	P31152
HVQFLIYQILRGLKY	MAPK14	126	Q16539
IYQILRGLKYIHSAD	MAPK14	131	Q16539
KHFIYFYLGQVAILL	DYNLL1	71	P63167
LFMYQLLRGLKYIHS	MAPK6	131	Q16659
KNLLHERIVQYYGCL	MAP3K2	411	Q9Y2U5
LFRNYNYKVHLLYVL	LEPR	151	P48357
DHICYFLYQILRGLK	MAPK3	141	P27361
FLYQILRGLKYIHSA	MAPK3	146	P27361
AHQINIGYYLTLLFL	DZIP3	126	Q86Y13
YKDILLLGNNYVIHR	HNF4G	191	Q14541
ILYVYPKAFVQLRHL	LRRC70	96	Q7Z2Q7
YKQVGYLVLLHSLDR	DCHS2	2611	Q6V1P9
YLLYLQIKRDIFHGR	FRMD3	126	A2A2Y4
YLVFLQIKRDLYHGR	FRMD5	111	Q7Z6J6
VFKLRNHILYLIENY	DHX35	56	Q9H5Z1
GYALQLHQLQVLYKA	CYP27A1	76	Q02318
LLEFQILLYSQHYQR	DENND5A	306	Q6IQ26
VKIHITGLRNDYYLN	CDC20B	221	Q86Y33
VQRVSLLLLYYIIHQ	SLC39A12	111	Q504Y0
LKRFGNAVILLYIQH	SACS	4076	Q9NZJ4
YRPVYFQLVDVLLHK	IPO13	386	O94829
AIVYYLIQKFHSRAL	COA1	31	Q9GZY4
KHFIYFYLGQVAILL	DYNLL2	71	Q96FJ2
RLFQENLGLLHKYYV	PLEKHM2	111	Q8IWE5
FVRLYKAGLLYRNHQ	VARS2	261	Q5ST30
LYPLFVYLHLNLVQN	TAF5L	96	O75529
DLLKYYHQVTRAVLG	TAF6L	156	Q9Y6J9
IVTYALGIYHLNLFI	RER1	66	O15258
ILKLAGNYVFNIRHY	SOS2	141	Q07890
RLLAYVIFHLQYINP	TMCO5B	256	A8MYB1
EKVLHLYRSGQYLQN	PKDCC	386	Q504Y2
LQTIALLGYLKHYRN	SMARCA1	216	P28370
VAGIGFYQHLLLYIQ	SMG5	116	Q9UPR3
RYFRYILKQDHQILG	TAF1A	416	Q15573
FQLLVDYIYHGTVKL	KBTBD4	96	Q9NVX7
VYNIFRILLYHAIKY	NBEA	916	Q8NFP9
YYIAHLLKGALLFIT	GPR108	331	Q9NPR9
IRLIKQILEGVYYLH	STK17B	136	O94768
QLKIYTRLATIYHNF	SH3TC1	1276	Q8TE82
VQLANFYLVPLHYRL	MPV17	141	P39210
TDYLLVVNLHYGIRL	WDR17	236	Q8IZU2
HIYFILTAIYQQLNR	TACR3	316	P29371
ILKLVGNYVRNIRHY	SOS1	141	Q07889
VRIAHLVQYFFYKNL	ATP11C	871	Q8NB49
RRLNHYVLYKAVQGF	PSMD3	106	O43242
EIYQTKLLHYLARNF	RYR3	4396	Q15413
KYFRYNSLLIRHQII	ZNF620	231	Q6ZNG0
THGRYVLVIYENLLK	NDST2	131	P52849
LVHRARKLAQQYYLV	PSMA2	86	P25787
GLSKLQELVRYHIYN	STAB1	566	Q9NY15
YQLIEYLHKNLRVEG	ARHGAP19	126	Q14CB8
YYNVQIFLLLGQLLK	PKD2L2	336	Q9NZM6
YQHKNLLILYDAIGT	TNPO1	541	Q92973
YFYILASVILNVHLQ	SMIM10	66	Q96HG1
HLIRGQSVIKLYIIY	TAPT1	186	Q6NXT6
FLGIIRLYDYLQQLH	UBQLN3	336	Q9H347
IYKILLLQAYRFHAC	TERT	1001	O14746
ILLQYLILFQYLKGQ	THOC1	321	Q96FV9
NTVKRHLYVLLGYDQ	UNC79	1306	Q9P2D8
GYHRYKFIIKVLFIQ	DYNLT2	141	Q8IZS6
QFLVYQMLKGLRYIH	MAPK12	131	P53778
LEQLVGIANYYALLH	SLC8A2	331	Q9UPR5
FVRKNYILNLRYHLP	MYO1H	781	Q8N1T3
KHCRGYLVRSLYQLI	MYO5C	816	Q9NQX4