Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulator activity

ATG14 PRKD1

3.07e-0418292GO:0035014
GeneOntologyMolecularFunctionDNA damage sensor activity

XRCC3 RAD23B

5.51e-0424292GO:0140612
GeneOntologyCellularComponentphagophore assembly site membrane

ATG14 ATG9B

3.93e-0422282GO:0034045
GeneOntologyCellularComponentautophagosome

ATG14 ATG9B PRKD1

5.31e-04119283GO:0005776
GeneOntologyCellularComponentZ disc

PRKD1 ANK3 MYPN

1.06e-03151283GO:0030018
GeneOntologyCellularComponentphagophore assembly site

ATG14 ATG9B

1.24e-0339282GO:0000407
GeneOntologyCellularComponentI band

PRKD1 ANK3 MYPN

1.39e-03166283GO:0031674
GeneOntologyCellularComponentautophagosome membrane

ATG14 PRKD1

2.64e-0357282GO:0000421
GeneOntologyCellularComponentsarcomere

PRKD1 ANK3 MYPN

4.39e-03249283GO:0030017
MousePhenoabnormal upper lip morphology

SATB2 DISP1 RAD23B

1.89e-0537203MP:0012523
MousePhenoabnormal lip morphology

SATB2 DISP1 RAD23B

3.42e-0545203MP:0003769
DomainUBA

SIK3 RAD23B

2.11e-0344292IPR015940
DomainUBA

SIK3 RAD23B

2.41e-0347292PS50030
PathwayWP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH

ATG14 ATG9B CHAF1A

4.25e-0623203M39325
Pubmed

Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China.

XRCC3 RAD23B

4.02e-06429218708406
Pubmed

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

ATG14 CHAF1A

6.70e-06529218843052
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

SATB2 RBM27 ZNF281 PHC1 RAD23B

1.77e-0539629526687479
Pubmed

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells.

PRKD1 RAD23B

6.07e-051429220174665
Pubmed

Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.

EFR3B PRKD1

1.02e-041829223669352
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ATG14 SATB2 SIK3 ZNF281 MAML3

1.69e-0463829531182584
Pubmed

DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.

XRCC3 RAD23B

1.99e-042529220150366
Pubmed

The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.

ATG14 SATB2

3.08e-043129229099309
Pubmed

Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.

XRCC3 RAD23B

4.16e-043629218830263
Pubmed

A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.

XRCC3 RAD23B

4.39e-043729219116388
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

SATB2 MAML3 CHAF1A

4.73e-0418329336129980
Pubmed

Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.

PAPPA2 SATB2

5.66e-044229224997765
Pubmed

A human MAP kinase interactome.

USF3 SIK3 ANK3 CHAF1A

6.78e-0448629420936779
CytobandEnsembl 112 genes in cytogenetic band chr10q21

ANK3 MYPN

2.54e-03118292chr10q21
GeneFamilyAutophagy related

ATG14 ATG9B

6.01e-04332021022
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 PRKD1 SIK3 ANK3

6.60e-06189294830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

PRKD1 SIK3 ANK3 MAML3

7.62e-06196294ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

PRKD1 SIK3 ANK3 MAML3

7.93e-061982941996373bdccc55aac347d349bd22f6aad6d0c668
Diseasewaist-hip ratio

EFR3B PAPPA2 SIK3 ANK3 MAML3 ARHGAP21 PHC1

1.47e-041226297EFO_0004343
Diseasetriacylglycerol 54:3 measurement

SIK3 MYPN

4.26e-0431292EFO_0010421
Diseasepeak expiratory flow

PAPPA2 ANK3 TCP11 MYPN

1.36e-03498294EFO_0009718
Diseasecortical surface area measurement

SATB2 PRKD1 ANK3 ARHGAP21 CHAF1A RAD23B

1.71e-031345296EFO_0010736
Diseasetotal cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer

SIK3 MAML3

2.10e-0369292EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Diseasesmall cell lung carcinoma

FSTL4 PHC1

2.81e-0380292EFO_0000702
Diseasedescending aortic diameter

PAPPA2 SIK3

3.39e-0388292EFO_0021788

Protein segments in the cluster

PeptideGeneStartEntry
SQHVNLDQLQPLHTL

ATG14

361

Q6ZNE5
HPQVLQSFQQEHLPV

CHAF1A

821

Q13111
HFQHQPVQQHIANIR

DISP1

156

Q96F81
QLPVVLEQHVFQHLN

RAI2

121

Q9Y5P3
PQLLQQISQHQEHFI

RAD23B

311

P54727
PQHLHQQQVLVAQSA

RBM27

706

Q9P2N5
LAQVLPLDQNIQFHQ

NOX5

301

Q96PH1
QLRNEVAILQNLHHP

PRKD1

626

Q15139
EQQLQQSHLPRQHLQ

MAML3

776

Q96JK9
SIQPQHSHLVIQQLL

EFR3B

281

Q9Y2G0
NPLIINVTHHQNVLF

PAPPA2

1321

Q9BXP8
HPELVNHIVFENNQQ

GALNT5

891

Q7Z7M9
HEQLFQTHVLQVNVP

FSTL4

326

Q6MZW2
LHHILSQLQACIQPQ

IFNL1

121

Q8IU54
HLNCVQLLLQHNVPV

ANK3

346

Q12955
IYLHQLHQQQQQQEP

ATG9B

836

Q674R7
TSHIVQFPEIQHLLQ

MS4A14

421

Q96JA4
LLAHQHPQAINQQFL

SATB2

326

Q9UPW6
HHQILQQQIQDSICP

SIK3

686

Q9Y2K2
IQSLQPHLQEHSIQY

TCP11

211

Q8WWU5
DLSILHQHVQQQPAQ

ZNF281

176

Q9Y2X9
PHSLIQQQQQIHLQQ

PHC1

376

P78364
PHNVHQQRTLQQEVQ

USF3

1506

Q68DE3
HEQLQQPQPHLELQQ

ZNF853

106

P0CG23
HQVPHIQQAFEKVNQ

TEX28

86

O15482
PVNHLHQNSLLNQQT

ARHGAP21

651

Q5T5U3
IIPFLTQEHQQQVLQ

TLE2

91

Q04725
LQLHQQKERFPTQHQ

XRCC3

66

O43542
LHNQVLLEQHQLQNP

MYPN

666

Q86TC9