Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	lysosome	SORT1 LRRC8E LRRK2 VPS13A ELAPOR1 KCNQ1 MFSD8 LYN UVRAG HCK FFAR4 ATP6V0A2	4.42e-05	811	78	12	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	SORT1 LRRC8E LRRK2 VPS13A ELAPOR1 KCNQ1 MFSD8 LYN UVRAG HCK FFAR4 ATP6V0A2	4.42e-05	811	78	12	GO:0000323
GeneOntologyCellularComponent	lipid droplet	PNPLA2 RAB40AL VPS13A LSS RAB40A	7.37e-05	116	78	5	GO:0005811
GeneOntologyCellularComponent	endosome	SORT1 LHCGR TM9SF2 PLA2G4B RAB40AL LRRK2 VPS13A ELAPOR1 KCNQ1 MFSD8 RAB40A UVRAG FFAR4 ATP6V0A2	9.44e-05	1167	78	14	GO:0005768
GeneOntologyCellularComponent	vacuolar membrane	SORT1 LRRC8E VPS13A ELAPOR1 MFSD8 LYN UVRAG FFAR4 ATP6V0A2	1.12e-04	507	78	9	GO:0005774
GeneOntologyCellularComponent	vacuole	SORT1 LRRC8E LRRK2 VPS13A ELAPOR1 KCNQ1 MFSD8 LYN UVRAG HCK FFAR4 ATP6V0A2	1.37e-04	913	78	12	GO:0005773
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	SORT1 TM9SF2 PLA2G4B LRRK2 VPS13A ELAPOR1 KCNQ1 SYPL1 MFSD8 ZDHHC17 LYN FFAR4 ATP6V0A2 CXCR1	3.07e-04	1307	78	14	GO:0030659
GeneOntologyCellularComponent	lysosomal membrane	SORT1 LRRC8E VPS13A ELAPOR1 MFSD8 LYN FFAR4 ATP6V0A2	3.25e-04	462	78	8	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	SORT1 LRRC8E VPS13A ELAPOR1 MFSD8 LYN FFAR4 ATP6V0A2	3.25e-04	462	78	8	GO:0098852
GeneOntologyCellularComponent	vesicle membrane	SORT1 TM9SF2 PLA2G4B LRRK2 VPS13A ELAPOR1 KCNQ1 SYPL1 MFSD8 ZDHHC17 LYN FFAR4 ATP6V0A2 CXCR1	3.53e-04	1325	78	14	GO:0012506
GeneOntologyCellularComponent	transport vesicle	SORT1 RAB40AL LRRK2 KCNQ1 SYPL1 RAB40A HCK VDAC2	6.99e-04	519	78	8	GO:0030133
GeneOntologyCellularComponent	endosome membrane	SORT1 TM9SF2 PLA2G4B VPS13A ELAPOR1 MFSD8 FFAR4 ATP6V0A2	1.80e-03	602	78	8	GO:0010008
MousePheno	abnormal lysosome morphology	SORT1 LRRK2 MFSD8 HERC2 UVRAG	7.16e-06	61	62	5	MP:0005058
MousePheno	abnormal vacuole morphology	SORT1 LRRK2 MFSD8 HERC2 UVRAG	1.06e-05	66	62	5	MP:0020851
Domain	LRRC8_Pannexin-like	LRRC8E LRRC8D	1.75e-04	5	79	2	IPR021040
Domain	VPS10	SORT1 SORCS1	1.75e-04	5	79	2	SM00602
Domain	Pannexin_like	LRRC8E LRRC8D	1.75e-04	5	79	2	PF12534
Domain	Sortilin_C	SORT1 SORCS1	1.75e-04	5	79	2	PF15901
Domain	Sortilin-Vps10	SORT1 SORCS1	1.75e-04	5	79	2	PF15902
Domain	VPS10	SORT1 SORCS1	1.75e-04	5	79	2	IPR006581
Domain	Sortilin_N	SORT1 SORCS1	1.75e-04	5	79	2	IPR031778
Domain	Sortilin_C	SORT1 SORCS1	1.75e-04	5	79	2	IPR031777
Domain	SRCR_2	TMPRSS13 CORIN	3.66e-04	7	79	2	PF15494
Domain	PNT	ERG ETS1	9.48e-04	11	79	2	PS51433
Domain	Pointed_dom	ERG ETS1	9.48e-04	11	79	2	IPR003118
Domain	SAM_PNT	ERG ETS1	9.48e-04	11	79	2	PF02198
Domain	SAM_PNT	ERG ETS1	9.48e-04	11	79	2	SM00251
Domain	-	A2ML1 LSS	1.13e-03	12	79	2	1.50.10.20
Domain	Acyl_Trfase/lysoPLipase	PNPLA2 PLA2G4B	2.31e-03	17	79	2	IPR016035
Domain	Terpenoid_cyclase/PrenylTrfase	A2ML1 LSS	2.59e-03	18	79	2	IPR008930
Domain	WD40/YVTN_repeat-like_dom	SORT1 WDR75 TLE2 LRRK2 PWP2 EIF2A	2.95e-03	335	79	6	IPR015943
Domain	SOCS	RAB40AL RAB40A	3.19e-03	20	79	2	SM00253
Domain	FA58C	DDR2 RS1	3.52e-03	21	79	2	SM00231
Domain	FA58C_3	DDR2 RS1	3.52e-03	21	79	2	PS50022
Domain	FA58C_1	DDR2 RS1	3.52e-03	21	79	2	PS01285
Domain	FA58C_2	DDR2 RS1	3.52e-03	21	79	2	PS01286
Domain	-	DDR2 HERC2 RS1	3.66e-03	73	79	3	2.60.120.260
Domain	F5_F8_type_C	DDR2 RS1	4.59e-03	24	79	2	PF00754
Domain	FA58C	DDR2 RS1	4.59e-03	24	79	2	IPR000421
Domain	SR	TMPRSS13 CORIN	4.98e-03	25	79	2	SM00202
Domain	SRCR_1	TMPRSS13 CORIN	5.38e-03	26	79	2	PS00420
Domain	SRCR_2	TMPRSS13 CORIN	5.38e-03	26	79	2	PS50287
Domain	SRCR-like_dom	TMPRSS13 CORIN	5.38e-03	26	79	2	IPR017448
Domain	SRCR	TMPRSS13 CORIN	5.79e-03	27	79	2	IPR001190
Domain	WD40_repeat	WDR75 TLE2 LRRK2 PWP2 HERC2	5.92e-03	272	79	5	IPR001680
Domain	TyrKc	DDR2 LYN HCK	6.18e-03	88	79	3	SM00219
Domain	Tyr_kinase_cat_dom	DDR2 LYN HCK	6.18e-03	88	79	3	IPR020635
Domain	ETS_DOMAIN_1	ERG ETS1	6.22e-03	28	79	2	PS00345
Domain	ETS_DOMAIN_2	ERG ETS1	6.22e-03	28	79	2	PS00346
Domain	ETS	ERG ETS1	6.22e-03	28	79	2	SM00413
Domain	Ets_dom	ERG ETS1	6.22e-03	28	79	2	IPR000418
Domain	ETS_DOMAIN_3	ERG ETS1	6.22e-03	28	79	2	PS50061
Domain	Ets	ERG ETS1	6.22e-03	28	79	2	PF00178
Domain	WD_REPEATS_1	WDR75 TLE2 PWP2 HERC2 EIF2A	6.49e-03	278	79	5	PS00678
Domain	TRYPSIN_SER	CELA3A TMPRSS13 CORIN	6.57e-03	90	79	3	IPR033116
Domain	WD_REPEATS_2	WDR75 TLE2 PWP2 HERC2 EIF2A	6.58e-03	279	79	5	PS50082
Domain	WD_REPEATS_REGION	WDR75 TLE2 PWP2 HERC2 EIF2A	6.58e-03	279	79	5	PS50294
Domain	Galactose-bd-like	DDR2 HERC2 RS1	7.41e-03	94	79	3	IPR008979
Domain	7tm_1	LHCGR OR10A2 OR52E8 TAAR3P HCRTR2 FFAR4 CXCR1 OR10A5	7.76e-03	677	79	8	PF00001
Domain	PROTEIN_KINASE_TYR	DDR2 LYN HCK	8.08e-03	97	79	3	PS00109
Domain	Tyr_kinase_AS	DDR2 LYN HCK	8.08e-03	97	79	3	IPR008266
Domain	G_PROTEIN_RECEP_F1_1	LHCGR OR10A2 OR52E8 TAAR3P HCRTR2 FFAR4 CXCR1 OR10A5	8.31e-03	685	79	8	PS00237
Pathway	WP_GPCRS_OTHER	GHRHR OR10A2 TAAR3P ADGRF5 CXCR1 OR10A5	3.52e-06	93	63	6	M39629
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SORT1 SLC12A6 PNPLA2 TM9SF2 FKRP VPS13A SYPL1 LSS MFSD8 EIF2A LRRC8D ATP6V0A2	4.77e-06	1061	79	12	33845483
Pubmed	LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.	LYN HCK	5.09e-06	2	79	2	26517880
Pubmed	The long QT syndrome family of cardiac ion channelopathies: a HuGE review.	STK11 KCNQ1	5.09e-06	2	79	2	16540748
Pubmed	Human sorCS1 binds sortilin and hampers its cellular functions.	SORT1 SORCS1	5.09e-06	2	79	2	24128306
Pubmed	Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.	VPS13A LYN	5.09e-06	2	79	2	33941276
Pubmed	Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells.	ERG ETS1	5.09e-06	2	79	2	25885538
Pubmed	Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.	DDR2 LYN HCK	1.25e-05	20	79	3	7893599
Pubmed	Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells.	LYN HCK	1.53e-05	3	79	2	10749872
Pubmed	Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.	LYN HCK	1.53e-05	3	79	2	11238661
Pubmed	Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.	LYN HCK	1.53e-05	3	79	2	10684859
Pubmed	Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.	ETS1 LYN	1.53e-05	3	79	2	26209625
Pubmed	Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.	LYN HCK	1.53e-05	3	79	2	11698501
Pubmed	Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn.	LYN HCK	1.53e-05	3	79	2	9151903
Pubmed	Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.	FCRL4 HCK	1.53e-05	3	79	2	25972488
Pubmed	The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.	LYN HCK	1.53e-05	3	79	2	17513616
Pubmed	Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.	LYN HCK	1.53e-05	3	79	2	22393415
Pubmed	The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.	LYN HCK	1.53e-05	3	79	2	16140274
Pubmed	SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells.	LYN HCK	1.53e-05	3	79	2	14969582
Pubmed	HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.	LYN HCK	1.53e-05	3	79	2	16849330
Pubmed	The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.	LYN HCK	1.53e-05	3	79	2	25225462
Pubmed	Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors.	LYN HCK	1.53e-05	3	79	2	37089957
Pubmed	PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN.	PSTPIP2 LYN	1.53e-05	3	79	2	24407241
Pubmed	Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.	LYN HCK	1.53e-05	3	79	2	16772601
Pubmed	Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors.	LYN HCK	1.53e-05	3	79	2	17588471
Pubmed	Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells.	LYN HCK	1.53e-05	3	79	2	18346837
Pubmed	A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.	LYN HCK	3.05e-05	4	79	2	9314552
Pubmed	Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.	LYN HCK	3.05e-05	4	79	2	12496276
Pubmed	Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression.	ERG ETS1	3.05e-05	4	79	2	29773901
Pubmed	LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.	LRRC8E LRRC8D	3.05e-05	4	79	2	26824658
Pubmed	Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.	LYN HCK	3.05e-05	4	79	2	18246197
Pubmed	The genes for the human VPS10 domain-containing receptors are large and contain many small exons.	SORT1 SORCS1	3.05e-05	4	79	2	11499680
Pubmed	Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.	LYN HCK	3.05e-05	4	79	2	17183644
Pubmed	Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.	ERG ETS1	3.05e-05	4	79	2	23533276
Pubmed	The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita.	LYN HCK	3.05e-05	4	79	2	28576735
Pubmed	Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.	LYN HCK	3.05e-05	4	79	2	7859737
Pubmed	Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.	SORT1 SORCS1	3.05e-05	4	79	2	12482870
Pubmed	Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.	LYN HCK	3.05e-05	4	79	2	10642173
Pubmed	Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.	LYN HCK	3.05e-05	4	79	2	23447687
Pubmed	The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.	LYN HCK	3.05e-05	4	79	2	27358479
Pubmed	Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.	LYN HCK	3.05e-05	4	79	2	15491611
Pubmed	Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.	LRRC8E LRRC8D	3.05e-05	4	79	2	28193731
Pubmed	Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.	LYN HCK	3.05e-05	4	79	2	8058772
Pubmed	Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.	LYN HCK	3.05e-05	4	79	2	18625913
Pubmed	The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes.	LYN HCK	3.05e-05	4	79	2	10544125
Pubmed	LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.	LRRC8E LRRC8D	3.05e-05	4	79	2	33171122
Pubmed	TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells.	ERG ETS1	3.05e-05	4	79	2	18505930
Pubmed	Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line.	LYN HCK	5.07e-05	5	79	2	12896983
Pubmed	IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.	LYN HCK	5.07e-05	5	79	2	21220696
Pubmed	O-glycans direct selectin ligands to lipid rafts on leukocytes.	LYN HCK	5.07e-05	5	79	2	26124096
Pubmed	Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.	LYN HCK	5.07e-05	5	79	2	16425036
Pubmed	Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.	LRRC8E LRRC8D	5.07e-05	5	79	2	35777784
Pubmed	Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1.	LYN HCK	5.07e-05	5	79	2	22364282
Pubmed	Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.	ETS1 MED23	5.07e-05	5	79	2	15572696
Pubmed	Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa.	LYN HCK	5.07e-05	5	79	2	9268059
Pubmed	A contextual model for axonal sorting into glomeruli in the mouse olfactory system.	OR10A2 OR10A5	5.07e-05	5	79	2	15186781
Pubmed	LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.	LRRC8E LRRC8D	5.07e-05	5	79	2	15094057
Pubmed	Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.	LRRC8E LRRC8D	5.07e-05	5	79	2	24790029
Pubmed	Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.	LYN HCK	5.07e-05	5	79	2	15784897
Pubmed	RA70 is a src kinase-associated protein expressed ubiquitously.	LYN HCK	5.07e-05	5	79	2	9837776
Pubmed	Rab40b and Tks5 interact at invadopodia during metastasis.	RAB40AL RAB40A	5.07e-05	5	79	2	27909076
Pubmed	The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.	ERG ETS1	5.07e-05	5	79	2	9334186
Pubmed	Src family kinases mediate neutrophil adhesion to adherent platelets.	LYN HCK	5.07e-05	5	79	2	17095622
Pubmed	Activation of phospholipase Cgamma2 by tyrosine phosphorylation.	LYN HCK	5.07e-05	5	79	2	12181444
Pubmed	Murine txk: a protein tyrosine kinase gene regulated by T cell activation.	DDR2 LYN HCK	5.34e-05	32	79	3	7542761
Pubmed	Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.	LYN HCK	7.60e-05	6	79	2	10861086
Pubmed	Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.	PPIF VDAC2	7.60e-05	6	79	2	17417626
Pubmed	CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.	LYN HCK	7.60e-05	6	79	2	31594855
Pubmed	Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.	LYN HCK	7.60e-05	6	79	2	8657103
Pubmed	Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.	STK11 HERC2	7.60e-05	6	79	2	27259994
Pubmed	Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.	LYN HCK	7.60e-05	6	79	2	17218386
Pubmed	Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.	LYN HCK	7.60e-05	6	79	2	16684964
Pubmed	Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.	LYN HCK	7.60e-05	6	79	2	10586033
Pubmed	Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.	LYN HCK	7.60e-05	6	79	2	1720539
Pubmed	Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.	LYN HCK	7.60e-05	6	79	2	9890970
Pubmed	The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.	LYN HCK	7.60e-05	6	79	2	14993658
Pubmed	Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.	LYN HCK	1.06e-04	7	79	2	9020138
Pubmed	Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.	LYN HCK	1.06e-04	7	79	2	12538589
Pubmed	Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.	LYN HCK	1.06e-04	7	79	2	1689310
Pubmed	Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.	LYN HCK	1.06e-04	7	79	2	22511754
Pubmed	Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.	LYN HCK	1.06e-04	7	79	2	21860019
Pubmed	QM, a putative tumor suppressor, regulates proto-oncogene c-yes.	LYN HCK	1.06e-04	7	79	2	12138090
Pubmed	Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.	LYN HCK	1.06e-04	7	79	2	17086186
Pubmed	Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.	LYN HCK	1.06e-04	7	79	2	10858437
Pubmed	A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.	VPS13A LYN	1.06e-04	7	79	2	27742708
Pubmed	Proline-rich sequences that bind to Src homology 3 domains with individual specificities.	LYN HCK	1.06e-04	7	79	2	7536925
Pubmed	PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.	LYN HCK	1.41e-04	8	79	2	18794338
Pubmed	The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.	LYN HCK	1.41e-04	8	79	2	21309750
Pubmed	Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo.	LYN HCK	1.41e-04	8	79	2	27032818
Pubmed	The mutational landscape of lethal castration-resistant prostate cancer.	ERG ASH2L	1.41e-04	8	79	2	22722839
Pubmed	The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.	LYN HCK	1.41e-04	8	79	2	26777396
Pubmed	A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.	LYN HCK	1.41e-04	8	79	2	9687507
Pubmed	The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.	LYN HCK	1.41e-04	8	79	2	23896410
Pubmed	The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.	LYN HCK	1.41e-04	8	79	2	19255189
Pubmed	Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.	LYN HCK	1.41e-04	8	79	2	16921024
Pubmed	Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.	LYN HCK	1.41e-04	8	79	2	20304029
Pubmed	Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.	ERG ETS1	1.41e-04	8	79	2	9681824
Pubmed	Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling.	LYN HCK	1.41e-04	8	79	2	8885868
Pubmed	Genomic analysis of orthologous mouse and human olfactory receptor loci.	OR10A2 OR10A5	1.82e-04	9	79	2	11416212
Pubmed	Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.	LYN HCK	1.82e-04	9	79	2	19273622
Pubmed	In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases.	LYN HCK	1.82e-04	9	79	2	7682059
Cytoband	15q13	SLC12A6 HERC2	1.04e-04	9	79	2	15q13
Cytoband	18q12	PSTPIP2 MOCOS	2.25e-04	13	79	2	18q12
Cytoband	21q22.3	ERG PWP2 LSS	1.43e-03	128	79	3	21q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	PNPLA2 OR10A2 OR52E8 KCNQ1 OR10A5	2.94e-03	564	79	5	chr11p15
GeneFamily	Volume regulated anion channel subunits	LRRC8E LRRC8D	8.07e-05	5	52	2	1158
Coexpression	GSE11924_TH1_VS_TH17_CD4_TCELL_DN	LRRK2 SLCO3A1 SYPL1 PSTPIP2 HCK VDAC2 MOCOS	2.19e-06	199	78	7	M3163
CoexpressionAtlas	Myeloid Cells, DC.8+.Sp, CD11b CD4 CD45 CD11c CD8a, Spleen, avg-2	LRRK2 SLCO3A1 RP2 PSTPIP2 LY75 LYN UVRAG HCK FFAR4	1.05e-05	407	73	9	GSM538258_500
CoexpressionAtlas	Myeloid Cells, DC.4+.SLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3	SORT1 LRRK2 RP2 PSTPIP2 LYN UVRAG HCK FFAR4	7.70e-05	407	73	8	GSM538245_500
CoexpressionAtlas	Myeloid Cells, DC.8+.Sp, CD11b CD11c CD45 CD8a CD4, Spleen, avg-2	LRRK2 ADGRF5 RP2 PSTPIP2 LY75 LYN HCK FFAR4	8.38e-05	412	73	8	GSM538260_500
ToppCell	BL-critical-LOC-Myeloid\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRK2 DDX60L PSTPIP2 LYN HCK PPIF CXCR1	6.16e-08	197	79	7	932a7fae4979b561688e6222505df0f4e510ab11
ToppCell	NS-moderate-d_16-33-Myeloid-Neutrophil\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRK2 DDX60L LYN HCK PPIF CXCR1	1.20e-06	192	79	6	545c3990cbe3c04bfd95a0ab7499d2c4af509be1
ToppCell	moderate-Myeloid-Neutrophil\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRK2 DDX60L LYN HCK PPIF CXCR1	1.20e-06	192	79	6	8105408400dac5dcb0ce62b558433257559c9f09
ToppCell	COVID-19-kidney-Myeloid\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC12A6 DDX60L PSTPIP2 LYN HCK CXCR1	1.20e-06	192	79	6	0b9d22a222f1201e375f8e55cace9ef939febae4
ToppCell	BL-critical-LOC-Myeloid-Neutrophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRK2 DDX60L LYN HCK PPIF CXCR1	1.35e-06	196	79	6	f64d7fed31e418c55fe946744d78c3cbecec9bbf
ToppCell	severe-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	LRRK2 DDX60L PSTPIP2 LYN HCK CXCR1	1.39e-06	197	79	6	3b71e523d8a68f131def17233385df371db70db5
ToppCell	NS-critical-d_07-13-Myeloid-Neutrophil\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRK2 DDX60L LYN HCK PPIF CXCR1	1.39e-06	197	79	6	f38037dfa6c33e9336130d0cc65eaba0f120efb9
ToppCell	NS-critical-d_07-13-Myeloid\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRK2 DDX60L LYN HCK PPIF CXCR1	1.43e-06	198	79	6	08bc3f63a5c5b65bff10aadebdaa5e7f192cda01
ToppCell	critical-Myeloid-Neutrophil\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRK2 DDX60L LYN HCK PPIF CXCR1	1.43e-06	198	79	6	4da73dc3acb29d70b160903600d2bf7fdab34333
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 ADGRF5 TMEM252 LY75	3.96e-06	133	79	5	bc29a2faa151b0e48c1c7e3f016cccc49f9a15eb
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 ADGRF5 TMEM252 LY75	5.64e-06	143	79	5	35d3652680c4dddd293301595d813161c66e5673
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 ADGRF5 TMEM252 LY75	8.09e-06	154	79	5	b0735365de153d4586ca17896431d7bd9c7d8eac
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LHCGR EYS ELAPOR1 SLCO3A1 FCRL4	1.63e-05	178	79	5	0b59e3d75b143bd7bf91a7800a49699c51e68c5a
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 PSTPIP2 LYN HCK HCRTR2	1.77e-05	181	79	5	14faef1dde781d501834379f2a6413e8d6a80b72
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	STK11 FKRP KCNQ1 PSTPIP2 MED23	1.86e-05	183	79	5	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	STK11 FKRP KCNQ1 PSTPIP2 MED23	1.86e-05	183	79	5	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRK2 DDX60L PSTPIP2 LYN HCK	1.96e-05	185	79	5	f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2ML1 ELAPOR1 KCNQ1 PSTPIP2 HCK	1.96e-05	185	79	5	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC12A6 LRRK2 PSTPIP2 LYN HCK	2.29e-05	191	79	5	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	NS-critical-d_0-4-Myeloid-Neutrophil\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRK2 DDX60L LYN PPIF CXCR1	2.34e-05	192	79	5	3db74359c30172a51177e00eac1f48f483e15578
ToppCell	mild-Myeloid-Neutrophils_1\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SLC12A6 LRRK2 LYN HCK CXCR1	2.46e-05	194	79	5	ccd911ce3251cd1c60f1fb2ce00650fbe7a379bb
ToppCell	COVID_vent-Myeloid-Monocytic-Neutrophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	LRRK2 DDX60L LYN HCK CXCR1	2.46e-05	194	79	5	eb23b171e429165dd26a64377eae7fa2ce25f547
ToppCell	CF-Myeloid\|CF / Disease state, Lineage and Cell class	SLCO3A1 DDX60L LYN HCK PPIF	2.52e-05	195	79	5	ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCell	control-Myeloid-Neutrophils_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SLC12A6 LRRK2 LYN HCK CXCR1	2.59e-05	196	79	5	9c8623232c47af5de9f360fd5c5113362e37c6c9
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRK2 DDX60L LYN PPIF CXCR1	2.59e-05	196	79	5	d9b5eaca4089d5337f1175a663418c9c675cdd87
ToppCell	mild-Myeloid-Neutrophils_2\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	LRRK2 DDX60L LYN HCK CXCR1	2.59e-05	196	79	5	e9f30eb8a3915c3b2af009c832bff9b349b65ae5
ToppCell	Control-Myeloid-TRAM3\|Control / Disease group,lineage and cell class （2021.01.30）	SORT1 DDX60L LYN HCK PPIF	2.65e-05	197	79	5	733ff40039d67e561c2ded7c9bd0b4353101741e
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_interstitial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDX60L PSTPIP2 LYN HCK PPIF	2.65e-05	197	79	5	1a30747a2188a890f58d831030328986b3a4356d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRK2 DDX60L LYN PPIF CXCR1	2.65e-05	197	79	5	037f5f26fa66818baa35846aa96336155e8a6f45
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SORT1 DDX60L LYN HCK PPIF	2.65e-05	197	79	5	4416efdbd9c4ac3356a5dff2d535c2d7383376a9
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRK2 DDX60L HCK PPIF CXCR1	2.65e-05	197	79	5	340ce4fef244176fb52e38ffbcbdfda5ac3467dd
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SORT1 DDX60L LYN HCK PPIF	2.65e-05	197	79	5	0f1c4a328968b32874e6ebb0803e665adcbbc450
ToppCell	critical-Myeloid-Neutrophil\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRK2 DDX60L LYN PPIF CXCR1	2.65e-05	197	79	5	f1248781e71e3a158d06e9ec93eb90dc6d48bcb2
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SORT1 DDX60L LYN HCK PPIF	2.65e-05	197	79	5	aafe0cd697b0b7f0756596148e0906443fdf8ef7
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SORT1 DDX60L LYN HCK PPIF	2.65e-05	197	79	5	e131634bc67e0bd31a938a8e8df8dc752e1d0f47
ToppCell	severe-Others-Megakaryocytes\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	LRRK2 DDX60L LYN HCK CXCR1	2.65e-05	197	79	5	fc0864e2de2d9f99084586b467551b6da535d933
ToppCell	critical-Myeloid\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRK2 DDX60L LYN HCK PPIF	2.72e-05	198	79	5	a5807517f8ca93b77f49f5787fd9036178b8fc2a
ToppCell	COVID-19_Severe-Neu_1\|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients	LRRK2 DDX60L LYN HCK CXCR1	2.72e-05	198	79	5	bbe639ea5a636c985e509fb0a133ae3b60afac5a
ToppCell	severe-Myeloid\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	LRRK2 DDX60L LYN HCK CXCR1	2.72e-05	198	79	5	d19902a6353445f9875dec59933b7553f5145b8b
ToppCell	moderate-Myeloid-Neutrophil\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRK2 DDX60L LYN PPIF CXCR1	2.72e-05	198	79	5	a6306dac34af5783f3a734ef1eaa7a0c03267b4f
ToppCell	NS-critical-d_0-4-Myeloid\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRK2 DDX60L LYN HCK PPIF	2.72e-05	198	79	5	72d51284d267f102c26f0ae8279ee9e11e69c7e3
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LRRK2 PSTPIP2 LYN HCK CXCR1	2.78e-05	199	79	5	8c2ab13b5fffbab3da37041a7000d6537fc4db09
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_interstitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DDX60L PSTPIP2 LYN HCK PPIF	2.78e-05	199	79	5	841338719d042247966867ac608146395eb8c4d9
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LRRK2 PSTPIP2 LYN HCK CXCR1	2.85e-05	200	79	5	1592ca96c59eb053d0f0915afb337db9f3a40c91
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRRK2 PSTPIP2 LYN HCK CXCR1	2.85e-05	200	79	5	6beabd5bad042d4d65c89c2f537c7376230f7c08
ToppCell	severe-Neutrophil\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LRRK2 DDX60L LYN HCK CXCR1	2.85e-05	200	79	5	f9af7e77a8483ab4ae708b55514e64f5420fa0c1
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRRK2 PSTPIP2 LYN HCK CXCR1	2.85e-05	200	79	5	026495aa7f1e7528a01d9199475cfc393677fc60
ToppCell	COVID_non-vent\|World / Disease condition, Lineage, Cell class and subclass	SORT1 LRRK2 DDX60L LYN HCK	2.85e-05	200	79	5	accef1050963dc91e189ac3d38228f15bf57e06e
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	6.00e-05	119	79	4	a3807e738d7ca8cf80aa4bd35e3ee4357b1dc00f
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	6.00e-05	119	79	4	8a3f0a3ed9f80d7b061162e9fa519bb09804a86c
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	6.00e-05	119	79	4	938da0fe90372709048bf4e5503cc1cbf8376b17
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Cartpt_(Neuron.Gad1Gad2.Pvalb-Cartpt)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TMPRSS13 RS1 FFAR4	7.99e-05	47	79	3	ae7c9e110228e142662a671f13f0069494949791
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Cartpt_(Neuron.Gad1Gad2.Pvalb-Cartpt)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TMPRSS13 RS1 FFAR4	7.99e-05	47	79	3	e5c448273e5ceb9bb08fb10ce362a4da003d7172
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	8.71e-05	131	79	4	d46bb28612b9690b2e3550b8adbd10781788c00d
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	8.71e-05	131	79	4	308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	8.97e-05	132	79	4	06e7337de35bd7120655a22b6020604ad004c4e1
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	1.04e-04	137	79	4	306b11b3b9e5fd562d845fb5eaa4ac982864efce
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK\|Striatum / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	1.04e-04	137	79	4	d37f425b13bc046baa1f8619b98a16b936f88ff6
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS CELA3A ELAPOR1 FFAR4	1.58e-04	153	79	4	20786807bba3bcd70ce744f8b6454e064199ed9f
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	SORT1 LYN HCK FFAR4	1.71e-04	156	79	4	1a0e081284a99c1b345990775015b8a2fa469496
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ERG KCNQ1 TMEM252 LY75	1.88e-04	160	79	4	04714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NADK2 ELAPOR1 LSS CXCR1	1.88e-04	160	79	4	70f3637dd0bcfcef421aa114f946fff0048f192e
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERG ETS1 ADGRF5 TMEM252	1.93e-04	161	79	4	a60ef3f390f56bb05b687b17986fe6382f69f260
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERG ETS1 ADGRF5 TMEM252	1.97e-04	162	79	4	0bdb1e5ba33e162bec1acb28256c1405a7658ee5
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERG ETS1 ADGRF5 TMEM252	1.97e-04	162	79	4	5799a602ef8d83925907e8e34532428be7330228
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERG ADGRF5 TMEM252 LY75	2.07e-04	164	79	4	6a41a159134e605b80d5e731f9ed5bc803bb531b
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERG ADGRF5 TMEM252 LY75	2.07e-04	164	79	4	ec68954fc09b6850273b5e59caa6b09d02151097
ToppCell	B_cells-ABCs\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	GHRHR FCRL4 LYN HCK	2.07e-04	164	79	4	f45013706a917f0f0d69c23f288128f252cd60c7
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic-dendritic_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRRK2 PSTPIP2 RS1 HCK	2.07e-04	164	79	4	3088d5fa240d2f4a6e21281f7ac932aea2f9af49
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERG ADGRF5 TMEM252 LY75	2.16e-04	166	79	4	27af6c906cff1d40d134f0386db7708869691121
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRRK2 PSTPIP2 RS1 HCK	2.16e-04	166	79	4	479391aa6c09aa070b716128ab51b8fec0aea22d
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LY75 LRRC8D FFAR4 CXCR1	2.27e-04	168	79	4	a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell	droplet-Lung-nan-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 ADGRF5 TMEM252 CXCR1	2.32e-04	169	79	4	f0f97ca415aef619b8b4b1399ad5e0823267516e
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor-MUC5AC+ASCL1+_intermediate_\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PNPLA2 ELAPOR1 RS1 KLB	2.37e-04	170	79	4	d6e244725b21592c6056b9c443aac090f1eae836
ToppCell	droplet-Lung-18m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ETS1 ADGRF5 TMEM252 CXCR1	2.37e-04	170	79	4	683c4aa74689791944b6f3998dba51a4456fbc49
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO3A1 PSTPIP2 DNAH5 HCK	2.37e-04	170	79	4	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 ETS1 LYN HCK	2.37e-04	170	79	4	6086d658a52a1961a1e293cbc3703ae8d309cd11
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9\|TCGA-Bladder / Sample_Type by Project: Shred V9	SLC12A6 TM9SF2 SLCO3A1 SYPL1	2.42e-04	171	79	4	adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELA3A VPS13A ELAPOR1 SLCO3A1	2.42e-04	171	79	4	c54dcad75fc378da1943009d7dd872b39ea337c0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ERG ETS1 SLCO3A1 ADGRF5	2.53e-04	173	79	4	f193c63cc536d891c9d23043765e320252bb6e65
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Cilia-bearing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	B9D2 FKRP PWP2 RFNG	2.53e-04	173	79	4	d4cbeae262abfa30d8c5452285d3261a96875610
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO3A1 PSTPIP2 DNAH5 HCK	2.53e-04	173	79	4	f0eb48c1283bdde313bb75f6ffc0d2626922d24b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1-2_PAX6_SCGN\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLE2 DDR2 ZNF726 HCRTR2	2.53e-04	173	79	4	33170a1cc0bc87504d0501fc257a32ff17e02314
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO3A1 PSTPIP2 DNAH5 HCK	2.65e-04	175	79	4	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	(03)_Secretory\|World / shred by cell type and Timepoint	SORT1 ELAPOR1 KCNQ1 FFAR4	2.70e-04	176	79	4	cb7b1945788196ca79007f0768b6576ec885a0e5
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERG ETS1 ADGRF5 TMEM252	2.70e-04	176	79	4	eb63eb2c301e785196ccadac74a2940b2c524c62
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 PSTPIP2 HCK MOCOS	2.76e-04	177	79	4	065bebd22031f143e90a407f952b444a3f8818c7
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHCGR ELAPOR1 KLB SORCS1	2.76e-04	177	79	4	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	facs-Marrow-Granulocytes-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 PSTPIP2 HCK MOCOS	2.76e-04	177	79	4	eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHCGR ELAPOR1 KLB SORCS1	2.76e-04	177	79	4	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELA3A VPS13A ELAPOR1 FFAR4	2.76e-04	177	79	4	c80893e5cf5688ee9f5afc8f11b3890f296c9e1f
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ELAPOR1 KCNQ1 PSTPIP2 HCK	2.82e-04	178	79	4	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 HCK FFAR4 ATP6V0A2	2.82e-04	178	79	4	ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCell	Severe-Myeloid-Neutrophil\|Severe / Condition, Lineage, Cell class and cell subclass	DDX60L LYN PPIF CXCR1	2.82e-04	178	79	4	454313efe59d71e7327b9758efabf2d893e4a8fd
ToppCell	Severe-Myeloid-Neutrophil-\|Severe / Condition, Lineage, Cell class and cell subclass	DDX60L LYN PPIF CXCR1	2.82e-04	178	79	4	8618ae891d62bf70fe860ff7bb2d31868961aa13
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 HCK FFAR4 ATP6V0A2	2.82e-04	178	79	4	6c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 HCK FFAR4 ATP6V0A2	2.82e-04	178	79	4	cd85dcefe94ee742db64b63e105e13532321894a
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO3A1 PSTPIP2 DNAH5 HCK	2.82e-04	178	79	4	09a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRK2 LYN HCK CXCR1	2.82e-04	178	79	4	94a86f5232fffa6a92a30ea21fb44eec33b4d6c8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ERG ETS1 ADGRF5 RS1	2.88e-04	179	79	4	8f9e538c822940785130297712b75131812a4603
Disease	colorectal cancer (implicated_via_orthology)	LYN UVRAG HCK	6.09e-05	30	75	3	DOID:9256 (implicated_via_orthology)
Disease	kidney disease (implicated_via_orthology)	LYN HCK KLB	1.57e-04	41	75	3	DOID:557 (implicated_via_orthology)
Disease	N-acetylmethionine measurement	SLCO3A1 FFAR4	6.55e-04	15	75	2	EFO_0021427
Disease	quinate measurement	LRRK2 KCNQ1	6.55e-04	15	75	2	EFO_0021167
Disease	triacylglycerol 50:5 measurement	LRRC8E YIPF5	7.48e-04	16	75	2	EFO_0010412
Disease	hippuric acid measurement	A2ML1 RAB40A	1.06e-03	19	75	2	EFO_0010496
Disease	mean platelet volume	SLC12A6 ATAD5 LRRK2 KCNQ1 ADGRF5 LY75 LYN LRRC8D PPIF	1.11e-03	1020	75	9	EFO_0004584
Disease	response to radiation	ELAPOR1 PSTPIP2 DNAH5	1.48e-03	88	75	3	GO_0009314
Disease	Disorder of eye	EYS MFSD8 RP2 RS1	2.11e-03	212	75	4	C0015397

Protein segments in the cluster

Peptide	Gene	Start	Entry
DFSWTNGKVTSGLCD	ATAD5	1676	Q96QE3
NSSCITWEGTNGEFK	ERG	326	P11308
WTTFFKGERVTLTCN	FCRL4	31	Q96PJ5
GEFSCTLTKYWNRGF	ABCA6	161	Q8N139
GNGNTWLTAFVTKCF	A2ML1	1031	A8K2U0
KAAIGSVFSSWLCGA	ACSM4	276	P0C7M7
QCGICTKWFTADTFG	ASH2L	116	Q9UBL3
KLWDTSGQGRFCTIF	RAB40A	66	Q8WXH6
KLWDTSGQGRFCTIF	RAB40AL	66	P0C0E4
FKGNFWSADILSTIG	PSTPIP2	6	Q9H939
TVTTVKFWFATGGAG	RFNG	191	Q9Y644
FQTCFTFLGEKGVTW	MFSD8	186	Q8NHS3
KTWNISFAGCGFLGV	PNPLA2	6	Q96AD5
QTWVGKTIASCFSVF	KCNQ1	321	P51787
IDWQTGSGCSTAGFF	LHCGR	431	P22888
DCWFLGVNTKIDTSG	EYS	56	Q5T1H1
CTTGWKGSFCTETVS	EYS	2636	Q5T1H1
CTGTGSKAWSFNINR	NADK2	311	Q4G0N4
LGKFTTASDVWAFGV	DDR2	761	Q16832
IECAKWLQSSIFSGG	HERC2	1331	O95714
DFWLKVGISAGTCTA	ELAPOR1	906	Q6UXG2
TEFSGCLSQDWKLFL	DDX60L	121	Q5H9U9
TDKSCQSFISWTGDG	ETS1	346	P14921
CFWFPEKGAILTDTS	FFAR4	336	Q5NUL3
GFSFSTLDCGWIVSD	LSS	441	P48449
FTGSDSIQGTWCKDI	MED23	701	Q9ULK4
WGGCGTKIFSFSNDF	LRRK2	2316	Q5S007
GLSTDGFWDIQTFKV	LY75	1351	O60449
FSGEWSEFCKLVLSS	METTL18	266	O95568
CGEKISSWLSTFFGR	MOCOS	686	Q96EN8
VCTSFWFKFPGTSSK	LRRC8E	131	Q6NSJ5
TKGQSLTTFEFGEWC	PLA2G4B	441	P0C869
WFTVEFGLCKQGDSI	PAH	326	P00439
QTTWLFSFPFCGTNK	OR10A2	146	Q9H208
ITETWFFGQSLCKVI	HCRTR2	116	O43614
VFGCGTLLSFSQSSW	ICMT	76	O60725
FGSFTIKSDVWSFGI	HCK	431	P08631
TSFVSAFGCNFIWKP	CELA3A	236	P09093
AASKVNGWIFGTFLC	CXCR1	96	P25024
FGLTSWGSVCFSKVL	CORIN	1001	Q9Y5Q5
FTGTWVSCKLAFEDI	GHRHR	256	Q02643
NFGCFTIKSDVWSFG	LYN	416	P07948
FPCDFSWGVTESVLK	KLB	521	Q86Z14
TFSFCLESDWAGGVK	EME1	456	Q96AY2
VCIFSKDGTLFAWGN	EIF2A	41	Q9BY44
WFGCNKETTRCFGTV	FKRP	286	Q9H9S5
IGASGFSESSLFCKW	B9D2	11	Q9BPU9
VPSKLWGFFCNSSQF	SLC12A6	401	Q9UHW9
CWAGTQETTDIKGLF	C4orf51	91	C9J302
KFPALISGCTIDWFS	DNAH5	3101	Q8TE73
FVSILGKCFESPWTT	LRRC8D	196	Q7L1W4
TTWLFSFPFCGTNKV	OR10A5	161	Q9H207
FWFNTKEISFGGCLS	OR52E8	91	Q6IFG1
WIASIFAFATCGGFK	SYPL1	41	Q16563
LTFNKFWGTILFTTC	TAAR3P	191	Q9P1P4
LDTSVSCFVVKIWGG	UVRAG	106	Q9P2Y5
VCLAKWGSDNTIFFT	SORT1	256	Q99523
LIFGAGIDSTCLFWS	SLCO3A1	591	Q9UIG8
GSQFFICTIKTDWLD	PPIF	151	P30405
FSGFKVDIWSAGVTL	STK11	231	Q15831
SPSGGETKCVFWNFR	ADGRF5	946	Q8IZF2
KDCGKAFNWFSTLTT	ZNF100	236	Q8IYN0
FVTKGTFGQLTCEWQ	VPS13A	3096	Q96RL7
TFSLNETCWITGFGK	TMPRSS13	441	Q9BYE2
WLLAKSGCEVTFNGT	TMEM143	401	Q96AN5
TKAAFGCFGNWLATV	WDR75	391	Q8IWA0
KVKVWNTLSGFCFVT	PWP2	396	Q15269
ECFLVWGAQAFTSGK	TRIM51	326	Q9BSJ1
IIESSSNIKFGCFQW	RP2	136	O75695
WTSGTNCTRFGIAAK	VDAC2	221	P45880
FFISWGSIFDCQGSL	TMEM252	26	Q8N6L7
KEGLCTQGSSFSWLL	TBC1D29P	6	Q9UFV1
LTAGIIGWCSFSASK	YIPF5	211	Q969M3
IGWCSFSASKIFISA	YIPF5	216	Q969M3
GGVWATVQFLSKSFF	ZDHHC17	336	Q8IUH5
DECGKSFIWSSTLFK	ZNF726	596	A6NNF4
TGTIGFFACFWFVTK	TM9SF2	641	Q99805
QGFGCAWLSKFQDSS	RS1	106	O15537
FWFNPSSLSKDCSLG	SORCS1	746	Q8WY21
SLKFASCGRWFVSTG	TLE2	676	Q04725
CFSKSVNLFGSGWNV	ATP6V0A2	471	Q9Y487