Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	AGAP7P AGAP4 AGAP6 PREX2 AGAP3	2.01e-04	279	39	5	GO:0005096
GeneOntologyMolecularFunction	protein serine/threonine phosphatase inhibitor activity	PPP1R14A PPP1R14C	3.84e-04	15	39	2	GO:0004865
GeneOntologyMolecularFunction	GTPase regulator activity	AGAP7P AGAP4 AGAP6 PREX2 ARHGEF9 AGAP3	4.16e-04	507	39	6	GO:0030695
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	AGAP7P AGAP4 AGAP6 PREX2 ARHGEF9 AGAP3	4.16e-04	507	39	6	GO:0060589
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF13B AGAP7P DNAH10 AGAP4 AGAP6 DHX8 AGAP3	6.71e-04	775	39	7	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	KIF13B AGAP7P DNAH10 AGAP4 AGAP6 DHX8 AGAP3	1.07e-03	839	39	7	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KIF13B AGAP7P DNAH10 AGAP4 AGAP6 DHX8 AGAP3	1.08e-03	840	39	7	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KIF13B AGAP7P DNAH10 AGAP4 AGAP6 DHX8 AGAP3	1.08e-03	840	39	7	GO:0016818
GeneOntologyMolecularFunction	enzyme regulator activity	PPP1R14A FIP1L1 AGAP7P AGAP4 PPP1R14C AGAP6 PREX2 ARHGEF9 AGAP3	1.35e-03	1418	39	9	GO:0030234
GeneOntologyMolecularFunction	GTPase activity	AGAP7P AGAP4 AGAP6 AGAP3	4.29e-03	341	39	4	GO:0003924
GeneOntologyMolecularFunction	protein phosphatase inhibitor activity	PPP1R14A PPP1R14C	4.29e-03	50	39	2	GO:0004864
GeneOntologyMolecularFunction	phosphatase inhibitor activity	PPP1R14A PPP1R14C	4.99e-03	54	39	2	GO:0019212
GeneOntologyMolecularFunction	ATP-dependent activity	KIF13B MSH6 DNAH10 CECR2 DHX8	6.56e-03	614	39	5	GO:0140657
GeneOntologyMolecularFunction	GTP binding	AGAP7P AGAP4 AGAP6 AGAP3	7.31e-03	397	39	4	GO:0005525
GeneOntologyMolecularFunction	modification-dependent protein binding	FAM156A MSH6 AGAP3	7.53e-03	206	39	3	GO:0140030
GeneOntologyMolecularFunction	microtubule motor activity	KIF13B DNAH10	8.26e-03	70	39	2	GO:0003777
GeneOntologyMolecularFunction	enzyme activator activity	AGAP7P AGAP4 AGAP6 PREX2 AGAP3	8.62e-03	656	39	5	GO:0008047
GeneOntologyBiologicalProcess	activation of GTPase activity	AGAP7P AGAP4 AGAP6 AGAP3	5.26e-05	109	39	4	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	AGAP7P AGAP4 AGAP6 PREX2 AGAP3	9.22e-05	244	39	5	GO:0043547
MousePheno	abnormal cornea morphology	ANKRD35 AGAP7P IK AGAP4 AGAP6 ESYT1 ZC3H13	7.56e-06	366	29	7	MP:0001312
MousePheno	fused cornea and lens	AGAP7P AGAP4 AGAP6	1.58e-05	24	29	3	MP:0001307
Domain	ArfGap	AGAP7P AGAP4 AGAP6 AGAP3	3.34e-07	29	38	4	SM00105
Domain	ARFGAP	AGAP7P AGAP4 AGAP6 AGAP3	3.34e-07	29	38	4	PS50115
Domain	ArfGAP	AGAP7P AGAP4 AGAP6 AGAP3	3.34e-07	29	38	4	IPR001164
Domain	ArfGap	AGAP7P AGAP4 AGAP6 AGAP3	3.34e-07	29	38	4	PF01412
Domain	PH	AGAP7P AGAP4 AGAP6 PREX2 ARHGEF9 AGAP3	1.91e-05	278	38	6	SM00233
Domain	PH_DOMAIN	AGAP7P AGAP4 AGAP6 PREX2 ARHGEF9 AGAP3	1.95e-05	279	38	6	PS50003
Domain	PH_domain	AGAP7P AGAP4 AGAP6 PREX2 ARHGEF9 AGAP3	1.98e-05	280	38	6	IPR001849
Domain	PH_dom-like	AGAP7P SSRP1 AGAP4 AGAP6 PREX2 ARHGEF9 AGAP3	2.09e-05	426	38	7	IPR011993
Domain	-	PPP1R14A PPP1R14C	2.41e-05	4	38	2	1.10.150.220
Domain	PP1_inhibitor	PPP1R14A PPP1R14C	2.41e-05	4	38	2	IPR008025
Domain	PP1_inhibitor	PPP1R14A PPP1R14C	2.41e-05	4	38	2	PF05361
Domain	PH	AGAP7P AGAP4 PREX2 ARHGEF9 AGAP3	9.57e-05	229	38	5	PF00169
Domain	-	SSRP1 AGAP4 AGAP6 PREX2 ARHGEF9 AGAP3	1.27e-04	391	38	6	2.30.29.30
Domain	ANK	ANKRD35 AGAP7P AGAP4 AGAP6 AGAP3	1.47e-04	251	38	5	SM00248
Domain	ANK_REPEAT	ANKRD35 AGAP7P AGAP4 AGAP6 AGAP3	1.53e-04	253	38	5	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD35 AGAP7P AGAP4 AGAP6 AGAP3	1.56e-04	254	38	5	IPR020683
Domain	ANK_REP_REGION	ANKRD35 AGAP7P AGAP4 AGAP6 AGAP3	1.56e-04	254	38	5	PS50297
Domain	Ankyrin_rpt	ANKRD35 AGAP7P AGAP4 AGAP6 AGAP3	1.80e-04	262	38	5	IPR002110
Domain	Ank_2	ANKRD35 AGAP4 AGAP6 AGAP3	9.27e-04	215	38	4	PF12796
Domain	Ank	ANKRD35 AGAP7P AGAP4 AGAP3	1.15e-03	228	38	4	PF00023
Domain	FHA	KIF13B AFDN	1.47e-03	28	38	2	SM00240
Domain	-	ANKRD35 AGAP4 AGAP6 AGAP3	1.57e-03	248	38	4	1.25.40.20
Domain	FHA_DOMAIN	KIF13B AFDN	1.81e-03	31	38	2	PS50006
Domain	FHA	KIF13B AFDN	1.81e-03	31	38	2	PF00498
Domain	FHA_dom	KIF13B AFDN	2.43e-03	36	38	2	IPR000253
Domain	-	KIF13B AFDN	2.43e-03	36	38	2	2.60.200.20
Domain	-	ZC3H18 ZC3H13	2.99e-03	40	38	2	4.10.1000.10
Domain	ZnF_C3H1	ZC3H18 ZC3H13	4.29e-03	48	38	2	SM00356
Domain	SMAD_FHA_domain	KIF13B AFDN	5.01e-03	52	38	2	IPR008984
Domain	Znf_CCCH	ZC3H18 ZC3H13	6.20e-03	58	38	2	IPR000571
Domain	ZF_C3H1	ZC3H18 ZC3H13	6.20e-03	58	38	2	PS50103
Domain	DH_1	PREX2 ARHGEF9	7.28e-03	63	38	2	PS00741
Domain	RhoGEF	PREX2 ARHGEF9	8.44e-03	68	38	2	SM00325
Domain	DH_2	PREX2 ARHGEF9	8.92e-03	70	38	2	PS50010
Domain	RhoGEF	PREX2 ARHGEF9	8.92e-03	70	38	2	PF00621
Domain	DH-domain	PREX2 ARHGEF9	9.17e-03	71	38	2	IPR000219
Domain	-	PREX2 ARHGEF9	9.17e-03	71	38	2	1.20.900.10
Domain	Filament	IFFO2 IFFO1	9.17e-03	71	38	2	SM01391
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	FIP1L1 CWF19L2 IK NSRP1 DHX8	1.20e-04	283	25	5	M13087
Pathway	REACTOME_MRNA_SPLICING	CWF19L2 IK NSRP1 DHX8	4.91e-04	212	25	4	M14033
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP7P AGAP4 AGAP6 AGAP3	1.69e-10	9	39	4	12640130
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP7P AGAP4 AGAP6 AGAP3	4.43e-10	11	39	4	15381706
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP7P AGAP4 AGAP6	1.56e-07	10	39	3	20664521
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	FIP1L1 ZFR ZC3H18 LARP1B SSRP1 ZNF598 CCDC9 ZC3H13 DHX8	2.12e-07	807	39	9	22681889
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FIP1L1 MSH6 CWF19L2 ZC3H18 SSRP1 IK NSRP1 CECR2 ZC3H13 DHX8	2.28e-07	1082	39	10	38697112
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	FIP1L1 ZFR IK NSRP1 DHX8	3.51e-07	130	39	5	35545047
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	FIP1L1 ZFR ZC3H18 SSRP1 IK ZC3H13	3.56e-07	251	39	6	31076518
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP7P AGAP4 AGAP6	3.70e-07	13	39	3	27713690
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP7P AGAP4 AGAP6	4.70e-07	14	39	3	22453919
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	MSH6 ZFR ZC3H18 SSRP1 IK DHX8	7.17e-07	283	39	6	30585729
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	FIP1L1 AFDN CWF19L2 ZFR ZC3H18 SSRP1 IK NSRP1 ZC3H13	8.56e-07	954	39	9	36373674
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	FIP1L1 MSH6 ZFR ZC3H18 LARP1B IK ZC3H13 DHX8	1.05e-06	713	39	8	29802200
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B FIP1L1 AFDN LARP1B SSRP1 ZNF598 ESYT1 AGAP3	4.26e-06	861	39	8	36931259
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CRACD MSH6 AFDN SSRP1 IK ZNF598 ESYT1 DHX8 ARHGEF9 AGAP3	4.29e-06	1497	39	10	31527615
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	FIP1L1 MSH6 ZFR ZC3H18 SSRP1 IK ZC3H13	4.42e-06	605	39	7	28977666
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MSH6 AFDN ZFR ZC3H18 IK ZC3H13 DHX8	7.27e-06	653	39	7	22586326
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	MSH6 ZFR ZC3H18 SSRP1 IK ZNF598 ESYT1 ZC3H13 DHX8	8.14e-06	1257	39	9	36526897
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	FIP1L1 CRACD ZFR ZC3H18 SSRP1 IK ZC3H13	1.51e-05	731	39	7	29298432
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	FAM156A FIP1L1 CRACD CLCN3 CCDC9 NSRP1 ZC3H13	1.78e-05	750	39	7	11230166
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	FIP1L1 MSH6 AFDN NSRP1 ZC3H13 AGAP3	1.93e-05	503	39	6	16964243
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FIP1L1 MSH6 AFDN ZC3H18 SSRP1 CCDC9 ZC3H13	2.18e-05	774	39	7	15302935
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	FIP1L1 MSH6 ZC3H18 TCHH SSRP1 NSRP1 CECR2 AGAP3	2.78e-05	1116	39	8	31753913
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MSH6 AFDN ZFR SSRP1 IK ZNF598	3.16e-05	549	39	6	38280479
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FIP1L1 ZFR IK ZNF598 CCDC9 ZC3H13	3.22e-05	551	39	6	34728620
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	FIP1L1 MSH6 SSRP1 ZC3H13	3.37e-05	163	39	4	22113938
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	FIP1L1 ZFR ZC3H18 SSRP1 IK ZC3H13 DHX8	3.86e-05	847	39	7	35850772
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	KIF13B MSH6 SSRP1 ESYT1	4.85e-05	179	39	4	36261009
Pubmed	Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.	FIP1L1 ZFR	6.70e-05	11	39	2	14729963
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	FIP1L1 MSH6 ZFR SSRP1 IK CCDC9	8.24e-05	653	39	6	33742100
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	AGAP7P AGAP4 AGAP6 FN3K AGAP3	8.68e-05	405	39	5	38187761
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FIP1L1 MSH6 ZFR SSRP1 IK NSRP1 ESYT1	1.02e-04	989	39	7	36424410
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	AGAP7P ZNF598 AGAP4 AGAP6	1.04e-04	218	39	4	33378226
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	AGAP7P AGAP4 AGAP6 FN3K AGAP3	1.15e-04	430	39	5	32581705
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	AGAP7P CLCN3 AGAP4 AGAP3	1.17e-04	225	39	4	25277244
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	FIP1L1 CWF19L2 IK CCDC9 NSRP1 ZC3H13	1.22e-04	701	39	6	30196744
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	KIF13B MSH6 ZFR SSRP1 IK DHX8	1.24e-04	704	39	6	29955894
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	FIP1L1 MSH6 ZFR SSRP1 IK	1.29e-04	441	39	5	31239290
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	ZFR LARP1B SSRP1 IK NSRP1 DHX8	1.34e-04	714	39	6	28302793
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	FIP1L1 AFDN ZFR	1.38e-04	89	39	3	22446626
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	KIF13B FIP1L1 LARP1B SSRP1 CCDC9 DHX8	1.44e-04	723	39	6	34133714
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FIP1L1 ZFR LARP1B IK ZNF598 DHX8	1.45e-04	724	39	6	36232890
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MSH6 AFDN ZFR SSRP1 IK DNAH10 ESYT1 DHX8	1.54e-04	1425	39	8	30948266
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	MSH6 ZFR ZC3H18 IK	1.60e-04	244	39	4	29884807
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	FIP1L1 SSRP1 IK HLF	2.01e-04	259	39	4	30404004
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	IFFO2 FIP1L1 AFDN ZFR ESYT1 AGAP3	2.12e-04	777	39	6	35844135
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZC3H18 SSRP1 DHX8	2.13e-04	103	39	3	32744500
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	MSH6 ZFR ZC3H18 NSRP1 ESYT1	2.23e-04	496	39	5	31343991
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	FIP1L1 CRACD ZC3H18 LARP1B ESYT1	2.38e-04	503	39	5	36217030
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	MSH6 CWF19L2 ZFR SSRP1	2.39e-04	271	39	4	32433965
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	CRACD MSH6 ZFR IK NSRP1	2.45e-04	506	39	5	30890647
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	FIP1L1 ZFR LARP1B IK	2.50e-04	274	39	4	34244482
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	MSH6 ZC3H18 SSRP1	3.03e-04	116	39	3	21549307
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	CRACD AGAP4 AGAP6	3.03e-04	116	39	3	30652415
Pubmed	The functional interactome landscape of the human histone deacetylase family.	FIP1L1 MSH6 ZFR IK	3.05e-04	289	39	4	23752268
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MSH6 AFDN IK ESYT1 DHX8	3.89e-04	560	39	5	35241646
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ANKRD35 FIP1L1 SSRP1 IK ZNF598 CCDC9 DHX8	4.21e-04	1247	39	7	27684187
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	FIP1L1 ZFR NSRP1 PREX2 ARHGEF9 AGAP3	5.10e-04	916	39	6	32203420
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	FIP1L1 ZFR ZC3H18 SSRP1 IK ZC3H13 DHX8	5.26e-04	1294	39	7	30804502
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CRACD MSH6 ZFR ZNF598 NSRP1 ESYT1	5.65e-04	934	39	6	33916271
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	FIP1L1 ZFR SSRP1 IK NSRP1 DHX8	6.14e-04	949	39	6	36574265
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	FIP1L1 ZFR ZC3H18	6.17e-04	148	39	3	32538781
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	MSH6 CWF19L2 SSRP1	6.29e-04	149	39	3	25184681
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FIP1L1 MSH6 AFDN ZFR SSRP1 IK ESYT1	6.85e-04	1353	39	7	29467282
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ANKRD35 FIP1L1 ZC3H18 ZC3H13	7.05e-04	361	39	4	26167880
Pubmed	Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.	SSRP1 CCDC9	7.12e-04	35	39	2	30942445
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	FIP1L1 MSH6 ZFR ZC3H18 SSRP1 IK	8.67e-04	1014	39	6	32416067
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FIP1L1 AFDN ZFR SSRP1 IK DHX8	9.13e-04	1024	39	6	24711643
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	CRACD TCHH LARP1B	9.21e-04	170	39	3	23314748
Interaction	DDX23 interactions	FIP1L1 MSH6 CWF19L2 ZC3H18 SSRP1 IK NSRP1 ZC3H13 DHX8	2.57e-07	480	39	9	int:DDX23
Interaction	PABPC5 interactions	CWF19L2 ZFR ZC3H18 LARP1B CCDC9 ZC3H13	2.97e-07	142	39	6	int:PABPC5
Interaction	ZNF830 interactions	ZC3H18 SSRP1 IK ZNF598 DHX8	3.48e-07	76	39	5	int:ZNF830
Interaction	DHX40 interactions	FIP1L1 CWF19L2 ZC3H18 IK NSRP1 ZC3H13 DHX8	4.44e-07	249	39	7	int:DHX40
Interaction	DHX8 interactions	FIP1L1 CWF19L2 ZC3H18 IK NSRP1 ZC3H13 DHX8	1.29e-06	292	39	7	int:DHX8
Interaction	PRP4K interactions	FIP1L1 MSH6 ZC3H18 SSRP1 IK NSRP1 DHX8	2.85e-06	329	39	7	int:PRP4K
Interaction	PAIP1 interactions	ZFR ZC3H18 LARP1B CCDC9 NSRP1	8.80e-06	146	39	5	int:PAIP1
Interaction	SNRNP70 interactions	FIP1L1 MSH6 ZFR ZC3H18 LARP1B SSRP1 IK CCDC9 ZC3H13 DHX8	1.28e-05	984	39	10	int:SNRNP70
Interaction	SNIP1 interactions	FIP1L1 ZC3H18 SSRP1 IK CCDC9 NSRP1 DHX8	1.34e-05	417	39	7	int:SNIP1
Interaction	RNPS1 interactions	FIP1L1 ZFR ZC3H18 SSRP1 IK CCDC9 DHX8	1.52e-05	425	39	7	int:RNPS1
Interaction	SNRPC interactions	FIP1L1 ZFR ZC3H18 SSRP1 IK NSRP1 DHX8	1.90e-05	440	39	7	int:SNRPC
Interaction	PRPF40A interactions	FIP1L1 ZC3H18 SSRP1 ZNF598 CCDC9 NSRP1 DHX8	2.07e-05	446	39	7	int:PRPF40A
Interaction	SAP18 interactions	ZC3H18 SSRP1 IK CCDC9 ZC3H13 DHX8	2.45e-05	305	39	6	int:SAP18
Interaction	CUL7 interactions	FIP1L1 MSH6 AFDN ZFR ZC3H18 SSRP1 IK NSRP1 CECR2	2.62e-05	845	39	9	int:CUL7
Interaction	ELAVL2 interactions	CWF19L2 ZFR ZC3H18 LARP1B CCDC9	2.98e-05	188	39	5	int:ELAVL2
Interaction	SNRPA interactions	FIP1L1 ZFR ZC3H18 SSRP1 IK NSRP1 DHX8	3.40e-05	482	39	7	int:SNRPA
Interaction	TOP1 interactions	FIP1L1 MSH6 ZFR ZC3H18 SSRP1 IK NSRP1 DHX8	4.63e-05	696	39	8	int:TOP1
Interaction	THOC1 interactions	ZC3H18 SSRP1 IK ZC3H13 DHX8	5.05e-05	210	39	5	int:THOC1
Interaction	TSSC4 interactions	CWF19L2 ZC3H18 IK DHX8	6.18e-05	111	39	4	int:TSSC4
Interaction	CLK3 interactions	ZFR ZC3H18 LARP1B CCDC9 ZC3H13	6.30e-05	220	39	5	int:CLK3
Interaction	SMC5 interactions	FIP1L1 AFDN CWF19L2 ZFR ZC3H18 SSRP1 IK NSRP1 ZC3H13	9.69e-05	1000	39	9	int:SMC5
Interaction	MEN1 interactions	KIF13B FIP1L1 AFDN ZFR ZC3H18 SSRP1 IK ZC3H13 DHX8	1.20e-04	1029	39	9	int:MEN1
Interaction	MECP2 interactions	FIP1L1 MSH6 CWF19L2 ZC3H18 SSRP1 IK NSRP1 CECR2 ZC3H13 DHX8	1.26e-04	1287	39	10	int:MECP2
Interaction	ISY1 interactions	CWF19L2 ZC3H18 SSRP1 DHX8	1.32e-04	135	39	4	int:ISY1
Interaction	SRSF7 interactions	ZFR ZC3H18 LARP1B IK CCDC9 DHX8	1.54e-04	425	39	6	int:SRSF7
Interaction	TFIP11 interactions	FAM156A CWF19L2 ZC3H18 IK DHX8 ARHGEF9	1.58e-04	427	39	6	int:TFIP11
Interaction	BCAS2 interactions	CWF19L2 ZC3H18 SSRP1 IK DHX8	1.65e-04	270	39	5	int:BCAS2
Interaction	HNRNPC interactions	CWF19L2 ZFR ZC3H18 LARP1B SSRP1 CCDC9 DHX8	1.89e-04	634	39	7	int:HNRNPC
Interaction	PPIE interactions	CWF19L2 ZC3H18 SSRP1 IK DHX8	2.02e-04	282	39	5	int:PPIE
Interaction	TBC1D25 interactions	KIF13B AFDN LARP1B	2.12e-04	60	39	3	int:TBC1D25
Interaction	RPA4 interactions	AFDN ZC3H18 SSRP1 IK ESYT1 AGAP3	2.14e-04	452	39	6	int:RPA4
Interaction	RAD18 interactions	FIP1L1 ZFR ZC3H18 SSRP1 IK ZC3H13	2.28e-04	457	39	6	int:RAD18
Interaction	ZC3H18 interactions	FIP1L1 CRACD ZFR ZC3H18 SSRP1 IK ZC3H13 DHX8	2.30e-04	877	39	8	int:ZC3H18
Interaction	HNRNPUL2 interactions	CWF19L2 ZFR ZC3H18 LARP1B SSRP1	2.34e-04	291	39	5	int:HNRNPUL2
Interaction	ZC3H13 interactions	ZC3H18 SSRP1 ZC3H13 DHX8	2.42e-04	158	39	4	int:ZC3H13
Interaction	MFAP1 interactions	FIP1L1 ZC3H18 IK NSRP1 DHX8	2.49e-04	295	39	5	int:MFAP1
Interaction	PRPF38A interactions	FIP1L1 ZC3H18 NSRP1 DHX8	2.60e-04	161	39	4	int:PRPF38A
Interaction	IFI27L1 interactions	IK NSRP1 ZC3H13	2.69e-04	65	39	3	int:IFI27L1
Interaction	ZC3H14 interactions	ZC3H18 SSRP1 CCDC9 DHX8	3.12e-04	169	39	4	int:ZC3H14
Interaction	SART1 interactions	FIP1L1 ZC3H18 SSRP1 NSRP1 DHX8	3.46e-04	317	39	5	int:SART1
Interaction	SYF2 interactions	CWF19L2 ZC3H18 DHX8	3.50e-04	71	39	3	int:SYF2
Interaction	CHD4 interactions	FIP1L1 MSH6 ZFR ZC3H18 SSRP1 IK ZNF598 DHX8	3.63e-04	938	39	8	int:CHD4
Interaction	HSPB1 interactions	ANKRD35 MSH6 ZC3H18 AGAP7P CLCN3 AGAP4 AGAP3	3.70e-04	708	39	7	int:HSPB1
Interaction	RBM25 interactions	FIP1L1 MSH6 ZC3H18 NSRP1 DHX8	3.77e-04	323	39	5	int:RBM25
Interaction	SRSF6 interactions	ZFR ZC3H18 LARP1B SSRP1 ZC3H13 DHX8	3.80e-04	503	39	6	int:SRSF6
Interaction	HNRNPA1 interactions	FIP1L1 AFDN ZFR ZC3H18 LARP1B SSRP1 NSRP1 ZC3H13	3.82e-04	945	39	8	int:HNRNPA1
Interaction	AAMP interactions	CWF19L2 SSRP1 CCDC9	4.11e-04	75	39	3	int:AAMP
Interaction	TRA2A interactions	ZFR ZC3H18 LARP1B SSRP1 IK	4.16e-04	330	39	5	int:TRA2A
Interaction	ZFC3H1 interactions	ZC3H18 LARP1B SSRP1 DHX8	4.40e-04	185	39	4	int:ZFC3H1
Interaction	CDX1 interactions	ZFR LARP1B DHX8	4.97e-04	80	39	3	int:CDX1
Interaction	SIRT7 interactions	MSH6 AFDN ZFR ZC3H18 IK ZC3H13 DHX8	4.98e-04	744	39	7	int:SIRT7
Interaction	PABPN1 interactions	ZC3H18 SSRP1 CCDC9 NSRP1	5.06e-04	192	39	4	int:PABPN1
Interaction	SNW1 interactions	FIP1L1 MSH6 CWF19L2 ZC3H18 SSRP1 IK DHX8	5.10e-04	747	39	7	int:SNW1
Interaction	CHD3 interactions	FIP1L1 MSH6 ZFR ZC3H18 SSRP1 IK ZC3H13	5.52e-04	757	39	7	int:CHD3
Interaction	NSRP1 interactions	FIP1L1 NSRP1 DHX8 ARHGEF9	5.57e-04	197	39	4	int:NSRP1
Interaction	LUC7L2 interactions	ZC3H18 LARP1B IK CCDC9 DHX8	5.66e-04	353	39	5	int:LUC7L2
Interaction	COIL interactions	MSH6 CWF19L2 ZC3H18 SSRP1 IK DHX8	6.21e-04	552	39	6	int:COIL
Interaction	TERF2IP interactions	CWF19L2 ZC3H18 SSRP1 IK NSRP1 DHX8	6.21e-04	552	39	6	int:TERF2IP
Interaction	DDX42 interactions	FIP1L1 SSRP1 NSRP1 DHX8	6.83e-04	208	39	4	int:DDX42
Interaction	NUDT21 interactions	FIP1L1 ZC3H18 NSRP1 ESYT1 DHX8	6.91e-04	369	39	5	int:NUDT21
Interaction	EZH1 interactions	IK NSRP1 ZC3H13	7.47e-04	92	39	3	int:EZH1
Interaction	LIN28B interactions	CWF19L2 ZFR ZC3H18 LARP1B	7.60e-04	214	39	4	int:LIN28B
Interaction	ZC3H11A interactions	ZC3H18 SSRP1 CCDC9 DHX8	7.73e-04	215	39	4	int:ZC3H11A
Interaction	PLRG1 interactions	CWF19L2 ZC3H18 SSRP1 DHX8	7.87e-04	216	39	4	int:PLRG1
Interaction	DOT1L interactions	FIP1L1 ZFR ZC3H18 SSRP1 IK ZC3H13 DHX8	8.07e-04	807	39	7	int:DOT1L
Interaction	LINC02910 interactions	KIF13B NSRP1 ZC3H13	8.20e-04	95	39	3	int:LINC02910
Interaction	PURG interactions	ZFR ZC3H18 LARP1B DHX8	8.86e-04	223	39	4	int:PURG
Interaction	SYMPK interactions	FIP1L1 SSRP1 ZNF598 DHX8	9.16e-04	225	39	4	int:SYMPK
Interaction	FIP1L1 interactions	FIP1L1 ZC3H18 NSRP1 DHX8	9.16e-04	225	39	4	int:FIP1L1
Interaction	AKAP17A interactions	ZC3H18 CCDC9 DHX8	9.24e-04	99	39	3	int:AKAP17A
Interaction	CCDC12 interactions	CWF19L2 ZC3H18 DHX8	1.07e-03	104	39	3	int:CCDC12
Interaction	SUPT5H interactions	MSH6 CWF19L2 ZC3H18 SSRP1 IK	1.08e-03	408	39	5	int:SUPT5H
Cytoband	10q11.23	AGAP7P AGAP6	3.65e-04	33	39	2	10q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	AGAP7P AGAP4 AGAP6	5.54e-04	188	39	3	chr10q11
Cytoband	4q12	FIP1L1 CRACD	1.01e-03	55	39	2	4q12
Cytoband	Ensembl 112 genes in cytogenetic band chr4q12	FIP1L1 CRACD	2.35e-03	84	39	2	chr4q12
GeneFamily	ArfGAPs	AGAP7P AGAP4 AGAP6 AGAP3	1.57e-07	33	27	4	395
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6 AGAP3	1.99e-06	17	27	3	1291
GeneFamily	Intermediate filament family orphans	IFFO2 IFFO1	2.15e-06	2	27	2	614
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP7P AGAP4 AGAP6 ARHGEF9 AGAP3	1.20e-05	206	27	5	682
GeneFamily	Ankyrin repeat domain containing	ANKRD35 AGAP7P AGAP4 AGAP6 AGAP3	2.62e-05	242	27	5	403
GeneFamily	Zinc fingers CCCH-type	ZC3H18 ZC3H13	1.24e-03	35	27	2	73
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R14A PPP1R14C PREX2	2.42e-03	181	27	3	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PREX2 ARHGEF9	4.34e-03	66	27	2	722
GeneFamily	PDZ domain containing	AFDN PREX2	2.15e-02	152	27	2	1220
Coexpression	THEODOROU_MAMMARY_TUMORIGENESIS	AGAP7P AGAP4 AGAP6	2.28e-05	37	39	3	MM1121
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN	AGAP7P AGAP4 AGAP6	3.87e-05	44	39	3	MM485
Disease	cerebral palsy (implicated_via_orthology)	AGAP7P AGAP4 AGAP6	2.35e-07	10	38	3	DOID:1969 (implicated_via_orthology)
Disease	breast carcinoma (is_marker_for)	MSH6 AFDN	3.29e-03	66	38	2	DOID:3459 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRWYEKEKARLEEER	AFDN	1416	P55196
TREEKERWIRSKYEE	AGAP4	536	Q96P64
CREEKERWIRAKYEQ	AGAP3	721	Q96P47
ALYLGWRRVRDEKER	ESYT1	86	Q9BSJ8
EEWRWKYEEERRKVV	ANKRD35	296	Q8N283
WIREDEKREKRRSRA	CECR2	551	Q9BXF3
RDLEDRLARYQRKWD	CFAP157	46	Q5JU67
TREEKERWIRSKYEE	AGAP6	536	Q5VW22
EEKIRWLRAFREERK	ARHGEF9	411	O43307
RERSDRVWKREKDRE	NSRP1	371	Q9H0G5
RVWKREKDREKYSQR	NSRP1	376	Q9H0G5
RYREEKTLEERRWER	FAM156A	66	Q8NDB6
ASTKEDYRRERWRKP	CWF19L2	276	Q2TBE0
WDYYARREKDRDRER	FIP1L1	451	Q6UN15
DDLKDDKYWARRRKN	HLF	221	Q16534
EWLKEEKRRDEHRRR	MSH6	371	P52701
AKVKRERDEYKRRWE	IFFO1	246	Q0D2I5
YDRRELQRRLDVEKW	PPP1R14A	41	Q96A00
RSEYLRWKQEREKID	CCDC9	261	Q9Y3X0
RRRQEDYWRELEAKC	CRACD	221	Q6ZU35
TREEKERWIRSKYEE	AGAP7P	536	Q5VUJ5
KVKRERDEYKRRWEE	IFFO2	211	Q5TF58
RDEYKRRWEEELAKR	IFFO2	216	Q5TF58
DRKYLKDWAREEFRR	LYRM2	41	Q9NU23
DRWEFDRKRLFERTD	DNAH10	451	Q8IVF4
DYRMKEWSRREAERL	NDUFB11	111	Q9NX14
KDRDKYGERNLDRWR	DHX8	236	Q14562
NDTRSWKRDREKRDD	LARP1B	116	Q659C4
YDRKELRKRLVLEEW	PPP1R14C	76	Q8TAE6
DSYQDRDLERLRRKW	KIF13B	1081	Q9NQT8
EKDYADREARELWSR	FN3K	181	Q9H479
WDRKAEDARRDYEKA	SSRP1	596	Q08945
IDWVREKCKDRERHR	CLCN3	91	P51790
DEKRRWTLDLESRYD	ZFP30	71	Q9Y2G7
EWFEAILKERERRKG	PREX2	351	Q70Z35
RERELAEKYRDRAKE	IK	91	Q13123
RGSWRYKREEEDREV	ZNF598	331	Q86UK7
QKEEYWRRREEEERW	ZFR	641	Q96KR1
EEREKRRRQEWERQY	TCHH	1006	Q07283
RRRQEWERQYRKKDE	TCHH	1011	Q07283
RQRDWEDKDKGRDDR	ZC3H13	786	Q5T200
ERDKERQRRKEEWER	ZC3H18	441	Q86VM9