Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal brain wave pattern	HIVEP2 PCDH19 BSN NOS1	2.91e-05	64	39	4	MP:0004994
Domain	CNH	TNIK MINK1 MAP4K4	6.84e-06	14	51	3	SM00036
Domain	CNH	TNIK MINK1 MAP4K4	8.53e-06	15	51	3	PF00780
Domain	CNH	TNIK MINK1 MAP4K4	8.53e-06	15	51	3	PS50219
Domain	CNH_dom	TNIK MINK1 MAP4K4	8.53e-06	15	51	3	IPR001180
Domain	Cul7	CUL9 HERC2	2.19e-05	3	51	2	PF11515
Domain	CPH_domain	CUL9 HERC2	2.19e-05	3	51	2	IPR021097
Domain	APC_su10/DOC_dom	CUL9 HERC2	1.52e-04	7	51	2	IPR004939
Domain	DOC	CUL9 HERC2	1.52e-04	7	51	2	PS51284
Domain	APC10	CUL9 HERC2	1.52e-04	7	51	2	SM01337
Domain	ANAPC10	CUL9 HERC2	1.52e-04	7	51	2	PF03256
Domain	DHC_N1	DNAH5 DNAH8	2.03e-04	8	51	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH5 DNAH8	2.03e-04	8	51	2	IPR013594
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH8	6.51e-04	14	51	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH8	6.51e-04	14	51	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH8	6.51e-04	14	51	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH8	6.51e-04	14	51	2	PF08393
Domain	MT	DNAH5 DNAH8	6.51e-04	14	51	2	PF12777
Domain	AAA_8	DNAH5 DNAH8	6.51e-04	14	51	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH8	6.51e-04	14	51	2	IPR011704
Domain	AAA_5	DNAH5 DNAH8	6.51e-04	14	51	2	PF07728
Domain	DHC_fam	DNAH5 DNAH8	7.50e-04	15	51	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH8	7.50e-04	15	51	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH8	7.50e-04	15	51	2	PF03028
Domain	C345C	SFRP4 ADAMTSL5	9.68e-04	17	51	2	SM00643
Domain	Rib_L2_dom2	CUL9 HERC2	1.09e-03	18	51	2	IPR014722
Domain	-	CUL9 HERC2	1.09e-03	18	51	2	2.30.30.30
Domain	NTR	SFRP4 ADAMTSL5	1.21e-03	19	51	2	PF01759
Domain	Netrin_module_non-TIMP	SFRP4 ADAMTSL5	1.21e-03	19	51	2	IPR018933
Domain	NTR	SFRP4 ADAMTSL5	1.78e-03	23	51	2	PS50189
Domain	Netrin_domain	SFRP4 ADAMTSL5	1.78e-03	23	51	2	IPR001134
Domain	TIMP-like_OB-fold	SFRP4 ADAMTSL5	2.28e-03	26	51	2	IPR008993
Domain	AAA+_ATPase	ATAD2B DNAH5 DNAH8	7.13e-03	144	51	3	IPR003593
Domain	AAA	ATAD2B DNAH5 DNAH8	7.13e-03	144	51	3	SM00382
Pathway	WP_HIPPOYAP_SIGNALING	TNIK MINK1 MAP4K4	3.14e-05	22	40	3	M39821
Pathway	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE	TNIK MINK1 MAP4K4	1.54e-04	37	40	3	MM14899
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	HERC2 BSN CDKAL1 STAT3	1.11e-07	28	55	4	19422935
Pubmed	Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.	THADA BACH2 BSN CDKAL1 STAT3	1.15e-06	116	55	5	21102463
Pubmed	Rap2A links intestinal cell polarity to brush border formation.	TNIK MINK1 MAP4K4	1.68e-06	15	55	3	22797597
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	HERC2 CDKAL1 STAT3	2.07e-06	16	55	3	19068216
Pubmed	Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway.	MVP STAT3	2.46e-06	2	55	2	31092229
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DOCK3 TARS3 HIVEP2 B4GAT1 SLF2 CUL9 UBA3 HERC2 MAP4K4 MVP STAT3	4.51e-06	1285	55	11	35914814
Pubmed	Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.	HERC2 CDKAL1 STAT3	6.48e-06	23	55	3	20886065
Pubmed	Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation.	GAB4 STAT3	7.36e-06	3	55	2	19581930
Pubmed	MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1.	TNIK MINK1	7.36e-06	3	55	2	18930710
Pubmed	Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.	SLF2 ATAD2B	1.47e-05	4	55	2	24561620
Pubmed	A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection.	GAB4 STAT3	1.47e-05	4	55	2	17353274
Pubmed	Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.	THADA BACH2 CDKAL1	1.97e-05	33	55	3	20203524
Pubmed	Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.	HERC2 STAT3	2.45e-05	5	55	2	18438405
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	TNIK AGO2 BSN NYAP1 MAP4K4	2.49e-05	218	55	5	33378226
Pubmed	Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells.	AGO2 STAT3	3.67e-05	6	55	2	31507089
Pubmed	Digital quantification of human eye color highlights genetic association of three new loci.	HERC2 LYST	3.67e-05	6	55	2	20463881
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH5 DNAH8	5.13e-05	7	55	2	9256245
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH5 DNAH8	5.13e-05	7	55	2	31178125
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 THADA HIVEP2 ADAMTSL5 BCAS3 CUL9 HERC2 MLXIP LYST	5.46e-05	1105	55	9	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HIVEP2 SLF2 BCAS3 MINK1 MLXIP MAP4K4 LYST STAT3	5.94e-05	861	55	8	36931259
Pubmed	The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.	MINK1 MAP4K4	1.60e-04	12	55	2	35027733
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	THADA BACH2 BSN CDKAL1 STAT3	2.08e-04	342	55	5	23128233
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	SFRP4 LYST	2.21e-04	14	55	2	11472062
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH5 DNAH8	2.21e-04	14	55	2	9373155
Pubmed	Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.	THADA CDKAL1	3.29e-04	17	55	2	19741467
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	PCDH19 NOS1	3.29e-04	17	55	2	27779093
Pubmed	Association analysis of 3p21 with Crohn's disease in a New Zealand population.	DOCK3 BSN	3.29e-04	17	55	2	20307617
Pubmed	Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.	THADA CDKAL1	3.29e-04	17	55	2	19502414
Pubmed	The Transcription Factors EBF1 and EBF2 Are Positive Regulators of Myelination in Schwann Cells.	SFRP4 PCDH19	3.29e-04	17	55	2	27889898
Pubmed	Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.	THADA CDKAL1	3.70e-04	18	55	2	19324937
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TNIK AGO2 BACH2 HERC2 MLXIP MAP4K4 STAT3	3.80e-04	853	55	7	28718761
Pubmed	MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.	TNIK MINK1 MAP4K4 MVP	3.85e-04	216	55	4	32640226
Pubmed	Clinical risk factors, DNA variants, and the development of type 2 diabetes.	THADA CDKAL1	4.13e-04	19	55	2	19020324
Pubmed	Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.	BACH2 HERC2	4.13e-04	19	55	2	22561518
Pubmed	Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.	THADA CDKAL1	4.13e-04	19	55	2	19139842
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	DOCK3 SLF2 HERC2	4.25e-04	92	55	3	15840729
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	TNIK MINK1 BSN MAP4K4 MVP NOS1	4.36e-04	621	55	6	22794259
Pubmed	Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.	THADA CDKAL1	4.58e-04	20	55	2	20075150
Pubmed	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.	THADA CDKAL1	4.58e-04	20	55	2	19862325
Pubmed	Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.	THADA CDKAL1	4.58e-04	20	55	2	19933996
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNIK PCDH19 CUL9 MLXIP MAP3K4	4.61e-04	407	55	5	12693553
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	CUL9 UBA3 HERC2	4.67e-04	95	55	3	29643511
Pubmed	Genotype score in addition to common risk factors for prediction of type 2 diabetes.	THADA CDKAL1	5.06e-04	21	55	2	19020323
Pubmed	Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.	THADA CDKAL1	5.06e-04	21	55	2	18591388
Pubmed	Underlying genetic models of inheritance in established type 2 diabetes associations.	THADA CDKAL1	5.06e-04	21	55	2	19602701
Pubmed	Identification of cellular proteins required for replication of human immunodeficiency virus type 1.	UBA3 SLC51A	5.06e-04	21	55	2	22404213
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	TNIK PCDH19 MINK1 MAP4K4 CDKAL1	5.37e-04	421	55	5	36976175
Pubmed	Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.	THADA CDKAL1	5.56e-04	22	55	2	19794065
Pubmed	Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.	HERC2 CDKAL1	5.56e-04	22	55	2	19174780
Pubmed	Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.	THADA CDKAL1	5.56e-04	22	55	2	18372903
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	DOCK3 ZNF469 USF3 BSN NYAP1	5.91e-04	430	55	5	35044719
Pubmed	Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study.	THADA CDKAL1	6.08e-04	23	55	2	19720844
Pubmed	Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.	THADA CDKAL1	7.20e-04	25	55	2	20879858
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TNIK AGO2 MINK1 HERC2 BSN MAP4K4 NOS1	7.79e-04	963	55	7	28671696
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	THADA CDKAL1	8.40e-04	27	55	2	20490451
Pubmed	Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.	CDKAL1 STAT3	9.04e-04	28	55	2	18587394
Pubmed	Obesity and diabetes genetic variants associated with gestational weight gain.	THADA CDKAL1	9.70e-04	29	55	2	20816152
Pubmed	Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.	THADA STAT3	9.70e-04	29	55	2	22190364
Pubmed	A human MAP kinase interactome.	USF3 HIVEP2 HERC2 MAP4K4 MAP3K4	1.02e-03	486	55	5	20936779
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	TNIK MINK1 MAP4K4	1.09e-03	127	55	3	30442766
Pubmed	Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.	CDKAL1 STAT3	1.11e-03	31	55	2	21072187
Pubmed	Primary Ciliary Dyskinesia	DNAH5 DNAH8	1.18e-03	32	55	2	20301301
Pubmed	Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.	SFRP4 PCDH19	1.33e-03	34	55	2	32553152
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TNIK CUL9 HERC2 MAP4K4	1.53e-03	313	55	4	38270169
Interaction	DSCAM interactions	TARS3 AGO2 CUL9 UBA3 MAP4K4 STAT3	5.04e-06	171	52	6	int:DSCAM
GeneFamily	Dyneins, axonemal	DNAH5 DNAH8	6.36e-04	17	40	2	536
ToppCell	Control-Neu_0\|World / 5 Neutrophil clusters in COVID-19 patients	USF3 FAM157B FAM157A TMEM164	1.48e-05	120	55	4	840d0ac995e2fa41996514753e4e03c4aa4a26d0
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FAM157C FAM157B FAM157A TMEM164	1.90e-05	128	55	4	9b3c57d559a5ed8d590dd89b64a57a3227d8c684
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FAM157C FAM157B FAM157A TMEM164	1.90e-05	128	55	4	58639cfdc70ff6764adcc5c1ce9eba9d033b8209
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 TTLL3 CRTAM CDKAL1	4.67e-05	161	55	4	334f540dff3508d451e5e85e8e4e8f3b8d6b74e7
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 TTLL3 CRTAM CDKAL1	4.67e-05	161	55	4	81d44438e4be4e68a59247e62f02026301a8a0c5
ToppCell	343B-Lymphocytic-ILC\|343B / Donor, Lineage, Cell class and subclass (all cells)	USF3 TTLL3 UBA3 CSKMT	5.26e-05	166	55	4	a54377c703efff42d2cc1a8fdb610facc58053dd
ToppCell	Mild/Remission-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TCP11L2 BACH2 ATAD2B LYST	6.18e-05	173	55	4	694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNIK CRTAM PNPLA3 LYST	7.21e-05	180	55	4	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNIK CRTAM PNPLA3 LYST	7.21e-05	180	55	4	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNIK CRTAM PNPLA3 LYST	7.21e-05	180	55	4	466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK DOCK3 BACH2 MVP	7.85e-05	184	55	4	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	Control-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TNIK THADA CDKAL1 STAT3	8.01e-05	185	55	4	e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGO2 MLXIP MAP4K4 STAT3	8.01e-05	185	55	4	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	AGO2 HIVEP2 BACH2 STAT3	8.52e-05	188	55	4	939790f133eac9c12d08db6ddb5f08f5107844e3
ToppCell	IPF-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TNIK THADA CUL9 STAT3	8.70e-05	189	55	4	7a260485c2a7c743c14d048e5e480ae0a9b8e32c
ToppCell	343B-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	USF3 TTLL3 UBA3 CSKMT	8.70e-05	189	55	4	c26428871dc3261327d89cacaba6e21e004ff1f3
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TNIK THADA DNAH8 STAT3	9.06e-05	191	55	4	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	AGO2 HIVEP2 MAP4K4 STAT3	9.25e-05	192	55	4	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK BACH2 DNAH5 STAT3	9.82e-05	195	55	4	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK BACH2 DNAH5 STAT3	9.82e-05	195	55	4	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	COVID-19-Lymphoid-Tregs\|Lymphoid / Condition, Lineage and Cell class	TNIK TCP11L2 CUL9 DNAH8	9.82e-05	195	55	4	9ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCP11L2 MAP4K4 MVP STAT3	1.00e-04	196	55	4	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNIK CUL9 DNAH8 STAT3	1.04e-04	198	55	4	03423d6c614440b9c738f75ac3f5a6941719a279
ToppCell	FLU-Healthy-4\|Healthy / Virus stimulation, Condition and Cluster	AGO2 BACH2 CRTAM STAT3	1.06e-04	199	55	4	40061131e35131873192ca65c0e731a7b3045636
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HIVEP2 ADAMTSL5 PCDH19 MINK1	1.08e-04	200	55	4	be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HIVEP2 ADAMTSL5 PCDH19 MINK1	1.08e-04	200	55	4	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
Drug	Trolox [53188-07-1]; Down 200; 16uM; PC3; HT_HG-U133A	HINFP BCAS3 ATAD2B MINK1 CUL9 MVP	5.85e-06	198	52	6	7304_DN
Drug	NIH-3	BSN LYST CRHR2	1.06e-05	19	52	3	CID009822007
Disease	epilepsy (implicated_via_orthology)	TNIK MINK1 BSN MAP4K4 NOS1	1.02e-05	163	52	5	DOID:1826 (implicated_via_orthology)
Disease	latent autoimmune diabetes in adults	THADA BACH2	1.82e-05	4	52	2	EFO_0009706
Disease	body height at birth	HIVEP2 ATAD2B CDKAL1	4.87e-05	40	52	3	EFO_0006784
Disease	Diabetes Mellitus, Sudden-Onset	BACH2 NOS1 STAT3	6.50e-05	44	52	3	C4554117
Disease	Diabetes Mellitus, Ketosis-Prone	BACH2 NOS1 STAT3	6.50e-05	44	52	3	C3837958
Disease	Diabetes, Autoimmune	BACH2 NOS1 STAT3	6.50e-05	44	52	3	C0205734
Disease	Brittle diabetes	BACH2 NOS1 STAT3	6.50e-05	44	52	3	C0342302
Disease	Diabetes Mellitus, Insulin-Dependent	BACH2 NOS1 STAT3	6.95e-05	45	52	3	C0011854
Disease	hair colour measurement	TNIK ZNF469 THADA FAM157C HERC2 LYST CDKAL1	9.79e-05	615	52	7	EFO_0007822
Disease	inflammatory bowel disease	THADA BACH2 BSN MAP4K4 CDKAL1 STAT3	1.35e-04	449	52	6	EFO_0003767
Disease	ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis	THADA BACH2 BSN CDKAL1 STAT3	1.71e-04	295	52	5	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
Disease	Lung diseases	DNAH5 CRHR2 STAT3	3.58e-04	78	52	3	C0024115
Disease	mean reticulocyte volume	ZNF469 THADA AGO2 BACH2 ATAD2B MLXIP CDKAL1	4.82e-04	799	52	7	EFO_0010701
Disease	lymphocyte count	TNIK ZNF469 THADA BCAS3 BACH2 ATAD2B MINK1 DUSP14 LYST	9.48e-04	1464	52	9	EFO_0004587
Disease	treatment-resistant hypertension	DOCK3 BCAS3 GAB4	9.50e-04	109	52	3	EFO_1002006
Disease	myeloperoxidase measurement	THADA BCAS3	9.64e-04	26	52	2	EFO_0005243
Disease	Fever	NOS1 STAT3	1.04e-03	27	52	2	C0015967
Disease	Crohn's disease	THADA BACH2 BSN CDKAL1 STAT3	1.06e-03	441	52	5	EFO_0000384
Disease	Cocaine-Related Disorders	AGO2 DNAH8 CRHR2	1.17e-03	117	52	3	C0236736
Disease	HbA1c measurement	TNIK HINFP THADA ATAD2B BSN CDKAL1	1.17e-03	675	52	6	EFO_0004541
Disease	cutaneous melanoma	BACH2 HERC2 CDKAL1	1.28e-03	121	52	3	EFO_0000389
Disease	puberty onset measurement	DOCK3 SLF2 HERC2	1.41e-03	125	52	3	EFO_0005677
Disease	Cocaine Abuse	AGO2 DNAH8 CRHR2	1.48e-03	127	52	3	C0009171
Disease	Astigmatism	TRIM42 HERC2 DNAH5	1.54e-03	129	52	3	HP_0000483
Disease	interleukin 2 receptor antagonist measurement	ZNF469 ZNRF4	1.75e-03	35	52	2	EFO_0008332

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRPRRPLVFMSLVCA	ARSF	1	P54793
MADHLPGRMRPNTSC	BACH2	486	Q9BYV9
CPDMRARVAMHLVCP	B4GAT1	146	O43505
PRLQTLRMTLPSPHM	BRICD5	61	Q6PL45
HSTLPRTLMAPRMIS	DUSP14	6	O95147
PCVRTHMSPRVVNRM	BCAS3	441	Q9H6U6
MRHLPSMRYTPVGRS	AGO2	166	Q9UKV8
HSDRCWMPRNPMPIR	PCDH19	966	Q8TAB3
PPLCDMHPMRALFLI	MAP4K4	231	O95819
ICHPLKYMTLMSPRV	OR2AG2	126	A6NM03
MRGLMPLAFCVHPLL	P2RY11	306	Q96G91
GLMCRMSNKPHPRPH	LEXM	191	Q3ZCV2
VMAHLDRLATPCMPP	HERC2	396	O95714
SMAPPRRKHAALCAM	ATAD2B	916	Q9ULI0
LSMAHSRVRPPMRSQ	BSN	3486	Q9UPA5
NSTMIRHTCPMSVPL	FAM157A	36	C9JC47
RVLMCLLPASRSQMP	PNPLA3	396	Q9NST1
RMLHLPSLMMGTCRP	CSKMT	6	A8MUP2
TECGRPHREMRMNPK	DNAH8	2146	Q96JB1
RVHRCPPLMDITLHM	INTS2	866	Q9H0H0
HSLRVPMARAMSIPT	CRHR2	381	Q13324
NATMIRHTCPMSVPL	FAM157C	36	P0CG43
PCPMLAPHRDYLMAV	ADAMTSL5	426	Q6ZMM2
APMRMVTVPPRHYCT	MVP	46	Q14764
CMGSIMHPSQHARRP	NOS1	336	P29475
RTLRDTPMMVHTGPC	SLC51A	146	Q86UW1
MAADVFMCSPRRPRS	MLXIP	1	Q9HAP2
YSCTPRMNRRMVGPD	FAM189A2	156	Q15884
NSTMIRHTCPMSVPL	FAM157B	36	P0CG42
MRPRHGETCRMPVPH	DOCK3	201	Q8IZD9
HVVLMCSTMRSKPPP	CRTAM	136	O95727
ASSRMVLPMPRLHQD	CDKAL1	541	Q5VV42
VLPMPRLHQDCALRM	CDKAL1	546	Q5VV42
MHEQMCLRQSSEPPR	GAB4	556	Q2WGN9
MAAHMLRSRSLPAFP	LYST	2096	Q99698
MSLMAICRPLPVTFH	CUTC	131	Q9NTM9
LTPSRMIYCQRMSPP	KLF17	106	Q5JT82
LMHMLCNPEPQIRRS	CUL9	171	Q8IWT3
DMTCPLPSSLRNHMR	HINFP	261	Q9BQA5
TLGRPPHLIMRIMDC	DNAH5	3311	Q8TE73
PPLCDMHPMRALFLI	MINK1	231	Q8N4C8
MTMPASQEHTPHPCR	NYAP1	61	Q6ZVC0
RNSPRPMKVPRCHSD	MAP3K4	1146	Q9Y6R4
CLMFAHRPRSWREMP	TARS3	496	A2RTX5
CPMCSRLRLHSFMLP	TRIM42	146	Q8IWZ5
RPPSPEMLCHLQRMV	THADA	1861	Q6YHU6
MRRLLCLPSPQKCMP	TCP11L2	446	Q8N4U5
MTRRCMPARPGFPSS	SLF2	1	Q8IX21
MCTIASMPRLPEHCI	UBA3	236	Q8TBC4
PPLCDMHPMRALFLI	TNIK	231	Q9UKE5
VTMMHIFLLACPPCR	TMEM164	126	Q5U3C3
FVVERQPCMPMHPDR	STAT3	321	P40763
GAPCEAVRIPMCRHM	SFRP4	21	Q6FHJ7
MPLCRPEHLMPRASR	ZNRF4	1	Q8WWF5
HCQPAPLRLESMSLM	USF3	1346	Q68DE3
PMAMCHRRMGVRPAV	TTLL3	541	Q9Y4R7
ARPSPHGMEMLSRLP	ZNF469	491	Q96JG9
NSMMFGHLSPVRIPR	nan	6	A8MV72
EMRRCSSEQMPCPHP	HIVEP2	1026	P31629
SMMFGHLSPVRNPRL	nan	36	A6NL46