Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.10e-06	5	97	3	GO:0030156
GeneOntologyMolecularFunction	mRNA cap binding complex binding	ZC3H18 SRRT	1.39e-04	4	97	2	GO:0140262
GeneOntologyMolecularFunction	RNA polymerase II C-terminal domain phosphoserine binding	LEO1 SCAF4	2.31e-04	5	97	2	GO:1990269
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE3 SUN2	2.31e-04	5	97	2	GO:0140444
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH10 CCDC88B DYNC1H1	3.33e-04	28	97	3	GO:0051959
GeneOntologyBiologicalProcess	cytoplasm protein quality control by the ubiquitin-proteasome system	UBR4 UBR5	6.02e-05	3	93	2	GO:0071629
GeneOntologyBiologicalProcess	cytoplasm protein quality control	UBR4 UBR5	6.02e-05	3	93	2	GO:0140455
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B DYNC1H1	7.23e-06	28	94	4	GO:0002177
GeneOntologyCellularComponent	nuclear membrane	BRIP1 RGPD8 TEX2 CEP128 SYNE3 SUN2 TOR1B DMPK	1.78e-04	349	94	8	GO:0031965
GeneOntologyCellularComponent	nuclear envelope	BRIP1 RGPD8 TEX2 CEP128 SYNE3 SUN2 TOR1B DMPK DYNC1H1 RGPD5	2.11e-04	560	94	10	GO:0005635
GeneOntologyCellularComponent	microtubule organizing center attachment site	SYNE3 SUN2	1.07e-03	11	94	2	GO:0034992
GeneOntologyCellularComponent	meiotic nuclear membrane microtubule tethering complex	SYNE3 SUN2	1.07e-03	11	94	2	GO:0034993
GeneOntologyCellularComponent	nuclear membrane protein complex	SYNE3 SUN2	1.07e-03	11	94	2	GO:0106083
GeneOntologyCellularComponent	nuclear membrane microtubule tethering complex	SYNE3 SUN2	1.07e-03	11	94	2	GO:0106094
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPG DMPK	1.46e-04	4	93	2	IPR014930
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPG DMPK	1.46e-04	4	93	2	PD011252
Domain	DMPK_coil	CDC42BPG DMPK	1.46e-04	4	93	2	PF08826
Domain	PH_dom-like	CDC42BPG ACAP1 RGPD8 OBSCN TRIOBP FARP2 PLCB2 PHLPP2 RGPD5	2.72e-04	426	93	9	IPR011993
Domain	ZF_UBR	UBR4 UBR5	5.07e-04	7	93	2	PS51157
Domain	zf-UBR	UBR4 UBR5	5.07e-04	7	93	2	PF02207
Domain	Znf_UBR	UBR4 UBR5	5.07e-04	7	93	2	IPR003126
Domain	ZnF_UBR1	UBR4 UBR5	5.07e-04	7	93	2	SM00396
Domain	SH3_9	RIMBP3 MAP3K10 RIMBP3C RIMBP3B	6.20e-04	78	93	4	PF14604
Domain	DHC_N1	DNAH10 DYNC1H1	6.74e-04	8	93	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH10 DYNC1H1	6.74e-04	8	93	2	IPR013594
Domain	SH3_2	RIMBP3 MAP3K10 RIMBP3C RIMBP3B	8.96e-04	86	93	4	IPR011511
Domain	SH3_2	RIMBP3 MAP3K10 RIMBP3C RIMBP3B	8.96e-04	86	93	4	PF07653
Domain	Pkinase_C	CDC42BPG PKN1 DMPK	1.19e-03	42	93	3	PF00433
Domain	Grip	RGPD8 RGPD5	1.31e-03	11	93	2	SM00755
Domain	GRIP	RGPD8 RGPD5	1.31e-03	11	93	2	PF01465
Domain	Ran_BP1	RGPD8 RGPD5	1.57e-03	12	93	2	PF00638
Domain	GRIP_dom	RGPD8 RGPD5	1.57e-03	12	93	2	IPR000237
Domain	GRIP	RGPD8 RGPD5	1.57e-03	12	93	2	PS50913
Domain	RANBD1	RGPD8 RGPD5	1.57e-03	12	93	2	PS50196
Domain	Nucleotide-bd_a/b_plait	UPF3A SCAF4 SRRT RBM6 HTATSF1 ACIN1	1.83e-03	258	93	6	IPR012677
Domain	RanBD	RGPD8 RGPD5	1.85e-03	13	93	2	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD5	1.85e-03	13	93	2	IPR000156
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DYNC1H1	2.15e-03	14	93	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DYNC1H1	2.15e-03	14	93	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DYNC1H1	2.15e-03	14	93	2	IPR013602
Domain	DHC_N2	DNAH10 DYNC1H1	2.15e-03	14	93	2	PF08393
Domain	MT	DNAH10 DYNC1H1	2.15e-03	14	93	2	PF12777
Domain	AAA_8	DNAH10 DYNC1H1	2.15e-03	14	93	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DYNC1H1	2.15e-03	14	93	2	IPR011704
Domain	AAA_5	DNAH10 DYNC1H1	2.15e-03	14	93	2	PF07728
Domain	DHC_fam	DNAH10 DYNC1H1	2.47e-03	15	93	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DYNC1H1	2.47e-03	15	93	2	IPR004273
Domain	Dynein_heavy	DNAH10 DYNC1H1	2.47e-03	15	93	2	PF03028
Domain	PH	CDC42BPG ACAP1 TEX2 OBSCN TRIOBP FARP2	2.66e-03	278	93	6	SM00233
Domain	PH_DOMAIN	CDC42BPG ACAP1 OBSCN TRIOBP FARP2 PHLPP2	2.71e-03	279	93	6	PS50003
Domain	AGC-kinase_C	CDC42BPG PKN1 DMPK	2.74e-03	56	93	3	IPR000961
Domain	AGC_KINASE_CTER	CDC42BPG PKN1 DMPK	2.74e-03	56	93	3	PS51285
Domain	S_TK_X	CDC42BPG PKN1 DMPK	2.74e-03	56	93	3	SM00133
Domain	PH_domain	CDC42BPG ACAP1 TEX2 OBSCN TRIOBP FARP2	2.76e-03	280	93	6	IPR001849
Domain	-	CDC42BPG ACAP1 RGPD8 OBSCN TRIOBP FARP2 PHLPP2	3.38e-03	391	93	7	2.30.29.30
Domain	Myosin_tail_1	MYH14 CCDC102A	3.56e-03	18	93	2	PF01576
Domain	Myosin_tail	MYH14 CCDC102A	3.56e-03	18	93	2	IPR002928
Domain	WD40_repeat_dom	WDR7 UBR4 BRWD3 STRN FBXW8 TENM3	3.69e-03	297	93	6	IPR017986
Domain	PIPLC_X_DOMAIN	ACAP1 PLCB2	3.97e-03	19	93	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	ACAP1 PLCB2	3.97e-03	19	93	2	IPR000909
Domain	SH3	OBSCN RIMBP3 MAP3K10 RIMBP3C RIMBP3B	4.51e-03	216	93	5	SM00326
Domain	SH3	OBSCN RIMBP3 MAP3K10 RIMBP3C RIMBP3B	4.51e-03	216	93	5	PS50002
Domain	SH3_domain	OBSCN RIMBP3 MAP3K10 RIMBP3C RIMBP3B	4.87e-03	220	93	5	IPR001452
Domain	PH	CDC42BPG ACAP1 OBSCN TRIOBP FARP2	5.75e-03	229	93	5	PF00169
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	8.40e-08	4	97	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	2.09e-07	5	97	3	17855024
Pubmed	Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system.	TEX2 NFKBIL1 RBM6	1.17e-06	8	97	3	10460589
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	DHX36 GPATCH1 UBR4 DIDO1 ZC3H18 SRRT SUN2 ACIN1	5.33e-06	341	97	8	32971831
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	7.49e-06	14	97	3	17662146
Pubmed	Human growth plate contains aggrecan fragments that can be generated by m-calpain.	CAPN2 ACAN	7.70e-06	2	97	2	21117903
Pubmed	G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage.	CAPN2 ACAN	7.70e-06	2	97	2	17261541
Pubmed	Calpain is involved in C-terminal truncation of human aggrecan.	CAPN2 ACAN	7.70e-06	2	97	2	20618160
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	RGPD8 SLC27A6 KRBA2 CYP46A1 UBR5 TRPV6 ZSCAN16 DYNC1H1	8.07e-06	361	97	8	18976975
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX36 WDR7 TRIOBP DIDO1 NUDT16L1 ZC3H18 UPF3A SCAF4 SRRT SUN2 RBM6 ACIN1 DYNC1H1	9.89e-06	1082	97	13	38697112
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	UBR4 UBR5 ANAPC13	1.39e-05	17	97	3	29033132
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DHX36 ZNF346 DIDO1 NUDT16L1 ZC3H18 SCAF4 SRRT RBM6 ACIN1 LSM14A DYNC1H1	1.59e-05	807	97	11	22681889
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	GPATCH1 ZC3H18 SRRT MYH14 ACIN1 DMPK	2.27e-05	202	97	6	24639526
Pubmed	UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.	UBR4 UBR5	2.31e-05	3	97	2	32558906
Pubmed	Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate.	ZC3H18 SRRT	2.31e-05	3	97	2	28297668
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RGPD8 LEO1 ZC3H18 RIMBP3 STRN UBR5 RBM6 BSN TEDC1	4.05e-05	588	97	9	38580884
Pubmed	The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.	UBR4 STRN BSN	4.08e-05	24	97	3	35179492
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR4 UBR5	4.60e-05	4	97	2	16055722
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RGPD8 RGPD5	4.60e-05	4	97	2	9480752
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR4 UBR5	4.60e-05	4	97	2	19008229
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BRIP1 LEO1 DIDO1 ZC3H18 SCAF4 SRRT RBM6 ACIN1 PKN1 ZHX1	6.19e-05	774	97	10	15302935
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	TRIOBP DIDO1 EVPL SCAF4 ACIN1 LSM14A DYNC1H1	6.94e-05	360	97	7	33111431
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	DHX36 NUDT16L1 CEP128 UBR5 RBM6 ACIN1	6.96e-05	247	97	6	32989298
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	UBR4 DIDO1 ZC3H18 CCDC88B CYP46A1 MICU3 HTATSF1	7.07e-05	361	97	7	26167880
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE3 SUN2	7.66e-05	5	97	2	18396275
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD8 LZTS3 WDR7 UBR4 TRIOBP DIDO1 STRN UBR5 PKN1 BSN DYNC1H1	7.88e-05	963	97	11	28671696
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX36 CDC42BPG LEO1 DIDO1 GIGYF1 TARS2 FARP2 SRRT HR	8.72e-05	650	97	9	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX36 UBR4 DIDO1 ZC3H18 UBR5 MYH14 RBM6 ACIN1 DYNC1H1	9.03e-05	653	97	9	22586326
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	LEO1 SRRT HTATSF1 ACIN1 LSM14A	9.68e-05	163	97	5	22113938
Pubmed	Genome-wide association study of comorbid depressive syndrome and alcohol dependence.	WDR7 MICU3	1.15e-04	6	97	2	22064162
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE3 SUN2	1.15e-04	6	97	2	33058875
Pubmed	MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.	CDC42BPG DMPK	1.60e-04	7	97	2	29162624
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD8 RGPD5	1.60e-04	7	97	2	15710750
Pubmed	Human transcription factor protein interaction networks.	DHX36 DNAH10 UBR4 DIDO1 ZC3H18 GIGYF1 SCAF4 SRRT MYH14 RBM6 LSM14A ZHX1 DYNC1H1	1.70e-04	1429	97	13	35140242
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	UBR4 NFKBIL1 HTATSF1 BSN ENDOG ZHX1 DYNC1H1	2.08e-04	430	97	7	35044719
Pubmed	LMO7 deficiency reveals the significance of the cuticular plate for hearing function.	TRIOBP MYH14	2.13e-04	8	97	2	30850599
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	DNAAF3 RBM6 HTATSF1	2.23e-04	42	97	3	32738194
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDC42BPG OBSCN TRIOBP TARS2 BRWD3 FARP2 KLHL29 FBXO16 EXD3 MYH14 RBM6 PKN1 LSM14A	2.53e-04	1489	97	13	28611215
Pubmed	Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.	GIGYF1 LSM14A	2.74e-04	9	97	2	31439631
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR4 UBR5	2.74e-04	9	97	2	17855541
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	ZC3H18 SRRT HTATSF1 ACIN1	3.10e-04	115	97	4	17332742
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	DIDO1 EVPL SRRT RBM6 LSM14A CCDC102A	3.29e-04	329	97	6	34316702
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZNF346 BRIP1 GPATCH1 DIDO1 ZC3H18 SCAF4 SRRT RBM6 HTATSF1 ACIN1	3.36e-04	954	97	10	36373674
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	DHX36 LZTS3 DIDO1 SCAF4 ACIN1	3.89e-04	220	97	5	24550385
Pubmed	Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.	TENM3 SMIM45 DYNC1H1	3.97e-04	51	97	3	16919471
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	GPATCH1 UBR4 DIDO1 ACIN1	4.94e-04	130	97	4	35545047
Pubmed	The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells.	ZC3H18 SRRT	4.99e-04	12	97	2	23793891
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR4 UBR5	4.99e-04	12	97	2	17360488
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	LEO1 DIDO1 GIGYF1 SRRT RBM6 ACIN1 PKN1	5.32e-04	503	97	7	16964243
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	DHX36 LEO1 CAPN2 UBR4 DIDO1 ZC3H18 RDH13 SRRT UBR5 HTATSF1 ACBD3 DYNC1H1	5.75e-04	1415	97	12	28515276
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	UBR4 DUSP9 UBR5	5.81e-04	58	97	3	31067491
Pubmed	Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.	GIGYF1 SRRT	5.89e-04	13	97	2	11239002
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	TEX2 ZC3H18 SRRT HTATSF1 ACIN1	6.22e-04	244	97	5	29884807
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	LEO1 UPF3A GIGYF1 FARP2 DNAAF3 SRRT FBXW8 UBR5 LSM14A TEDC1	6.47e-04	1038	97	10	26673895
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD8 LEO1 UBR4 KRBA2 CEP128 STRN MYPOP MYH14 ACIN1 LSM14A BSN RGPD5	6.79e-04	1442	97	12	35575683
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	UBR4 UBR5	6.85e-04	14	97	2	27626314
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DYNC1H1	6.85e-04	14	97	2	9373155
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	UBR4 BRWD3 UBR5	7.06e-04	62	97	3	18775313
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	LEO1 ZC3H18 SCAF4 MYH14 ACIN1	7.06e-04	251	97	5	31076518
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	DHX36 SRRT RBM6 ACIN1 LSM14A	7.99e-04	258	97	5	37794589
Pubmed	K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.	UBR4 UBR5 RBM6	8.10e-04	65	97	3	29378950
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	DHX36 NUDT16L1 ZC3H18 TARS2 SCAF4 SRRT HTATSF1 ACIN1	8.74e-04	713	97	8	29802200
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	CDC42BPG UBR5 MYH14 DYNC1H1 TEDC1	8.86e-04	264	97	5	32814769
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF346 TRIOBP DIDO1 RDH13 SCAF4 FARP2 SRRT STRN SUN2 RBM6 LSM14A ZHX1	9.40e-04	1497	97	12	31527615
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	GPATCH1 UBR4 UBR5 MYH14 DYNC1H1	9.63e-04	269	97	5	29511261
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	LEO1 GPATCH1 DIDO1 ZC3H18 SCAF4 SRRT MYPOP SUN2 NFKBIL1 HTATSF1 ACIN1	9.67e-04	1294	97	11	30804502
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	DHX36 UBR5 SUN2 RBM6	9.76e-04	156	97	4	29961565
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	RGPD8 LZTS3 GPATCH1 TRIOBP CCDC88B SRRT LSM14A	9.96e-04	560	97	7	21653829
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WDR7 KLHL29 TENM3 UBR5 ACIN1 DYNC1H1	9.99e-04	407	97	6	12693553
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	DNAH10 CAPN2 BCL2L2 TARS2 STRN PLCB2 DMPK UAP1L1	1.02e-03	730	97	8	34857952
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	UBR4 TRIOBP STRN UBR5 LSM14A DYNC1H1 PHLPP2	1.14e-03	573	97	7	28330616
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	LZTS3 WDR7 STRN UBR5 DYNC1H1	1.17e-03	281	97	5	28706196
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	WDR7 TEX2 DIDO1 UBR5 RBM6 HTATSF1 ACBD3 DYNC1H1	1.25e-03	754	97	8	35906200
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	ZNF346 ZC3H18 RDH13 TARS2 CEP128 UBR5 MYH14 SUN2	1.25e-03	754	97	8	33060197
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	CAPN2 FARP2 UBR5 ACIN1	1.26e-03	167	97	4	25659891
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RGPD8 LZTS3 TEX2 CAPN2 UBR4 TRIOBP STRN MICU3 MAP3K10 BSN	1.31e-03	1139	97	10	36417873
Pubmed	Functional proteomics mapping of a human signaling pathway.	UBR4 STRN TENM3 UBR5 HTATSF1 ACBD3 DYNC1H1	1.36e-03	591	97	7	15231748
Pubmed	Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.	DIDO1 RDH13 SUN2 RBM6	1.37e-03	171	97	4	36629882
Pubmed	Recruitment of the human TREX complex to mRNA during splicing.	SRRT ACIN1	1.42e-03	20	97	2	15998806
Pubmed	Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.	BSN ANAPC13	1.42e-03	20	97	2	20846217
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	UBR4 UBR5	1.56e-03	21	97	2	37422473
Pubmed	Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.	UBR4 UBR5	1.56e-03	21	97	2	26582913
Pubmed	SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis.	MYH14 ACAN	1.56e-03	21	97	2	30021842
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	UBR4 UBR5 DYNC1H1	1.70e-03	84	97	3	29563501
Pubmed	Genome-wide association analysis identifies 20 loci that influence adult height.	ACAN ANAPC13	1.71e-03	22	97	2	18391952
Pubmed	Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.	BICDL1 DYNC1H1	1.87e-03	23	97	2	20360680
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	OBSCN UAP1L1	1.87e-03	23	97	2	29768498
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	GPATCH1 UBR4 ZC3H18 FARP2 NFKBIL1	1.88e-03	313	97	5	38270169
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	ZC3H18 SRRT ACIN1 ACBD3	1.94e-03	188	97	4	29721183
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	LEO1 UBR5 HTATSF1 BSN DYNC1H1	1.98e-03	317	97	5	17620599
Pubmed	A protein interaction landscape of breast cancer.	BRIP1 UBR4 ZC3H18 SCAF4 FBXW8 UBR5 ACIN1	2.02e-03	634	97	7	34591612
Pubmed	OTUB1 modulates c-IAP1 stability to regulate signalling pathways.	UBR4 UBR5	2.04e-03	24	97	2	23524849
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	ACIN1 DYNC1H1	2.04e-03	24	97	2	33705438
Pubmed	Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.	TRIOBP RIMBP3	2.04e-03	24	97	2	11258795
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	LEO1 CAPN2 UBR4 DIDO1 ZC3H18 SRRT UBR5 HTATSF1 ACIN1	2.13e-03	1014	97	9	32416067
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	DUSP9 OBSCN BCL2L2 BRWD3 SUN2 RBM6 ACIN1 DMPK TEDC1	2.23e-03	1021	97	9	26760575
Pubmed	Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.	DHX36 SRRT ASB10 RBM6	2.34e-03	198	97	4	24337577
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	UBR4 DIDO1 SRRT ACIN1 DYNC1H1	2.42e-03	332	97	5	32786267
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	DHX36 ZC3H18 GIGYF1 UBR5 SUN2 ACIN1 LSM14A	2.42e-03	655	97	7	35819319
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	SLC27A6 GPATCH1 CAPN2 TRIOBP MYH14 DYNC1H1	2.50e-03	488	97	6	31324722
Interaction	GAGE5 interactions	TRIOBP DIDO1 SCAF4 MYH14 RBM6	3.90e-06	52	92	5	int:GAGE5
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR4 UBR5	2.56e-04	7	64	2	785
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CDC42BPG ACAP1 TRIOBP FARP2 PHLPP2	8.08e-04	206	64	5	682
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	C8orf74 CYP46A1 EOLA2 ACAN BSN ENDOG	5.15e-07	135	97	6	c7c30b993b3ddac8f1677d5fe47dc2e66d0d26ac
Drug	Bumetanide [28395-03-1]; Down 200; 11uM; MCF7; HT_HG-U133A	LZTS3 SLC27A6 TRIOBP UPF3A ATP8B2 BICDL1 STRN DMPK	1.61e-06	197	94	8	7440_DN
Disease	hippocampal volume	DIDO1 ATP8B2 DACT1 STRN FBXW8	2.19e-03	297	90	5	EFO_0005035

Protein segments in the cluster

Peptide	Gene	Start	Entry
REQERAVREQWAERE	ACIN1	1136	Q9UKV3
RDWEGDACRELLVER	EOLA2	46	Q96DE9
EPDTDWEEREVRRRQ	AQP2	241	P41181
EDWRFRRGVEREKQD	CEP128	346	Q6ZU80
RERLRRLLNWEEFDE	C8orf74	21	Q6P047
EALAAAGRERRQWER	CCDC88B	816	A6NC98
AGRERRQWEREGSRL	CCDC88B	821	A6NC98
DPERWRDFRFNIRAL	ASB10	91	Q8WXI3
LEEARRLREGNWASV	BCL2L2	156	Q92843
RNWQIGDRFRSIIDD	BRWD3	1046	Q6RI45
REARRDFWRGAESLE	ACAP1	121	Q15027
ELRRRFENREGEWEG	BICDL1	151	Q6ZP65
SWGTEEERRARANDR	ATP8B2	26	P98198
LFRFDAEVRQWKERG	RGPD5	1066	Q99666
LFRFDAEVRQWKERG	RGPD8	1066	O14715
LRAELEAERAGWRAE	RIMBP3B	36	A6NNM3
EAERAGWRAERRRFA	RIMBP3B	41	A6NNM3
LRAELEAERAGWRAE	RIMBP3C	36	A6NJZ7
EAERAGWRAERRRFA	RIMBP3C	41	A6NJZ7
FREERDVLVKGDSRW	CDC42BPG	116	Q6DT37
ETVRRGTELWERDRE	NOTCH2NLB	251	P0DPK3
VENTIRWRIRRDEEG	LEO1	416	Q8WVC0
VAEARAADGEEQRRW	MAP3K10	691	Q02779
QGDEDVLFRVTERWR	MADCAM1	176	Q13477
RERQGASFAEERRVW	LZTS3	591	O60299
EIQRSQSWDDRGERR	GIGYF1	151	O75420
DGDFWIGLRRREEKQ	LAYN	101	Q6UX15
DSAEWRRRREQQDTA	BSN	786	Q9UPA5
DEDSAEWEQPVRRRR	BSN	2616	Q9UPA5
RREREALAWAQREGQ	HR	571	O43593
EWERGRERDEFARAA	GPATCH1	541	Q9BRR8
LDEFRRRWQEELAQA	FBXW8	6	Q8N3Y1
SEWRRRQEEEAGALE	MYH14	1391	Q7Z406
GERDEWRRERAKVET	EVPL	1296	Q92817
GRRRRGEAEAEAEEW	DUSP9	86	Q99956
DDNRERRPTWAEERR	LSM14A	376	Q8ND56
EARRLEQRWGFGLEE	ACBD3	71	Q9H3P7
REDEERAVAEAAWRR	MICU3	46	Q86XE3
WRQQEEEQRLFRERA	NFKBIL1	236	Q9UBC1
ERADTRRWRFDATLE	PADI3	61	Q9ULW8
DLDWDRRRIQGARAT	RIBC2	311	Q9H4K1
FREERDVLVNGDRRW	DMPK	116	Q09013
PDRETWVDAERRCRE	ACAN	2336	P16112
EDEEVARRLWAESAR	RDH13	301	Q8NBN7
RNDWGALILVDDRFR	BRIP1	836	Q9BX63
EETSREREERLRGWE	HTATSF1	356	O43719
EREERLRGWEAFLNA	HTATSF1	361	O43719
VEWRKGRESLRDGDR	OBSCN	3391	Q5VST9
QRDGRILDLIDDAWR	ANAPC13	6	Q9BS18
EERERILREIWRTGQ	EVA1B	126	Q9NVM1
WREKGEADTERQRTR	DACT1	31	Q9NYF0
RRWRDTGVAFELRDS	DNAAF3	231	Q8N9W5
DWVQRRREALKRGEE	CYP46A1	256	Q9Y6A2
NAFEGWEEARRRGFR	DHX36	761	Q9H2U1
QAENAAEWGRRERLE	CCDC102A	351	Q96A19
NRDREREADRGKEWD	DIDO1	2156	Q9BTC0
READRGKEWDRSRER	DIDO1	2161	Q9BTC0
RLFQDRLVEDEERRW	DYNC1H1	2831	Q14204
WEETRVLAFAQRERI	FOXR2	281	Q6PJQ5
NDRVFEERRALLGKW	FBXO16	31	Q8IX29
RGFLREVEQRLALWE	FARP2	591	O94887
ERERLTRRHEDGEFW	CAPN2	311	P17655
ASGREDRWEFDRKRL	DNAH10	446	Q8IVF4
DDRDNSNRDRREWGR	SCAF4	1021	O95104
WIRQEERAEIGADRS	KRBA2	451	Q6ZNG9
VNIRTRDNRRLGEWD	TARS2	681	Q9BW92
FRRDRERESWSGETR	RBM6	636	P78332
ARFEVERAQWEVERA	STRN	61	O43815
AWLEGRIRQEFDKLR	TRIM35	181	Q9UPQ4
WEEEEERLRGLLRSR	SYNE3	316	Q6ZMZ3
LRAELEAERAGWRAE	RIMBP3	36	Q9UFD9
EAERAGWRAERRRFA	RIMBP3	41	Q9UFD9
LGAVVEGWRRRREDA	ENDOG	16	Q14249
ERLSRRSEDEQRWGK	UPF3A	376	Q9H1J1
ARELELAVFWRDQRG	PKN1	426	Q16512
GLQEERANDEFRWRD	PLA2R1	876	Q13018
ERDLAQRSEERRKWF	TRIOBP	1976	Q9H2D6
SRERDERRRGDDWND	SRRT	26	Q9BXP5
GDANWGEDLRVRRRR	SUN2	91	Q9UH99
FGSRERDWLREDVKR	PHLPP2	16	Q6ZVD8
QDPREVRRRAADWAE	SPEM2	376	Q0P670
FVDRRFWSLEDGLNR	NUDT16L1	66	Q9BRJ7
ELREAAERRRAAWEA	TEDC1	371	Q86SX3
EWFAERQRRSELGIE	ZHX1	816	Q9UKY1
DPETRRRWEEEGFRQ	UAP1L1	86	Q3KQV9
GDRWFLRVEDRQDLN	TRPV6	666	Q9H1D0
RAWAREQQRVRDGEE	TENM3	2631	Q9P273
RVDGFLGQWERAQRE	TSKS	361	Q9UJT2
ELERRGARRWEELLQ	PLCB2	911	Q00722
DRTEWVQIRRLEAAG	ZC2HC1C	206	Q53FD0
FSRDRREDETWGRSQ	ZC2HC1C	296	Q53FD0
FDRERARRLWEAVSG	ZNF346	36	Q9UL40
ENEGRSEWQQRERRR	ZSCAN16	221	Q9H4T2
GDAERRQRWGRLFEE	SLC25A23	6	Q9BV35
RSDVWREFLDRFGNI	SLC27A6	341	Q9Y2P4
GRTGREKEEWFRRFI	TEX2	691	Q8IWB9
RVGEERERERERVWG	SMIM45	86	A0A590UK83
RLARGREEWESAALQ	UBR4	4896	Q5T4S7
RRIEQAGRKEAIDAW	WDR7	1036	Q9Y4E6
LDFWRAGRKREDIQL	TOR1B	226	O14657
RLRERRWLDGASFDN	UBR5	316	O95071
EVFRDWNSRIPRDVR	ZC3H18	346	Q86VM9
SRFERDYRVGWDRRE	KLHL29	6	Q96CT2
RERKQLREEAWRGFA	EXD3	36	Q8N9H8
RVSVAERRRVWDGIA	MYPOP	46	Q86VE0