Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

LAMC1 LTBP1 FBN2 SSPOP LTBP4 COL1A1

2.20e-06188416GO:0005201
GeneOntologyMolecularFunctiontransforming growth factor beta receptor activity

BMPR2 LTBP1 LTBP4

2.27e-0613413GO:0005024
GeneOntologyMolecularFunctiontransmembrane receptor protein serine/threonine kinase activity

BMPR2 LTBP1 LTBP4

8.94e-0620413GO:0004675
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

LAMC1 FBN2

2.68e-0412412GO:0030023
GeneOntologyMolecularFunctiongrowth factor binding

BMPR2 LTBP1 LTBP4 COL1A1

2.90e-04156414GO:0019838
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

LAMC1 FBN2

3.69e-0414412GO:0097493
GeneOntologyMolecularFunctionstructural molecule activity

LAMC1 KRTAP24-1 LTBP1 FBN2 SSPOP LTBP4 KRTAP3-1 COL1A1

3.92e-04891418GO:0005198
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

BMPR2 LTBP1 LTBP4

7.06e-0485413GO:0019199
GeneOntologyMolecularFunctiontransforming growth factor beta binding

LTBP1 LTBP4

1.30e-0326412GO:0050431
GeneOntologyMolecularFunctionNotch binding

NOTCH1 NOTCH4

1.40e-0327412GO:0005112
GeneOntologyMolecularFunctiontranscription coactivator activity

MED13 TRIM5 NOTCH1 RBCK1

3.38e-03303414GO:0003713
GeneOntologyBiologicalProcessnegative regulation of cell proliferation involved in heart valve morphogenesis

BMPR2 NOTCH1

3.48e-062392GO:0003252
GeneOntologyBiologicalProcessvenous blood vessel development

BMPR2 NOTCH1 NOTCH4

6.97e-0620393GO:0060841
GeneOntologyBiologicalProcessregulation of cell proliferation involved in heart valve morphogenesis

BMPR2 NOTCH1

1.04e-053392GO:0003250
GeneOntologyBiologicalProcesscell proliferation involved in heart valve morphogenesis

BMPR2 NOTCH1

1.04e-053392GO:0003249
GeneOntologyBiologicalProcesscollagen biosynthetic process

LTBP1 DICER1 NOTCH1 COL1A1

1.27e-0576394GO:0032964
GeneOntologyBiologicalProcessnegative regulation of cell proliferation involved in heart morphogenesis

BMPR2 NOTCH1

2.09e-054392GO:2000137
GeneOntologyBiologicalProcesspositive regulation of aorta morphogenesis

NOTCH1 NOTCH4

2.09e-054392GO:1903849
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

LTBP1 FBN2

2.09e-054392GO:0035583
GeneOntologyBiologicalProcesscell proliferation involved in heart valve development

BMPR2 NOTCH1

2.09e-054392GO:2000793
GeneOntologyBiologicalProcesshair follicle cell proliferation

LAMC1 DICER1

3.47e-055392GO:0071335
GeneOntologyBiologicalProcessbiomineral tissue development

BMPR2 FBN2 DICER1 NOTCH1 COL1A1

3.86e-05203395GO:0031214
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

VWC2 BMPR2 LTBP1 FBN2 LTBP4 NOTCH1

4.43e-05347396GO:0090092
GeneOntologyBiologicalProcessregulation of aorta morphogenesis

NOTCH1 NOTCH4

5.20e-056392GO:1903847
GeneOntologyBiologicalProcesshair follicle morphogenesis

LAMC1 DICER1 NOTCH1

5.88e-0540393GO:0031069
GeneOntologyBiologicalProcessregulation of biomineral tissue development

BMPR2 FBN2 DICER1 NOTCH1

6.27e-05114394GO:0070167
GeneOntologyBiologicalProcesspositive regulation of transcription of Notch receptor target

NOTCH1 NOTCH4

7.27e-057392GO:0007221
GeneOntologyBiologicalProcessepidermis morphogenesis

LAMC1 DICER1 NOTCH1

8.97e-0546393GO:0048730
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

LTBP1 FBN2

9.68e-058392GO:0071694
GeneOntologyBiologicalProcesscell-substrate adhesion

LYPD3 VWC2 LAMC1 DICER1 NOTCH1 COL1A1

1.11e-04410396GO:0031589
GeneOntologyBiologicalProcessartery development

BMPR2 LTBP1 NOTCH1 NOTCH4

1.14e-04133394GO:0060840
GeneOntologyBiologicalProcesspositive regulation of artery morphogenesis

NOTCH1 NOTCH4

1.24e-049392GO:1905653
GeneOntologyBiologicalProcessnegative regulation of cell-cell adhesion mediated by cadherin

NOTCH1 NOTCH4

1.55e-0410392GO:2000048
GeneOntologyBiologicalProcesstrabecula morphogenesis

FBN2 NOTCH1 COL1A1

1.70e-0457393GO:0061383
GeneOntologyBiologicalProcesscollagen metabolic process

LTBP1 DICER1 NOTCH1 COL1A1

1.72e-04148394GO:0032963
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

VWC2 BMPR2 LTBP1 FBN2 LTBP4 NOTCH1

1.74e-04445396GO:0141091
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

LTBP1 FBN2

1.90e-0411392GO:0035581
GeneOntologyBiologicalProcessregulation of viral life cycle

TRIM6 DICER1 TRIM5 NOTCH1

2.11e-04156394GO:1903900
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

ADAMTS20 VWC2 LAMC1 BMPR2 FBN2 DICER1 NOTCH1 NOTCH4 COL1A1

2.21e-041141399GO:0045597
GeneOntologyBiologicalProcessendothelial cell differentiation

BMPR2 DICER1 NOTCH1 NOTCH4

2.21e-04158394GO:0045446
GeneOntologyBiologicalProcessregulation of collagen biosynthetic process

LTBP1 DICER1 NOTCH1

2.52e-0465393GO:0032965
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

VWC2 BMPR2 LTBP1 FBN2 LTBP4 NOTCH1

2.68e-04482396GO:0007178
GeneOntologyBiologicalProcessvenous blood vessel morphogenesis

NOTCH1 NOTCH4

2.68e-0413392GO:0048845
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

LTBP1 FBN2

2.68e-0413392GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

LTBP1 FBN2

2.68e-0413392GO:1900116
GeneOntologyBiologicalProcessregulation of endothelial cell differentiation

DICER1 NOTCH1 NOTCH4

2.75e-0467393GO:0045601
GeneOntologyBiologicalProcessregulation of cell adhesion

TMEM131L VWC2 LAMC1 TRPV4 DICER1 NOTCH1 NOTCH4 COL1A1

2.87e-04927398GO:0030155
GeneOntologyBiologicalProcessbone trabecula formation

FBN2 COL1A1

3.12e-0414392GO:0060346
GeneOntologyBiologicalProcessmitral valve morphogenesis

BMPR2 NOTCH1

3.60e-0415392GO:0003183
GeneOntologyBiologicalProcessendothelium development

BMPR2 DICER1 NOTCH1 NOTCH4

3.79e-04182394GO:0003158
GeneOntologyBiologicalProcessmitral valve development

BMPR2 NOTCH1

4.11e-0416392GO:0003174
GeneOntologyBiologicalProcessnegative regulation of cell adhesion molecule production

NOTCH1 NOTCH4

4.11e-0416392GO:0060354
GeneOntologyBiologicalProcessregulation of viral process

TRIM6 DICER1 TRIM5 NOTCH1

4.11e-04186394GO:0050792
GeneOntologyBiologicalProcessregulation of collagen metabolic process

LTBP1 DICER1 NOTCH1

4.15e-0477393GO:0010712
GeneOntologyBiologicalProcessconnective tissue development

TRPV4 BMPR2 DICER1 NOTCH1 COL1A1

4.47e-04343395GO:0061448
GeneOntologyBiologicalProcessendochondral bone morphogenesis

TRPV4 BMPR2 COL1A1

4.47e-0479393GO:0060350
GeneOntologyBiologicalProcessaorta development

LTBP1 NOTCH1 NOTCH4

4.64e-0480393GO:0035904
GeneOntologyBiologicalProcessregulation of artery morphogenesis

NOTCH1 NOTCH4

4.65e-0417392GO:1905651
GeneOntologyBiologicalProcessanimal organ morphogenesis

MUC19 LAMC1 TRPV4 BMPR2 FBN2 DICER1 HCN1 NOTCH1 COL1A1

4.85e-041269399GO:0009887
GeneOntologyBiologicalProcessbone trabecula morphogenesis

FBN2 COL1A1

5.23e-0418392GO:0061430
GeneOntologyBiologicalProcessregulation of muscle cell differentiation

LAMC1 BMPR2 NOTCH1 NOTCH4

5.31e-04199394GO:0051147
GeneOntologyBiologicalProcessmesenchyme development

BMPR2 DICER1 NOTCH1 NOTCH4 COL1A1

6.46e-04372395GO:0060485
GeneOntologyBiologicalProcessNotch signaling pathway

TIMP4 DICER1 NOTCH1 NOTCH4

6.50e-04210394GO:0007219
GeneOntologyBiologicalProcessretina development in camera-type eye

BMPR2 HCN1 NOTCH1 ARSG

6.61e-04211394GO:0060041
GeneOntologyBiologicalProcessnegative regulation of cell adhesion

TMEM131L TRPV4 NOTCH1 NOTCH4 COL1A1

6.70e-04375395GO:0007162
GeneOntologyBiologicalProcessregulation of viral genome replication

TRIM6 DICER1 NOTCH1

6.77e-0491393GO:0045069
GeneOntologyBiologicalProcessventricular septum development

BMPR2 LTBP1 NOTCH1

6.77e-0491393GO:0003281
GeneOntologyBiologicalProcessextracellular matrix organization

ADAMTS20 LAMC1 LTBP4 NOTCH1 COL1A1

6.86e-04377395GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

ADAMTS20 LAMC1 LTBP4 NOTCH1 COL1A1

6.94e-04378395GO:0043062
GeneOntologyBiologicalProcessartery morphogenesis

BMPR2 NOTCH1 NOTCH4

6.99e-0492393GO:0048844
GeneOntologyBiologicalProcessexternal encapsulating structure organization

ADAMTS20 LAMC1 LTBP4 NOTCH1 COL1A1

7.03e-04379395GO:0045229
GeneOntologyBiologicalProcessregulation of cell proliferation involved in heart morphogenesis

BMPR2 NOTCH1

7.15e-0421392GO:2000136
GeneOntologyBiologicalProcessregulation of cell-cell adhesion mediated by cadherin

NOTCH1 NOTCH4

7.15e-0421392GO:2000047
GeneOntologyBiologicalProcessoutflow tract morphogenesis

BMPR2 DICER1 NOTCH1

7.44e-0494393GO:0003151
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

VWC2 LTBP1 FBN2 NOTCH1

7.47e-04218394GO:0090101
GeneOntologyBiologicalProcessretinal cone cell differentiation

HCN1 NOTCH1

7.86e-0422392GO:0042670
GeneOntologyBiologicalProcesslimb development

BMPR2 FBN2 DICER1 NOTCH1

8.27e-04224394GO:0060173
GeneOntologyBiologicalProcessappendage development

BMPR2 FBN2 DICER1 NOTCH1

8.27e-04224394GO:0048736
GeneOntologyBiologicalProcessregulation of cell adhesion molecule production

NOTCH1 NOTCH4

8.60e-0423392GO:0060353
GeneOntologyBiologicalProcesscell proliferation involved in heart morphogenesis

BMPR2 NOTCH1

8.60e-0423392GO:0061323
GeneOntologyBiologicalProcessregulation of stem cell differentiation

TRIM6 DICER1 NOTCH1

8.65e-0499393GO:2000736
GeneOntologyBiologicalProcesspulmonary valve development

BMPR2 NOTCH1

9.37e-0424392GO:0003177
GeneOntologyBiologicalProcessnegative regulation of glial cell proliferation

DICER1 NOTCH1

9.37e-0424392GO:0060253
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

VWC2 BMPR2 LTBP1 FBN2 LTBP4 NOTCH1 COL1A1

9.55e-04850397GO:0071363
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

VWC2 LTBP1 FBN2 LTBP4 NOTCH1

1.02e-03412395GO:0090287
GeneOntologyBiologicalProcesspositive regulation of muscle cell differentiation

LAMC1 NOTCH1 NOTCH4

1.05e-03106393GO:0051149
GeneOntologyBiologicalProcesscell adhesion molecule production

NOTCH1 NOTCH4

1.10e-0326392GO:0060352
GeneOntologyBiologicalProcesscartilage development

TRPV4 BMPR2 DICER1 COL1A1

1.12e-03243394GO:0051216
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

TMEM131L TRPV4 BMPR2 TRIM6 DICER1 NOTCH1 NOTCH4

1.13e-03875397GO:0045596
GeneOntologyBiologicalProcessresponse to growth factor

VWC2 BMPR2 LTBP1 FBN2 LTBP4 NOTCH1 COL1A1

1.19e-03883397GO:0070848
GeneOntologyBiologicalProcessmaintenance of protein location

LTBP1 FBN2 RBCK1

1.24e-03112393GO:0045185
GeneOntologyBiologicalProcessatrioventricular valve morphogenesis

BMPR2 NOTCH1

1.28e-0328392GO:0003181
GeneOntologyBiologicalProcesspositive regulation of smooth muscle cell differentiation

NOTCH1 NOTCH4

1.28e-0328392GO:0051152
GeneOntologyBiologicalProcessnegative regulation of cell-cell adhesion

TMEM131L TRPV4 NOTCH1 NOTCH4

1.28e-03252394GO:0022408
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

DICER1 NOTCH1 NOTCH4

1.30e-03114393GO:0008593
GeneOntologyBiologicalProcessregulation of cell-substrate adhesion

VWC2 DICER1 NOTCH1 COL1A1

1.32e-03254394GO:0010810
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

VWC2 BMPR2 LTBP1 FBN2 LTBP4 NOTCH1 DOK7 COL1A1

1.45e-031186398GO:0007167
GeneOntologyBiologicalProcesshair follicle development

LAMC1 DICER1 NOTCH1

1.62e-03123393GO:0001942
GeneOntologyBiologicalProcesslung development

MUC19 BMPR2 DICER1 NOTCH1

1.63e-03269394GO:0030324
GeneOntologyBiologicalProcessbone morphogenesis

TRPV4 BMPR2 COL1A1

1.65e-03124393GO:0060349
GeneOntologyBiologicalProcessatrioventricular valve development

BMPR2 NOTCH1

1.67e-0332392GO:0003171
GeneOntologyBiologicalProcesstrabecula formation

FBN2 COL1A1

1.67e-0332392GO:0060343
GeneOntologyBiologicalProcessrespiratory tube development

MUC19 BMPR2 DICER1 NOTCH1

1.72e-03273394GO:0030323
GeneOntologyBiologicalProcessmolting cycle process

LAMC1 DICER1 NOTCH1

1.73e-03126393GO:0022404
GeneOntologyBiologicalProcesshair cycle process

LAMC1 DICER1 NOTCH1

1.73e-03126393GO:0022405
GeneOntologyBiologicalProcessnegative regulation of stem cell differentiation

TRIM6 NOTCH1

1.77e-0333392GO:2000737
GeneOntologyBiologicalProcessskeletal system morphogenesis

TRPV4 BMPR2 FBN2 COL1A1

1.81e-03277394GO:0048705
GeneOntologyCellularComponentmicrofibril

LTBP1 FBN2 LTBP4

2.45e-0613443GO:0001527
GeneOntologyCellularComponentextracellular matrix

ADAMTS20 VWC2 LAMC1 LTBP1 FBN2 TIMP4 SSPOP LTBP4 COL1A1

7.41e-06656449GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS20 VWC2 LAMC1 LTBP1 FBN2 TIMP4 SSPOP LTBP4 COL1A1

7.59e-06658449GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

ADAMTS20 VWC2 LAMC1 LTBP1 FBN2 SSPOP LTBP4 COL1A1

1.29e-05530448GO:0062023
DomainTB

LTBP1 FBN2 LTBP4

2.93e-077393PF00683
Domain-

LTBP1 FBN2 LTBP4

4.68e-0783933.90.290.10
DomainTB

LTBP1 FBN2 LTBP4

7.01e-079393PS51364
DomainTB_dom

LTBP1 FBN2 LTBP4

7.01e-079393IPR017878
DomainGrowth_fac_rcpt_

LAMC1 LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

8.01e-07156396IPR009030
DomainEGF_1

LAMC1 LTBP1 FBN2 SSPOP LTBP4 NOTCH1 NOTCH4

8.63e-07255397PS00022
DomainEGF_CA

LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

9.37e-0786395PF07645
DomainEGF_2

LAMC1 LTBP1 FBN2 SSPOP LTBP4 NOTCH1 NOTCH4

1.12e-06265397PS01186
DomainVWC

MUC19 VWC2 SSPOP COL1A1

1.14e-0638394SM00214
DomainVWFC_2

MUC19 VWC2 SSPOP COL1A1

1.14e-0638394PS50184
DomainEGF_Ca-bd_CS

LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

1.70e-0697395IPR018097
DomainVWF_dom

MUC19 VWC2 SSPOP COL1A1

1.72e-0642394IPR001007
DomainEGF_CA

LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

1.89e-0699395PS01187
DomainASX_HYDROXYL

LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

1.98e-06100395PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

2.64e-06106395IPR000152
DomainEGF_CA

LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

5.28e-06122395SM00179
DomainEGF-like_Ca-bd_dom

LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

5.72e-06124395IPR001881
DomainEGF_3

LTBP1 FBN2 SSPOP LTBP4 NOTCH1 NOTCH4

8.58e-06235396PS50026
DomainEGF

LAMC1 LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

8.58e-06235396SM00181
DomainEGF-like_dom

LAMC1 LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

1.19e-05249396IPR000742
DomainEGF-like_CS

LAMC1 LTBP1 FBN2 LTBP4 NOTCH1 NOTCH4

1.56e-05261396IPR013032
DomainNOD

NOTCH1 NOTCH4

2.54e-054392PF06816
DomainNotch

NOTCH1 NOTCH4

2.54e-054392IPR008297
DomainNODP

NOTCH1 NOTCH4

2.54e-054392PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH4

2.54e-054392IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH4

2.54e-054392IPR010660
DomainNOD

NOTCH1 NOTCH4

2.54e-054392SM01338
DomainNODP

NOTCH1 NOTCH4

2.54e-054392SM01339
DomainhEGF

FBN2 NOTCH1 NOTCH4

2.66e-0528393PF12661
DomainLNR

NOTCH1 NOTCH4

4.23e-055392PS50258
DomainKeratin_matx

KRTAP24-1 KRTAP3-1

4.23e-055392IPR007659
DomainZnf-RING_LisH

TRIM6 TRIM5 RBCK1

4.82e-0534393IPR027370
Domainzf-RING_UBOX

TRIM6 TRIM5 RBCK1

4.82e-0534393PF13445
DomainVWFC_1

VWC2 SSPOP COL1A1

5.73e-0536393PS01208
DomainNotch_dom

NOTCH1 NOTCH4

8.86e-057392IPR000800
DomainNotch

NOTCH1 NOTCH4

8.86e-057392PF00066
DomainNL

NOTCH1 NOTCH4

8.86e-057392SM00004
DomainTIL

MUC19 SSPOP

2.77e-0412392PF01826
DomainC8

MUC19 SSPOP

2.77e-0412392PF08742
DomainUnchr_dom_Cys-rich

MUC19 SSPOP

3.27e-0413392IPR014853
DomainC8

MUC19 SSPOP

3.27e-0413392SM00832
DomainTIL_dom

MUC19 SSPOP

3.81e-0414392IPR002919
DomainVWFD

MUC19 SSPOP

5.01e-0416392PS51233
DomainVWD

MUC19 SSPOP

5.01e-0416392SM00216
DomainVWF_type-D

MUC19 SSPOP

5.01e-0416392IPR001846
DomainVWD

MUC19 SSPOP

5.01e-0416392PF00094
DomainLU

LYPD3 LYPD2

5.01e-0416392SM00134
DomainZF_BBOX

TRIM6 TRIM5 RBCK1

6.19e-0480393PS50119
DomainCTCK_1

MUC19 SSPOP

6.36e-0418392PS01185
DomainZnf_B-box

TRIM6 TRIM5 RBCK1

6.42e-0481393IPR000315
DomainVWC_out

MUC19 SSPOP

7.10e-0419392SM00215
DomainUPAR_LY6

LYPD3 LYPD2

7.88e-0420392PF00021
DomainLY6_UPAR

LYPD3 LYPD2

9.56e-0422392PS00983
DomainLY6_UPA_recep-like

LYPD3 LYPD2

9.56e-0422392IPR016054
DomainCys_knot_C

MUC19 SSPOP

1.24e-0325392IPR006207
DomainCTCK_2

MUC19 SSPOP

1.24e-0325392PS01225
DomaincEGF

LTBP1 FBN2

1.34e-0326392IPR026823
DomaincEGF

LTBP1 FBN2

1.34e-0326392PF12662
DomainVWC

VWC2 COL1A1

1.55e-0328392PF00093
DomainIon_trans_dom

TRPM6 TRPV4 HCN1

1.72e-03114393IPR005821
DomainIon_trans

TRPM6 TRPV4 HCN1

1.72e-03114393PF00520
DomainEGF

LTBP1 NOTCH1 NOTCH4

2.29e-03126393PF00008
Domain-

PHF7 TRIM6 TRIM5 RBCK1 PYGO1

2.31e-034493953.30.40.10
DomainZnf_RING/FYVE/PHD

PHF7 TRIM6 TRIM5 RBCK1 PYGO1

2.54e-03459395IPR013083
DomainZF_RING_1

PHF7 TRIM6 TRIM5 RBCK1

3.09e-03291394PS00518
DomainZF_RING_2

PHF7 TRIM6 TRIM5 RBCK1

3.37e-03298394PS50089
DomainRING

PHF7 TRIM6 TRIM5 RBCK1

3.66e-03305394SM00184
DomainZnf_RING

PHF7 TRIM6 TRIM5 RBCK1

4.63e-03326394IPR001841
DomainZnf_RING_CS

TRIM6 TRIM5 RBCK1

4.74e-03163393IPR017907
DomainZnf_C3HC4_RING-type

TRIM6 TRIM5 RBCK1

5.50e-03172393IPR018957
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS20 SSPOP NOTCH1 NOTCH4

1.41e-0568314M27303
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP1 FBN2 LTBP4

4.57e-0532313MM14854
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH4

4.66e-055312M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH4

4.66e-055312MM14733
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH4

6.98e-056312M27068
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP1 FBN2 LTBP4

7.11e-0537313M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP1 FBN2 LTBP4

8.34e-0539313MM14601
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH1 NOTCH4

9.76e-057312MM14734
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP1 FBN2 LTBP4

1.20e-0444313M26969
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

LTBP1 LTBP4

1.30e-048312M47850
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH1 NOTCH4

2.54e-0411312M47865
PathwayWP_ENDODERM_DIFFERENTIATION

ZNF462 LAMC1 TRIM5 NOTCH1

2.58e-04143314M39591
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS20 SSPOP NOTCH1 NOTCH4

2.58e-04143314M27275
PathwayPID_NOTCH_PATHWAY

SSPOP NOTCH1 NOTCH4

2.88e-0459313M17
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH1 NOTCH4

3.05e-0412312M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH4

3.05e-0412312M47533
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH4

3.60e-0413312M47423
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH1 NOTCH4

3.60e-0413312M47534
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LAMC1 LTBP1 FBN2 LTBP4 COL1A1

4.55e-04300315M610
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH4

5.51e-0416312M47424
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH4

7.01e-0418312M614
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

NOTCH1 NOTCH4

8.68e-0420312M27881
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH1 NOTCH4

1.15e-0323312MM14954
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

NOTCH1 NOTCH4

1.25e-0324312M11190
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

LTBP1 FBN2

1.36e-0325312M39713
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

NOTCH1 NOTCH4

1.59e-0327312M39545
PathwayREACTOME_TRP_CHANNELS

TRPM6 TRPV4

1.71e-0328312MM14943
PathwayREACTOME_TRP_CHANNELS

TRPM6 TRPV4

1.71e-0328312M27241
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH1 NOTCH4

1.71e-0328312M6177
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC19 ADAMTS20 SSPOP

1.73e-03109313MM15164
PathwayWP_1Q211_COPY_NUMBER_VARIATION_SYNDROME

NBPF12 PYGO1

1.83e-0329312M39890
PathwayREACTOME_MET_ACTIVATES_PTK2_SIGNALING

LAMC1 COL1A1

1.96e-0330312M27772
PathwayWP_INFLAMMATORY_RESPONSE_PATHWAY

LAMC1 COL1A1

1.96e-0330312M39641
PathwayWP_INFLAMMATORY_RESPONSE_PATHWAY

LAMC1 COL1A1

1.96e-0330312MM15812
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS20 SSPOP NOTCH1 NOTCH4

2.08e-03250314M27554
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

BMPR2 NOTCH1 NOTCH4

2.17e-03118313M39852
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

BMPR2 LTBP1 LTBP4

2.17e-03118313MM15588
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LTBP1 FBN2 LTBP4 COL1A1

2.34e-03258314MM14572
PathwayWP_OSX_AND_MIRNAS_IN_TOOTH_DEVELOPMENT

NOTCH1 NOTCH4

2.51e-0334312M39390
PathwayKEGG_PRION_DISEASES

LAMC1 NOTCH1

2.66e-0335312M13036
PathwayWP_NEOVASCULARIZATION_PROCESSES

NOTCH1 NOTCH4

2.97e-0337312M39506
PathwayWP_GENETIC_CAUSES_OF_PORTOSINUSOIDAL_VASCULAR_DISEASE

NOTCH1 NOTCH4

2.97e-0337312M45513
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP1 LTBP4

3.13e-0338312MM14874
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS20 SSPOP

3.30e-0339312M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS20 SSPOP

3.30e-0339312MM15165
PathwayREACTOME_SIGNALING_BY_NOTCH

NOTCH1 NOTCH4

3.30e-0339312MM14604
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

LAMC1 FBN2 COL1A1

3.52e-03140313M587
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

LAMC1 COL1A1

3.64e-0341312M27778
PathwayPID_INTEGRIN3_PATHWAY

LAMC1 COL1A1

4.00e-0343312M53
PathwayWP_NOTCH_SIGNALING_WP268

NOTCH1 NOTCH4

4.37e-0345312M39571
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

ZNF462 BMPR2 TRIM5

4.51e-03153313M39546
PathwayPID_PS1_PATHWAY

SSPOP NOTCH1

4.56e-0346312M70
PathwayWP_HEART_DEVELOPMENT

BMPR2 NOTCH1

4.56e-0346312MM15884
PathwayWP_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH4

4.56e-0346312MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH4

4.76e-0347312M7946
PathwayWP_HEART_DEVELOPMENT

BMPR2 NOTCH1

4.76e-0347312M39610
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP1 LTBP4

4.76e-0347312M646
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

BMPR2 LTBP1 LTBP4

5.20e-03161313M27871
PathwayPID_TAP63_PATHWAY

SSPOP DICER1

6.24e-0354312M256
PathwayWP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES

DICER1 NOTCH1

6.93e-0357312M39877
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMC1 COL1A1

7.41e-0359312M27218
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

LTBP1 FBN2 LTBP4

7.55e-09444312429738
Pubmed

A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.

NBPF10 NBPF19 NBPF12 NBPF20

1.31e-082144416079250
Pubmed

Jagged1 is essential for osteoblast development during maxillary ossification.

BMPR2 NOTCH1 NOTCH4 COL1A1

1.60e-082244424491691
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

LAMC1 LTBP1 FBN2 SSPOP LTBP4 COL1A1

8.97e-0817544628071719
Pubmed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

LAMC1 LTBP1 FBN2 LTBP4 COL1A1

7.87e-0713544528675934
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

ADAMTS20 LAMC1 SSPOP COL1A1

1.34e-066444422261194
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

LAMC1 FBN2 COL1A1

1.52e-061844339040056
Pubmed

Introduction to Notch signaling.

NOTCH1 NOTCH4

1.56e-06244225053477
Pubmed

Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation.

NOTCH1 NOTCH4

1.56e-06244224305720
Pubmed

Notch signaling in cancer.

NOTCH1 NOTCH4

1.56e-06244212496471
Pubmed

Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.

NOTCH1 NOTCH4

1.56e-06244223389453
Pubmed

Notch signaling: from the outside in.

NOTCH1 NOTCH4

1.56e-06244211112321
Pubmed

Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma.

NOTCH1 NOTCH4

1.56e-06244225031748
Pubmed

Thymosin beta4 induces angiogenesis through Notch signaling in endothelial cells.

NOTCH1 NOTCH4

1.56e-06244223749167
Pubmed

Critical role of endothelial Notch1 signaling in postnatal angiogenesis.

NOTCH1 NOTCH4

1.56e-06244217158336
Pubmed

Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes.

BMPR2 NOTCH1

1.56e-06244230582451
Pubmed

Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer.

NOTCH1 NOTCH4

1.56e-06244222084425
Pubmed

Notch-1 and notch-4 receptors as prognostic markers in breast cancer.

NOTCH1 NOTCH4

1.56e-06244220444726
Pubmed

Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma.

NOTCH1 NOTCH4

1.56e-06244223742774
Pubmed

Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma.

NOTCH1 NOTCH4

1.56e-06244226530164
Pubmed

Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1.

TRPV4 COL1A1

1.56e-06244224559391
Pubmed

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development.

BMPR2 FBN2 NOTCH1 COL1A1

2.15e-067244437702066
Pubmed

Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.

BMPR2 NOTCH1 COL1A1

3.75e-062444325382630
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH1 NOTCH4

4.69e-06344225846406
Pubmed

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.

NOTCH1 NOTCH4

4.69e-06344218593923
Pubmed

Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma.

NOTCH1 NOTCH4

4.69e-06344226341090
Pubmed

Differential expression of Notch genes in human osteoblastic cells.

NOTCH1 NOTCH4

4.69e-06344211836628
Pubmed

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.

NOTCH1 NOTCH4

4.69e-06344214988227
Pubmed

Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues.

NOTCH1 NOTCH4

4.69e-06344222066479
Pubmed

Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation.

NOTCH1 NOTCH4

4.69e-06344215939383
Pubmed

Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease.

NOTCH1 NOTCH4

4.69e-06344219546852
Pubmed

NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.

NOTCH1 NOTCH4

4.69e-06344221679465
Pubmed

Notch signaling: cell fate control and signal integration in development.

NOTCH1 NOTCH4

4.69e-06344210221902
Pubmed

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

NOTCH1 NOTCH4

4.69e-06344228871079
Pubmed

Notch1 is pan-endothelial at the onset of flow and regulated by flow.

NOTCH1 NOTCH4

4.69e-06344225830332
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

LAMC1 FBN2 COL1A1

4.81e-062644334189436
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

TRPV4 NOTCH1 NOTCH4

6.75e-062944325535917
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

LTBP1 FBN2 COL1A1

7.49e-063044332882513
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

LAMC1 LTBP1 LTBP4 COL1A1

8.32e-0610144420551380
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH1 NOTCH4

9.37e-06444228061457
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH1 NOTCH4

9.37e-06444224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH1 NOTCH4

9.37e-06444220069356
Pubmed

ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.

NOTCH1 NOTCH4

9.37e-06444227354212
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH1 NOTCH4

9.37e-06444219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH1 NOTCH4

9.37e-06444228669409
Pubmed

Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability.

LTBP1 LTBP4

9.37e-06444215611103
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH1 NOTCH4

9.37e-06444211466531
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH1 NOTCH4

9.37e-06444224151014
Pubmed

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

NOTCH1 NOTCH4

9.37e-06444217984306
Pubmed

An expanded clade of rodent Trim5 genes.

TRIM6 TRIM5

9.37e-06444219147168
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH1 NOTCH4

9.37e-06444211401408
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH1 NOTCH4

9.37e-06444210194420
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH1 NOTCH4

9.37e-0644428898100
Pubmed

Antiretroviral potential of human tripartite motif-5 and related proteins.

TRIM6 TRIM5

9.37e-06444216828831
Pubmed

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.

NOTCH1 NOTCH4

9.37e-06444236376768
Pubmed

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

NOTCH1 NOTCH4

9.37e-06444211459941
Pubmed

Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages.

NOTCH1 NOTCH4

9.37e-06444220739676
Pubmed

Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.

TRIM6 TRIM5

9.37e-06444221680743
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH1 NOTCH4

9.37e-06444218184405
Pubmed

The latent transforming growth factor beta binding protein (LTBP) family.

LTBP1 LTBP4

9.37e-06444211104663
Pubmed

Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.

NOTCH1 NOTCH4

9.37e-06444235543859
Pubmed

Notch signaling in the mammalian central nervous system: insights from mouse mutants.

NOTCH1 NOTCH4

9.37e-06444215917835
Pubmed

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

NOTCH1 NOTCH4

9.37e-06444223444212
Pubmed

Deregulated expression of Notch receptors in human hepatocellular carcinoma.

NOTCH1 NOTCH4

9.37e-06444217920003
Pubmed

Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.

LTBP1 LTBP4

9.37e-06444216157329
Pubmed

RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.

BMPR2 LTBP1 COL1A1

1.20e-053544332281291
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

ADAMTS20 BMPR2 COL1A1

1.31e-053644325615642
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

LTBP1 TIMP4 LTBP4

1.31e-053644320587546
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

LAMC1 FBN2 COL1A1

1.42e-053744334323105
Pubmed

Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm.

LTBP1 LTBP4

1.56e-05544219897194
Pubmed

Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.

NOTCH1 NOTCH4

1.56e-05544221124806
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

NOTCH1 NOTCH4

1.56e-05544223675950
Pubmed

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

NOTCH1 NOTCH4

1.56e-05544211101851
Pubmed

Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy.

DICER1 COL1A1

1.56e-05544222113163
Pubmed

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

NOTCH1 NOTCH4

1.56e-05544215882997
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

LTBP1 FBN2

1.56e-05544234411563
Pubmed

Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.

NOTCH1 NOTCH4

1.56e-05544227118257
Pubmed

Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.

NOTCH1 NOTCH4

1.56e-05544220554499
Pubmed

RBP-L, a transcription factor related to RBP-Jkappa.

NOTCH1 NOTCH4

2.34e-0564429111338
Pubmed

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

NOTCH1 NOTCH4

2.34e-05644220870902
Pubmed

A study on Notch signaling in human breast cancer.

NOTCH1 NOTCH4

2.34e-05644217822320
Pubmed

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

LTBP1 LTBP4

2.34e-05644219349279
Pubmed

Characterization of Notch receptor expression in the developing mammalian heart and liver.

NOTCH1 NOTCH4

2.34e-05644212244553
Pubmed

Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.

TRIM6 TRIM5

2.34e-05644216775307
Pubmed

Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.

NOTCH1 NOTCH4

2.34e-05644218239137
Pubmed

Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.

NOTCH1 NOTCH4

2.34e-05644229228365
Pubmed

Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.

NOTCH1 NOTCH4

2.34e-05644219503073
Pubmed

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

NOTCH1 NOTCH4

2.34e-0564427835890
Pubmed

Nidogen-2: a new basement membrane protein with diverse binding properties.

LAMC1 COL1A1

2.34e-0564429733643
Pubmed

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

NOTCH1 NOTCH4

2.34e-05644218299578
Pubmed

Notch4 reveals a novel mechanism regulating Notch signal transduction.

NOTCH1 NOTCH4

2.34e-05644224667410
Pubmed

Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.

NOTCH1 NOTCH4

2.34e-05644215019995
Pubmed

Notch controls the magnitude of T helper cell responses by promoting cellular longevity.

NOTCH1 NOTCH4

2.34e-05644222615412
Pubmed

Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.

NOTCH1 NOTCH4

2.34e-05644221991352
Pubmed

TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway.

DICER1 NOTCH1

2.34e-05644228174252
Pubmed

Human ligands of the Notch receptor.

NOTCH1 NOTCH4

3.27e-05744210079256
Pubmed

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.

NOTCH1 NOTCH4

3.27e-05744218952909
Pubmed

Notch signaling functions in lymphatic valve formation.

NOTCH1 NOTCH4

3.27e-05744224917500
Pubmed

Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.

LTBP1 LTBP4

3.27e-05744219998449
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

NOTCH1 NOTCH4

3.27e-05744212846471
InteractionNTN5 interactions

LTBP1 FBN2 LTBP4 NOTCH1

1.85e-0724434int:NTN5
InteractionFOXD4L6 interactions

FBN2 LTBP4 DICER1 NOTCH1

3.55e-0649434int:FOXD4L6
InteractionDLL4 interactions

NOTCH1 NOTCH4

6.63e-056432int:DLL4
CytobandEnsembl 112 genes in cytogenetic band chr1q21

NBPF10 NBPF19 NBPF12 NBPF20

6.07e-04404444chr1q21
Cytoband12q12

MUC19 ADAMTS20

9.44e-044744212q12
CytobandEnsembl 112 genes in cytogenetic band chr12q12

MUC19 ADAMTS20

1.69e-0363442chr12q12
GeneFamilyNeuroblastoma breakpoint family

NBPF10 NBPF19 NBPF12 NBPF20

1.14e-0723364662
GeneFamilyLatent transforming growth factor beta binding proteins

LTBP1 LTBP4

2.31e-054362628
GeneFamilyTransient receptor potential cation channels

TRPM6 TRPV4

1.41e-0328362249
GeneFamilyCD molecules|Complement system|LY6/PLAUR domain containing

LYPD3 LYPD2

2.08e-03343621226
GeneFamilyAnkyrin repeat domain containing

TRPV4 NOTCH1 NOTCH4

1.22e-02242363403
GeneFamilyPHD finger proteins

PHF7 PYGO1

1.38e-029036288
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM6 TRIM5

1.53e-029536259
GeneFamilyRing finger proteins

TRIM6 TRIM5 RBCK1

1.72e-0227536358
GeneFamilyKeratin associated proteins

KRTAP24-1 KRTAP3-1

1.99e-02109362619
CoexpressionNABA_MATRISOME

MUC19 ADAMTS20 VWC2 LAMC1 LTBP1 FBN2 TIMP4 SSPOP LTBP4 COL1A1

5.10e-0610084410MM17056
CoexpressionNABA_CORE_MATRISOME

LAMC1 LTBP1 FBN2 SSPOP LTBP4 COL1A1

5.74e-06270446MM17057
CoexpressionNABA_MATRISOME

MUC19 ADAMTS20 VWC2 LAMC1 LTBP1 FBN2 TIMP4 SSPOP LTBP4 COL1A1

5.96e-0610264410M5889
CoexpressionNABA_CORE_MATRISOME

LAMC1 LTBP1 FBN2 SSPOP LTBP4 COL1A1

6.38e-06275446M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMC1 LTBP1 FBN2 SSPOP LTBP4

1.68e-05191445MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMC1 LTBP1 FBN2 SSPOP LTBP4

1.90e-05196445M3008
CoexpressionGSE7568_CTRL_VS_24H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN

ZNF462 LAMC1 TRPV4 IGSF9 HCN1

2.10e-05200445M364
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#4_top-relative-expression-ranked_1000

ADAMTS20 VWC2 LTBP1 FBN2 COL1A1

3.55e-05195415gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000_k4
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

LAMC1 LTBP1 LTBP4 COL1A1

3.64e-0597414GSM777043_100
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 VWC2 TRPV4 PTPRH

1.20e-05143444990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LYPD2 IGSF9 MED13 NBPF20

2.06e-051644441aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|367C / Donor, Lineage, Cell class and subclass (all cells)

LYPD2 IGSF9 MED13 NBPF20

2.16e-05166444430d604f5bef9fae20dc81492e6695616f6701a3
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 IGSF9 TRIM6 PTPRH

2.27e-0516844403896466698a79f7f1ad862cb7e05585260e2a5a
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LYPD2 LTBP1 LTBP4 COL1A1

2.60e-05174444a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|390C / Donor, Lineage, Cell class and subclass (all cells)

LTBP1 CCDC168 FBN2 COL1A1

2.72e-05176444852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|390C / Donor, Lineage, Cell class and subclass (all cells)

LTBP1 CCDC168 FBN2 COL1A1

2.72e-05176444d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LYPD2 TRPV4 FBN2 DOK7

2.84e-05178444fb8f8d95f6b08378fb42c4076ee040276faa296f
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LYPD2 TRPV4 FBN2 DOK7

2.84e-05178444b89c4d015b44bf538aa39969ef8778877c8023f1
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYPD2 TRPV4 FBN2 DOK7

3.17e-05183444ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCellfacs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYPD2 TRPV4 FBN2 DOK7

3.17e-05183444f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 TIMP4 LTBP4 COL1A1

3.37e-05186444d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

LTBP1 FBN2 LTBP4 COL1A1

3.44e-051874445258674d0346e5c51a4b965efcdc1790c970845d
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 TIMP4 LTBP4 COL1A1

3.44e-051874446f47a80e612b320f571210483e62ff5db2a8ea43
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 LAMC1 LTBP4 COL1A1

3.44e-05187444976b74d081b7fba8620768613cc26f9262cd7b16
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MUC19 LYPD2 NOTCH1 NOTCH4

3.52e-05188444366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 LAMC1 LTBP4 COL1A1

3.59e-051894446b3b42d758b63a0df62310c34fa3bde421c1afd7
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMC1 LTBP1 LTBP4 COL1A1

3.59e-05189444d531399749409d614adca13d181830c6e3287508
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 LAMC1 LTBP4 COL1A1

3.59e-05189444344b23d3c47d0665dda1cd4856a5e72f1c28cfb3
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 ADAMTS20 LTBP1 FBN2

3.67e-051904442f54da2bee411f8868348a4c37034184b8f58a89
ToppCellMatrixFB-Fibroblast-C|MatrixFB / shred on cell class and cell subclass (v4)

LYPD2 FBN2 LTBP4 COL1A1

3.67e-05190444d0106f7a21292f0b96ce4337ec3efbb1bd78dd0a
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWC2 FBN2 LTBP4 COL1A1

3.67e-05190444947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.74e-05191444d04e6292fef189b8d8ed0f4b0c310b2b250fd30e
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRPV4 LTBP1 LTBP4 NOTCH1

3.74e-05191444b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.74e-05191444094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.74e-05191444ce80f65bd24b1c4d2152bf45248449e7a1a97e56
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 TIMP4 LTBP4 NOTCH4

3.74e-05191444b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.74e-05191444997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.74e-05191444ba02cbdfda6a94374a6472eb88499059979af472
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 FBN2 LTBP4 COL1A1

3.82e-05192444ac1477433704573f95111eee6263b93668d2845e
ToppCelldroplet-Lung-1m-Mesenchymal|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.82e-0519244401433bd4794b8bcc51fe4249124a0f4289b9d6e2
ToppCellfacs-Lung-3m-Mesenchymal|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.82e-051924448df15085b35b86f39debd933284cb703c5dd63c2
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.82e-0519244432acd89617934016cd135d2cc797e8e79ae1b37f
ToppCellwk_08-11-Mesenchymal-Fibroblast-Mesenchymal_3|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

VWC2 PLPPR3 HCN1 COL1A1

3.82e-05192444d88753b200d9c8da6716222d697ddf0a1548d6c8
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.82e-05192444321850b0f881420c2d57d3e825e365c82fa511ab
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 FBN2 LTBP4 COL1A1

3.82e-051924448937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.82e-05192444cf2765d8bc074f7f9ee864eae632a3b705175842
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.82e-051924447b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 FBN2 LTBP4 COL1A1

3.82e-05192444e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF462 BMPR2 LTBP4 NOTCH1

3.90e-05193444826b8dd801298b3e0cd76232feae5a14026b8806
ToppCellfacs-MAT-Fat-24m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYPD3 TIMP4 NOTCH1 NOTCH4

3.90e-05193444ba9a47e2dc01efa6d2a99b1631d4951fac2648d4
ToppCellIPF-Endothelial-VE_Arterial|World / Disease state, Lineage and Cell class

LYPD2 LTBP1 LTBP4 NOTCH4

3.90e-0519344470a9aadda83a97e06e9bc2d1327ce60dd3c58767
ToppCellfacs-MAT-Fat-24m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYPD3 TIMP4 NOTCH1 NOTCH4

3.90e-05193444724bb613fa434add5b1c5586b629328f819fbdfe
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF462 BMPR2 LTBP4 NOTCH1

3.90e-0519344487d3a577d37fb0cb4b6313c596310de452bc3872
ToppCellfacs-MAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.90e-05193444733f557bdc80293b40ccdf560f1675793df932d6
ToppCellfacs-MAT-Fat-24m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.90e-05193444eb3c46b6fb06dc8708dc3032189b47ed93ee2357
ToppCellIPF-Endothelial-VE_Arterial|IPF / Disease state, Lineage and Cell class

LYPD2 LTBP1 LTBP4 NOTCH4

3.90e-05193444bf83b1fe9d38408f30eee4eb634341c04ef82791
ToppCellfacs-MAT-Fat-24m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYPD3 TIMP4 NOTCH1 NOTCH4

3.90e-05193444737e540c72a3cfe8dbd4c0f139f7d729a166793a
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.90e-05193444d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellfacs-MAT-Fat-24m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.90e-05193444b45cd02081f97904eaea2d013e1fa980505d060b
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-mesenchymal_progenitor_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-051944443d25d6ebec8d1b6001f602257cd15b3ba04cf0c1
ToppCellfacs-GAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-051944449709dc95fb6982b6a0467b507845d5bc17252e3e
ToppCellfacs-GAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-0519444493b7a9065430740ec31fce4e8c14ffccb498591d
ToppCellfacs-MAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-05194444f906b090f67df4cfe3498cdbb52cc0efa08e06cc
ToppCellfacs-GAT-Fat-18m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-051944440d2e65b44e3f143971c2fd24c4552f042b049cfa
ToppCellfacs-MAT-Fat-18m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-05194444944cdb0403d80a10a2eea2a3516a9343dbccc32c
ToppCellfacs-MAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-0519444485081d255fcc1e9854c0073321dd9f0feaa48866
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

3.98e-05194444ff19fb5bc7feae3e774ef4ab720beb9dec219f45
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.06e-0519544469a29d03e664b72f32d41876510c62345c3aed31
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LTBP1 LTBP4 COL1A1

4.06e-05195444edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCellfacs-Heart-LA-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.06e-0519544479a6e8e6de040ff07539e8901fc407363a50e355
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMC1 LTBP1 LTBP4 COL1A1

4.06e-051954441236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMC1 LTBP1 LTBP4 COL1A1

4.06e-05195444f54bc4454270ff06e85596f98199372b50d0179f
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.06e-051954441cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.06e-051954449cef6f18664518060af7c192310dddce6d70345a
ToppCellCOPD-Stromal-Myofibroblast|COPD / Disease state, Lineage and Cell class

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-05196444af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCellfacs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-05196444ad1838dabd043cb140260843e3527d8c7d58850e
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-05196444d4676a6b0d9e417795fc9a6bcb1762d3dd656ca9
ToppCellIPF-Stromal-Fibroblast|IPF / Disease state, Lineage and Cell class

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-05196444f7ae604ba32b322d86d68b2b54892e7c6ab06c49
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-05196444b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TIMP4 LTBP4 NOTCH1 NOTCH4

4.14e-05196444a20a56d8997d6db2a10046c8801c619a379de83c
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-05196444787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-051964447d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellfacs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.14e-05196444cbc15c0769016fe9972445169029bd8d14a7e6ef
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC1 LTBP1 LTBP4 COL1A1

4.22e-0519744485a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellCOPD-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

LAMC1 LTBP1 LTBP4 COL1A1

4.22e-05197444d51f484b4e01ac64233950d0b97fa88825ea1dbb
ToppCellCOPD-Stromal|COPD / Disease state, Lineage and Cell class

LAMC1 LTBP1 LTBP4 COL1A1

4.22e-05197444d5390d86acaa8c39f1da893e8d2271f9ed2951d7
ToppCellfacs-Heart-LA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.22e-051974442a91738cb6d7588869dd00deeea0cbbc2d6aa34d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC1 LTBP1 LTBP4 COL1A1

4.22e-05197444e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BMPR2 LTBP1 LTBP4 NOTCH4

4.22e-0519744456afed433887cb2766eb30f22aec195148db33ab
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 TIMP4 LTBP4 COL1A1

4.30e-0519844438b37daf41d84e5bf913eb3f72963418b7c0aac6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BMPR2 LTBP1 LTBP4 NOTCH4

4.30e-051984445e781583908c4ee107d986904a646a7c6b8e3591
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMC1 LTBP1 LTBP4 COL1A1

4.30e-051984448f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR2 LTBP1 LTBP4 NOTCH4

4.30e-051984449e103228ac2cc86eec58bc6b8e142965228e8853
ToppCellIPF-Stromal|IPF / Disease state, Lineage and Cell class

LAMC1 LTBP1 LTBP4 COL1A1

4.30e-05198444ece914c32c9b123b779aa9624b92e6230763a20e
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LTBP1 FBN2 LTBP4 COL1A1

4.30e-051984447a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP1 LTBP4 COL1A1

4.30e-051984440dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMPR2 LTBP1 LTBP4 NOTCH4

4.30e-0519844412697db1e516c2afdb5fa1ca8caa06f4abed3382
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAMC1 LTBP1 LTBP4 COL1A1

4.39e-05199444e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMC1 LTBP1 LTBP4 COL1A1

4.39e-051994440019cfaa586a450c2e4952d1184a540561c8d0ba
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 FBN2 LTBP4 COL1A1

4.39e-0519944430ab0750d51f168b18c434c974d24a4e70f29cc7
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 FBN2 LTBP4 COL1A1

4.39e-0519944484545ced0c792bc77980a50d65e484eab648d47e
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 FBN2 LTBP4 COL1A1

4.39e-0519944436c1deac7ef0f9ebde6b2f7a63f7daa03d8c139a
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LAMC1 LTBP1 LTBP4 COL1A1

4.39e-0519944430d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellILEUM-non-inflamed-(8)_Smooth_muscle_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

LAMC1 LTBP1 LTBP4 COL1A1

4.39e-051994443368c0a90a47c4dcdfe70be3192550df0744e508
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LAMC1 LTBP1 LTBP4 COL1A1

4.39e-05199444e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 FBN2 LTBP4 COL1A1

4.39e-05199444e78f661b40da34768469549b6e755d330be6bbd8
ToppCellParenchymal-10x3prime_v2-Stromal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LAMC1 LTBP1 LTBP4 COL1A1

4.48e-05200444f6be0f24e607abb9007823a54fb0b24d04990a89
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LAMC1 LTBP1 LTBP4 COL1A1

4.48e-052004449b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellcellseq-Mesenchymal-Fibroblastic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMC1 LTBP1 LTBP4 COL1A1

4.48e-052004448978867bf69c830b1e48cac2ad6b512dbe60f149
Diseaseendometrial cancer (is_marker_for)

TIMP4 NOTCH1 NOTCH4

1.47e-0535403DOID:1380 (is_marker_for)
DiseaseAutistic behavior

ZNF462 MED13

4.99e-058402C0856975
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN2 NOTCH1 COL1A1

5.16e-0553403C4707243
Diseasehemangiopericytoma (is_marker_for)

NOTCH1 NOTCH4

6.41e-059402DOID:264 (is_marker_for)
Diseasethyroid peroxidase antibody measurement

TRPM6 TMEM131L DICER1

1.29e-0472403EFO_0005666
Diseasepulmonary hypertension (biomarker_via_orthology)

TRPV4 BMPR2 COL1A1

1.76e-0480403DOID:6432 (biomarker_via_orthology)
Diseaseobesity (implicated_via_orthology)

ADAMTS20 MED13 NOTCH1 NOTCH4

2.04e-04215404DOID:9970 (implicated_via_orthology)
Diseaseresponse to mitochondrial complex I inhibitor

VWC2 LTBP4

3.02e-0419402EFO_0600033
DiseaseCarcinoma, Pancreatic Ductal

NOTCH1 NOTCH4

4.85e-0424402C0887833
DiseaseHeart valve disease

NOTCH1 COL1A1

5.70e-0426402C0018824
Diseasecentral corneal thickness

ADAMTS20 LTBP1 FBN2 COL1A1

8.01e-04309404EFO_0005213
Diseasebrain measurement, neuroimaging measurement

ZNF462 ADAMTS20 LAMC1 IGSF9 FBN2

8.48e-04550405EFO_0004346, EFO_0004464
Diseasephosphatidylcholine 38:5 measurement

DICER1 DOK7

9.21e-0433402EFO_0010387
DiseaseAlzheimer disease, polygenic risk score

MUC19 VWC2 TRPV4 PLPPR3 HCN1

1.13e-03586405EFO_0030082, MONDO_0004975
Diseasesphingolipid measurement

DOK7 NOTCH4

1.35e-0340402EFO_0004622

Protein segments in the cluster

PeptideGeneStartEntry
GQTCVAPDYVLCSPE

ALDH3B1

241

P43353
ADYTQDPSVTPCCNP

ARSG

501

Q96EG1
YTSQPCEIVVDCGPF

DICER1

246

Q9UPY3
PPCNYIVVTADSSQC

ADAMTS20

1586

P59510
PCYNQGTCEPTSESP

NOTCH1

1396

P46531
NTEPAECPVCYSVLA

RBCK1

276

Q9BYM8
NLTTYVQPGCESPCE

KRTAP3-1

81

Q9BYR8
STCPDEQCVNSPGSY

LTBP1

1006

Q14766
CPCESSGTVYQPGEV

MUC19

776

Q7Z5P9
YVCPEPTGVSDCVTI

LYPD2

26

Q6UXB3
CQGTSPPVVSCYNAS

LYPD3

151

O95274
PCSYTTAVCSPPVQS

HCN1

696

O60741
SQGCPSTEVYNPETD

KLHL15

506

Q96M94
PQECHYEECVVTTTP

BMPR2

91

Q13873
QQCPGTETAEYQSLC

LTBP4

1221

Q8N2S1
TNTCGTPPEEYCVQT

LAMC1

66

P11047
PSCSPSTQTNGYVCN

KRTAP24-1

116

Q3LI83
TSPETFNYCTPVLSC

CCDC168

1331

Q8NDH2
CTCLPGTVEYQVPTS

DOK7

386

Q18PE1
PNGRYCTDVDECQTP

FBN2

651

P35556
SSDPVYPCGICTNEV

PYGO1

336

Q9Y3Y4
CLTCQGTGYIPTEQV

TMEM106C

51

Q9BVX2
PCPVTNCTAIEGAEY

SSPOP

3306

A2VEC9
QSDVYENCCPINPTT

TMEM131L

1541

A2VDJ0
SSCLEQPDSCQPYGS

NBPF10

1526

Q6P3W6
YSTPSSCLEQPDSCQ

NBPF10

1766

Q6P3W6
SCLEQPDSCQPYGSS

NBPF10

1771

Q6P3W6
SSCLEQPDSCQPYGS

NBPF10

2746

Q6P3W6
YSTPSSCLEQPDSCQ

NBPF10

2986

Q6P3W6
SCLEQPDSCQPYGSS

NBPF10

2991

Q6P3W6
YSTPSSCLEQPDSCQ

NBPF12

1061

Q5TAG4
SSCLEQPDSCQPYGS

NBPF19

1011

A0A087WUL8
YSTPSSCLEQPDSCQ

NBPF19

1251

A0A087WUL8
SCLEQPDSCQPYGSS

NBPF19

1256

A0A087WUL8
SSCLEQPDSCQPYGS

NBPF19

2231

A0A087WUL8
YSTPSSCLEQPDSCQ

NBPF19

2471

A0A087WUL8
SCLEQPDSCQPYGSS

NBPF19

2476

A0A087WUL8
SSCLEQPDSCQPYGS

NBPF19

3451

A0A087WUL8
YSTPSSCLEQPDSCQ

NBPF19

3691

A0A087WUL8
SCLEQPDSCQPYGSS

NBPF19

3696

A0A087WUL8
SSCLEQPDSCQPYGS

NBPF20

911

P0DPF2
YSTPSSCLEQPDSCQ

NBPF20

1151

P0DPF2
SCLEQPDSCQPYGSS

NBPF20

1156

P0DPF2
SSCLEQPDSCQPYGS

NBPF20

2131

P0DPF2
YSTPSSCLEQPDSCQ

NBPF20

2371

P0DPF2
SCLEQPDSCQPYGSS

NBPF20

2376

P0DPF2
SSCLEQPDSCQPYGS

NBPF20

3351

P0DPF2
YSTPSSCLEQPDSCQ

NBPF20

3591

P0DPF2
SCLEQPDSCQPYGSS

NBPF20

3596

P0DPF2
SSCLEQPDSCQPYGS

NBPF20

4496

P0DPF2
YSTPSSCLEQPDSCQ

NBPF20

4811

P0DPF2
SCLEQPDSCQPYGSS

NBPF20

4816

P0DPF2
TDYIPENSGDIPCCS

PHF7

306

Q9BWX1
SSPCQPIYECELASQ

FYB2

236

Q5VWT5
IPDPTQEAQYRCTCG

MED13

1111

Q9UHV7
GPQCQTSTDYCVSAP

NOTCH4

761

Q99466
CNMETGETCVYPTQP

COL1A1

1291

P02452
GESSCPVCRISYQPE

TRIM5

51

Q9C035
VSACPQTECVDPVYE

VWC2

251

Q2TAL6
YAGEIDVCSSQPSCP

TRPM6

1026

Q9BX84
SCEVNPYITQDICSG

PLPPR3

176

Q6T4P5
TTCYTVPCTISAPNE

TIMP4

161

Q99727
TQPDDAGCYTCVPSN

IGSF9

291

Q9P2J2
GSTSQYCVTDPCSAP

XP32

151

Q5T750
ANPAISSTPYQCTVC

ZNF462

1461

Q96JM2
PDGTDPQNSTYCVQC

PTPRH

231

Q9HD43
NEDQTNCTVPTYPSC

TRPV4

646

Q9HBA0
PATFSPDVNVTCQTC

ZPBP2

301

Q6X784
EGERSCPVCQTSYQP

TRIM6

51

Q9C030