Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	3.98e-05	4	52	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR2 RYR3	9.91e-05	6	52	2	GO:0048763
Domain	Ryanrecept_TM4-6	RYR2 RYR3	2.02e-05	3	49	2	IPR009460
Domain	RyR	RYR2 RYR3	2.02e-05	3	49	2	PF02026
Domain	Ryanodine_rcpt	RYR2 RYR3	2.02e-05	3	49	2	IPR003032
Domain	RR_TM4-6	RYR2 RYR3	2.02e-05	3	49	2	PF06459
Domain	Ryan_recept	RYR2 RYR3	2.02e-05	3	49	2	IPR013333
Domain	EGF-like_dom	STAB2 FCGBP SUSD1 SCARF2 ADAM20 MASP2	4.57e-05	249	49	6	IPR000742
Domain	RIH_assoc	RYR2 RYR3	1.00e-04	6	49	2	PF08454
Domain	RIH_assoc-dom	RYR2 RYR3	1.00e-04	6	49	2	IPR013662
Domain	RIH_dom	RYR2 RYR3	1.00e-04	6	49	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3	1.00e-04	6	49	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	1.00e-04	6	49	2	IPR015925
Domain	-	RYR2 RYR3	1.00e-04	6	49	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3	1.00e-04	6	49	2	PF01365
Domain	Ins145_P3_rec	RYR2 RYR3	1.00e-04	6	49	2	PF08709
Domain	VWC	VWC2 FCGBP MUC2	1.34e-04	38	49	3	SM00214
Domain	VWF_dom	VWC2 FCGBP MUC2	1.81e-04	42	49	3	IPR001007
Domain	MIR	RYR2 RYR3	2.99e-04	10	49	2	PS50919
Domain	MIR	RYR2 RYR3	2.99e-04	10	49	2	PF02815
Domain	MIR	RYR2 RYR3	2.99e-04	10	49	2	SM00472
Domain	MIR_motif	RYR2 RYR3	2.99e-04	10	49	2	IPR016093
Domain	-	STAB2 SUSD1	3.65e-04	11	49	2	2.40.155.10
Domain	GFP-like	STAB2 SUSD1	3.65e-04	11	49	2	IPR023413
Domain	EGF_3	STAB2 SUSD1 SCARF2 ADAM20 MASP2	3.67e-04	235	49	5	PS50026
Domain	EGF	STAB2 FCGBP SUSD1 SCARF2 MASP2	3.67e-04	235	49	5	SM00181
Domain	TIL	FCGBP MUC2	4.38e-04	12	49	2	PF01826
Domain	C8	FCGBP MUC2	4.38e-04	12	49	2	PF08742
Domain	Unchr_dom_Cys-rich	FCGBP MUC2	5.16e-04	13	49	2	IPR014853
Domain	C8	FCGBP MUC2	5.16e-04	13	49	2	SM00832
Domain	OTU	OTUD4 VCPIP1	5.16e-04	13	49	2	PF02338
Domain	EGF_1	STAB2 SUSD1 SCARF2 ADAM20 MASP2	5.33e-04	255	49	5	PS00022
Domain	EGF-like_CS	STAB2 SUSD1 SCARF2 ADAM20 MASP2	5.92e-04	261	49	5	IPR013032
Domain	TIL_dom	FCGBP MUC2	6.01e-04	14	49	2	IPR002919
Domain	EGF_2	STAB2 SUSD1 SCARF2 ADAM20 MASP2	6.34e-04	265	49	5	PS01186
Domain	OTU	OTUD4 VCPIP1	6.93e-04	15	49	2	PS50802
Domain	OTU_dom	OTUD4 VCPIP1	6.93e-04	15	49	2	IPR003323
Domain	Growth_fac_rcpt_	STAB2 SUSD1 SCARF2 RSPO4	7.41e-04	156	49	4	IPR009030
Domain	VWD	FCGBP MUC2	7.90e-04	16	49	2	SM00216
Domain	VWF_type-D	FCGBP MUC2	7.90e-04	16	49	2	IPR001846
Domain	VWFD	FCGBP MUC2	7.90e-04	16	49	2	PS51233
Domain	VWD	FCGBP MUC2	7.90e-04	16	49	2	PF00094
Domain	VWC_out	FCGBP MUC2	1.12e-03	19	49	2	SM00215
Domain	PHD	DIDO1 UBR7 RAI1	1.64e-03	89	49	3	SM00249
Domain	Znf_PHD	DIDO1 UBR7 RAI1	1.75e-03	91	49	3	IPR001965
Domain	ZF_PHD_2	DIDO1 UBR7 RAI1	1.98e-03	95	49	3	PS50016
Domain	ZF_PHD_1	DIDO1 UBR7 RAI1	2.04e-03	96	49	3	PS01359
Domain	EGF_Lam	STAB2 SCARF2	3.80e-03	35	49	2	SM00180
Domain	VWFC_1	VWC2 MUC2	4.01e-03	36	49	2	PS01208
Domain	EGF_CA	STAB2 SUSD1 MASP2	4.02e-03	122	49	3	SM00179
Domain	EGF-like_Ca-bd_dom	STAB2 SUSD1 MASP2	4.21e-03	124	49	3	IPR001881
Domain	VWFC_2	VWC2 MUC2	4.46e-03	38	49	2	PS50184
Domain	Laminin_EGF	STAB2 SCARF2	4.46e-03	38	49	2	IPR002049
Domain	EF-hand_1	CAPN12 RYR2 RYR3	7.41e-03	152	49	3	PF00036
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	2.19e-06	2	52	2	14550562
Pubmed	The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.	FCGBP MUC2	2.19e-06	2	52	2	34126068
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	2.19e-06	2	52	2	21531043
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	2.19e-06	2	52	2	16678258
Pubmed	Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.	FCGBP MUC2	2.19e-06	2	52	2	19432394
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	2.19e-06	2	52	2	14985349
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	2.19e-06	2	52	2	8898078
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR2 RYR3	6.57e-06	3	52	2	9242641
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR2 RYR3	6.57e-06	3	52	2	18403125
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR2 RYR3	6.57e-06	3	52	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR2 RYR3	6.57e-06	3	52	2	10788707
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	6.57e-06	3	52	2	15024040
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR2 RYR3	6.57e-06	3	52	2	18434746
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	6.57e-06	3	52	2	29730765
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR2 RYR3	6.57e-06	3	52	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR2 RYR3	6.57e-06	3	52	2	7621815
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR2 RYR3	6.57e-06	3	52	2	9204703
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR2 RYR3	6.57e-06	3	52	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR2 RYR3	6.57e-06	3	52	2	11159936
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR2 RYR3	6.57e-06	3	52	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR2 RYR3	6.57e-06	3	52	2	21881589
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR2 RYR3	6.57e-06	3	52	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR2 RYR3	6.57e-06	3	52	2	7959768
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR2 RYR3	6.57e-06	3	52	2	12213830
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR2 RYR3	6.57e-06	3	52	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR2 RYR3	6.57e-06	3	52	2	7635066
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR2 RYR3	1.31e-05	4	52	2	9384575
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR2 RYR3	1.31e-05	4	52	2	18206662
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR2 RYR3	1.31e-05	4	52	2	9607712
Pubmed	Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes.	FCGBP MUC2	1.31e-05	4	52	2	28604600
Pubmed	SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.	PRMT5 SKI	1.31e-05	4	52	2	29227283
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR2 RYR3	1.31e-05	4	52	2	23482488
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR2 RYR3	1.31e-05	4	52	2	23413940
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	RYR2 RYR3	2.19e-05	5	52	2	33060591
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR2 RYR3	2.19e-05	5	52	2	19011160
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR2 RYR3	2.19e-05	5	52	2	23918386
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR2 RYR3	3.28e-05	6	52	2	19549818
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR2 RYR3	3.28e-05	6	52	2	19009018
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR2 RYR3	3.28e-05	6	52	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 RYR3	3.28e-05	6	52	2	23463619
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 RYR3	3.28e-05	6	52	2	16844763
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR2 RYR3	3.28e-05	6	52	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 RYR3	3.28e-05	6	52	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 RYR3	3.28e-05	6	52	2	25966694
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 RYR3	4.58e-05	7	52	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR2 RYR3	4.58e-05	7	52	2	20962236
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR2 RYR3	6.10e-05	8	52	2	11784029
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR2 RYR3	6.10e-05	8	52	2	19033399
Pubmed	Transcriptional analyses of two mouse models of spina bifida.	FKBP8 SKI	7.84e-05	9	52	2	23024056
Pubmed	Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.	NPC1 CLN5	7.84e-05	9	52	2	15647513
Pubmed	Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5.	PRMT5 SKI	9.79e-05	10	52	2	19032343
Pubmed	OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis.	PRMT5 OTUD4	1.20e-04	11	52	2	36411454
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR2 RYR3	1.43e-04	12	52	2	19095005
Pubmed	Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development.	COL12A1 ETV4	1.69e-04	13	52	2	15634692
Pubmed	Hereditary Dystonia Overview	NPC1 CLN5 PNKD	2.57e-04	82	52	3	20301334
Pubmed	New semidominant mutations that affect mouse development.	COL12A1 ETV4	2.60e-04	16	52	2	15384171
Pubmed	Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons.	HOXB6 ETV4	3.30e-04	18	52	2	23359544
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTUD4 VCPIP1	3.69e-04	19	52	2	23827681
Pubmed	Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.	ETV4 SKI	4.52e-04	21	52	2	23610558
Pubmed	Chromosomal localization of homeobox genes and associated markers on porcine chromosomes 3, 5, 12, 15, 16 and 18: comparative mapping study with human and mouse.	LHCGR HOXB6	5.93e-04	24	52	2	8833235
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	ERV3-1 PRMT5 DIDO1 RAI1	8.32e-04	281	52	4	24163370
Pubmed	Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.	SUSD1 MORN5	9.29e-04	30	52	2	20583170
Pubmed	Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.	ZFHX4 ETV4	1.06e-03	32	52	2	36596814
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	LHCGR RYR2 RYR3	1.30e-03	143	52	3	20424473
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR2 RYR3	1.49e-03	38	52	2	30786075
Pubmed	Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.	SUSD1 GP1BA	1.49e-03	38	52	2	16263699
Cytoband	12q23.3	SLC41A2 STAB2	7.31e-04	35	52	2	12q23.3
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	8.53e-06	3	31	2	287
GeneFamily	OTU domain containing	OTUD4 VCPIP1	3.81e-04	17	31	2	669
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	STAB2 SCARF2	9.72e-04	27	31	2	1253
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD1 MASP2	4.28e-03	57	31	2	1179
GeneFamily	EF-hand domain containing	CAPN12 RYR2 RYR3	6.14e-03	219	31	3	863
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 STAB2 ZFHX4 OTOGL RYR2 RYR3	7.51e-08	184	52	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 STAB2 ZFHX4 OTOGL RYR2 RYR3	7.51e-08	184	52	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 STAB2 ZFHX4 OTOGL RYR2 RYR3	7.51e-08	184	52	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ZFHX4 SAXO1 RYR2 RYR3	1.21e-06	160	52	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ZFHX4 SAXO1 RYR2 RYR3	1.21e-06	160	52	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 FCGBP RBPJL GNMT RYR2	1.25e-06	161	52	5	b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 FCGBP RBPJL GNMT RYR2	1.25e-06	161	52	5	f7a89c481f789f624102857be722c95fbeb47595
ToppCell	NS-moderate-d_07-13-Myeloid-Mast_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	VWC2 HOXB6 SUSD1 BEGAIN	3.31e-05	156	52	4	17c38d3b03fc38cb125cf0d165b2fd694cd88edd
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ZFHX4 SCARF2 BEND2 RYR2	4.21e-05	166	52	4	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	ZFHX4 SCARF2 BEND2 RYR2	4.21e-05	166	52	4	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM163A FCGBP ETV4 MORN5	4.52e-05	169	52	4	30141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCell	facs-Pancreas-Exocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 FCGBP OTOGL RBPJL	5.77e-05	180	52	4	72310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NPC1 LHCGR SLC41A2 IGFLR1	6.03e-05	182	52	4	9bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NPC1 LHCGR SLC41A2 IGFLR1	6.03e-05	182	52	4	4602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Ptprz1_(Ptprz1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RBPJL ETV4 UBASH3A	6.92e-05	68	52	3	9ce22a6dea3c17d5352572ea0dabe6c6120b9f82
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Ptprz1_(Ptprz1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RBPJL ETV4 UBASH3A	6.92e-05	68	52	3	89d337147899a978a7467db24e876a613bdd2288
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	VWC2 RYR2 RYR3 BEGAIN	8.35e-05	198	52	4	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell	Control-Control-Others-RBC\|Control / Disease, condition lineage and cell class	SLC41A2 SUSD1 IGFLR1 RYR3	8.51e-05	199	52	4	eb4c52d04f572433c0239bf479d0040a309939a1
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ZFHX4 SCARF2 ETV4	8.51e-05	199	52	4	edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCell	Sepsis-ICU-NoSEP-Myeloid-pDC\|ICU-NoSEP / Disease, condition lineage and cell class	NPC1 SLC41A2 SUSD1 IGFLR1	8.51e-05	199	52	4	a199e67438eeed903d0996605591ec54400fdd66
Drug	2-hydroxycarbazole	RYR2 RYR3	1.53e-05	3	52	2	CID000093551
Drug	cis-diammineplatinum(II	RYR2 RYR3	1.53e-05	3	52	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR2 RYR3	1.53e-05	3	52	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR2 RYR3	1.53e-05	3	52	2	CID005748312
Drug	8N3-cADPR	RYR2 RYR3	1.53e-05	3	52	2	CID000127713
Drug	aminodantrolene	RYR2 RYR3	1.53e-05	3	52	2	CID009570289
Drug	PCB74	RYR2 RYR3	3.06e-05	4	52	2	CID000036218
Drug	148504-47-6	RYR2 RYR3	3.06e-05	4	52	2	CID006444275
Drug	SC 38249	RYR2 RYR3	3.06e-05	4	52	2	CID000134834
Drug	AC1L1U7A	RYR2 RYR3	3.06e-05	4	52	2	CID000035682
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	FAM163A OTUD4 CLDN15 FAM149B1 VCPIP1	7.26e-05	190	52	5	6956_UP
Drug	MBED	RYR2 RYR3	7.63e-05	6	52	2	CID000129958
Drug	chloro-m-cresol	RYR2 RYR3	7.63e-05	6	52	2	CID000012008
Drug	AC1O528X	RYR2 RYR3	7.63e-05	6	52	2	CID006475857
Drug	NSC114784	RYR2 RYR3	7.63e-05	6	52	2	CID000419425
Drug	Tolnaftate [2398-96-1]; Up 200; 13uM; MCF7; HT_HG-U133A	OTUD4 FAM149B1 SKI MASP2 VCPIP1	8.61e-05	197	52	5	1501_UP
Drug	Biotin [58-85-5]; Up 200; 16.4uM; HL60; HT_HG-U133A	STAB2 FAM149B1 MASP2 BEGAIN VCPIP1	8.61e-05	197	52	5	2428_UP
Drug	Ethynylestradiol 3-methyl ether [72-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A	PCNX4 CLN5 DIDO1 CLDN15 FKBP8	8.82e-05	198	52	5	4792_DN
Drug	Azumoleno	RYR2 RYR3	1.07e-04	7	52	2	CID000056259
Drug	Br2BAPTA	RYR2 RYR3	1.07e-04	7	52	2	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR2 RYR3	1.07e-04	7	52	2	CID009547999
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	8.43e-06	3	50	2	DOID:8545 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	8.43e-06	3	50	2	DOID:3529 (implicated_via_orthology)
Disease	amino acid measurement	VWC2 SUSD1 PNKD MUC2 RYR2 RYR3	9.69e-04	678	50	6	EFO_0005134

Protein segments in the cluster

Peptide	Gene	Start	Entry
CDPGRGQPYVCYDPK	ERV3-1	71	Q14264
DDRPECPYGPSCYRK	APLF	416	Q8IW19
PGPRPPYKGDIYCSD	BEGAIN	216	Q9BUH8
QPPPYPGNIFRLKYC	ADAM20	396	O43506
AFYCDGPLPGPRDYA	AJM1	251	C9J069
GYGYEKPLRPFPDDV	ETV4	296	P43268
FKDLGDLCGPYYPEH	RAI1	1696	Q7Z5J4
YGNEKRFFCPPPCVY	RBPJL	81	Q9UBG7
YQDPLYPGFPCNEKG	OTUD4	661	Q01804
YEYGFCLPKTPRCAP	LHCGR	331	P22888
CIPPKYGYLGDPKRN	BEND2	471	Q8NDZ0
GGPRFKLGYCAPPYI	PCNX4	26	Q63HM2
EGCYPRCPKDRPIYE	MUC2	1161	Q02817
DLCEDYFKPPFGPYP	LRGUK	716	Q96M69
GDFKPYKPGQTYIPC	GNMT	271	Q14749
YGRAAPCDYGPAPAF	HOXB6	66	P17509
PCDYGPAPAFYREKE	HOXB6	71	P17509
GDKRYNCEYSGPPKP	NPC1	36	O15118
GYFPDGVYCRKLDPP	CD2BP2	311	O95400
GVYCRKLDPPGGQFY	CD2BP2	316	O95400
FRDPYFPAGPDALGY	CAPN12	46	Q6ZSI9
KYCYGPQGRSPYIPP	FKBP8	176	Q14318
PRQYKLFYAPAAGGP	COL12A1	1871	Q99715
YPLGEVFYPGPECER	FCGBP	4801	Q9Y6R7
ITGYKPAPGDLAYPD	COG3	476	Q96JB2
KEKADPYPYPGLVCG	IGFLR1	191	Q9H665
RPKPECEGYDPNALY	DIDO1	256	Q9BTC0
RPPPNAYELFAKGYE	PRMT5	291	O14744
FFDPLYPGTKYELGP	CLDN15	146	P56746
PVYKYPGKGCPTLGD	GP1BA	271	P07359
QKCTAAYEKPPYPRG	MASP2	596	O00187
RLSFAPTYYKEGGPP	FAM163A	121	Q96GL9
FKFLPPPGYAPCYEA	RYR2	811	Q92736
PPGYAPCYEAVLPKE	RYR2	816	Q92736
GKEYFDCRFPDPELP	OTOGL	846	Q3ZCN5
EKQKLGYPPIAPFYC	FAM149B1	251	Q96BN6
PGFPAEGRCGYYVEK	TRMT13	11	Q9NUP7
YLLDGEPYKGPSCLF	PNKD	236	Q8N490
FYLYKGKCLPTCPPG	RSPO4	111	Q2I0M5
EMGRCLASYPEPPGY	SAXO1	416	Q8IYX7
IPGELPDEPKGCYYP	SLC41A2	441	Q96JW4
PDEPKGCYYPFRTFF	SLC41A2	446	Q96JW4
YGGAYPPPCKKELAA	SKI	191	P12755
PYKRFDFRPKPDPYC	CLN5	56	O75503
PPEEYVYPDYRGKGC	VWC2	141	Q2TAL6
GYFPPVCGMESLFPY	ZFHX4	3236	Q86UP3
GPRPVYPCDLCGKSY	ZNF865	436	P0CJ78
RLGCPYVLDPEDYGP	VSIG8	41	P0DPA2
GEFKFLPPSGYAPCY	RYR3	796	Q15413
EPGYRGKYCREPCPA	SCARF2	261	Q96GP6
GKYCREPCPAGFYGL	SCARF2	266	Q96GP6
YCMDGYLPRNGPEPF	SUSD1	151	Q6UWL2
PNYRGDGKYCDPINP	STAB2	226	Q8WWQ8
PPYLQCIRYGFPPKE	VCPIP1	811	Q96JH7
FGLYCICKRPYPDPE	UBR7	131	Q8N806
TPDGKYYRPDLNFPC	UBASH3A	421	P57075
DPPRKIPKGYYDCGD	MORN5	111	Q5VZ52