Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessflagellated sperm motility

CACNA1E IFT88 CFAP44 CCDC38 DNAH5 DNAH11

5.12e-05186736GO:0030317
GeneOntologyBiologicalProcesssperm motility

CACNA1E IFT88 CFAP44 CCDC38 DNAH5 DNAH11

6.28e-05193736GO:0097722
GeneOntologyBiologicalProcesscilium movement involved in cell motility

CACNA1E IFT88 CFAP44 CCDC38 DNAH5 DNAH11

1.00e-04210736GO:0060294
GeneOntologyBiologicalProcesscilium-dependent cell motility

CACNA1E IFT88 CFAP44 CCDC38 DNAH5 DNAH11

1.14e-04215736GO:0060285
GeneOntologyBiologicalProcesscilium or flagellum-dependent cell motility

CACNA1E IFT88 CFAP44 CCDC38 DNAH5 DNAH11

1.14e-04215736GO:0001539
GeneOntologyBiologicalProcesstype III interferon production

IFIH1 GBP7

1.23e-045732GO:0034343
GeneOntologyBiologicalProcessregulation of type III interferon production

IFIH1 GBP7

1.23e-045732GO:0034344
GeneOntologyCellularComponenthost cell part

GBP7 GBP3

1.69e-046712GO:0033643
GeneOntologyCellularComponenthost intracellular part

GBP7 GBP3

1.69e-046712GO:0033646
GeneOntologyCellularComponenthost cell cytoplasm part

GBP7 GBP3

1.69e-046712GO:0033655
GeneOntologyCellularComponent9+0 motile cilium

DNAH5 DNAH11

1.69e-046712GO:0097728
GeneOntologyCellularComponentsymbiont-containing vacuole

GBP7 GBP3

1.69e-046712GO:0020003
GeneOntologyCellularComponentsymbiont-containing vacuole membrane

GBP7 GBP3

1.69e-046712GO:0020005
GeneOntologyCellularComponenthost intracellular region

GBP7 GBP3

1.69e-046712GO:0043656
GeneOntologyCellularComponenthost cell cytoplasm

GBP7 GBP3

1.69e-046712GO:0030430
GeneOntologyCellularComponentbeta-catenin-TCF complex

TCF7L2 TCF7L1

8.66e-0413712GO:1990907
GeneOntologyCellularComponenthost cellular component

GBP7 GBP3

1.16e-0315712GO:0018995
HumanPhenoIncreased circulating IgG3 level

STIM1 IFIH1

2.31e-052252HP:0032297
MousePhenobiventricular, ambiguous atrioventricular connection

DNAH5 DNAH11

1.58e-052562MP:0011511
MousePhenobiventricular, discordant atrioventricular connection

DNAH5 DNAH11

4.72e-053562MP:0011510
DomainHMG_BOX_2

TCF7L2 PBRM1 TAF1 TCF7L1

5.86e-0554734PS50118
DomainCTNNB1-bd_N

TCF7L2 TCF7L1

9.00e-054732IPR013558
DomainCTNNB1_binding

TCF7L2 TCF7L1

9.00e-054732PF08347
DomainTCF/LEF

TCF7L2 TCF7L1

9.00e-054732IPR024940
DomainHECT

NEDD4L UBR5 HERC6

1.57e-0427733PF00632
DomainHECTc

NEDD4L UBR5 HERC6

1.57e-0427733SM00119
DomainHECT_dom

NEDD4L UBR5 HERC6

1.57e-0427733IPR000569
DomainHECT

NEDD4L UBR5 HERC6

1.57e-0427733PS50237
DomainDHC_N1

DNAH5 DNAH11

4.16e-048732PF08385
DomainResIII

IFIH1 FANCM

4.16e-048732PF04851
DomainDynein_heavy_dom-1

DNAH5 DNAH11

4.16e-048732IPR013594
DomainHelicase/UvrB_N

IFIH1 FANCM

4.16e-048732IPR006935
DomainGBP_C

GBP7 GBP3

6.64e-0410732PF02841
DomainG_GB1_RHD3_dom

GBP7 GBP3

8.10e-0411732IPR030386
DomainGuanylate-bd_C

GBP7 GBP3

8.10e-0411732IPR003191
DomainGBP

GBP7 GBP3

8.10e-0411732PF02263
DomainGuanylate-bd_N

GBP7 GBP3

8.10e-0411732IPR015894
DomainG_GB1_RHD3

GBP7 GBP3

8.10e-0411732PS51715
DomainHMG_box

TCF7L2 PBRM1 TCF7L1

1.17e-0353733PF00505
DomainHMG

TCF7L2 PBRM1 TCF7L1

1.23e-0354733SM00398
Domain-

TCF7L2 PBRM1 TCF7L1

1.30e-03557331.10.30.10
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH11

1.33e-0314732IPR024317
DomainDynein_HC_stalk

DNAH5 DNAH11

1.33e-0314732IPR024743
DomainDynein_heavy_dom-2

DNAH5 DNAH11

1.33e-0314732IPR013602
DomainDHC_N2

DNAH5 DNAH11

1.33e-0314732PF08393
DomainMT

DNAH5 DNAH11

1.33e-0314732PF12777
DomainAAA_8

DNAH5 DNAH11

1.33e-0314732PF12780
DomainATPase_dyneun-rel_AAA

DNAH5 DNAH11

1.33e-0314732IPR011704
DomainAAA_5

DNAH5 DNAH11

1.33e-0314732PF07728
DomainDHC_fam

DNAH5 DNAH11

1.53e-0315732IPR026983
DomainDynein_heavy_dom

DNAH5 DNAH11

1.53e-0315732IPR004273
DomainDynein_heavy

DNAH5 DNAH11

1.53e-0315732PF03028
DomainHMG_box_dom

TCF7L2 PBRM1 TCF7L1

2.10e-0365733IPR009071
DomainTPR-like_helical_dom

TRANK1 IFT88 NAPG PRKDC EDRF1

2.18e-03233735IPR011990
Domain-

IFIH1 CACNB3 TRANK1 GBP7 SHPRH GBP3 FANCM DNAH5 DNAH11

2.43e-037467393.40.50.300
DomainTPR-contain_dom

TRANK1 IFT88 PRKDC EDRF1

2.83e-03150734IPR013026
Domain-

UBR5 HERC6

3.31e-03227322.130.10.30
DomainRCC1/BLIP-II

UBR5 HERC6

3.61e-0323732IPR009091
DomainTPR_REGION

TRANK1 IFT88 PRKDC EDRF1

3.98e-03165734PS50293
DomainTPR

TRANK1 IFT88 PRKDC EDRF1

3.98e-03165734PS50005
DomainBromodomain_CS

PBRM1 TAF1

4.61e-0326732IPR018359
DomainKinase-like_dom

STK32A CDK18 PTPN13 STK32B PRKDC STK32C DMPK

5.20e-03542737IPR011009
DomainP-loop_NTPase

IFIH1 CACNB3 TRANK1 GBP7 SHPRH GBP3 FANCM DNAH5 DNAH11

5.65e-03848739IPR027417
DomainCatenin_binding_dom

TCF7L2 TCF7L1

5.71e-0329732IPR027397
Domain-

TCF7L2 TCF7L1

5.71e-03297324.10.900.10
PathwayREACTOME_RUNX3_REGULATES_WNT_SIGNALING

TCF7L2 TCF7L1

2.22e-046552MM15542
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_AVRA_TO_BETA_CATENIN_SIGNALING_PATHWAY

TCF7L2 TCF7L1

2.22e-046552M47736
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_LANA_TO_WNT_SIGNALING_PATHWAY

TCF7L2 TCF7L1

3.10e-047552M47465
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION

TCF7L2 TCF7L1

4.12e-048552MM17229
PathwayREACTOME_BINDING_OF_TCF_LEF_CTNNB1_TO_TARGET_GENE_PROMOTERS

TCF7L2 TCF7L1

4.12e-048552M27359
PathwayKEGG_MEDICUS_VARIANT_CDH1_REDUCED_EXPRESSION_TO_BETA_CATENIN_SIGNALING_PATHWAY

TCF7L2 TCF7L1

4.12e-048552M47413
PathwayREACTOME_RUNX3_REGULATES_WNT_SIGNALING

TCF7L2 TCF7L1

4.12e-048552M27821
Pubmed

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

EVC2 IFT88 DNAH5 DNAH11

2.31e-072574427340223
Pubmed

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.

TCF7L2 IFT88 TCF7L1

3.31e-061474315226261
Pubmed

Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.

TCF7L2 TCF7L1

4.47e-0627429916915
Pubmed

Non-viral reprogramming of fibroblasts into induced pluripotent stem cells by Sleeping Beauty and piggyBac transposons.

PGBD1 PRKDC

4.47e-06274224928388
Pubmed

A gene family of HMG-box transcription factors with homology to TCF-1.

TCF7L2 TCF7L1

4.47e-0627421741298
Pubmed

Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.

DNAH5 DNAH11

4.47e-06274232357925
Pubmed

Ciliary defects and genetics of primary ciliary dyskinesia.

DNAH5 DNAH11

4.47e-06274219410201
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

KNTC1 CDK18 SORBS2 PTPN13 UBR5 PPFIBP1 PRKDC NUDC

4.94e-0644674824255178
Pubmed

Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.

TCF7L2 TCF7L1

1.34e-05374217607356
Pubmed

A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.

TCF7L2 TCF7L1

1.34e-05374225659031
Pubmed

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.

TCF7L2 TCF7L1

1.34e-05374224463605
Pubmed

Reproductive and neurological Quaking(viable) phenotypes in a severe combined immune deficient mouse background.

PRKDC QKI

1.34e-05374215900494
Pubmed

TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers.

TCF7L2 TCF7L1

1.34e-05374220532534
Pubmed

GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.

GBP7 GBP3

1.34e-05374235780181
Pubmed

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.

TCF7L2 TCF7L1

1.34e-05374234525377
Pubmed

Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.

TCF7L2 TCF7L1

1.34e-05374232403323
Pubmed

Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population.

TCF7L2 PTPN13

1.34e-05374224338422
Pubmed

GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis.

GBP7 GBP3

1.34e-05374229128363
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

STIM1 DOCK4 CDK18 SORBS2 PTPN13 NEDD4L PPFIBP1 CBX4 STK32C EDRF1

1.41e-05861741036931259
Pubmed

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

PBRM1 UBR5 MRTO4 PRKDC NUDC SDAD1

1.71e-0525374629911972
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

KNTC1 TCF7L2 PBRM1 GPC4 PRKDC TAF1 CUX1

2.27e-0539874735016035
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

NEDD4L UBR5 HERC6

2.32e-052674326949039
Pubmed

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.

TCF7L2 TCF7L1

2.67e-05474233587034
Pubmed

Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence.

EVC2 STK32B

2.67e-05474218454448
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAH5 DNAH11

2.67e-05474218492703
Pubmed

Mapping canonical Wnt signaling in the developing and adult retina.

TCF7L2 TCF7L1

2.67e-05474217065530
Pubmed

The protein kinase complement of the human genome.

STK32A STK32B STK32C

2.92e-052874312471243
Pubmed

Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.

TCF7L2 TCF7L1

4.45e-05574221285352
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1E CACNB3

4.45e-0557428825650
Pubmed

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

DNAH5 DNAH11

4.45e-05574222499950
Pubmed

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.

DNAH5 DNAH11

4.45e-05574226909801
Pubmed

CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.

IFT88 CCDC38

4.45e-05574235587122
Pubmed

Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.

GBP7 GBP3

4.45e-05574231964735
Pubmed

CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.

IFT88 CCDC38

6.66e-05674238038747
Pubmed

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

DNAH5 DNAH11

6.66e-05674233347437
Pubmed

Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations.

EVC2 STK32B

6.66e-05674220087401
Pubmed

Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.

TCF7L2 TCF7L1

6.66e-0567429488439
Pubmed

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.

TCF7L2 TCF7L1

6.66e-05674223152144
Pubmed

Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures.

TCF7L2 TCF7L1

6.66e-05674211731231
Pubmed

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

TCF7L2 ADCY5

6.66e-05674220081857
Pubmed

Dazap2 modulates transcription driven by the Wnt effector TCF-4.

TCF7L2 TCF7L1

6.66e-05674219304756
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

STIM1 CDK18 SENP1 PTPN13 UBR5 PPFIBP1 MRTO4 NUDC EDRF1 CUX1 ATP6V0A2 LRRC47

6.72e-051487741233957083
Pubmed

Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.

TCF7L2 ADCY5

9.31e-05774227049325
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH5 DNAH11

9.31e-0577429256245
Pubmed

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells.

TCF7L2 TCF7L1

9.31e-05774232820720
Pubmed

RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.

TCF7L2 TCF7L1

9.31e-05774218772112
Pubmed

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response.

IFIH1 SNX8

9.31e-05774233110251
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH5 DNAH11

9.31e-05774231178125
Pubmed

Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo.

TCF7L2 TCF7L1

9.31e-05774219303461
Pubmed

Connective tissue fibroblasts and Tcf4 regulate myogenesis.

TCF7L2 TCF7L1

1.24e-04874221177349
Pubmed

Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.

UBR5 CBX4

1.24e-04874220351170
Pubmed

TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.

TCF7L2 TCF7L1

1.24e-04874232179550
Pubmed

In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.

GBP7 GBP3

1.24e-04874216689661
Pubmed

The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer.

IFIH1 PBRM1

1.24e-04874228940253
Pubmed

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

CALCR ADCY5

1.59e-04974223202124
Pubmed

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

GBP7 GBP3

1.59e-04974224739961
Pubmed

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.

TCF7L2 TCF7L1

1.59e-04974217335794
Pubmed

Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3.

TCF7L2 IFT88

1.99e-041074236043912
Pubmed

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.

TCF7L2 TCF7L1

1.99e-041074222393260
Pubmed

A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.

UBR5 PRKDC CUX1

2.24e-045574334237211
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

KNTC1 TCF7L2 UBR5 PPFIBP1 NAPG MRTO4 PRKDC NUDC SDAD1 CUX1 LRRC47

2.25e-041440741130833792
Pubmed

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

GBP7 GBP3

2.43e-041174224715728
Pubmed

Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis.

TCF7L2 IFT88

2.43e-041174236825984
Pubmed

Ndfip1 is required for the development of pyramidal neuron dendrites and spines in the neocortex.

NEDD4L CUX1

2.43e-041174223897647
Pubmed

MRE11 complex links RECQ5 helicase to sites of DNA damage.

UBR5 PRKDC

2.43e-041174219270065
Pubmed

Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung.

TCF7L2 TCF7L1

2.43e-041174211731265
Pubmed

Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.

TCF7L2 TCF7L1

2.43e-041174229751817
Pubmed

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.

TCF7L2 ADCY5

2.43e-041174222693455
Pubmed

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.

GBP7 GBP3

2.43e-041174218025219
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

CDK18 SENP1 UBR5 SHPRH PARP9

2.46e-0426274536880596
Pubmed

Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.

GBP7 GBP3

2.91e-041274235906252
Pubmed

Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors.

TCF7L2 TCF7L1

2.91e-041274232414917
Pubmed

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.

TCF7L2 TCF7L1

2.91e-041274210631168
Pubmed

Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer.

SENP1 CBX4

2.91e-041274236793866
Pubmed

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

TCF7L2 TCF7L1

2.91e-041274211266540
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

CACNA1E CDK18 SORBS2 PTPN13 UBR5 MTCH1

3.14e-0443074632581705
Pubmed

The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.

DNAH5 DNAH11

3.43e-041374217884984
Pubmed

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.

TCF7L2 TCF7L1

3.43e-041374219718027
Pubmed

Investigation of genes important in neurodevelopment disorders in adult human brain.

TCF7L2 TCF7L1

3.43e-041374226194112
Pubmed

BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin.

UBR5 CBX4

3.43e-041374227647897
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

DOCK4 PPFIBP1 MRTO4 PRKDC

3.51e-0415674422952844
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SORBS2 PTPN13 IFT88 PPFIBP1 ANKRD36 PRKDC TAF1 QKI PREX1 CUX1

3.84e-041285741035914814
Pubmed

Primary cilia are required in a unique subpopulation of neural progenitors.

IFT88 CUX1

4.00e-041474225114218
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH5 DNAH11

4.00e-04147429373155
Pubmed

Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.

TCF7L2 TCF7L1

4.00e-041474233195246
Pubmed

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.

TCF7L2 TCF7L1

4.00e-041474210090727
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1E CACNB3

4.61e-041574220188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1E CACNB3

4.61e-041574224453333
Pubmed

Phases of canonical Wnt signaling during the development of mouse intestinal epithelium.

TCF7L2 TCF7L1

4.61e-041574217681174
Pubmed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

TCF7L2 TCF7L1

4.61e-041574215866165
Pubmed

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.

TCF7L2 TCF7L1

5.26e-041674230886049
Pubmed

DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

PRKDC CUX1

5.26e-041674228123024
Pubmed

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

NEDD4L UBR5

5.26e-041674222496338
Pubmed

Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.

NEDD4L ZNF407

5.95e-041774219690890
Pubmed

Probing nuclear pore complex architecture with proximity-dependent biotinylation.

SENP1 PRKDC NUDC

6.04e-047774324927568
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

STIM1 DOCK4 PPFIBP1 DUSP3 QKI NUDC DNAH11

6.63e-0468974736543142
Pubmed

Genome-wide association of mood-incongruent psychotic bipolar disorder.

TRANK1 PBRM1

6.68e-041874223092984
Pubmed

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.

TCF7L2 TCF7L1

6.68e-041874222166339
Pubmed

TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis.

UBR5 SDAD1

6.68e-041874232924931
Pubmed

Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.

TCF7L2 UBR5

6.68e-041874228689657
InteractionTCF7L1 interactions

TCF7L2 TAF1 TCF7L1

9.01e-0612713int:TCF7L1
GeneFamilyX-linked mental retardation|RNA helicases

IFIH1 FANCM

2.86e-04114221168
GeneFamilyDyneins, axonemal

DNAH5 DNAH11

7.01e-0417422536
GeneFamilyCalcium voltage-gated channel subunits

CACNA1E CACNB3

1.65e-0326422253
CoexpressionFIRESTEIN_PROLIFERATION

STK32A STK32B PRKDC TAF1 STK32C DMPK

7.06e-06166736M5354
CoexpressionGSE42021_CD24INT_VS_CD24LOW_TREG_THYMUS_DN

IFIH1 LGMN CDK18 TRANK1 HERC6 CFAP44

1.82e-05196736M9590
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

STK32A SORBS2 PTPN13 NEDD4L DNAH5 FAAH2 DNAH11

2.83e-08188747c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-2|TCGA-Mesothelium / Sample_Type by Project: Shred V9

DOCK4 SORBS2 TRANK1 STK32B PARP9 HERC6

2.79e-07160746d288b0a315f6adc0be4bdc89fa67bf93679a743f
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

IFIH1 LGMN TRANK1 GBP3 PARP9 HERC6

7.89e-071917462da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFIH1 TRANK1 GBP3 PARP9 HERC6

7.73e-06163745d005115aa1e1458b51de7eb719794617a4168608
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPN13 NEDD4L GPC4 DNAH5 FAAH2

8.44e-06166745c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCellThalamus-Neuronal-Excitatory|Thalamus / BrainAtlas - Mouse McCarroll V32

TCF7L2 NEDD4L AIFM3 NAPG STK32C

1.12e-05176745d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CALCR CERS4 LRRC9

1.15e-051777458e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

IFIH1 TRANK1 GBP3 PARP9 HERC6

1.22e-05179745af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CDK18 SORBS2 STK32B STK32C CUX1

1.32e-051827451647367b75b4b107af06bb934394168230cfd7c2
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOCK4 IFIH1 TRANK1 GBP3 PARP9

1.43e-05185745f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

STK32A PTPN13 NEDD4L DNAH5 FAAH2

1.43e-05185745cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 PPFIBP1 STMN2 CERS4 LRRC9

1.46e-051867454ae3c0fe8640a8d029875cf3f0f5ffbba38e85f8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IFT88 GPC4 TCF7L1 ADCY5 DNAH11

1.46e-05186745f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

CROT PTPN13 NEDD4L DNAH5 TCF7L1

1.50e-051877458407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

IFIH1 TRANK1 GBP3 PARP9 HERC6

1.54e-051887456f8946d4710f6e32c937213f99b790b098b8819c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS2 PPFIBP1 GPC4 CERS4 CUX1

1.62e-05190745989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SORBS2 PTPN13 NEDD4L DNAH5 CERS4

1.66e-0519174523776c7302cead3881b39127398f3b3e0d27885e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

PTPN13 NEDD4L GPC4 DNAH5 TCF7L1

1.70e-0519274506013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

SORBS2 PTPN13 NEDD4L DNAH5 TCF7L1

1.70e-05192745efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

IFIH1 TRANK1 GBP3 PARP9 HERC6

1.84e-05195745b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellmild-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

IFIH1 TRANK1 GBP3 PARP9 HERC6

1.88e-05196745ded44b38ea489946e9eedfe752b5a9fde9149c16
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

IFIH1 TRANK1 PARP9 HERC6 FAAH2

1.88e-05196745daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

SORBS2 NEDD4L CFAP44 DNAH5 DNAH11

1.88e-0519674587d9881cfec461a5d89b688a83749b618c519485
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PTPN13 NEDD4L DNAH5 CERS4 FAAH2

1.98e-051987455fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 PTPN13 NEDD4L ZNF407 CUX1

1.98e-051987451996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellCV-Mild-1|CV / Virus stimulation, Condition and Cluster

IFIH1 TRANK1 GBP3 PARP9 HERC6

1.98e-051987454b078714c49e7befb7b113d72485e712236d35fa
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Macroglial-Glia_progenitor_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

IFIH1 GPC4 AIFM3 GBP3 CERS4

2.07e-05200745859f98f63797087e7df18be632de153009b6cab1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CACNA1E CACNB3 NEDD4L STK32B STMN2

2.07e-052007455b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 CCDC73 DUSP3 CCDC38

6.95e-05132744fc79898eeb39c26505cf04df95c3dd75a6593295
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

XKR9 DNAH5 DNAH11 LRRC9

1.26e-041547444e3bc24043144143842627cacf6f90dda2228910
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP44 DNAH5 DNAH11 LRRC9

1.26e-041547449ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

XKR9 DNAH5 DNAH11 LRRC9

1.26e-041547447556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP44 DNAH5 DNAH11 LRRC9

1.26e-0415474458072ce422d09f2de602580325eaac6c4ec6c136
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP44 DNAH5 DNAH11 LRRC9

1.29e-041557445f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP44 DNAH5 DNAH11 LRRC9

1.29e-041557440944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellLPS-antiTNF-Endothelial-Epi-like-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CDK18 GBP7 CBX4 STK32C

1.36e-04157744abfd05ed993b80822739f47a735f154092a23632
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CALCR LRRC9

1.46e-04160744174a4ab27114efcc63be36929b80680be3c35c9b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CALCR CERS4

1.46e-041607441e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

STK32A PROKR2 GBP7 SNX8

1.50e-04161744bf70be1de418615b5442ec684552551edaf1f072
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

STK32A PROKR2 STK32B SNX8

1.50e-04161744dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB3 STK32C DMPK TCF7L1

1.57e-04163744b83a35c4426d66b5734a98fa6c72b345fe462030
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB3 STK32C DMPK TCF7L1

1.57e-04163744c20ca9b6b4170ebcb0e66eef3e5d8ebff22b1a91
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN13 ANKRD36 PRKDC FAAH2

1.72e-0416774483969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK4 GBP7 GBP3 PARP9

1.72e-04167744774f3264318b002d0df5d06d41d645366038d0bf
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN TCF7L2 PCOLCE2 DMPK

1.80e-0416974444d841fd997a6f26104f16cd00223ecce8352f43
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CERS4 LRRC9

1.80e-041697442a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SORBS2 PTPN13 LIPN CFAP44

1.80e-04169744c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CALCR LRRC9

1.80e-041697444b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CALCR LRRC9

1.80e-04169744a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SORBS2 PTPN13 LIPN CFAP44

1.80e-04169744ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCellfacs-Lung-nan-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 SORBS2 PGBD1 CUX1

1.84e-041707448e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCellfacs-Lung-nan-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 SORBS2 PGBD1 CUX1

1.84e-0417074467d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DOCK4 PPFIBP1 SNX8 LIPN

1.84e-04170744cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 ZFYVE9 GBP7 STMN2

1.97e-0417374466488d01e03264fb193285470901c9c4182fbae8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CERS4 LRRC9

1.97e-041737440bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFIH1 GBP3 PARP9 HERC6

2.06e-0417574497616bb5c127284aa9e67bc336dfcf29e137164b
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CDK18 SORBS2 UBR5 STK32C

2.06e-04175744085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CERS4 LRRC9

2.10e-041767446c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L2 PTPN13 DMPK PREX1

2.10e-041767445e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFIH1 GBP7 GBP3 HERC6

2.20e-0417874401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_THTPA|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IFIH1 CDK18 STK32B CUX1

2.20e-04178744e4e11e4940c911c17806200c25096928153c684d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 NEDD4L CERS4 DNAH11

2.20e-0417874451d2188406f04329311b2efd1108fc36617a860e
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CROT PTPN13 NEDD4L DNAH5

2.20e-04178744fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CDK18 SORBS2 STK32B CUX1

2.24e-04179744820289f14ecf165758529c236bb220bb1a744f02
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CDK18 SORBS2 STK32B CUX1

2.24e-04179744e5f781d35449628a7f356d71e26231dd63482eec
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPN13 NEDD4L DNAH5 FAAH2

2.29e-04180744b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CDK18 SORBS2 STK32B CUX1

2.29e-041807447a9aa96fb8035020640cc7d3df0c41c730516c6f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SORBS2 PPFIBP1 STK32B CUX1

2.34e-0418174413270b6ba6a9c8e5681c6f40000c643ce1d9344a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SORBS2 PPFIBP1 STK32B CUX1

2.34e-041817443e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCellRV|World / Chamber and Cluster_Paper

SORBS2 PPFIBP1 QKI ADCY5

2.34e-04181744bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STK32A STK32B PCOLCE2 DNAH11

2.39e-04182744a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SORBS2 NEDD4L DNAH5 CERS4

2.39e-04182744215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STK32A STK32B PCOLCE2 DNAH11

2.39e-04182744831b5ce46b41efe01c4db6016c2f43148611373d
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NEDD4L DNAH5 CERS4 FAAH2

2.39e-041827443f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCellCiliated_cells-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CFAP44 DNAH5 DNAH11 LRRC9

2.39e-04182744e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN TCF7L2 PCOLCE2 DMPK

2.44e-04183744c12a4603cf81b5736553a4530cea5cefab80556f
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

IFIH1 TRANK1 GBP3 PARP9

2.44e-041837448f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 GBP3 PARP9 HERC6

2.44e-04183744e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCellLPS-IL1RA|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 EVC2 GBP7 GBP3

2.49e-04184744c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFT88 DNAH5 DNAH11 LRRC9

2.49e-04184744264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFT88 DNAH5 DNAH11 LRRC9

2.49e-04184744d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFT88 DNAH5 DNAH11 LRRC9

2.49e-0418474422010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCelldroplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK32A SORBS2 STK32B STMN2

2.54e-04185744eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCellControl-Epithelial_alveolar-AT_2-AT2_Progenitor|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STK32A LGMN PTPN13 CERS4

2.54e-041857448ca1374501eca01d8468130b74d50abfd4329fbe
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A SORBS2 STK32B STMN2

2.60e-04186744b80aaeebc03a318052076d2f02c123f5ddc5e73a
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A SORBS2 STK32B STMN2

2.60e-041867448a8ed1502542d4895cba3fd5d534256206578716
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CROT DMPK CERS4 CUX1

2.60e-041867442913b5fd0617d024d600ba7015ec7b1961dade83
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 STMN2 DMPK ADCY5

2.65e-04187744ddfc2d1d9fcc3d8e4d3d015576bb17eebf44ada9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 SORBS2 PPFIBP1 STMN2

2.65e-041877443548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STK32A STK32B QKI DNAH11

2.65e-04187744daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

PTPN13 NEDD4L DNAH5 FAAH2

2.65e-0418774481cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IFT88 GPC4 TCF7L1 ADCY5

2.65e-04187744c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 SORBS2 PPFIBP1 STMN2

2.65e-04187744f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STK32A STK32B QKI DNAH11

2.65e-041877445b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 SORBS2 PPFIBP1 STMN2

2.65e-0418774481754e965848b718be20ee97ce072ce426938a69
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

NEDD4L CERS4 FAAH2 DNAH11

2.65e-04187744ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IFT88 GPC4 TCF7L1 ADCY5

2.70e-04188744af740fa78542438fdff627ea1f74f4eee43316be
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 STMN2 DMPK ADCY5

2.70e-04188744d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIBP1 STK32B GPC4 DNAH11

2.70e-0418874463a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA1E TRANK1 STMN2 NAPG

2.70e-04188744b73e8a40393c3f656e2fcfe395a761b1f985c254
DiseaseMetastatic melanoma

STK32A STK32B PRKDC TAF1

8.89e-0654714C0278883
Diseasebody fat percentage, fasting blood glucose measurement

TCF7L2 ADCY5

1.71e-053712EFO_0004465, EFO_0007800
DiseaseKartagener syndrome (is_implicated_in)

DNAH5 DNAH11

3.41e-054712DOID:0050144 (is_implicated_in)
Diseaselongitudinal BMI measurement

DOCK4 CACNA1E EVC2 CALCR

4.67e-0582714EFO_0005937
DiseaseAdenocarcinoma of large intestine

UBR5 PRKDC TAF1 CUX1

8.65e-0596714C1319315
DiseaseColorectal Carcinoma

EVC2 TCF7L2 SNX8 STK32C QKI EDRF1 CUX1 LRRC47

2.80e-04702718C0009402
DiseaseKartagener syndrome (implicated_via_orthology)

DNAH5 DNAH11

5.10e-0414712DOID:0050144 (implicated_via_orthology)
Diseasehistidine measurement

SNX8 STK32C CCDC38

5.48e-0466713EFO_0009769
Diseasebody mass index, type 2 diabetes mellitus

TCF7L2 ADCY5

6.70e-0416712EFO_0004340, MONDO_0005148
Diseasecutaneous Leishmaniasis

TCF7L2 CALCR

6.70e-0416712EFO_0005046
Diseasebody fat percentage, type 2 diabetes mellitus

TCF7L2 ADCY5

7.58e-0417712EFO_0007800, MONDO_0005148
DiseaseLung diseases

PRKDC DNAH5 DNAH11

8.92e-0478713C0024115
DiseaseBronchiectasis

DNAH5 DNAH11

1.28e-0322712C0006267
DiseaseBMI-adjusted fasting blood glucose measurement

TCF7L2 ADCY5

1.40e-0323712EFO_0008036
DiseaseCoronary heart disease

TCF7L2 DNAH11

1.52e-0324712C0010068
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor

CBX4 CUX1

1.52e-0324712EFO_0003761, EFO_0005658
Diseaselobe attachment

SHPRH LIPN PRKDC CUX1

1.58e-03207714EFO_0007667
Diseasefasting blood glucose measurement, HOMA-B, fasting blood insulin measurement

TCF7L2 ADCY5

1.65e-0325712EFO_0004465, EFO_0004466, EFO_0004469
Diseaseglucose tolerance test

TCF7L2 ADCY5

1.93e-0327712EFO_0004307
Diseaselissencephaly (implicated_via_orthology)

CDK18 NUDC

1.93e-0327712DOID:0050453 (implicated_via_orthology)
Diseaseplatelet component distribution width

STIM1 TRANK1 QKI PREX1 TCF7L1 ADCY5 CUX1

2.25e-03755717EFO_0007984
Diseasebowel opening frequency

CDK18 XKR9

2.38e-0330712EFO_0600084
DiseaseCiliopathies

EVC2 DNAH5 DNAH11

2.40e-03110713C4277690

Protein segments in the cluster

PeptideGeneStartEntry
MLYSFMKKGQMEKDI

CERS4

326

Q9HA82
QMKHLTVQMMAYDKL

CACNB3

311

P54284
AMMIMDYYKQSKVKK

CACNA1E

1871

Q15878
MKMFENNRVKFYMQT

AIFM3

381

Q96NN9
KKMMDAQYKCYDRMQ

CALCR

46

P30988
MIMNKMKNFKRRFSL

CDK18

1

Q07002
MKRMEKKAYMKRRHS

CUX1

1201

P39880
QDMEYHIEVMKKKMY

DNAH11

186

Q96DT5
MKDIEKMYKSGYNTM

ANKRD36

1696

A6QL64
LADFAMKLMDQMKYI

ADCY5

1151

O95622
LMMKTKEHTRKLYQM

CFAP44

1756

Q96MT7
DYLMQLMNDKKLMSS

QKI

16

Q96PU8
NEVLMAAFQRKKKMM

PARP9

676

Q8IXQ6
MKKIMYYNMRIKTLQ

LRRC9

246

Q6ZRR7
MEKIRSHMMANKYQD

PBRM1

706

Q86U86
SNKKNMNQSRMDVYM

LIPN

266

Q5VXI9
NMLVQFLMEMYKMKK

MAGEB3

116

O15480
MKIKVGQMQYEKQRM

PPFIBP1

241

Q86W92
MALRVMTSKMKNAYN

GPC4

466

O75487
YKVACNMMMKKNQNK

EDRF1

461

Q3B7T1
MDALILKMAEMKKYT

LRRC47

496

Q8N1G4
MKSLRSPMMNNKYKM

FANCM

1566

Q8IYD8
GQMEMLKLTMNKRYN

NXF5

101

Q9H1B4
HIKMQMSEKKAYMLM

HERC6

641

Q8IVU3
ETRKKMENQYQREMM

EVC2

461

Q86UK5
LAKTKYFQMLKMHAM

KNTC1

2141

P50748
AKMVEEMQIKYQQMM

GBP3

501

Q9H0R5
YMRELRKMLSHKMKV

GBP7

541

Q8N8V2
MPNSFIMMFKTKNQK

PCOLCE2

391

Q9UKZ9
MIYSLRNKDVKKAMM

OR5M3

286

Q8NGP4
VYAMKIMNKWDMLKR

DMPK

96

Q09013
QEMMKVLNRMKYEIT

MGAT4D

61

A6NG13
QMERERKAMAEKYIM

IFT88

366

Q13099
NLSKMRMMEASLYDK

DOCK4

1291

Q8N1I0
AMAVFKKQLQMKMCA

CCDC73

86

Q6ZRK6
EKMMYKAIHCVQNMK

IFIH1

851

Q9BYX4
MSKYMENGMQAVKIK

CBX4

266

O00257
KKMKYSFQLWIAMMS

FAAH2

351

Q6GMR7
MAAKETEKFMNRNMK

CCDC38

41

Q502W7
IAYLMMRQKMDVKSA

DUSP3

136

P51452
KRNFSNMKMMLAEYQ

DNAH5

746

Q8TE73
NMKMMLAEYQRVKSK

DNAH5

751

Q8TE73
KHSRMFFGKNKVMMV

MRTO4

61

Q9UKD2
QKMLQAFAKHNKMMK

CROT

481

Q9UKG9
MKNYMKKSSYMQDSA

PTPN13

1196

Q12923
NYQMIMNKGVFMKLI

OR10A6

131

Q8NH74
LKKVVKETSYEMMMQ

MTCH1

191

Q9NZJ7
LHKYSLMKRQMMSAT

SNX8

346

Q9Y5X2
MMQVGMATKIKNYYK

TAF1

691

P21675
LYHMMMNKKVNLIKD

PREX1

416

Q8TCU6
INFYMNMLMERSKEK

SENP1

471

Q9P0U3
NSRMKKFNQLMKKVM

SHPRH

231

Q149N8
KKQKNFMMMRYSQNV

SDAD1

646

Q9NVU7
MNVEHMKKMKRGYFD

PGBD1

661

Q96JS3
QKNDTKKMYAMKYMN

STK32A

41

Q8WU08
YIQNRYSKEHMKKMM

STIM1

231

Q13586
MVEKMMYDQRQKSMG

NUDC

286

Q9Y266
KMYKKMHRINRKDLM

SORBS2

451

O94875
QKRDTEKMYAMKYMN

STK32C

111

Q86UX6
EKMYAMKYMNKQQCI

STK32C

116

Q86UX6
KAYEQAGMMLKEMQK

NAPG

76

Q99747
NAFMLYMKEMRAKVV

TCF7L1

351

Q9HCS4
AFMLYMKEMRAKVVA

TCF7L2

356

Q9NQB0
KEERGMKIYYMQVQM

FAM170A

121

A1A519
VKNNTMKYFKKMMLL

PROKR2

336

Q8NFJ6
FSMKMKMIDSARKQN

PRKDC

3236

P78527
MAYKEKMKELSMLSL

STMN2

6

Q93045
QKRDTKKMYAMKYMN

STK32B

41

Q9NY57
TQRMYMKHLRTQMKT

ZNF407

456

Q9C0G0
AAKYLSANKMKEMMA

TRANK1

1871

O15050
SNRYNEMMKAMNKSN

ZFYVE9

1141

O95405
KMSYAANLKNVMNMQ

UBR5

2101

O95071
QVKKMKAIYHMLNMC

ATP6V0A2

301

Q9Y487
MKYTKQNFMMSVLGI

XKR9

1

Q5GH70
STMKVMQFQGMKRKA

LGMN

276

Q99538
YKMMLGKQITLNDME

NEDD4L

736

Q96PU5