Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone deacetylase binding	KLF4 SMYD4 RFXANK CDC20 HSP90AA1 RAD9A	7.29e-05	147	95	6	GO:0042826
GeneOntologyMolecularFunction	ATP-dependent activity	RAD51B DNHD1 ATG7 DYNC2H1 ABCA13 ATAD2 MDN1 ABCC8 NAV3 POLQ HSP90AA1	1.60e-04	614	95	11	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	RAD51B DYNC2H1 ABCA13 ATAD2 MDN1 ABCC8 NAV3 POLQ HSP90AA1	2.53e-04	441	95	9	GO:0016887
GeneOntologyMolecularFunction	beta-catenin binding	APC KLF4 DCHS1 CTNND1 SUFU	2.71e-04	120	95	5	GO:0008013
Domain	ARM-like	MROH9 SMG1 DOCK8 APC MEI1 ATAD2 LRBA CTNND1 TARBP1 TNPO3	1.41e-06	270	97	10	IPR011989
Domain	AAA+_ATPase	RAD51B DYNC2H1 ABCA13 ATAD2 MDN1 ABCC8 NAV3	1.01e-05	144	97	7	IPR003593
Domain	AAA	RAD51B DYNC2H1 ABCA13 ATAD2 MDN1 ABCC8 NAV3	1.01e-05	144	97	7	SM00382
Domain	ARM-type_fold	MROH9 SMG1 DOCK8 APC MEI1 LRBA CTNND1 TARBP1 TNPO3	6.76e-05	339	97	9	IPR016024
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TBC1D9B CYB561D2 REV3L KLF4 PCNX2 KMT2C INTS5 MDN1 MTMR3 NINL NLRC5 STEAP3 LRBA SUFU TNPO3 EVI5L RAD9A	1.05e-08	1105	97	17	35748872
Pubmed	Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.	NLRP11 MEFV NLRC5	2.09e-07	5	97	3	12615073
Pubmed	p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.	APC CTNND1	7.70e-06	2	97	2	29130932
Pubmed	Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis.	APC KLF4	7.70e-06	2	97	2	9428642
Pubmed	Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression.	KLF4 CRYAB	7.70e-06	2	97	2	27105535
Pubmed	KLF4 is a novel regulator of the constitutively expressed HSP90.	KLF4 HSP90AA1	7.70e-06	2	97	2	19669938
Pubmed	Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.	ATG7 APC	7.70e-06	2	97	2	26214133
Pubmed	Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain.	REV3L POLQ	7.70e-06	2	97	2	32838755
Pubmed	Autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors.	ATG7 APC	7.70e-06	2	97	2	22546555
Pubmed	NLRC5 negatively regulates LTA-induced inflammation via TLR2/NF-κB and participates in TLR2-mediated allergic airway inflammation.	TLR2 NLRC5	7.70e-06	2	97	2	30945291
Pubmed	Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients.	APC KLF4	7.70e-06	2	97	2	10913614
Pubmed	KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.	APC KLF4	7.70e-06	2	97	2	26839262
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RAD51B ATG7 INPP4A UBN2 PCNX2 ARHGAP6 KMT2C FOXP4 ABCC8 NLRC5 PNPLA7 LRBA CTNND1 EPB41 EVI5L	1.58e-05	1489	97	15	28611215
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	DYNC2H1 APC KMT2C FOXP4 PDE12 PWP2 SUFU MGA	1.63e-05	398	97	8	35016035
Pubmed	EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability.	RAPGEF3 ABCC8	2.31e-05	3	97	2	23678128
Pubmed	Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis.	APC KLF4	2.31e-05	3	97	2	17671182
Pubmed	APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells.	APC CTNND1	2.31e-05	3	97	2	33237836
Pubmed	Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells.	ALK HSP90AA1	2.31e-05	3	97	2	24952482
Pubmed	Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.	APC NLRC5	2.31e-05	3	97	2	35230972
Pubmed	An improved electronic microarray-based diagnostic assay for identification of MEFV mutations.	F5 MEFV	2.31e-05	3	97	2	15146467
Pubmed	SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.	BIRC3 KLF4	2.31e-05	3	97	2	37243389
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	TPR PIGS FAM91A1 STEAP3 ARPIN LRBA CTNND1 EPB41	3.84e-05	449	97	8	31732153
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	REV3L UBN2 MDN1 POLQ MGA KAT14	3.85e-05	222	97	6	37071664
Pubmed	Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis.	ATG7 TLR2	4.60e-05	4	97	2	26735693
Pubmed	KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin.	APC KLF4	4.60e-05	4	97	2	19901072
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	NLRP11 DNHD1 TPR MDN1 LRBA TNPO3	5.16e-05	234	97	6	36243803
Pubmed	Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex.	NINL CDC20	7.66e-05	5	97	2	17403670
Pubmed	Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor.	TPR CDC20	7.66e-05	5	97	2	24581499
Pubmed	Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.	APC CLOCK	7.66e-05	5	97	2	19106159
Pubmed	Expression and interaction of different catenins in colorectal carcinoma cells.	APC CTNND1	7.66e-05	5	97	2	11712088
Pubmed	Generation and Validation of miR-142 Knock Out Mice.	TSPOAP1 APC	7.66e-05	5	97	2	26327117
Pubmed	Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells.	KLF4 CRYAB	7.66e-05	5	97	2	21600198
Pubmed	Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.	APC CDC20	7.66e-05	5	97	2	9811605
Pubmed	Multiple cadherins are expressed in human fibroblasts.	PCDHGB4 DCHS1	7.66e-05	5	97	2	9199196
Pubmed	The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.	APC CTNND1	7.66e-05	5	97	2	7651399
Pubmed	The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C.	TPR CDC20	7.66e-05	5	97	2	31588029
Pubmed	Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts.	DYNC2H1 SUFU	7.66e-05	5	97	2	18488998
Pubmed	X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.	BIRC3 HSP90AA1	1.15e-04	6	97	2	19011619
Pubmed	Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins.	REV3L CDC20	1.15e-04	6	97	2	20088965
Pubmed	The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.	APC CDC20	1.15e-04	6	97	2	9637688
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TPR REV3L CRYAB FOXP4 MDN1 ASXL2 CTNND1 SUFU MGA HSP90AA1	1.43e-04	857	97	10	25609649
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	CLOCK FOXP4 MDN1 MAGEC1 CTNND1 TNPO3	1.44e-04	282	97	6	23667531
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TPR UBN2 KMT2C ARPIN LRBA CTNND1 MGA EPB41	1.55e-04	549	97	8	38280479
Pubmed	Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.	ALK HSP90AA1	1.60e-04	7	97	2	11888936
Pubmed	ENU mutagenesis in mice identifies candidate genes for hypogonadism.	RXFP2 BICC1	1.60e-04	7	97	2	22258617
Pubmed	Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.	APC KLF4	1.60e-04	7	97	2	24204315
Pubmed	A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.	ATG7 HSP90AA1	1.60e-04	7	97	2	27742708
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	TBC1D9B DDIAS MDN1 CTNND1 TNPO3 HSP90AA1	1.61e-04	288	97	6	23383273
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	CLOCK MDN1 MTMR3 CTNND1	2.11e-04	104	97	4	9205841
Pubmed	Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts.	CRYAB CTNND1	2.13e-04	8	97	2	35874813
Pubmed	Functional dissection of Rab GTPases involved in primary cilium formation.	TBC1D9B TBC1D8 EVI5L	2.39e-04	43	97	3	17646400
Pubmed	Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.	TBC1D9B TBC1D8 EVI5L	2.39e-04	43	97	3	19077034
Pubmed	A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.	APC TLR2	2.74e-04	9	97	2	25362351
Pubmed	Lack of association between genetic variation in 9 innate immunity genes and baseline CRP levels.	MEFV TLR2	2.74e-04	9	97	2	16907704
Pubmed	Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.	ATG7 TLR2	2.74e-04	9	97	2	18097414
Pubmed	SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.	APC CTNND1	2.74e-04	9	97	2	19170756
Pubmed	Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.	INPP4A CTNND1 EPB41	3.12e-04	47	97	3	32253237
Pubmed	Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.	KMT2C CTNND1	3.41e-04	10	97	2	22421440
Pubmed	Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.	SMYD4 NINL KAT14	3.53e-04	49	97	3	24652767
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	TPR FAM91A1 LRBA CTNND1 EPB41	3.58e-04	216	97	5	31519766
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	FAM91A1 TBC1D8 STEAP3 LRBA CTNND1 EPB41	3.85e-04	339	97	6	37232246
Pubmed	Hsp and chaperone distribution during endochondral bone development in mouse embryo.	CRYAB HSP90AA1	4.17e-04	11	97	2	9880236
Pubmed	Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.	APC TLR2	4.17e-04	11	97	2	23034650
Pubmed	Interaction network of human early embryonic transcription factors.	UBN2 KMT2C FOXP4 ASXL2 MGA KAT14	4.63e-04	351	97	6	38297188
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	TPR CTNND1 EPB41	5.52e-04	57	97	3	38223760
Pubmed	A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.	CLOCK RAD9A	5.89e-04	13	97	2	21659603
Pubmed	HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.	APC RNF146	5.89e-04	13	97	2	23277359
Pubmed	Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.	CRYAB HSP90AA1	5.89e-04	13	97	2	17661394
Pubmed	New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.	CRYAB EPB41	5.89e-04	13	97	2	16368544
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	KLF4 KMT2C HSP90AA1	6.73e-04	61	97	3	20305087
Pubmed	Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.	REV3L RFXANK	6.85e-04	14	97	2	15964851
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	DYNC2H1 PIGS B3GAT3 TBC1D8 INTS5 MDN1 STEAP3 LRBA BICC1 CAVIN2	7.65e-04	1061	97	10	33845483
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	TPR APC FAM91A1 CTNND1 EPB41	7.72e-04	256	97	5	33397691
Pubmed	CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.	SMG1 HSP90AA1	7.89e-04	15	97	2	20864032
Pubmed	Identification of potential protein interactors of Lrrk2.	MDN1 HSP90AA1	7.89e-04	15	97	2	17400507
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TPR APC TBC1D8 ARPIN LRBA CTNND1 EPB41 HSP90AA1	8.35e-04	708	97	8	39231216
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TPR APC FAM91A1 KLF4 UBN2 KMT2C RXFP2 ASXL2 MGA BICC1	9.01e-04	1084	97	10	11544199
Pubmed	The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.	REV3L CDC20	9.01e-04	16	97	2	23463509
Pubmed	Rapid and Integrative Discovery of Retina Regulatory Molecules.	ABCA13 RAD9A	9.01e-04	16	97	2	30157441
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	SMG1 TSPOAP1 ABCA13 LRRC32 CRYAB TBC1D8 NLRC5	9.17e-04	552	97	7	10737800
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	SMG1 APC FAM91A1 TBC1D8 LRBA CTNND1 TARBP1 CAVIN2	9.22e-04	719	97	8	35337019
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	APC FAM91A1 KLF4 UBN2 ATAD2 B3GAT3 KMT2C INTS5 MDN1 TRIM56 PWP2 EPB41	9.40e-04	1497	97	12	31527615
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KLF4 UBN2 CLOCK KMT2C MLXIPL INTS5 MDN1 RFXANK ASXL2 MGA KAT14	9.67e-04	1294	97	11	30804502
Pubmed	Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.	DCHS1 SUFU	1.02e-03	17	97	2	32155439
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	APC ALK HSP90AA1	1.05e-03	71	97	3	28319113
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	TPR FAM91A1 STEAP3 ARPIN LRBA EPB41 HSP90AA1	1.08e-03	568	97	7	37774976
Pubmed	Genome-wide association of mood-incongruent psychotic bipolar disorder.	INPP4A LRBA	1.14e-03	18	97	2	23092984
Pubmed	A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.	CRYAB HSP90AA1	1.14e-03	18	97	2	16049941
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TPR INPP4A APC LRBA MGA KAT14	1.14e-03	418	97	6	34709266
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	TPR INPP4A CYB561D2 ATAD2 LMAN1L KMT2C MLXIPL TRIM56 MGA KAT14 CAVIN2	1.18e-03	1327	97	11	32694731
Pubmed	Functional proteomics mapping of a human signaling pathway.	SMG1 DOCK8 INPP4A PHACTR3 ASXL2 MGA TNPO3	1.36e-03	591	97	7	15231748
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C ASXL2	1.42e-03	20	97	2	29785026
Pubmed	E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.	APC CTNND1	1.42e-03	20	97	2	7806582
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	MDN1 MGA HSP90AA1	1.43e-03	79	97	3	26446488
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	APC FAM91A1 STEAP3 LRBA CTNND1 MGA EPB41 HSP90AA1	1.51e-03	777	97	8	35844135
Pubmed	Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.	DYNC2H1 NAV3	1.56e-03	21	97	2	24057671
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	RAD51B CRYAB MDN1 MGA CAVIN2 RAD9A	1.72e-03	453	97	6	29656893
Pubmed	Role of β-catenin in development of bile ducts.	APC BICC1	1.87e-03	23	97	2	26856660
Pubmed	Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.	ATG7 HSP90AA1	1.87e-03	23	97	2	32597834
Pubmed	The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis.	F5 TLR2	1.87e-03	23	97	2	20207250
Interaction	C3orf18 interactions	SMG1 DYNC2H1 FAM91A1 MDN1 LRBA TARBP1 TNPO3	1.11e-06	115	94	7	int:C3orf18
Interaction	GYPA interactions	SMG1 DYNC2H1 INTS5 PWP2 LRBA TARBP1 TNPO3	1.73e-05	174	94	7	int:GYPA
Coexpression	LAKE_ADULT_KIDNEY_C15_CONNECTING_TUBULE	RAD51B KANSL1L DYNC2H1 ARHGAP6 KMT2C LRBA BICC1	3.49e-06	171	97	7	M39234
ToppCell	Adult-Mesenchymal-chondrocyte-D175\|Adult / Lineage, Cell type, age group and donor	ZCCHC24 ARHGAP6 ABCC8 NAV3 NEURL1B BICC1	1.85e-06	168	97	6	14071b961c9bdb54a8259b12a88237b802cbde36
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	KANSL1L DOCK8 ABCA13 KHDRBS2 MLXIPL BICC1	3.13e-06	184	97	6	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BIRC3 CASTOR2 TBC1D8 FOXP4 NLRC5 ARPIN	3.23e-06	185	97	6	19fa853f6f746ccf232a343b3c9c7a5e55800409
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 REV3L KMT2C MLXIPL ABCC8 MGA	4.37e-06	195	97	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 REV3L KMT2C MLXIPL ABCC8 MGA	4.37e-06	195	97	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	droplet-Lung-nan-3m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAD51B PIGB TSPOAP1 ARPIN POLQ	2.07e-05	152	97	5	77b319f594d5e4df29034bbf69c7490076f89dd3
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRYAB LMAN1L ARHGAP6 ALK BAIAP2L2	2.41e-05	157	97	5	516903469756c5fabfdf56d7bd59b3bdd7b44e39
ToppCell	Fetal_29-31_weeks-Immune-mast_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NRIP2 CYB561D2 BIRC3 IL18RAP DBNDD1	2.49e-05	158	97	5	0c27c475289c70b17b6a66fc71f628511c5f0ae1
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KHDRBS2 MLXIPL TLR2 NEURL1B CAVIN2	2.72e-05	161	97	5	8ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCell	AT1_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	KHDRBS2 DBNDD1 PHACTR3 BICC1 CAVIN2	2.81e-05	162	97	5	ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRYAB LMAN1L ARHGAP6 ALK BAIAP2L2	2.98e-05	164	97	5	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAD51B TSPOAP1 TBC1D8 NLRC5 ARPIN	3.06e-05	165	97	5	c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP2 DOCK8 NINL BAIAP2L2 BICC1	3.53e-05	170	97	5	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 INPP4A IL18RAP DBNDD1 PNPLA7	3.95e-05	174	97	5	ccc79febfcf588d8294ffc712338be96de8a5033
ToppCell	368C-Endothelial_cells-Endothelial-D\|368C / Donor, Lineage, Cell class and subclass (all cells)	LRRC32 KLF4 RAPGEF3 ABCC8 CAVIN2	4.06e-05	175	97	5	c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell	368C-Endothelial_cells-Endothelial-D-\|368C / Donor, Lineage, Cell class and subclass (all cells)	LRRC32 KLF4 RAPGEF3 ABCC8 CAVIN2	4.06e-05	175	97	5	ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP2 DOCK8 NINL BAIAP2L2 BICC1	4.06e-05	175	97	5	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	ZCCHC24 TSPOAP1 MDN1 PHACTR3 MTMR3	4.28e-05	177	97	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	facs-Lung-EPCAM-24m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 CASTOR2 TBC1D8 FOXP4 NLRC5	4.52e-05	179	97	5	51872338e54c5f3e42ca9f1c4cf1e8b0cb84afcc
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 CASTOR2 TBC1D8 FOXP4 NLRC5	4.52e-05	179	97	5	1b979e0203a2ddfe98bf6c2c80c4af1ba437a80f
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KLF4 RAPGEF3 NAV3 NEURL1B CAVIN2	5.02e-05	183	97	5	c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR SMG1 DOCK8 APC KLF4	5.15e-05	184	97	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TPR SMG1 APC ARHGAP6 ASXL2	5.42e-05	186	97	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATAD2 DDIAS TLR2 CDC20 POLQ	5.56e-05	187	97	5	73931a5ea73799095daff100b5f18853c57c74dc
ToppCell	droplet-Marrow-nan-3m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATAD2 NINL STEAP3 POLQ SAMD14	5.85e-05	189	97	5	8a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK8 F5 MEFV TLR2 RXFP2	5.99e-05	190	97	5	b7ce76931edc6734b80ddbb2fca23b098a8c1352
ToppCell	droplet-Pancreas-PANCREAS-30m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC32 KLF4 RAPGEF3 DCHS1 CAVIN2	6.15e-05	191	97	5	471205494b91be69926dc8159376132bcea0d9b5
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KLF4 TBC1D8 TLR2 ARPIN CAVIN2	6.30e-05	192	97	5	e24a8856ef01ccf69a5e968bd409f9b84befa91e
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZCCHC24 LRRC32 KLF4 NEURL1B CAVIN2	6.46e-05	193	97	5	daefbfd3a3dd1351fbe94b9abfd807db44d56c24
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP6 MLXIPL NINL LRBA BICC1	6.46e-05	193	97	5	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KANSL1L ARHGAP6 NINL LRBA BICC1	6.46e-05	193	97	5	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	LA\|World / Chamber and Cluster_Paper	PCNX2 LMAN1L ARHGAP6 MLXIPL BICC1	6.46e-05	193	97	5	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KANSL1L ARHGAP6 NINL LRBA BICC1	6.61e-05	194	97	5	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KANSL1L ARHGAP6 NINL LRBA BICC1	6.78e-05	195	97	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC32 RAPGEF3 DCHS1 NEURL1B CAVIN2	6.94e-05	196	97	5	d5d3028fcbfa251a206d17ec33b3b313968f9d79
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC32 RAPGEF3 ABCC8 NEURL1B SAMD14	6.94e-05	196	97	5	f0b106078212be1d0938f545707a004a1e830857
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-DC2\|lymph-node_spleen / Manually curated celltypes from each tissue	MEFV TBC1D8 TLR2 ARPIN CTNND1	6.94e-05	196	97	5	9666b5380e2b2a3c3b56a8c769817a1df8820ed6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZCCHC24 LRRC32 DCHS1 NEURL1B CAVIN2	6.94e-05	196	97	5	95c5b8fd4ebfae1f42de9b1475c1161d4a80e515
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KANSL1L ARHGAP6 NINL LRBA BICC1	6.94e-05	196	97	5	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KANSL1L ARHGAP6 NINL LRBA BICC1	6.94e-05	196	97	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	LRRC32 ATAD2 ARHGAP6 ABCC8 NAV3	7.11e-05	197	97	5	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	ATAD2 DDIAS DBNDD1 CDC20 POLQ	7.28e-05	198	97	5	880f9817f5145f10f29fc05c5866090433532fe2
ToppCell	10x3'2.3-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRRC32 DCHS1 CTNND1 NEURL1B CAVIN2	7.28e-05	198	97	5	2630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRRC32 DCHS1 CTNND1 NEURL1B CAVIN2	7.28e-05	198	97	5	1e83bec16dcd60460422625f89952ff506d6be51
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC32 RAPGEF3 ABCC8 NEURL1B CAVIN2	7.28e-05	198	97	5	71ee440b1ac566db63d0b415c50a0ad064d14f15
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZCCHC24 LRRC32 DCHS1 NEURL1B CAVIN2	7.28e-05	198	97	5	259fbcc0f2ac281a3e4d693de45b986fe5e24841
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	ATAD2 DDIAS NEURL1B CDC20 POLQ	7.46e-05	199	97	5	a99516a5760f49a69b0fe45a9b2316e393252966
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-Treg\|Leuk-UTI / Disease, condition lineage and cell class	BIRC3 MEI1 F5 SAMD14 EPB41	7.46e-05	199	97	5	100f45e04f284551b29ef0406476bdc347ddbf7e
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CYB561D2 IL18RAP ASXL2 HSP90AA1	7.62e-05	103	97	4	e28236a064a7c86e99e7e2edb1eb777f6034a9b4
ToppCell	Transverse-Macrophage-Macrophage\|Transverse / Region, Cell class and subclass	KLF4 MEFV TLR2 ARPIN CTNND1	7.64e-05	200	97	5	17548806ba38008050244151d1216c69ef8a8310
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MEI1 ARHGAP6 BAIAP2L2 CAVIN2 EVI5L	7.64e-05	200	97	5	326cae37cacd94b423a6ac8873ea56c5abaf0a0b
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TPR SMG1 DOCK8 KMT2C EPB41	7.64e-05	200	97	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	distal-Endothelial-Vein-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LRRC32 BIRC3 ABCC8 NEURL1B CAVIN2	7.64e-05	200	97	5	ff88d28162e0231d5dac0e0c6bec98fa8da58a23
ToppCell	Transverse-(6)_Macrophage-(60)_Macrophage\|Transverse / shred on region, Cell_type, and subtype	KLF4 MEFV TLR2 ARPIN CTNND1	7.64e-05	200	97	5	2be675684a2958ea609939bb45248bede78a26bc
ToppCell	(60)_Macrophage\|World / shred on Cell_type and subtype	KLF4 MEFV TLR2 ARPIN CTNND1	8.38e-05	204	97	5	06d0cb306f1ad0014d81f8228868938e48c2bcf3
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Cortical_subplate_interneuron)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LMAN1L ALK SPATC1L	1.88e-04	51	97	3	73a6c4354f2f4a7de95d15467b1249f4c57b441e
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Cortical_subplate_interneuron)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LMAN1L ALK SPATC1L	1.88e-04	51	97	3	650d288bd1816b3798025c9fa4cea2f6db639a55
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NRIP2 ARHGAP6 DCHS1 ALK	2.23e-04	136	97	4	e3a2425ba5ef538dbacab1479e682837ae42a888
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular\|TCGA-Stomach / Sample_Type by Project: Shred V9	F5 FOXP4 POLQ TARBP1	2.35e-04	138	97	4	93497c0a5d5e54006653b2dedc7a7041e1a613e6
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC75B ATAD2 DDIAS TARBP1	2.49e-04	140	97	4	e442c46979d725ec82f525a001c46d971fcade4d
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-8\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	KLF4 MEFV RXFP2 PHACTR3	3.15e-04	149	97	4	0c18acfc5f0a9dd25ee5c38f97498b3278e65b42
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	SMG1 NLRC5 LRBA EPB41	3.32e-04	151	97	4	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	DOCK8 BIRC3 CMTR2 EPB41	3.32e-04	151	97	4	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	DOCK8 BIRC3 CMTR2 EPB41	3.32e-04	151	97	4	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-stem_cells_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	KLF4 RAPGEF3 ASXL2 BICC1	3.40e-04	152	97	4	375c9ef88c7703a002e868645a722c35e046ef1e
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRYAB ARHGAP6 ALK BAIAP2L2	3.40e-04	152	97	4	fed80b467ec9e30c7f98bed6cc4f8c583b715e9e
ToppCell	Leuk-UTI-Lymphocyte-T_NK-Treg\|Leuk-UTI / Disease, Lineage and Cell Type	BIRC3 F5 SAMD14 EPB41	3.48e-04	153	97	4	b24c693b142206d13b29c96faa7f79a1a22bc2ef
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TPR BIRC3 F5 EPB41	3.48e-04	153	97	4	7480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	BIRC3 F5 TBC1D8 NAV3	3.57e-04	154	97	4	b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TPR BIRC3 F5 EPB41	3.75e-04	156	97	4	53ded973358e3e48054130131e959f0d1f4ef60f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CASTOR2 F5 RAPGEF3 PHACTR3	3.94e-04	158	97	4	e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CASTOR2 F5 RAPGEF3 PHACTR3	3.94e-04	158	97	4	d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell	severe_COVID-19-NK_CD56bright\|severe_COVID-19 / disease group, cell group and cell class (v2)	IL18RAP SLC2A10 NINL BAIAP2L2	3.94e-04	158	97	4	c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCell	mild_COVID-19_(asymptomatic)-B_cell\|World / disease group, cell group and cell class (v2)	ARHGAP6 PWP2 NEURL1B CAVIN2	3.94e-04	158	97	4	afa8fa21c39c2192c1e23a4660011d63d58b733f
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP6 NAV3 PNPLA7 BICC1	3.94e-04	158	97	4	e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	KANSL1L DOCK8 MLXIPL MGA	4.32e-04	162	97	4	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRYAB ARHGAP6 ALK BAIAP2L2	4.43e-04	163	97	4	bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRYAB LMAN1L ALK BAIAP2L2	4.43e-04	163	97	4	8d17f44faf0549fe71a9a45f811f50d767275414
ToppCell	mild_COVID-19_(asymptomatic)-B_cell\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	ARHGAP6 PWP2 NEURL1B CMTR2	4.53e-04	164	97	4	e4d43af7eb04d55328791b554bdf3a7ce6818027
ToppCell	droplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAD51B TSPOAP1 NLRC5 ARPIN	4.53e-04	164	97	4	78de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	NEURL1B POLQ ALK BICC1	4.63e-04	165	97	4	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	F5 TBC1D8 DBNDD1 ABCC8	4.74e-04	166	97	4	eb9c81fa7573de7aff6670e7dad313f02129809f
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 UBN2 MLXIPL ABCC8	4.74e-04	166	97	4	66026988509e39e41274fa0de738383219e8ff30
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 SLC2A10 NAV3 SPATC1L	4.85e-04	167	97	4	961e722442d786ab15d1e490941d2be265a9057a
ToppCell	COVID-19_Moderate-Treg\|COVID-19_Moderate / disease group, cell group and cell class	LRRC32 BIRC3 F5 EPB41	4.85e-04	167	97	4	4ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCell	facs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 SLC2A10 NAV3 SPATC1L	4.85e-04	167	97	4	3760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell	CTRL-Myeloid-Monocyte\|CTRL / Disease state, Lineage and Cell class	BIRC3 F5 MEFV TLR2	4.96e-04	168	97	4	13dca90c7b811e4d5e8fa44f5e892e29be9787a6
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRYAB TBC1D8 MLXIPL PHACTR3	4.96e-04	168	97	4	4e2e4c88ada772e9ba6e72c9ae3a05c063e93318
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC32 SLC2A10 DCHS1 CAVIN2	4.96e-04	168	97	4	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRYAB TBC1D8 MLXIPL PHACTR3	4.96e-04	168	97	4	ee4dab089adef2f47a9d39d91934523331a8b81c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC32 KLF4 DBNDD1 NAV3	5.07e-04	169	97	4	db71386408053171363fa8411f5a36c2192487e0
ToppCell	COVID-19_Moderate-Treg\|World / disease group, cell group and cell class	LRRC32 BIRC3 F5 EPB41	5.07e-04	169	97	4	27ad11239559b025bef582f89b2a83501d9d3993
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	F5 MLXIPL STEAP3 POLQ	5.19e-04	170	97	4	7534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC32 RAPGEF3 NAV3 DCHS1	5.19e-04	170	97	4	1a568efcff9c39b3f709b55a05d24710450a2657
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC32 RAPGEF3 NAV3 DCHS1	5.19e-04	170	97	4	66d41d794790e621d72ac37af995510537103c9c
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T\|Lung / Manually curated celltypes from each tissue	RAD51B NEURL1B CDC20 POLQ	5.30e-04	171	97	4	976361f67dd725870e0513ae7a92f2dcaee17148
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 TBC1D8 DDIAS ABCC8	5.30e-04	171	97	4	913bae728b5e653771a27c79a309eb023699f1d0
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 TBC1D8 DDIAS ABCC8	5.30e-04	171	97	4	f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC32 F5 ARHGAP6 SAMD14	5.42e-04	172	97	4	e39ea2f4edbf36ebf9604fa6f9349081859c596c
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC32 F5 ARHGAP6 SAMD14	5.42e-04	172	97	4	875ea290840e835952623b905eb610f3c71456d2
Disease	nephrotic syndrome type 20 (implicated_via_orthology)	TBC1D9B TBC1D8	6.13e-05	4	95	2	DOID:0070357 (implicated_via_orthology)
Disease	Ki-1+ Anaplastic Large Cell Lymphoma	ALK HSP90AA1	6.13e-05	4	95	2	C0206180
Disease	Childhood Medulloblastoma	APC SMYD4 SUFU	3.63e-04	43	95	3	C0278510
Disease	Melanotic medulloblastoma	APC SMYD4 SUFU	3.63e-04	43	95	3	C1275668
Disease	Medullomyoblastoma	APC SMYD4 SUFU	3.63e-04	43	95	3	C0205833
Disease	Desmoplastic Medulloblastoma	APC SMYD4 SUFU	3.63e-04	43	95	3	C0751291
Disease	Adult Medulloblastoma	APC SMYD4 SUFU	3.63e-04	43	95	3	C0278876
Disease	medulloblastoma (is_implicated_in)	APC SUFU	4.54e-04	10	95	2	DOID:0050902 (is_implicated_in)
Disease	Medulloblastoma	APC SMYD4 SUFU	5.68e-04	50	95	3	C0025149
Disease	reticulocyte measurement	RAD51B ZCCHC24 TBC1D8 MLXIPL FOXP4 MTMR3 PCDHGB4 ASXL2 ADGRD2 CTNND1 EPB41	5.74e-04	1053	95	11	EFO_0010700
Disease	Malignant neoplasm of breast	RAD51B TBC1D9B DYNC2H1 PIGS SLC2A10 FOXP4 MTMR3 NLRC5 LRBA ALK HSP90AA1	6.76e-04	1074	95	11	C0006142
Disease	Sarcomatoid Renal Cell Carcinoma	DNHD1 CRYAB NAV3 ALK	7.93e-04	128	95	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	DNHD1 CRYAB NAV3 ALK	7.93e-04	128	95	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	DNHD1 CRYAB NAV3 ALK	7.93e-04	128	95	4	C1266044
Disease	Papillary Renal Cell Carcinoma	DNHD1 CRYAB NAV3 ALK	7.93e-04	128	95	4	C1306837
Disease	Renal Cell Carcinoma	DNHD1 CRYAB NAV3 ALK	7.93e-04	128	95	4	C0007134
Disease	triglycerides to total lipids in large HDL percentage	MLXIPL RNF146 NLRC5	9.69e-04	60	95	3	EFO_0022330
Disease	Polyposis, Adenomatous Intestinal	APC F5	1.20e-03	16	95	2	C2713442
Disease	Familial Intestinal Polyposis	APC F5	1.20e-03	16	95	2	C2713443
Disease	Adenomatous Polyposis Coli	APC F5	1.35e-03	17	95	2	C0032580
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 CRYAB NAV3 ALK	1.36e-03	148	95	4	C0279702
Disease	creatinine measurement	INPP4A KLF4 TBC1D8 MTMR3 PCDHGB4 ASXL2 PNPLA7 CTNND1 SUFU HSP90AA1	1.38e-03	995	95	10	EFO_0004518
Disease	estrogen-receptor negative breast cancer	RAD51B FAM91A1 CASTOR2	1.58e-03	71	95	3	EFO_1000650
Disease	Meningioma	KLF4 SUFU	1.69e-03	19	95	2	C0025286
Disease	pentachlorophenol measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022071
Disease	parathion measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022070
Disease	potassium chromate measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022072
Disease	mercuric chloride measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022068
Disease	heptachlor epoxide measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022067
Disease	methoxychlor measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022052
Disease	azinphos methyl measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022055
Disease	aldrin measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022054
Disease	dicofol measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022060
Disease	disulfoton measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022062
Disease	dieldrin measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022061
Disease	endrin measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022064
Disease	endosulfan measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022063
Disease	heptachlor measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022066
Disease	ethion measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022065
Disease	chlorpyrifos measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022057
Disease	cadmium chloride measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022056
Disease	diazinon measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022059
Disease	dibutyl phthalate measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0022058
Disease	environmental exposure measurement	F5 PHACTR3 CDC20	1.71e-03	73	95	3	EFO_0008360
Disease	DDT metabolite measurement	F5 PHACTR3 CDC20	1.78e-03	74	95	3	EFO_0007886
Disease	waist-hip ratio	RAD51B ATG7 DYNC2H1 CLOCK MEFV MLXIPL RAPGEF3 ABCC8 RNF146 NAV3 NEURL1B	1.95e-03	1226	95	11	EFO_0004343
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	F5 TRIM56	2.07e-03	21	95	2	EFO_0004286, EFO_0004792
Disease	citrate measurement	MLXIPL PHACTR3 ALK	2.14e-03	79	95	3	EFO_0010114
Disease	progression free survival, ovarian serous carcinoma	ABCA13 MGA	2.27e-03	22	95	2	EFO_0004920, EFO_1001516
Disease	lung disease (is_implicated_in)	MEFV TLR2	2.27e-03	22	95	2	DOID:850 (is_implicated_in)
Disease	portal hypertension (biomarker_via_orthology)	F5 HSP90AA1	2.27e-03	22	95	2	DOID:10762 (biomarker_via_orthology)
Disease	triacylglycerol 56:4 measurement	PHACTR3 MAGEC1	2.70e-03	24	95	2	EFO_0010431
Disease	hepatocellular carcinoma (is_implicated_in)	APC BIRC3 KLF4 TLR2	2.82e-03	181	95	4	DOID:684 (is_implicated_in)
Disease	triacylglycerol 56:5 measurement	MAGEC1 ALK	3.17e-03	26	95	2	EFO_0010432
Disease	atopic dermatitis (is_implicated_in)	DOCK8 TLR2	3.17e-03	26	95	2	DOID:3310 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLELPSSEHLSVADA	CASTOR3	71	Q8NAP1
LSLARHLDEDSLPSS	EVI5L	721	Q96CN4
TDPSLDLHSLSSAET	EPB41	141	P11171
FDSTAPRGHLESSLL	B3GAT3	271	O94766
FESDLHSLLQLDAPI	CDC20	6	Q12834
LTFLSSDHLSLPESI	CAPS2	371	Q9BXY5
LELPSSEHLSVADAT	CASTOR2	61	A6NHX0
ELTTFSCSLLHDGDP	CMTR2	606	Q8IYT2
SFHSLPSLTEDILNI	ABCA13	756	Q86UQ4
ASYPHLLEQLLSTSD	BIRC3	336	Q13489
SLDLSSDFLSLEHIG	ATAD2	21	Q6PL18
LALTESLTPDHTVAF	ARPIN	126	Q7Z6K5
LFLLEDLHLATSDPE	DNHD1	2451	Q96M86
LHSTDRLLSDPELSA	BICC1	671	Q9H694
SEPLLSSALNTHELS	ASXL2	461	Q76L83
AFLSTTLSALDEALH	RAD51B	81	O15315
LDGHFVLATLSDTDS	RAD9A	256	Q99638
LADLSHSSGPELSFL	TSPOAP1	731	O95153
HLLESDLFPTSTSLS	CRYAB	31	P02511
LEFSLACSELHTPSL	INPP4A	46	Q96PE3
PLSATATLHLVFADS	PCDHGB4	651	Q9UN71
SELFSLHPHSGELLT	DCHS1	1261	Q96JQ0
PSEATSSLSEEHLAL	IL18RAP	421	O95256
SSLSEEHLALSLFPD	IL18RAP	426	O95256
SELDSSFHSVLSLPS	KANSL1L	626	A0AUZ9
DLLDLDFILSNSLTH	KLF4	101	O43474
TLSHNTLFGEAPSDL	MDN1	3691	Q9NU22
HPSESLDTDSLLIAV	KMT2C	591	Q8NEZ4
QSPLEGEDSLSSLHF	MAGEC1	696	O60732
SISPLLLHLEDDDFS	MGA	2896	Q8IWI9
PTDLHAHFLADALTS	NLRP11	366	P59045
SLLFLPAGTDETATH	SLC2A10	181	O95528
DHDVLSFLTFSLSEP	LMAN1L	241	Q9HAT1
SILDIHTEPSFSSLL	FAM91A1	781	Q658Y4
SYPLRGSHSLDDLLD	BAIAP2L2	421	Q6UXY1
LPHLSLSQYDLLETD	PCNX2	256	A6NKB5
EPKLSLSFALADGSH	PDE12	46	Q6L8Q7
PSSHSDIEELTDSSL	NAV3	1726	Q8IVL0
ASHSATPSLLSEADL	KAT14	341	Q9H8E8
TSLAESHPSESDFSL	DDIAS	706	Q8IXT1
SLSLEAPRLHTASDL	PDZD3	11	Q86UT5
DLSFTGLSDELLHLL	LRRC75B	186	Q2VPJ9
LPLLSAATSATHELE	LRBA	1376	P50851
SASSLLPLSHDDVGA	FOXP4	596	Q8IVH2
SDHLLSTLEELVPYD	MEFV	6	O15553
LAAELSLLCSHEDPS	MROH9	171	Q5TGP6
VPLTAFALELEHALS	PNPLA7	741	Q6ZV29
LLFDLYLSPESDHDT	NLRC5	276	Q86WI3
PEFLFEHLSSSSEVL	MEI1	326	Q5TIA1
LTLSGAHDLSESELD	ARHGAP6	841	O43182
GAFLHTPLTELDLSS	LRRC32	461	Q14392
ETLDLSELFHPDTFL	DYNC2H1	4166	Q8NCM8
SSHSFLEDLTGLTLL	ATG7	671	O95352
VSAIHSLLSSHDLDP	DOCK8	1186	Q8NF50
PLSSVSSLEVHFDLL	DBNDD1	61	Q9H9R9
SSLSPADTLDIFADL	POLQ	621	O75417
SLDPSFVHASRLLAE	KHDRBS2	16	Q5VWX1
LATLAGELSHDSASP	EMILIN3	481	Q9NT22
LLSSGFSLEDPQTHA	HSP90AA1	671	P07900
TLHTVDLSSDDDLPH	CAVIN2	196	O95810
TEALLVFSPESSLLH	CYB561D2	61	O14569
SSHSYDDSTLPLIDR	CTNND1	861	O60716
SSLHPTSSSIDLELD	MTMR3	1176	Q13615
EVSALPATLDSLSIH	RFXANK	81	O14593
HTTLPEFLLLGFSDL	OR10P1	6	Q8NGE3
TSSELAFFDPSLLHL	PIGS	496	Q96S52
FLHKDSADLLPLDSL	NRIP2	91	Q9BQI9
SLDKPLSSAAHLDDA	PHACTR3	166	Q96KR7
DASLPTHLITFSILE	PIGB	491	Q92521
VSPEEHADFSSFLLL	TGIF2LX	206	Q8IUE1
IFLHSSSLLQPEDEL	SMYD4	36	Q8IYR2
LSPDLSHTTLSLDFS	F5	1276	P12259
ISPDLSHTTLSLDFS	F5	1321	P12259
SSLHALSSSLPDDLL	SMG1	781	Q96Q15
DLSSNTITELSPHLF	RXFP2	311	Q8WXD0
SPDASTSLEDSFAHL	RNF146	236	Q9NTX7
HTLSQSSDEFLDEPL	SAMD14	306	Q8IZD0
ESASAHLSDLAPLLL	INTS5	601	Q6P9B9
GLFSHEPALLLESST	NINL	261	Q9Y2I6
LDSSAFLSSDFLLPE	MLXIPL	366	Q9NP71
LEDLLCSHAPLSSED	SPATC1L	86	Q9H0A9
SSSEASPLASDLDLF	TBC1D9B	951	Q66K14
LDDTTQLPLLSHFAE	ABCC8	1191	Q09428
DHALLLSTTDVPASE	ALK	516	Q9UM73
LSPAEASSFLGLLEH	ADGRD2	401	Q7Z7M1
VLPDADTLLHFATES	APC	1481	P25054
STHLLESDSLTPEYL	CLOCK	171	O15516
HDPTETFLSDFLLTH	RAPGEF3	411	O95398
LDEDLSFHSPSLDLV	UBN2	756	Q6ZU65
SFHSPSLDLVSEALA	UBN2	761	Q6ZU65
DISHTLPIAASSSLD	WDR61	71	Q9GZS3
FSAELTLHSEVLSPE	REV3L	331	O60673
DKPLISLHLVDSDSS	STEAP3	6	Q658P3
IPLHASSLDDVSLAS	TPR	626	P12270
ELPEFNLIHSLSISD	PWP2	316	Q15269
LLFSDAVTDLASHPG	TBC1D8	516	O95759
SSPALLEADLRFHAT	NEURL1B	271	A8MQ27
SLESDSSTAIIPHEL	SUFU	346	Q9UMX1
YELPTDSHASLRDSL	TNPO3	76	Q9Y5L0
DLLSSYPDLAEVHAL	TTC37	411	Q6PGP7
DSLHAGPLESFLSSL	TARBP1	831	Q13395
IEEDSFSSLGSLEHL	TLR2	91	O60603
SSPSLLEALSSDFLA	TRIM56	6	Q9BRZ2
IADGLSSLTEHFSDL	ZCCHC24	101	Q8N2G6