Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

DNHD1 KIF13B MYH3 MYH7 IPO8 DYNC2H1 MYO1H TOR1A MCM5 CHD1 CHD7 ABCD1 HSP90AB2P SNRNP200

4.61e-076148814GO:0140657
GeneOntologyMolecularFunctionATP hydrolysis activity

KIF13B MYH3 MYH7 DYNC2H1 TOR1A MCM5 CHD1 CHD7 ABCD1 HSP90AB2P SNRNP200

3.74e-064418811GO:0016887
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNHD1 KIF13B MYH3 MYH7 DYNC2H1 MYO1H

1.37e-05118886GO:0003774
GeneOntologyMolecularFunctionmetallocarboxypeptidase activity

AGBL5 AGBL1 AGTPBP1

3.40e-0431883GO:0004181
GeneOntologyMolecularFunctiondolichyl-phosphate-mannose-protein mannosyltransferase activity

TMEM260 TMTC1

5.28e-048882GO:0004169
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

KIF13B MYH3 MYH7 DYNC2H1 TOR1A MCM5 CHD1 CHD7 ABCD1 HSP90AB2P SNRNP200

5.90e-047758811GO:0017111
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH3 MYH7 MYO1H

6.24e-0438883GO:0000146
GeneOntologyMolecularFunctionpyrophosphatase activity

KIF13B MYH3 MYH7 DYNC2H1 TOR1A MCM5 CHD1 CHD7 ABCD1 HSP90AB2P SNRNP200

1.13e-038398811GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

KIF13B MYH3 MYH7 DYNC2H1 TOR1A MCM5 CHD1 CHD7 ABCD1 HSP90AB2P SNRNP200

1.14e-038408811GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

KIF13B MYH3 MYH7 DYNC2H1 TOR1A MCM5 CHD1 CHD7 ABCD1 HSP90AB2P SNRNP200

1.14e-038408811GO:0016818
GeneOntologyMolecularFunctioncarboxypeptidase activity

AGBL5 AGBL1 AGTPBP1

1.32e-0349883GO:0004180
GeneOntologyMolecularFunctionexopeptidase activity

DPP7 AGBL5 AGBL1 AGTPBP1

1.42e-03110884GO:0008238
GeneOntologyBiologicalProcessC-terminal protein deglutamylation

AGBL5 AGBL1 AGTPBP1

1.49e-066883GO:0035609
GeneOntologyBiologicalProcessprotein side chain deglutamylation

AGBL5 AGBL1 AGTPBP1

1.49e-066883GO:0035610
GeneOntologyBiologicalProcessprotein deglutamylation

AGBL5 AGBL1 AGTPBP1

4.14e-068883GO:0035608
GeneOntologyBiologicalProcessC-terminal protein amino acid modification

AGBL5 AGBL1 AGTPBP1

6.92e-0519883GO:0018410
HumanPhenoKyphosis

MYH3 MYH7 NF1 IPO8 PIK3R2 MYO1H SYNE2 MED25 ANKRD11 TOR1A BAZ1B PRDM13 PLOD2 NSDHL

2.33e-055104114HP:0002808
HumanPhenoVentricular septal defect

FOCAD TMEM260 CACNA1C MYH3 MYH7 NF1 IPO8 PIK3R2 MED25 ANKRD11 BAZ1B PRDM13 CHD7 YARS1

2.33e-055104114HP:0001629
HumanPhenoAbnormal ventricular septum morphology

FOCAD TMEM260 CACNA1C MYH3 MYH7 NF1 IPO8 PIK3R2 MED25 ANKRD11 BAZ1B PRDM13 CHD7 YARS1

2.98e-055214114HP:0010438
HumanPhenoFunctional abnormality of male internal genitalia

FOCAD DNHD1 MYH3 NF1 IPO8 DYNC2H1 NEK10 RNF135 MED25 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 XPC ABCD1 AGBL5 PLOD2 SNRNP200 WDR62 BBS10

7.06e-0512694122HP:0000025
HumanPhenoAbnormal male reproductive system physiology

FOCAD DNHD1 MYH3 NF1 IPO8 DYNC2H1 NEK10 RNF135 MED25 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 XPC ABCD1 AGBL5 PLOD2 SNRNP200 WDR62 BBS10

1.24e-0413144122HP:0012874
HumanPhenoAbnormal branching pattern of the aortic arch

TMEM260 IPO8 PIK3R2 CHD7

1.25e-0433414HP:0011587
HumanPhenoMicrognathia

FOCAD CACNA1C MYH3 MYH7 NF1 IPO8 DYNC2H1 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 ABCD1 YARS1 WDR62 NSDHL

1.29e-048434117HP:0000347
HumanPhenoAplasia/Hypoplasia of the mandible

FOCAD CACNA1C MYH3 MYH7 NF1 IPO8 DYNC2H1 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 ABCD1 YARS1 WDR62 NSDHL

1.33e-048454117HP:0009118
HumanPhenoAbnormal testis morphology

FOCAD DNHD1 MYH3 NF1 IPO8 DYNC2H1 RNF135 MED25 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 XPC AGBL5 PLOD2 SNRNP200 WDR62 BBS10

1.48e-0411294120HP:0000035
HumanPhenoNon-obstructive azoospermia

FOCAD DNHD1 MYH3 NF1 IPO8 DYNC2H1 RNF135 MED25 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 XPC AGBL5 PLOD2 SNRNP200 WDR62 BBS10

1.53e-0411324120HP:0011961
HumanPhenoAbnormal male internal genitalia morphology

FOCAD DNHD1 MYH3 NF1 IPO8 DYNC2H1 RNF135 MED25 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 XPC ABCD1 AGBL5 PLOD2 SNRNP200 WDR62 BBS10

1.79e-0412434121HP:0000022
HumanPhenoAzoospermia

FOCAD DNHD1 MYH3 NF1 IPO8 DYNC2H1 RNF135 MED25 ANKRD11 TOR1A BAZ1B PRDM13 MCM5 CHD7 XPC AGBL5 PLOD2 SNRNP200 WDR62 BBS10

2.11e-0411574120HP:0000027
DomainARM-type_fold

FOCAD NF1 IPO8 IPO7 NEK10 MROH5 EFR3B AGBL1 AGTPBP1

2.59e-05339869IPR016024
DomainARM-like

NF1 IPO8 IPO7 NEK10 MROH5 EFR3B AGBL1 AGTPBP1

3.44e-05270868IPR011989
DomainCse1

IPO8 IPO7

6.27e-053862IPR013713
DomainCse1

IPO8 IPO7

6.27e-053862PF08506
DomainRasGAP_dom

NF1 PLXNB2 RASAL2

7.32e-0518863IPR001936
Domain-

NF1 IPO8 IPO7 NEK10 MROH5 EFR3B AGTPBP1

7.39e-052228671.25.10.10
DomainPeptidase_M14

AGBL5 AGBL1 AGTPBP1

1.56e-0423863PF00246
DomainPeptidase_M14

AGBL5 AGBL1 AGTPBP1

1.56e-0423863IPR000834
DomainRho_GTPase_activation_prot

NF1 PIK3R2 PLXNB2 RASAL2

7.28e-0488864IPR008936
DomainP-loop_NTPase

DNHD1 KIF13B MYH3 MYH7 DYNC2H1 TOR1A MCM5 CHD1 CHD7 ABCD1 SNRNP200

1.73e-038488611IPR027417
DomainRasGAP

NF1 RASAL2

1.84e-0314862SM00323
DomainDynein_HC_stalk

DNHD1 DYNC2H1

1.84e-0314862IPR024743
DomainDynein_heavy_dom-2

DNHD1 DYNC2H1

1.84e-0314862IPR013602
DomainDHC_N2

DNHD1 DYNC2H1

1.84e-0314862PF08393
DomainIMPORTIN_B_NT

IPO8 IPO7

1.84e-0314862PS50166
DomainMT

DNHD1 DYNC2H1

1.84e-0314862PF12777
DomainRasGAP_CS

NF1 RASAL2

1.84e-0314862IPR023152
DomainDHC_fam

DNHD1 DYNC2H1

2.12e-0315862IPR026983
DomainRasGAP

NF1 RASAL2

2.12e-0315862PF00616
DomainRAS_GTPASE_ACTIV_1

NF1 RASAL2

2.12e-0315862PS00509
DomainMyosin_N

MYH3 MYH7

2.12e-0315862PF02736
DomainIBN_N

IPO8 IPO7

2.12e-0315862PF03810
DomainRAS_GTPASE_ACTIV_2

NF1 RASAL2

2.12e-0315862PS50018
DomainDynein_heavy_dom

DNHD1 DYNC2H1

2.12e-0315862IPR004273
DomainMyosin_N

MYH3 MYH7

2.12e-0315862IPR004009
DomainDynein_heavy

DNHD1 DYNC2H1

2.12e-0315862PF03028
Domain-

PLXNB2 RASAL2

2.41e-03168621.10.506.10
DomainIBN_N

IPO8 IPO7

2.41e-0316862SM00913
DomainImportin-beta_N

IPO8 IPO7

2.72e-0317862IPR001494
DomainMyosin_tail_1

MYH3 MYH7

3.06e-0318862PF01576
DomainMyosin_tail

MYH3 MYH7

3.06e-0318862IPR002928
DomainMyosin-like_IQ_dom

MYH3 MYH7

3.41e-0319862IPR027401
Domain-

MYH3 MYH7

3.41e-03198624.10.270.10
DomainApc4_WD40_dom

COPA WDR62

3.77e-0320862IPR024977
DomainANAPC4_WD40

COPA WDR62

3.77e-0320862PF12894
DomainChromo_domain

CHD1 CHD7

5.42e-0324862IPR023780
DomainChromo

CHD1 CHD7

6.34e-0326862PF00385
DomainCHROMO_1

CHD1 CHD7

7.33e-0328862PS00598
DomainCHROMO_2

CHD1 CHD7

7.33e-0328862PS50013
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

IPO8 IPO7 UBR5 DYNC2H1 PIK3R2 MRPL37 SYNE2 EFR3B ANKRD11 TOR1A BAZ1B CHD1 NIBAN2 PLXNB2 PLOD2 SNRNP200 RASAL2 AGTPBP1 WDR62 NSDHL

7.01e-101487882033957083
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

MYH7 IPO8 IPO7 COPA UBR5 DYNC2H1 G3BP2 SYNE2 CPSF1 BAZ1B ABCD1 SNRNP200 INPP5J YARS1

6.58e-09754881435906200
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

CYB5B NF1 IPO7 DYNC2H1 G3BP2 MRPL37 SYNE2 CHD7 XPC INTS3 RASAL2 NSDHL

7.56e-08638881231182584
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 NF1 IPO8 IPO7 COPA DYNC2H1 G3BP2 MRPL37 CPSF1 BAZ1B MCM5 CHD1 SNRNP200 YARS1 RASAL2 PCYOX1 NSDHL

9.16e-081425881730948266
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

NF1 IPO7 COPA G3BP2 CPSF1 MCM5 EXOC1 CHD7 NIBAN2 INTS3 SNRNP200

2.62e-07582881120467437
Pubmed

A novel subfamily of mouse cytosolic carboxypeptidases.

AGBL5 AGBL1 AGTPBP1

3.11e-07688317244818
Pubmed

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.

AGBL5 AGBL1 AGTPBP1

3.11e-07688325103237
Pubmed

A family of protein-deglutamylating enzymes associated with neurodegeneration.

AGBL5 AGBL1 AGTPBP1

5.44e-07788321074048
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

KIF13B G3BP2 SYNE2 CHD7 ABCD1 HSP90AB2P PLOD2

7.24e-0719788720811636
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NF1 IPO7 COPA UBR5 SYNE2 CPSF1 BAZ1B MCM5 CHD1 CHD7 SNRNP200

8.13e-07653881122586326
Pubmed

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.

AGBL5 AGBL1 AGTPBP1

1.30e-06988326829768
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

MYH7 COPA DYNC2H1 CYP27C1 SYNE2 ASAP3 BAZ1B EXOC1

1.67e-0632288826514267
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

IPO7 COPA UBR5 G3BP2 CHD1 SNRNP200 YARS1

2.09e-0623188736597993
Pubmed

IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.

AGBL5 AGBL1 AGTPBP1

3.39e-061288328794449
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NF1 COPA CPSF1 BAZ1B CHD7 XPC NIBAN2 INTS3 SNRNP200 AGTPBP1 WDR62

4.17e-06774881115302935
Pubmed

The Cumulative Effects of the MYH7-V878A and CACNA1C-A1594V Mutations in a Chinese Family with Hypertrophic Cardiomyopathy.

CACNA1C MYH7

6.33e-06288228866666
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NF1 IPO7 COPA UBR5 CPSF1 BAZ1B MCM5 CHD1 EXOC1 CHD7 XPC HSP90AB2P SNRNP200 RASAL2

7.42e-061353881429467282
Pubmed

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.

ANKRD11 CHD7 NSDHL

8.56e-061688310932191
Pubmed

A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.

IPO7 COPA UBR5 G3BP2

8.73e-065188426839216
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NRM CYB5B NF1 COPA TOR1A CPSF1 UBIAD1 PLXNB2 FKBP11 PLOD2 ALG6 WDR62 PCYOX1

1.01e-051201881335696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

NRM CYB5B IPO8 IPO7 BAZ1B CHD1 XPC ABCD1 UBIAD1 INTS3 PLXNB2 SNRNP200 NSDHL

1.03e-051203881329180619
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

NF1 IPO7 COPA UBR5 SYNE2 TOR1A CPSF1 BAZ1B MCM5 CHD1 PLXNB2 SNRNP200

1.05e-051024881224711643
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

KIF13B NF1 ASAP3 SLITRK3 NIBAN2 UBIAD1 SLC29A2 ITGB6 RASAL2

1.43e-0556988930639242
Pubmed

Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.

MYH3 MYH7

1.90e-0538821939265
Pubmed

Chromatin remodeler CHD1 promotes XPC-to-TFIIH handover of nucleosomal UV lesions in nucleotide excision repair.

CHD1 XPC

1.90e-05388229018037
Pubmed

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.

MYH3 MYH7

1.90e-0538821694848
Pubmed

Preferential utilization of Imp7/8 in nuclear import of Smads.

IPO8 IPO7

1.90e-05388218519565
Pubmed

Identification of three developmentally controlled isoforms of human myosin heavy chains.

MYH3 MYH7

1.90e-0538821691980
Pubmed

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.

SGK1 NDRG2

1.90e-05388215461589
Pubmed

An Alternative Splicing Program for Mouse Craniofacial Development.

SYNE2 EXOC1 PLOD2

2.01e-052188333013468
Pubmed

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.

IPO8 IPO7 COPA SNRNP200

3.45e-057288436376293
Pubmed

Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

AGBL5 AGBL1 AGTPBP1

3.46e-052588329593216
Pubmed

Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).

AGBL5 AGTPBP1

3.79e-05488223085998
Pubmed

A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling.

CACNA1C CAMK1

3.79e-05488235412911
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

NF1 IPO8 IPO7 COPA UBR5 TOR1A UBIAD1 SNRNP200 YARS1

4.39e-0565788936180527
Pubmed

A novel class of RanGTP binding proteins.

IPO8 IPO7

6.30e-0558829214382
Pubmed

Clinical exome sequencing in early-onset generalized dystonia and large-scale resequencing follow-up.

TOR1A ANO3

6.30e-05588227666935
Pubmed

Developmental regulation of myosin gene expression in mouse cardiac muscle.

MYH3 MYH7

6.30e-0558822277065
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

IPO7 COPA UBR5 ANKRD11 CPSF1 AGTPBP1

6.45e-0526988629511261
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

TMTC1 IPO8 COPA UBR5 MRPL37 CHD7 XPC

6.77e-0539688726687479
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

KIF13B PLBD1 NF1 PIK3R2 G3BP2 BAZ1B CHD7 ABCD1 PRAMEF2 PLXNB2 RASAL2 DOP1B

6.86e-051242881230973865
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

KIF13B COPA UBR5 G3BP2 MRPL37 BAZ1B MCM5 SNRNP200 NSDHL

7.46e-0570488929955894
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

MYH3 NF1 ACTR5 MCM5 CHD7 XPC SNRNP200

8.40e-0541088726949251
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

INTS10 IPO7 COPA MRPL37 EXOC1 SNRNP200 PCYOX1 NSDHL

8.93e-0556088835241646
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

MYH7 UBR5 SGK1 G3BP2 TMBIM4 TOR1A MCM5 CHD1 PLOD2 SNRNP200 YARS1 RASAL2

9.40e-051284881217353931
Pubmed

Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.

MYH3 MYH7

9.43e-05688228381556
Pubmed

Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.

MYH3 MYH7

9.43e-0568821728586
Pubmed

The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype.

AGBL1 AGTPBP1

9.43e-05688216952463
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE2 TOR1A

9.43e-05688218827015
Pubmed

Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.

MYH3 MYH7

9.43e-05688210588881
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

CYB5B UBR5 SYNE2 NIBAN2 ABCD1 UBIAD1 ITGB6 NSDHL

9.85e-0556888837774976
Pubmed

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.

IPO8 IPO7 UBR5 MCM5

1.02e-049588429490077
Pubmed

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

G3BP2 SYNE2 MCM5 PLOD2

1.15e-049888434943047
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

IPO7 SYNE2 BAZ1B CHD7 NSDHL

1.28e-0419188531177093
Pubmed

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

IPO8 IPO7

1.32e-04788211682607
Pubmed

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

MYH3 MYH7

1.32e-04788235210422
Pubmed

ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.

MYH3 MYH7

1.32e-04788229758057
Pubmed

Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.

CACNA1C MYH7

1.32e-0478829004034
Pubmed

Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.

MYH3 MYH7

1.32e-04788216819597
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

NF1 COPA CPSF1 MCM5 PLXNB2 SNRNP200

1.48e-0431388638270169
Pubmed

Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.

MYH3 MYH7 NEK10 CHD7 PLOD2

1.48e-0419788523686814
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

DPP7 NRM IPO7 COPA MCM5 PLXNB2 PLOD2 SNRNP200

1.66e-0461388822268729
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

CYB5B IPO8 COPA G3BP2 SYNE2 MCM5 EXOC1 NIBAN2 INTS3 PLXNB2 PCYOX1 NSDHL

1.69e-041367881232687490
Pubmed

Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.

MYH3 MYH7

1.75e-0488823864153
Pubmed

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

IPO8 IPO7

1.75e-04888227114554
Pubmed

Defining the membrane proteome of NK cells.

NRM CYB5B NF1 IPO7 COPA UBR5 MCM5 EXOC1 ABCD1 FKBP11 ALG6

1.76e-041168881119946888
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

NF1 UBR5 BAZ1B SNRNP200 WDR62

2.00e-0421088516565220
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

INTS10 IPO7 COPA G3BP2 MCM5 EXOC1 SNRNP200 YARS1 WDR62

2.12e-0480988932129710
Pubmed

Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval.

NF1 RNF135

2.25e-04988216138909
Pubmed

Muscle-specific gene expression during myogenesis in the mouse.

MYH3 MYH7

2.25e-0498827787235
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

IPO7 COPA BAZ1B CHD1 INTS3 SNRNP200

2.31e-0434088629478914
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

IPO7 COPA UBR5 ACTR5 G3BP2 SYNE2 MCM5 CHD1 HSP90AB2P INTS3 SNRNP200 YARS1

2.32e-041415881228515276
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CYB5B IPO8 IPO7 COPA UBR5 G3BP2 SYNE2 MCM5 EXOC1 HSP90AB2P PLOD2 SNRNP200

2.72e-041440881230833792
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

UBR5 SYNE2 CHD7 SNRNP200 DOP1B

2.74e-0422588512168954
Pubmed

The expression of myosin genes in developing skeletal muscle in the mouse embryo.

MYH3 MYH7

2.81e-04108822211821
Pubmed

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.

SGK1 CAMK1

2.81e-041088220433920
Pubmed

LZTR1 is a regulator of RAS ubiquitination and signaling.

NF1 EXOC1 NIBAN2 HSP90AB2P

3.12e-0412788430442766
Pubmed

FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.

UBR5 MRPL37 HSP90AB2P SNRNP200

3.21e-0412888428027390
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MYH7 COPA UBR5 INTS3 PLOD2 SNRNP200 YARS1 AGTPBP1 NSDHL

3.23e-0485788925609649
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

DNHD1 COPA PIK3R2 SYNE2 MCM5 PLOD2

3.27e-0436388625036637
Pubmed

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.

INTS10 INTS3

3.43e-041188223904267
Pubmed

Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.

ZSCAN20 YARS1

3.43e-041188216429158
Pubmed

The FgfrL1 receptor is required for development of slow muscle fibers.

MYH3 MYH7

3.43e-041188225172430
Pubmed

Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.

MYH3 MYH7

3.43e-041188216024798
Pubmed

Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.

INTS10 PHYHIP BAZ1B

3.54e-045488323505323
Pubmed

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

INTS10 MED25 INTS3

3.54e-045488316239144
Pubmed

Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.

SYNE2 TOR1A

4.11e-041288229868845
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

ACTR5 MED25 TOR1A BAZ1B CHD1 INTS3 SNRNP200

4.16e-0453388730554943
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

INTS10 COPA ACTR5 ANKRD11 CPSF1 BAZ1B CHD7 XPC INTS3 FKBP11 SNRNP200

4.21e-041294881130804502
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

CYB5B IPO7 COPA UBR5 SYNE2 TOR1A PLXNB2 PLOD2 YARS1 PCYOX1 NSDHL

4.30e-041297881133545068
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

MYH7 UBR5 MCM5 CHD1 HSP90AB2P CAMK1 SNRNP200

4.39e-0453888728524877
Pubmed

Global phosphoproteome of HT-29 human colon adenocarcinoma cells.

NF1 UBR5 NIBAN2

4.59e-045988316083285
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

UBR5 ACTR5 MRPL37 INTS3 PLOD2 SNRNP200

4.78e-0439088617643375
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

IPO8 UBR5 G3BP2 EFR3B NIBAN2 UBIAD1 PLXNB2 RASAL2

4.82e-0471988835337019
Pubmed

RNF135 mutations are not present in patients with Sotos syndrome-like features.

NF1 RNF135

4.85e-041388219291764
Pubmed

Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.

MYH3 MYH7

4.85e-04138828404542
Pubmed

Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse.

NF1 RNF135

4.85e-041388212696059
Pubmed

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.

INTS10 INTS3

5.65e-041488232697989
Pubmed

Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice.

MYH7 MED25

5.65e-041488238327785
Pubmed

Functional domains of the FgfrL1 receptor.

MYH3 MYH7

5.65e-041488231923383
InteractionBTNL9 interactions

FOCAD CYB5B IPO8 IPO7 CSNK1G1 CAMK1 AGBL5 INTS3

4.10e-07156888int:BTNL9
InteractionNR3C1 interactions

CYB5B NF1 IPO7 DYNC2H1 G3BP2 MRPL37 SYNE2 MED25 MCM5 CHD7 XPC INTS3 RASAL2 PCYOX1 NSDHL

1.91e-059748815int:NR3C1
InteractionTMEM260 interactions

TMEM260 MYH3 MYH7

2.23e-0513883int:TMEM260
InteractionNRAS interactions

KIF13B CYB5B NF1 EFR3B SLITRK3 EXOC1 NIBAN2 HSP90AB2P UBIAD1 ITGB6 RASAL2 NSDHL

5.07e-056998812int:NRAS
InteractionBIRC3 interactions

DNHD1 NF1 IPO8 IPO7 COPA DYNC2H1 G3BP2 MRPL37 CPSF1 BAZ1B MCM5 CHD1 SNRNP200 YARS1 RASAL2 PCYOX1 NSDHL

5.59e-0513348817int:BIRC3
InteractionTESK2 interactions

KIF13B NF1 UBR5 HSP90AB2P RASAL2

6.65e-0597885int:TESK2
InteractionHRAS interactions

NF1 SGK1 ASAP3 ANKRD11 EXOC1 NIBAN2 HSP90AB2P UBIAD1 HDHD2 SLC29A2 ITGB6 RASAL2

7.20e-057258812int:HRAS
InteractionSUPT5H interactions

INTS10 UBR5 SYNE2 PHYHIP BAZ1B CHD7 INTS3 PLOD2 SNRNP200

7.29e-05408889int:SUPT5H
GeneFamilyIntegrator complex

INTS10 INTS3

9.64e-04155621366
GeneFamilyMyosin heavy chains

MYH3 MYH7

9.64e-04155621098
GeneFamilyArmadillo repeat containing|Importins

IPO8 IPO7

1.40e-0318562596
ComputationalNeighborhood of EI24

IPO7 G3BP2 BAZ1B SNRNP200 YARS1 NSDHL

1.04e-04143576MORF_EI24
DrugBenfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A

JAK3 KIF13B IPO8 COPA ACTR5 CYP26A1 MED25

1.07e-051958872621_DN
DrugNaltrexone hydrochloride dihydrate [16676-29-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A

JAK3 SGK1 PIK3R2 BAZ1B ABCD1 INPP5J RASAL2

1.15e-051978876241_UP
DrugS(-)-terguride hydrogen maleate [37686-85-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A

KIF13B NF1 IPO8 CYP26A1 BAZ1B UBIAD1 WDR62

1.18e-051988876473_DN
Drugcopper(II) sulfate pentahydrate; Down 200; 100uM; PC3; HG-U133A

IPO8 COPA ACTR5 EFR3B PLXNB2 NDRG2 FKBP11

1.18e-05198887459_DN
DrugKetoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A

JAK3 KIF13B NF1 IPO8 ACTR5 SGK1 MED25

1.18e-051988872640_DN
DrugU-62066 [87151-85-7]; Down 200; 1uM; MCF7; HT_HG-U133A

KIF13B NF1 ASAP3 CAMK1 NDRG2 ITGB6 WDR62

1.18e-051988873901_DN
DrugApramycin [37321-09-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A

NF1 IPO8 COPA CSNK1G1 CYP26A1 ABCD1 RASAL2

1.26e-052008874959_DN
DiseaseNF1 Microdeletion Syndrome

NF1 RNF135

8.20e-062852C3150928
DiseaseT-cell non-Hodgkin lymphoma (is_implicated_in)

TMEM260 JAK3

4.90e-054852DOID:0081312 (is_implicated_in)
Diseasejuvenile myelomonocytic leukemia (is_implicated_in)

JAK3 NF1

1.71e-047852DOID:0050458 (is_implicated_in)
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

MYH7 SYNE2

1.71e-047852C0751337
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:0110454 (implicated_via_orthology)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:0111269 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:0080719 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:0111602 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:0080326 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH3 MYH7

3.64e-0410852DOID:0111596 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH3 MYH7

5.31e-0412852DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH3 MYH7

5.31e-0412852DOID:2106 (implicated_via_orthology)
Diseasetea consumption measurement

CYB5B CYP26A1 PHYHIP ALG6

5.37e-04129854EFO_0010091
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH3 MYH7

6.27e-0413852DOID:397 (implicated_via_orthology)
Diseasecolon cancer (is_marker_for)

NF1 UBR5 PIK3R2

6.68e-0459853DOID:219 (is_marker_for)
Diseaserostral middle frontal gyrus volume measurement

AGBL1 ITGB6

7.30e-0414852EFO_0010328
DiseaseMMR-related febrile seizures

AGBL1 ANO3

8.40e-0415852EFO_0006519
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH3 MYH7

8.40e-0415852DOID:0050646 (implicated_via_orthology)
Diseasenon-high density lipoprotein cholesterol measurement

INTS10 KIF13B MYO1H CYP26A1 SYNE2 RNF135 ASAP3 CHD7

1.05e-03713858EFO_0005689
DiseaseDystonia, Limb

TOR1A ANO3

1.08e-0317852C0751093
DiseaseDystonia, Diurnal

TOR1A ANO3

1.08e-0317852C0393610
Diseaseprotein C measurement

CYP27C1 BAZ1B

1.08e-0317852EFO_0004633
DiseaseDystonia, Paroxysmal

TOR1A ANO3

1.22e-0318852C0393588
DiseasePhenyllactate (PLA) measurement

ST6GAL2 IPO8

1.36e-0319852EFO_0021662
DiseaseOmenn Syndrome

JAK3 CHD7

1.36e-0319852C2700553
DiseaseJuvenile Myelomonocytic Leukemia

JAK3 NF1

1.36e-0319852C0349639
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

INTS10 MYO1H CYP26A1 SYNE2

1.37e-03166854EFO_0004530, EFO_0004611
Diseaseinterleukin 10 measurement

IPO7 DYNC2H1 MRPL37

1.50e-0378853EFO_0004750
Diseasefatty acid measurement

INTS10 MYO1H CYP26A1 ASAP3 BAZ1B PLOD2

1.65e-03436856EFO_0005110
DiseaseImmunologic Deficiency Syndromes

CACNA1C CHD7

1.99e-0323852C0021051
Diseaseunipolar depression, schizophrenia

CACNA1C ACTR5

2.36e-0325852EFO_0003761, MONDO_0005090
Diseasephospholipid measurement, high density lipoprotein cholesterol measurement

INTS10 MYO1H CYP26A1 ASAP3 RASAL2

2.38e-03321855EFO_0004612, EFO_0004639
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

INTS10 MYO1H CYP26A1 SYNE2

2.70e-03200854EFO_0004611, EFO_0020945
Diseaseretinitis pigmentosa (implicated_via_orthology)

SNRNP200 AGTPBP1

2.75e-0327852DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
VLHPAIYGAKAVLLY

AGBL5

321

Q8NDL9
LHYAALYNQPDCLKL

ASAP3

626

Q8TDY4
YLIPKGTQLALCHYA

CYP27C1

431

Q4G0S4
HYKVVKLLLRYGGNP

ANKRD11

246

Q6UB99
LLYPGLILIDYGHFQ

ALG6

151

Q9Y672
LPPAALHLIAYYKEN

BAZ1B

471

Q9UIG0
YLQRLLQLKYPGHLA

ACTR5

221

Q9H9F9
LGELHHLYAPLYQEA

DNHD1

1756

Q96M86
LYEKYQLTSQHGPLL

ADCY7

21

P51828
PVGGNFEILLHYYLL

BBS10

601

Q8TAM1
PTIYHAKGLLQYLAA

AGTPBP1

991

Q9UPW5
YGHPATLLKDYILQA

LINC02877

56

P0CE67
FLYEIYLKGIHGPFL

CHD7

1006

Q9P2D1
YGYASLHKELEPFLL

CHD1

681

O14646
AHLQPTIYHAKGLLY

AGBL1

871

Q96MI9
YKHQPLDLIRLYFGE

ANO3

376

Q9BYT9
LLSELYQKQPKIGYH

INTS3

676

Q68E01
LAYALNYLEDKGLPH

JAK3

631

P52333
HDVRLPANLLYKYLN

INTS10

186

Q9NVR2
LHEPAVLYNLKDRYG

MYH7

96

P12883
LVPHNYGLVLYENKA

NIBAN2

91

Q96TA1
LLALAAYGAHKVYPL

ABCD1

21

P33897
LPCIYYLLEKGADLN

ANKRD53

191

Q8N9V6
GLLYLIHYEDALHKP

OR52N4

46

Q8NGI2
ALILNRHKYPLNLYL

TMBIM4

86

Q9HC24
FHKVAGQLLPLAYNL

nan

306

A8MVJ9
DYLYKQPAEHLQLLE

MCM5

86

P33992
KHSQFLGYPITLYLE

HSP90AB2P

126

Q58FF8
DGAPLIAIHKARYYK

HDHD2

136

Q9H0R4
LAIPNYHYRDDGLKI

ALOXE3

501

Q9BYJ1
VEALFKHILLYLQPY

DOP1B

1221

Q9Y3R5
APQLHLEYRFYKQLG

CSNK1G1

81

Q9HCP0
LQFLHGYYEPTLLIL

CPSF1

206

Q10570
PSIILHDRLYYLNGI

PCYOX1

446

Q9UHG3
LPLHLYVKSYGKNID

PLXNB2

736

O15031
APLKYIGNYAILDHL

NEK10

511

Q6ZWH5
AIAALYYNPHLLLNT

IPO7

786

O95373
HLYENYAKLIPGATV

ITGB6

336

P18564
KHYEALYGLLALISI

EFR3B

541

Q9Y2G0
YLKLVGQQYLHDALG

RASAL2

381

Q9UJF2
HNLYPLLFKASYLLE

LRRC14B

31

A6NHZ5
YFEGLRKHYLLPAIE

MED25

31

Q71SY5
RKHYLLPAIEYFNGG

MED25

36

Q71SY5
YYHVLGLGEPLALKS

NRM

171

Q8IXM6
PYPHTLYLLDKANLR

MRPL37

286

Q9BZE1
PLLVQKLGLDYSYDL

PLBD1

416

Q6P4A8
ADKYPVVHIGKRYLN

PLOD2

151

O00469
GIVHRDLKPENLLYY

CAMK1

136

Q14012
EPYNLYGSLKELVLH

PIK3R2

681

O00459
HLDHYYQEELPALLK

FCHSD1

221

Q86WN1
IYGAYLEPVLHKNLK

DYNC2H1

2441

Q8NCM8
PALLGLIGYHLYRKA

FKBP11

166

Q9NYL4
LKVIAYGLLFHPNAY

CACNA1C

176

Q13936
HPYYTIKDALGLLLF

MT-CYB

221

P00156
IAYLQKKGYPEVALH

COPA

626

P53621
YYIEVLPKHLALGDQ

FNDC11

76

Q9BVV2
TLLNKAPEYLHRFYG

G3BP2

21

Q9UN86
LKQYYIGDIHPSDLK

CYB5B

91

O43169
SLITYLGLYPHVLQK

CYP26A1

311

O43174
YVIYSLGQPLEKLNH

EXOC1

766

Q9NV70
TTAYYPLKLHFGGLL

PRDM13

476

Q9H4Q3
LLVFAEHRYYGKSLP

DPP7

101

Q9UHL4
YNDILYTLPKLGVHK

FOCAD

506

Q5VW36
AIAALYYNPDLLLHT

IPO8

786

O15397
ILLKFLNHNGYLDPK

MROH5

611

Q6ZUA9
DPALNELLVYYLKEH

KIF13B

456

Q9NQT8
LYGLHPGNYLIIKQV

RNF135

416

Q8IUD6
EKYLPALGYSKRVHL

YARS1

196

P54577
LSLPHLKFARYYLAN

SLC29A2

211

Q14542
GERLHLPYALLQEVY

SYNE2

4696

Q8WXH0
KRPAILTYHDVGLNY

NDRG2

61

Q9UN36
GYLHSLNIVYRDLKP

SGK1

211

O00141
KNYFLYLPVAGVLEH

SLITRK3

536

O94933
ACTLGAYHPLLYEKL

ST6GAL2

476

Q96JF0
AYHPLLYEKLLVQRL

ST6GAL2

481

Q96JF0
HLNEPAVLYNLKDRY

MYH3

96

P11055
RILTGLNYEAPKYHI

NSDHL

281

Q15738
EASLHQPLYYLLSLL

OR56A3

56

Q8NH54
AYHYAILVLAPKGSL

PHYHIP

231

Q92561
FPSLGYLKHLNLSYV

PRAMEF2

316

O60811
QLIDHYGLDDKLLHY

SFR1

221

Q86XK3
GVILLLFAKYYHLPF

INPP5J

506

Q15735
HAGLIDAIKPFLDYY

TOR1A

176

O14656
KLIDHQGLYLAEKPY

ZSCAN20

696

P17040
HKAEILSPLGALYYN

TMTC1

681

Q8IUR5
DLLIYHVLLTLKPYY

NF1

1621

P21359
YLSPLKLEHLALIYF

UBIAD1

151

Q9Y5Z9
HYLANLPKPHYLGVD

WDR62

326

O43379
NLELKDLLPYGFAIH

SNRNP200

771

O75643
TAIGLYKNHPLYALK

XPC

636

Q01831
LIPKYNHLVYSQIPA

UBR5

1801

O95071
KLSLYFSAGLLPYVH

TMEM260

221

Q9NX78
YILNLRYHLPKTVLD

MYO1H

786

Q8N1T3