Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2D KMT2B

5.17e-078433GO:0140945
GeneOntologyMolecularFunctionhistone modifying activity

KDM2B KMT2C KMT2D SUZ12 KMT2B BRD1 HR

5.40e-07229437GO:0140993
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2D KMT2B

1.10e-0610433GO:0140999
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP2 LRP1B SORL1

5.11e-0616433GO:0005041
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2D KMT2B

1.03e-0520433GO:0042800
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP2 LRP1B SORL1

1.20e-0521433GO:0030228
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2C KMT2D SUZ12 KMT2B

1.63e-0571434GO:0042054
GeneOntologyMolecularFunctionprotein methyltransferase activity

KMT2C KMT2D SUZ12 KMT2B

7.06e-05103434GO:0008276
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2C KMT2D KMT2B

1.16e-0444433GO:0140938
GeneOntologyMolecularFunctionunmethylated CpG binding

KDM2B KMT2B

2.02e-0410432GO:0045322
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNC1 PLXNA2

2.95e-0412432GO:0017154
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2C KMT2D KMT2B

4.23e-0468433GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2C KMT2D KMT2B

4.41e-0469433GO:0016278
GeneOntologyMolecularFunctioncargo receptor activity

LRP2 LRP1B SORL1

8.12e-0485433GO:0038024
GeneOntologyMolecularFunctionmethyltransferase activity

KMT2C KMT2D SUZ12 KMT2B

1.12e-03213434GO:0008168
GeneOntologyMolecularFunctionacyltransferase activity

KMT2C G2E3 BRD1 ZDHHC17 RNF31 ZDHHC23 ZZEF1

1.23e-03775437GO:0016746
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

KMT2C KMT2D SUZ12 KMT2B

1.35e-03224434GO:0016741
GeneOntologyMolecularFunctionprotein-cysteine S-palmitoyltransferase activity

ZDHHC17 ZDHHC23

1.42e-0326432GO:0019706
GeneOntologyMolecularFunctionprotein-cysteine S-acyltransferase activity

ZDHHC17 ZDHHC23

1.42e-0326432GO:0019707
GeneOntologyMolecularFunctionhistone reader activity

BRD1 ZZEF1

1.42e-0326432GO:0140566
GeneOntologyMolecularFunctionN-methyltransferase activity

KMT2C KMT2D KMT2B

1.50e-03105433GO:0008170
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM2B HR

1.65e-0328432GO:0141052
GeneOntologyMolecularFunctionS-acyltransferase activity

ZDHHC17 ZDHHC23

1.90e-0330432GO:0016417
GeneOntologyMolecularFunctionhistone demethylase activity

KDM2B HR

2.02e-0331432GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM2B HR

2.16e-0332432GO:0140457
GeneOntologyMolecularFunctionpalmitoyltransferase activity

ZDHHC17 ZDHHC23

2.88e-0337432GO:0016409
GeneOntologyMolecularFunctionchromatin-protein adaptor activity

BRD1 ZZEF1

3.52e-0341432GO:0140463
GeneOntologyMolecularFunctiondemethylase activity

KDM2B HR

4.05e-0344432GO:0032451
GeneOntologyMolecularFunctioncalcium ion binding

LRP2 NOTCH2NLB MEGF8 ZZEF1 LRP1B NOTCH2

5.10e-03749436GO:0005509
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

KMT2C KMT2D KMT2B

6.02e-03172433GO:0008757
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

LRP2 PXN SPRY1 MEGF8 NOTCH2 SPRED3 SORL1

2.91e-05445427GO:0141091
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

LRP2 PXN SPRY1 MEGF8 NOTCH2 SPRED3 SORL1

4.84e-05482427GO:0007178
GeneOntologyBiologicalProcessnegative regulation of lens fiber cell differentiation

SPRY1 SPRED3

6.04e-056422GO:1902747
GeneOntologyBiologicalProcessregulation of neurogenesis

LRP2 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1 SORL1

7.34e-05515427GO:0050767
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

LRP2 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

7.63e-05354426GO:0050769
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

MEGF8 PLXNC1 PLXNA2 AMIGO1

8.42e-05114424GO:0050772
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

LRP2 CFAP418 ZDHHC17 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

1.14e-04748428GO:0048667
GeneOntologyBiologicalProcessaxonogenesis

LRP2 ZDHHC17 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

1.32e-04566427GO:0007409
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

LRP2 SPRY1 ZDHHC17 NOTCH2 SPRED3 SORL1

1.75e-04412426GO:0090287
GeneOntologyBiologicalProcessregulation of lens fiber cell differentiation

SPRY1 SPRED3

1.80e-0410422GO:1902746
GeneOntologyBiologicalProcesspositive regulation of nervous system development

LRP2 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

1.89e-04418426GO:0051962
GeneOntologyBiologicalProcessepithelial tube morphogenesis

LRP2 PXN KDM2B SPRY1 MEGF8 NOTCH2

1.96e-04421426GO:0060562
GeneOntologyBiologicalProcessregulation of nervous system development

LRP2 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1 SORL1

2.43e-04625427GO:0051960
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

LRP2 PXN SPRY1 ZDHHC17 MEGF8 NOTCH2 SPRED3 SORL1

2.73e-04850428GO:0071363
GeneOntologyBiologicalProcessaxon development

LRP2 ZDHHC17 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

2.86e-04642427GO:0061564
GeneOntologyBiologicalProcessresponse to growth factor

LRP2 PXN SPRY1 ZDHHC17 MEGF8 NOTCH2 SPRED3 SORL1

3.53e-04883428GO:0070848
GeneOntologyBiologicalProcessregionalization

LRP2 KDM2B SPRY1 MEGF8 PLXNA2 NOTCH2

3.88e-04478426GO:0003002
GeneOntologyBiologicalProcesschromatin organization

KDM2B KMT2C KMT2D SUZ12 KMT2B BRD1 ZZEF1 HR

3.89e-04896428GO:0006325
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

LRP2 CCN4 GDPD2 BRD1 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

4.00e-041141429GO:0045597
GeneOntologyBiologicalProcesschordate embryonic development

LRP2 KDM2B G2E3 KMT2D MEGF8 LRP1B PLXNA2 NOTCH2

4.19e-04906428GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

LRP2 KDM2B G2E3 KMT2D MEGF8 LRP1B PLXNA2 NOTCH2

4.96e-04929428GO:0009792
GeneOntologyBiologicalProcessregulation of neurotrophin TRK receptor signaling pathway

SPRY1 ZDHHC17

5.40e-0417422GO:0051386
GeneOntologyBiologicalProcesscell morphogenesis

LRP2 PXN CFAP418 ZDHHC17 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

5.57e-041194429GO:0000902
GeneOntologyBiologicalProcessregulation of axonogenesis

MEGF8 PLXNC1 PLXNA2 AMIGO1

6.18e-04192424GO:0050770
GeneOntologyBiologicalProcesspattern specification process

LRP2 KDM2B SPRY1 MEGF8 PLXNA2 NOTCH2

6.43e-04526426GO:0007389
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

LRP2 SPRY1 NOTCH2 SPRED3 SORL1

6.68e-04347425GO:0090092
GeneOntologyBiologicalProcesschromatin remodeling

KDM2B KMT2C KMT2D SUZ12 KMT2B BRD1 HR

6.76e-04741427GO:0006338
GeneOntologyBiologicalProcessBMP signaling pathway

LRP2 MEGF8 NOTCH2 SORL1

6.80e-04197424GO:0030509
GeneOntologyBiologicalProcessprotein-DNA complex organization

KDM2B KMT2C KMT2D SUZ12 KMT2B BRD1 ZZEF1 HR

8.00e-04999428GO:0071824
GeneOntologyBiologicalProcessresponse to BMP

LRP2 MEGF8 NOTCH2 SORL1

9.42e-04215424GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

LRP2 MEGF8 NOTCH2 SORL1

9.42e-04215424GO:0071773
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

LRP2 SPRY1 SPRED3 SORL1

9.92e-04218424GO:0090101
GeneOntologyBiologicalProcessneuron projection morphogenesis

LRP2 ZDHHC17 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

1.08e-03802427GO:0048812
GeneOntologyBiologicalProcesspeptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine

ZDHHC17 ZDHHC23

1.09e-0324422GO:0018231
GeneOntologyBiologicalProcesspeptidyl-L-cysteine S-palmitoylation

ZDHHC17 ZDHHC23

1.09e-0324422GO:0018230
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

LRP2 ZDHHC17 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

1.21e-03819427GO:0120039
GeneOntologyBiologicalProcessneural precursor cell proliferation

LRP2 KDM2B ZZEF1 NOTCH2

1.27e-03233424GO:0061351
GeneOntologyBiologicalProcesscell projection morphogenesis

LRP2 ZDHHC17 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

1.28e-03826427GO:0048858
GeneOntologyBiologicalProcesspositive regulation of cell development

LRP2 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1

1.43e-03614426GO:0010720
GeneOntologyBiologicalProcessregulation of cell development

LRP2 BRD1 MEGF8 PLXNC1 PLXNA2 NOTCH2 AMIGO1 SORL1

1.45e-031095428GO:0060284
GeneOntologyBiologicalProcesslipoprotein transport

LRP2 ZDHHC17

1.48e-0328422GO:0042953
GeneOntologyBiologicalProcessneuron projection fasciculation

MEGF8 AMIGO1

1.48e-0328422GO:0106030
GeneOntologyBiologicalProcessaxonal fasciculation

MEGF8 AMIGO1

1.48e-0328422GO:0007413
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

LRP2 PXN KDM2B SPRY1 MEGF8 NOTCH2

1.49e-03619426GO:0002009
GeneOntologyBiologicalProcesslipoprotein localization

LRP2 ZDHHC17

1.59e-0329422GO:0044872
GeneOntologyBiologicalProcesscamera-type eye development

KDM2B SPRY1 KMT2C NOTCH2 SPRED3

1.66e-03426425GO:0043010
GeneOntologyBiologicalProcessprotein palmitoylation

ZDHHC17 ZDHHC23

2.05e-0333422GO:0018345
GeneOntologyBiologicalProcessneurotrophin TRK receptor signaling pathway

SPRY1 ZDHHC17

2.18e-0334422GO:0048011
GeneOntologyBiologicalProcesspharyngeal system development

MEGF8 PLXNA2

2.18e-0334422GO:0060037
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2C KMT2D SUZ12 KMT2B

1.54e-0575424GO:0035097
GeneOntologyCellularComponentmethyltransferase complex

KMT2C KMT2D SUZ12 KMT2B

6.48e-05108424GO:0034708
GeneOntologyCellularComponentreceptor complex

LRP2 GPR20 RNF31 LRP1B PLXNC1 PLXNA2 NOTCH2

1.43e-04581427GO:0043235
GeneOntologyCellularComponentMLL3/4 complex

KMT2C KMT2D

2.57e-0412422GO:0044666
GeneOntologyCellularComponentsemaphorin receptor complex

PLXNC1 PLXNA2

3.03e-0413422GO:0002116
DomainEPHD

KMT2C G2E3 KMT2D KMT2B BRD1

1.01e-0922415PS51805
DomainPHD

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1

3.88e-0889416SM00249
DomainZnf_PHD

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1

4.44e-0891416IPR001965
DomainZF_PHD_2

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1

5.75e-0895416PS50016
DomainZF_PHD_1

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1

6.12e-0896416PS01359
DomainFYrich_C

KMT2C KMT2D KMT2B

9.79e-085413IPR003889
DomainFYrich_N

KMT2C KMT2D KMT2B

9.79e-085413IPR003888
DomainFYRC

KMT2C KMT2D KMT2B

9.79e-085413SM00542
DomainFYRN

KMT2C KMT2D KMT2B

9.79e-085413SM00541
DomainFYRN

KMT2C KMT2D KMT2B

9.79e-085413PF05964
DomainFYRC

KMT2C KMT2D KMT2B

9.79e-085413PF05965
DomainFYRC

KMT2C KMT2D KMT2B

9.79e-085413PS51543
DomainFYRN

KMT2C KMT2D KMT2B

9.79e-085413PS51542
DomainZnf_FYVE_PHD

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1

7.69e-07147416IPR011011
DomainZnf_PHD-finger

KDM2B KMT2C KMT2D KMT2B BRD1

7.92e-0779415IPR019787
DomainLdl_recept_b

LRP2 LRP1B SORL1

3.51e-0614413PF00058
DomainLDLRB

LRP2 LRP1B SORL1

3.51e-0614413PS51120
DomainLY

LRP2 LRP1B SORL1

4.39e-0615413SM00135
DomainLDLR_classB_rpt

LRP2 LRP1B SORL1

4.39e-0615413IPR000033
DomainPost-SET_dom

KMT2C KMT2D KMT2B

5.39e-0616413IPR003616
DomainPostSET

KMT2C KMT2D KMT2B

5.39e-0616413SM00508
DomainPOST_SET

KMT2C KMT2D KMT2B

5.39e-0616413PS50868
DomainPHD

KMT2C KMT2D KMT2B BRD1

2.17e-0575414PF00628
DomainDHHC

KMT2C ZDHHC17 ZDHHC23

2.18e-0525413PS50216
DomainZnf_DHHC_palmitoyltrfase

KMT2C ZDHHC17 ZDHHC23

2.18e-0525413IPR001594
DomainGrowth_fac_rcpt_

LRP2 CCN4 MEGF8 LRP1B NOTCH2

2.24e-05156415IPR009030
DomainEGF_CA

LRP2 MEGF8 LRP1B NOTCH2

3.73e-0586414PF07645
DomainPlexin_repeat

MEGF8 PLXNC1 PLXNA2

4.66e-0532413IPR002165
DomainPSI

MEGF8 PLXNC1 PLXNA2

4.66e-0532413PF01437
Domain-

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1 CGRRF1

4.91e-054494173.30.40.10
DomainZnf_RING/FYVE/PHD

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1 CGRRF1

5.64e-05459417IPR013083
DomainEGF_Ca-bd_CS

LRP2 MEGF8 LRP1B NOTCH2

5.97e-0597414IPR018097
DomainEGF_CA

LRP2 MEGF8 LRP1B NOTCH2

6.47e-0599414PS01187
DomainASX_HYDROXYL

LRP2 MEGF8 LRP1B NOTCH2

6.73e-05100414PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP2 MEGF8 LRP1B NOTCH2

8.44e-05106414IPR000152
Domain-

LRP2 LRP1B SORL1

8.49e-05394132.120.10.30
DomainLDLR_class-A_CS

LRP2 LRP1B SORL1

9.17e-0540413IPR023415
DomainSPR

SPRY1 SPRED3

9.81e-057412PS51227
DomainSprouty

SPRY1 SPRED3

9.81e-057412IPR007875
DomainSprouty

SPRY1 SPRED3

9.81e-057412PF05210
DomainSET

KMT2C KMT2D KMT2B

9.88e-0541413PF00856
DomainPSI

MEGF8 PLXNC1 PLXNA2

1.22e-0444413IPR016201
DomainLdl_recept_a

LRP2 LRP1B SORL1

1.31e-0445413PF00057
DomainPSI

MEGF8 PLXNC1 PLXNA2

1.40e-0446413SM00423
DomainSET

KMT2C KMT2D KMT2B

1.40e-0446413SM00317
Domain-

LRP2 LRP1B SORL1

1.40e-04464134.10.400.10
Domain6-blade_b-propeller_TolB-like

LRP2 LRP1B SORL1

1.40e-0446413IPR011042
DomainEGF_CA

LRP2 MEGF8 LRP1B NOTCH2

1.46e-04122414SM00179
DomainEGF-like_Ca-bd_dom

LRP2 MEGF8 LRP1B NOTCH2

1.55e-04124414IPR001881
DomainEGF_3

LRP2 MEGF8 LRP1B NOTCH2 SORL1

1.57e-04235415PS50026
DomainEGF

LRP2 MEGF8 LRP1B NOTCH2 SORL1

1.57e-04235415SM00181
DomainLDLRA_1

LRP2 LRP1B SORL1

1.59e-0448413PS01209
DomainPlexin_cytopl

PLXNC1 PLXNA2

1.68e-049412PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNC1 PLXNA2

1.68e-049412IPR013548
DomainPlexin

PLXNC1 PLXNA2

1.68e-049412IPR031148
DomainLDrepeatLR_classA_rpt

LRP2 LRP1B SORL1

1.69e-0449413IPR002172
DomainLDLa

LRP2 LRP1B SORL1

1.69e-0449413SM00192
DomainLDLRA_2

LRP2 LRP1B SORL1

1.69e-0449413PS50068
DomainSET_dom

KMT2C KMT2D KMT2B

1.79e-0450413IPR001214
DomainSET

KMT2C KMT2D KMT2B

1.79e-0450413PS50280
DomainEGF-like_dom

LRP2 MEGF8 LRP1B NOTCH2 SORL1

2.05e-04249415IPR000742
DomainEGF-like_CS

LRP2 MEGF8 LRP1B NOTCH2 SORL1

2.55e-04261415IPR013032
Domainzf-CXXC

KDM2B KMT2B

2.55e-0411412PF02008
DomainZnf_CXXC

KDM2B KMT2B

2.55e-0411412IPR002857
DomainZF_CXXC

KDM2B KMT2B

2.55e-0411412PS51058
DomainEGF_2

LRP2 MEGF8 LRP1B NOTCH2 SORL1

2.73e-04265415PS01186
DomainLIM

PXN CRIP3 CRIP2

4.65e-0469413PF00412
Domain-

PXN CRIP3 CRIP2

4.85e-04704132.10.110.10
DomainLIM_DOMAIN_2

PXN CRIP3 CRIP2

5.06e-0471413PS50023
DomainZnf_LIM

PXN CRIP3 CRIP2

5.06e-0471413IPR001781
DomainLIM_DOMAIN_1

PXN CRIP3 CRIP2

5.06e-0471413PS00478
DomainLIM

PXN CRIP3 CRIP2

5.06e-0471413SM00132
DomainRING

KMT2C G2E3 KMT2D RNF31 CGRRF1

5.20e-04305415SM00184
DomainZnf_RING

KMT2C G2E3 KMT2D RNF31 CGRRF1

7.03e-04326415IPR001841
Domainzf-DHHC

ZDHHC17 ZDHHC23

1.16e-0323412PF01529
DomainJmjC

KDM2B HR

1.26e-0324412PF02373
DomaincEGF

LRP2 LRP1B

1.48e-0326412IPR026823
DomaincEGF

LRP2 LRP1B

1.48e-0326412PF12662
DomainIPT

PLXNC1 PLXNA2

1.59e-0327412SM00429
DomainAT_hook

KMT2C KMT2B

1.59e-0327412SM00384
DomainAT_hook_DNA-bd_motif

KMT2C KMT2B

1.59e-0327412IPR017956
DomainTIG

PLXNC1 PLXNA2

2.10e-0331412PF01833
DomainSEMA

PLXNC1 PLXNA2

2.10e-0331412PS51004
DomainSema

PLXNC1 PLXNA2

2.10e-0331412SM00630
DomainSemap_dom

PLXNC1 PLXNA2

2.10e-0331412IPR001627
DomainSema

PLXNC1 PLXNA2

2.10e-0331412PF01403
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

KMT2C KMT2D SUZ12 KMT2B

8.97e-0670274M27231
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM2B KMT2C KMT2D SUZ12 KMT2B BRD1

1.03e-05272276M29619
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM2B KMT2D SUZ12 KMT2B BRD1

1.80e-05175275MM14941
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2C KMT2D KMT2B

6.84e-0542273M48018
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

KMT2D SUZ12 KMT2B

9.00e-0546273MM14933
PathwayWP_HISTONE_MODIFICATIONS

KMT2C KMT2D KMT2B

2.53e-0465273M39374
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

PLXNC1 PLXNA2

5.92e-0419272M10959
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2C KMT2D KMT2B

7.95e-0496273M27792
PathwayKEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119

KDM2B SUZ12

7.97e-0422272M47924
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

KMT2C KMT2D SUZ12 KMT2B

1.30e-03254274M27131
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

KMT2C KMT2D SUZ12

1.59e-03122273M29689
PathwayWP_FBXL10_ENHANCEMENT_OF_MAPERK_SIGNALING_IN_DIFFUSE_LARGE_BCELL_LYMPHOMA

KDM2B SUZ12

1.80e-0333272M39800
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

KMT2D SUZ12 KMT2B

2.17e-03136273MM14848
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2C KMT2D KMT2B

7.55e-09444319221051
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2C KMT2D KMT2B

7.55e-09444323129768
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM2B KMT2C KMT2D KMT2B

1.31e-082144427626377
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C KMT2D KMT2B

3.77e-08644317021013
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2C KMT2D KMT2B

6.59e-08744330604749
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C KMT2D KMT2B

6.59e-08744319556342
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2C KMT2D KMT2B

1.05e-07844323130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2C KMT2D KMT2B

1.05e-07844322266653
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2C KMT2D KMT2B

1.58e-07944322665483
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2C KMT2D KMT2B

4.12e-071244327563068
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM2B KMT2C KMT2B HR

4.53e-074944434368113
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2C KMT2D KMT2B

5.36e-071344321502505
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM2B KMT2C KMT2D KMT2B

8.38e-075744418022353
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

KMT2C KMT2D KMT2B

1.05e-061644324368734
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

KMT2C KMT2D KMT2B

1.27e-061744326180087
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

KMT2C KMT2D KMT2B

1.52e-061844317500065
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

1.56e-06244228483418
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

1.56e-06244236869380
Pubmed

Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.

KMT2D KMT2B

1.56e-06244235506254
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

1.56e-06244228967912
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

1.56e-06244234156443
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

1.56e-06244225346535
Pubmed

Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).

KMT2D KMT2B

1.56e-06244235640156
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

1.56e-06244231924266
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

1.56e-06244227280393
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

1.56e-06244236601880
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

KMT2C KMT2D KMT2B

2.12e-062044319047629
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2C KMT2D KMT2B

2.86e-062244326886794
Pubmed

Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.

KMT2C KMT2D

4.69e-06344222183980
Pubmed

Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors.

KDM2B SUZ12

4.69e-06344228124441
Pubmed

Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.

KMT2D KMT2B

4.69e-06344232544095
Pubmed

Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.

KMT2D NOTCH2

4.69e-06344227566587
Pubmed

The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.

KMT2D KMT2B

4.69e-06344223358417
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2C KMT2D

4.69e-06344223932714
Pubmed

HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.

KMT2C KMT2D

4.69e-06344221683083
Pubmed

Rebalancing gene haploinsufficiency in vivo by targeting chromatin.

PXN KMT2C KMT2B

6.05e-062844327256596
Pubmed

Identification and characterization of a novel human PP1 phosphatase complex.

KMT2C KMT2D KMT2B

8.28e-063144320516061
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PXN KMT2C KMT2D KMT2B MEGF8 ZZEF1 IL17RE NOTCH2 HR

8.32e-06110544935748872
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

LRP2 GPR20 LRP1B NOTCH2

8.32e-0610144423382219
Pubmed

Cancer gene mutation frequencies for the U.S. population.

KMT2C KMT2D

9.37e-06444234645806
Pubmed

Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.

NOTCH2NLB NOTCH2

9.37e-06444232330268
Pubmed

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

KMT2D KMT2B

9.37e-06444220808952
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C KMT2D

9.37e-06444228398509
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2C KMT2D

9.37e-06444224081332
Pubmed

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

KMT2D KMT2B

9.37e-06444223826075
Pubmed

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

NOTCH2NLB NOTCH2

1.56e-05544229856954
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2D KMT2B

1.56e-05544226320581
Pubmed

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

KMT2C KMT2D

1.56e-05544232601106
Pubmed

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

KMT2C KMT2D

1.56e-05544231127101
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP2 SORL1

1.56e-05544219047013
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2D KMT2B

1.56e-05544228609655
Pubmed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

KMT2C KMT2D

1.56e-05544226744420
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

KMT2C KMT2D KMT2B

2.25e-054344333472061
Pubmed

MLL associates specifically with a subset of transcriptionally active target genes.

KMT2D KMT2B

2.34e-05644216199523
Pubmed

Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.

SPRY1 SPRED3

2.34e-05644229501879
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

KMT2D KMT2B

2.34e-05644224176642
Pubmed

Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.

SPRY1 SPRED3

2.34e-05644225576668
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KMT2C SUZ12 KMT2B

2.41e-054444324183668
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

PXN KMT2C RNF31 CRIP3 PLXNC1 PLXNA2 CRIP2

2.83e-0570944722988430
Pubmed

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.

KMT2D KMT2B

3.27e-05744223995757
Pubmed

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.

KMT2C KMT2D

3.27e-05744236598580
Pubmed

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.

KMT2C KMT2B

3.27e-05744219433796
Pubmed

Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.

KMT2D KMT2B

3.27e-05744216540515
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

KMT2C KMT2D KMT2B

3.55e-055044337974198
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

LRP2 CCN4 KMT2C CFAP418 KMT2B ZZEF1 SCN3A

3.58e-0573644729676528
Pubmed

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.

KMT2C KMT2D

4.36e-05844230335158
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNC1 PLXNA2

4.36e-05844215661641
Pubmed

The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family.

CRIP3 CRIP2

4.36e-05844212128222
Pubmed

Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.

KMT2C KMT2D

4.36e-05844221447625
Pubmed

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

KMT2D KMT2B

5.60e-05944216951254
Pubmed

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

KDM2B KMT2B

6.99e-051044229276034
Pubmed

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.

KMT2C KMT2D

8.54e-051144237012455
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP2 LRP1B

8.54e-051144224639464
Pubmed

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.

PLXNA2 NOTCH2

1.02e-041244212421720
Pubmed

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

KMT2D KMT2B

1.02e-041244217707229
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNC1 PLXNA2

1.02e-041244221270798
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C KMT2D

1.21e-041344217761849
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KMT2C KMT2B

1.21e-041344224619213
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNC1 PLXNA2

1.21e-041344210520995
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP2 LRP1B

1.41e-041444215082773
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C KMT2D

1.41e-041444212482968
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

KMT2C KMT2D

1.63e-041544217925232
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

LRP2 PXN KDM2B KMT2D KMT2B

1.81e-0441844534709266
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

KMT2C KMT2B

1.86e-041644223870121
Pubmed

Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.

PLXNC1 PLXNA2

1.86e-041644217356169
Pubmed

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.

KMT2D KMT2B

1.86e-041644224788516
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

PLXNA2 NOTCH2

1.86e-041644217273555
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXNC1 PLXNA2

2.10e-041744211683995
Pubmed

Identification of PSD-95 palmitoylating enzymes.

ZDHHC17 ZDHHC23

2.10e-041744215603741
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNC1 PLXNA2

2.10e-041744217626059
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

LRP2 SCN3A

2.36e-041844210827173
Pubmed

Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.

SPRY1 NOTCH2

2.64e-041944234150743
Pubmed

The ULK1-FBXW5-SEC23B nexus controls autophagy.

FBXO16 KDM2B

2.93e-042044230596474
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

KMT2C KMT2D

2.93e-042044229785026
Pubmed

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.

KMT2C KMT2D

2.93e-042044233431871
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP2 LRP1B

3.24e-042144221337463
Pubmed

Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.

PLXNC1 PLXNA2

3.56e-042244218628988
Pubmed

Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.

SPRY1 SPRED3

3.89e-042344220934536
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

KDM2B KMT2C KMT2D SUZ12 KMT2B

3.93e-0449544527705803
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

KDM2B KMT2D SUZ12 KMT2B NOTCH2 WDR44

4.09e-0477444615302935
InteractionFOXD4L6 interactions

ZDHHC17 RNF31 LRP1B NOTCH2 SORL1

4.83e-0849415int:FOXD4L6
InteractionEGFL6 interactions

LRP2 ZZEF1 LRP1B SORL1

8.60e-0821414int:EGFL6
InteractionSULF2 interactions

LRP2 G2E3 BRD1 ZZEF1 LRP1B NOTCH2

1.42e-07119416int:SULF2
InteractionNTN5 interactions

LRP2 LRP1B NOTCH2 SORL1

1.52e-0724414int:NTN5
InteractionFEZF1 interactions

LRP2 ZZEF1 LRP1B SORL1

2.91e-0728414int:FEZF1
InteractionIGFL3 interactions

LRP2 LRP1B PLXNA2 NOTCH2 SORL1

4.21e-0775415int:IGFL3
InteractionH3C14 interactions

KDM2B KMT2C KMT2D SUZ12 KMT2B BRD1

7.02e-07156416int:H3C14
InteractionGREM2 interactions

LRP2 ZZEF1 NOTCH2 SORL1

9.27e-0737414int:GREM2
InteractionTIMP3 interactions

LRP2 ZZEF1 LRP1B NOTCH2 SORL1

1.05e-0690415int:TIMP3
InteractionZNF146 interactions

SUZ12 BRD1 RNF31 NOTCH2 AMIGO1

1.11e-0691415int:ZNF146
InteractionATN1 interactions

LRP2 KMT2C KMT2B RNF31 MEGF8 CRIP2

2.02e-06187416int:ATN1
InteractionPATE1 interactions

ZZEF1 LRP1B PLXNA2 SORL1

2.92e-0649414int:PATE1
InteractionDKK2 interactions

LRP2 ZZEF1 LRP1B SORL1

2.92e-0649414int:DKK2
InteractionDPY30 interactions

PXN KMT2C KMT2D SUZ12 KMT2B BRD1

3.35e-06204416int:DPY30
InteractionRSPO1 interactions

ZZEF1 LRP1B SORL1

3.50e-0615413int:RSPO1
InteractionZFP41 interactions

LRP2 LRP1B NOTCH2 SORL1

5.39e-0657414int:ZFP41
InteractionDEFB125 interactions

LRP2 ZZEF1 DEFB125

8.70e-0620413int:DEFB125
InteractionZNF224 interactions

LRP2 LRP1B SORL1

8.70e-0620413int:ZNF224
InteractionSPRED3 interactions

ZDHHC17 SPRED3

1.21e-053412int:SPRED3
InteractionWNT2 interactions

ZZEF1 NOTCH2 SORL1

1.35e-0523413int:WNT2
InteractionLRP2 interactions

LRP2 BRD1 LRP1B DEFB125 SCN3A

1.47e-05154415int:LRP2
InteractionFBXO2 interactions

LRP2 MEGF8 LRP1B PLXNC1 PLXNA2 NOTCH2 SORL1

1.72e-05411417int:FBXO2
InteractionZNF517 interactions

LRP2 LRP1B SORL1

2.75e-0529413int:ZNF517
InteractionNDP interactions

LRP1B PLXNA2 SORL1

4.89e-0535413int:NDP
InteractionSPRY3 interactions

SPRY1 ZDHHC17 HR

4.89e-0535413int:SPRY3
InteractionDLK1 interactions

ZDHHC17 ZZEF1 NOTCH2 WDR44

5.22e-05101414int:DLK1
InteractionPGAP2 interactions

FNDC9 CGRRF1 AMIGO1

1.05e-0445413int:PGAP2
InteractionGLI4 interactions

LRP2 LRP1B NOTCH2 SORL1

1.20e-04125414int:GLI4
InteractionPAGR1 interactions

KMT2C KMT2D KMT2B

1.52e-0451413int:PAGR1
InteractionC9orf163 interactions

RNF31 ZZEF1 NOTCH2

1.52e-0451413int:C9orf163
InteractionTAFA4 interactions

LRP2 PLXNA2 SORL1

1.91e-0455413int:TAFA4
InteractionZNF408 interactions

LRP2 LRP1B NOTCH2 SORL1

2.12e-04145414int:ZNF408
InteractionRNF123 interactions

LRP2 CCN4 KMT2C CFAP418 KMT2B ZZEF1 DEFB125 SCN3A

2.17e-04824418int:RNF123
InteractionPGA4 interactions

FNDC9 AMIGO1

2.20e-0411412int:PGA4
InteractionCHRDL1 interactions

ZZEF1 LRP1B

2.20e-0411412int:CHRDL1
InteractionHNF4A interactions

KDM2B KMT2C KMT2D SUZ12 KMT2B

2.29e-04275415int:HNF4A
InteractionEDDM3B interactions

FNDC9 PLXNA2 AMIGO1

2.47e-0460413int:EDDM3B
InteractionANKRD36B interactions

LRP2 LRP1B SORL1

2.47e-0460413int:ANKRD36B
InteractionTNRC6A interactions

PXN KMT2C SUZ12 KMT2B RNF31

2.49e-04280415int:TNRC6A
InteractionZNF563 interactions

LRP1B SORL1

2.63e-0412412int:ZNF563
InteractionSSX1 interactions

KDM2B CRIP2

3.11e-0413412int:SSX1
InteractionFBN2 interactions

BRD1 DEFB125 NOTCH2

3.13e-0465413int:FBN2
InteractionKDM6A interactions

KMT2C KMT2D SUZ12 KMT2B

3.23e-04162414int:KDM6A
InteractionGCM1 interactions

KDM2B KMT2C KMT2D

3.57e-0468413int:GCM1
InteractionRNASE4 interactions

LRP1B NOTCH2

3.62e-0414412int:RNASE4
InteractionSP7 interactions

KDM2B KMT2C KMT2D KMT2B SORL1

3.63e-04304415int:SP7
InteractionKMT2D interactions

KMT2C KMT2D SUZ12 KMT2B

3.79e-04169414int:KMT2D
InteractionSETD1A interactions

KMT2C KMT2D SUZ12 KMT2B

3.88e-04170414int:SETD1A
InteractionH3C1 interactions

PXN KDM2B KMT2C KMT2D SUZ12 KMT2B BRD1 ZZEF1

3.97e-04901418int:H3C1
InteractionTEAD1 interactions

KDM2B KMT2C KMT2D ZDHHC17

4.42e-04176414int:TEAD1
InteractionPTPRK interactions

MEGF8 LRP1B PLXNA2 AMIGO1

4.52e-04177414int:PTPRK
InteractionDEFB123 interactions

LRP1B SORL1

4.76e-0416412int:DEFB123
InteractionSCN3A interactions

LRP2 SCN3A

4.76e-0416412int:SCN3A
InteractionSETD1B interactions

KMT2C KMT2D KMT2B

4.77e-0475413int:SETD1B
InteractionLHX3 interactions

KDM2B KMT2C KMT2D PLXNC1

5.34e-04185414int:LHX3
InteractionTAFA3 interactions

LRP2 LRP1B SORL1

5.35e-0478413int:TAFA3
InteractionHNF1A interactions

KDM2B KMT2C KMT2D

5.76e-0480413int:HNF1A
InteractionCLDN11 interactions

FNDC9 AMIGO1

6.05e-0418412int:CLDN11
InteractionSOX7 interactions

KDM2B KMT2C KMT2D

6.19e-0482413int:SOX7
InteractionMPPE1 interactions

CGRRF1 PLXNA2 AMIGO1

6.64e-0484413int:MPPE1
InteractionCCN6 interactions

NOTCH2 SORL1

6.76e-0419412int:CCN6
InteractionPAX2 interactions

KDM2B KMT2C KMT2D

6.88e-0485413int:PAX2
InteractionIRF4 interactions

KDM2B KMT2C KMT2D

6.88e-0485413int:IRF4
InteractionGSC interactions

KDM2B KMT2C KMT2D

7.36e-0487413int:GSC
InteractionSP6 interactions

RNF31 SORL1

7.50e-0420412int:SP6
InteractionFEV interactions

KDM2B KMT2C KMT2D KMT2B

7.56e-04203414int:FEV
InteractionCST6 interactions

CFAP418 ZDHHC23 NOTCH2

8.12e-0490413int:CST6
InteractionTAFAZZIN interactions

MEGF8 LRP1B PLXNA2 SORL1

8.13e-04207414int:TAFAZZIN
InteractionAOPEP interactions

SUZ12 ZDHHC17

8.27e-0421412int:AOPEP
InteractionAMIGO3 interactions

ZDHHC17 AMIGO1

8.27e-0421412int:AMIGO3
InteractionMDK interactions

LRP2 NOTCH2 SORL1

8.39e-0491413int:MDK
InteractionHCFC2 interactions

KMT2C KMT2D KMT2B

8.66e-0492413int:HCFC2
InteractionFOXI1 interactions

KDM2B KMT2C KMT2D

8.66e-0492413int:FOXI1
InteractionRLN1 interactions

LRP1B PLXNA2 SORL1

8.93e-0493413int:RLN1
InteractionZNF341 interactions

ZDHHC17 NOTCH2

9.09e-0422412int:ZNF341
InteractionSOX17 interactions

KDM2B KMT2C KMT2D

9.50e-0495413int:SOX17
InteractionSEMA6D interactions

PLXNC1 PLXNA2

9.94e-0423412int:SEMA6D
InteractionFAM81A interactions

SUZ12 ZZEF1

9.94e-0423412int:FAM81A
InteractionUTY interactions

KMT2C KMT2D

9.94e-0423412int:UTY
InteractionSOX9 interactions

KDM2B KMT2C KMT2D

1.01e-0397413int:SOX9
InteractionHHATL interactions

FNDC9 AMIGO1

1.08e-0324412int:HHATL
InteractionNFIX interactions

KDM2B KMT2C KMT2D KMT2B

1.14e-03227414int:NFIX
InteractionLHX1 interactions

KDM2B KMT2C KMT2D

1.20e-03103413int:LHX1
InteractionBUB3 interactions

KMT2C KMT2D SUZ12 KMT2B

1.24e-03232414int:BUB3
InteractionSYT1 interactions

LRP2 ZDHHC17 LRP1B

1.27e-03105413int:SYT1
InteractionADAM32 interactions

PRORP PLXNA2

1.27e-0326412int:ADAM32
Cytoband12q24.31

PXN KDM2B

2.71e-038044212q24.31
Cytoband6p21.1

TCTE1 CRIP3

2.71e-03804426p21.1
GeneFamilyPHD finger proteins

KDM2B KMT2C G2E3 KMT2D KMT2B BRD1

1.28e-089033688
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2D KMT2B

3.19e-0534333487
GeneFamilyPlexins

PLXNC1 PLXNA2

1.15e-049332683
GeneFamilyLIM domain containing

PXN CRIP3 CRIP2

1.68e-04593331218
GeneFamilyZinc fingers CXXC-type

KDM2B KMT2B

2.11e-0412332136
GeneFamilyLow density lipoprotein receptors

LRP2 LRP1B

2.49e-0413332634
GeneFamilyZinc fingers DHHC-type|Ankyrin repeat domain containing

ZDHHC17 ZDHHC23

8.70e-042433276
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 GPR20 NOTCH2NLB RNF31

2.06e-0516444443630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 GPR20 NOTCH2NLB RNF31

2.06e-05164444108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCN4 GPR20 NOTCH2NLB RNF31

2.06e-0516444446208f18325976c89f572f6627aea0582142b92d
ToppCellE18.5-samps-Mesenchymal-Pericyte|E18.5-samps / Age Group, Lineage, Cell class and subclass

TCTE1 CCN4 GPR20 CGRRF1

2.97e-051804440b1d370db64862fe1c7ea0ffaf06d03ec82e6e70
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM63C NOTCH2NLB NOTCH2 SORL1

2.97e-051804448ba9bba0c9fecf184a4332ba4585fb2439f68cd3
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM63C NOTCH2NLB NOTCH2 SORL1

3.10e-05182444e98ca9df33a1a81fc83ecf73d5141a14f2bc985c
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1B SPRED3 SCN3A HR

3.30e-05185444eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCellfacs-Lung-EPCAM-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 NOTCH2 SCN3A SORL1

3.37e-051864447c4eb769574f9f32753cea1cc38c711dabba88b9
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRY1 GPR20 LRP1B CRIP2

3.90e-05193444f27e2be497745098b5269aa799dd3d5f62d78ba7
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRY1 GPR20 LRP1B CRIP2

3.90e-051934444ccf984baebbb13ae916727137ce593fda7514a2
ToppCellBronchus_Control_(B.)-Stromal-TX-Smooth_muscle-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CCN4 GPR20 SCN3A HR

4.30e-051984440f1feed8a37293ae02465909f99548ab58dc7ce5
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CCN4 GPR20 LRP1B CRIP2

4.39e-05199444a207b4891881149d4c50721310690fd794157723
ToppCellSepsis-ICU-SEP-Myeloid-cDC2|ICU-SEP / Disease, condition lineage and cell class

CFAP418 NOTCH2NLB CRIP3 CGRRF1

4.48e-0520044409d5c3a3d2b42b15c769dc2bc14b6c0d5cc38f91
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

1.61e-062382DOID:0080598 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

LRP2 KMT2C KMT2D KMT2B

1.90e-0669384DOID:1682 (implicated_via_orthology)
DiseaseSquamous cell carcinoma of esophagus

KMT2C KMT2D NOTCH2

2.51e-0495383C0279626
Diseasesupramarginal gyrus volume measurement

ADORA2A-AS1 PRORP

4.38e-0424382EFO_0010332
DiseaseSezary Syndrome

KMT2C KMT2D

5.55e-0427382C0036920
Diseaselung non-small cell carcinoma (is_implicated_in)

KMT2C KMT2D LRP1B

7.65e-04139383DOID:3908 (is_implicated_in)
DiseaseBladder Neoplasm

KMT2C KMT2D NOTCH2

7.81e-04140383C0005695
DiseaseMalignant neoplasm of urinary bladder

KMT2C KMT2D NOTCH2

7.97e-04141383C0005684
Diseasepack-years measurement, systolic blood pressure

LRP2 LRP1B

8.83e-0434382EFO_0006335, EFO_0006526
Diseaseprostate cancer (is_marker_for)

KMT2C KMT2D KMT2B

1.07e-03156383DOID:10283 (is_marker_for)
DiseaseProstatic Neoplasms

LRP2 KMT2C KMT2D RNF31 LRP1B

1.11e-03616385C0033578
DiseaseMalignant neoplasm of prostate

LRP2 KMT2C KMT2D RNF31 LRP1B

1.11e-03616385C0376358
Diseaseleft ventricular systolic function measurement

PXN LRP1B

1.48e-0344382EFO_0008206
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2C KMT2D

1.54e-0345382DOID:3748 (is_implicated_in)
Diseaselung adenocarcinoma (is_implicated_in)

KMT2C LRP1B

1.83e-0349382DOID:3910 (is_implicated_in)
DiseaseDiffuse Large B-Cell Lymphoma

KMT2D NOTCH2

2.30e-0355382C0079744
Diseasehepcidin:ferritin ratio

LRP1B AMIGO1

2.30e-0355382EFO_0007901

Protein segments in the cluster

PeptideGeneStartEntry
WLCRHCLQSRARPAD

BRD1

256

O95696
CRCWCRGVEKPSSHQ

AMIGO1

396

Q86WK6
CRQPACARAVCAFVW

GPR20

161

Q99678
IHKVCRWQGCTRPAL

ADORA2A-AS1

131

P86434
NISWRACDHLRCIAC

CFAP418

121

Q96NL8
RRVSIPGHCCEQWVC

CCN4

171

O95388
WLCCATPAHALQCRD

NOTCH2NLB

16

P0DPK3
WLCCAAPAHALQCRD

NOTCH2

16

Q04721
WLRCCMHRWPVCHVA

TCTE1

131

Q5JU00
AALRPQWCCHCKVVI

KMT2C

4191

Q8NEZ4
RCKNRHCIQARWKCD

LRP1B

851

Q9NZR2
FKCQNNRCIPKRWLC

LRP1B

891

Q9NZR2
RCILNEKGDLRCHCW

LRP1B

4226

Q9NZR2
ICLQFWCVRCHEPRW

FNDC9

131

Q8TBE3
CRHGKLCWLQVATNC

EXD1

111

Q8NHP7
TKPWCVRVWHCSRCL

IL17RE

66

Q8NFR9
IRIHPCARLCFCKCW

TMEM63C

291

Q9P1W3
HWRCPRCSHRLCVAC

HR

611

O43593
RCHWCKYRNLCTHDP

PLXNA2

671

O75051
CAWCKSARRCIHPFT

PLXNC1

606

O60486
KCWKNNVGHCRRRCL

DEFB125

26

Q8N687
QCALCLRRPHCGWCA

MEGF8

2126

Q7Z7M0
HCLYSCHWRKCPRER

GDPD2

16

Q9HCC8
PLPQHHDTWCCRRCK

KMT2B

1236

Q9UMN6
KRRHWICSACVRCKS

KMT2B

1291

Q9UMN6
RCKNHHCIPLRWQCD

LRP2

3726

P98164
LNTLWHPECFVCREC

PXN

491

P49023
RSPCCKNAWFHRDCL

G2E3

161

Q7L622
CCDKRLWTRIDLNHC

KDM2B

1096

Q8NHM5
GRNWHRPCLRCQRCH

CRIP3

141

Q6Q6R5
WHRPCLRCERCGKTL

CRIP2

146

P52943
PRSLCRCAQVCWHWK

FBXO16

106

Q8IX29
TVNWVLLPCRHTCLC

CGRRF1

281

Q99675
CENGHCIPNRWKCDR

SORL1

1376

Q92673
QCRCSWHRFLRCVLT

SLC26A8

61

Q96RN1
CAVWRSLPCRLTHSC

FAM120AOS

146

Q5T036
CVCKINDDCTLPRWH

SCN3A

911

Q9NY46
ERCSCEVPTKWLCLH

PRORP

566

O15091
WAVLCVACDRPRGCK

RNF31

316

Q96EP0
CCYAPLRACHWVAAR

SPRED3

381

Q2MJR0
DDLHCPWCTLNCRKL

SUZ12

446

Q15022
RLWHISRRECLCCFQ

WDR44

631

Q5JSH3
KLCRRCYDWIHRPGC

SPRY1

281

O43609
CAKCQLVRPARAWHC

ZDHHC23

261

Q8IYP9
CNRCIAKFDHHCPWV

ZDHHC17

456

Q8IUH5
CDEIAPWHRYRCLQC

ZZEF1

1786

O43149
PAHSWKCKACRVCRA

KMT2D

311

O14686