Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	AP1AR PRICKLE4 CORO1A SETD2 BIN1 NRCAM CENPF MYO7A KIF19 APBB1 COBL PLEKHH2 USH2A PICALM HOMER2 KLHL20 PACSIN2	9.69e-06	1099	92	17	GO:0008092
GeneOntologyBiologicalProcess	endocytosis	PIKFYVE CORO1A BIN1 CD177 MYO7A ITSN1 ARHGAP12 ARFGAP1 SIGLEC5 RABGEF1 PICALM RUBCN PACSIN2 NECAP1	1.51e-05	827	91	14	GO:0006897
GeneOntologyBiologicalProcess	regulation of endocytosis	BIN1 CD177 ITSN1 ARFGAP1 SIGLEC5 RABGEF1 PICALM RUBCN PACSIN2	5.52e-05	389	91	9	GO:0030100
GeneOntologyBiologicalProcess	import into cell	PIKFYVE CORO1A BIN1 CD177 MYO7A ITSN1 ARHGAP12 ARFGAP1 SIGLEC5 RABGEF1 SLC29A2 PICALM RUBCN PACSIN2 NECAP1	6.75e-05	1074	91	15	GO:0098657
GeneOntologyBiologicalProcess	phagolysosome assembly	PIKFYVE CORO1A MYO7A	7.65e-05	19	91	3	GO:0001845
GeneOntologyCellularComponent	cell leading edge	CORO1A DUOXA1 CD177 ITSN1 APBB1 COBL PLEKHH2 USH2A CIT PACSIN2	6.36e-05	500	91	10	GO:0031252
GeneOntologyCellularComponent	postsynaptic density	ZDHHC2 NRCAM ARFGAP1 ANKS1B MAP3K7 PICALM HOMER2 HOMER1 EPHA4	1.53e-04	451	91	9	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	ZDHHC2 NRCAM ARFGAP1 ANKS1B MAP3K7 PICALM HOMER2 HOMER1 EPHA4	2.33e-04	477	91	9	GO:0032279
GeneOntologyCellularComponent	stereocilium	CORO1A MYO7A USH2A HOMER2	2.34e-04	69	91	4	GO:0032420
GeneOntologyCellularComponent	postsynaptic specialization	ZDHHC2 NRCAM ARFGAP1 ANKS1B MAP3K7 PICALM HOMER2 HOMER1 EPHA4	3.44e-04	503	91	9	GO:0099572
GeneOntologyCellularComponent	stereocilium bundle	CORO1A MYO7A USH2A HOMER2	3.93e-04	79	91	4	GO:0032421
GeneOntologyCellularComponent	neuron to neuron synapse	ZDHHC2 NRCAM ARFGAP1 ANKS1B MAP3K7 PICALM HOMER2 HOMER1 EPHA4	4.56e-04	523	91	9	GO:0098984
GeneOntologyCellularComponent	stereocilia coupling link	MYO7A USH2A	5.16e-04	8	91	2	GO:0002139
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	PTPRA APBB1 ANKS1B PICALM EPHA4	5.85e-04	155	91	5	GO:0098685
GeneOntologyCellularComponent	somatodendritic compartment	BOC BIN1 ITSN1 APBB1 ANKS1B COBL RABGEF1 USH2A CIT PICALM HOMER2 HOMER1 KLHL20 EPHA4	8.28e-04	1228	91	14	GO:0036477
GeneOntologyCellularComponent	glutamatergic synapse	PRUNE2 CORO1A BIN1 NRCAM ITSN1 APBB1 ANKS1B HOMER2 HOMER1 PACSIN2 EPHA4	8.33e-04	817	91	11	GO:0098978
GeneOntologyCellularComponent	actin cytoskeleton	PRICKLE4 CORO1A BIN1 MYO7A ITSN1 COBL PLEKHH2 CIT KLHL20	9.07e-04	576	91	9	GO:0015629
GeneOntologyCellularComponent	axonal growth cone	BOC COBL EPHA4	9.92e-04	45	91	3	GO:0044295
GeneOntologyCellularComponent	early endosome	PIKFYVE AP1AR CORO1A RABGEF1 PICALM RUBCN PACSIN2 EPHA4	1.19e-03	481	91	8	GO:0005769
GeneOntologyCellularComponent	actin-based cell projection	CORO1A MYO7A APBB1 USH2A HOMER2 EPHA4	1.36e-03	278	91	6	GO:0098858
GeneOntologyCellularComponent	postsynapse	ZDHHC2 BIN1 NRCAM ITSN1 ARFGAP1 APBB1 ANKS1B MAP3K7 PICALM HOMER2 HOMER1 EPHA4	1.51e-03	1018	91	12	GO:0098794
GeneOntologyCellularComponent	endosome	ZDHHC2 PIKFYVE AP1AR CORO1A BIN1 ITSN1 RABGEF1 MMP14 MAP3K7 PICALM RUBCN PACSIN2 EPHA4	1.59e-03	1167	91	13	GO:0005768
GeneOntologyCellularComponent	axon	BOC CORO1A BIN1 NRCAM ITSN1 APBB1 COBL USH2A HOMER1 KLHL20 EPHA4	1.67e-03	891	91	11	GO:0030424
GeneOntologyCellularComponent	cell body	PITPNM1 BOC ITSN1 APBB1 COBL USH2A CIT PICALM HOMER2 HOMER1 EPHA4	2.32e-03	929	91	11	GO:0044297
GeneOntologyCellularComponent	presynaptic endocytic zone	ITSN1 PICALM	2.74e-03	18	91	2	GO:0098833
GeneOntologyCellularComponent	distal axon	BOC BIN1 ITSN1 APBB1 COBL USH2A EPHA4	2.91e-03	435	91	7	GO:0150034
GeneOntologyCellularComponent	lamellipodium	CORO1A CD177 ITSN1 APBB1 PLEKHH2	3.33e-03	230	91	5	GO:0030027
GeneOntologyCellularComponent	node of Ranvier	BIN1 NRCAM	3.38e-03	20	91	2	GO:0033268
GeneOntologyCellularComponent	neuronal cell body	BOC ITSN1 APBB1 COBL USH2A CIT PICALM HOMER2 HOMER1 EPHA4	3.39e-03	835	91	10	GO:0043025
GeneOntologyCellularComponent	stereocilium tip	CORO1A HOMER2	4.09e-03	22	91	2	GO:0032426
GeneOntologyCellularComponent	dendrite	BIN1 ITSN1 APBB1 ANKS1B COBL RABGEF1 HOMER2 HOMER1 KLHL20 EPHA4	4.11e-03	858	91	10	GO:0030425
GeneOntologyCellularComponent	dendritic spine	ITSN1 APBB1 ANKS1B HOMER1 EPHA4	4.14e-03	242	91	5	GO:0043197
GeneOntologyCellularComponent	dendritic tree	BIN1 ITSN1 APBB1 ANKS1B COBL RABGEF1 HOMER2 HOMER1 KLHL20 EPHA4	4.18e-03	860	91	10	GO:0097447
GeneOntologyCellularComponent	neuron spine	ITSN1 APBB1 ANKS1B HOMER1 EPHA4	4.51e-03	247	91	5	GO:0044309
Domain	-	MYO7A ITSN1 ARHGAP12 APBB1 ANKS1B PLEKHH2 CIT HOMER2 HOMER1 NECAP1	2.05e-05	391	91	10	2.30.29.30
Domain	PH_dom-like	MYO7A ITSN1 ARHGAP12 APBB1 ANKS1B PLEKHH2 CIT HOMER2 HOMER1 NECAP1	4.25e-05	426	91	10	IPR011993
Domain	Ago_hook	TNRC6A TNRC6B	7.02e-05	3	91	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6A TNRC6B	7.02e-05	3	91	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6A TNRC6B	7.02e-05	3	91	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6A TNRC6B	7.02e-05	3	91	2	PF16608
Domain	WW	SETD2 WWP1 ARHGAP12 APBB1	8.01e-05	47	91	4	PF00397
Domain	WW	SETD2 WWP1 ARHGAP12 APBB1	8.71e-05	48	91	4	SM00456
Domain	SH3	TNK1 BIN1 MYO7A ITSN1 ARHGAP12 PPP1R13B PACSIN2	8.93e-05	216	91	7	SM00326
Domain	SH3	TNK1 BIN1 MYO7A ITSN1 ARHGAP12 PPP1R13B PACSIN2	8.93e-05	216	91	7	PS50002
Domain	SH3_domain	TNK1 BIN1 MYO7A ITSN1 ARHGAP12 PPP1R13B PACSIN2	1.00e-04	220	91	7	IPR001452
Domain	WW_DOMAIN_2	SETD2 WWP1 ARHGAP12 APBB1	1.11e-04	51	91	4	PS50020
Domain	WW_DOMAIN_1	SETD2 WWP1 ARHGAP12 APBB1	1.11e-04	51	91	4	PS01159
Domain	WW_dom	SETD2 WWP1 ARHGAP12 APBB1	1.19e-04	52	91	4	IPR001202
Domain	MYTH4	MYO7A PLEKHH2	8.27e-04	9	91	2	PS51016
Domain	MyTH4_dom	MYO7A PLEKHH2	8.27e-04	9	91	2	IPR000857
Domain	MyTH4	MYO7A PLEKHH2	8.27e-04	9	91	2	PF00784
Domain	MyTH4	MYO7A PLEKHH2	8.27e-04	9	91	2	SM00139
Domain	SH3_1	BIN1 ITSN1 ARHGAP12 PPP1R13B PACSIN2	1.24e-03	164	91	5	PF00018
Domain	WH1	HOMER2 HOMER1	1.25e-03	11	91	2	SM00461
Domain	WH1/EVH1_dom	HOMER2 HOMER1	1.25e-03	11	91	2	IPR000697
Domain	WH1	HOMER2 HOMER1	1.25e-03	11	91	2	PF00568
Domain	WD40	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	1.67e-03	259	91	6	PF00400
Domain	WH1	HOMER2 HOMER1	1.77e-03	13	91	2	PS50229
Domain	WD40	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	1.99e-03	268	91	6	SM00320
Domain	CNH	MAP4K3 CIT	2.06e-03	14	91	2	SM00036
Domain	WD40_repeat	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	2.14e-03	272	91	6	IPR001680
Domain	CNH	MAP4K3 CIT	2.37e-03	15	91	2	PF00780
Domain	CNH	MAP4K3 CIT	2.37e-03	15	91	2	PS50219
Domain	CNH_dom	MAP4K3 CIT	2.37e-03	15	91	2	IPR001180
Domain	WD_REPEATS_1	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	2.39e-03	278	91	6	PS00678
Domain	WD_REPEATS_2	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	2.43e-03	279	91	6	PS50082
Domain	WD_REPEATS_REGION	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	2.43e-03	279	91	6	PS50294
Domain	Protein_kinase_ATP_BS	TNK1 TAOK3 LATS2 MAP4K3 MAP3K7 CIT EPHA4	2.52e-03	379	91	7	IPR017441
Domain	WD40_repeat_dom	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	3.31e-03	297	91	6	IPR017986
Domain	UBA-like	LATS2 TNRC6A TNRC6B	3.76e-03	64	91	3	IPR009060
Domain	SEA	MUC16 MUC12	5.09e-03	22	91	2	PF01390
Domain	SEA	MUC16 MUC12	5.56e-03	23	91	2	PS50024
Domain	SEA_dom	MUC16 MUC12	5.56e-03	23	91	2	IPR000082
Domain	-	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	5.76e-03	333	91	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	5.92e-03	335	91	6	IPR015943
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	BIN1 ITSN1 ARFGAP1 PICALM PACSIN2 NECAP1	5.20e-05	142	66	6	MM15499
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	BIN1 ITSN1 ARFGAP1 PICALM PACSIN2 NECAP1	5.84e-05	145	66	6	M27753
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	LATS2 ITSN1 ARFGAP1 TNRC6A APBB1 PPP1R13B TNRC6B HELZ NUP42 PICALM	2.16e-09	263	92	10	34702444
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	PIKFYVE PRUNE2 AP1AR ITSN1 COBL FAM91A1 RABGEF1 PICALM RUBCN DMXL1	4.65e-09	285	92	10	34369648
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	BIN1 CENPF ITSN1 APBB1 PPP1R13B COBL PACSIN2	3.35e-08	120	92	7	31413325
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	BIN1 NRCAM CENPF NHSL2 ITSN1 ANKS1B TNRC6B RABGEF1 CIT PICALM HOMER2 HOMER1 RAI1 TBL1X EPHA4	3.48e-08	963	92	15	28671696
Pubmed	A human MAP kinase interactome.	MAP4K3 ITSN1 TNRC6A PPP1R13B COBL HELZ NKTR MUC12 NUP42 MAP3K7 PACSIN2	6.89e-08	486	92	11	20936779
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PITPNM1 CORO1A BIN1 NRCAM ARFGAP1 TNRC6A APBB1 ANKS1B TNRC6B HELZ FAM91A1 RABGEF1 MAP3K7 CIT HOMER1	3.02e-07	1139	92	15	36417873
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PITPNM1 SETD2 BIN1 GCFC2 ITSN1 ARFGAP1 HELZ FAM91A1 MED1 WRAP53 KLHDC4 KDM6A	9.67e-07	774	92	12	15302935
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	PIKFYVE CORO1A MAP4K3 TNRC6A PPP1R13B TNRC6B MAP3K7	1.93e-06	218	92	7	33378226
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	AP1AR PTPRA LATS2 WWP1 MPZL1 APBB1 COBL SLC29A2 PACSIN2 EPHA4	2.75e-06	569	92	10	30639242
Pubmed	Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells.	CIT HOMER2 HOMER1	2.91e-06	11	92	3	10493740
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	ZDHHC2 BIN1 NHSL2 MAP4K3 WWP1 ARFGAP1 MPZL1 TNRC6A COBL FAM91A1 PACSIN2	3.22e-06	719	92	11	35337019
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	PTPRA NRCAM TIAL1 MYO7A WWP1 HELZ NUP42 EPHA4	5.12e-06	358	92	8	32460013
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE C2CD3 LATS2 MYO7A WWP1 COBL LTBP3 WRAP53 MMP14 PPP2R3C SLC29A2 CIT RAI1	6.85e-06	1105	92	13	35748872
Pubmed	Role of GW182 protein in the cell.	TNRC6A TNRC6B	6.92e-06	2	92	2	29791863
Pubmed	MYO7A and USH2A gene sequence variants in Italian patients with Usher syndrome.	MYO7A USH2A	6.92e-06	2	92	2	25558175
Pubmed	Mutations in myosin VIIA (MYO7A) and usherin (USH2A) in Spanish patients with Usher syndrome types I and II, respectively.	MYO7A USH2A	6.92e-06	2	92	2	12112664
Pubmed	Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.	HOMER2 HOMER1	6.92e-06	2	92	2	23658151
Pubmed	Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.	MUC16 MMP14	6.92e-06	2	92	2	25205731
Pubmed	The Study of a 231 French Patient Cohort Significantly Extends the Mutational Spectrum of the Two Major Usher Genes MYO7A and USH2A.	MYO7A USH2A	6.92e-06	2	92	2	34948090
Pubmed	No association of alcohol dependence with HOMER 1 and 2 genetic variants.	HOMER2 HOMER1	6.92e-06	2	92	2	20333726
Pubmed	Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.	PTPRA MMP14	6.92e-06	2	92	2	33566639
Pubmed	Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletion.	HOMER2 HOMER1	6.92e-06	2	92	2	17553998
Pubmed	Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice.	HOMER2 HOMER1	6.92e-06	2	92	2	35008503
Pubmed	Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise.	HOMER2 HOMER1	6.92e-06	2	92	2	21885651
Pubmed	Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A.	MYO7A USH2A	6.92e-06	2	92	2	31266775
Pubmed	CLINICAL PRESENTATION AND DISEASE COURSE OF USHER SYNDROME BECAUSE OF MUTATIONS IN MYO7A OR USH2A.	MYO7A USH2A	6.92e-06	2	92	2	27828912
Pubmed	Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.	HOMER2 HOMER1	6.92e-06	2	92	2	16011574
Pubmed	Novel mutations in MYO7A and USH2A in Usher syndrome.	MYO7A USH2A	6.92e-06	2	92	2	15823922
Pubmed	Diagnostic Potential of Differentially Expressed Homer1 and Homer2 in Ischemic Stroke.	HOMER2 HOMER1	6.92e-06	2	92	2	27832625
Pubmed	Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population.	HOMER2 HOMER1	6.92e-06	2	92	2	16314758
Pubmed	Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.	BIN1 PICALM	6.92e-06	2	92	2	21220176
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	TAOK3 NWD1 TIAL1 CENPF MYO7A KIF19 COBL HOMER1 RAI1	7.03e-06	497	92	9	36774506
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	BIN1 PTPRA NRCAM SLF2 ITSN1 APBB1 ANKS1B LTBP3 NUP42 WRAP53 CIT GEN1 KDM6A ZMYM5	7.04e-06	1285	92	14	35914814
Pubmed	Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.	BIN1 ITSN1 PPP1R13B	7.96e-06	15	92	3	9630982
Pubmed	Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.	ITSN1 TNRC6B RABGEF1 PICALM	2.00e-05	60	92	4	34761192
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZDHHC2 TBX19 PPARGC1B BIN1 GCFC2 TIAL1 WWP1 MED1 TCEANC RAI1 TBL1X	2.06e-05	877	92	11	20211142
Pubmed	Homer proteins regulate sensitivity to cocaine.	HOMER2 HOMER1	2.07e-05	3	92	2	15294147
Pubmed	Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.	TNK1 PICALM	2.07e-05	3	92	2	28631188
Pubmed	The Genetics of Usher Syndrome in the Israeli and Palestinian Populations.	MYO7A USH2A	2.07e-05	3	92	2	29490346
Pubmed	Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.	HOMER2 HOMER1	2.07e-05	3	92	2	32070057
Pubmed	Mutation screening of the Homer gene family and association analysis in schizophrenia.	HOMER2 HOMER1	2.07e-05	3	92	2	12815733
Pubmed	The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning.	BIN1 PICALM	2.07e-05	3	92	2	24660791
Pubmed	PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.	HOMER2 HOMER1	2.07e-05	3	92	2	14528310
Pubmed	Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.	MUC16 MUC12	2.07e-05	3	92	2	26770020
Pubmed	Differential expression of Homer family proteins in the developing mouse brain.	HOMER2 HOMER1	2.07e-05	3	92	2	15116392
Pubmed	Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.	HOMER2 HOMER1	2.07e-05	3	92	2	24530450
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6A TNRC6B	2.07e-05	3	92	2	34108231
Pubmed	Targeted next generation sequencing in Italian patients with Usher syndrome: phenotype-genotype correlations.	MYO7A USH2A	2.07e-05	3	92	2	29142287
Pubmed	Genetic evidence for the involvement of variants at APOE, BIN1, CR1, and PICALM loci in risk of late-onset Alzheimer's disease and evaluation for interactions with APOE genotypes.	BIN1 PICALM	2.07e-05	3	92	2	25022885
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6A TNRC6B	2.07e-05	3	92	2	16880270
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6A TNRC6B	2.07e-05	3	92	2	31670606
Pubmed	LATS2 inhibits the activity of NF-κ B signaling by disrupting the interaction between TAK1 and IKKβ.	LATS2 MAP3K7	2.07e-05	3	92	2	25946971
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	ARFGAP1 TNRC6A APBB1 TNRC6B HELZ MAP3K7 GEN1	2.44e-05	322	92	7	39098523
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PIKFYVE SETD2 BIN1 GCFC2 ITSN1 MPZL1 TNRC6A TNRC6B HELZ PACSIN2	2.48e-05	733	92	10	34672954
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PIKFYVE SETD2 SLF2 ITSN1 TNRC6A PPP1R13B HELZ NUP42 PPP2R3C	2.65e-05	588	92	9	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	WWP1 ITSN1 PPP1R13B RABGEF1 LTBP3 KDM6A RUBCN SVEP1 ZMYM5	2.76e-05	591	92	9	15231748
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	PITPNM1 BIN1 NRCAM ITSN1 ARFGAP1 MAP3K7 CIT	3.92e-05	347	92	7	17114649
Pubmed	A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis.	MYO7A PICALM	4.14e-05	4	92	2	2300582
Pubmed	Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase.	BIN1 MAP4K3	4.14e-05	4	92	2	11384986
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	MYO7A USH2A	4.14e-05	4	92	2	18463160
Pubmed	Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities.	HOMER2 HOMER1	4.14e-05	4	92	2	12860966
Pubmed	Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.	LATS2 PPP1R13B	4.14e-05	4	92	2	21041411
Pubmed	Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.	SETD2 KDM6A	4.14e-05	4	92	2	20054297
Pubmed	Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC.	SETD2 KDM6A	4.14e-05	4	92	2	23644518
Pubmed	Homer regulates gain of ryanodine receptor type 1 channel complex.	HOMER2 HOMER1	4.14e-05	4	92	2	12223488
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6A TNRC6B	4.14e-05	4	92	2	21063388
Pubmed	Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.	BIN1 PICALM	4.14e-05	4	92	2	21347408
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	BIN1 TAOK3 PTPRA LATS2 MPZL1 PICALM PACSIN2	6.61e-05	377	92	7	38117590
Pubmed	Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.	BIN1 PICALM	6.89e-05	5	92	2	22539578
Pubmed	Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.	BIN1 PICALM	6.89e-05	5	92	2	21059989
Pubmed	Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome.	HOMER2 HOMER1	6.89e-05	5	92	2	34788607
Pubmed	The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.	BIN1 PICALM	6.89e-05	5	92	2	21627779
Pubmed	GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation.	CENPF TNRC6A	6.89e-05	5	92	2	15494374
Pubmed	Preso1 dynamically regulates group I metabotropic glutamate receptors.	HOMER2 HOMER1	6.89e-05	5	92	2	22561452
Pubmed	Genetic variation and neuroimaging measures in Alzheimer disease.	BIN1 PICALM	6.89e-05	5	92	2	20558387
Pubmed	Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives.	BIN1 PICALM	6.89e-05	5	92	2	27773727
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	C2CD3 MAP4K3 ITSN1 ARHGAP12 ARFGAP1 TNRC6A PPP1R13B TNRC6B COBL FAM91A1	8.79e-05	853	92	10	28718761
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	ITSN1 TNRC6A TNRC6B MAP3K7 GEN1	8.92e-05	169	92	5	31462741
Pubmed	A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.	HOMER2 HOMER1	1.03e-04	6	92	2	23911326
Pubmed	Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.	TNRC6A SVEP1	1.03e-04	6	92	2	23386860
Pubmed	TAK1 expression in the cochlea: a specific marker for adult supporting cells.	MYO7A MAP3K7	1.03e-04	6	92	2	21472480
Pubmed	Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region.	BIN1 ITSN1	1.03e-04	6	92	2	26613292
Pubmed	The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.	LATS2 PPP1R13B	1.03e-04	6	92	2	21041410
Pubmed	Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.	HOMER2 HOMER1	1.03e-04	6	92	2	9808459
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PITPNM1 NRCAM ANKS1B CIT HOMER2 HOMER1	1.05e-04	281	92	6	28706196
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	LATS2 MPZL1 TNRC6A NUP42 RAI1	1.20e-04	180	92	5	35198878
Pubmed	Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.	CYP1A2 NRCAM	1.44e-04	7	92	2	21876539
Pubmed	NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.	HOMER2 HOMER1	1.44e-04	7	92	2	18218901
Pubmed	The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells.	MYO7A USH2A	1.44e-04	7	92	2	28031293
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6A TNRC6B	1.44e-04	7	92	2	19470757
Pubmed	Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice.	LATS2 MYO7A	1.44e-04	7	92	2	33162027
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6A TNRC6B	1.44e-04	7	92	2	19383768
Pubmed	Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.	HOMER2 HOMER1	1.44e-04	7	92	2	9808458
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	ITSN1 ANKS1B CIT HOMER2 HOMER1	1.83e-04	197	92	5	36604605
Pubmed	Genome-wide analysis of genetic loci associated with Alzheimer disease.	BIN1 PICALM	1.92e-04	8	92	2	20460622
Pubmed	Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.	NUP42 MAP3K7	1.92e-04	8	92	2	26401039
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	MYO7A USH2A	1.92e-04	8	92	2	19683999
Pubmed	Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.	MYO7A MMP14	1.92e-04	8	92	2	31600777
Pubmed	UMD-USHbases: a comprehensive set of databases to record and analyse pathogenic mutations and unclassified variants in seven Usher syndrome causing genes.	MYO7A USH2A	1.92e-04	8	92	2	18484607
Pubmed	Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.	MYO7A USH2A	1.92e-04	8	92	2	16545802
Interaction	WASL interactions	BIN1 WWP1 ITSN1 ARHGAP12 APBB1 BCHE PACSIN2	1.08e-06	117	92	7	int:WASL
Interaction	ATG9A interactions	PIKFYVE PRUNE2 AP1AR ITSN1 COBL FAM91A1 RABGEF1 PICALM RUBCN KLHL20 DMXL1	5.79e-06	445	92	11	int:ATG9A
Interaction	RNF43 interactions	LATS2 ITSN1 ARFGAP1 TNRC6A APBB1 PPP1R13B TNRC6B HELZ NUP42 PICALM	2.52e-05	427	92	10	int:RNF43
Interaction	FBXO22 interactions	TAOK3 NWD1 LATS2 TIAL1 CENPF MYO7A KIF19 COBL CIT HOMER1 RAI1	3.49e-05	540	92	11	int:FBXO22
GeneFamily	Homer scaffolding proteins	HOMER2 HOMER1	3.24e-05	3	60	2	871
GeneFamily	WD repeat domain containing	CORO1A NWD1 WDR5B WRAP53 DMXL1 TBL1X	2.27e-04	262	60	6	362
GeneFamily	Fibronectin type III domain containing	BOC NRCAM USH2A EPHA4	1.96e-03	160	60	4	555
GeneFamily	CD molecules\|Mucins	MUC16 MUC12	2.18e-03	21	60	2	648
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK3 MAP3K7	2.85e-03	24	60	2	654
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6A TNRC6B	3.09e-03	25	60	2	775
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	PIKFYVE SETD2 TAOK3 C2CD3 PTPRA CENPF WWP1 ITSN1 ARHGAP12 HELZ MED1 PICALM HOMER1 KLHL20 TBL1X EPHA4	3.85e-08	856	91	16	M4500
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	PIKFYVE SETD2 C2CD3 PTPRA CENPF ITSN1 ARHGAP12 HELZ PICALM HOMER1 TBL1X EPHA4	7.68e-08	466	91	12	M13522
Coexpression	GSE13762_CTRL_VS_125_VITAMIND_DAY5_DC_UP	TBX19 PPARGC1B CD177 ARFGAP1 MUC16 HOMER2	8.11e-06	136	91	6	M1894
Coexpression	GSE6259_33D1_POS_DC_VS_CD4_TCELL_DN	PRUNE2 MYO7A SLF2 WWP1 ITSN1 DMXL1	3.50e-05	176	91	6	M6757
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1	PIKFYVE SETD2 GCFC2 CENPF MAP4K3 TNRC6B NKTR NUP42 MAP3K7 CIT KDM6A PICALM ZMYM5	2.74e-05	780	91	13	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PITPNM1 WDR5B LRRIQ1 SUOX ITSN1 EPHA4	1.31e-06	167	92	6	b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC PRUNE2 MAML2 PLEKHH2 C8orf34 TBL1X	1.78e-06	176	92	6	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC PRUNE2 MAML2 PLEKHH2 C8orf34 TBL1X	2.16e-06	182	92	6	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BOC PLEKHH2 C8orf34 HOMER1 TBL1X EPHA4	2.23e-06	183	92	6	cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZNF704 DUOXA1 PPP1R13B COBL C8orf34 CIT	2.30e-06	184	92	6	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC PRUNE2 ZNF704 ITSN1 ANKS1B LTBP3	2.37e-06	185	92	6	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BOC PRUNE2 MAML2 PLEKHH2 C8orf34 TBL1X	2.68e-06	189	92	6	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE NRCAM MAP4K3 GEN1 PACSIN2 DMXL1	2.76e-06	190	92	6	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COBL MAML2 PLEKHH2 C8orf34 HOMER1 TBL1X	2.85e-06	191	92	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NRCAM WWP1 TNRC6A APBB1 NKTR MAML2	2.85e-06	191	92	6	696921a4f160b6b55698652488ed781e855e5e51
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ZNF704 TNRC6A TNRC6B HELZ NKTR KDM6A	2.94e-06	192	92	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	LA\|World / Chamber and Cluster_Paper	LVRN PRUNE2 ANKS1B MAML2 PLEKHH2 SVEP1	3.03e-06	193	92	6	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	ZNF704 TNRC6A TNRC6B HELZ NKTR KDM6A	3.03e-06	193	92	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	NRCAM MYO7A BCHE PLEKHH2 MMP14 SVEP1	3.71e-06	200	92	6	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	NRCAM MYO7A BCHE PLEKHH2 MMP14 SVEP1	3.71e-06	200	92	6	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LRRIQ1 SUOX MYO7A ITSN1 EPHA4	1.87e-05	157	92	5	432b8719a8afd289cf48068e12c26a349d753fcc
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BOC NHSL2 SIGLEC5 PLEKHH2 SVEP1	1.87e-05	157	92	5	f147e24f2ece82e1c54750868954d09b3c461804
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BOC NHSL2 SIGLEC5 PLEKHH2 SVEP1	1.93e-05	158	92	5	e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCell	Paneth_cell\|World / shred on cell type and cluster	PRUNE2 KIF19 PKD1L3 HOMER1 TBL1X	2.05e-05	160	92	5	d787b7cdb8c3f677ac9c4934a5df9cc194df3987
ToppCell	C_07\|World / shred on cell type and cluster	PRUNE2 KIF19 PKD1L3 HOMER1 TBL1X	2.05e-05	160	92	5	b7c5a8a1c85da92e1945721b6887b32fad7b76b8
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO1A CENPF MYO7A SIGLEC5 KLHDC4	2.37e-05	165	92	5	1dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRUNE2 TBX19 SIGLEC5 FAM91A1 KLHDC4	2.59e-05	168	92	5	a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ITSN1 MPZL1 SLC29A2 GEN1 KLHL20	2.82e-05	171	92	5	23b3120706bb9c20b9214fe3760c6d7a84f1e749
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	ZNF704 APBB1 PPP1R13B COBL PLEKHH2	3.14e-05	175	92	5	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BOC LRRIQ1 PLEKHH2 C8orf34 TBL1X	3.14e-05	175	92	5	284fdc7a9d303636a637041846850d19d114861a
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	BOC ZNF704 TNK1 DUOXA1 SVEP1	3.23e-05	176	92	5	bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC MAML2 C8orf34 HOMER1 TBL1X	3.32e-05	177	92	5	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BOC PRUNE2 NRCAM BCHE LTBP3	3.32e-05	177	92	5	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	PRUNE2 AP1AR WWP1 CIT GEN1	3.50e-05	179	92	5	ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BOC LRRIQ1 PLEKHH2 C8orf34 TBL1X	3.69e-05	181	92	5	6a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BOC PRUNE2 MAML2 C8orf34 TBL1X	3.89e-05	183	92	5	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	AP1AR MED1 WRAP53 TCEANC KDM6A	3.89e-05	183	92	5	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BOC PRUNE2 MAML2 C8orf34 TBL1X	3.89e-05	183	92	5	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	AP1AR MED1 WRAP53 TCEANC KDM6A	3.89e-05	183	92	5	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 CENPF MYO7A SIGLEC5 KLHDC4	4.10e-05	185	92	5	57c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LRRIQ1 MAML2 PLEKHH2 C8orf34	4.21e-05	186	92	5	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	DUOXA1 PPP1R13B C8orf34 CIT HOMER2	4.31e-05	187	92	5	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MAML2 PLEKHH2 C8orf34 TBL1X	4.42e-05	188	92	5	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF704 NRCAM PLEKHH2 MMP14 SVEP1	4.54e-05	189	92	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PITPNM1 LRRIQ1 CENPF MUC16 MUC12	4.65e-05	190	92	5	0adb24dafa077156bbc73a8d8cbf3d9eeb6e08df
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PITPNM1 LRRIQ1 CENPF MUC16 MUC12	4.65e-05	190	92	5	05455775845f4ded5c27e7b83242078d23162aaf
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	NWD1 LRRIQ1 KIF19 MUC16 C8orf34	4.77e-05	191	92	5	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PITPNM1 LRRIQ1 CENPF KIF19 MUC12	4.77e-05	191	92	5	a6c9df4cb4d09e0a91b3c8d7f3e091a7e95e6471
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	NWD1 LRRIQ1 KIF19 MUC16 C8orf34	4.77e-05	191	92	5	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	BOC ANKS1B MAML2 PLEKHH2 SVEP1	5.26e-05	195	92	5	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	facs-Skin-nan-18m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC DUOXA1 NRCAM LTBP3 SVEP1	5.26e-05	195	92	5	ba7cb80deb872c9184769f0dd57855c3c6a432bf
ToppCell	(2)_Fibroblasts-(24)_Fibro-5\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	BOC DUOXA1 WWP1 APBB1 HOMER2	5.52e-05	197	92	5	83a4b79fbfa1cf63441dee4424c3b87c988287bf
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRCAM NHSL2 PLEKHH2 MMP14 SVEP1	5.66e-05	198	92	5	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOXA1 PPP1R13B COBL C8orf34 PACSIN2	5.79e-05	199	92	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MAP4K3 TNRC6A TNRC6B MAML2 KDM6A	5.79e-05	199	92	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NRCAM BCHE PLEKHH2 MMP14 SVEP1	5.79e-05	199	92	5	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TNRC6B BCHE NKTR PLEKHH2 SVEP1	5.79e-05	199	92	5	615f20bf136dfef53b072667cf0e4df6a1017e05
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NRCAM ITSN1 PLEKHH2 MMP14 SVEP1	5.93e-05	200	92	5	b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NRCAM ITSN1 PLEKHH2 MMP14 SVEP1	5.93e-05	200	92	5	50ca6550998e461ef26dd670351060bd940765a8
ToppCell	Sigmoid-T_cell-cycling_gd_T\|T_cell / Region, Cell class and subclass	CD177 CENPF WRAP53 PKD1L3 GEN1	5.93e-05	200	92	5	4e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCell	Sigmoid-(1)_T_cell-(18)_cycling_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	CD177 CENPF WRAP53 PKD1L3 GEN1	5.93e-05	200	92	5	6e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	NRCAM BCHE PLEKHH2 MMP14 SVEP1	5.93e-05	200	92	5	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	Sigmoid-T_cell-cycling_gd_T\|Sigmoid / Region, Cell class and subclass	CD177 CENPF WRAP53 PKD1L3 GEN1	5.93e-05	200	92	5	9769185abae084ffac36420c749625e679b70ca8
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ZNF704 SUOX PKD1L3 EPHA4	1.87e-04	137	92	4	b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MSLNL NHSL2 PLEKHH2 SLCO6A1	2.44e-04	147	92	4	989a48bda98fbff398985397a6b1189a4cbc80e7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MSLNL NHSL2 PLEKHH2 SLCO6A1	2.44e-04	147	92	4	f6681c849c4c06154548bd29a094f202d1c946c2
ToppCell	COVID-19_Mild-PLT_0\|World / Disease Group and Platelet Clusters	SLF2 PLEKHH2 RUBCN SVEP1	2.78e-04	152	92	4	d49f7c0681500fc4d93818d47e8e8afb726c23d9
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NWD1 LRRIQ1 KIF19 USH2A	2.92e-04	154	92	4	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NWD1 LRRIQ1 KIF19 USH2A	2.92e-04	154	92	4	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	COVID-19-lung-Mesothelial\|lung / Disease (COVID-19 only), tissue and cell type	BOC ANKS1B MUC16 BCHE	3.07e-04	156	92	4	e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	BOC NRCAM BCHE PLEKHH2	3.22e-04	158	92	4	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MALRD1 DUOXA1 C8orf34 CIT	3.29e-04	159	92	4	e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHH2 USH2A C8orf34 SVEP1	3.37e-04	160	92	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 LVRN CORO1A ARHGAP12	3.37e-04	160	92	4	8308ca6f37986c526432a0fbc5f7ec2e75cfb6d7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NWD1 MALRD1 NRCAM EPHA4	3.37e-04	160	92	4	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHH2 USH2A C8orf34 SVEP1	3.37e-04	160	92	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MAP4K3 WWP1 MMP14	3.37e-04	160	92	4	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LVRN ZNF704 CORO1A CD177	3.62e-04	163	92	4	66ecd544d7b52e61880b125bf39d1f406af6900a
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRUNE2 NRCAM BCHE LTBP3	3.70e-04	164	92	4	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	COVID-19-lung-Mesothelial\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BOC ANKS1B MUC16 BCHE	3.70e-04	164	92	4	83303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRUNE2 WDR5B WWP1 ITSN1	3.79e-04	165	92	4	47e716ce8dc283d406352c1909e09362fcb9e3a3
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRUNE2 WDR5B WWP1 ITSN1	3.79e-04	165	92	4	fe2135fdacf3807eb4b5ea5e790febfb8cd54335
ToppCell	15-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	PRUNE2 COBL BCHE EPHA4	3.79e-04	165	92	4	531804467601e1ee1f771cffa21501f6d464ae10
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	BOC NRCAM BCHE PLEKHH2	3.97e-04	167	92	4	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	droplet-Heart-nan-18m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 LVRN CD177 RABGEF1	4.06e-04	168	92	4	2201ae834b53cbdc085f8f02607fa5b5bd911268
ToppCell	Control\|World / group, cell type (main and fine annotations)	ANKS1B COBL C8orf34 PACSIN2	4.06e-04	168	92	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 LRRIQ1 KIF19 MUC16	4.15e-04	169	92	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIKFYVE BOC WDR5B HOMER2	4.24e-04	170	92	4	8465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPF MYO7A SIGLEC5 KLHDC4	4.34e-04	171	92	4	845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Deuterosomal\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PITPNM1 LRRIQ1 KIF19 MUC12	4.34e-04	171	92	4	52aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	NWD1 LRRIQ1 KIF19 MUC16	4.43e-04	172	92	4	187ae91148d293537afc77e10da2b64302322224
ToppCell	TCGA-Brain-Primary_Tumor\|TCGA-Brain / Sample_Type by Project: Shred V9	TAOK3 ARHGAP12 BCHE MAML2	4.53e-04	173	92	4	f6ba22661e67c17d49d1058d4170ba8f36bf47f0
ToppCell	LV-11._Adipocyte\|LV / Chamber and Cluster_Paper	LVRN ITSN1 C8orf34 SVEP1	4.53e-04	173	92	4	c2d3fcb3de71015d03d14c63450853d2b03ffa71
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TNK1 CORO1A SIGLEC5 RUBCN	4.63e-04	174	92	4	4120656e6d6cf5435a248326b5fdbdc7b22137af
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRCAM BCHE MAML2 PLEKHH2	4.73e-04	175	92	4	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRICKLE4 TAOK3 PTPRA WRAP53	4.73e-04	175	92	4	26bd957498e41a3f1ffa60d3effa27ca8c4ba631
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	PPARGC1B RUBCN HOMER2 RAI1	4.84e-04	176	92	4	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LTBP3 PLEKHH2 MMP14 SVEP1	4.84e-04	176	92	4	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NWD1 DUOXA1 MYO7A MMP14	4.84e-04	176	92	4	057d2759fdc67176c25802b57a78064d8cc93205
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	MALRD1 DUOXA1 C8orf34 CIT	4.84e-04	176	92	4	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NWD1 DUOXA1 MYO7A MMP14	4.84e-04	176	92	4	b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LTBP3 PLEKHH2 MMP14 SVEP1	4.84e-04	176	92	4	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MYO7A SIGLEC5 KLHDC4	4.84e-04	176	92	4	e74ad0db3b05897edcfabeb11008ede2b9eeb638
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PPARGC1B MYO7A SIGLEC5 KLHDC4	4.84e-04	176	92	4	b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNRC6B COBL PLEKHH2 SVEP1	4.94e-04	177	92	4	b7fee75de7e96924af488a5baa2334711889ae7c
Drug	Monobenzone [103-16-2]; Down 200; 20uM; MCF7; HT_HG-U133A	AP1AR NRCAM CENPF ARHGAP12 KLHL20 ZMYM5 TBL1X EPHA4	9.98e-07	189	92	8	5312_DN
Drug	Risperidone [106266-06-2]; Down 200; 9.8uM; HL60; HT_HG-U133A	PITPNM1 MAP4K3 ARFGAP1 TNRC6B NKTR KLHL20 ZMYM5 EPHA4	1.12e-06	192	92	8	2947_DN
Drug	Meclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A	SETD2 PTPRA NRCAM SLF2 ITSN1 ARFGAP1 KDM6A ZMYM5	1.53e-06	200	92	8	3405_DN
Drug	GSK-3beta Inhibitor VIII; Up 200; 10uM; PC3; HT_HG-U133A	PITPNM1 SETD2 BIN1 CENPF MED1 KLHL20 ZMYM5	1.22e-05	190	92	7	7070_UP
Drug	2-propylpentanoic acid; Up 200; 1000uM; MCF7; HG-U133A	CORO1A BIN1 MPZL1 COBL WRAP53 ASF1A TBL1X	1.30e-05	192	92	7	23_UP
Drug	Sulfamethizole [144-82-1]; Down 200; 14.8uM; MCF7; HT_HG-U133A	CORO1A PTPRA SLF2 TNRC6B NKTR KDM6A TBL1X	1.39e-05	194	92	7	6272_DN
Drug	Metolazone [17560-51-9]; Down 200; 11uM; PC3; HG-U133A	PTPRA WWP1 PPP2R3C MAP3K7 PICALM ASF1A KLHL20	1.44e-05	195	92	7	1932_DN
Drug	Amyleine hydrochloride [532-59-2]; Down 200; 14.8uM; PC3; HG-U133A	GCFC2 WDR5B WWP1 NUP42 PICALM KLHL20 DMXL1	1.49e-05	196	92	7	1909_DN
Drug	minocycline; Down 200; 10.5uM; MCF7; HT_HG-U133A_EA	SETD2 GCFC2 NRCAM ARFGAP1 NKTR RUBCN KLHL20	1.59e-05	198	92	7	1135_DN
Disease	inherited metabolic disorder (is_implicated_in)	TBX19 SUOX BCHE	1.22e-05	15	90	3	DOID:655 (is_implicated_in)
Disease	Usher syndrome type 2	MYO7A USH2A	2.75e-05	3	90	2	C0339534
Disease	Usher syndrome (is_implicated_in)	MYO7A USH2A	5.50e-05	4	90	2	DOID:0050439 (is_implicated_in)
Disease	zinc transporter 3 measurement	PIKFYVE BCHE	9.15e-05	5	90	2	EFO_0803287
Disease	serine/threonine-protein kinase Chk1 measurement	PIKFYVE BCHE	9.15e-05	5	90	2	EFO_0021965
Disease	e3 ubiquitin-protein ligase RNF43 measurement	APBB1 BCHE	9.15e-05	5	90	2	EFO_0021886
Disease	Usher Syndrome, Type II	MYO7A USH2A	9.15e-05	5	90	2	C1568249
Disease	dietary heme iron intake measurement, type 2 diabetes mellitus	TNRC6A SVEP1	1.37e-04	6	90	2	EFO_0008355, MONDO_0005148
Disease	pre-mRNA-processing factor 6 measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0802894
Disease	thymidine kinase, cytosolic measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0020773
Disease	o-acetyl-ADP-ribose deacetylase MACROD1 measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0802827
Disease	ribosome biogenesis protein TSR3 homolog measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0803025
Disease	CCAAT/enhancer-binding protein beta measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0021905
Disease	leucine-rich repeat and fibronectin type III domain-containing protein 1 measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0802689
Disease	leucine-rich repeat-containing protein 74A measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0801763
Disease	secreted frizzled-related protein 2 measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0802039
Disease	DNA-binding protein SATB2 measurement	PIKFYVE BCHE	1.37e-04	6	90	2	EFO_0802484
Disease	Growth Disorders	CYP1A2 LTBP3 RAI1	1.82e-04	36	90	3	C0018273
Disease	myotubularin-related protein 1 measurement	PIKFYVE BCHE	1.91e-04	7	90	2	EFO_0802773
Disease	RNA polymerase II elongation factor ELL measurement	PIKFYVE BCHE	1.91e-04	7	90	2	EFO_0802028
Disease	growth factor receptor-bound protein 7 measurement	PIKFYVE BCHE	2.55e-04	8	90	2	EFO_0801659
Disease	tumor necrosis factor receptor superfamily member 19L measurement	PIKFYVE BCHE	2.55e-04	8	90	2	EFO_0008309
Disease	Mental deterioration	BIN1 PICALM	3.27e-04	9	90	2	C0234985
Disease	cytochrome c oxidase subunit 4 isoform 2, mitochondrial measurement	PIKFYVE BCHE	3.27e-04	9	90	2	EFO_0801514
Disease	Mild cognitive disorder	BIN1 PICALM	3.27e-04	9	90	2	C1270972
Disease	transcription factor IIIb 90 kda subunit measurement	PIKFYVE BCHE	4.07e-04	10	90	2	EFO_0020778
Disease	DNA-directed RNA polymerases I and III subunit RPAC1 measurement	PIKFYVE BCHE	4.07e-04	10	90	2	EFO_0801535
Disease	OCIA domain-containing protein 1 measurement	PIKFYVE BCHE	4.07e-04	10	90	2	EFO_0008252
Disease	cancer antigen 125 measurement	MSLNL MUC16	4.07e-04	10	90	2	EFO_0010603
Disease	cytochrome p450 3a4 measurement	PIKFYVE BCHE	4.97e-04	11	90	2	EFO_0020303
Disease	guanylate-binding protein 6 measurement	PIKFYVE BCHE	4.97e-04	11	90	2	EFO_0801662
Disease	T-cell surface glycoprotein CD3 epsilon chain measurement	PIKFYVE BCHE	7.02e-04	13	90	2	EFO_0802114
Disease	Impaired cognition	BIN1 PICALM	8.17e-04	14	90	2	C0338656
Disease	malignant pleural mesothelioma (is_marker_for)	SETD2 KDM6A	8.17e-04	14	90	2	DOID:7474 (is_marker_for)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 SETD2 BCHE KDM6A	1.11e-03	148	90	4	C0279702
Disease	Alzheimer disease, psychotic symptoms	BIN1 PICALM	1.21e-03	17	90	2	EFO_0005940, MONDO_0004975
Disease	Carcinoma of bladder	KDM6A EPHA4	1.36e-03	18	90	2	C0699885
Disease	alcohol consumption measurement	CYP1A2 TNRC6A ANKS1B PPP1R13B COBL MED1 WRAP53 PKD1L3 MAP3K7 CIT EPHA4	1.39e-03	1242	90	11	EFO_0007878
Disease	esophagus squamous cell carcinoma (is_marker_for)	WRAP53 MMP14 KDM6A	1.52e-03	74	90	3	DOID:3748 (is_marker_for)
Disease	Drug toxicity	CYP1A2 BCHE HOMER1	2.19e-03	84	90	3	C0013221
Disease	Adverse reaction to drug	CYP1A2 BCHE HOMER1	2.19e-03	84	90	3	C0041755
Disease	Autism Spectrum Disorders	USH2A RAI1 TBL1X	2.26e-03	85	90	3	C1510586
Disease	alcohol use disorder (implicated_via_orthology)	MAP4K3 KDM6A HOMER2 HOMER1	3.04e-03	195	90	4	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TQNNSTSWPVFKSTE	BCHE	511	P06276
SSAWLQPSASGTSFQ	C2orf78	76	A6NCI8
SASKGWSTSENSLNV	ASF1A	181	Q9Y294
SKNDQWESEDSGSSP	C8orf34	296	Q49A92
QSFWETFGSAEPTKT	ARFGAP1	326	Q8N6T3
GSSPQEESQLTWTGF	APBB1	291	O00213
SNPTSASDDSNGLEW	AP1AR	246	Q63HQ0
SQTTWDSGFCAVNPK	CORO1A	31	P31146
GNLAQEPTDWTTSNT	CD177	221	Q8N6Q3
TGEKNTDDWESSPNT	DNHD1	1401	Q96M86
DVNGSKWTVTTFSTT	LVRN	286	Q6Q4G3
EKQSNSTLSFDWSQP	DMXL1	1941	Q9Y485
SNFDEPEKNSWVSSS	CIT	386	O14578
DGNWPTLKQNSSSSV	PPP1R13B	386	Q96KQ4
SASPQSSSFKVWDLS	NWD1	1186	Q149M9
GSAQSSSFSPEAWLQ	MMP14	26	P50281
TVGTESKVQSWFESS	RAI1	931	Q7Z5J4
SGQTSPRKQEAESWS	RABGEF1	386	Q9UJ41
QSLTFSTDSGPVWAA	CYP1A2	121	P05177
SKESQETNWFSAPSA	PPP2R3C	261	Q969Q6
SKGNSERTPSFTSEW	ANKS1B	766	Q7Z6G8
QGRSSSEATTFWKPS	MUC16	1596	Q8WXI7
TVNPNSTSSWFTESD	MAP4K3	756	Q8IVH8
STSSWFTESDTPQTN	MAP4K3	761	Q8IVH8
KSVQLSWTPGDDNNS	NRCAM	661	Q92823
EGSTKAWDTLTSPNN	LATS2	1016	Q9NRM7
TFTKTSQKFGQWADS	HOMER2	66	Q9NSB8
SATKQTSGATTEADW	FAM91A1	706	Q658Y4
SSAEEPWKNQLSNST	KDM6A	626	O15550
ETSVNLEWSSPQNTG	EPHA4	341	P54764
TSDSQPSDWIQKTAT	LRRC31	41	Q6UY01
WTPDDSTDTNGSDNS	MAP3K7	481	O43318
TNDAQASTSGSLWAP	MSLNL	626	Q96KJ4
SVSWSFQPEGADTTV	MPZL1	71	O95297
SNQSSFNFSSPESWV	HELZ	1791	P42694
FNFSSPESWVNTTSS	HELZ	1796	P42694
TFTKTSQKFGQWADS	HOMER1	66	Q86YM7
SQNSGAPVSDWSSDE	PLEKHH2	276	Q8IVE3
FNSRSENKTSSWTPE	LRRIQ1	1511	Q96JM4
TKTQGSSTSWFGSNQ	ARHGAP12	501	Q8IWW6
SSTSWFGSNQSKPEF	ARHGAP12	506	Q8IWW6
SSFSKSTPWGGSRDQ	NUP42	61	O15504
SLGSWINSSPDSSEN	KIF19	746	Q2TAC6
TTAPNWASQEGTSKQ	MAML2	961	Q8IZL2
QSWKTPGSLQAEDSN	PRICKLE4	321	Q2TBC4
GNWSNPEKTESSVYS	MALRD1	2121	Q5VYJ5
TDWSDDESNNPFSST	PACSIN2	396	Q9UNF0
TQWNSAEEGLPTNST	PIKFYVE	1691	Q9Y2I7
DPKTNQWSSDVAPTS	KLHL20	386	Q9Y2M5
TNSSDDWTISGIPAN	BOC	516	Q9BWV1
SGAQQSSTFVGWSSP	C2CD3	2181	Q4AC94
SSTFVGWSSPQTDQN	C2CD3	2186	Q4AC94
QASSSVFSWQQEKTP	CENPF	211	P49454
TSTSGNFSVDEKTQW	GCFC2	386	P16383
ADFSSTWPTSTNEKP	ITSN1	851	Q15811
SVFSTDGNETDSIWP	COBL	1071	O75128
CPTSQSESNSFWDTS	LTBP3	1186	Q9NS15
STIDWEGTSFSNSPA	GEN1	586	Q17RS7
FNLDTFTWSKLSPSG	KLHDC4	211	Q8TBB5
SAAEGTFAVSWPSQT	BIN1	436	O00499
NFSSEWSVGQVSTNT	DUOXA1	71	Q1HG43
SWVSSQNDSPGDASE	RUBCN	306	Q92622
DNKWTPSFSSITSAN	MED1	281	Q15648
WEGNSSTAATTPETF	PTPRA	121	P18433
GSTASEWISFTTQKE	USH2A	4916	O75445
TSSTSPGKWSQFFNP	SLC29A2	316	Q14542
FLSGSWSEFSTQPEN	WRAP53	156	Q9BUR4
WSSSEQESVFQSPES	PRUNE2	671	Q8WUY3
NGPTESTFSTSWKGD	NHSL2	381	Q5HYW2
STNTSLPDDNGAWKS	NKTR	936	P30414
SWPQKTSSEQAATTA	PKD1L3	1706	Q7Z443
PTSSSDTQKEGTAWR	PPARGC1B	166	Q86YN6
FKVNSSSAGPWANSS	SIGLEC5	381	O15389
TSATNTTVNNGSPEW	SLCO6A1	296	Q86UG4
NDSPTLQSNEWTDSF	TAOK3	236	Q9H2K8
SSDSWEPTSAGSKQN	SLF2	316	Q8IX21
WENTKESPATHSSNF	SVEP1	2661	Q4LDE5
ASQVASTWGDPFSAT	PICALM	411	Q13492
PSNKDVTSLDWNTNG	TBL1X	286	O60907
PDASFGKQWSSSSRS	PITPNM1	301	O00562
SVKFSPNGEWLASSS	WDR5B	46	Q86VZ2
TSSSTDQPKADLWQN	TCEANC	186	Q8N8B7
SSDFEDVPNKSWQQT	SETD2	1206	Q9BYW2
KFTPNGSSFSISWQS	ZNF704	321	Q6ZNC4
DSWISQSASFPSNQK	ZMYM5	196	Q9UJ78
SSSFHSPDSTIWKGQ	TNK1	411	Q13470
PSLTFSGDNSSTQGW	SUOX	41	P51687
LTDSQSWTESSINPG	ZDHHC2	336	Q9UIJ5
SSSSSNPKWDEQLTV	WWP1	56	Q9H0M0
SSSNNLQVFSGPDSW	TBX19	311	O60806
NWATTPSSQKKDTSN	TIAL1	81	Q01085
NSSGWDESSKPTPSQ	TNRC6A	906	Q8NDV7
TKNSNWESSASKPVS	TNRC6B	756	Q9UPQ9
GEPTTFQSWPSSKDT	MUC12	416	Q9UKN1
QGESTTFHSWPSSKD	MUC12	771	Q9UKN1
LQEESTTFQSWPSSS	MUC12	1576	Q9UKN1
QGESTTFQSWPSSKD	MUC12	1826	Q9UKN1
AGLQEESTTFQSWPS	MUC12	3131	Q9UKN1
TRQGESTTFQSWPNS	MUC12	3381	Q9UKN1
LQEESTTFQSWPSSS	MUC12	4216	Q9UKN1
QGESTTFQSWPNSKD	MUC12	4466	Q9UKN1
THPFTKISNWSSGNT	MYO7A	2151	Q13402
LWGDFSTASSSVPNQ	NECAP1	251	Q8NC96