Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnegative regulation of tolerance induction

PDCD1 CD86

8.04e-062592GO:0002644
DomainSAPAP

DLGAP2 DLGAP1

1.01e-045602IPR005026
DomainGKAP

DLGAP2 DLGAP1

1.01e-045602PF03359
DomainDisulphide_isomerase

PDIA4 PDIA5

2.81e-048602IPR005788
DomainThioredoxin

PDIA4 PDIA5

7.74e-0413602IPR005746
DomainThioredoxin_CS

PDIA4 PDIA5

1.34e-0317602IPR017937
DomainRasGEFN

RALGDS RASGRP2

1.86e-0320602SM00229
DomainRasGEF_N

RALGDS RASGRP2

2.05e-0321602PF00618
DomainRas-like_Gua-exchang_fac_N

RALGDS RASGRP2

2.25e-0322602IPR000651
DomainRASGEF_NTER

RALGDS RASGRP2

2.25e-0322602PS50212
DomainTHIOREDOXIN_1

PDIA4 PDIA5

2.90e-0325602PS00194
DomainRASGEF

RALGDS RASGRP2

3.14e-0326602PS00720
DomainRASGEF_CAT

RALGDS RASGRP2

3.90e-0329602PS50009
DomainRasGEF

RALGDS RASGRP2

4.17e-0330602PF00617
Domain-

RALGDS RASGRP2

4.17e-03306021.10.840.10
DomainRas_GEF_dom

RALGDS RASGRP2

4.17e-0330602IPR023578
DomainRASGEF_cat_dom

RALGDS RASGRP2

4.17e-0330602IPR001895
DomainRasGEF

RALGDS RASGRP2

4.17e-0330602SM00147
DomainThioredoxin

PDIA4 PDIA5

4.44e-0331602PF00085
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

STK36 MRPL21 EP400 HPS6 KBTBD11 PDIA5 TBC1D25 REV3L SPPL2B CNTROB IL4R SMG6 PPP1R16A

5.00e-081105611335748872
Pubmed

PD-L1 induces macrophage polarization toward the M2 phenotype via Erk/Akt/mTOR.

PDCD1 CD86

9.07e-06361233771483
Pubmed

PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.

PDCD1 CD86

9.07e-06361238349740
Pubmed

High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p.

DLGAP2 KBTBD11

1.81e-0546129314494
Pubmed

Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.

PDCD1 CD86

1.81e-05461212847135
Pubmed

Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

GFI1B IL4R

1.81e-05461229650672
Pubmed

Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.

DLGAP2 KBTBD11

1.81e-05461214508709
Pubmed

Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.

DLGAP2 DLGAP1

3.02e-05561233347690
Pubmed

Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.

PDCD1 CD86

3.02e-05561222798683
Pubmed

Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse.

DLGAP2 DLGAP1

3.02e-05561215024750
Pubmed

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.

PDCD1 CD86

3.02e-05561211015443
Pubmed

Progress in targeting HIV-1 entry.

PDIA4 PDIA5

3.02e-05561216182193
Pubmed

Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1.

PDCD1 CD86

3.02e-05561219454657
Pubmed

Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.

PDCD1 CD86

3.02e-05561215905503
Pubmed

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo.

PDCD1 CD86

3.02e-05561221697455
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

FOXM1 FAF2 OSCAR SYTL1 SPPL2B

4.04e-0521761534048709
Pubmed

pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family.

PDIA4 PDIA5

4.52e-05661216677074
Pubmed

Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env.

PDIA4 PDIA5

4.52e-05661215644496
Pubmed

Snapshot of the interaction between HIV envelope glycoprotein 120 and protein disulfide isomerase.

PDIA4 PDIA5

6.32e-05761220458450
Pubmed

Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry.

PDIA4 PDIA5

6.32e-05761212218051
Pubmed

Stability of a receptor-binding active human immunodeficiency virus type 1 recombinant gp140 trimer conferred by intermonomer disulfide bonding of the V3 loop: differential effects of protein disulfide isomerase on CD4 and coreceptor binding.

PDIA4 PDIA5

6.32e-05761217301129
Pubmed

Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection.

PDIA4 PDIA5

6.32e-05761223206338
Pubmed

SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.

DLGAP2 DLGAP1

6.32e-0576129115257
Pubmed

Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.

DLGAP2 DLGAP1

6.32e-05761210527873
Pubmed

DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.

DLGAP2 DLGAP1

6.32e-0576129286858
Pubmed

Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion.

PDIA4 PDIA5

8.42e-05861212218052
Pubmed

Proteins of the PDI family: unpredicted non-ER locations and functions.

PDIA4 PDIA5

8.42e-05861212384992
Pubmed

Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.

DLGAP2 DLGAP1

8.42e-05861219640847
Pubmed

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

PDCD1 CD86

8.42e-05861222544394
Pubmed

PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.

PDCD1 CD86

8.42e-05861220066438
Pubmed

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.

PDIA4 PDIA5

8.42e-05861222230366
Pubmed

Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.

HPS6 MYO15A

8.42e-05861215702992
Pubmed

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

PDCD1 IL4R

1.08e-04961228747424
Pubmed

Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.

DLGAP1 IL4R

1.08e-04961221070662
Pubmed

Global landscape of HIV-human protein complexes.

PDIA4 ABCB10 RTN4 PDIA5 AFF4 SMG6

1.50e-0445761622190034
Pubmed

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

PDCD1 RC3H1

1.65e-041161223583643
Pubmed

Mammalian E4 is required for cardiac development and maintenance of the nervous system.

PDIA4 NPPA

1.97e-041261216314518
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

HMBOX1 INTS6 SHC2 KIAA1217 SAMD4B PDIA5 SYTL1 SPPL2B AFF4 SMG6

2.47e-041489611028611215
Pubmed

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.

SLC18A3 NLGN1

3.13e-041561218227507
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RALGDS EP400 RTN4 KBTBD11 CHAMP1 SMG6

3.29e-0452961614621295
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

HMBOX1 RALGDS INTS6 KIAA1217 SPPL2B SMG6

3.53e-0453661615840001
Pubmed

The human protein disulfide isomerase gene family.

PDIA4 PDIA5

3.57e-041661223245351
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

HMBOX1 RALGDS INTS6 KIAA1217 SPPL2B SMG6

3.60e-0453861610512203
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

EP400 REV3L CHAMP1 AFF4

6.34e-0422261437071664
Pubmed

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.

RALGDS PDCD1 CD86 RASGRP2

6.89e-0422761426410627
Pubmed

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

ARRDC1-AS1 CNTROB AFF4 RASGRP2

7.24e-0423061429513927
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

EP400 NLGN1 SPPL2B

8.01e-0410361310819331
Pubmed

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

FAF2 EP400 GARIN5A DNM2 SMG6

8.47e-0441961528700943
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

DLGAP2 STK36 MAGEL2 FAF2 EP400

9.51e-0443061535044719
Pubmed

Nerve growth factor signaling, neuroprotection, and neural repair.

RALGDS SHC2

9.57e-042661211520933
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

DLGAP2 DLGAP1 DNM2

9.95e-0411161322558309
Pubmed

Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.

PDIA4 EP400

1.03e-032761221320693
Pubmed

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.

RC3H1 CNTROB

1.03e-032761235709258
Pubmed

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.

NLGN1 DNM2

1.11e-032861224448406
Pubmed

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

PDIA4 NPPA

1.11e-032861225332179
Pubmed

Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.

DLGAP2 NLGN1

1.36e-033161219736351
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

DLGAP2 DLGAP1 KBTBD11 NLGN1

1.52e-0328161428706196
Pubmed

The DNA sequence and biology of human chromosome 19.

FCGBP SHC2 SPPL2B DNM2

1.58e-0328461415057824
Pubmed

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

DLGAP2 DLGAP1 KIAA1217

1.60e-0313161328634551
Pubmed

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

PDZD7 SNTB1

1.64e-033461230726710
Cytoband19q13.33

GARIN5A MAMSTR TPRX1

3.91e-0410661319q13.33
GeneFamilyProtein disulfide isomerases

PDIA4 PDIA5

9.28e-0421392692
ToppCellSevere-B_memory-6|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CD86 GPSM3 SYTL1 SCIMP RASGRP2

4.43e-06177615c4c3511782d5febd0c8b369eebe9355ad3c3bcf2
ToppCellproximal-3-Hematologic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD86 OSCAR GPSM3 SCIMP RASGRP2

7.83e-06199615dff0ca657bfb42083000e3d0125b54480b034a93
ToppCellproximal-Hematologic|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD86 OSCAR GPSM3 SCIMP RASGRP2

7.83e-06199615183e388ac837585c50fed1189496167c9e61511e
ToppCell21|World / Age, Tissue, Lineage and Cell class

GFI1B FAM178B GPSM3 SYTL1 RASGRP2

7.83e-061996158c6517243168de4134e06dbe16ca89b1c2a73179
ToppCellLA-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

PDCD1 NPPA B3GNT3 SYTL1

1.82e-05114614ca69dddbdc02fa5718c56362649cd4b9b54f94ce
ToppCellBronchial-10x5prime-Hematologic-Erythrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FOXM1 STRADB NPPA FAM178B

2.70e-0512661465c7c0e4cfb5ac58d80b4034d42e9f662116e0d3
ToppCellBronchial-10x5prime-Hematologic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FOXM1 STRADB NPPA FAM178B

2.70e-05126614b6482ef18e6d9e12ba4810ce7845f9f991cb95bc
ToppCellBronchial-10x5prime-Hematologic-Erythrocyte-Erythrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FOXM1 STRADB NPPA FAM178B

2.70e-0512661412f3d0f60db462f2a9799b3a06005bc871670760
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STRADB CD86 PEAK3 SCIMP

4.56e-051446147c471e332f87d60f4dbed01f3e66bf39995218d0
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDCD1 CD86 GPSM3 PSD4

6.54e-05158614b1b1e50ddd231dcd10cc8e6bb68b2a5e0bb1450a
ToppCellPaneth_cell|World / shred on cell type and cluster

DLGAP1 PDCD1 SHC2 CD86

6.86e-05160614d787b7cdb8c3f677ac9c4934a5df9cc194df3987
ToppCellC_07|World / shred on cell type and cluster

DLGAP1 PDCD1 SHC2 CD86

6.86e-05160614b7c5a8a1c85da92e1945721b6887b32fad7b76b8
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-mature_NK_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDCD1 GPSM3 SYTL1 PSD4

7.55e-0516461422f37c39fdce2cf6dc72c6db619537d4b0234839
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXM1 SHC2 NLGN1 CNTROB

7.92e-0516661449103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCelldroplet-Kidney-nan-21m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 PDCD1 CD86 SCIMP

8.68e-05170614510625bd725d3590cffcd7acd1d42219f6eb1139
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD86 OSCAR SCIMP RASGRP2

9.50e-05174614eaaf17a06efc09ed4752b449827b1f0f424d3dad
ToppCell18-Distal-RBC-RBC|Distal / Age, Tissue, Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

9.71e-051756147130b816e0c02309c161d8e9ad7cb4bc2469e251
ToppCell18-Distal-RBC|Distal / Age, Tissue, Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

9.71e-05175614cc476b4244442418b8f21721a82a36209b556b36
ToppCelldroplet-Marrow-nan-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GFI1B STRADB ABCB10 SPPL2B

9.92e-05176614f92063b72ebfeb9b192281dc63d6bf2759c78554
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FCGBP HPS6 KBTBD11 TBC1D25

1.01e-041776148dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FCGBP HPS6 KBTBD11 TBC1D25

1.01e-04177614767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCell10x5'-Liver-Lymphocytic_B_plasma-Plasmablasts|Liver / Manually curated celltypes from each tissue

FOXM1 PDIA4 PDIA5 MESP2

1.01e-041776141d88ae316d65ca5fdc736c9da93885b6b40c32bb
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FCGBP HPS6 KBTBD11 TBC1D25

1.01e-041776145ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCellE18.5-Endothelial-Endothelial_lymphatic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FCGBP HPS6 KBTBD11 TBC1D25

1.01e-04177614ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Red_blood_cells-RBC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GFI1B STRADB ABCB10 FAM178B

1.11e-04181614f4cd6dba4c04c5cb550f44468eb29c07238fbda4
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Red_blood_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GFI1B STRADB ABCB10 FAM178B

1.11e-04181614c7f5d0e5aa2ca6a409957713637e1b37a73ceb60
ToppCell18-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

GFI1B FAM178B GPSM3 RASGRP2

1.13e-04182614cd0b9f0a25147ec3bc1e32d698511d1c3b33891f
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-hematologic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GFI1B STRADB ABCB10 FAM178B

1.15e-041836141db466cf757813322db1cdcc0bf1d91c062fd9de
ToppCellwk_08-11-Hematologic-Meg-ery|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GFI1B STRADB ABCB10 FAM178B

1.15e-041836147eecb8d80e31ca26c2e6ce43bf0f2c71be1643e4
ToppCellwk_15-18-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GFI1B STRADB ABCB10 FAM178B

1.18e-04184614238eba615b4e04967d44ac7858a6673bdd7f67e9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FCGBP CD86 IL4R DNM2

1.20e-0418561476fc5bbb71e42c0eb70474efcd3a71a7b2633f24
ToppCellwk_08-11-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GFI1B STRADB ABCB10 FAM178B

1.25e-04187614c0965293f08d3e49000871777a5b26d81a4af203
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD86 OSCAR GPSM3 SCIMP

1.28e-04188614c7c2cf1aa328e735073d6031e44b5dbd55beae6d
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

GPSM3 SCIMP IL4R RASGRP2

1.28e-04188614064a66cbca5648371d6360cfcb3965845a81c65f
ToppCellwk_08-11-Hematologic-Myeloid-DC2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CD86 OSCAR GPSM3 SCIMP

1.33e-04190614902afe2121593ae08d083c2cea2d1ba9f848574a
ToppCell390C-Myeloid-Macrophage|390C / Donor, Lineage, Cell class and subclass (all cells)

FCGBP CD86 OSCAR SCIMP

1.33e-04190614f933d971f092c4e56e9f670a9205b688c8b1ca28
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Follicular_B_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

GPSM3 SCIMP IL4R RASGRP2

1.36e-0419161406edf2e9b50ea20060648d41fa42ee16086fdf42
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-cDC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD86 OSCAR GPSM3 SCIMP

1.36e-04191614a898153490fb9e8c4331c5dce63dbfb5185bccf2
ToppCellkidney_cells-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.39e-04192614ae7513fde6e33a1908c2777cdb1d1e4ead1bcb2f
ToppCell10x3'2.3-week_12-13-Hematopoietic-erythroid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

GFI1B STRADB ABCB10 FAM178B

1.39e-041926146ace9a34ed264583042156ed61c2cb3504a331d2
ToppCell3'-Adult-LargeIntestine-Hematopoietic-B_cells-Naive_B|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPSM3 SCIMP IL4R RASGRP2

1.41e-041936148d88f3b0d08f9dbae26ee122dbd43f06e2cc3f67
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

HMBOX1 DLGAP1 SNTB1 AFF4

1.41e-04193614e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellCOVID-19-kidney-Glomerular_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

HMBOX1 SHC2 KIAA1217 IL4R

1.44e-04194614660535b492445063d965095a50e1e299ce04c50a
ToppCellMonocytes-HP_01|World / lung cells shred on cell class, cell subclass, sample id

CD86 GPSM3 SCIMP RASGRP2

1.44e-04194614fa6a2794baa6be6298f415330ff51b26a5402571
ToppCellwk_20-22-Hematologic-Myeloid-S100A12-lo_cla._mono.|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FCGBP CD86 OSCAR SCIMP

1.47e-0419561466273af9882f829b6fc0e20f03f3412294d37c26
ToppCell10x3'2.3-week_14-16-Hematopoietic-erythroid|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GFI1B STRADB ABCB10 FAM178B

1.47e-04195614b24f6fe71fbcffe7ff1fd1374455c378837d6313
ToppCell15-Trachea-RBC-RBC|Trachea / Age, Tissue, Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

1.50e-04196614511bfc06c34d5add2ae561cca463d1e4e2d43e20
ToppCellVE-granulo1-|VE / Condition, Cell_class and T cell subcluster

DLGAP2 CD86 OSCAR SCIMP

1.50e-04196614ab3f2ce294c7e503d86254a195be0cf500a2c5e4
ToppCell10x5'v1-week_12-13-Hematopoietic-erythroid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

GFI1B STRADB ABCB10 FAM178B

1.50e-041966140aae78e73d53416d857bdf21f595a0a0a0ba7944
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-neutrophil-promyelocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PDIA4 NDUFB11 KBTBD11 RASGRP2

1.50e-041966148ff0135e108764a3527acc00a994ced342e1cad1
ToppCellVE-granulo1|VE / Condition, Cell_class and T cell subcluster

DLGAP2 CD86 OSCAR SCIMP

1.50e-041966146dbd3acb30173d7f0b7bca0a82f435f00ca85835
ToppCellwk_15-18-Hematologic-Myeloid-DC3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CD86 OSCAR GPSM3 SCIMP

1.50e-0419661420808c2ce010e4fcda092ecce94487f0afff733b
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD86 OSCAR GPSM3 SCIMP

1.50e-04196614f667430a61bc962e4d033818a05348bf40762041
ToppCell10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic_early|bone_marrow / Manually curated celltypes from each tissue

GFI1B STRADB ABCB10 FAM178B

1.50e-04196614507254c4c00e535fe01851431b5b74a5f15d9592
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

FOXM1 ARMC5 PDZD7 CNTROB

1.50e-0419661436ed1918f70b6f5760bb088b15ce422998055cc7
ToppCell15-Trachea-RBC|Trachea / Age, Tissue, Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

1.50e-04196614bf2670e5ae996a19987bc70aa5a37d133db789eb
ToppCellkidney_cells-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.50e-0419661463b841457d12fb9dd25630e3c348d3ef53463f86
ToppCellerythropoietic|World / Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

1.53e-04197614a52546cebc222050c970e04cec97e4f48ab8fe10
ToppCell10x5'v1-week_14-16-Myeloid_monocytic-monocyte-MOP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PDIA4 NDUFB11 KBTBD11 RASGRP2

1.53e-041976144e68a98bc7e5db7f20e865a0ca21e5a43b3cbb8f
ToppCell10x3'2.3-week_14-16-Hematopoietic|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GFI1B STRADB ABCB10 FAM178B

1.53e-0419761497a837477043902f0f5c9db850a3bfa001ea74d1
ToppCellkidney_cells-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.53e-0419761449511ea2330a516456007e73bc3195334433011c
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD86 GPSM3 SCIMP RASGRP2

1.53e-04197614b4f6501c266328439cba4f174e594a6a04a252a1
ToppCelldistal-Hematologic-Nonclassical_Monocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GFI1B CD86 GPSM3 SCIMP

1.53e-04197614e817c1a8549e403e723b1b6c73cdb04f1179909d
ToppCell21-Trachea-RBC|Trachea / Age, Tissue, Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

1.53e-041976149f8eb6305ade0654bbcd8f19963be0b64af083de
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD86 GPSM3 SCIMP RASGRP2

1.53e-04197614c6e977adb1248957d31300312310e08238b64236
ToppCellerythropoietic-Polychromatic_Erythroblast|World / Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

1.53e-04197614604fcbf47f073c2af344e1b16b615a78ef838dc9
ToppCell21-Trachea-RBC-RBC|Trachea / Age, Tissue, Lineage and Cell class

GFI1B STRADB ABCB10 FAM178B

1.53e-041976144710b55806a618076a954190f519e49c55d300d3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.56e-04198614d681aff379720261d85f9c1c6030932c5046960e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.56e-041986148fe5e6b563bee2179b0f17d6591870d7dd76e891
ToppCellVE-mono1-|VE / Condition, Cell_class and T cell subcluster

FCGBP CD86 OSCAR SCIMP

1.56e-041986142959d6e4992c36040ec9637f5a2daed02b35cf30
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.56e-04198614d3e19705f92c665b5b319569000f22913135f331
ToppCellVE-mono1|VE / Condition, Cell_class and T cell subcluster

FCGBP CD86 OSCAR SCIMP

1.56e-04198614c742871b8ec4720b1848991551c7c1f4000ebd85
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.56e-04198614c00dbe61dc25602f19bd42a760646680002961ca
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.59e-04199614e48b1fde8d3b3abd3c7362c27dc74d26e7d33078
ToppCellkidney_cells-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.59e-041996140a9783808528bc4c6d797d849a9177330c8fb867
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD86 OSCAR GPSM3 SCIMP

1.59e-04199614bdb865c0f4a2af7ad4b677b7d9a1e9ae2b7ec5b5
ToppCell10x3'2.3-week_12-13-Myeloid_monocytic-monocyte-CD14_monocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CD86 OSCAR GPSM3 SCIMP

1.62e-042006144984d27b3768be3b8fca3391cd2b7ab1749e2913
ToppCell11.5-Distal-Immune|Distal / Age, Tissue, Lineage and Cell class

CD86 OSCAR GPSM3 SCIMP

1.62e-04200614c9ed06ae7a8f5a88578c8269d762d8739ae79c7f
ToppCell10x5'v1-week_17-19-Myeloid_monocytic-monocyte-CD14_monocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CD86 OSCAR GPSM3 SCIMP

1.62e-0420061407197f95282ee607db17b92fea1376051e65fc50
Diseasepyruvate measurement

GFI1B DLGAP2 KIAA1217 ARMC5 TPRX1 PDIA5

1.45e-05268586EFO_0010117
Diseasepulmonary tuberculosis (is_marker_for)

PDCD1 CD86 IL4R

4.91e-0536583DOID:2957 (is_marker_for)
Diseaseaplastic anemia (is_marker_for)

GFI1B CD86

1.35e-049582DOID:12449 (is_marker_for)
Diseasemultiple sclerosis (is_implicated_in)

PDCD1 CD86 IL4R

4.07e-0473583DOID:2377 (is_implicated_in)
DiseaseArthrogryposis

MAGEL2 SLC18A3

7.78e-0421582C0003886
Diseasetissue factor measurement

GFI1B MAMSTR

7.78e-0421582EFO_0010623
Diseasebilirubin measurement

NEU2 MAMSTR NLGN1 REV3L SMG6

1.76e-03442585EFO_0004570
Diseaseacute lymphoblastic leukemia (is_marker_for)

GFI1B CD86

2.05e-0334582DOID:9952 (is_marker_for)
Diseasenasal disorder

MAMSTR IL4R

2.17e-0335582MONDO_0002436
Diseasesystemic lupus erythematosus (implicated_via_orthology)

PDCD1 RC3H1

3.26e-0343582DOID:9074 (implicated_via_orthology)
Diseasehereditary spastic paraplegia (implicated_via_orthology)

RTN4 DNM2

3.26e-0343582DOID:2476 (implicated_via_orthology)
Diseaseplatelet measurement

GFI1B RTN4 PDIA5 SMG6

3.44e-03315584EFO_0005036

Protein segments in the cluster

PeptideGeneStartEntry
PDSVPQGDPVWPPES

nan

136

Q6ZR03
PLPEVPPWTGEVSPA

NPPA

76

P01160
YPDTWNPPPTSLDLP

SMG6

1036

Q86US8
PLWTPPTPPQDDSDI

EP400

2246

Q96L91
AWPLRLLEPPSPAEP

ABCB10

6

Q9NRK6
DISPDWSPEQCPPEP

ARMC5

471

Q96C12
FDPSILPPPDPWIDS

DLGAP1

761

O14490
LPPPDPWIDSITEDP

DLGAP1

766

O14490
VDTSTLPPPDPWLEP

DLGAP2

836

Q9P1A6
LPPPDPWLEPAIDTV

DLGAP2

841

Q9P1A6
LEDPQPPPDHIPWIT

CD86

236

P42081
SPEPEPPPTNKWQLD

AFF4

461

Q9UHB7
ANIDPSPDAPPPTWE

RC3H1

361

Q5TC82
PESFWPDQNSPTLPP

INTS6

286

Q9UL03
PPQDEEGWPPPNSTT

GPSM3

16

Q9Y4H4
PVPWDPPPIDLQASL

MAGEL2

41

Q9UJ55
TSCTPPPRPPVLEEW

RASGRP2

396

Q7LDG7
APSWDVDMPPTQRPP

MYO15A

926

Q9UKN7
QEDEPLWPPALTPVP

GFI1B

21

Q5VTD9
EPRNPPVPWTAAPAT

MESP2

286

Q0VG99
NIWVPADPVSPPSLP

C9orf131

461

Q5VYM1
APIPIEDPEWRQTPP

HMBOX1

241

Q6NT76
DSPDRPWNPPTFSPA

PDCD1

26

Q15116
GWPLTPTPLDPHEPE

FHIP2B

581

Q86V87
DAAPVPAHWLPEPPT

PDZD7

981

Q9H5P4
PPTEPPEPDNPTWST

PEAK3

6

Q6ZS72
WPDLQEPPPPGTSSQ

GARIN5A

6

Q6IPT2
QPPEPPSPWSDIRNA

NLGN1

96

Q8N2Q7
TPVPPPVDDTWLQSA

DNM2

746

P50570
QTQDSWDPAPPPSDP

OSCAR

266

Q8IYS5
LNPRPPAPEAWSEPV

NEU2

311

Q9Y3R4
LSEPTTVPQPEPETW

IL4R

536

P24394
WEEVVPDSPCLPPPT

FCGBP

3821

Q9Y6R7
PEPRKPSPSESPEPW

CHAMP1

276

Q96JM3
PAIPEALAWPTPPTR

B3GNT3

41

Q9Y2A9
LEPAPAPVPSLQPSW

RALGDS

351

Q12967
PDPWISASDPPLAPA

MAMSTR

36

Q6ZN01
PIKVESPPLEEWPSP

FOXM1

476

Q08050
ENWNLNPEPSSPPSP

ARRDC1-AS1

61

Q9H2J1
PYEDILWDPSTPPPT

HPS6

756

Q86YV9
KRPPEPTTPWQEDPE

NDUFB11

46

Q9NX14
VPSWEEAPQVPRIPP

CNTROB

741

Q8N137
NPEAPPPPEPTWEEQ

PDIA5

381

Q14554
PPPASVSPQAEPVWT

RTN4

146

Q9NQC3
VSPQAEPVWTPPAPA

RTN4

151

Q9NQC3
TWLPLQPRVPPSPDD

SYTL1

381

Q8IYJ3
PVSEIGWETPPPESP

SNTB1

206

Q13884
PTRTPEVWEPTLPLP

SLC18A3

71

Q16572
EVWEPTLPLPTPANA

SLC18A3

76

Q16572
PPLPPRNWPSLEDSS

SCIMP

81

Q6UWF3
WSSLPPDPPEHEVEL

TBC1D25

431

Q3MII6
FPTDWSPPPVEFLNP

FAM178B

106

Q8IXR5
VLPCIPSEEWPNPPT

FAF2

411

Q96CS3
WATDPPEPTRQNVPP

PSD4

51

Q8NDX1
VWQQPPPTSPEPPED

PPP1R16A

371

Q96I34
AEEPASAWTPSPPPV

KIAA1217

1101

Q5T5P2
EVSQPDWTPPPEVTL

PDIA4

166

P13667
PSPEPRVWLEDPASP

KBTBD11

106

O94819
SPPSPEPDWTLISPQ

STK36

906

Q9NRP7
SLPAPAPLWPQSPDA

TPRX1

326

Q8N7U7
DSPVIPPWQQPISPD

REV3L

2121

O60673
PTSPQVPGEWPSPEE

SAMD4B

241

Q5PRF9
AAPLPLEDQWPSPPT

SHC2

456

P98077
EVPGPSAPWIDPSPQ

SPDYE4

31

A6NLX3
LSPQPPSEEPATSPW

SPPL2B

531

Q8TCT7
LSSPPWPEVVLPDPV

MRPL21

56

Q7Z2W9
PSISLPPVLPWTEPE

STRADB

391

Q9C0K7