Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	CEP350 KIFAP3 SPTBN2 SYNE2 UNC5C CTNNA3 OBSCN AFDN MICAL3 MPRIP MSN	6.87e-05	1099	50	11	GO:0008092
GeneOntologyMolecularFunction	actin binding	SPTBN2 SYNE2 CTNNA3 AFDN MICAL3 MPRIP MSN	1.79e-04	479	50	7	GO:0003779
GeneOntologyMolecularFunction	cadherin binding	SPTBN2 CTNNA3 OBSCN AFDN MPRIP	1.55e-03	339	50	5	GO:0045296
GeneOntologyMolecularFunction	actin filament binding	SPTBN2 CTNNA3 AFDN MPRIP	2.49e-03	227	50	4	GO:0051015
GeneOntologyBiologicalProcess	regulation of cell morphogenesis	FBXO31 ENPP2 AFDN PEAK3 SLC30A1 PLXNB2 MSN	6.83e-06	302	49	7	GO:0022604
Domain	CH	SPTBN2 SYNE2 MICAL3	7.02e-04	65	50	3	SM00033
Domain	CH	SPTBN2 SYNE2 MICAL3	8.71e-04	70	50	3	PF00307
Domain	-	SPTBN2 SYNE2 MICAL3	9.08e-04	71	50	3	1.10.418.10
Domain	CH	SPTBN2 SYNE2 MICAL3	9.84e-04	73	50	3	PS50021
Domain	CH-domain	SPTBN2 SYNE2 MICAL3	1.06e-03	75	50	3	IPR001715
Domain	Actinin_actin-bd_CS	SPTBN2 SYNE2	1.71e-03	23	50	2	IPR001589
Domain	Spectrin	SPTBN2 SYNE2	1.71e-03	23	50	2	PF00435
Domain	ACTININ_2	SPTBN2 SYNE2	1.71e-03	23	50	2	PS00020
Domain	ACTININ_1	SPTBN2 SYNE2	1.71e-03	23	50	2	PS00019
Domain	Spectrin_repeat	SPTBN2 SYNE2	2.72e-03	29	50	2	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN2 SYNE2	3.31e-03	32	50	2	IPR018159
Domain	SPEC	SPTBN2 SYNE2	3.31e-03	32	50	2	SM00150
Domain	-	ARHGEF40 SPTBN2 OBSCN MPRIP MSN	3.83e-03	391	50	5	2.30.29.30
Domain	PH_dom-like	ARHGEF40 SPTBN2 OBSCN MPRIP MSN	5.50e-03	426	50	5	IPR011993
Domain	PH	ARHGEF40 SPTBN2 OBSCN MPRIP	6.47e-03	278	50	4	SM00233
Domain	PH_DOMAIN	ARHGEF40 SPTBN2 OBSCN MPRIP	6.55e-03	279	50	4	PS50003
Domain	PH_domain	ARHGEF40 SPTBN2 OBSCN MPRIP	6.63e-03	280	50	4	IPR001849
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	SPTBN2 UNC5C SANBR ZKSCAN8 ATG9A HSD17B4 PLXNB2 CNTROB EMSY MEN1 MSN	8.00e-08	925	51	11	28986522
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	STXBP3 KRT222 UNC5C MICAL3 SLC30A1 PLXNB2 TRIP11 MPRIP	1.74e-07	421	51	8	36976175
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 ARHGEF40 WIZ NCAPD2 OBSCN MICAL3 ATG9A MAPKBP1 PLXNB2 CNTROB MPRIP	4.71e-07	1105	51	11	35748872
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	STXBP3 SPTBN2 AFDN ATG9A HSD17B4 SLC30A1 TRIP11	5.23e-06	467	51	7	30194290
Pubmed	Gene network analysis in a pediatric cohort identifies novel lung function genes.	CTNNA3 MICAL3 OCA2	5.88e-06	24	51	3	24023788
Pubmed	The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.	AFDN MEN1	6.32e-06	3	51	2	16239140
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	WIZ SPTBN2 SYNE2 AFDN TRIP11 EMSY SLC12A5 MPRIP MSN	9.87e-06	963	51	9	28671696
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP350 USP34 WIZ ENPP2 KRT222 SPTBN2 AFDN HSD17B4 TRIP11 MPRIP	1.47e-05	1285	51	10	35914814
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CEP350 WIZ STXBP3 SPTBN2 SYNE2 MICAL3 HSD17B4 SLC30A1 CNTROB	1.94e-05	1049	51	9	27880917
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CEP350 STXBP3 SPTBN2 AFDN MICAL3 HSD17B4 EMSY MEN1	3.17e-05	853	51	8	28718761
Pubmed	Linkage of isozyyme loci in the mouse: phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1).	OCA2 H6PD	4.41e-05	7	51	2	4397868
Pubmed	Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.	SPTBN2 TRIP11	9.42e-05	10	51	2	25605782
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CEP350 USP34 WIZ UNC5C AFDN SLC30A1 TRIP11	1.33e-04	777	51	7	35844135
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	AFDN MICAL3 MPRIP	1.33e-04	67	51	3	29254152
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	WIZ SPTBN2 NCAPD2 AFDN EMSY MPRIP	1.48e-04	549	51	6	38280479
Pubmed	Computational and experimental studies on human misshapen/NIK-related kinase MINK-1.	KIFAP3 SPTBN2	1.63e-04	13	51	2	15032605
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	ZKSCAN8 MICAL3 TRIP11 EMSY MSN	1.84e-04	360	51	5	33111431
Pubmed	Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.	ENPP2 MSN	1.90e-04	14	51	2	27641493
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	WIZ STXBP3 AFDN MSN	2.83e-04	215	51	4	35973513
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNE2 PLXNB2 MPRIP	2.89e-04	87	51	3	12465718
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	WIZ ACAD11 HSD17B4 EMSY	3.19e-04	222	51	4	37071664
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	CEP350 ACAD11 SYNE2 UNC5C IMP3 TRIP11	3.32e-04	638	51	6	31182584
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	NCAPD2 QPCT HSD17B4 MPRIP MEN1 MSN	3.58e-04	647	51	6	26618866
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	STXBP3 NCAPD2 OBSCN IREB2 MICAL3 PLXNB2 CNTROB MSN	3.63e-04	1215	51	8	15146197
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ARHGEF40 ACAD11 AFDN MICAL3 HSD17B4 MSN	3.67e-04	650	51	6	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 SPTBN2 SYNE2 NCAPD2 AFDN MSN	3.76e-04	653	51	6	22586326
Pubmed	Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.	ATG9A MSN	4.78e-04	22	51	2	34799561
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	ACAD11 HSD17B4	6.70e-04	26	51	2	30378028
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CEP350 SPTBN2 SYNE2 AFDN HSD17B4 PLXNB2 IMP3	7.03e-04	1024	51	7	24711643
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	ACAD11 HSD17B4	7.78e-04	28	51	2	22002062
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CEP350 ARHGEF40 ACAD11 SPTBN2 KBTBD8 IREB2 ALK MPRIP	8.04e-04	1371	51	8	36244648
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	ROGDI WIZ UNC5C ATG9A	8.15e-04	285	51	4	34369648
Pubmed	Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.	ENPP2 PEAK3	8.35e-04	29	51	2	21998595
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	USP34 ENPP2 SLC12A5	8.91e-04	128	51	3	30995482
Pubmed	Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.	UNC5C PLXNB2	8.93e-04	30	51	2	32562661
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPTBN2 SYNE2 UNC5C NCAPD2 SANBR HSD17B4 MEN1 MSN	1.11e-03	1442	51	8	35575683
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	USP34 UNC5C H6PD HSD17B4 SLC30A1 PLXNB2 TRIP11 MSN	1.16e-03	1451	51	8	30550785
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	WIZ EMSY MEN1	1.30e-03	146	51	3	23892456
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	SPTBN2 AFDN SLC30A1 TRIP11 MPRIP	1.41e-03	565	51	5	25468996
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	WIZ ACAD11 NCAPD2 AFDN IMP3 EMSY MPRIP MEN1	1.41e-03	1497	51	8	31527615
Interaction	EPHA2 interactions	STXBP3 KRT222 UNC5C AFDN MICAL3 SLC30A1 PLXNB2 TRIP11 ALK MPRIP	1.07e-05	719	51	10	int:EPHA2
Interaction	LTK interactions	HSD17B4 TRIP11 ALK MPRIP MSN	4.06e-05	152	51	5	int:LTK
Interaction	TOP3B interactions	USP34 ARHGEF40 WIZ SPTBN2 NCAPD2 OBSCN IREB2 MICAL3 ATG9A MAPKBP1 PLXNB2 CNTROB MPRIP	5.44e-05	1470	51	13	int:TOP3B
Interaction	NRAS interactions	STXBP3 SPTBN2 AFDN XPA ATG9A HSD17B4 SLC30A1 TRIP11 MSN	5.69e-05	699	51	9	int:NRAS
Interaction	APEX1 interactions	WIZ SPTBN2 UNC5C SANBR ZKSCAN8 ATG9A HSD17B4 PLXNB2 CNTROB EMSY MEN1 MSN	5.99e-05	1271	51	12	int:APEX1
Cytoband	Ensembl 112 genes in cytogenetic band chr2p15	USP34 SANBR	1.11e-03	44	51	2	chr2p15
Coexpression	PGF_UP.V1_UP	CEP350 STXBP3 SYNE2 IREB2 HSD17B4 TRIP11	1.84e-06	190	51	6	M2674
ToppCell	droplet-Marrow-nan-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 PIGL ZKSCAN8 SLC30A1 PLXNB2	1.66e-06	174	51	5	55cc8300489d11322724159ec7d0e1d32a702e91
Drug	Pilocarpine nitrate [148-72-1]; Down 200; 14.8uM; HL60; HT_HG-U133A	WIZ GPATCH3 BSPRY HEMK1 H6PD TRIP11	4.92e-06	196	51	6	2438_DN
Drug	Niridazole [61-57-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	USP34 GPATCH3 ENPP2 MAPKBP1 ALK EMSY	5.21e-06	198	51	6	5682_UP
Disease	vital capacity	USP34 PIGL ENPP2 SPTBN2 CTNNA3 MICAL3 MAPKBP1 TRIP11 MARCO	2.05e-04	1236	50	9	EFO_0004312
Disease	forced expiratory volume	ENPP2 SPTBN2 IREB2 MICAL3 PLXNB2 TRIP11 MARCO	3.50e-04	789	50	7	EFO_0004314
Disease	atrial fibrillation	USP34 SYNE2 CTNNA3 SANBR MPRIP	4.07e-04	371	50	5	EFO_0000275
Disease	maximal midexpiratory flow rate	MICAL3 OCA2	5.24e-04	20	50	2	EFO_0004313
Disease	cutaneous melanoma	SYNE2 OCA2 PLXNB2	1.15e-03	121	50	3	EFO_0000389
Disease	Papillary Renal Cell Carcinoma	SYNE2 UNC5C ALK	1.35e-03	128	50	3	C1306837
Disease	Renal Cell Carcinoma	SYNE2 UNC5C ALK	1.35e-03	128	50	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	SYNE2 UNC5C ALK	1.35e-03	128	50	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	SYNE2 UNC5C ALK	1.35e-03	128	50	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	SYNE2 UNC5C ALK	1.35e-03	128	50	3	C1266044

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDEERRKLADIIHHW	AFDN	6	P55196
SHWVEIHQEVVRLCR	ARHGEF40	671	Q8TER5
AHEVVAHWIAESRIA	ACAD11	666	Q709F0
LQHHEAIIEEAEIRW	CCDC113	126	Q9H0I3
DIHDFEIILHRVEWA	OCA2	666	Q04671
RWFERLQAIEHELHE	QPCT	266	Q16769
LHDIWPSREEVHRVE	IREB2	661	P48200
RDVHLALSEDHAWVV	MEN1	176	O00255
IQADVHWTHIREREE	MICAL3	1036	Q7RTP6
DLKTHNVHVEIEQRW	MPRIP	626	Q6WCQ1
VEWVLEEVAQRSHAV	HEMK1	141	Q9Y5R4
RGEEWERHEALHEDV	GPATCH3	296	Q96I76
REEWGRTLEDIFHEH	FBXO31	251	Q5XUX0
GERHALLEEENRVWH	PLXNB2	1576	O15031
KEARRQWHHLQVEIE	KRT222	56	Q8N1A0
VRAHEDAWHILVAKV	PEAK3	191	Q6ZS72
EAVTEEQAELRRWEH	EVC2	816	Q86UK5
DQWEERIQVWHEEHR	MSN	166	P26038
SIIRWFEHEQNEREV	KBTBD8	216	Q8NFY9
ELLWDVHSHVVRETT	OBSCN	6326	Q5VST9
WENHIHVLTEAVDDI	CTNNA3	486	Q9UI47
EERAHQSILTQRVHW	BSPRY	136	Q5W0U4
ISDEDWDIIHRVHLR	HSD17B4	111	P51659
AQAEPERHVWHRRES	ATG9A	721	Q7Z3C6
HILVQELHEEEAQWV	CEP350	3061	Q5VT06
TWVRVSHEHLLQRVD	MARCO	121	Q9UEW3
VHRDWRVHLALDVAN	GPR142	386	Q7Z601
VRVWDVAEHSQVAEL	MAPKBP1	116	O60336
WEVTDHNLHELRVLR	IMP3	21	Q9NV31
VVHVIASRRQDWSEH	EMSY	736	Q7Z589
DGLWNRHHVERVEII	H6PD	226	O95479
IEDIHLLVERRWHVA	ENPP2	441	Q13822
RVVEGWNRHEAERTE	CNTROB	241	Q8N137
IIDHELKRHELWQEE	KIFAP3	226	Q92845
EDHQTWRNFIELVRE	SLC12A5	806	Q9H2X9
EEEFRWLLHDEVHAV	ROGDI	16	Q9GZN7
VLKEQIEHLHRQWED	SYNE2	5886	Q8WXH0
QWDTEHVARVLLQHI	PIGL	121	Q9Y2B2
IQEEWVRHLQRHILE	WIZ	1611	O95785
RWEEVDISVHCDVHI	SANBR	186	Q6NSI8
DDLWVRIRHRHIAVV	STXBP3	286	O00186
IEEEIRVNRSVHEWA	ALK	801	Q9UM73
IRHLWNHSIIEEEFV	NCAPD2	181	Q15021
HQFHRDVEDEILWVT	SPTBN2	1491	O15020
RSSVWKRETIVHQHE	XPA	231	P23025
DVRRVWLSSVVDHFH	ZUP1	336	Q96AP4
VSRLESEVGHWRHIA	TRIP11	181	Q15643
EELHLHAENLSRRVW	USP34	1381	Q70CQ2
RNVEGVEEVHELHVW	SLC30A1	361	Q9Y6M5
NSEWVHQKDHIVDER	UNC5C	96	O95185
VTEEQRHIQEEHKWA	WDR87	1561	Q6ZQQ6
QHADVSLSDVEWIRH	WDR87	2516	Q6ZQQ6
SARVHGHRVLWEEVV	ZKSCAN8	141	Q15776