Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF717 ZNF737 ZNF479 ZNF208 KLF18 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	4.42e-16	1459	34	21	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF717 ZNF737 ZNF479 ZNF208 KLF18 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	8.25e-15	1244	34	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF717 ZNF737 ZNF479 ZNF208 KLF18 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	1.22e-14	1271	34	19	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF717 ZNF737 ZNF479 ZNF208 KLF18 ZNF716 ZNF680 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254	8.19e-14	1412	34	19	GO:0000981
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF717 ZNF208 ZNF91 ZNF43 ZNF268 ZNF726 ZNF682	3.66e-05	560	34	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF717 ZNF208 ZNF91 ZNF43 ZNF268 ZNF726 ZNF682	3.92e-05	566	34	7	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF208 ZNF91 ZNF43 ZNF726 ZNF682	1.95e-04	320	34	5	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF208 ZNF91 ZNF43 ZNF726 ZNF682	2.12e-04	326	34	5	GO:0001217
GeneOntologyBiologicalProcess	transposable element silencing	ZNF208 ZNF91 ZNF43 ZNF726 MOV10	1.17e-08	46	34	5	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF208 ZNF91 ZNF43 ZNF726 MOV10	1.46e-08	48	34	5	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF208 ZNF91 ZNF43 ZNF726 MOV10	1.80e-08	50	34	5	GO:0032196
HumanPheno	Electronegative electroretinogram	RS1 LRIT3	7.05e-05	18	4	2	HP:0007984
HumanPheno	Abnormal amplitude of dark-adapted bright flash electroretinogram	RS1 LRIT3	7.87e-05	19	4	2	HP:0030478
HumanPheno	Abnormal dark-adapted electroretinogram	RS1 LRIT3	7.87e-05	19	4	2	HP:0030469
HumanPheno	Abnormal dark-adapted bright flash electroretinogram	RS1 LRIT3	7.87e-05	19	4	2	HP:0030470
HumanPheno	Abnormal electroretinogram	POGZ RS1 LRIT3	3.34e-04	226	4	3	HP:0000512
HumanPheno	Abnormal visual electrophysiology	POGZ RS1 LRIT3	5.79e-04	272	4	3	HP:0030453
HumanPheno	Hypermetropia	POGZ RS1 LRIT3	6.86e-04	288	4	3	HP:0000540
MousePheno	decreased eosinophil cell number	ZNF208 ZNF91 ZNF43 ZNF682	4.39e-06	84	19	4	MP:0005012
MousePheno	decreased granulocyte number	ZNF208 ZNF91 ZNF43 ZNF682	3.33e-04	254	19	4	MP:0000334
MousePheno	abnormal eosinophil cell number	ZNF208 ZNF91 ZNF43 ZNF682	3.38e-04	255	19	4	MP:0002602
MousePheno	abnormal eosinophil morphology	ZNF208 ZNF91 ZNF43 ZNF682	3.64e-04	260	19	4	MP:0005061
MousePheno	maternal imprinting	ZNF726 ZNF254	6.48e-04	28	19	2	MP:0003122
Domain	KRAB	ZNF737 ZNF479 ZNF208 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF738 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	8.94e-27	369	32	20	SM00349
Domain	KRAB	ZNF737 ZNF479 ZNF208 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF738 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	9.44e-27	370	32	20	IPR001909
Domain	KRAB	ZNF737 ZNF479 ZNF208 ZNF716 ZNF680 ZNF613 ZNF91 ZNF555 ZNF442 ZNF738 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	4.02e-25	358	32	19	PS50805
Domain	KRAB	ZNF737 ZNF479 ZNF208 ZNF716 ZNF680 ZNF613 ZNF91 ZNF555 ZNF442 ZNF738 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254	2.94e-23	358	32	18	PF01352
Domain	zf-C2H2	ZNF737 ZNF479 ZNF208 ZNF716 POGZ ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	2.78e-21	693	32	20	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF737 ZNF479 ZNF208 ZNF716 POGZ ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	2.55e-20	775	32	20	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF737 ZNF479 ZNF208 ZNF716 POGZ ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	2.68e-20	777	32	20	PS00028
Domain	Znf_C2H2-like	ZNF737 ZNF479 ZNF208 ZNF716 POGZ ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	4.32e-20	796	32	20	IPR015880
Domain	Znf_C2H2	ZNF737 ZNF479 ZNF208 ZNF716 POGZ ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	5.39e-20	805	32	20	IPR007087
Domain	ZnF_C2H2	ZNF737 ZNF479 ZNF208 ZNF716 POGZ ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	5.80e-20	808	32	20	SM00355
Domain	-	ZNF737 ZNF479 ZNF208 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	7.80e-20	679	32	19	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF737 ZNF479 ZNF208 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	1.18e-19	694	32	19	IPR013087
Domain	zf-C2H2_6	ZNF737 ZNF479 ZNF208 ZNF680 ZNF613 ZNF91 ZNF555 ZNF442 ZNF43 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331	3.88e-17	314	32	14	PF13912
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF717 ZNF737 ZNF479 ZNF208 ZNF716 CHEK1 ZNF680 ZNF613 ZNF555 ZNF442 ZNF738 ZNF43 ZNF268 ZNF726 MOBP ZNF682 MOV10 ZNF790 ZNF331 ZNF254 ZNF662	3.72e-16	1387	28	21	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF208 CHEK1 ZNF91 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZNF254	1.09e-05	768	28	9	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF208 CHEK1 ZNF91 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZNF254	1.05e-04	1022	28	9	MM15436
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF208 ZNF716 ZNF91 ZNF43 ZNF726 ZNF682 ZNF254	6.78e-16	29	34	7	14563677
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF208 ZNF91 ZNF43 ZNF726 ZNF254	1.96e-12	15	34	5	15885501
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF208 ZNF91 ZNF43 ZNF726 ZNF682 ZFP82	7.43e-12	49	34	6	9630514
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF737 ZNF208 ZNF680 ZNF91 ZNF555 ZNF738 ZNF726 ZFP82	7.45e-12	181	34	8	37372979
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF737 ZNF208 ZNF91 ZNF43	1.37e-09	16	34	4	8467795
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF208 ZNF716 POGZ ZSCAN20 ZNF91 ZNF43 ZNF726 ZNF790 ZNF254	5.88e-08	808	34	9	20412781
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF208 ZNF91 ZNF43	1.02e-07	10	34	3	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF208 ZNF91 ZNF43	1.40e-07	11	34	3	15469996
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF716 ZNF680 ZSCAN20 ZNF91 ZNF726 ZNF682 MOV10	2.34e-07	451	34	7	36168627
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF208 ZNF91 ZNF43	2.42e-07	13	34	3	19850934
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF726 ZFP82 ZNF254	9.62e-07	20	34	3	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF726 ZFP82 ZNF254	9.62e-07	20	34	3	7479878
Pubmed	The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis.	ZNF726 ZNF254	9.26e-06	5	34	2	24190968
Pubmed	A pair of mouse KRAB zinc finger proteins modulates multiple indicators of female reproduction.	ZNF726 ZNF254	9.26e-06	5	34	2	20042539
Pubmed	The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.	ZNF726 ZNF254	1.39e-05	6	34	2	30846446
Pubmed	The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.	ZNF726 ZNF254	1.94e-05	7	34	2	22801370
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF91 ZNF43	2.59e-05	8	34	2	2023909
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF726 ZFP82 ZNF254	2.96e-05	61	34	3	8662221
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF726 ZNF254	3.33e-05	9	34	2	10360839
Pubmed	Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.	ZNF91 ZNF268	3.33e-05	9	34	2	23665872
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZSCAN20 ZNF43	4.24e-04	31	34	2	2288909
Interaction	TRIM28 interactions	ZNF737 ZNF208 ZNF680 ZNF91 ZNF555 ZNF738 ZNF268 ZNF726 ZNF682 ZFP82 MOV10 ZNF331 ZNF254	1.51e-07	1474	32	13	int:TRIM28
Interaction	ZNF716 interactions	ZNF716 ZNF726	7.32e-06	3	32	2	int:ZNF716
Interaction	ARHGAP24 interactions	ZNF716 ZNF680 ZSCAN20 ZNF91 ZNF726 ZNF682 MOV10	9.06e-06	486	32	7	int:ARHGAP24
Interaction	ZNF479 interactions	ZNF479 ZNF254	6.80e-05	8	32	2	int:ZNF479
Interaction	ZNF254 interactions	ZNF479 ZNF254	1.09e-04	10	32	2	int:ZNF254
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF737 ZNF208 ZNF91 ZNF738 ZNF43 ZNF726 ZNF682 ZNF254	3.37e-14	122	34	8	chr19p12
Cytoband	19p12	ZNF737 ZNF208 ZNF91 ZNF738 ZNF726 ZNF682 ZNF254	4.52e-13	90	34	7	19p12
Cytoband	3p22.1	MOBP ZNF662	4.08e-04	40	34	2	3p22.1
Cytoband	7p11.2	ZNF479 ZNF716	8.87e-04	59	34	2	7p11.2
Cytoband	19q13.12	ZFP82 ZNF790	1.32e-03	72	34	2	19q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF613 ZFP82 ZNF790 MIA ZNF331	1.74e-03	1192	34	5	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr7p11	ZNF479 ZNF716	1.91e-03	87	34	2	chr7p11
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	MOBP ZNF662	8.24e-03	184	34	2	chr3p22
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF717 ZNF737 ZNF479 ZNF208 ZNF716 ZNF680 ZNF613 ZSCAN20 ZNF91 ZNF555 ZNF442 ZNF43 ZNF268 ZNF726 ZNF682 ZFP82 ZNF790 ZNF331 ZNF254 ZNF662	1.70e-22	718	28	20	28
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PTPRM LRIT3	2.56e-02	161	28	2	593
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K4ME3	ZNF208 ZNF91 ZNF43 ZNF726 ZNF682 ZFP82 ZNF254	2.92e-06	497	34	7	MM863
Coexpression	TERAO_AOX4_TARGETS_SKIN_DN	ZNF208 ZNF91 ZNF43	6.39e-06	28	34	3	MM925
Coexpression	MIKKELSEN_ES_ICP_WITH_H3K4ME3	ZNF208 ZNF91 ZNF442 ZNF43 ZNF726 ZNF682 ZFP82 ZNF254	6.96e-06	807	34	8	MM855
Coexpression	COATES_MACROPHAGE_M1_VS_M2_UP	ZNF208 ZNF91 ZNF43 ZNF682	9.16e-06	102	34	4	MM749
Coexpression	LEE_LIVER_CANCER_MYC_DN	ORM1 POGZ NETO2	7.51e-05	63	34	3	M18496
Coexpression	DURAND_STROMA_NS_UP	ZNF208 ZNF91 ZNF43 ZNF682	1.13e-04	194	34	4	MM962
Coexpression	WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	ZNF208 ZNF91 ZNF43 ZNF726 MOV10 ZNF254	2.07e-04	675	34	6	MM1073
Coexpression	ZHONG_PFC_C4_UNKNOWN_INP	ZNF43 ZFP82 ZNF254	2.10e-04	89	34	3	M39084
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	ZNF737 ZNF680 ZNF738 ZNF43 ZNF726 ZNF682 ZNF254	1.98e-11	150	34	7	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF737 FAT1 ZNF613 ZNF555 NETO2	1.80e-07	169	34	5	2833a8a7094e4d407eb923f2bc59b9b112c6bae4
Disease	macrophage migration inhibitory factor measurement	ZNF208 ZNF43	9.39e-04	43	31	2	EFO_0008221
Disease	Chagas cardiomyopathy	ZNF208 IZUMO1R	9.83e-04	44	31	2	EFO_0005529
Disease	Malignant neoplasm of salivary gland	FAT1 NETO2	1.03e-03	45	31	2	C0220636
Disease	Salivary Gland Neoplasms	FAT1 NETO2	1.12e-03	47	31	2	C0036095
Disease	Adenoid Cystic Carcinoma	FAT1 NETO2	4.96e-03	100	31	2	C0010606

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSDSCQEYSDWKEKK	CHEK1	211	O14757
LDCPWKFCDEKVSVD	FAT1	3741	Q14517
DKLYEECIPWKDNAC	IZUMO1R	41	A6ND01
VCKLQCKSEPFWEDD	LRIT3	606	Q3SXY7
SDVVYTDWKKDKCEP	ORM1	171	P02763
EKPYVCDVEGCTWKF	KLF18	991	A0A0U1RQI7
VKCCKYWPDDTEIYK	PTPRM	1006	P28827
PGKVDVKTDKWDFYC	MIA	116	Q16674
DIKPCCNWDAKKGEY	MOV10	591	Q9HCE1
KCKICEWAFESEPLF	POGZ	561	Q7Z3K3
ICKSGCFYQKKEEDW	MOBP	46	Q13875
NCAYPWDENHCKEKK	NETO2	321	Q8NC67
EKPYKCEECGKAFNW	ZNF738	341	Q8NE65
EKPYECKQCGKTFNW	ZNF555	421	Q8NEP9
KPYECNECGKAFIWK	ZNF268	806	Q14587
EKPYKCGECWKSFNQ	ZSCAN20	791	P17040
EKPYECKECKKAFRW	ZNF331	156	Q9NQX6
EKPYKCEECGKAFNW	ZNF682	226	O95780
EKPYKCEECDQTFKW	ZNF716	461	A6NP11
KPYKCEECEQAFKWH	ZNF479	491	Q96JC4
EKPYKCEECGKAFNW	ZNF43	311	P17038
TEEKPYACNWCEKLF	ZNF717	306	Q9BY31
EKPYKCEECGKAFIW	ZNF726	366	A6NNF4
EKPYECKECRKAFSW	ZNF442	541	Q9H7R0
EKPYKCEECGKAFNW	ZNF91	431	Q05481
EKPYECKECWKAFSR	ZFP82	391	Q8N141
ETPYKCEECDKAFSW	ZNF208	1026	O43345
EEPYVCKECGKSFIW	ZNF790	531	Q6PG37
EKPYECTECDKAFRW	ZNF613	341	Q6PF04
EDEGEDPWYQKACKC	RS1	26	O15537
DKPYKCDECHKAFNW	ZNF680	291	Q8NEM1
EKPYKCEECGKAFIW	ZNF254	291	O75437
EKPYKCEECGKAFIW	ZNF254	431	O75437
KPYECQECAKAFVWK	ZNF662	246	Q6ZS27
EKPYKCEECGKAFNW	ZNF737	366	O75373