Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	The role of ZKSCAN3 in the transcriptional regulation of autophagy.	ZKSCAN3 ZKSCAN4	5.23e-06	2	80	2	28581889
Pubmed	Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload.	ZKSCAN3 ZKSCAN4	5.23e-06	2	80	2	37144628
Pubmed	Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and Senescence.	ZKSCAN3 ZKSCAN4	5.23e-06	2	80	2	37175493
Pubmed	The kidney-expressed transcription factor ZKSCAN3 is dispensable for autophagy transcriptional regulation and AKI progression in mouse.	ZKSCAN3 ZKSCAN4	5.23e-06	2	80	2	35841832
Pubmed	BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor.	BCL6B BCL6	5.23e-06	2	80	2	9632807
Pubmed	ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression.	ZKSCAN3 ZKSCAN4	1.57e-05	3	80	2	34504306
Pubmed	Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.	BCL6B BCL6	1.57e-05	3	80	2	17526724
Pubmed	GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg.	HDAC6 BCL6	1.57e-05	3	80	2	29434588
Pubmed	ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis.	ZKSCAN3 ZKSCAN4	1.57e-05	3	80	2	38617741
Pubmed	ZKSCAN3 is a master transcriptional repressor of autophagy.	ZKSCAN3 ZKSCAN4	1.57e-05	3	80	2	23434374
Pubmed	Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP+-induced oxidative stress.	ZKSCAN3 ZKSCAN4	1.57e-05	3	80	2	35124181
Pubmed	BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27.	BCL6B BCL6	1.57e-05	3	80	2	32517789
Pubmed	Bcl6-dependent transcriptional repression by BAZF.	BCL6B BCL6	3.13e-05	4	80	2	12659862
Pubmed	Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets.	ZKSCAN3 ZKSCAN4	3.13e-05	4	80	2	18940803
Pubmed	MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.	HDAC6 BCL6	3.13e-05	4	80	2	23974956
Pubmed	Zkscan3 affects erythroblast development by regulating the transcriptional activity of GATA1 and KLF1 in mice.	ZKSCAN3 ZKSCAN4	3.13e-05	4	80	2	34940950
Pubmed	Functional proteomics mapping of a human signaling pathway.	KMT2B AP2A2 XPO5 CSPG4 PLCL2 ASCC3 TOPORS SMAD9	6.57e-05	591	80	8	15231748
Pubmed	A peptide aptamer to antagonize BCL-6 function.	BCL6B BCL6	7.79e-05	6	80	2	16331266
Pubmed	Identification of SCAN dimerization domains in four gene families.	ZKSCAN3 ZKSCAN4	1.09e-04	7	80	2	11342224
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	MMP28 RGPD1	1.86e-04	9	80	2	28100513
Pubmed	BCoR, a novel corepressor involved in BCL-6 repression.	HDAC6 BCL6	2.32e-04	10	80	2	10898795
Pubmed	Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.	SHMT1 CUBN	3.40e-04	12	80	2	20852008
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	BCL6B ZBTB43 BCL6	4.21e-04	63	80	3	34351428
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	TMEM129 NOP9 AP2A2 XPO5 PROCR CYBC1 CSPG4 TOPORS TAP1 STT3A	4.33e-04	1203	80	10	29180619
Pubmed	Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain.	CSPG4 SMAD9	4.67e-04	14	80	2	26586223
Pubmed	A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.	SHMT1 CUBN	5.38e-04	15	80	2	20615890
Pubmed	Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells.	HDAC6 HCAR1	6.14e-04	16	80	2	15831516
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	COL6A2 CSPG4	6.14e-04	16	80	2	16880404
Pubmed	Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.	PIGL PIGA	6.95e-04	17	80	2	11102867
Pubmed	MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway.	CDKN2D PTCH2	7.81e-04	18	80	2	25422376
Pubmed	The frantic play of the concealed HIV envelope cytoplasmic tail.	AP2A2 RABAC1	7.81e-04	18	80	2	23705972
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HDAC6 EML3 GAA SMAD9	8.59e-04	183	80	4	31932471
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	BCL6B BCL6	8.71e-04	19	80	2	30385546
Pubmed	Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.	ZKSCAN3 ZKSCAN4	8.71e-04	19	80	2	19641492
Pubmed	Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain.	CSPG4 SMAD9	1.07e-03	21	80	2	25406396
Pubmed	Characterization and mapping of human genes encoding zinc finger proteins.	BCL6B BCL6	1.17e-03	22	80	2	1946370
Pubmed	Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.	BCL6B BCL6	1.17e-03	22	80	2	1505991
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	AP2A2 EML3	1.64e-03	26	80	2	24067654
Pubmed	The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.	AP2A2 RABAC1	1.64e-03	26	80	2	23077317
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIFBP CFAP92 XPO5	1.76e-03	103	80	3	10574462
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	PIGL KIFBP ARMH3	1.76e-03	103	80	3	29539633
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ABHD14A COL6A2 CYBC1 ZNF841 BCL6 ASCC3 EML3 CFAP46 SMAD9	1.89e-03	1215	80	9	15146197
Pubmed	Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.	PIGA SMAD9	1.90e-03	28	80	2	19762422
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	BCL6B ZBTB43 BTBD9 BCL6	8.98e-04	134	58	4	861
Drug	PNU-0293363 [326823-19-2]; Up 200; 10uM; PC3; HT_HG-U133A	GPM6B PIGL TSPAN31 AP2A2 ANXA10 DBT EML3	5.88e-06	196	80	7	6568_UP
Drug	carbamazepine; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	ABHD14A PIM2 DSTYK ZBTB43 ZKSCAN3 DBT EML3	6.28e-06	198	80	7	919_DN
Disease	neutrophil measurement	CDKN2D KIFBP MROH6 DSTYK BCL6	1.09e-04	177	78	5	EFO_0803548
Disease	Dystonia, Limb	KMT2B SLC30A10	9.14e-04	17	78	2	C0751093
Disease	Dystonia, Diurnal	KMT2B SLC30A10	9.14e-04	17	78	2	C0393610
Disease	Dystonia, Paroxysmal	KMT2B SLC30A10	1.03e-03	18	78	2	C0393588
Disease	urinary microalbumin measurement	CUBN PPM1H	1.27e-03	20	78	2	EFO_0010967
Disease	Low Grade Lymphoma (neoplasm)	SHMT1 BCL6	1.40e-03	21	78	2	C0079747
Disease	Lymphoma, Intermediate-Grade	SHMT1 BCL6	1.40e-03	21	78	2	C0079741
Disease	High Grade Lymphoma (neoplasm)	SHMT1 BCL6	1.40e-03	21	78	2	C0079740
Disease	Diffuse Mixed-Cell Lymphoma	SHMT1 BCL6	1.40e-03	21	78	2	C0079757
Disease	Lymphoma, Undifferentiated	SHMT1 BCL6	1.40e-03	21	78	2	C0024306
Disease	Reticulosarcoma	SHMT1 BCL6	1.40e-03	21	78	2	C0024302
Disease	Lymphoma, Mixed-Cell	SHMT1 BCL6	1.40e-03	21	78	2	C0024304
Disease	Lymphoma, Diffuse	SHMT1 BCL6	1.40e-03	21	78	2	C3714542
Disease	Lymphoma, Non-Hodgkin, Familial	SHMT1 BCL6	1.54e-03	22	78	2	C4721532
Disease	Lymphoma, Small Noncleaved-Cell	SHMT1 BCL6	1.54e-03	22	78	2	C0079770
Disease	serum alanine aminotransferase measurement	TRMT44 MMP28 PROCR DSTYK NYNRIN SHMT1 TMEM187 SLC30A10	2.09e-03	869	78	8	EFO_0004735

Protein segments in the cluster

Peptide	Gene	Start	Entry
HHHTRLIFVFLVETG	nan	31	Q8N976
LQFHGLVRLVHQERT	PROCR	91	Q9UNN8
HDFGFHNKTVIRILI	ANXA10	261	Q9UJ72
HDHFRVLALARGVNA	CSPG4	2021	Q6UVK1
HVVIHTAGLVDVFGR	HSD3B7	81	Q9H2F3
VGFIHAEATVHLLRS	CFAP46	656	Q8IYW2
VTHALVNIRAIINHF	ARMH3	586	Q5T2E6
VGAFHKSEVRHLVLN	CFAP92	216	Q9ULG3
IHLAVQEGHTAVVSF	CDKN2D	111	P55273
HTQVVALLVAHGAEV	ASZ1	161	Q8WWH4
RVVHLLNDQHLGVVT	AP2A2	191	O94973
VLDAHTRVVQFFHTL	NWD1	406	Q149M9
RAQTLLFSHHAVISV	KCNJ4	181	P48050
QAHRVEVVLLHGKAF	ABHD14A	91	Q9BUJ0
HHFLKTTAALRGQVV	DBT	51	P11182
FGHHVARNVALTTFL	NOP9	596	Q86U38
SHQIFHVLVVAAAFV	ADIPOR1	336	Q96A54
THTLQFRHGFVAVLS	ITGAE	956	P38570
GGFIHSIVQVALILH	OR4N5	151	Q8IXE1
SRVIHVEGQKHIVIF	KMT2B	2661	Q9UMN6
RAAAVLIGFLVHHAS	MROH6	616	A6NGR9
IINLAVVHRFAGHVS	OR51A2	256	Q8NGJ7
IINLAVVHRFARHVS	OR51A4	256	Q8NGJ6
HITVVSIAHGSNIFV	OR6M1	241	Q8NGM8
HVALAGTVAILEQHF	GPM6B	56	Q13491
VVEGIRFLHSQGLVH	DSTYK	761	Q6XUX3
TVNVNASHVVHGRIL	CUBN	1881	O60494
HVLVQSGLTIAVHFE	CUBN	2121	O60494
IQAHLAQGHVAIVLV	GUCD1	136	Q96NT3
VRSVFQGHVTHQALV	IFI44	206	Q8TCB0
NAGVVHVALLTHVDS	IFI44	336	Q8TCB0
SRFVQVAHLRAHVLI	BCL6B	391	Q8N143
HQVSFTLHEGVRVAA	GEMIN7	76	Q9H840
HVGAGVVHAINAIVR	COL6A2	916	P12110
TLFRAGHDQVVVLLH	CYBC1	91	Q9BQA9
VVLVNRVHLVTQHGE	DHX58	51	Q96C10
FVQVAHLRAHVLIHT	BCL6	611	P41182
TLFHQAHVAGETVAR	GAA	711	P10253
FTAVLISGVVHEIGH	MBTPS2	161	O43462
HHAVNTISTRVAAGI	HCAR1	121	Q9BXC0
HVHDRGQVFVNTVSI	GLB1L2	446	Q8IW92
IVAQAHAHEGSIFAL	EML3	506	Q32P44
VAVAARHAQTISGHA	HDAC6	626	Q9UBN7
IRIVGTHNTANEVFH	BTBD9	536	Q96Q07
LQRHVIARGHAFVLV	DIRAS3	101	O95661
RIATVQHEFLHALGF	MEP1B	146	Q16820
AVRLAVIEFHLGVNH	KIFBP	91	Q96EK5
HTAVAQVLLQHVFAR	NYNRIN	1656	Q9P2P1
AHITFAILDAVHGNI	RGPD1	641	P0DJD0
GRNLFVVLAHEIGHT	MMP28	231	Q9H239
VAHFIHRGIELTLQI	SHMT1	421	P34896
AEAVQVRGSVHFALH	SYTL1	261	Q8IYJ3
VHLHFTRRNLVLAAG	TAF5	781	Q15542
SHQVFQVVNGRVHIR	TRMT44	676	Q8IYL2
HVARVLLQHIEVNGI	PIGL	126	Q9Y2B2
QVVAAIQHCHSRGVV	PIM2	146	Q9P1W9
VGIAHLTATVQAFTH	PTCH2	591	Q9Y6C5
GEVLAHASLFVHVAI	PLCL2	866	Q9UPR0
HVLHFFHITIDIRNV	STT3A	101	P46977
VHSHLQGEVFGAVLR	TAP1	256	Q03518
GIANRITAATHVHEA	STARD9	206	Q9P2P6
AQLLAQSVHHGFEVV	SMAD9	391	O15198
HSQSVLFVGLREHVV	SEMA5A	466	Q13591
VLQVSLQRVHFGFHK	ASCC3	2081	Q8N3C0
VEHHTFRLQGLQAVL	C10orf53	21	Q8N6V4
SIVVQGHIFRAHKAV	ZBTB43	36	O43298
EHKDVRNVLVQGHIF	PIGA	291	P37287
IREIFHHAGIHNVTI	SLC30A10	366	Q6XR72
SGAAVVASRLLQHHI	PPM1H	156	Q9ULR3
VHAARHAGFTTVLLA	TMEM102	291	Q8N9M5
LHARGHQVVVLTLEV	UGT1A5	51	P35504
AIVRHFGLQILEHVV	XPO5	61	Q9HAV4
VAGLVGAVNHHQVLL	TSPAN31	61	Q12999
LELAGVTHVFHVQQT	SIRPD	21	Q9H106
VVIGSHAAFHQIEAV	RABAC1	161	Q9UI14
AFHRGSLLTVHQIVH	ZNF841	181	Q6ZN19
TFIGSSALVIHQRVH	ZKSCAN4	356	Q969J2
VLFGAHGSLVNIVQH	TOPORS	306	Q9NS56
VVAAVGQALRTHRHY	TMEM187	171	Q14656
FIGSSALVIHQRVHT	ZKSCAN3	351	Q9BRR0
HVSVFGLRNAFLIQH	PLEKHG7	621	Q6ZR37
RAAHVVIHQSLGDLF	TMEM129	246	A0AVI4
LLAIHQRVHTGLRAF	ZNF628	496	Q5EBL2