Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase regulator activity

IQSEC1 CAVIN4 AGAP9 RASGRF1 TBC1D22A GPS2 NUCB2

8.15e-05507427GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

IQSEC1 CAVIN4 AGAP9 RASGRF1 TBC1D22A GPS2 NUCB2

8.15e-05507427GO:0060589
GeneOntologyBiologicalProcessregulation of transcription by RNA polymerase III

DHX36 ICE1 SF3B1

3.22e-0532403GO:0006359
GeneOntologyCellularComponenttranscription elongation factor complex

ICE1 SUPT6H SUPT16H

1.55e-0456393GO:0008023
GeneOntologyCellularComponentcell division site

MYH10 RAB11FIP4 TUBGCP2

4.47e-0480393GO:0032153
GeneOntologyCellularComponentGolgi medial cisterna

GOLGA5 NUCB2

8.37e-0423392GO:0005797
DomainGonadal

DGCR6 DGCR6L

4.70e-062412IPR010849
DomainDGCR6

DGCR6 DGCR6L

4.70e-062412PF07324
DomainIQ

IQSEC1 CEP131 MYH10 RASGRF1

1.75e-0571414PF00612
DomainIQ_motif_EF-hand-BS

IQSEC1 CEP131 MYH10 RASGRF1

4.45e-0590414IPR000048
DomainIQ

IQSEC1 CEP131 MYH10 RASGRF1

5.07e-0593414PS50096
DomainIQ

CEP131 MYH10 RASGRF1

7.44e-0481413SM00015
DomainZnF_U1

ZNF830 SCAPER

1.84e-0329412SM00451
DomainZnf_U1

ZNF830 SCAPER

1.84e-0329412IPR003604
DomainQuinoprotein_ADH-like_supfam

WDR87 EML6

6.04e-0353412IPR011047
DomainCa/CaM-dep_Ca-dep_prot_Kinase

BRSK1 NUAK1

1.01e-0269412IPR020636
DomainEF_HAND_1

RAB11FIP4 USP32 NUCB2

1.01e-02204413PS00018
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

CUL3 LAMA4 DHX36 PHF3 SUPT6H UTP14A SUPT16H

2.86e-0825144728077445
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

IQSEC1 SF3B1 GOLGA5 UAP1L1 PHF3 SCAPER

4.84e-0723344637704626
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

ZNF830 MYH10 SF3B1 PHF3 UTP14A SUPT16H

1.50e-0628344630585729
Pubmed

NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.

NUAK1 STK38L

1.56e-06244216488889
Pubmed

Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.

DGCR6 DGCR6L

1.56e-06244215821931
Pubmed

Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.

DGCR6 DGCR6L

1.56e-06244222832905
Pubmed

A mouse gene (Dgcr6) related to the Drosophila gonadal gene is expressed in early embryogenesis and is the homolog of a human gene deleted in DiGeorge syndrome.

DGCR6 DGCR6L

1.56e-0624429605865
Pubmed

Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.

DGCR6 DGCR6L

1.56e-06244211157784
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CUL3 DHX36 ICE1 RBM12 AGAP9 NUAK1 SUPT6H

4.26e-0652944714621295
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

MYH10 SF3B1 PHF3 SUPT6H UTP14A SUPT16H

4.31e-0634044629478914
Pubmed

Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids.

CEP131 UTP14A

4.69e-0634428529672
Pubmed

Integration of cytogenetic with recombinational and physical maps of mouse chromosome 16.

DGCR6 DGCR6L

1.56e-05544210395793
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

CUL3 DHX36 MYH10 SF3B1 TUBGCP2 ARGLU1 PHF3 UTP14A SUPT16H

2.31e-05125744936526897
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

IQSEC1 CUL3 CEP131 MYH10 SF3B1 BRSK1 ARGLU1 SUPT16H

2.46e-0596344828671696
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CEP131 ICE1 TUBGCP2 GOLGA5 TBC1D22A PHF3 NUCB2

3.49e-0573344734672954
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CUL3 MSH3 RBM12 SF3B1 ARGLU1 PHF3 SUPT6H SUPT16H

3.54e-05101444832416067
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

IQSEC1 DHX36 MYH10 SF3B1 ARGLU1 SUPT6H UTP14A SUPT16H

5.60e-05108244838697112
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

FAM184B MYH10 SF3B1 RNF17 CCDC191 EML6 NUCB2 UTP14A SUPT16H

6.74e-05144244935575683
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

ICE1 PHF3 UTP14A SUPT16H

7.51e-0517744426206133
Pubmed

Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.

SF3B1 STK38L SUPT6H SUPT16H

8.36e-0518244426527279
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

FAM184B CEP131 SF3B1 GOLGA5 ARGLU1 SUPT6H NUCB2 UTP14A SUPT16H

8.52e-05148744933957083
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

MYH10 SF3B1 RNF17 SUPT6H SUPT16H

8.78e-0535844532460013
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

CUL3 ICE1 SF3B1 RASGRF1 PHF3

9.13e-0536144526167880
Pubmed

Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation.

DGCR6 DGCR6L

1.02e-04124429383280
Pubmed

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.

SUPT6H SUPT16H

1.02e-041244230479348
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

CUL3 DHX36 TUBGCP2 PHF3 UTP14A

1.02e-0437044522922362
Pubmed

Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes.

CUL3 UTP14A

1.21e-041344211700028
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

CUL3 CEP131 MYH10 NUAK1 USP32 SUPT16H SCAPER

1.47e-0492244727609421
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

DHX36 MYH10 SF3B1 ARGLU1 PHF3 WDR87 GPS2 UTP14A

1.50e-04124744827684187
Pubmed

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

BRSK1 NUAK1

1.63e-041544214976552
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DHX36 MYH10 SF3B1 PHF3 SUPT6H UTP14A

1.65e-0465344622586326
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

IQSEC1 MSH3 SUPT6H SUPT16H

1.80e-0422244437071664
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ZNF830 ICE1 SF3B1 ARGLU1 PHF3 UTP14A SUPT16H

1.81e-0495444736373674
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

DHX36 MYH10 SF3B1 PHF3 SUPT6H UTP14A SUPT16H

2.25e-0498944736424410
Pubmed

The contribution of de novo coding mutations to autism spectrum disorder.

MYH10 PHF3

2.36e-041844225363768
Pubmed

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

ICE1 STK38L

2.36e-041844220064376
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

CUL3 ICE1 MYH10 TUBGCP2 SUPT6H USP32 SUPT16H

2.48e-04100544719615732
Pubmed

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.

MYH10 TUBGCP2

2.64e-041944216105984
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

DHX36 CEP131 TUBGCP2 GOLGA5

2.87e-0425144429778605
Pubmed

Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse.

DGCR6 DGCR6L

2.93e-04204429740669
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

SF3B1 ARGLU1 UTP14A SUPT16H

3.23e-0425944430404004
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

RAB11FIP4 BRSK1 GPS2

3.42e-0410744311347906
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

CUL3 DHX36 PHF3 UTP14A SUPT16H SCAPER

3.69e-0475944635915203
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

IQSEC1 CUL3 DHX36 MYH10 SF3B1 BRSK1 ARGLU1 SCAPER

3.81e-04143144837142655
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

IQSEC1 CUL3 AGAP9 PHF3

4.39e-0428144428706196
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

DHX36 TUBGCP2 PHF3 SCAPER

4.39e-0428144424163370
Pubmed

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

LAMA4 MYH10 SF3B1 WDR87

4.39e-0428144430455355
Pubmed

Neural tube defects by NUAK1 and NUAK2 double mutation.

MYH10 NUAK1

4.61e-042544222689267
Pubmed

Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.

SUPT6H SUPT16H

4.99e-042644233298525
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

DHX36 RBM12 SF3B1 SUPT6H UTP14A SUPT16H

5.10e-0480744622681889
Pubmed

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

SF3B1 TUBGCP2

5.79e-042844229653964
Pubmed

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.

DGCR6 DGCR6L

5.79e-042844210963672
Pubmed

Identification of 14-3-3epsilon substrates from embryonic murine brain.

CEP131 BRSK1 NUAK1

6.32e-0413244316944949
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

DHX36 RBM12 GOLGA5

6.46e-0413344315144186
Pubmed

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

BRSK1 NUAK1

6.65e-043044216306228
Pubmed

Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.

DGCR6 DGCR6L

6.65e-04304429405660
Pubmed

Isolation and characterization of proteins associated with histone H3 tails in vivo.

SF3B1 SUPT16H

6.65e-043044217403666
Pubmed

BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.

CUL3 SF3B1

7.11e-043144223086144
Pubmed

STK11 is required for the normal program of ciliated cell differentiation in airways.

BRSK1 NUAK1

7.11e-043144231636950
Pubmed

Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.

DGCR6 DGCR6L

8.06e-043344210704284
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

DHX36 MYH10 MSH3 SF3B1

8.95e-0434044424332808
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

DHX36 MYH10 TUBGCP2 SUPT16H

9.05e-0434144432971831
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

CUL3 MSH3 UTP14A

9.15e-0415044330154076
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

DHX36 MYH10 SF3B1 SUPT16H

9.35e-0434444430333137
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

MYH10 SF3B1 SUPT6H UTP14A SUPT16H

9.72e-0460544528977666
Pubmed

Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.

DGCR6 DGCR6L

1.01e-033744210337614
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

DHX36 MYH10 SF3B1 NUAK1 STK38L GPS2 GAS8

1.07e-03128444717353931
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

MSH3 DGCR6 RAB11FIP4 SF3B1 ARGLU1 UAP1L1 USP32

1.07e-03128544735914814
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ICE1 MYH10 RBM12 SF3B1 GOLGA5 UTP14A

1.09e-0393444633916271
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

MSH3 SF3B1 ARGLU1 PHF3 SUPT6H GPS2 SUPT16H

1.11e-03129444730804502
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

SF3B1 SUPT6H UTP14A

1.16e-0316344322113938
Pubmed

A protein interaction landscape of breast cancer.

MYH10 MSH3 NUAK1 NUCB2 SUPT16H

1.20e-0363444534591612
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

MYH10 SF3B1 TUBGCP2 SUPT6H SUPT16H

1.23e-0363844533239621
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

IQSEC1 DHX36 MYH10 SF3B1 ARGLU1 UTP14A SUPT16H

1.24e-03131844730463901
Pubmed

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.

DGCR6 DGCR6L

1.24e-034144225452572
InteractionDDX23 interactions

MYH10 SF3B1 NUAK1 ARGLU1 PHF3 SUPT6H UTP14A SUPT16H

5.66e-06480428int:DDX23
InteractionPYHIN1 interactions

CUL3 LAMA4 DHX36 PHF3 SUPT6H UTP14A SUPT16H

8.32e-06358427int:PYHIN1
Cytoband17q11.2

RAB11FIP4 SUPT6H RSKR

1.65e-0411044317q11.2
Cytoband17p13

MYH10 GPS2

4.94e-043444217p13
CytobandEnsembl 112 genes in cytogenetic band chr17q11

RAB11FIP4 SUPT6H RSKR

6.01e-04171443chr17q11
GeneFamilyEF-hand domain containing

RAB11FIP4 USP32 NUCB2

1.72e-03219203863
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AGAP9 RASGRF1

2.15e-02206202682
DrugB202

DGCR6 DGCR6L

3.48e-062432CID006435965
DrugB 207

DGCR6 DGCR6L

2.09e-054432CID000063369
DrugMethapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; PC3; HT_HG-U133A

GMEB1 SF3B1 TBC1D22A PHF3 GAS8

2.93e-051914356644_DN
DrugICI182,780; Up 200; 1uM; PC3; HT_HG-U133A

MYH10 RBM12 SF3B1 PHF3 SCAPER

3.24e-051954356918_UP
DrugDemecarium bromide [56-94-0]; Down 200; 5.6uM; HL60; HG-U133A

GMEB1 MSH3 TUBGCP2 STK38L SCAPER

3.32e-051964351781_DN
DrugCephapirin sodium salt [24356-60-3]; Down 200; 9uM; HL60; HT_HG-U133A

IQSEC1 UAP1L1 PHF3 SUPT6H SCAPER

3.48e-051984352730_DN
DrugRiluzole hydrochloride; Down 200; 14.8uM; PC3; HT_HG-U133A

IQSEC1 TBC1D22A PHF3 SUPT6H SCAPER

3.56e-051994357365_DN
DrugGlipizide [29094-61-9]; Up 200; 9uM; HL60; HG-U133A

IQSEC1 CUL3 LAMA4 MSH3 TUBGCP2

3.65e-052004352008_UP
DrugRolipram [61413-54-5]; Down 200; 14.6uM; MCF7; HT_HG-U133A

GMEB1 TUBGCP2 STK38L TBC1D22A UTP14A

3.65e-052004356449_DN
Diseaseproline measurement, amino acid measurement

DGCR6 DGCR6L

1.88e-055412EFO_0005134, EFO_0009773
DiseaseBardet-Biedl syndrome (implicated_via_orthology)

CEP131 SCAPER

1.03e-0411412DOID:1935 (implicated_via_orthology)
Diseaseproline measurement

DGCR6 DGCR6L

5.99e-0426412EFO_0009773

Protein segments in the cluster

PeptideGeneStartEntry
MHQVRDREMPEVVEI

AGAP9

206

Q5VTM2
IVEEQRKIHEERMKL

ARGLU1

226

Q9NWB6
HIMMERERKRQEEEE

GPS2

21

Q13227
VEHRIREEQRAMDQK

DGCR6

126

Q14129
QKRIEERHREMENAI

CAVIN4

51

Q5BKX8
VHVVTLEDMREIEKN

RBM12

616

Q9NTZ6
VHRVHELEEMVKDQE

RAB11FIP4

376

Q86YS3
KDEIQGVIDEIRMHL

MSH3

716

P20585
LRTEEKVVAEMEEHQ

GMEB1

546

Q9Y692
MELEELRHEKEMQRE

GOLGA5

466

Q8TBA6
IAEVQEMEKHRIESE

IQSEC1

861

Q6DN90
AREVETLRQEHRKEM

FAM184B

851

Q9ULE4
MHRDVKVENILLDER

RSKR

226

Q96LW2
RELEEKMHEQEKIRE

GOLGA6L22

316

H0YM25
EFMVEEHELRKERIQ

TUBGCP2

406

Q9BSJ2
EEERLRMREHVMNEV

NUCB2

291

P80303
RDILHETKTQMEVRE

ICE1

476

Q9Y2F5
ERAVVHMDERREEQI

DHX36

81

Q9H2U1
KVEARINEEIERVMH

CUL3

236

Q13618
EEEIQREMVKLRREI

CCDC191

246

Q8NCU4
VEHRIREEQRAMDQK

DGCR6L

126

Q9BY27
HRELRSEEENQEKMI

BRSK1

336

Q8TDC3
RDMTEVVHIKDRKEV

EML6

396

Q6ZMW3
DESIRRHMEQIEQRK

SCAPER

751

Q9BY12
EKGREEQERRHQMEL

CEP131

841

Q9UPN4
VEGELEEMERKHQQL

MYH10

871

P35580
LKEIFMQVEDERRHA

MYH10

1851

P35580
HEKQQERVREQMEVV

LAMA4

516

Q16363
MLEKEQVAHIRAERD

STK38L

126

Q9Y2H1
IKDEQDMVHIRREIE

NUAK1

91

O60285
RVMEIVDADEKVRHS

SUPT16H

201

Q9Y5B9
RIMHDEVSETENIRK

RASGRF1

421

Q13972
ALEHMQKQTIEERER

RNF17

171

Q9BXT8
DAQMLIEDVKRIVHE

SUPT6H

856

Q7KZ85
MREQHLTKEEREIRQ

SF3B1

156

O75533
HKILEDMERRGVEFV

UAP1L1

236

Q3KQV9
NRHTIEMIEKEQREV

PHF3

1031

Q92576
EELEDEEERNHRQMI

UTP14A

581

Q9BVJ6
ALEEVKEAMQRIHDR

VAT1L

356

Q9HCJ6
MLEELVSRIDEQVHR

TBC1D22A

391

Q8WUA7
IEKAEIHEKVVERRE

ZNF830

226

Q96NB3
KELVLMEHEGRDVVI

SLC9C2

786

Q5TAH2
VIRHKEVMPREEEQA

WDR87

1336

Q6ZQQ6
VIREEMERMLHVVDG

USP32

111

Q8NFA0
MSKEQVEEHVSRIRE

GAS8

26

O95995
DREMEEAEERHQVEI

GAS8

81

O95995