Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH9 DNHD1 DNAH3 DYNC2H1

2.84e-05182034GO:0008569
GeneOntologyMolecularFunctionphosphatidylinositol phosphate binding

INPPL1 FERMT2 ARAP2 FGD2 CGAS MYO1B CADPS EXOC1 PARD3 SNX5

3.81e-0519920310GO:1901981
GeneOntologyMolecularFunctionvolume-sensitive anion channel activity

LRRC8E LRRC8C LRRC8B

8.31e-0592033GO:0005225
GeneOntologyMolecularFunctionphosphatidylinositol binding

INPPL1 FERMT2 ARAP2 FGD2 CGAS MYO1B CADPS SNX25 SBF2 EXOC1 PARD3 SNX5

9.96e-0531620312GO:0035091
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

INPPL1 FERMT2 ARAP2 MYO1B PARD3

1.37e-04492035GO:0005547
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH9 DNHD1 DNAH3 DYNC2H1

1.75e-04282034GO:0051959
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYO1A KIF14 DNAH9 DNHD1 DNAH3 DYNC2H1 MYO1B

2.06e-041182037GO:0003774
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH9 DNHD1 DNAH3 DYNC2H1

5.27e-04372034GO:0045505
GeneOntologyMolecularFunctioncalmodulin binding

MYO1A DAPK2 RYR3 ITPKB CAMSAP1 IQCG UBR4 MYO1B USP6

5.97e-042302039GO:0005516
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF14 DNAH9 DNHD1 DNAH3 DYNC2H1

7.32e-04702035GO:0003777
GeneOntologyBiologicalProcessimport into cell

ABCA1 MYO1A ABCA13 INPPL1 BCR ALMS1 C4A C4B PLCG2 SLC9A6 LRRC8E DOCK2 LRRC8C RALA RALB SYNE1 MYO1B HEATR5A CUBN LCN2 USP6 MTMR6 TLR2 LRRC8B PARD3 FLOT1 SNX5

7.29e-06107420327GO:0098657
GeneOntologyBiologicalProcessendocytosis

ABCA1 MYO1A ABCA13 INPPL1 BCR ALMS1 C4A C4B PLCG2 DOCK2 RALA RALB SYNE1 MYO1B HEATR5A CUBN USP6 MTMR6 TLR2 PARD3 FLOT1 SNX5

2.35e-0582720322GO:0006897
GeneOntologyBiologicalProcesscyclic-GMP-AMP transmembrane import across plasma membrane

LRRC8E LRRC8C LRRC8B

5.07e-0582033GO:0140361
GeneOntologyBiologicalProcesspositive regulation of endocytosis

ABCA13 BCR ALMS1 C4A C4B PLCG2 DOCK2 SYNE1 PARD3 FLOT1

5.18e-0521320310GO:0045807
DomainDynein_HC_stalk

DNAH9 DNHD1 DNAH3 DYNC2H1

1.22e-05142024IPR024743
DomainDynein_heavy_dom-2

DNAH9 DNHD1 DNAH3 DYNC2H1

1.22e-05142024IPR013602
DomainDHC_N2

DNAH9 DNHD1 DNAH3 DYNC2H1

1.22e-05142024PF08393
DomainMT

DNAH9 DNHD1 DNAH3 DYNC2H1

1.22e-05142024PF12777
DomainLRRC8_Pannexin-like

LRRC8E LRRC8C LRRC8B

1.23e-0552023IPR021040
DomainPannexin_like

LRRC8E LRRC8C LRRC8B

1.23e-0552023PF12534
DomainDHC_fam

DNAH9 DNHD1 DNAH3 DYNC2H1

1.65e-05152024IPR026983
DomainDynein_heavy

DNAH9 DNHD1 DNAH3 DYNC2H1

1.65e-05152024PF03028
DomainDynein_heavy_dom

DNAH9 DNHD1 DNAH3 DYNC2H1

1.65e-05152024IPR004273
Domain-

NAIP TSHR PXDNL XRRA1 FBXO39 LRRC8E LRRC8C LRRIQ3 PRAMEF15 PRAMEF4 LMOD2 TLR2 LRRC8B

4.94e-05321202133.80.10.10
DomainL_dom-like

NAIP TSHR PXDNL XRRA1 FBXO39 LRRC8E LRRC8C LRRIQ3 PRAMEF15 PRAMEF4 LMOD2 TLR2 LRRC8B

6.16e-0532820213IPR032675
DomainMacrogloblnA2_thiol-ester-bond

A2M C4A C4B

6.71e-0582023IPR019565
DomainThiol-ester_cl

A2M C4A C4B

6.71e-0582023PF10569
DomainMacrogloblnA2_CS

A2M C4A C4B

6.71e-0582023IPR019742
DomainFlot

FLOT2 FLOT1

1.16e-0422022PF15975
DomainFlotillin_C

FLOT2 FLOT1

1.16e-0422022IPR031905
DomainFlotillin_fam

FLOT2 FLOT1

1.16e-0422022IPR027705
DomainRal

RALA RALB

1.16e-0422022IPR028412
DomaintRNA-bd_arm

KIAA0408 FYCO1 CNTLN PIBF1

1.19e-04242024IPR010978
DomainLRR_5

TSHR LRRC8C LRRC8B

1.41e-04102023PF13306
DomainLRR_5

TSHR LRRC8C LRRC8B

1.41e-04102023IPR026906
DomainA2M

A2M C4A C4B

1.41e-04102023PF00207
DomainA2M_N_2

A2M C4A C4B

1.41e-04102023IPR011625
DomainA2M_comp

A2M C4A C4B

1.41e-04102023IPR011626
DomainA2M_recep

A2M C4A C4B

1.41e-04102023PF07677
DomainA2M_comp

A2M C4A C4B

1.41e-04102023PF07678
DomainA2M_N

A2M C4A C4B

1.41e-04102023PF01835
DomainA2M_N

A2M C4A C4B

1.41e-04102023IPR002890
DomainA-macroglobulin_rcpt-bd

A2M C4A C4B

1.41e-04102023IPR009048
DomainALPHA_2_MACROGLOBULIN

A2M C4A C4B

1.41e-04102023PS00477
DomainA2M_N_2

A2M C4A C4B

1.41e-04102023PF07703
DomainMacroglobln_a2

A2M C4A C4B

1.41e-04102023IPR001599
DomainARM-type_fold

TRPC4AP STAG1 SCYL1 NCBP1 RYR3 ARMH3 DOCK2 UBR4 HEATR5A PPP6R1 LTN1 LRBA

3.35e-0433920212IPR016024
DomainDynein_heavy_chain_D4_dom

DNAH9 DNAH3 DYNC2H1

4.16e-04142023IPR024317
DomainATPase_dyneun-rel_AAA

DNAH9 DNAH3 DYNC2H1

4.16e-04142023IPR011704
DomainAAA_8

DNAH9 DNAH3 DYNC2H1

4.16e-04142023PF12780
DomainAAA_5

DNAH9 DNAH3 DYNC2H1

4.16e-04142023PF07728
DomainPIN_4

SWT1 SMG6

6.88e-0442022PF13638
DomainTerpenoid_cyclase/PrenylTrfase

A2M C4A C4B

9.02e-04182023IPR008930
DomainAAA

ABCA1 ABCA13 NAIP DNAH9 RAD17 DNAH3 DYNC2H1

9.84e-041442027SM00382
DomainAAA+_ATPase

ABCA1 ABCA13 NAIP DNAH9 RAD17 DNAH3 DYNC2H1

9.84e-041442027IPR003593
DomainAnaphylatoxin_comp_syst

C4A C4B

1.14e-0352022IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

1.14e-0352022IPR001840
DomainLRR

PXDNL XRRA1 FBXO39 LRRC8E LRRC8C LRRIQ3 TLR2 LRRC8B

1.58e-032012028PS51450
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

AFTPH DAPK2 INPPL1 BCR ITPKB MOB2 CEP170 FSIP2 ALMS1 KIF14 CAMSAP1 PIBF1 SEC23B ARAP2 FLOT2 INTS12 RAB11FIP1 VPS13D AKAP11 TNFAIP3 PARD3 AQR

1.08e-088612062236931259
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

SPTBN2 RABL3 PTPRM CAMSAP1 FERMT2 PLXNB1 ARAP2 IQCG RALA RALB FLOT2 RAB11FIP1 PARP14 CRACDL LRBA PARD3 FLOT1

6.08e-085692061730639242
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

BTBD1 TUBA4A TUBA1B COPA DYNC2H1 TMEM14A UBR4 MYO1B PPP6R1 MTMR6 SMARCD1 EXOC1 ECE2

7.66e-083222061326514267
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

GTPBP4 TBC1D9B SPTBN2 SLC35E1 NCBP1 SSB RABL3 CEP170 COG6 DDX54 KIF14 PLS3 FLOT2 CCDC22 COPA JADE2 UBR4 CGAS MYO1B PPP6R1 LETM1 ARPC2 LTN1 SDF4 PCMTD2 EXOC1 FLOT1

1.32e-0714402062730833792
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TBC1D9B SPTBN2 CEP170 PARP4 ALMS1 DHTKD1 DOCK2 SEC16B DYNC2H1 NTNG1 VPS13D PTCD1 SBF2 LTN1 UNC80

2.97e-074932061515368895
Pubmed

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

LRRC8E LRRC8C CGAS LRRC8B

5.70e-0712206432277911
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

GTPBP4 AFTPH CENPC SPTBN2 ANKLE2 RABL3 DDX54 PIBF1 FERMT2 PLS3 FLOT2 DYNC2H1 SYNE1 UBR4 NOL11 PPP6R1 RAB11FIP1 LETM1 PTCD1 SDF4 AKAP11 TMEM131 PARD3 FLOT1 AQR SNX5

8.63e-0714872062633957083
Pubmed

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.

LRRC8E LRRC8C LRRC8B

2.03e-065206335777784
Pubmed

LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.

LRRC8E LRRC8C LRRC8B

2.03e-065206315094057
Pubmed

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

LRRC8E LRRC8C LRRC8B

2.03e-065206324790029
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

HK3 ANKLE2 FERMT2 PLXNB1 PRAMEF11 RAD17 PRAMEF15 NOL11 PRAMEF4 CUBN LETM1 MTMR6 PTCD1 SBF2 LTN1 SDF4 TMEM131 TNFAIP3 PARD3 BTG4 SNX5

2.19e-0610842062111544199
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

STAG1 SPTBN2 NCBP1 BTBD1 RYR3 TUBA1B ZNF624 COPA FOLH1 JADE2 RBL2 SYNE1 UBR4 ADAMTS8 CADPS TMEM131 PCMTD2 EXOC1 LRBA FLOT1 ZMYM4 ECE2 SNX5

2.64e-0612852062335914814
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

A2M GTPBP4 TRPC4AP SCYL1 BCR RABL3 MOB2 KIF14 PLCG2 COPA DYNC2H1 SYNE1 RAB11FIP1 LETM1 ARPC2 SNRPA ZMYM4

2.97e-067542061735906200
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

CNTLN BCR PARP4 CA2 IQCG DNHD1 RALA COL6A3 FLOT2 DYNC2H1 JADE2 RBL2 OLFM4 MYO1B CUBN LCN2 ARPC2 VPS13D CTNS FLOT1

3.05e-0610162062019056867
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

AFTPH SPTBN2 CNTLN ANKLE2 BCR ALMS1 KIF14 CAMSAP1 PIBF1 FERMT2 PLS3 LCA5 FLOT2 CCDC22 ARPC2 MTMR6 TMEM131 FLOT1

3.78e-068532061828718761
Pubmed

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.

CEP170 TUBA1B PIBF1 FERMT2 MYO1B SMARCD1 PARD3 FLOT1

5.21e-06159206830581152
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

DIS3L2 SPTBN2 ARHGEF38 BCR TUBA4A TUBA1B DNAH9 PLS3 SYNE1 MYO1B SNRPA

5.43e-063332061132665550
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

A2M GTPBP4 SPTBN2 NCBP1 TUBA4A TASOR2 CEP170 TUBA1B DDX54 KIF14 PLS3 RALA FLOT2 TENT4B COPA CGAS NOL11 MYO1B ARPC2 SNRPA FLOT1 AQR

6.29e-0612572062236526897
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

GTPBP4 FER1L6 DDX54 CAMSAP1 DNHD1 SYNE1 MYO1B SNX25 LRBA

1.19e-05234206936243803
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GTPBP4 NCBP1 SSB TUBA1B DDX54 KIF14 PLS3 CA2 DNHD1 RALA FLOT2 TENT4B COPA DYNC2H1 SYNE1 UBR4 NOL11 MYO1B LETM1 ARPC2 SNRPA FLOT1 AQR

1.41e-0514252062330948266
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

TUBA1B ALMS1 DNHD1 COL6A3 DYNC2H1 SYNE1 PARP14 CFAP44

1.70e-05187206826460568
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

SETD1A IFT140 TRPC4AP DAPK2 ARHGEF38 IRF5 COG6 ARMH3 PLS3 PRAMEF11 ARAP2 RALA RALB SEC16B INTS12 PRAMEF15 PRAMEF4 ARPC2 RDH16 CRACDL SNX5

1.73e-0512422062130973865
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

SLC35E1 BCR RABL3 TUBA4A CEP170 PARP4 DDX54 AHR DYNC2H1 MYO1B PPP6R1 VPS13D SDF4 TMEM131

1.74e-056062061436538041
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

CENPC SPTBN2 NCBP1 ANKLE2 TUBA1B PTPRM DDX54 KIF14 PIBF1 CCDC22 COPA MYO1B PPP6R1 RAB11FIP1 LETM1 MTMR6 SBF2 LTN1 SDF4

1.74e-0510492061927880917
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

SETD1A TBC1D9B NCBP1 BCR FLOT2 COPA UBR4 MYO1B LTN1 PARD3

1.94e-053132061038270169
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

INPPL1 BCR TUBA1B KIF14 CAMSAP1 PIBF1 CCDC22 AKAP11 SNX5

2.07e-05251206929778605
Pubmed

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

CEP170 KIF14 CAMSAP1 PLS3 PPP6R1

2.26e-0557206529089450
Pubmed

Defining the membrane proteome of NK cells.

GTPBP4 SCYL1 FYCO1 ANKLE2 BCR PARP4 DDX54 KIF14 SLC27A3 DOCK2 LRRC8C FLOT2 COPA UBR4 PARP14 SDF4 EXOC1 LRBA FLOT1 AQR

2.31e-0511682062019946888
Pubmed

Ral GTPases regulate exocyst assembly through dual subunit interactions.

RALA RALB EXOC1

2.38e-0510206314525976
Pubmed

Protein partners in the life history of activated fibroblast growth factor receptors.

TUBA4A TUBA1B PLCG2 COPA PARD3

2.68e-0559206518022941
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

GTPBP4 PLGRKT SCYL1 SSB ANKLE2 RABL3 WARS2 ELOVL2 ALMS1 DDX54 DHTKD1 SEC23B SMG6 FLOT2 COPA SYNE1 UBR4 NOL11 LETM1 VPS13D AKAP11 TMEM131 FLOT1

3.01e-0514962062332877691
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

A2M GTPBP4 SPTBN2 SSB CNTLN TUBA4A CEP170 TUBA1B PARP4 KIF14 C4A PLS3 NOL11 PTCD1 EFCAB7

3.48e-057322061534732716
Pubmed

Inactivating mutations of tumor suppressor genes ABCA1 and CAPN13 in colorectal cancers.

ABCA1 CAPN13

3.49e-052206232088085
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

3.49e-052206222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

3.49e-052206216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

3.49e-052206215998580
Pubmed

Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system.

RALA RALB

3.49e-052206231201267
Pubmed

RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation.

RALA RALB

3.49e-052206231201266
Pubmed

RalA and RalB differentially regulate development of epithelial tight junctions.

RALA RALB

3.49e-052206222013078
Pubmed

Differential involvement of RalA and RalB in colorectal cancer.

RALA RALB

3.49e-052206222790202
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

3.49e-052206219062096
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

3.49e-052206219933335
Pubmed

Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections.

FLOT2 FLOT1

3.49e-052206232814035
Pubmed

Tissue-specific expression of GTPas RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interaction.

RALA RALB

3.49e-052206211025226
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

3.49e-05220622459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

3.49e-052206217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

3.49e-052206212207352
Pubmed

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.

RALA RALB

3.49e-052206212856001
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

3.49e-052206227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

3.49e-052206222387014
Pubmed

Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population.

IRF5 TNFAIP3

3.49e-052206225337792
Pubmed

Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.

FLOT2 FLOT1

3.49e-052206211159550
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

3.49e-052206223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

3.49e-052206223918728
Pubmed

Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.

FLOT2 FLOT1

3.49e-052206219318123
Pubmed

TSH increases synthesis of hepatic ATP-binding cassette subfamily A member 1 in hypercholesterolemia.

ABCA1 TSHR

3.49e-052206227179782
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

3.49e-05220623037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

3.49e-052206211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

3.49e-05220624216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

3.49e-05220626950384
Pubmed

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

RALA RALB

3.49e-052206226216878
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

3.49e-05220628660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

3.49e-05220628428773
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

3.49e-052206224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

3.49e-052206221345967
Pubmed

Infection by Anaplasma phagocytophilum Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins.

FLOT2 FLOT1

3.49e-052206230914515
Pubmed

Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages.

TLR2 TNFAIP3

3.49e-052206231057558
Pubmed

Expression of flotillins in the human placenta: potential implications for placental transcytosis.

FLOT2 FLOT1

3.49e-052206223064789
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

3.49e-05220622572548
Pubmed

The complement component C4 of mammals.

C4A C4B

3.49e-05220622302180
Pubmed

Xanthine oxidoreductase is central to the evolution and function of the innate immune system.

FLOT2 FLOT1

3.49e-052206212967676
Pubmed

LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14).

KIF14 LETM1

3.49e-052206234605738
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

3.49e-052206222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

3.49e-052206218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

3.49e-052206229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

3.49e-05220626589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

3.49e-052206225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

3.49e-052206217728371
Pubmed

Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding.

FLOT2 FLOT1

3.49e-052206217600709
Pubmed

Structure and organization of the C4 genes.

C4A C4B

3.49e-05220626149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

3.49e-05220626149581
Pubmed

The frequency of the TRPC4AP haplotype in Alzheimer's patients.

TRPC4AP TRPC4

3.49e-052206219059308
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

3.49e-052206212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

3.49e-05220623542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

3.49e-05220622387317
Pubmed

RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.

RALA RALB

3.49e-052206222700969
Pubmed

Coding sequences of human ralA and ralB cDNAs.

RALA RALB

3.49e-05220622662142
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

3.49e-052206216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

3.49e-05220627365238
Pubmed

Evidence for chemokine-mediated coalescence of preformed flotillin hetero-oligomers in human T-cells.

FLOT2 FLOT1

3.49e-052206223012365
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

3.49e-05220627391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

3.49e-052206217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

3.49e-052206229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

3.49e-052206217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

3.49e-05220626881182
Pubmed

Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.

FLOT2 FLOT1

3.49e-052206210462713
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

3.49e-052206217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

3.49e-052206221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

3.49e-05220626978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

3.49e-052206235898513
Cytoband1p36.21

PRAMEF9 PRAMEF11 PRAMEF15 PRAMEF4

1.91e-046320641p36.21
Cytoband12q13-q14

MYO1A SMARCD1

2.97e-046206212q13-q14
GeneFamilyVolume regulated anion channel subunits

LRRC8E LRRC8C LRRC8B

3.85e-06513331158
GeneFamilyPRAME family

PRAMEF9 PRAMEF11 PRAMEF15 PRAMEF4

2.65e-05241334686
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

A2M C4A C4B

3.16e-05913331234
GeneFamilyFlotillins

FLOT2 FLOT1

5.37e-05213321114
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN2 BCR FERMT2 ARAP2 FGD2 CADPS SBF2

8.34e-042061337682
GeneFamilyEF-hand domain containing

CAPN9 TBC1D9B RYR3 PLS3 LETM1 SDF4 EFCAB7

1.19e-032191337863
GeneFamilyMyosins, class I

MYO1A MYO1B

1.46e-03813321097
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

STAG1 CENPC ANKLE2 ELOVL2 CEP170 HEG1 PTPRM KIF14 PIBF1 FERMT2 SLC27A3 ARAP2 RALA MYO1B USP6 LTN1 AKAP11 TMEM131 PARD3 ZMYM4 AQR

4.05e-0685620521M4500
CoexpressionGSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_TREG_CD4_TCELL_UP

ABCA1 DIS3L2 HEPHL1 DOCK2 TMEM14A SBF2 SMARCD1 SDF4 TNFAIP3

7.80e-061692059M8940
CoexpressionSHEN_SMARCA2_TARGETS_UP

STAG1 CENPC SSB TASOR2 CAMSAP1 PIBF1 RALB TRAPPC11 TMEM14A AKAP11 TMEM131 PCMTD2 EXOC1 SNX5

7.95e-0642920514M29
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

INPPL1 FYCO1 ALMS1 PTPRM AHR C4A C4B PLXNB1 PRAMEF11 LRRC8C SEC16B COL6A3 SLC25A42 SYNE1 TMEM14A PRAMEF15 PRAMEF4 CUBN SDF4 PCMTD2 LRRC8B EFCAB7 SNX5

2.60e-05112420523MM1070
CoexpressionGSE17721_LPS_VS_POLYIC_8H_BMDC_UP

TRPC4AP NCBP1 BTBD1 DDX54 CAMSAP1 SEC23B SYNE1 NOL11 LTN1

2.98e-052002059M3811
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

ABCA1 DAPK2 HEG1 PTPRM FERMT2 MYO1B RAB11FIP1 SNX25 PARD3 PDZD2

7.30e-0917020610e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 A2M ABCA13 RYR3 DNAH9 FOLH1 LOXHD1 SPAG17 UNC80

2.03e-0718420692cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 A2M ABCA13 RYR3 DNAH9 FOLH1 LOXHD1 SPAG17 UNC80

2.03e-0718420692b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 A2M ABCA13 RYR3 DNAH9 FOLH1 LOXHD1 SPAG17 UNC80

2.03e-071842069ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFTPH HEG1 PLCG2 ARAP2 TBXAS1 LRRC8C JADE2 SYNE1 UBR4

2.91e-0719220691ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 PLCG2 DNAH9 IQCG DNAH3 DYNC2H1 SYNE1 SPAG17 CFAP44

3.18e-0719420694a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DAPK2 ARHGEF38 PTPRM SYNE1 MYO1B SNX25 LRBA PARD3 PDZD2

3.32e-0719520699406866f99555198a9be311fbd65751b70f35446
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IFT140 ABCA13 DAPK2 DNAH3 GLB1L3 OLFM4 LCN2 UNC80

3.53e-0714320689836a040a2ebcf6f05431e658a7b8fd566621452
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IFT140 ABCA13 DAPK2 DNAH3 GLB1L3 OLFM4 LCN2 UNC80

3.53e-0714320684622c221b5d2d4cd4f37e4f81662e073924e1507
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH9 IQCG LCA5 DNAH3 DYNC2H1 SYNE1 CRACDL SPAG17 CFAP44

3.77e-071982069ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DAPK2 CAPN13 PLS3 ARAP2 MYO1B RAB11FIP1 PARD3 PDZD2

2.36e-06184206857c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DAPK2 CAPN13 PLS3 ARAP2 MYO1B RAB11FIP1 PARD3 PDZD2

2.36e-061842068d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKTN SEC16B COL6A3 DYNC2H1 LMBR1 AKAP11 PCMTD2

2.77e-0613220674152529611eeacf0c547e2a134d5b98c45426b13
ToppCellEpithelial-Epithelial-D_(Ciliated)|Epithelial / shred on cell class and cell subclass (v4)

DNAH9 IQCG LCA5 DNAH3 DYNC2H1 SYNE1 SPAG17 CFAP44

2.77e-0618820688f30535a32968a81a304315a49c0d90a77d36948
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

TASOR2 ARAP2 SMG6 PARP14 ZNF10 TMEM131 TNFAIP3 LRBA

2.77e-061882068ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D231|Adult / Lineage, Cell type, age group and donor

CAPN9 DAPK2 PLS3 ARAP2 MYO1B RAB11FIP1 PARD3 PDZD2

2.88e-0618920685a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DAPK2 CAPN13 HEG1 PLS3 MYO1B RAB11FIP1 PARD3 PDZD2

3.00e-06190206830b50d183d7649146eb1e79b47ba897355f1998a
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HK3 ABCA13 SYNE1 OLFM4 LCN2 LOXHD1 TRIB1 UNC80

3.12e-061912068d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DAPK2 ARHGEF38 PTPRM SYNE1 MYO1B SNX25 PARD3 PDZD2

3.50e-06194206853f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA1 NAIP CPED1 NRP2 DOCK2 TBXAS1 FGD2 TLR2

3.50e-0619420681dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH9 DNAH3 DYNC2H1 SYNE1 LCN2 CRACDL PARD3 SPAG17

3.64e-061952068fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

ABCA1 NAIP CEP170 DOCK2 TBXAS1 FGD2 SBF2 TLR2

3.64e-061952068c172c5599379c29123340621a36bfb1fc90c2115
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH9 DNAH3 DYNC2H1 SYNE1 LCN2 CRACDL PARD3 SPAG17

3.64e-061952068eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH9 IQCG DNAH3 DYNC2H1 SYNE1 CRACDL SPAG17 CFAP44

3.64e-0619520683486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

CAPN13 DNAH9 DNAH3 DYNC2H1 LCN2 CRACDL PARD3 SPAG17

3.64e-06195206821dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGEF38 CENPK CAPN13 XRRA1 CNDP1 ZKSCAN2 CUBN

3.72e-061382067611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH9 IQCG LCA5 DNAH3 DYNC2H1 CRACDL SPAG17 CFAP44

3.78e-06196206827b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCellCOVID-19-lung-Macrophage_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

ABCA1 HK3 NAIP DOCK2 TBXAS1 FGD2 PARP14 TLR2

3.78e-0619620681b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCellSevere_COVID-19-Epithelial-transitional_Epi|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

GABRP ABCA13 FER1L6 PLS3 PLXNB1 CLCA4 DYNC2H1 LCN2

3.92e-0619720685ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GABRP ABCA13 SPTBN2 FER1L6 CAPN13 DNAH3 LCN2 CFAP44

3.92e-0619720685c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA1 NAIP AHR DOCK2 TBXAS1 FGD2 PARP14 TLR2

3.92e-06197206810190b877bf46ba2163d203df9dd3b498c66e52f
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 DNAH9 IQCG DNAH3 DYNC2H1 SYNE1 SPAG17 CFAP44

3.92e-06197206891637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 DNAH9 IQCG DNAH3 DYNC2H1 SYNE1 SPAG17 CFAP44

3.92e-06197206822c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CAPN9 ABCA1 DAPK2 CAPN13 HEG1 ARAP2 MYO1B RAB11FIP1

3.92e-0619720688d5097898dd01cedb04cb694cb480c931e08462c
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 DNAH9 IQCG DNAH3 DYNC2H1 SYNE1 SPAG17 CFAP44

3.92e-0619720683bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M ABCA1 NAIP CEP170 AHR TBXAS1 FGD2 TLR2

3.92e-061972068e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 DNAH9 IQCG DNAH3 DYNC2H1 SYNE1 SPAG17 CFAP44

3.92e-06197206887db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

GABRP ARHGEF38 CAPN13 HEPHL1 DNAH9 DNAH3 SPAG17 CFAP44

4.07e-061982068e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

GABRP ARHGEF38 CAPN13 HEPHL1 DNAH9 DNAH3 SPAG17 CFAP44

4.07e-061982068e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

KIAA0408 CPED1 PXDNL COL6A3 DYNC2H1 SYNE1 NTNG1 ADAMTS8

4.22e-06199206830d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA1 HK3 CPED1 NRP2 DOCK2 TBXAS1 FGD2 TLR2

4.22e-0619920689545ac59c8d75f5747dff86cb511a149dc103b31
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

GABRP ARHGEF38 CAPN13 HEPHL1 DNAH9 DNAH3 SPAG17 CFAP44

4.38e-06200206872c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

GABRP ARHGEF38 CAPN13 HEPHL1 DNAH9 DNAH3 SPAG17 CFAP44

4.38e-062002068da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

KIAA0408 ABCA1 CPED1 PXDNL COL6A3 SYNE1 NTNG1 ADAMTS8

4.38e-062002068bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HK3 DOCK2 TBXAS1 SEC16B COL6A3 TLR2 TNFAIP3

6.17e-06149206734a3075af794052763fc7c4135f3031f89da5caa
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HK3 DOCK2 TBXAS1 SEC16B COL6A3 TLR2 TNFAIP3

6.17e-061492067183c77cc8f23b8406e7241a066cb684470002a3b
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HK3 DOCK2 TBXAS1 SEC16B COL6A3 TLR2 TNFAIP3

6.17e-061492067406a5ccfedbf43543f0346ff7ef3ce1d15c38f29
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HK3 DOCK2 TBXAS1 SEC16B COL6A3 TLR2 TNFAIP3

6.17e-061492067be698ecce34ddbdf57d08082b71268934675e74e
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SETD1A IFT140 FER1L6 KICS2 ZNF624 PLXNB1 EFCAB7

9.83e-061602067af84da18c85037f49f55e8958f00f12140226982
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SETD1A IFT140 FER1L6 KICS2 ZNF624 PLXNB1 EFCAB7

9.83e-061602067a76ad44b5f25f59d6b9333fb45f8bb96196a3090
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SETD1A IFT140 FER1L6 KICS2 ZNF624 PLXNB1 EFCAB7

9.83e-061602067f7ca98beaa24f9674d503588eb15d341c4135d77
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 ST8SIA6 PLCG2 CA2 OLFM4 MYO1B UBE2QL1

9.83e-06160206786fde32f096eaf9ea3677f57169cdcc0a57bb8dd
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HK3 ABCA13 TUBA4A CAPN13 SYNE1 FABP9 LCN2

1.15e-0516420672a230ea066decb798a0e6f2b96c7608c8e608031
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HK3 ABCA13 TUBA4A CAPN13 SYNE1 FABP9 LCN2

1.15e-051642067d02d39edd0bfef5a53b814ec6d5f026d41253218
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

IRF5 PLCG2 FGD2 HEATR5A THUMPD2 TNFAIP3 EFCAB7

1.25e-051662067063d68f2ffb40770cb4601fa1cb6426ae26f7a37
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

IRF5 PLCG2 FGD2 HEATR5A THUMPD2 TNFAIP3 EFCAB7

1.25e-051662067f28d07715e6b00ca2a0df39273c5f569744be5a8
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

IRF5 PLCG2 FGD2 HEATR5A THUMPD2 TNFAIP3 EFCAB7

1.25e-051662067417cfb207da08fa1a0fd5f2a13c8786628667a8e
ToppCellControl|World / group, cell type (main and fine annotations)

DAPK2 SYNE1 MYO1B RAB11FIP1 SNX25 PARD3 PDZD2

1.35e-051682067a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellfacs-GAT-Fat-18m-Myeloid-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF5 AHR PLCG2 DOCK2 TBXAS1 FGD2 RAB11FIP1

1.40e-0516920677a7416fcbffcf57d19b477d9da091e04e3499524
ToppCellfacs-GAT-Fat-18m-Myeloid|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF5 AHR PLCG2 DOCK2 TBXAS1 FGD2 RAB11FIP1

1.40e-0516920670e1a99cd77edcf32bcb513abd247b2b27409ac63
ToppCellfacs-GAT-Fat-18m-Myeloid-myeloid_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF5 AHR PLCG2 DOCK2 TBXAS1 FGD2 RAB11FIP1

1.40e-0516920679bbad31ef03078f5aa456f2e1b17b49c91545ff0
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 RYR3 C4B DNAH9 CUBN LCN2 UNC80

1.40e-05169206712bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M ABCA13 DAPK2 SYNE1 OLFM4 LCN2 TRIB1

1.57e-051722067d354424c1f861b6607dfd63b9724f4c237b30275
ToppCellfacs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IRF5 AHR PLCG2 DOCK2 TBXAS1 FGD2 RAB11FIP1

1.69e-051742067c52aed2ffe9c648e5f23e3459e2d331d6ca214e3
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAPK2 BCR RYR3 NRP2 COG6 LCA5 LCN2

1.76e-05175206709163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAPK2 BCR RYR3 NRP2 COG6 LCA5 LCN2

1.76e-0517520670801cccec6915aefc135262fc74580280fd51aa5
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAG1 ITPKB ARAP2 SYNE1 CGAS PARP14 MX2

1.96e-05178206701dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GABRP ABCA13 ARHGEF38 ANKLE2 FER1L6 PLCG2 RAB11FIP1

2.03e-0517920676e965e424eebef50f0202cff75f458be395cfca1
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN9 DAPK2 PLS3 ARAP2 MYO1B RAB11FIP1 PDZD2

2.03e-0517920674f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HK3 PLCG2 DOCK2 TBXAS1 FGD2 TLR2 TNFAIP3

2.03e-0517920675122fc794509492afde4af8b1b76d51e3070ef05
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

A2M NAIP TBXAS1 FGD2 PARP14 TNFAIP3 MX2

2.11e-0518020676f8fa9fa91cd25b92584972bb34d90c483222f52
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

A2M ABCA1 HK3 NAIP CNTLN NRP2 TLR2

2.11e-0518020677be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 DNAH9 IQCG DNAH3 DYNC2H1 SPAG17 CFAP44

2.11e-0518020671f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIS3L2 ELOVL2 KICS2 PLXNB1 LRRC8E EFCAB7 UNC80

2.26e-051822067c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAIP ARAP2 DOCK2 OLFM4 LCN2 TLR2 TNFAIP3

2.26e-051822067243c783675df495ea4112dbf710712c44ea6b4f1
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAIP ARAP2 DOCK2 OLFM4 LCN2 TLR2 TNFAIP3

2.26e-05182206718790a394dc32b3cef99cdbf826392c520e38b4a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

CAPN9 DAPK2 PLS3 ARAP2 MYO1B RAB11FIP1 PDZD2

2.43e-051842067561592edc3083fad41b91811151b442207c65dd9
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 ARHGEF38 FER1L6 NRP2 CAPN13 PLCG2 LCN2

2.43e-05184206701c19a830348ab0b9c02c1546a439de70ee10f97
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN9 DAPK2 PLS3 ARAP2 MYO1B RAB11FIP1 PDZD2

2.51e-0518520671c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCellCOPD-Myeloid-Mast|COPD / Disease state, Lineage and Cell class

A2M RYR3 HEG1 ST8SIA6 AHR FERMT2 CADPS

2.60e-051862067def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH9 LCA5 DNAH3 DYNC2H1 CRACDL SPAG17 CFAP44

2.60e-05186206776033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

STAG1 PARP4 ALMS1 HEATR5A VPS13D LTN1 TMEM131

2.60e-05186206703db813598b67b1e08f759758a1c2023396921fa
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST8SIA6 PTPRM PLS3 CUBN FRMPD3 PARD3 ECE2

2.69e-051872067d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

CAPN9 DAPK2 PLS3 ARAP2 MYO1B RAB11FIP1 PDZD2

2.69e-05187206777f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST8SIA6 PTPRM PLS3 CUBN FRMPD3 PARD3 ECE2

2.78e-051882067ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

DAPK2 ARHGEF38 MYO1B RAB11FIP1 SNX25 PARD3 PDZD2

2.78e-051882067707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Ptgfr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAM18 TRPC4 RYR3 KIF14 DNAH9 NTNG1

2.79e-051272066fb58f4b4d3722f4b9a2e4946c0244c5b70dd883b
ToppCellControl-Myeloid-Monocytes|Control / group, cell type (main and fine annotations)

HK3 DOCK2 TBXAS1 FGD2 SBF2 TLR2 MX2

2.88e-0518920673335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCellCOPD-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

A2M RYR3 ITPKB HEG1 ST8SIA6 FERMT2 CADPS

2.98e-051902067379dbac19110b76079a7a53209569e060a852acb
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABCA1 NAIP CPED1 DOCK2 TBXAS1 FGD2 TLR2

2.98e-051902067f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

ABCA13 RYR3 DNAH9 PLXNB1 DNAH3 LCN2 SPAG17

3.08e-051912067ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HK3 NAIP DOCK2 TBXAS1 FGD2 TLR2 MX2

3.08e-05191206747a2afc4102199b4bc76bd01b2967c8016186462
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NAIP TUBA1B AHR TBXAS1 FGD2 TLR2 TNFAIP3

3.08e-05191206794c7da03e5264f4d73bb507ce339a935d90279a0
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

ABCA13 RYR3 DNAH9 PLXNB1 DNAH3 LCN2 SPAG17

3.08e-0519120676228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellCiliated-cil-3|World / Class top

DNAH9 IQCG DNAH3 DYNC2H1 SYNE1 SPAG17 CFAP44

3.18e-0519220674989ebb8812b8af1870599acd932849122c05a29
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

STAG1 PTPRM CUBN SBF2 LRBA PARD3 PDZD2

3.18e-051922067e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

A2M NRP2 PTPRM CYP7B1 COL6A3 INTS12 ADAMTS8

3.18e-05192206762904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABCA13 DNAH9 DNAH3 DYNC2H1 CRACDL SPAG17 CFAP44

3.29e-051932067ea345d34440b25f65358a53dc72831998d1c3620
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 DNAH9 IQCG DNAH3 DYNC2H1 CRACDL SPAG17

3.29e-051932067e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

TASOR2 LMBR1 HEATR5A SBF2 LRRC8B ZMYM4 AQR

3.29e-051932067abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
DiseaseColorectal Carcinoma

ABCA1 HK3 ABCA13 SPTBN2 ZNF624 DNAH3 FOLH1 SYNE1 NTNG1 MYO1B CUBN OVGP1 TLR2 SDF4 SPAG17 ZMYM4

2.32e-0570219816C0009402
Diseasemuscular dystrophy (is_implicated_in)

FKTN COL6A3 SYNE1

1.89e-04171983DOID:9884 (is_implicated_in)
Diseasetotal blood protein measurement

TRPC4AP STAG1 RFX8 SMG6 DNAH3 TTC41P NPEPL1 SBF2 TMEM131 LRRC8B TRIB1

2.44e-0444919811EFO_0004536
Diseasealbuminuria

TSHR AHR CUBN SBF2 TRIB1

4.38e-04941985EFO_0004285
Diseasecerebellum growth measurement

DNAH9 TBXAS1

4.42e-0451982EFO_0009327
Diseaseurinary tract infection (is_implicated_in)

LCN2 TLR2

6.60e-0461982DOID:0080784 (is_implicated_in)
Diseaseintraocular pressure measurement

ABCA1 STAG1 FERMT2 SMG6 RALB COL6A3 TTC41P DYNC2H1 FOLH1 ADAMTS8 PTCD2

6.95e-0450919811EFO_0004695
Diseasecoronary artery disease, plasminogen activator inhibitor 1 measurement

STAG1 SMG6 DYNC2H1 TRIB1

8.60e-04631984EFO_0001645, EFO_0004792
Diseaseresponse to 5-fluorouracil, response to antineoplastic agent

ARAP2 MYO1B

9.20e-0471982GO_0036275, GO_0097327
DiseaseMalignant neoplasm of breast

GABRP TBC1D9B HK3 TRPC4 ARHGEF38 FKTN AHR DNAH9 PLS3 PLXNB1 TBXAS1 DYNC2H1 SYNE1 UBR4 CUBN SMARCD1 LRBA

9.75e-04107419817C0006142
Diseasemicrolissencephaly (implicated_via_orthology)

TUBA4A TUBA1B

1.22e-0381982DOID:0112234 (implicated_via_orthology)
Diseaselissencephaly 3 (implicated_via_orthology)

TUBA4A TUBA1B

1.22e-0381982DOID:0112232 (implicated_via_orthology)
Diseasepolymicrogyria (implicated_via_orthology)

TUBA4A TUBA1B

1.22e-0381982DOID:0080918 (implicated_via_orthology)
Diseasebitter non-alcoholic beverage consumption measurement

AHR SEC16B PCMTD2

1.28e-03321983EFO_0010093
Diseasetissue plasminogen activator measurement, coronary artery disease

STAG1 SMG6 DYNC2H1 TRIB1

1.35e-03711984EFO_0001645, EFO_0004791
DiseaseLupus Erythematosus, Systemic

IRF5 C4A C4B TNFAIP3

1.35e-03711984C0024141
Diseasecervical carcinoma

FSIP2 ALMS1 ARMH3 TBXAS1 ZKSCAN2 EXOC1

1.48e-031821986EFO_0001061
Diseaselifestyle measurement, systolic blood pressure

DAPK2 FOLH1

1.56e-0391982EFO_0006335, EFO_0010724
DiseaseAutoinflammatory disorder

PLCG2 COPA TNFAIP3

1.66e-03351983C3860213
DiseaseDNA methylation

ABCA1 ABCA13 CENPK ALMS1 PTPRM PXDNL AHR ARAP2 DNHD1 SEC16B LRRIQ3 PARD3

1.68e-0365619812GO_0006306
Diseasepulmonary function measurement, forced expiratory volume

ARHGEF38 INTS12 ZKSCAN2

1.95e-03371983EFO_0003892, EFO_0004314
DiseaseModerate albuminuria

ST8SIA6 AHR CUBN TRIB1

2.09e-03801984HP_0012594
DiseaseGraves' disease (is_implicated_in)

TSHR C4A C4B

2.28e-03391983DOID:12361 (is_implicated_in)
Diseasepolybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement

PTPRM LOXHD1

2.37e-03111982EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
DiseaseJeune thoracic dystrophy

IFT140 DYNC2H1

2.37e-03111982C0265275
Disease1-methylxanthine measurement

AHR CYP7B1

2.37e-03111982EFO_0021174
Diseasecolonic neoplasm

ITPKB FERMT2 FGD2

2.63e-03411983EFO_0004288
DiseaseAutoimmune Diseases

C4B COPA TNFAIP3

2.82e-03421983C0004364
Diseaserespiratory system disease

ITPKB COG6 RDH16 PTCD2 TNFAIP3

3.02e-031451985EFO_0000684
DiseaseShort Rib-Polydactyly Syndrome

IFT140 DYNC2H1

3.33e-03131982C0036996
Diseaseobesity (is_implicated_in)

ABCA1 INPPL1 FABP2 TH

3.34e-03911984DOID:9970 (is_implicated_in)
DiseaseIntellectual Disability

SETD1A STAG1 CA2 CNDP1 RALA SYNE1 LETM1 TH SMARCD1

3.37e-034471989C3714756
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

A2M ABCA1

3.87e-03141982DOID:10976 (biomarker_via_orthology)
DiseaseSaldino-Noonan Syndrome

IFT140 DYNC2H1

3.87e-03141982C0036069
DiseaseMajewski Syndrome

IFT140 DYNC2H1

3.87e-03141982C0024507
DiseaseAutosomal recessive limb-girdle muscular dystrophy

FKTN TRAPPC11

3.87e-03141982cv:C2931907
Diseasevital capacity

DIS3L2 SPTBN2 WARS2 AHR PIBF1 CA2 SMG6 COL6A3 TENT4B INTS12 JADE2 SYNE1 ZKSCAN2 ADAMTS8 LRBA PARD3 PDZD2

4.19e-03123619817EFO_0004312
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GABRP PLXNB1 PARD3

4.37e-03491983DOID:0060037 (implicated_via_orthology)
Diseasefacial morphology measurement

BCR CPED1 WARS2 FKTN PXDNL SMG6 GTF2A1L CRACDL UBE2QL1

4.42e-034661989EFO_0007841
DiseaseProteinuria

SMG6 CUBN

4.44e-03151982HP_0000093
Diseasetriacylglycerol 50:5 measurement

LRRC8E MYO1B

5.05e-03161982EFO_0010412
Diseasecutaneous Leishmaniasis

PXDNL PPP6R1

5.05e-03161982EFO_0005046
DiseaseDystonia, Limb

COL6A3 TH

5.70e-03171982C0751093
DiseaseDystonia, Diurnal

COL6A3 TH

5.70e-03171982C0393610
Diseasecyclic adenosine monophosphate measurement

PTPRM ARAP2

5.70e-03171982EFO_0010473
DiseaseHepatomegaly

DAPK2 AHR MYO1B

5.74e-03541983C0019209
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

STAG1 PLGRKT IRF5 COG6 AHR

5.91e-031701985EFO_0000685, EFO_0007791, EFO_0007837
Diseasegallstones

KDELR3 ARPC2 LRBA TRIB1

6.13e-031081984EFO_0004210
DiseaseDystonia, Paroxysmal

COL6A3 TH

6.39e-03181982C0393588
DiseaseRheumatoid Arthritis

IRF5 AHR LCN2 TLR2 TNFAIP3

6.51e-031741985C0003873

Protein segments in the cluster

PeptideGeneStartEntry
RVLSFFKTLNDDSVV

NAIP

1266

Q13075
SILEIRTKNFIFRTK

AHR

276

P35869
VFQFSKKIRQSIDKT

CEP170

1421

Q5SW79
KARKSIEFLEQRFES

SMG6

1306

Q86US8
STTRFIFEKKLAQAL

ANKLE2

96

Q86XL3
IFSKVDVNTDRKISA

SDF4

106

Q9BRK5
LLANEKVEEFTTFVK

CNTLN

1271

Q9NXG0
RLFETKITQVLHFTK

C4B

1641

P0C0L5
KRFTVKLQTFFETFL

CPED1

301

A4D0V7
EVKLSVKFNSREFSL

BCR

1026

P11274
FADFATFSKKERIQL

AFTPH

231

Q6ULP2
TKRFVSEARFVETLL

ADAMTS8

211

Q9UP79
KTTFNSIVKSDVDIR

POTEKP

276

Q9BYX7
IVFTTVIFKRNEISK

ADAM18

701

Q9Y3Q7
TFNREEKLFRALEKT

ARHGEF38

341

Q9NXL2
KENSATFIERKLSFE

ARHGEF38

541

Q9NXL2
SKKDRVTVVFSTVFK

ARPC2

156

O15144
NKFTVKESSAFRNIE

FABP2

46

P12104
KSSFINKVTRADVDV

GTPBP4

181

Q9BZE4
KRAFELQKSAFSEEV

FLOT2

216

Q14254
SFVVFLIQERVSKAK

ABCA1

1671

O95477
FRDISDISFIQSKKV

ALMS1

2286

Q8TCU4
SLRSIVDFTEQFLKT

ABCA13

2256

Q86UQ4
TKASVRKSFSEDVFQ

AKAP11

11

Q9UKA4
RKSFSEDVFQSVKSL

AKAP11

16

Q9UKA4
KEAAFFKELVRSIST

ARMH3

651

Q5T2E6
TSIIKFKDQDFTTLR

CAPN13

11

Q6MZZ7
ETFLFQRLENSKKRS

ARAP2

336

Q8WZ64
IKKIFTQLEEFRASE

AQR

1001

O60306
QFEKSQASEFLLSKR

DNHD1

916

Q96M86
KLDRTFAVTDELVFK

CCDC22

531

O60826
FAKRFEELQKETFTT

DHTKD1

146

Q96HY7
SKRVQELSTSLFFAV

DIS3L2

746

Q8IYB7
SIEKVVASVKRFSTF

CAMSAP1

161

Q5T5Y3
FSSNLIDKRSKEFLT

CGAS

491

Q8N884
LRTKAFSQEVFKVTF

CFAP44

266

Q96MT7
IKSIANSFDDRFLVT

CFAP44

861

Q96MT7
TITKLSFVKVDSHFR

A2M

346

P01023
SQISKVELFRSFQKL

ADAT1

431

Q9BUB4
TTETLKKIQIDRQFF

IQCG

161

Q9H095
VSTKNFSFKREDSVL

RAI2

461

Q9Y5P3
TSAKTRANVDKVFFD

RALA

156

P11233
ETSAKTRANVDKVFF

RALB

156

P11234
KQAFSDSIKRIAFLS

OR6C2

296

Q9NZP2
FFTEELVSKITRETN

PGBD4

111

Q96DM1
SQIAVFKEFLLRATK

RAD17

191

O75943
SNAVKLSRFFDKVIE

RABL3

191

Q5HYI8
ETTFLAFKRTEVKTS

INTS12

256

Q96CB8
SEKRVFNIVDRFTSK

LTN1

1586

O94822
TKARITDFQFKELVV

MOB2

31

Q70IA6
NSVIKSFTASVDRKF

NOL11

201

Q9H8H0
RLERNFTVSAVIFKK

RBL2

151

Q08999
KLTDSFTEVKVDISF

TENT4B

221

Q8NDF8
EVKLQKTSRSTDFRV

CADPS

1116

Q9ULU8
SLENIFAESKIKSFR

KIF14

1466

Q15058
ESVSASQKAIIFKRL

MAGEB6

176

Q8N7X4
VVFDSIESAKKFVET

SSB

156

P05455
VAFKSKATNDEIFSI

NCBP1

506

Q09161
TTKVEQVKLLDRFST

MTMR6

6

Q9Y217
EKNTSFRTFSKTIVK

SBF2

1031

Q86WG5
TVTVTEKFSVRFKEN

MYO1A

996

Q9UBC5
LIFDNTFSRFVSKKV

FYCO1

1446

Q9BQS8
DQTLVIKTFRFLSQK

GABBR1

576

Q9UBS5
LRTTNKSFIEAVEKY

GLB1L3

186

Q8NCI6
LVRKFTSAVREELFK

LMBR1

446

Q8WVP7
FSTISKIAERIKIFF

LIPJ

151

Q5W064
VKNFTEIASKFSERL

FOLH1

636

Q04609
SATKDFSVFFQKIRE

LETM1

281

O95202
EVLFLSSRSKVFERA

LOXHD1

846

Q8IVV2
RFAEALKDNTVVKTF

LMOD2

231

Q6P5Q4
LKTSFFLVREDTKAA

DDX54

311

Q8TDD1
NFITKTIFKRLESFA

FSIP2

2251

Q5CZC0
NSVKFITIFERSKDV

FSIP2

6836

Q5CZC0
LFVKATFDRQSKEIA

ECE2

491

P0DPD6
RTILADNDEVKFKSF

JADE2

346

Q9NQC1
KFSEQVFKVASSDLV

FLOT1

126

O75955
AKQKLDFFIRTSDSF

PCMTD2

121

Q9NV79
ESIEKARKEQSRFFI

PLGRKT

131

Q9HBL7
FQEVKSSDIAKTFRK

PLS3

81

P13797
KFVDDLFQVILSTSR

PLXNB1

1931

O43157
KFRKTFDSENDTFRL

KDELR3

81

O43731
SRRLEKKTVTVEFFL

NPEPL1

141

Q8NDH3
SFFSVKQRIKSFENL

PDZD2

2331

O15018
FLDVSFVERILKSQK

FBXO39

376

Q8N4B4
SITAVEARAFVRKFK

NRP2

511

O60462
KEIVTQFTTQFLKLR

PRAMEF15

256

P0DUQ1
EKLAAKTDEFNRTVF

KIAA0408

436

Q6ZU52
SFDRSVIVAAKKSAV

LRBA

1721

P50851
DTESELFRTKFSLQK

LCA5

191

Q86VQ0
FAVFLSEVSESRLKQ

LRRC8E

381

Q6NSJ5
RTFVTEFKLKRTFLN

HEG1

1066

Q9ULI3
EFKLKRTFLNTTVEK

HEG1

1071

Q9ULI3
IQREVKTKLFSLEHF

IRF5

361

Q13568
RSFVETKADSIIRQK

PLCG2

956

P16885
EFIFSDTHELKQKRT

PARP4

796

Q9UKK3
FVTAVLTKLRFEVFQ

HCN3

436

Q9P1Z3
RLQTRDIFKTKFLSE

HK3

781

P52790
VKQADFVRSKSFLIT

CRACDL

871

Q6NV74
SKRFSIFLSEVSENK

LRRC8B

381

Q6P9F7
HFTIVIIFESKKSER

KICS2

401

Q96MD2
IIFESKKSERDSHFI

KICS2

406

Q96MD2
TKELTSELKENFIRF

LCN2

161

P80188
TVEAFAEAVKTVFKA

PARP14

966

Q460N5
RNVTVLAKTKFSQDF

PXDNL

1351

A1KZ92
RKSLAINEEFVSIFK

COG6

81

Q9Y2V7
IRFKIDASVEKASFR

CUBN

796

O60494
VSELKEKFQSRTSEA

DYNC2H1

3141

Q8NCM8
AQVSFDKLKSARDVV

HEATR5A

891

Q86XA9
RTKRSSVVFADEKAA

DOCK2

1701

Q92608
DSTRIKLAFKTSIFS

DNAH3

171

Q8TD57
FFIERVINKISFSLA

DNAH3

2551

Q8TD57
EFLDTIFFVLRKKTS

ELOVL2

126

Q9NXB9
TKEFKSTLSDIFEVI

EFCAB7

401

A8K855
RQAKKSFSTLFLETV

CENPC

256

Q03188
SFSTLFLETVKRKSE

CENPC

261

Q03188
FSQTSELAKDFIRKL

DAPK2

251

Q9UIK4
KFEEAVEKFRSILLS

COPA

1021

P53621
LSEFSKISKIQLFRE

FRMPD3

436

Q5JV73
TKASLKERFAFLFNS

BTBD1

51

Q9H0C5
LKNKVETFSESRIFN

CENPK

146

Q9BS16
ETFSESRIFNELKTK

CENPK

151

Q9BS16
FFLKDFSTKRQIIDA

COL6A3

1691

P12111
NTVEAVAFRKSAKEL

FKTN

266

O75072
FVDATFTKRKRLSAE

HEPHL1

436

Q6MZM0
RAKFKSLTVVSTFEL

ITGA10

1076

O75578
QVFFQELLKTARSSK

FGD2

126

Q7Z6J4
FRVFSNKLLEKAFSI

CYP7B1

111

O75881
ADRTKFDKIFEQVLS

EXOC1

506

Q9NV70
NATLVITFEITFRSK

CTNS

51

O60931
QRKLQVVSDTLSFFK

DNAH9

391

Q9NYC9
VKVNFSDRVFKAVSD

FERMT2

111

Q96AC1
IAELKTEFQKRLSDF

GTF2IRD2B

826

Q6EKJ0
SKTFINLREVSDRFK

CAPN9

446

O14815
FDETTADNRKVKSTI

FABP9

71

Q0Z7S8
TEKITFFASVSRQKE

IFT140

1231

Q96RY7
RLFETKITQVLHFTK

C4A

1641

P0C0L4
SFKRKISFASIEISS

GABRP

361

O00591
LSKFVKRHVFSEEVL

PTCD2

301

Q8WV60
KEIKVTSSRRFIASF

PTPRM

231

P28827
LSTFANREKFIASVI

OVGP1

111

Q12889
KRTKQFSDASQLDFV

PARD3

831

Q8TEW0
FSDASQLDFVKTRKS

PARD3

836

Q8TEW0
TNSKIIHFEIKDRFA

NTNG1

216

Q9Y2I2
QLDTTKKLRDFFTVT

NTNG1

246

Q9Y2I2
FISRSSAFISEAEKK

FER1L6

636

Q2WGJ9
EIVQKFRKAVTDFTS

WARS2

246

Q9UGM6
KKRVSFSEQLFTEEA

RAB11FIP1

806

Q6WKZ4
FVKFTDELEQKRALT

TRNAU1AP

141

Q9NX07
VVTALVTKFTKLREF

SLC9A6

311

Q92581
VTKFTKLREFQLLET

SLC9A6

316

Q92581
QFTETFLTERDKQSK

TRPC4AP

56

Q8TEL6
RKFSSFFKSLVIELD

SMARCD1

231

Q96GM5
TLFRKIISFAVQKET

SYNE1

6646

Q8NF91
AFKAIRSFLSKLESV

SCYL1

526

Q96KG9
TAVTSKERFLKSFLE

RDH16

211

O75452
NFFVESKEISVEKSL

SNX25

341

Q9H3E2
KTREQVTEAFREFTK

ITPKB

831

P27987
LLSEKIAFKTSDFSR

FEZF1

236

A0PJY2
ESIEAIVKTASRTKF

INPPL1

751

O15357
TLEESKARQKVLFFH

ST8SIA6

286

P61647
RTKIIFQVSSKRFSA

SLC25A42

56

Q86VD7
FSLQNIFSKKVLRDS

SLC35E1

201

Q96K37
AVDFTTVKFLLQDSR

SWT1

661

Q5T5J6
RLEFTAHVLSQKFEK

OLFM4

101

Q6UX06
LKEQRSKFSFLASDT

SETD1A

496

O15047
TSLFKQTFQRIFTKD

SEC23B

381

Q15437
ERAFKVFTFESLKLS

SPAG17

596

Q6Q759
SILTESVLVNFFEKR

TBC1D9B

1206

Q66K14
ATTVFFVTRLVKKHD

BTG4

6

Q9NY30
SVSSEQVLKFRKLNF

CA2

216

P00918
ATEKRFFFKNVSILI

CLCA4

66

Q14CN2
RNSSRVEKFLFDTKE

CNDP1

321

Q96KN2
KEIVTQFTTQFLKLR

PRAMEF4

256

O60810
EFKSVADSVLFLRDK

TBXAS1

116

P24557
KESVTFKDVAIDFTL

ZNF624

51

Q9P2J8
SFSRKEAEATFKSLV

UBE2QL1

131

A1L167
DRLSFIRQSSKVKFT

UNC80

1111

Q8N2C7
AVKFVSTKFEHLERV

TRAPPC11

891

Q7Z392
LKLRKFVFSTEERTQ

TRIB1

206

Q96RU8
LFSTLKETDTRNFKF

TNFAIP3

126

P21580
QLLLDTTDKFRFFKA

SPTBN2

1901

O15020
FLRLQESLATTETFK

SLC27A3

621

Q5K4L6
KVLQSKATEDFFRNS

GTF2A1L

46

Q9UNN4
SAVEKVSIDKIRFFR

RYR3

1061

Q15413
FVFQTSRSKEEFTKL

RFX8

381

Q6ZV50
SRSKEEFTKLAASFQ

RFX8

386

Q6ZV50
TFTSAQLKELERVFA

PHOX2A

96

O14813
KEIVTQFTTQFLKLR

PRAMEF9

256

P0DUQ2
VFVDKLVSRFNLSKV

TMEM131

876

Q92545
DFTASRVIRELKFIT

TMEM131

1071

Q92545
FLHQSKLKSFESERV

PIBF1

456

Q8WXW3
VSNDKRDVKVSLFTA

TMEM14A

46

Q9Y6G1
ISKESDRTFEILEKF

TTC41P

286

Q6P2S7
TLEQRDFTTKSEKFQ

THUMPD2

171

Q9BTF0
KEIVTQFTTQFLKLR

PRAMEF11

256

O60813
KLELFTNRFKDRIVS

STAG1

366

Q8WVM7
FKKTVSSHEVFLQRL

SNX5

136

Q9Y5X3
LKFATTEAIQRTEIF

SEC16B

596

Q96JE7
TDQLVSFLRKKDDFV

PPP6R1

136

Q9UPN7
FEIKSSVSSRSIFKD

ZNF10

91

P21506
EETKTFLAILKESRF

ZKSCAN2

346

Q63HK3
ETEDKSFFVRTKNLL

TASOR2

2191

Q5VWN6
VEADLTFFNTLVRKK

PTCD1

516

O75127
AIATIKTKRSIQFVD

TUBA1B

331

P68363
FDELSKIIQKVFASR

UBR4

3811

Q5T4S7
SSFVEVESIKRHFKS

UBR4

4246

Q5T4S7
ETNSLIKKFTFRNVK

TLR2

246

O60603
IKKFTFRNVKITDES

TLR2

251

O60603
FVIFKEVSSATNALR

SNRPA

56

P09012
AERRESLKATSFEFK

XRRA1

56

Q6P2D8
IKSQKIVRFLRESFD

USP6

1091

P35125
SVFKSIRKDFSLVRE

ZMYM4

146

Q5VZL5
FKELKQDISSFRFEV

TRPC4

736

Q9UBN4
AIAAIKTKRSIQFVD

TUBA4A

331

P68366
FTKAFQRDVFILLSK

TSHR

681

P16473
ALSRAVKVFETFEAK

TH

126

P07101
LTEALSFTFVERSKQ

VPS13D

1266

Q5THJ4
FDFRGKTKVFLSIEE

L1TD1

831

Q5T7N2
KRFAVFLSEVSENKL

LRRC8C

386

Q8TDW0
VDEKLDTSFRISVFK

LRRIQ3

341

A6PVS8
FRTVEAKQEKVSTTL

MYO1B

326

O43795
RLSLAEATKKEITFF

MX2

336

P20592