Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsteroid 21-monooxygenase activity

CYP2D7 CYP2D6

1.31e-054302GO:0004509
GeneOntologyMolecularFunctionanandamide 8,9 epoxidase activity

CYP2D7 CYP2D6

1.31e-054302GO:0062187
GeneOntologyMolecularFunctionanandamide 11,12 epoxidase activity

CYP2D7 CYP2D6

1.31e-054302GO:0062188
GeneOntologyMolecularFunctionprogesterone 21-hydroxylase activity

CYP2D7 CYP2D6

1.31e-054302GO:0106309
GeneOntologyMolecularFunctionanandamide 14,15 epoxidase activity

CYP2D7 CYP2D6

3.26e-056302GO:0062189
GeneOntologyMolecularFunctionanandamide epoxidase activity

CYP2D7 CYP2D6

3.26e-056302GO:0062186
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2D7 CYP2D6

7.48e-0427302GO:0008391
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2D7 CYP2D6

1.19e-0334302GO:0008395
GeneOntologyMolecularFunctionaromatase activity

CYP2D7 CYP2D6

1.26e-0335302GO:0070330
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

CYP2D7 CYP2D6

1.64e-0340302GO:0016709
GeneOntologyMolecularFunctioniron ion binding

CYP2D7 CYP2D6 P4HA1

1.94e-03166303GO:0005506
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2D7 CYP2D6

2.46e-0349302GO:0016712
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2D7 CYP2D6 P4HA1

3.02e-03194303GO:0016705
GeneOntologyMolecularFunctioncoreceptor activity

CD22 RECK

5.22e-0372302GO:0015026
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC7A4 TMEM94 SLC2A11 PIEZO1 SLC4A11 SLC35D3

7.34e-031180306GO:0022857
GeneOntologyBiologicalProcessserotonin biosynthetic process from tryptophan

CYP2D7 CYP2D6

6.13e-063302GO:0006587
GeneOntologyBiologicalProcessserotonin biosynthetic process

CYP2D7 CYP2D6

5.70e-058302GO:0042427
GeneOntologyBiologicalProcessindole-containing compound biosynthetic process

CYP2D7 CYP2D6

9.14e-0510302GO:0042435
GeneOntologyBiologicalProcessprimary amino compound biosynthetic process

CYP2D7 CYP2D6

9.14e-0510302GO:1901162
GeneOntologyBiologicalProcessoxidative demethylation

CYP2D7 CYP2D6

1.34e-0412302GO:0070989
GeneOntologyBiologicalProcesstryptophan metabolic process

CYP2D7 CYP2D6

1.84e-0414302GO:0006568
GeneOntologyBiologicalProcessindolalkylamine metabolic process

CYP2D7 CYP2D6

2.42e-0416302GO:0006586
GeneOntologyBiologicalProcessdopamine biosynthetic process

CYP2D7 CYP2D6

2.74e-0417302GO:0042416
GeneOntologyBiologicalProcessserotonin metabolic process

CYP2D7 CYP2D6

3.08e-0418302GO:0042428
GeneOntologyBiologicalProcessdolichol-linked oligosaccharide biosynthetic process

ALG10 DOLK

4.64e-0422302GO:0006488
GeneOntologyBiologicalProcessprimary amino compound metabolic process

CYP2D7 CYP2D6

5.08e-0423302GO:1901160
GeneOntologyBiologicalProcessdemethylation

CYP2D7 CYP2D6

5.53e-0424302GO:0070988
GeneOntologyBiologicalProcessdolichol metabolic process

ALG10 DOLK

5.53e-0424302GO:0019348
GeneOntologyBiologicalProcesscatecholamine biosynthetic process

CYP2D7 CYP2D6

8.10e-0429302GO:0042423
GeneOntologyBiologicalProcesscatechol-containing compound biosynthetic process

CYP2D7 CYP2D6

8.10e-0429302GO:0009713
GeneOntologyBiologicalProcesspolyprenol metabolic process

ALG10 DOLK

8.10e-0429302GO:0016093
GeneOntologyBiologicalProcessindole-containing compound metabolic process

CYP2D7 CYP2D6

9.26e-0431302GO:0042430
GeneOntologyBiologicalProcessammonium ion metabolic process

CYP2D7 CYP2D6

9.87e-0432302GO:0097164
GeneOntologyBiologicalProcessisoprenoid metabolic process

CYP2D6 ALG10 DOLK

1.18e-03144303GO:0006720
GeneOntologyBiologicalProcessxenobiotic catabolic process

CYP2D7 CYP2D6

1.32e-0337302GO:0042178
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

CYP2D7 CYP2D6

1.95e-0345302GO:0008207
GeneOntologyBiologicalProcessaromatic amino acid metabolic process

CYP2D7 CYP2D6

2.03e-0346302GO:0009072
GeneOntologyBiologicalProcessbiogenic amine biosynthetic process

CYP2D7 CYP2D6

2.12e-0347302GO:0042401
GeneOntologyBiologicalProcessorganic hydroxy compound metabolic process

DISP3 CYP2D7 CYP2D6 ALG10 DOLK

2.13e-03641305GO:1901615
GeneOntologyBiologicalProcessamine biosynthetic process

CYP2D7 CYP2D6

2.21e-0348302GO:0009309
GeneOntologyBiologicalProcessdopamine metabolic process

CYP2D7 CYP2D6

2.69e-0353302GO:0042417
GeneOntologyBiologicalProcessalcohol metabolic process

DISP3 CYP2D6 ALG10 DOLK

2.85e-03412304GO:0006066
GeneOntologyBiologicalProcessphenol-containing compound biosynthetic process

CYP2D7 CYP2D6

3.11e-0357302GO:0046189
GeneOntologyCellularComponentendoplasmic reticulum membrane

DISP3 CYP2D6 ORMDL2 TMEM94 PIEZO1 SLC35D3 ALG10 DOLK CNIH1 RETREG1

7.60e-0612933010GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

DISP3 CYP2D6 ORMDL2 TMEM94 PIEZO1 SLC35D3 ALG10 DOLK CNIH1 RETREG1

7.91e-0612993010GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

DISP3 CYP2D6 ORMDL2 TMEM94 PIEZO1 SLC35D3 ALG10 DOLK CNIH1 RETREG1

9.56e-0613273010GO:0042175
HumanPhenoPulmonary venous hypertension

FLNC PIEZO1

7.73e-05982HP:0030950
HumanPhenoInterstitial cardiac fibrosis

FLNC DOLK

9.65e-051082HP:0031329
MousePhenoabnormal limb bud morphology

P4HA1 RECK PIEZO1 ALG10

1.35e-0591234MP:0005650
MousePhenoabnormal limb development

P4HA1 RECK PIEZO1 ALG10

7.36e-05140234MP:0006279
MousePhenodecreased urine calcium level

GPR4 SLC4A11

1.16e-0410232MP:0002986
MousePhenoabnormal urine osmolality

GPR4 SLC4A11 APLNR

1.59e-0465233MP:0002987
MousePhenoabnormal cardiovascular development

GPR4 FLNC TMEM94 RECK PIEZO1 ALG10 APLNR

2.17e-04802237MP:0002925
MousePhenoabnormal prenatal body size

FLNC CSE1L P4HA1 TMEM94 RECK PIEZO1 ALG10 DOLK

2.66e-041116238MP:0010866
MousePhenoabnormal skin morphology

LRIG3 GPR4 CYP2D7 CYP2D6 PRG4 P4HA1 PIEZO1 IL17C ALG10

2.94e-041455239MP:0002060
Domain-

LRIG3 FLNC CD300LF CD22

1.64e-026632842.60.40.10
DomainGPCR_Rhodpsn_7TM

GPR4 OR9A4 OR52L1 APLNR

1.69e-02670284IPR017452
Domain7tm_1

GPR4 OR9A4 OR52L1 APLNR

1.75e-02677284PF00001
DomainG_PROTEIN_RECEP_F1_1

GPR4 OR9A4 OR52L1 APLNR

1.82e-02685284PS00237
DomainG_PROTEIN_RECEP_F1_2

GPR4 OR9A4 OR52L1 APLNR

1.88e-02691284PS50262
DomainGPCR_Rhodpsn

GPR4 OR9A4 OR52L1 APLNR

1.89e-02692284IPR000276
DomainIg-like_fold

LRIG3 FLNC CD300LF CD22

2.01e-02706284IPR013783
DomainIg_sub

LRIG3 CD300LF CD22

2.45e-02421283IPR003599
DomainIG

LRIG3 CD300LF CD22

2.45e-02421283SM00409
PathwayREACTOME_CYP2E1_REACTIONS

CYP2D7 CYP2D6

1.38e-0412212MM14847
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2D7 CYP2D6

1.38e-0412212MM15616
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP2D7 CYP2D6

3.19e-0418212MM14843
PathwayREACTOME_FATTY_ACIDS

CYP2D7 CYP2D6

3.19e-0418212MM14841
PathwayREACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS

CYP2D7 CYP2D6

4.80e-0422212MM15614
PathwayREACTOME_XENOBIOTICS

CYP2D7 CYP2D6

6.21e-0425212MM14846
PathwayREACTOME_ASPIRIN_ADME

CYP2D7 CYP2D6

2.01e-0345212MM15694
Pubmed

Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.

CYP2D7 CYP2D6

7.19e-07230211032406
Pubmed

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

CYP2D7 CYP2D6

7.19e-0723023123997
Pubmed

The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.

CYP2D7 CYP2D6

7.19e-07230219594327
Pubmed

Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.

CYP2D7 CYP2D6

7.19e-07230226297049
Pubmed

Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.

CYP2D7 CYP2D6

7.19e-07230225808902
Pubmed

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

CYP2D7 CYP2D6

7.19e-07230211207030
Pubmed

A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

CYP2D7 CYP2D6

7.19e-07230215051713
Pubmed

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

CYP2D7 CYP2D6

2.16e-0633022574001
Pubmed

Identification of the primary gene defect at the cytochrome P450 CYP2D locus.

CYP2D7 CYP2D6

2.16e-0633021978251
Pubmed

Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.

CYP2D7 CYP2D6

1.08e-05630212171760
Pubmed

Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.

CYP2D7 CYP2D6

1.51e-05730230944282
Pubmed

Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.

SAAL1 CSE1L

2.31e-042630223181366
Pubmed

Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.

FLNC CSE1L P4HA1

2.99e-0415130318457437
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FRY FBXO10 PRG4 P4HA1 OR52L1

3.85e-0473630529676528
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

LRIG3 IL17C DOLK CNIH1

6.30e-0446030420562862
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP2D7 CYP2D6

6.65e-044430212745259
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

LRIG3 FLNC CD22

8.25e-0421430322199357
InteractionENPP3 interactions

SAAL1 CSE1L

6.19e-059272int:ENPP3
InteractionCRELD1 interactions

ORMDL2 PIEZO1 ALG10 DOLK

6.26e-05163274int:CRELD1
Cytoband17q25.1

CD300LF TMEM94

1.30e-038130217q25.1
CytobandEnsembl 112 genes in cytogenetic band chr16q24

PIEZO1 IL17C

3.59e-03136302chr16q24
CytobandEnsembl 112 genes in cytogenetic band chr9p13

FBXO10 RECK

5.79e-03174302chr9p13
GeneFamilySolute carriers

SLC7A4 SLC2A11 SLC4A11 SLC35D3

4.26e-04395174752
GeneFamilyCytochrome P450 family 2

CYP2D7 CYP2D6

4.86e-04351721001
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CYP2D6 CD300LF ORMDL2

8.83e-05129303e7a15f98c3e6e4ee317e21958be3e413e3acd101
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FRY SLC4A11 RETREG1

1.52e-0415530390e629681a72baacc7981b82883866a487638dbc
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

FBXO10 IL17C ALG10

1.52e-041553037aba8ef53c9170ad8ed955c904c8991097ab1e32
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CD22 TMEM94 RETREG1

1.52e-041553030a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXO10 RECK RETREG1

1.80e-04164303b77995958c938e10a526118f75d78cee72e0b207
ToppCell3'_v3-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

FBXO10 CD22 SLC2A11

1.80e-041643037766900740f67dbbe3c4d90fbfdcc1665cee6515
ToppCellControl-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

FLNC SLC7A4 PRG4

1.86e-0416630332ebaefa6c074b28193fff764ee7c2c0e9357e20
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

FLNC SLC7A4 PRG4

1.86e-041663031ed3788257e14f097862b999f020bfe2a57de52b
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLNC SLC7A4 PRG4

2.25e-041773030912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR4 FLNC SLC4A11

2.29e-041783034b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCellASK440-Epithelial-Transformed_epithelium|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

FLNC PRG4 ALG10

2.29e-0417830386f1741636ed3e85bb4a65f84949b718fc38c290
ToppCellCOVID-19-kidney-Epi_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

FRY IL17C SLC4A11

2.32e-04179303e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CSE1L TMEM94 DOLK

2.44e-04182303c98da2db197b1531204e116600ff51891e5c17af
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRY SLC4A11 RETREG1

2.56e-04185303b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

FLNC SLC7A4 PRG4

2.56e-0418530323579988036fc1925992c31919750f9b3fe9f790
ToppCellfacs-GAT-Fat-24m-Endothelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.77e-04190303da2fcd4a2cc6e45c8174109d892f1424e39919a1
ToppCellfacs-GAT-Fat-24m-Endothelial-endothelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.77e-04190303e584eaccbc22aa7f7a4340ed8a2a8b45ddca93f4
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.77e-0419030389d1d686cc683206534e2157554d7d0df5d53497
ToppCellfacs-GAT-Fat-24m-Endothelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.77e-041903033395b2ff6ffadf84cdb1b5a37a5b6be05b56c30f
ToppCellfacs-Pancreas-Exocrine-3m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 PIEZO1 APLNR

2.77e-04190303b7fc451e160e31dc898b122de844b501f587db67
ToppCellfacs-Pancreas-Exocrine-3m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 PIEZO1 APLNR

2.77e-0419030383cc851fb9f644b17a8ebf4d99a646003769a22f
ToppCellfacs-Pancreas-Exocrine-3m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 PIEZO1 APLNR

2.77e-041903035f440d4b334d66d419c03bd828f7d93f16c1ce67
ToppCellfacs-Heart-RV-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.77e-0419030365ba6c4f4a2905c0bf4ff99518ae49e3dfd5e640
ToppCellfacs-SCAT-Fat-3m-Endothelial-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.81e-04191303a0018f88f7132477cc467ee15db029a585290595
ToppCellfacs-Heart-LA-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.81e-04191303827be47d3574c6c5b021c6f1c1670834344f10cb
ToppCellfacs-SCAT-Fat-3m-Endothelial-endothelial_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.81e-041913036b9bbf4a63d4e9a8075bb06c2aa644fcf4ee88b8
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.81e-04191303a15f0fb4bd7dd77ef5f931b6fc9d68697deec1d1
ToppCell10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRIG3 GPR4 APLNR

2.81e-04191303dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCellfacs-SCAT-Fat-3m-Endothelial|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.81e-0419130390f0c193dce267a4f1a9b2501f636dafd0a34cf7
ToppCell11.5-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

SLC7A4 SLC35D3 RETREG1

2.81e-04191303c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCellfacs-Heart-RV-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.81e-0419130384ebb9f8e975acc88aa600c08a8aa791256948a6
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SLC7A4 SLC35D3 RETREG1

2.81e-0419130319832ddd559a353e1618fe853d79e3edfec6dcda
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLC7A4 SLC35D3 RETREG1

2.85e-041923034d3a1c267739b1479217144656986972fc86db43
ToppCellwk_08-11-Mesenchymal-Mesothelial-intermediate_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC7A4 CD22 PRG4

2.85e-04192303ac9e5288ecd4b1e142f2e15a1fcd11c8eb9e15cd
ToppCellfacs-Heart-RA-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

2.99e-04195303f4fdcc0b851392086e9618e76ee6a0b540d5fb3c
ToppCell367C-Endothelial_cells-Endothelial-E|367C / Donor, Lineage, Cell class and subclass (all cells)

GPR4 FRY APLNR

2.99e-041953033b79e6bb525b17192ecec9e1227a29c419968144
ToppCell367C-Endothelial_cells-Endothelial-E-|367C / Donor, Lineage, Cell class and subclass (all cells)

GPR4 FRY APLNR

2.99e-0419530365fc50e3818e902028fc4226070fa57609c66b9c
ToppCellMesenchymal_cells-Fibro/Chondro_p.|Mesenchymal_cells / Lineage and Cell class

PRG4 P4HA1 RETREG1

2.99e-04195303b95a631d54c6cf85e48e1e638703206aaaebc073
ToppCellEndothelial|World / shred by cell class for bronchial biopsy

GPR4 FRY APLNR

2.99e-04195303f0e46e859f7a9bdead3203889f7e20fa21f76ff0
ToppCellfacs-GAT-Fat-3m-Endothelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

3.03e-04196303b6cc1f466d45479764080d34b1daeb8243a5a9f3
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRIG3 FLNC PRG4

3.03e-04196303ee45e4de9d706ec87094e87f47d3e514539b8092
ToppCellfacs-GAT-Fat-3m-Endothelial-endothelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

3.03e-04196303ede6104cdfa4ee5287efcca9bbc36677cbf7a8d8
ToppCellfacs-GAT-Fat-3m-Endothelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR4 FRY APLNR

3.03e-04196303039044ab28c53391c34d8226fb8cf78549e63ef4
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRIG3 FLNC PRG4

3.03e-04196303fa4a85a3cd52df0da5dfedc0e584e9df8c61ce89
ToppCelltumor_Lung-Endothelial_cells|tumor_Lung / Location, Cell class and cell subclass

GPR4 FRY APLNR

3.08e-041973036870b311c54a73723768276a58456620f5217d43
ToppCell(6)_Endothelial-A_(Artery)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

GPR4 FRY APLNR

3.12e-0419830344f8cd5afa3685dcc8bfea0b15af5e8817e12e2e
ToppCellBiopsy_Other_PF-Mesenchymal-Mesothelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

FLNC SLC7A4 PRG4

3.12e-0419830386736f01e61bf4961f060b24ee1f1f48340737dd
ToppCelltumor_Lung-Endothelial_cells-Tumor_ECs|tumor_Lung / Location, Cell class and cell subclass

GPR4 FRY APLNR

3.12e-041983035228c4bf2513186140c2c4eaa67a268c732bdc84
ToppCell(2)_Fibroblasts-(23)_Fibro-4|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

LRIG3 FRY PRG4

3.12e-04198303e0ef49ec0f87cc87b45efa297b9ff6c35b7a2ba9
ToppCellmetastatic_Brain-Endothelial_cells-Tumor_ECs|metastatic_Brain / Location, Cell class and cell subclass

GPR4 FRY APLNR

3.12e-041983035e274f29cc796dae7d64d6035e904816c25f9914
ToppCellmetastatic_Brain-Endothelial_cells|metastatic_Brain / Location, Cell class and cell subclass

GPR4 FRY APLNR

3.12e-0419830397ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell367C-Endothelial_cells|367C / Donor, Lineage, Cell class and subclass (all cells)

GPR4 FRY APLNR

3.17e-04199303636ff80938907f137e955388797072ab45289062
Drug3-methoxyphenethylamine

CYP2D7 CYP2D6

1.68e-062302CID000074866
Drugcupreidine

CYP2D7 CYP2D6

1.68e-062302CID000051196
Drugchlorpromazine N-oxide

CYP2D7 CYP2D6

5.03e-063302CID000443037
Drug2,4,6-trimethylbenzaldoxime

CYP2D7 CYP2D6

5.03e-063302CID000283782
DrugO-demethyl encainide

CYP2D7 CYP2D6

5.03e-063302CID000054736
Drug1-(1-phenylcyclohexyl)-4-piperidinol

CYP2D7 CYP2D6

1.01e-054302CID000098840
Drug4,4'-difluorobenzophenone

CYP2D7 CYP2D6

1.01e-054302CID000009582
Drugdesethylaprindine

CYP2D7 CYP2D6

1.01e-054302CID000162697
DrugZ-10

CYP2D7 CYP2D6

1.01e-054302CID000477529
Drugbisoprolol

CYP2D7 CYP2D6 APLNR

1.56e-0537303CID000002405
Drugeptapirone

CYP2D7 CYP2D6

1.67e-055302CID000208928
Drug2Cmp

CYP2D7 CYP2D6

1.67e-055302CID000023392
DrugKoe 1801

CYP2D7 CYP2D6

1.67e-055302CID000129632
DrugL-754,394

CYP2D7 CYP2D6

1.67e-055302CID005481990
Drugoxosparteine

CYP2D7 CYP2D6

1.67e-055302CID000097492
Drugthreohydrobupropion

CYP2D7 CYP2D6

1.67e-055302CID000000445
Drug4-hydroxyochratoxin A

CYP2D7 CYP2D6

1.67e-055302CID000114713
Drugfenproporex

CYP2D7 CYP2D6

1.67e-055302CID000061810
Drug8-Methylxanthine

CYP2D7 CYP2D6

2.51e-056302CID000087061
DrugAC1L45F6

CYP2D7 CYP2D6

2.51e-056302CID000150982
Drugnitroguanidine

CYP2D7 CYP2D6

2.51e-056302CID000011174
Drug10-hydroxyochratoxin A

CYP2D7 CYP2D6

2.51e-056302CID000135115
DrugKRM1674

CYP2D7 CYP2D6

2.51e-056302CID000126235
Drug5-dehydrosparteine

CYP2D7 CYP2D6

2.51e-056302CID000160614
Drug7-hydroxychlorpromazine

CYP2D7 CYP2D6

2.51e-056302CID000016414
DrugAC1NV8O5

CYP2D7 CYP2D6 IL17C

2.82e-0545303CID005473386
DrugRI-331

CYP2D7 CYP2D6 P4HA1

3.22e-0547303CID000160754
Drugquinidine-N-oxide

CYP2D7 CYP2D6

3.51e-057302CID000050979
DrugBen 101

CYP2D7 CYP2D6

3.51e-057302CID000090766
Drug2-sulfamoylacetylphenol

CYP2D7 CYP2D6

3.51e-057302CID000194588
Drugphenyl isocyanide

CYP2D7 CYP2D6

3.51e-057302CID000013606
Drugazoprocarbazine

CYP2D7 CYP2D6

3.51e-057302CID000075230
DrugICI-199,441

CYP2D7 CYP2D6

3.51e-057302CID003082717
Drug5,6-Dehydro-sparteine

CYP2D7 CYP2D6

3.51e-057302CID000523578
Drug2D7

CYP2D7 CYP2D6 APLNR

3.65e-0549303CID005327103
Drughydroxynortriptyline

CYP2D7 CYP2D6

4.68e-058302CID005352542
DrugMPBP

CYP2D7 CYP2D6

4.68e-058302CID000129775
Drugpirprofen

CYP2D7 CYP2D6

4.68e-058302CID000035935
Drugphenmetrazine

CYP2D7 CYP2D6

4.68e-058302CID000004762
DrugL-754394

CYP2D7 CYP2D6

4.68e-058302CID000153982
DrugB.W.306U

CYP2D7 CYP2D6

4.68e-058302CID000000446
DrugZ H-H

CYP2D7 CYP2D6

4.68e-058302CID000004657
DrugAC1L9DBW

CYP2D7 CYP2D6

4.68e-058302CID000442742
Drug3,4-dihydroxymethamphetamine

CYP2D7 CYP2D6

4.68e-058302CID000161126
DrugHCBz

CYP2D7 CYP2D6

4.68e-058302CID000196604
Drugbeta-site

CYP2D7 CYP2D6

4.68e-058302CID000003914
DrugMethamphetamine

LRIG3 GPR4 FLNC CYP2D6 PRG4 P4HA1 TMEM94 APLNR DOLK

5.42e-051401309ctd:D008694
Drughydroquinidine hydrochloride

CYP2D7 CYP2D6

6.01e-059302CID000003649
Drugp-hydroxymexiletine

CYP2D7 CYP2D6

6.01e-059302CID000093286
DrugO-demethylmetoprolol

CYP2D7 CYP2D6

6.01e-059302CID000162181
Drugguanoxan

CYP2D7 CYP2D6

6.01e-059302CID000016564
Drug1-chlorobutane

CYP2D7 CYP2D6

6.01e-059302CID000008005
DrugCP-101,606

CYP2D7 CYP2D6

6.01e-059302CID000219101
DrugAC1O3M98

CYP2D7 CYP2D6

6.01e-059302CID006332100
Drugnorethylmorphine

CYP2D7 CYP2D6

6.01e-059302CID005464196
Drugnorchlorpromazine

CYP2D7 CYP2D6

7.50e-0510302CID000062875
DrugAC1LCF1O

CYP2D7 CYP2D6

7.50e-0510302CID000627285
DrugAC1L1IDP

CYP2D7 CYP2D6

7.50e-0510302CID000004535
Drugbenzaldehyde oxime

CYP2D7 CYP2D6

7.50e-0510302CID000012143
Drug2-hydroxydesipramine

CYP2D7 CYP2D6

7.50e-0510302CID000121249
Drug4-hydroxydebrisoquine

CYP2D7 CYP2D6

7.50e-0510302CID000107669
Drug9-benzyladenine

CYP2D7 CYP2D6

9.16e-0511302CID000020262
Drugnaphthohydroquinone

CYP2D7 CYP2D6

9.16e-0511302CID000011305
Drug8-hydroxycarteolol

CYP2D7 CYP2D6

9.16e-0511302CID000124688
Drugvindoline

CYP2D7 CYP2D6

9.16e-0511302CID000016596
Drug4-hydroxy-3-methoxymethamphetamine

CYP2D7 CYP2D6

9.16e-0511302CID003081137
Drugsphondin

CYP2D7 CYP2D6

9.16e-0511302CID000108104
Drugmethoxyphenamine

CYP2D7 CYP2D6

1.10e-0412302CID000004117
DrugD02861

CYP2D7 CYP2D6

1.10e-0412302CID011954281
Drugphenylacetone

CYP2D7 CYP2D6

1.10e-0412302CID000007678
Drug16 alpha-hydroxytestosterone

CYP2D7 CYP2D6

1.10e-0412302CID000065545
Drug2-Tbmbfd

CYP2D7 CYP2D6

1.10e-0412302CID000126928
DrugDoxycycline hydrochloride [10592-13-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A

CSE1L TMEM94 SLC2A11 RETREG1

1.11e-041913047195_UP
Drugchloral

CYP2D7 CYP2D6 IL17C

1.21e-0473303CID000006407
DrugGlycopyrrolate [596-51-0]; Down 200; 10uM; PC3; HT_HG-U133A

GPR4 CD22 RECK RETREG1

1.27e-041983043687_DN
Drugchlorpromazine hydrochloride; Down 200; 1uM; HL60; HT_HG-U133A

FRY RECK PIEZO1 RETREG1

1.27e-041983041158_DN
DrugAC1L1N5A

CYP2D7 CYP2D6

1.30e-0413302CID000006717
DrugSordinol

CYP2D7 CYP2D6

1.30e-0413302CID000012453
Drugbergaptol

CYP2D7 CYP2D6

1.30e-0413302CID005280371
DrugAC1L1JL9

CYP2D7 CYP2D6

1.30e-0413302CID000005091
DrugAC1L18GM

CYP2D7 CYP2D6

1.30e-0413302CID000000092
Drug3-hydroxylidocaine

CYP2D7 CYP2D6

1.51e-0414302CID000161824
Drugsesamol

CYP2D7 CYP2D6

1.51e-0414302CID000068289
Drugthiethylperazine

CYP2D7 CYP2D6

1.74e-0415302CID000005440
Drug4-hydroxymephenytoin

CYP2D7 CYP2D6

1.74e-0415302CID000119507
DrugN-desethyloxybutynin

CYP2D7 CYP2D6

1.74e-0415302CID000133577
Drugisopimpinellin

CYP2D7 CYP2D6

1.74e-0415302CID000068079
Drugaflatoxin Q1

CYP2D7 CYP2D6

1.74e-0415302CID000104757
DrugAC1L524X

CYP2D7 CYP2D6

1.74e-0415302CID000168572
Drugpentafluorobenzoyl chloride

CYP2D7 CYP2D6

1.99e-0416302CID000075256
Drugcibenzoline

CYP2D7 CYP2D6

1.99e-0416302CID000002747
Drugalpha-hydroxymetoprolol

CYP2D7 CYP2D6

1.99e-0416302CID000114962
Drug2ccu

CYP2D7 CYP2D6

1.99e-0416302CID006102789
Drughydroxynefazodone

CYP2D7 CYP2D6

2.25e-0417302CID000127096
Drugnoralfentanil

CYP2D7 CYP2D6

2.25e-0417302CID000162172
Drugbunitrolol

CYP2D7 CYP2D6

2.25e-0417302CID000002473
DrugN-desisopropylpropranolol

CYP2D7 CYP2D6

2.25e-0417302CID000159899
Drug10-undecynoic acid

CYP2D7 CYP2D6

2.25e-0417302CID000031039
Drugchlorpromazine sulfoxide

CYP2D7 CYP2D6

2.53e-0418302CID000070413
DrugNSC404353

CYP2D7 CYP2D6

2.53e-0418302CID000273032
Diseasesolanidine measurement

CYP2D7 CYP2D6

4.83e-064272EFO_0800966
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor

CYP2D7 CYP2D6

2.20e-0424272EFO_0003761, EFO_0005658
Diseaseosteoarthritis, hip

LRIG3 PIEZO1

3.21e-0392272EFO_1000786

Protein segments in the cluster

PeptideGeneStartEntry
LVTMPAALGLWSLYL

DISP3

606

Q9P2K9
LPLELWRMILAYLHL

FBXO10

6

Q9UK96
PHWGYILLLLLTSVM

SLC7A4

506

O43246
LPLSLGLALHLLWTY

RECK

956

O95980
LVKTLYMLGSLLHWP

APLNR

266

P35414
GIWLAYIILVGLLHM

ORMDL2

21

Q53FV1
LTHIYLLLGMSLPIW

DOLK

406

Q9UPQ8
GWLYGLLMLQELHLS

LRIG3

281

Q6UXM1
LGLIWTLILHYSISM

FLNC

131

Q14315
MTLLPGLLFLTWLHT

IL17C

1

Q9P0M4
LFPWALMLLSYRGIL

GPR4

191

P46093
MIWYILIIGILLPQS

P4HA1

1

P13674
HLVLLMWSLIVSLYP

SLC2A11

61

Q9BYW1
STTLAWGLLLMILHP

CYP2D6

311

P10635
MPLLTLYLLLFWLSG

CD300LF

1

Q8TDQ1
NGRQIMLTYLLPWLH

FRY

1351

Q5TBA9
MLTYLLPWLHNIELV

FRY

1356

Q5TBA9
PEWLDVYMHILQLLT

SAAL1

261

Q96ER3
MHLLGPWLLLLVLEY

CD22

1

P20273
HVLLATWYLLMPPAL

OR52L1

291

Q8NGH7
LTLWSLRGLSLPMYV

SLC35D3

91

Q5M8T2
SLLIMLGTLWLGYTL

SLC4A11

561

Q8NBS3
LTPWRVYHLISVMIL

RETREG1

111

Q9H6L5
MAWKTLPIYLLLLLS

PRG4

1

Q92954
LWGLLLPGMQTIYLS

OR9A4

81

Q8NGU2
NLSMLLLLTWPYILL

ALG10

246

Q5BKT4
EWLTLGLNMPLLAYH

CNIH1

71

O95406
STTLAWGLLLMILHL

CYP2D7

311

A0A087X1C5
SYMALFPHLLQPVLW

CSE1L

681

P55060
HWPGASLMLLAVLLL

TMEM94

66

Q12767
MEPHVLGAVLYWLLL

PIEZO1

1

Q92508