Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

PEDS1 FADS3

2.71e-0413382GO:0016717
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF737 NLRC5 ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 KDM6B ZNF875 ZNF347

2.99e-0414593810GO:0000977
Domain-

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

1.19e-0667940103.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

1.45e-066944010IPR013087
DomainZINC_FINGER_C2H2_2

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

3.90e-067754010PS50157
DomainZINC_FINGER_C2H2_1

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

3.99e-067774010PS00028
DomainZnf_C2H2-like

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

4.95e-067964010IPR015880
DomainZnf_C2H2

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

5.47e-068054010IPR007087
DomainZnF_C2H2

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

5.65e-068084010SM00355
DomainKRAB

ZNF737 ZNF480 ZNF75A ZNF57 ZNF606 ZNF875 ZNF347

9.70e-06358407PS50805
DomainKRAB

ZNF737 ZNF480 ZNF75A ZNF57 ZNF606 ZNF875 ZNF347

9.70e-06358407PF01352
DomainKRAB

ZNF737 ZNF480 ZNF75A ZNF57 ZNF606 ZNF875 ZNF347

1.18e-05369407SM00349
DomainKRAB

ZNF737 ZNF480 ZNF75A ZNF57 ZNF606 ZNF875 ZNF347

1.20e-05370407IPR001909
Domainzf-C2H2

ZNF737 ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

1.23e-05693409PF00096
DomainTLV_coat

ERVV-1 ERVV-2

9.33e-057402PF00429
DomainTLV/ENV_coat_polyprotein

ERVV-1 ERVV-2

1.24e-048402IPR018154
DomainCYTOCHROME_B5_2

FADS3 HERC2

3.44e-0413402PS50255
DomainCYTOCHROME_B5_1

FADS3 HERC2

3.44e-0413402PS00191
DomainCyt-b5

FADS3 HERC2

4.00e-0414402PF00173
DomainCyt_B5-like_heme/steroid-bd

FADS3 HERC2

4.00e-0414402IPR001199
DomainCyt-b5

FADS3 HERC2

4.00e-0414402SM01117
Domain-

FADS3 HERC2

4.00e-04144023.10.120.10
DomainWD40_repeat

HERC2 MLST8 WDR17 FBXW12

2.66e-03272404IPR001680
DomainWD_REPEATS_1

HERC2 MLST8 WDR17 FBXW12

2.88e-03278404PS00678
DomainWD_REPEATS_2

HERC2 MLST8 WDR17 FBXW12

2.92e-03279404PS50082
DomainWD_REPEATS_REGION

HERC2 MLST8 WDR17 FBXW12

2.92e-03279404PS50294
Domainzf-C2H2_6

ZNF737 ZNF480 ZNF75A ZNF606

4.45e-03314404PF13912
DomainQuinoprotein_ADH-like_supfam

MLST8 WDR17

5.75e-0353402IPR011047
Pubmed

Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.

ERVV-1 ERVV-2

1.29e-06240223555306
Pubmed

Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.

ERVV-1 ERVV-2

1.29e-06240218826608
Pubmed

Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians.

NLRC5 ZNF875

3.87e-06340229394898
Pubmed

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.

ERVV-1 ERVV-2

1.93e-05640223085571
Pubmed

Syncytins expressed in human placental trophoblast.

ERVV-1 ERVV-2

3.60e-05840233504453
Pubmed

A whole genome screen for HIV restriction factors.

NLRC5 FADS3 MARCHF8

2.65e-0410840322082156
Pubmed

HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.

HERC2 EIF3M

5.87e-043140230279242
Pubmed

A Y2H-seq approach defines the human protein methyltransferase interactome.

ZNF480 ZNF57 NECAB2 MLST8

6.35e-0434240423455924
Pubmed

Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.

SLC6A6 NECAB2

7.07e-043440233500475
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF480 ERVV-1 ERVV-2 ZNF606 CD22 ZNF875 ZNF347

6.89e-051192407chr19q13
Cytoband16q13

NLRC5 MMP15

4.58e-043640216q13
Cytoband19q13.41

ZNF480 ERVV-1

2.13e-037840219q13.41
Cytoband17p13.1

DNAH2 KDM6B

4.79e-0311840217p13.1
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF737 ZXDC ZNF480 ZNF75A ZNF57 ZNF664 ZNF606 ZNF875 ZBTB21 ZNF347

2.67e-07718321028
Diseasecholesteryl ester measurement

NLRC5 EYS FADS3 ZNF664 MARCHF8

1.67e-05257375EFO_0010351
Diseaseretinitis pigmentosa (implicated_via_orthology)

SLC6A6 EYS

5.26e-0427372DOID:10584 (implicated_via_orthology)
Diseasebitter alcoholic beverage consumption measurement

DNAH2 FBXO40 KDM6B

6.22e-04133373EFO_0010092
DiseaseBreast adenocarcinoma

HERC2 PIK3CA

1.22e-0341372C0858252
DiseaseNeoplasm of uncertain or unknown behavior of breast

HERC2 PIK3CA

1.22e-0341372C0496956
Diseasefree cholesterol in medium HDL measurement

NLRC5 MARCHF8

2.42e-0358372EFO_0022267
Diseasetotal lipids in medium HDL measurement

NLRC5 MARCHF8

2.42e-0358372EFO_0022310
Diseasecholesterol in medium HDL measurement

NLRC5 MARCHF8

2.50e-0359372EFO_0021903
Diseaseprotein-glutamine gamma-glutamyltransferase e measurement

PTPN3 TNFAIP2

2.59e-0360372EFO_0020690
Diseasefree cholesterol in HDL measurement

NLRC5 MARCHF8

2.67e-0361372EFO_0022264
Diseasephospholipids in HDL measurement

NLRC5 MARCHF8

2.67e-0361372EFO_0022293
Diseasetotal lipids in HDL measurement

NLRC5 MARCHF8

2.85e-0363372EFO_0022307
DiseaseCorneal astigmatism

NECAB2 HERC2

4.22e-0377372EFO_1002040
Diseasefree cholesterol in large HDL measurement

NLRC5 MARCHF8

4.44e-0379372EFO_0022157
Diseasenon-melanoma skin carcinoma

DNAH2 ZNF480 HERC2

4.44e-03265373EFO_0009260
Diseaseserum gamma-glutamyl transferase measurement

PTPN3 EYS TNFAIP2 MMP15 MARCHF8

5.40e-03914375EFO_0004532
Diseaseeye color

EYS HERC2

5.72e-0390372EFO_0003949

Protein segments in the cluster

PeptideGeneStartEntry
ASGNHLSNCWICHNF

ERVV-2

36

B6SEH9
NLWKSCVEHHTFFQA

PTPN3

296

P26045
NNGTFCCNKWHHVVV

EYS

3056

Q5T1H1
DGWFSGTHKCHLNNS

GPR158

321

Q5T848
HSWGSNDQCQHFDTL

HERC2

731

O95714
GRKWNNHHLTFSIQN

MMP15

136

P51511
HSTHRTFGKQQWQQL

EIF3M

336

Q7L2H7
WNFHTGSCQHRAKVL

KDM6B

156

O15054
ASGNHLSNCWICHNF

ERVV-1

36

B6SEH8
FWQAHSGICTRTVQH

MLST8

26

Q9BVC4
DCSNFTNQHLGTHTW

FBXW12

51

Q6X9E4
CNSVNAGWNHDSTHV

KCTD1

176

Q719H9
IIFGTFTNQIHKWSH

PEDS1

176

A5PLL7
QSHSPWFNGTNKHTL

PHRF1

626

Q9P1Y6
GSLHFVHQACLQQWI

MARCHF8

101

Q5T0T0
LKGALQFNSHTLHQW

PIK3CA

866

P42336
LHVQGSDTWQSFIHC

NLRC5

61

Q86WI3
HTDIQSCLNGWFQHR

FBXO40

496

Q9UH90
KHDGWGKHSNCTHQQ

CD163

131

Q86VB7
QSWCLQHDLGHASIF

FADS3

176

Q9Y5Q0
TQGHWVFLANCHLSL

DNAH2

3886

Q9P225
WQHRPTQHNAACKQG

SCNN1D

171

P51172
FSPQWSHHGKIVTCQ

CD22

206

P20273
FTTTQWGSLTHHINN

MT-ND4

411

P03905
GNHFSDCHVAWVSAQ

RDH11

281

Q8TC12
QSFQKELPWAHCNHS

SLC6A6

151

P31641
ALAWASAQIHCQFHA

RGP1

41

Q92546
NEHGTNGIFCIAWSH

WDR17

476

Q8IZU2
GNACWVHKHFTEDIQ

SRPK3

411

Q9UPE1
TNFKVWTHCQTQHGI

ZBTB21

586

Q9ULJ3
WTHCQTQHGIVKNPS

ZBTB21

591

Q9ULJ3
QHFCTQHGSPATWLQ

TNFAIP2

561

Q03169
HFHASQNSWLCGSLV

ZXDC

756

Q2QGD7
CGKVFTQNSHLTNHW

ZNF347

406

Q96SE7
CGKVFIQNSHLAQHW

ZNF480

376

Q8WV37
ECGKAFNWSSHLQIH

ZNF664

91

Q8N3J9
CGKTFTWSSTLHNHV

ZNF57

481

Q68EA5
CGRHFSWKSNLKTHQ

ZNF875

446

P10072
WCGKSFSQNTNLHTH

ZNF75A

221

Q96N20
KSFNWNSHLIGHQRT

ZNF606

491

Q8WXB4
CGKAFNWSSHLTTHK

ZNF737

206

O75373
NHIKPSHSAAQTWCG

NECAB2

201

Q7Z6G3