Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	growth	PRICKLE1 CTC1 TRIM32 ISLR2 BMPR1B PRKCZ	3.18e-04	1235	17	6	GO:0040007
GeneOntologyBiologicalProcess	regionalization	PRICKLE1 TMEM67 DISP1 BMPR1B	5.33e-04	478	17	4	GO:0003002
GeneOntologyBiologicalProcess	neuron projection extension	PRICKLE1 ISLR2 PRKCZ	6.11e-04	207	17	3	GO:1990138
GeneOntologyBiologicalProcess	developmental growth	PRICKLE1 CTC1 ISLR2 BMPR1B PRKCZ	6.60e-04	911	17	5	GO:0048589
GeneOntologyBiologicalProcess	pattern specification process	PRICKLE1 TMEM67 DISP1 BMPR1B	7.64e-04	526	17	4	GO:0007389
GeneOntologyBiologicalProcess	neuron development	PRICKLE1 TRIM32 TMEM67 ISLR2 BMPR1B PRKCZ	7.89e-04	1463	17	6	GO:0048666
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process	PRICKLE1 TRIM32 TMEM67	8.08e-04	228	17	3	GO:0045732
Domain	Znf_C3HC4_RING-type	RNF149 TRIM32	9.30e-03	172	16	2	IPR018957
Domain	zf-C3HC4	RNF149 TRIM32	1.53e-02	223	16	2	PF00097
Pubmed	Inverse Correlation of TRIM32 and Protein Kinase C ζ in T Helper Type 2-Biased Inflammation.	TRIM32 PRKCZ	2.25e-07	2	17	2	33096083
Pubmed	Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.	PRICKLE1 PRKCZ	2.35e-05	15	17	2	26883626
Pubmed	The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.	TMEM67 PRKCZ	2.35e-05	15	17	2	26035863
Pubmed	USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components.	PRICKLE1 PRKCZ	5.16e-05	22	17	2	35440748
Pubmed	Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.	PRICKLE1 PRKCZ	6.17e-05	24	17	2	22333836
Pubmed	Bardet-Biedl Syndrome Overview	TRIM32 TMEM67	7.84e-05	27	17	2	20301537
Pubmed	Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	TRIM32 TMEM67	2.94e-04	52	17	2	20301743
Cytoband	8q22.1	TMEM67 RAD54B	9.98e-05	40	17	2	8q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8q22	TMEM67 RAD54B	1.75e-03	168	17	2	chr8q22
GeneFamily	Ring finger proteins	RNF149 TRIM32	1.38e-02	275	12	2	58
Disease	Bardet-Biedl syndrome (is_implicated_in)	TRIM32 TMEM67	2.50e-05	14	16	2	DOID:1935 (is_implicated_in)
Disease	Bardet-Biedl syndrome	TRIM32 TMEM67	4.20e-05	18	16	2	cv:C0752166
Disease	Ciliopathies	TRIM32 TMEM67	1.60e-03	110	16	2	C4277690
Disease	Polydactyly	TRIM32 TMEM67	1.80e-03	117	16	2	C0152427

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELACKLCPHVLRHHQ	CTC1	476	Q2NKJ3
RPKVLRCKCHHHCPE	BMPR1B	26	O00238
HIHHCPCLQGRVKPA	DISP1	1331	Q96F81
VPLLGAACCHLLAKH	ISLR2	606	Q6UXK2
HLICIGALKKLCNHP	RAD54B	581	Q9Y620
IRIHTGEKPHRCHLC	IKZF5	101	Q9H5V7
KIHCGRHHAELLKPR	PRICKLE1	176	Q96MT3
PVLKRPRHVHCHLCC	METTL17	391	Q9H7H0
LVHTARCCLAHLLHK	LIPE	376	Q05469
KCHCPIGHILVERDI	TMEM67	126	Q5HYA8
QLRPKLLHCGHTICR	TRIM32	31	Q13049
IIRILPCKHIFHRIC	RNF149	281	Q8NC42
CLIRKPLRSLHCHVC	ZDHHC13	431	Q8IUH4
CLRGLHLHIVPCKHV	WFIKKN1	146	Q96NZ8
HLCLAHHPPLVCATL	TMEM219	11	Q86XT9
LRELGEKAHHCPLCH	ZNF142	211	P52746
LLVHKRCHGLVPLTC	PRKCZ	166	Q05513