Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	1.73e-05	6	22	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	3.23e-05	8	22	2	GO:0032453
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5C KDM5D	4.30e-04	28	22	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5C KDM5D	5.28e-04	31	22	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5C KDM5D	5.63e-04	32	22	2	GO:0140457
GeneOntologyMolecularFunction	demethylase activity	KDM5C KDM5D	1.07e-03	44	22	2	GO:0032451
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM5C KDM5D	2.31e-03	65	22	2	GO:0016706
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX17 SHOX2 MAZ ATF5 NOBOX FOXE3	3.45e-03	1412	22	6	GO:0000981
GeneOntologyMolecularFunction	dioxygenase activity	KDM5C KDM5D	5.17e-03	98	22	2	GO:0051213
GeneOntologyBiologicalProcess	endodermal digestive tract morphogenesis	SOX17 FGFR2	6.51e-06	4	22	2	GO:0061031
GeneOntologyBiologicalProcess	heart morphogenesis	SOX17 SHOX2 FGFR2 SLIT3 SYNPO2L	1.87e-05	321	22	5	GO:0003007
GeneOntologyBiologicalProcess	digestive tract morphogenesis	SOX17 SHOX2 FGFR2	3.29e-05	59	22	3	GO:0048546
GeneOntologyBiologicalProcess	olfactory bulb interneuron development	ATF5 SLIT3	5.94e-05	11	22	2	GO:0021891
GeneOntologyBiologicalProcess	neuron development	SHOX2 ACHE ARHGAP32 PRKCI FGFR2 SAMD4B ATF5 SLIT3	8.17e-05	1463	22	8	GO:0048666
GeneOntologyBiologicalProcess	branching morphogenesis of a nerve	SHOX2 FGFR2	1.13e-04	15	22	2	GO:0048755
GeneOntologyBiologicalProcess	negative regulation of apoptotic process	BCL2L12 PRKCI MAZ FGFR2 ATF5 FKBP8 FOXE3	1.22e-04	1133	22	7	GO:0043066
GeneOntologyBiologicalProcess	eye development	ACHE PRKCI FGFR2 FKBP8 FOXE3	1.27e-04	480	22	5	GO:0001654
GeneOntologyBiologicalProcess	visual system development	ACHE PRKCI FGFR2 FKBP8 FOXE3	1.31e-04	483	22	5	GO:0150063
GeneOntologyBiologicalProcess	sensory system development	ACHE PRKCI FGFR2 FKBP8 FOXE3	1.41e-04	491	22	5	GO:0048880
GeneOntologyBiologicalProcess	negative regulation of programmed cell death	BCL2L12 PRKCI MAZ FGFR2 ATF5 FKBP8 FOXE3	1.50e-04	1171	22	7	GO:0043069
GeneOntologyBiologicalProcess	regulation of neurogenesis	SHOX2 ACHE ARHGAP32 PRKCI ATF5	1.76e-04	515	22	5	GO:0050767
GeneOntologyBiologicalProcess	embryonic digestive tract morphogenesis	SHOX2 FGFR2	2.25e-04	21	22	2	GO:0048557
GeneOntologyBiologicalProcess	positive regulation of axonogenesis	SHOX2 ACHE ARHGAP32	2.35e-04	114	22	3	GO:0050772
GeneOntologyBiologicalProcess	animal organ morphogenesis	SOX17 SHOX2 PRKCI FGFR2 SLIT3 SYNPO2L FOXE3	2.47e-04	1269	22	7	GO:0009887
GeneOntologyBiologicalProcess	regulation of stem cell proliferation	SOX17 SHOX2 FGFR2	2.66e-04	119	22	3	GO:0072091
GeneOntologyBiologicalProcess	axonogenesis	SHOX2 ACHE ARHGAP32 FGFR2 SLIT3	2.73e-04	566	22	5	GO:0007409
GeneOntologyBiologicalProcess	olfactory bulb interneuron differentiation	ATF5 SLIT3	3.48e-04	26	22	2	GO:0021889
GeneOntologyBiologicalProcess	regulation of nervous system development	SHOX2 ACHE ARHGAP32 PRKCI ATF5	4.31e-04	625	22	5	GO:0051960
GeneOntologyBiologicalProcess	axon development	SHOX2 ACHE ARHGAP32 FGFR2 SLIT3	4.88e-04	642	22	5	GO:0061564
GeneOntologyBiologicalProcess	positive regulation of neurogenesis	SHOX2 ACHE ARHGAP32 PRKCI	4.89e-04	354	22	4	GO:0050769
GeneOntologyBiologicalProcess	digestive tract development	SOX17 SHOX2 FGFR2	5.45e-04	152	22	3	GO:0048565
GeneOntologyBiologicalProcess	stem cell proliferation	SOX17 SHOX2 FGFR2	5.88e-04	156	22	3	GO:0072089
GeneOntologyBiologicalProcess	embryonic digestive tract development	SHOX2 FGFR2	6.33e-04	35	22	2	GO:0048566
GeneOntologyBiologicalProcess	cardiac chamber morphogenesis	SHOX2 FGFR2 SLIT3	6.45e-04	161	22	3	GO:0003206
GeneOntologyBiologicalProcess	positive regulation of mesenchymal cell proliferation	SHOX2 FGFR2	6.69e-04	36	22	2	GO:0002053
GeneOntologyBiologicalProcess	digestive system development	SOX17 SHOX2 FGFR2	7.17e-04	167	22	3	GO:0055123
GeneOntologyBiologicalProcess	smoothened signaling pathway	SHOX2 FGFR2 FKBP8	8.35e-04	176	22	3	GO:0007224
GeneOntologyBiologicalProcess	sensory organ development	ACHE PRKCI FGFR2 FKBP8 FOXE3	8.74e-04	730	22	5	GO:0007423
GeneOntologyBiologicalProcess	positive regulation of nervous system development	SHOX2 ACHE ARHGAP32 PRKCI	9.10e-04	418	22	4	GO:0051962
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	SHOX2 ACHE ARHGAP32 FGFR2 SLIT3	9.75e-04	748	22	5	GO:0048667
GeneOntologyBiologicalProcess	camera-type eye development	ACHE FGFR2 FKBP8 FOXE3	9.77e-04	426	22	4	GO:0043010
GeneOntologyBiologicalProcess	lens fiber cell differentiation	FGFR2 FOXE3	1.00e-03	44	22	2	GO:0070306
GeneOntologyBiologicalProcess	heart development	SOX17 SHOX2 FGFR2 SLIT3 SYNPO2L	1.03e-03	757	22	5	GO:0007507
GeneOntologyBiologicalProcess	neural tube patterning	SOX17 FKBP8	1.05e-03	45	22	2	GO:0021532
GeneOntologyBiologicalProcess	regulation of mesenchymal cell proliferation	SHOX2 FGFR2	1.05e-03	45	22	2	GO:0010464
GeneOntologyBiologicalProcess	regulation of axonogenesis	SHOX2 ACHE ARHGAP32	1.07e-03	192	22	3	GO:0050770
GeneOntologyBiologicalProcess	cell morphogenesis	SOX17 SHOX2 ACHE ARHGAP32 FGFR2 SLIT3	1.24e-03	1194	22	6	GO:0000902
GeneOntologyBiologicalProcess	neuron projection morphogenesis	SHOX2 ACHE ARHGAP32 FGFR2 SLIT3	1.33e-03	802	22	5	GO:0048812
GeneOntologyBiologicalProcess	cardiac chamber development	SHOX2 FGFR2 SLIT3	1.43e-03	212	22	3	GO:0003205
GeneOntologyBiologicalProcess	olfactory bulb development	ATF5 SLIT3	1.45e-03	53	22	2	GO:0021772
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	SHOX2 ACHE ARHGAP32 FGFR2 SLIT3	1.46e-03	819	22	5	GO:0120039
GeneOntologyBiologicalProcess	growth	SOX17 ARHGAP32 FGFR2 ATF5 SLIT3 FKBP8	1.48e-03	1235	22	6	GO:0040007
GeneOntologyBiologicalProcess	cell projection morphogenesis	SHOX2 ACHE ARHGAP32 FGFR2 SLIT3	1.52e-03	826	22	5	GO:0048858
GeneOntologyBiologicalProcess	olfactory lobe development	ATF5 SLIT3	1.62e-03	56	22	2	GO:0021988
GeneOntologyBiologicalProcess	ventricular septum morphogenesis	FGFR2 SLIT3	1.62e-03	56	22	2	GO:0060412
GeneOntologyBiologicalProcess	positive regulation of cell projection organization	SHOX2 ACHE ARHGAP32 PRKCI	1.69e-03	494	22	4	GO:0031346
GeneOntologyBiologicalProcess	mesenchymal cell proliferation	SHOX2 FGFR2	1.79e-03	59	22	2	GO:0010463
GeneOntologyBiologicalProcess	neuron projection development	SHOX2 ACHE ARHGAP32 PRKCI FGFR2 SLIT3	1.81e-03	1285	22	6	GO:0031175
GeneOntologyBiologicalProcess	regulation of morphogenesis of a branching structure	SHOX2 FGFR2	2.17e-03	65	22	2	GO:0060688
GeneOntologyBiologicalProcess	developmental growth	ARHGAP32 FGFR2 ATF5 SLIT3 FKBP8	2.34e-03	911	22	5	GO:0048589
GeneOntologyBiologicalProcess	positive regulation of stem cell proliferation	SHOX2 FGFR2	2.65e-03	72	22	2	GO:2000648
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SOX17 BCL2L12 MAZ FGFR2 ATF5 NOBOX	2.71e-03	1390	22	6	GO:0045944
GeneOntologyBiologicalProcess	heart valve development	SHOX2 SLIT3	3.11e-03	78	22	2	GO:0003170
GeneOntologyBiologicalProcess	animal organ formation	SOX17 FGFR2	3.11e-03	78	22	2	GO:0048645
GeneOntologyBiologicalProcess	receptor metabolic process	ACHE MVB12A	3.43e-03	82	22	2	GO:0043112
GeneOntologyBiologicalProcess	regulation of neuron projection development	SHOX2 ACHE ARHGAP32 PRKCI	3.67e-03	612	22	4	GO:0010975
GeneOntologyBiologicalProcess	positive regulation of cell development	SHOX2 ACHE ARHGAP32 PRKCI	3.71e-03	614	22	4	GO:0010720
GeneOntologyBiologicalProcess	developmental growth involved in morphogenesis	ARHGAP32 FGFR2 SLIT3	3.79e-03	299	22	3	GO:0060560
GeneOntologyBiologicalProcess	ovarian follicle development	FANCG NOBOX	3.85e-03	87	22	2	GO:0001541
GeneOntologyCellularComponent	chromatin	SOX17 SHOX2 FANCG KDM5C ATF5 KDM5D NOBOX FOXE3	8.06e-05	1480	22	8	GO:0000785
HumanPheno	Corneal perforation	FGFR2 FOXE3	4.85e-06	3	7	2	HP:0100583
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	7.94e-06	4	22	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	7.94e-06	4	22	2	PF08429
Domain	zf-C5HC2	KDM5C KDM5D	1.32e-05	5	22	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	1.32e-05	5	22	2	IPR004198
Domain	JmjN	KDM5C KDM5D	5.93e-05	10	22	2	PF02375
Domain	JmjN	KDM5C KDM5D	5.93e-05	10	22	2	SM00545
Domain	JMJN	KDM5C KDM5D	5.93e-05	10	22	2	PS51183
Domain	JmjN	KDM5C KDM5D	5.93e-05	10	22	2	IPR003349
Domain	-	KDM5C KDM5D	1.38e-04	15	22	2	1.10.150.60
Domain	ARID	KDM5C KDM5D	1.38e-04	15	22	2	PF01388
Domain	BRIGHT	KDM5C KDM5D	1.38e-04	15	22	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	1.38e-04	15	22	2	IPR001606
Domain	ARID	KDM5C KDM5D	1.38e-04	15	22	2	PS51011
Domain	JmjC	KDM5C KDM5D	3.60e-04	24	22	2	PF02373
Domain	JMJC	KDM5C KDM5D	6.43e-04	32	22	2	PS51184
Domain	JmjC_dom	KDM5C KDM5D	6.43e-04	32	22	2	IPR003347
Domain	JmjC	KDM5C KDM5D	6.84e-04	33	22	2	SM00558
Domain	Zinc_finger_PHD-type_CS	KDM5C KDM5D	2.63e-03	65	22	2	IPR019786
Domain	PHD	KDM5C KDM5D	3.49e-03	75	22	2	PF00628
Domain	Znf_PHD-finger	KDM5C KDM5D	3.86e-03	79	22	2	IPR019787
Domain	PHD	KDM5C KDM5D	4.87e-03	89	22	2	SM00249
Domain	Znf_PHD	KDM5C KDM5D	5.09e-03	91	22	2	IPR001965
Domain	ZF_PHD_2	KDM5C KDM5D	5.53e-03	95	22	2	PS50016
Domain	ZF_PHD_1	KDM5C KDM5D	5.65e-03	96	22	2	PS01359
Domain	-	ACHE ACOT2	8.56e-03	119	22	2	3.40.50.1820
Domain	AB_hydrolase	ACHE ACOT2	8.56e-03	119	22	2	IPR029058
Domain	TPR	FANCG FKBP8	9.99e-03	129	22	2	SM00028
Domain	TPR_repeat	FANCG FKBP8	1.06e-02	133	22	2	IPR019734
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	3.82e-07	2	22	2	32081420
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	3.82e-07	2	22	2	9060413
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	3.82e-07	2	22	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	3.82e-07	2	22	2	16416087
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	3.82e-07	2	22	2	7524912
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	1.15e-06	3	22	2	7544442
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	2.29e-06	4	22	2	16541399
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	2.29e-06	4	22	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	2.29e-06	4	22	2	7951230
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	2.29e-06	4	22	2	17320160
Pubmed	Regional regulation of palatal growth and patterning along the anterior-posterior axis in mice.	SHOX2 FGFR2	2.29e-06	4	22	2	16313398
Pubmed	Cloning and characterization of four murine homeobox genes.	SHOX2 NOBOX	3.82e-06	5	22	2	8855241
Pubmed	Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate.	SHOX2 FGFR2	8.01e-06	7	22	2	16141225
Pubmed	Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.	SHOX2 KDM5C	1.07e-05	8	22	2	24122442
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX17 SHOX2 MAZ ATF5 NOBOX FOXE3	1.62e-05	908	22	6	19274049
Pubmed	Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis.	SOX17 FGFR2	2.09e-05	11	22	2	24812002
Pubmed	PDGF Signaling in Primitive Endoderm Cell Survival Is Mediated by PI3K-mTOR Through p53-Independent Mechanism.	SOX17 FGFR2	2.09e-05	11	22	2	30913328
Pubmed	Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation.	FGFR2 NOBOX	2.97e-05	13	22	2	35104175
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5C KDM5D	2.97e-05	13	22	2	24619213
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	2.97e-05	13	22	2	14660691
Pubmed	A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.	SOX17 FGFR2	2.97e-05	13	22	2	29964027
Pubmed	Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency.	SOX17 FGFR2	3.46e-05	14	22	2	28552557
Pubmed	The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.	SHOX2 FGFR2	3.46e-05	14	22	2	18948418
Pubmed	The septum transversum mesenchyme induces gall bladder development.	SOX17 FGFR2	3.99e-05	15	22	2	23951403
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	KDM5C KDM5D	3.99e-05	15	22	2	14762062
Pubmed	FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate.	SHOX2 FGFR2	5.16e-05	17	22	2	29342370
Pubmed	Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.	FGFR2 FOXE3	5.16e-05	17	22	2	18455718
Pubmed	FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.	ACHE FGFR2	5.81e-05	18	22	2	12682014
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM5C KDM5D	5.81e-05	18	22	2	12023983
Pubmed	Midline radial glia translocation and corpus callosum formation require FGF signaling.	FGFR2 SLIT3	5.81e-05	18	22	2	16715082
Pubmed	Wntless is required for peripheral lung differentiation and pulmonary vascular development.	SOX17 FGFR2	7.21e-05	20	22	2	23523683
Pubmed	The function of FGF signaling in the lens placode.	FGFR2 FOXE3	9.59e-05	23	22	2	21223962
Pubmed	Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.	PRKCI FGFR2	1.33e-04	27	22	2	23466739
Pubmed	Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate.	SHOX2 FGFR2	1.43e-04	28	22	2	19782673
Pubmed	Crk proteins transduce FGF signaling to promote lens fiber cell elongation.	FGFR2 FOXE3	1.76e-04	31	22	2	29360039
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	SHOX2 KDM5C ATF5 KDM5D FOXE3	1.86e-04	877	22	5	20211142
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5C KDM5D	1.99e-04	33	22	2	26864203
Pubmed	Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.	SOX17 SLIT3	2.12e-04	34	22	2	30504829
Pubmed	FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors.	PRKCI FGFR2	2.24e-04	35	22	2	21074523
Pubmed	WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.	SOX17 PRKCI	3.24e-04	42	22	2	31776260
Pubmed	NANOG initiates epiblast fate through the coordination of pluripotency genes expression.	SOX17 FGFR2	3.89e-04	46	22	2	35729116
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	RGL3 ACOT2 MVB12A	4.16e-04	233	22	3	37704626
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM5C KDM5D	4.41e-04	49	22	2	34368113
Pubmed	Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism.	FANCG ACOT2	5.36e-04	54	22	2	25464930
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM5C KDM5D	5.97e-04	57	22	2	18022353
Cytoband	19q13.3	BCL2L12 ATF5	7.11e-04	82	22	2	19q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	RGL3 FKBP8 MVB12A	6.28e-03	797	22	3	chr19p13
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	1.09e-04	15	19	2	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	2.85e-04	24	19	2	485
GeneFamily	PHD finger proteins	KDM5C KDM5D	3.97e-03	90	19	2	88
GeneFamily	PRD class homeoboxes and pseudogenes	SHOX2 NOBOX	4.14e-03	92	19	2	521
Coexpression	GSE16266_CTRL_VS_LPS_STIM_MEF_DN	FANCG MAZ SLIT3 FKBP8	2.16e-05	200	22	4	M7212
Computational	Pol II transcription.	FANCG KDM5C MAZ	1.76e-04	71	17	3	MODULE_308
Drug	Piperine [94-62-2]; Down 200; 14uM; PC3; HT_HG-U133A	KDM5C FGFR2 ATF5 FKBP8	3.12e-05	191	22	4	4247_DN
Drug	Flunisolide [3385-03-3]; Up 200; 9.2uM; PC3; HT_HG-U133A	ACHE KDM5C MAZ FKBP8	3.18e-05	192	22	4	4303_UP
Drug	Dentacolor	ARHGAP32 KDM5D	3.20e-05	9	22	2	CID003035662
Drug	Simvastatin [79902-63-9]; Down 200; 9.6uM; PC3; HT_HG-U133A	KDM5C MAZ FGFR2 FKBP8	3.31e-05	194	22	4	4244_DN
Drug	Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Down 200; 7.6uM; PC3; HT_HG-U133A	MAZ FGFR2 ATF5 FKBP8	3.31e-05	194	22	4	4248_DN
Drug	Doxylamine succinate [562-10-7]; Down 200; 10.2uM; PC3; HT_HG-U133A	MAZ FGFR2 ATF5 FKBP8	3.38e-05	195	22	4	4235_DN
Drug	Sulfabenzamide [127-71-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A	SHOX2 KDM5C MAZ FKBP8	3.59e-05	198	22	4	4979_DN
Drug	Theophylline monohydrate [5967-84-0]; Down 200; 20.2uM; PC3; HT_HG-U133A	KDM5C FGFR2 ATF5 FKBP8	3.66e-05	199	22	4	4228_DN
Drug	silicon carbide	ARHGAP32 KDM5D	5.85e-05	12	22	2	CID000009863
Drug	soman	ACHE BCL2L12 PRKCI	9.30e-05	92	22	3	CID000007305
Drug	MGA-100	BCL2L12 KDM5D	1.35e-04	18	22	2	CID000018020
Drug	dichloromethanediamine	FANCG BCL2L12 PRKCI ATF5 FKBP8	1.38e-04	539	22	5	CID005311048
Drug	Super-Bond	ARHGAP32 KDM5D	1.51e-04	19	22	2	CID000123788
Drug	biperiden	ACHE BCL2L12	2.23e-04	23	22	2	CID000002381
Drug	AZFd	KDM5C KDM5D	2.23e-04	23	22	2	CID000196489
Drug	Q-MS	SHOX2 KDM5D	2.86e-04	26	22	2	CID000151506
Drug	zinc phosphate	ARHGAP32 KDM5D	3.08e-04	27	22	2	CID000024519
Drug	pseudohypericin	PRKCI KDM5D	3.08e-04	27	22	2	CID005281751
Drug	AC1O3R20	ACHE KDM5C	3.32e-04	28	22	2	CID006335051
Drug	muscarine	ACHE PRKCI MAZ	3.49e-04	144	22	3	CID000009308
Drug	AC1NRAS8	ARHGAP32 SLIT3	4.34e-04	32	22	2	CID005288068
Drug	trihexyphenidyl	ACHE BCL2L12	4.34e-04	32	22	2	CID000005572
Drug	anti-K	ACHE FGFR2	4.62e-04	33	22	2	CID000005337
Drug	Te Al	ARHGAP32 KDM5D	5.20e-04	35	22	2	CID000168005
Drug	iBVE	ARHGAP32 MAZ	5.50e-04	36	22	2	CID000007992
Drug	digoxigenine	ACHE PRKCI	6.80e-04	40	22	2	CID000015478
Drug	thioflavin	ACHE BCL2L12	6.80e-04	40	22	2	CID000022251
Drug	acrylic acid	ARHGAP32 KDM5D	7.14e-04	41	22	2	CID000006581
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A_EA	KDM5C FGFR2 FKBP8	7.48e-04	187	22	3	1070_UP
Drug	Mepenzolate bromide [76-90-4]; Up 200; 9.6uM; PC3; HT_HG-U133A	KDM5C MAZ FKBP8	7.72e-04	189	22	3	4304_UP
Drug	17-AAG; Down 200; 1uM; HL60; HT_HG-U133A	ARHGAP32 FGFR2 ATF5	7.96e-04	191	22	3	2678_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A	ARHGAP32 ATF5 SYNPO2L	8.08e-04	192	22	3	2703_DN
Drug	Deltaline [6836-11-9]; Up 200; 7.8uM; PC3; HT_HG-U133A	MAZ FGFR2 FKBP8	8.20e-04	193	22	3	4306_UP
Drug	Trimethylcolchicinic acid [3482-37-9]; Down 200; 11.6uM; PC3; HT_HG-U133A	KDM5C MAZ FGFR2	8.20e-04	193	22	3	4202_DN
Drug	Cefalonium [5575-21-3]; Down 200; 8.8uM; PC3; HT_HG-U133A	MAZ FGFR2 FKBP8	8.20e-04	193	22	3	4245_DN
Drug	Letrozole [112809-51-5]; Down 200; 14uM; PC3; HT_HG-U133A	KDM5C MAZ FGFR2	8.20e-04	193	22	3	4240_DN
Drug	Amprolium hydrochloride [137-88-2]; Down 200; 12.6uM; PC3; HT_HG-U133A	MAZ FGFR2 FKBP8	8.20e-04	193	22	3	4241_DN
Drug	Isoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; PC3; HT_HG-U133A	MAZ FGFR2 FKBP8	8.20e-04	193	22	3	4205_DN
Drug	Midodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; PC3; HT_HG-U133A	ARHGAP32 KDM5C FKBP8	8.32e-04	194	22	3	2087_DN
Drug	Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SHOX2 KDM5C FGFR2	8.32e-04	194	22	3	3977_DN
Drug	Indoprofen [31842-01-0]; Down 200; 14.2uM; PC3; HT_HG-U133A	MAZ FGFR2 ATF5	8.32e-04	194	22	3	4249_DN
Drug	Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; PC3; HT_HG-U133A	SHOX2 KDM5C FKBP8	8.32e-04	194	22	3	4492_DN
Drug	0317956-0000 [391210-11-0]; Down 200; 10uM; PC3; HT_HG-U133A	KDM5C MAZ FKBP8	8.32e-04	194	22	3	4331_DN
Drug	Isradipine [75695-93-1]; Down 200; 10.8uM; PC3; HT_HG-U133A	ARHGAP32 KDM5C MAZ	8.32e-04	194	22	3	6347_DN
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; PC3; HT_HG-U133A	MAZ FGFR2 ATF5	8.32e-04	194	22	3	4242_DN
Drug	Phensuximide [86-34-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A	KDM5C ATF5 FKBP8	8.32e-04	194	22	3	3521_DN
Drug	Isotretinoin	SOX17 ACOT2 ATF5 SLIT3 FKBP8	8.42e-04	799	22	5	ctd:D015474
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; PC3; HT_HG-U133A	ACHE KDM5C MAZ	8.45e-04	195	22	3	4312_UP
Drug	Atovaquone [95233-18-4]; Down 200; 11uM; PC3; HT_HG-U133A	MAZ FGFR2 FKBP8	8.45e-04	195	22	3	4201_DN
Drug	Isoniazid [54-85-3]; Down 200; 29.2uM; PC3; HT_HG-U133A	ARHGAP32 KDM5C FGFR2	8.45e-04	195	22	3	5840_DN
Drug	Chlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A	ARHGAP32 MAZ ATF5	8.45e-04	195	22	3	1700_DN
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A	ARHGAP32 FGFR2 SYNPO2L	8.45e-04	195	22	3	2701_DN
Drug	Gentamicine sulfate [1405-41-0]; Down 200; 2.6uM; MCF7; HT_HG-U133A	SHOX2 KDM5C FKBP8	8.45e-04	195	22	3	2245_DN
Drug	Sulfachloropyridazine [80-32-0]; Down 200; 14uM; PC3; HT_HG-U133A	KDM5C MAZ FKBP8	8.45e-04	195	22	3	4326_DN
Drug	Propofol [2078-54-8]; Down 200; 22.4uM; PC3; HT_HG-U133A	SHOX2 FGFR2 FKBP8	8.45e-04	195	22	3	6707_DN
Drug	Carbachol [51-83-2]; Up 200; 21.8uM; HL60; HT_HG-U133A	SHOX2 ACHE FGFR2	8.58e-04	196	22	3	3042_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	ARHGAP32 FGFR2 FKBP8	8.58e-04	196	22	3	1628_DN
Drug	Seneciphylline [480-81-9]; Down 200; 12uM; PC3; HT_HG-U133A	KDM5C MAZ FGFR2	8.58e-04	196	22	3	4238_DN
Drug	D-cycloserine [68-41-7]; Down 200; 39.2uM; MCF7; HT_HG-U133A	KDM5C FGFR2 FKBP8	8.58e-04	196	22	3	6782_DN
Drug	Rapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A	ARHGAP32 FGFR2 ATF5	8.58e-04	196	22	3	2667_DN
Drug	N-WB	SOX17 ACHE	8.60e-04	45	22	2	CID000091419
Drug	procyanidin B2	PRKCI KDM5D	8.60e-04	45	22	2	CID000122738
Drug	Furaltadone hydrochloride [3759-92-0]; Up 200; 11uM; MCF7; HT_HG-U133A	KDM5C FGFR2 FKBP8	8.70e-04	197	22	3	3413_UP
Drug	Dimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; PC3; HT_HG-U133A	MAZ FGFR2 ATF5	8.70e-04	197	22	3	4207_DN
Drug	2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A	KDM5C FGFR2 FKBP8	8.70e-04	197	22	3	5211_DN
Drug	17-DMAG; Down 200; 0.1uM; HL60; HT_HG-U133A	MAZ FGFR2 SYNPO2L	8.70e-04	197	22	3	2673_DN
Drug	Trichlormethiazide [133-67-5]; Down 200; 10.6uM; HL60; HT_HG-U133A	SHOX2 FGFR2 FKBP8	8.70e-04	197	22	3	2998_DN
Drug	Cyanocobalamin [68-19-9]; Up 200; 3uM; HL60; HT_HG-U133A	SHOX2 MAZ FKBP8	8.70e-04	197	22	3	1315_UP
Drug	Pentolinium bitartrate [52-62-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A	SHOX2 KDM5C ATF5	8.70e-04	197	22	3	4699_DN
Drug	Chlorhexidine [55-56-1]; Up 200; 8uM; PC3; HG-U133A	MAZ FGFR2 SLIT3	8.83e-04	198	22	3	1942_UP
Drug	SC 19220; Down 200; 10uM; PC3; HT_HG-U133A	ARHGAP32 KDM5C FKBP8	8.83e-04	198	22	3	7095_DN
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A_EA	ARHGAP32 KDM5C FGFR2	8.83e-04	198	22	3	1073_DN
Drug	Mianserine hydrochloride [21535-47-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	ARHGAP32 KDM5C FKBP8	8.83e-04	198	22	3	2068_DN
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	SHOX2 MAZ FKBP8	8.83e-04	198	22	3	6446_DN
Drug	Midecamycin [35457-80-8]; Down 200; 5uM; MCF7; HT_HG-U133A	KDM5C MAZ FKBP8	8.83e-04	198	22	3	5345_DN
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A_EA	KDM5C ATF5 FKBP8	8.83e-04	198	22	3	1020_DN
Drug	Roxarsone [121-19-7]; Down 200; 15.2uM; MCF7; HT_HG-U133A	ARHGAP32 KDM5C MAZ	8.83e-04	198	22	3	5470_DN
Drug	Canavanine sulfate monohydrate (L,+) [206996-57-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	SHOX2 KDM5C FKBP8	8.83e-04	198	22	3	4782_UP
Drug	rosiglitazone; Down 200; 10uM; HL60; HT_HG-U133A	ARHGAP32 FGFR2 SYNPO2L	8.96e-04	199	22	3	2693_DN
Drug	Isoxicam [34552-84-6]; Up 200; 12uM; HL60; HT_HG-U133A	FGFR2 ATF5 FKBP8	8.96e-04	199	22	3	1862_UP
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A	SHOX2 FGFR2 FKBP8	8.96e-04	199	22	3	2215_DN
Drug	(+/-)-blebbistatin; Down 200; 17uM; MCF7; HT_HG-U133A_EA	KDM5C FGFR2 ATF5	8.96e-04	199	22	3	954_DN
Drug	Acenocoumarol [152-72-7]; Down 200; 11.4uM; PC3; HT_HG-U133A	KDM5C MAZ ATF5	8.96e-04	199	22	3	2077_DN
Drug	Chloropyramine hydrochloride [6170-42-9]; Down 200; 12.2uM; HL60; HT_HG-U133A	SHOX2 KDM5C FGFR2	8.96e-04	199	22	3	3011_DN
Drug	Brompheniramine maleate [980-71-2]; Down 200; 9.2uM; PC3; HT_HG-U133A	MAZ FGFR2 FKBP8	8.96e-04	199	22	3	4013_DN
Drug	Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A	SHOX2 KDM5C FKBP8	8.96e-04	199	22	3	4765_DN
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A	SHOX2 ATF5 FKBP8	9.09e-04	200	22	3	3322_UP
Drug	nordihydroguaiaretic acid; Up 200; 1uM; HL60; HT_HG-U133A	SHOX2 FGFR2 FKBP8	9.09e-04	200	22	3	1164_UP
Drug	Carteolol hydrochloride [51781-21-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	SHOX2 KDM5C FGFR2	9.09e-04	200	22	3	3276_DN
Drug	Sulfathiazole [72-14-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A	SHOX2 KDM5C FGFR2	9.09e-04	200	22	3	4769_UP
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	3.18e-06	4	22	2	DOID:0060809 (implicated_via_orthology)
Disease	primary pulmonary hypertension (is_marker_for)	SOX17 FGFR2	1.48e-05	8	22	2	DOID:14557 (is_marker_for)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	6.33e-05	16	22	2	DOID:0050888 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ARHGAP32 KDM5C KDM5D	1.92e-04	152	22	3	DOID:0060041 (implicated_via_orthology)
Disease	Malignant Head and Neck Neoplasm	FANCG FGFR2	4.93e-04	44	22	2	C0278996
Disease	high grade glioma (implicated_via_orthology)	PRKCI FGFR2	4.93e-04	44	22	2	DOID:3070 (implicated_via_orthology)
Disease	electrocardiography	SHOX2 ACHE FGFR2 SYNPO2L	5.82e-04	530	22	4	EFO_0004327
Disease	Huntington's disease (is_marker_for)	ACHE KDM5C	7.15e-04	53	22	2	DOID:12858 (is_marker_for)
Disease	intellectual disability (implicated_via_orthology)	KDM5C KDM5D	1.42e-03	75	22	2	DOID:1059 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAFLGIPFAEPPMGP	ACHE	61	P22303
MGRPAGLFPPLCPFL	BCL2L12	1	Q9HB09
FLPPEPGPFPGIVDM	ACOT2	211	P49753
QMEDFFLDAPPLPPP	ATF5	111	Q9Y2D1
LPPPEDSLFMFPCGP	NOBOX	551	O60393
SVFSPDPMPYEPCLP	FGFR2	796	P21802
FPCVPERPGMPCPGE	PRKCI	106	P41743
MEPGCDEFLPPPECP	KDM5D	1	Q9BY66
MFPVFPCTLLAPPFP	MAZ	1	P56270
PSPPGPCMPEVFLEA	FANCG	386	O15287
PCGFPAPLPPTRMME	ARHGAP32	1406	A7KAX9
TACLLGFLLPPMPPP	RGL3	106	Q3MIN7
PLPLGFSPVCDPMDS	MVB12A	81	Q96EY5
FLAAMEPEPAPAPAP	FKBP8	76	Q14318
TAGHPEPCLMFRPPP	SLC22A13	76	Q9Y226
MFCFDEVPPTPGPIA	SYNPO2L	861	Q9H987
DPDPAFFAAPMPGDC	SOX17	231	Q9H6I2
DMDPPAAFSGFPALP	FOXE3	6	Q13461
MFPAPPFGLPLATLA	SHOX2	276	O60902
PQGFSGPFCEHPPPM	SLIT3	1101	O75094
AILMFPPDCPVPGPD	SAMD4B	651	Q5PRF9
MEPGSDDFLPPPECP	KDM5C	1	P41229