Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE1 PTK2B SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.96e-1228617GO:0099602
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.78e-1027616GO:0030548
GeneOntologyMolecularFunctiondynein intermediate chain binding

SPTBN5 DNAH17 DNAH1 DNAH11

4.83e-0637614GO:0045505
GeneOntologyMolecularFunctionprotein kinase binding

SPDYE1 PTK2B PKD1 SPDYE2 SPDYE21 PRMT1 SPDYE5 SPDYE18 TEX14 SPDYE2B SPDYE6 SPDYE16

1.09e-058736112GO:0019901
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH17 DNAH1 DNAH11

2.14e-0518613GO:0008569
GeneOntologyMolecularFunctionkinase binding

SPDYE1 PTK2B PKD1 SPDYE2 SPDYE21 PRMT1 SPDYE5 SPDYE18 TEX14 SPDYE2B SPDYE6 SPDYE16

3.07e-059696112GO:0019900
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH17 DNAH1 DNAH11

8.42e-0528613GO:0051959
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH17 DNAH1 DNAH11

1.28e-0370613GO:0003777
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.78e-1125576GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.22e-1028576GO:1904031
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.60e-0796576GO:0000079
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.32e-07100576GO:1904029
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

4.62e-07350579GO:0045860
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

SPDYE1 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.00e-06193577GO:0071902
GeneOntologyBiologicalProcesspositive regulation of kinase activity

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.55e-06405579GO:0033674
GeneOntologyBiologicalProcessregulation of protein kinase activity

HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.95e-066115710GO:0045859
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

HIPK3 SPDYE1 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

6.00e-06358578GO:0071900
GeneOntologyBiologicalProcesspostsynaptic specialization assembly

PTK2B NPTX1 PTPRD SPTBN2

6.55e-0644574GO:0098698
GeneOntologyBiologicalProcesspositive regulation of transferase activity

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

7.32e-06490579GO:0051347
GeneOntologyBiologicalProcessregulation of protein phosphorylation

PWP1 HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B INPP5J SPDYE6 SPDYE16

9.87e-0611335713GO:0001932
GeneOntologyBiologicalProcessregulation of kinase activity

HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.63e-056865710GO:0043549
GeneOntologyBiologicalProcessregulation of phosphorylation

PWP1 HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B INPP5J SPDYE6 SPDYE16

2.28e-0512265713GO:0042325
GeneOntologyBiologicalProcesspositive regulation of molecular function

HIPK3 SPDYE1 PTK2B TCAF1 RIPK3 LRRK2 SPDYE2 HIPK2 CARD11 SPDYE5 SPDYE2B ATP2A1 SPDYE6 SPDYE16

2.53e-0514305714GO:0044093
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.59e-057245710GO:0001934
GeneOntologyBiologicalProcesspostsynaptic specialization organization

PTK2B NPTX1 PTPRD SPTBN2

4.44e-0571574GO:0099084
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

4.87e-057805710GO:0042327
GeneOntologyBiologicalProcessregulation of postsynaptic specialization assembly

PTK2B PTPRD SPTBN2

4.97e-0526573GO:0099150
GeneOntologyBiologicalProcessregulation of transferase activity

HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

6.68e-058105710GO:0051338
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

PWP1 HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B INPP5J SPDYE6 SPDYE16

1.05e-0414215713GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

PWP1 HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B INPP5J SPDYE6 SPDYE16

1.06e-0414235713GO:0051174
GeneOntologyBiologicalProcesspostsynaptic density assembly

PTK2B NPTX1 PTPRD

1.13e-0434573GO:0097107
GeneOntologyBiologicalProcesspositive regulation of cell cycle

SPDYE1 NCAPD2 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.25e-04407577GO:0045787
GeneOntologyBiologicalProcesspostsynapse assembly

PTK2B NPTX1 PTPRD SPTBN2

1.27e-0493574GO:0099068
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.31e-048795710GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.31e-048795710GO:0010562
GeneOntologyBiologicalProcessregulation of protein modification process

PWP1 HIPK3 SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B INPP5J SPDYE6 SPDYE16

1.66e-0414885713GO:0031399
GeneOntologyBiologicalProcesspeptidyl-serine phosphorylation

PWP1 HIPK3 LRRK2 PKD1 HIPK2 INPP5J

1.99e-04307576GO:0018105
GeneOntologyBiologicalProcessJNK cascade

HIPK3 PTK2B LRRK2 HIPK2 PRMT1

2.16e-04198575GO:0007254
GeneOntologyBiologicalProcesspositive regulation of protein modification process

SPDYE1 PTK2B RIPK3 LRRK2 SPDYE2 HIPK2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.21e-049375710GO:0031401
GeneOntologyBiologicalProcesspeptidyl-serine modification

PWP1 HIPK3 LRRK2 PKD1 HIPK2 INPP5J

2.44e-04319576GO:0018209
GeneOntologyBiologicalProcessexcitatory synapse assembly

PTK2B NPTX1 PTPRD

2.79e-0446573GO:1904861
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

SPDYE1 PTK2B TRMT10C RIPK3 LRRK2 SPDYE2 HIPK2 PRMT1 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.34e-0414585712GO:0051247
GeneOntologyBiologicalProcesspostsynaptic density organization

PTK2B NPTX1 PTPRD

5.54e-0458573GO:0097106
GeneOntologyBiologicalProcessmitochondrion localization

LRRK2 PKD1 ATP2A1

7.06e-0463573GO:0051646
GeneOntologyBiologicalProcessregulation of JNK cascade

HIPK3 PTK2B HIPK2 PRMT1

1.02e-03161574GO:0046328
DomainSpy1

SPDYE1 SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16

7.10e-1611597PF11357
DomainSpeedy

SPDYE1 SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16

7.10e-1611597IPR020984
DomainPH_dom-spectrin-type

SPTBN5 SPTBN2

3.48e-049592IPR001605
DomainSCAN

ZSCAN9 ZFP69B ZNF287

8.17e-0458593PF02023
DomainSCAN_dom

ZSCAN9 ZFP69B ZNF287

8.17e-0458593IPR003309
DomainDynein_heavy_chain_D4_dom

DNAH1 DNAH11

8.71e-0414592IPR024317
DomainDynein_HC_stalk

DNAH1 DNAH11

8.71e-0414592IPR024743
DomainDynein_heavy_dom-2

DNAH1 DNAH11

8.71e-0414592IPR013602
DomainDHC_N2

DNAH1 DNAH11

8.71e-0414592PF08393
DomainMT

DNAH1 DNAH11

8.71e-0414592PF12777
DomainAAA_8

DNAH1 DNAH11

8.71e-0414592PF12780
DomainATPase_dyneun-rel_AAA

DNAH1 DNAH11

8.71e-0414592IPR011704
DomainAAA_5

DNAH1 DNAH11

8.71e-0414592PF07728
DomainDHC_fam

DNAH1 DNAH11

1.00e-0315592IPR026983
DomainDynein_heavy_dom

DNAH1 DNAH11

1.00e-0315592IPR004273
DomainDynein_heavy

DNAH1 DNAH11

1.00e-0315592PF03028
DomainActinin_actin-bd_CS

SPTBN5 SPTBN2

2.38e-0323592IPR001589
DomainSpectrin

SPTBN5 SPTBN2

2.38e-0323592PF00435
DomainACTININ_2

SPTBN5 SPTBN2

2.38e-0323592PS00020
DomainACTININ_1

SPTBN5 SPTBN2

2.38e-0323592PS00019
DomainSpectrin_repeat

SPTBN5 SPTBN2

3.77e-0329592IPR002017
DomainARM-type_fold

DNAJC13 LRRK2 INTS1 NCAPD2 HEATR1

4.30e-03339595IPR016024
DomainProt_kinase_dom

HIPK3 PTK2B RIPK3 LRRK2 HIPK2 TEX14

4.35e-03489596IPR000719
DomainPROTEIN_KINASE_DOM

HIPK3 PTK2B RIPK3 LRRK2 HIPK2 TEX14

4.53e-03493596PS50011
DomainSpectrin/alpha-actinin

SPTBN5 SPTBN2

4.58e-0332592IPR018159
DomainSPEC

SPTBN5 SPTBN2

4.58e-0332592SM00150
Domain-

DNAJC13 LRRK2 NCAPD2 HEATR1

5.31e-032225941.25.10.10
DomainQ_MOTIF

DDX50 DDX1

6.09e-0337592PS51195
DomainRNA_helicase_DEAD_Q_motif

DDX50 DDX1

6.09e-0337592IPR014014
DomainProtein_kinase_ATP_BS

HIPK3 PTK2B RIPK3 LRRK2 HIPK2

6.84e-03379595IPR017441
DomainKinase-like_dom

HIPK3 PTK2B RIPK3 LRRK2 HIPK2 TEX14

7.12e-03542596IPR011009
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH1 DNAH11

2.99e-0527323M47755
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH1 DNAH11

1.23e-0443323M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH1 DNAH11

1.41e-0445323M47670
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN5 SPTBN2

2.22e-0410322MM15112
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.89e-15961636272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.84e-141361615611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.76e-131761615574121
Pubmed

The DNA sequence of human chromosome 7.

KMT2C HIPK2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 DNAH11

1.03e-0644161812853948
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH17 DNAH1 DNAH11

1.84e-06146139373155
Pubmed

PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation.

RIPK3 PRMT1

3.03e-06261237005412
Pubmed

Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

DNAH1 DNAH11

3.03e-06261224360805
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE2 SPDYE6

9.07e-06361222763696
Pubmed

Uncommon somatic mutations in metastatic NUT midline carcinoma.

KMT2C DCC

9.07e-06361228967088
Pubmed

Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.

HIPK3 HIPK2

9.07e-06361229793420
Pubmed

Estrogenic induction of spermatogenesis in the hypogonadal mouse.

HIPK3 HIPK2

1.81e-05461210919273
Pubmed

Molecular motors: the driving force behind mammalian left-right development.

DNAH1 DNAH11

1.81e-05461210652513
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAH1 DNAH11

1.81e-05461218492703
Pubmed

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.

HIPK3 HIPK2

1.81e-05461234785661
Pubmed

Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).

HIPK3 HIPK2

1.81e-05461225630557
Pubmed

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.

NPTX1 PTPRD

3.02e-05561229024665
Pubmed

FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.

PRMT1 DDX1

3.02e-05561228040436
Pubmed

TDRD3 is an effector molecule for arginine-methylated histone marks.

PRMT1 CARD11

4.52e-05661221172665
Pubmed

Receptor protein tyrosine phosphatases are novel components of a polycystin complex.

PTPRD PKD1

4.52e-05661221126580
Pubmed

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.

HIPK3 HIPK2

4.52e-05661212529400
Pubmed

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.

HIPK3 HIPK2

4.52e-05661220579985
Pubmed

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.

HIPK3 HIPK2

4.52e-0566129748262
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH1 DNAH11

6.32e-0576129256245
Pubmed

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.

DNAH17 DNAH11

6.32e-05761233139725
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH17 DNAH11

6.32e-05761231178125
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

KMT2C PTPRD DNAH17 DCC DDX1

1.04e-0426561519240061
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PWP1 TRMT10C NPTX1 DNAJC13 DDX50 SPTBN2 INTS1 PRMT1 DDX1

1.07e-04108261938697112
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PWP1 MCM3AP SPTBN2 INTS1 NCAPD2 HEATR1 URB2

1.44e-0465361722586326
Pubmed

Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.

PKD1 DNAH11

1.65e-041161227272319
Pubmed

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.

HIPK3 HIPK2

1.97e-041261216537918
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN5 SPTBN2

2.33e-041361218796539
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

PWP1 SPTBN5 DNAJC13 DDX50 SPTBN2 DNAH1

2.33e-0449661631343991
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

FAT1 LRRK2 PKD1 NCAPD2 HIPK2 BSDC1 PRMT1 HEATR1 ZFP69B

2.55e-04121561915146197
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

HIPK3 FAT1 SPDYE2 HEATR1 SPDYE18 DNAH11

4.12e-0455261610737800
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

FAT1 DNAJC13 RIPK3 DDX50 CARD11

4.33e-0436161526167880
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN5 SPTBN2

4.55e-041861212119179
Pubmed

Directed proteomic analysis of the human nucleolus.

PWP1 DDX50 URB2 DDX1

4.97e-0420861411790298
Pubmed

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.

MCM3AP TEX14

5.08e-041961223666240
Pubmed

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.

PKD1 DNAH11

5.63e-042061217251353
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

KMT2C HIPK2 PRMT1 DDX1

6.13e-0422061435785414
Pubmed

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.

PKD1 DNAH11

6.22e-042161216291790
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

TCAF1 DDX50 INTS1 PRMT1 DDX1

6.43e-0439461527248496
Pubmed

F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.

PRMT1 DDX1

7.48e-042361224390425
Pubmed

Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.

PRMT1 DDX1

7.48e-042361218320585
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

PWP1 TCAF1 TRMT10C DDX50 NCAPD2 PRMT1 DDX1 ZNF287

8.83e-04115361829845934
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

PWP1 KMT2C DDX50 URB2

9.57e-0424861427926873
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PWP1 KMT2C TRMT10C DDX50 INTS1 NCAPD2 PRMT1 HEATR1 URB2

1.14e-03149761931527615
Pubmed

Primary Ciliary Dyskinesia

DNAH1 DNAH11

1.45e-033261220301301
Pubmed

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.

SPTBN5 SPTBN2

1.45e-033261223704327
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

TRMT10C NCAPD2 PRMT1 HEATR1 DDX1

1.60e-0348461531995728
Pubmed

A human MAP kinase interactome.

HIPK3 KMT2C MCM3AP SPTBN2 HIPK2

1.63e-0348661520936779
Pubmed

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

TRMT10C INTS1 PRMT1 DDX1

1.64e-0328761436180891
Pubmed

Toward a complete human genome sequence.

KMT2C TCAF1 HIPK2 CARD11 INPP5J SPDYE16

1.67e-037246169847074
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

HIPK3 PTK2B DNAH17 HIPK2 PRMT1 DNAH11

1.75e-0373061634857952
Cytoband7q22.1

SPDYE2 SPDYE2B SPDYE6

4.71e-041136137q22.1
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE21 SPDYE5 SPDYE18 SPDYE16

4.76e-04271614chr7q11
Cytoband1q43

WDR64 HEATR1

2.12e-03516121q43
CytobandEnsembl 112 genes in cytogenetic band chr1q43

WDR64 HEATR1

3.12e-0362612chr1q43
CytobandEnsembl 112 genes in cytogenetic band chr7q22

SPDYE2 SPDYE2B SPDYE6

3.14e-03219613chr7q22
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6

4.68e-1112435756
GeneFamilyDyneins, axonemal

DNAH17 DNAH1 DNAH11

8.33e-0617433536
GeneFamilyEF-hand domain containing|Spectrins

SPTBN5 SPTBN2

1.15e-0474321113
GeneFamilyDEAD-box helicases

DDX50 DDX1

4.48e-0342432499
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

PTK2B HEATR1

6.54e-0351432870
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 DNAH17 LRRK2 HIPK2 SLC35F4 DNAH11

1.38e-07176606327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

NPTX1 FAM180B PTPRD SPTBN2 ZFP69B

2.34e-06158605ab05f6d7968ccd6d3826cd71b763dbedc83822c3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PTPRD LRRK2 SLC35F4 DNAH11

4.68e-061826055e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 PTPRD DCC DNAH1 DNAH11

4.93e-06184605ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 PTPRD DCC DNAH1 DNAH11

4.93e-061846052cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 PTPRD DCC DNAH1 DNAH11

4.93e-061846052b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_plasma|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTK2B WDR64 HIPK2 TEX14 DCC

7.04e-06198605567fcf882c8612356946240843525b786f3c8dbe
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B CDR1 NPTX1 SPTBN2

5.69e-0515560472a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B NPTX1 MAB21L4 SLC35F4

7.59e-051676043dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B NPTX1 MAB21L4 SLC35F4

7.59e-0516760495b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B NPTX1 MAB21L4 SLC35F4

7.59e-051676049480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCell356C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FANCE SPTBN5 SLC66A2 DNAH17

8.32e-051716043d26ef58fe5231373d7df9ac79d225546918cf82
ToppCell356C-Lymphocytic-ILC-ILC-2|ILC / Donor, Lineage, Cell class and subclass (all cells)

FANCE SPTBN5 SLC66A2 DNAH17

8.51e-051726044977e1f4deae781750e27a8054deccd336cfb74a
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAB21L4 CARD11 ATP2A1 XKRX

8.70e-051736044f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAB21L4 CARD11 ATP2A1 XKRX

8.70e-051736049bbea566964281f47bf75d665b7d69ba8326e207
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PTPRD LRRK2 DCC

9.93e-0517960458ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTK2B CDR1 PTPRD DCC

1.01e-041806045391d23817f5cc88a0871ddb98968897c839f464
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT1 PTPRD TEX14 FAM149A

1.01e-04180604b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 DNAH17 LRRK2 HIPK2

1.08e-0418360492fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT1 NPTX1 LRRK2 FAM149A

1.13e-0418560498b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CDR1 PTPRD LRRK2 SLC35F4

1.13e-041856045a0340c25196453f19e424d346efbf66d2c53ac3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PTPRD LRRK2 DCC

1.15e-04186604f28d72b47624b69a580b4429e2be560a26898591
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PTPRD LRRK2 DCC

1.17e-041876049d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B CDR1 NPTX1 SPTBN2

1.17e-04187604e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B CDR1 NPTX1 SPTBN2

1.17e-0418760424cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B CDR1 NPTX1 SPTBN2

1.17e-041876042f153b203fe79f206319603cf94d3a03ab49a05d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PTPRD LRRK2 DCC

1.22e-041896043b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 LRRK2 HIPK2 DNAH11

1.25e-04190604b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTK2B PTPRD LRRK2 SLC35F4

1.25e-041906041bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PTPRD LRRK2 DCC

1.27e-041916041cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTK2B PTPRD LRRK2 SLC35F4

1.30e-0419260425460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B CDR1 NPTX1 SPTBN2

1.33e-04193604be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B CDR1 NPTX1 SPTBN2

1.33e-041936040c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B CDR1 NPTX1 SPTBN2

1.33e-041936048689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

WDR64 HIPK2 TEX14 DCC

1.41e-04196604fd18a9ae8401121ae276adff1a85d5f938e2df91
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

TCAF1 NPTX1 PTPRD DCC

1.52e-04200604e9eb348a66011d8aace4331f84690ae27cb0d061
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-Neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

TCAF1 NPTX1 PTPRD DCC

1.52e-04200604ddac952ad1d46021c2d17d816de9bc31730a0941
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Cbln4_(Neuron.Slc17a7.Cbln4)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SPTBN5 WDR64 XKRX

1.66e-0479603397f3a1f5fa67dd0b2ed53ebcad74dedf0498fce
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Cbln4_(Neuron.Slc17a7.Cbln4)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

SPTBN5 WDR64 XKRX

1.66e-0479603d24301b6694f64e8bb1b5f0673f653d25d45d3eb
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2C FAT1 DCC

8.23e-0545553DOID:3748 (is_implicated_in)
DiseaseColorectal Carcinoma

KMT2C FAT1 SLC66A2 PTPRD MCM3AP SPTBN2 DCC

3.15e-04702557C0009402
DiseaseSezary Syndrome

KMT2C CARD11

1.16e-0327552C0036920
DiseasePrimary ciliary dyskinesia

DNAH1 DNAH11

2.06e-0336552cv:C0008780
DiseaseMalignant Head and Neck Neoplasm

FANCE FAT1

3.07e-0344552C0278996
DiseasePrimary Ciliary Dyskinesia

DNAH1 DNAH11

3.49e-0347552C4551720

Protein segments in the cluster

PeptideGeneStartEntry
LIEMDDPAWLEFLQV

URB2

986

Q14146
PQELLWLDELMPEEE

SLC4A9

931

Q96Q91
WLDELMPEEERSIPE

SLC4A9

936

Q96Q91
WEEEEEELMGISPIS

BSDC1

221

Q9NW68
WLPDIFIIELMDVDK

HTR3E

121

A5X5Y0
IVLDGDIDPMWIESL

DNAH11

2256

Q96DT5
MAWLEDVDFLEDVPL

CDR1

1

P51861
LPAEEGKTLWELVIE

ATP2A1

41

O14983
LPVEKVDIIISEWMG

PRMT1

151

Q99873
ELVLIEWGNNPMEIL

NPTX1

281

Q15818
VREDLPEGTVIMWLE

FAT1

936

Q14517
MEVPLWVDAEALLIE

MAB21L4

81

Q08AI8
PIDDWIMETISGDRL

DCC

991

P43146
VEWSLGVCQMEEPLL

KMT2C

256

Q8NEZ4
EIILGLPFCEAIDMW

HIPK2

371

Q9H2X6
LDLLWLEEVVPMMGV

ENTPD7

586

Q9NQZ7
GLLVDWLEMLDPEVV

INTS1

1616

Q8N201
LWEVEEMLFEGKVNP

FAM149A

286

A5PLN7
VMEIPWDDLIALCIN

MCM3AP

1736

O60318
PEIAQAVEEMDWLLP

DDX1

11

Q92499
AVEEMDWLLPTDIQA

DDX1

16

Q92499
SLMEEWFPGLLEIDI

LRRK2

1786

Q5S007
ILVKLMEWEPGREEI

HIPK3

771

Q9H422
IEELAELREWMKGIP

DNAH1

861

Q9P2D7
IILDGDIDPMWIESL

DNAH17

2201

Q9UFH2
LWGDIMELEAPLEES

DDX50

6

Q9BQ39
QRWGLLSMPVDEEVE

DNAJC13

341

O75165
ELMLDRGIPVELWAH

HEATR1

756

Q9H583
LMLGQILELPWKEET

FANCE

436

Q9HB96
GIIEEEPTWIIMELY

PTK2B

491

Q14289
GFTIIVMPLELEWLD

SLC22A7

211

Q9Y694
VMPLELEWLDVEHRT

SLC22A7

216

Q9Y694
EPDMWGSVEELLRVV

CARD11

1121

Q9BXL7
EDMVWRTEGLLPLEE

PKD1

3021

P98161
KPWESPDEMELDELL

PTPRD

1156

P23468
APEVMFELLWAGLEL

FAM180B

46

Q6P0A1
DPGAVVDLLEMWDEL

SPATA6L

66

Q8N4H0
MQEILTDDIPWKGLD

TEX14

446

Q8IWB6
MDIKPVDWEEIGGLE

SPATA5L1

456

Q9BVQ7
LENPEPLLRLWDEVM

TCAF1

681

Q9Y4C2
VERGVVWEEVLIMLP

SKIV2L

431

Q15477
GFLLMLLPEEWDEIT

SLC35F4

466

A4IF30
EPEEIWVAEMLCGLK

SPDYE2B

166

A6NHP3
MEELENWLEPIEVEL

SPTBN5

2796

Q9NRC6
MQEELAWETDGLLPL

ANKDD1A

1

Q495B1
AVLDPEEEWEAMLPE

NCAPD2

471

Q15021
DDMPLVRLEVADEWV

INPP5J

736

Q15735
GNMTPVIEVWDLDIV

PWP1

211

Q13610
ILEEPWMVIKEILEG

ZNF287

221

Q9HBT7
TMRLWNIEEIDEIPL

WDR88

386

Q6ZMY6
DVEDEILWVTERLPM

SPTBN2

1496

O15020
MWAVLAGREVELPTE

RIPK3

211

Q9Y572
EPEEIWVVEMLCGLK

SPDYE16

126

A6NNV3
EPEEIWVAEMLCGLK

SPDYE18

166

P0DV79
EPEEIWVAEMLCGLK

SPDYE21

166

A0A494C086
EPEEIWVAEMLCGLK

SPDYE2

166

Q495Y8
EPEEIWVAEMLCGLK

SPDYE5

166

A6NIY4
EPEEIWVAEMLCGLK

SPDYE6

166

P0CI01
VLAPEPEEIWVAEML

SPDYE1

121

Q8NFV5
LLEQGKEPWMVDREL

ZNF829

86

Q3KNS6
LEKGEEPWLMERDIS

ZFP69B

126

Q9UJL9
EPEEIWVAEMLCGLK

nan

126

A6NJR5
LGVQVPEAWEELLTM

ZSCAN9

11

O15535
MLIDGEEVLIEWEVG

XKRX

141

Q6PP77
EFIEMWRLLGREVPE

TRMT10C

96

Q7L0Y3
MEAEGLDWLLVPLHQ

SLC66A2

1

Q8N2U9
GKEDDIYLMVIWELP

WDR64

581

B1ANS9