Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptidase activity

ADAMTS16 AGBL4 TMPRSS5 IHH ADAMTS9 PRSS36 PRSS22

2.04e-04654387GO:0008233
DomainTSP_1

ADAMTS16 PAPLN SEMA5A THSD7A ADAMTS9

1.49e-0763375PF00090
DomainTSP1

ADAMTS16 PAPLN SEMA5A THSD7A ADAMTS9

1.75e-0765375SM00209
DomainTSP1_rpt

ADAMTS16 PAPLN SEMA5A THSD7A ADAMTS9

1.75e-0765375IPR000884
DomainTSP1

ADAMTS16 PAPLN SEMA5A THSD7A ADAMTS9

1.75e-0765375PS50092
DomainPRKG1_interact

PPP1R12A PPP1R12C

1.14e-053372IPR031775
DomainPRKG1_interact

PPP1R12A PPP1R12C

1.14e-053372PF15898
DomainMYPT1/MYPT2_chordates

PPP1R12A PPP1R12C

1.14e-053372IPR017401
DomainADAM_spacer1

ADAMTS16 PAPLN ADAMTS9

1.23e-0523373IPR010294
DomainADAM_spacer1

ADAMTS16 PAPLN ADAMTS9

1.23e-0523373PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS16 PAPLN ADAMTS9

1.41e-0524373IPR013273
DomainPLAC

ADAMTS16 PAPLN

3.42e-0414372PF08686
DomainVWC_out

JAG2 KCP

6.39e-0419372SM00215
DomainPLAC

ADAMTS16 PAPLN

6.39e-0419372IPR010909
DomainPLAC

ADAMTS16 PAPLN

6.39e-0419372PS50900
DomainTRYPSIN_SER

TMPRSS5 PRSS36 PRSS22

7.47e-0490373IPR033116
DomainTRYPSIN_HIS

TMPRSS5 PRSS36 PRSS22

1.10e-03103373IPR018114
DomainTRYPSIN_SER

TMPRSS5 PRSS36 PRSS22

1.20e-03106373PS00135
DomainTRYPSIN_HIS

TMPRSS5 PRSS36 PRSS22

1.23e-03107373PS00134
DomainPeptidase_S1A

TMPRSS5 PRSS36 PRSS22

1.44e-03113373IPR001314
DomainTRYPSIN_DOM

TMPRSS5 PRSS36 PRSS22

1.52e-03115373PS50240
DomainTryp_SPc

TMPRSS5 PRSS36 PRSS22

1.59e-03117373SM00020
DomainTrypsin

TMPRSS5 PRSS36 PRSS22

1.75e-03121373PF00089
DomainTrypsin_dom

TMPRSS5 PRSS36 PRSS22

1.75e-03121373IPR001254
DomainPeptidase_S1_PA

TMPRSS5 PRSS36 PRSS22

1.84e-03123373IPR009003
DomainVWFC_1

JAG2 KCP

2.31e-0336372PS01208
DomainVWC

JAG2 KCP

2.57e-0338372SM00214
DomainVWFC_2

JAG2 KCP

2.57e-0338372PS50184
DomainPeptidase_M12B_N

ADAMTS16 ADAMTS9

2.70e-0339372IPR002870
DomainPep_M12B_propep

ADAMTS16 ADAMTS9

2.70e-0339372PF01562
DomainDISINTEGRIN_1

ADAMTS16 ADAMTS9

2.84e-0340372PS00427
DomainADAM_MEPRO

ADAMTS16 ADAMTS9

2.84e-0340372PS50215
DomainDISINTEGRIN_2

ADAMTS16 ADAMTS9

2.84e-0340372PS50214
DomainReprolysin

ADAMTS16 ADAMTS9

2.84e-0340372PF01421
DomainPeptidase_M12B

ADAMTS16 ADAMTS9

2.84e-0340372IPR001590
DomainCYSTEINE_SWITCH

ADAMTS16 ADAMTS9

2.98e-0341372PS00546
DomainDisintegrin_dom

ADAMTS16 ADAMTS9

2.98e-0341372IPR001762
DomainVWF_dom

JAG2 KCP

3.13e-0342372IPR001007
DomainPept_M10_metallopeptidase

ADAMTS16 ADAMTS9

3.28e-0343372IPR001818
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS16 SEMA5A THSD7A ADAMTS9

5.11e-0739244M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS16 SEMA5A THSD7A ADAMTS9

5.11e-0739244MM15165
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS16 SEMA5A THSD7A ADAMTS9

4.89e-0668244M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS16 SEMA5A THSD7A ADAMTS9

3.19e-05109244MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS16 SEMA5A THSD7A ADAMTS9

3.43e-05111244M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS16 SEMA5A THSD7A ADAMTS9

9.21e-05143244M27275
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS16 SEMA5A THSD7A ADAMTS9

7.76e-04250244M27554
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS16 PAPLN SEMA5A THSD7A ADAMTS9

2.53e-087540520637190
Pubmed

Inhibition of RhoA-mediated SRF activation by p116Rip.

PPP1R12A PPP1R12C

7.73e-06440216243315
Pubmed

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.

ADAMTS16 ADAMTS9

7.73e-06440216507336
Pubmed

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells.

ADAMTS16 ADAMTS9

1.29e-05540222562232
Pubmed

PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.

PPP1R12A PPP1R12C

1.29e-05540212923170
Pubmed

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

PPP1R12A PPP1R12C

8.45e-051240224785407
Pubmed

ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.

ADAMTS16 ADAMTS9

1.53e-041640230579834
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CCDC142 JAG2 PAPLN TNRC18 GRIN2D SH2B3 AHDC1

2.39e-04110540735748872
Pubmed

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

JAG2 IHH

2.94e-042240221750033
Pubmed

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.

JAG2 IHH

5.13e-042940224971735
Pubmed

EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.

JAG2 IHH

5.13e-042940224909139
Pubmed

Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.

JAG2 SMPD1

5.50e-043040219054571
Pubmed

pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.

JAG2 IHH

5.50e-043040217257418
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

AGBL4 SMG7

8.83e-043840236674791
Pubmed

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling.

SP6 IHH

9.79e-044040217199044
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

AGBL4 MGAT3 MAP7 CORO7 PPP1R12A PPP1R12C SLC4A1

1.11e-03143140737142655
Cytoband16p13.3

CORO7 METTL26 PRSS22

1.27e-0324440316p13.3
GeneFamilyProteases, serine

TMPRSS5 PRSS36 PRSS22

5.13e-0563213738
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS16 ADAMTS9

2.17e-041921250
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R12A PPP1R12C

1.85e-02181212694
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A GRIN2D THSD7A DSEL LINC01561

7.63e-0719140506760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A GRIN2D THSD7A DSEL LINC01561

7.83e-071924056a252e298f8a454623fa9c1c893a7a45a886d694
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A DSEL LINC01561

1.94e-051784043c973aac16988e88f5677d3d695dd772ccfd6570
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A DSEL LINC01561

2.07e-0518140435bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A THSD7A DSEL LINC01561

2.07e-0518140470eff83dd85691e977972c660731394d2fcf5cdf
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3-6_VIP_KCTD13|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A GRIN2D THSD7A DSEL

2.16e-05183404f06c06c75aab55fa8c803665afaa399446aec5af
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A DSEL LINC01561

2.21e-0518440432473dbdb2de66391157c5814ef34e790806e4f2
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs|metastatic_Lymph_Node / Location, Cell class and cell subclass

PAPLN SEMA5A ADAMTS9 KIF25-AS1

2.35e-05187404e04fb35f2f5b120659d06b5ae427ab1ec56d5c36
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A DSEL LINC01561

2.40e-051884046ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A DSEL LINC01561

2.40e-05188404c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS16 AGBL4 PAPLN SEMA5A

2.55e-051914041cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A DSEL LINC01561

2.60e-05192404025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCellSepsis-Int-URO-Others-RBC|Int-URO / Disease, condition lineage and cell class

PAPLN SEMA5A MAP7 DSEL

2.94e-0519840429203aaa5c1844f72289e03f585cd5e7fc498a9a
ToppCellSepsis-Int-URO-Others|Int-URO / Disease, condition lineage and cell class

PAPLN SEMA5A MAP7 DSEL

2.94e-0519840467f721ea8e60042317ba12efd584f56b07cfb29d
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA5A TMPRSS5 MGAT3 ERVMER34-1

3.00e-051994042b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_Myelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTS16 TMPRSS5 SMPD1 MGAT3

3.00e-051994044e4bdcd2e8b518156d5ebd294804180acaa3566b
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A THSD7A DSEL LINC01561

3.05e-0520040448303e499251d6754cfa991dc2d96c5563b2123c
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1-L2-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A THSD7A DSEL LINC01561

3.05e-05200404f922f9f223cbfed71b8e3115b16b51dc4d7b66b8
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A GRIN2D THSD7A LINC01561

3.05e-052004047e51715525fdb001b7042b2bfcb9de81ecb5e4ee
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A THSD7A DSEL LINC01561

3.05e-052004044802dd6cae84b41746227a5d1aa1c9b858495e36
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A THSD7A DSEL LINC01561

3.05e-05200404c4e08cf539c12bb7c61be6d44b4f074bb460f526
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A THSD7A DSEL LINC01561

3.05e-05200404913487e065dd580c9cbcbb3c3fc76a8d446f8856
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A GRIN2D THSD7A LINC01561

3.05e-0520040475649534a98bc738fca62d071de0978dc61eb24f
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

1.54e-04116403a07f16917c66ce25f23ebef350d693cc4c324075
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)|Thalamus / BrainAtlas - Mouse McCarroll V32

SP6 PPP1R12A PPP1R12C

1.96e-04126403333f83f9ba64d46f22fee328d0a691fd5818bdac
ToppCellThalamus-Endothelial-MURAL|Thalamus / BrainAtlas - Mouse McCarroll V32

SP6 PPP1R12A PPP1R12C

1.96e-04126403cf571f36761da3540fb445de89d555cbce8a47ab
ToppCellControl-Epithelial_alveolar-AT_1-AT2_Progenitor|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PAPLN CA14 PRSS22

2.79e-0414240394e277f038f4006d99ff50222b0f5cf89bc3d46d
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar-Club_cell|E18.5-samps / Age Group, Lineage, Cell class and subclass

MGAT3 GRIN2D SLC4A1

3.21e-0414940382edfecb7981d8c336cf9da7aa7e2b3f7a017a3f
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar|E18.5-samps / Age Group, Lineage, Cell class and subclass

MGAT3 GRIN2D SLC4A1

3.21e-0414940314a01ae540db8a350ea26a350b2e6ce6c07639d9
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

AGBL4 THSD7A PRSS22

3.75e-041574035aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CA14 PRSS36 PRSS22

3.75e-041574039665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCelldroplet-Fat-SCAT-30m-Hematologic-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC142 PAPLN SLC4A1

3.96e-0416040367ee7a314d7d4d3ea206e0158083f36f6dd7e80b
ToppCelldroplet-Fat-SCAT-30m-Hematologic-erythroblast|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC142 PAPLN SLC4A1

3.96e-04160403fc76337ad766c859db390ef8b6fb9caeaace3a56
ToppCelldroplet-Fat-SCAT-30m-Hematologic|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC142 PAPLN SLC4A1

3.96e-04160403759749f708c3a2b36692d42499f19aff937e592f
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERVMER34-1 SLC4A1 PRSS22

4.03e-041614030d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-hematologic-erythrocytic-erythrocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TMPRSS5 MGAT3 SLC4A1

4.11e-0416240325a11e4c6304324310b33a33331ebc812d045d4a
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

AGBL4 MAP7 PRSS22

4.25e-0416440385f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

AGBL4 MAP7 PRSS22

4.25e-04164403144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 TNRC18 MAP7

4.41e-04166403a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCellfacs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 TNRC18 MAP7

4.41e-041664030f641302a6b71c4badaaf20f51162bfc2386b167
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 SEMA5A THSD7A

4.49e-04167403cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SP6 THSD7A SMG7

4.49e-04167403774f3264318b002d0df5d06d41d645366038d0bf
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS16 AGBL4 PAPLN

4.56e-04168403a086c306be430adf0632ba53e98cd8014d2de330
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 SEMA5A THSD7A

4.64e-0416940330141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SP6 MAP7 PRSS22

4.81e-041714033a2fefcb62e9d47ae6b3a946c45d3f2dd32c576c
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SP6 MAP7 PRSS22

4.81e-041714033ef44a5e3e8f81424f1e9aa302860b6688a549b8
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

SP6 THSD7A ADAMTS9

4.89e-04172403c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A THSD7A DSEL

5.06e-04174403fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A THSD7A LINC01561

5.06e-041744038d8cf8ad17dcc364f867e36b10834a21c0e36ad2
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SP6 MAP7 IHH

5.06e-04174403ca067e8ec55bbc3deafc09f08bc13af08364d165
ToppCellBAL-Mild-Myeloid-MoAM-MoAM4|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

KCP PAPLN SLC4A1

5.06e-041744039191f6abb37ca65da5105f91e21689d11ec1059b
ToppCellBAL-Mild-Myeloid-MoAM-MoAM4-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KCP PAPLN SLC4A1

5.06e-04174403fe105550a43b935affc73e32796115d20328a2f8
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A GRIN2D THSD7A

5.14e-04175403e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A THSD7A LINC01561

5.14e-041754035a9160a9d05e01d945e77fd81bb0bd87139545cd
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A LINC01561

5.23e-0417640323f930dac5247ea6d4124da33933d61ad6e089af
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCP GRIN2D THSD7A

5.23e-0417640395d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS16 AGBL4 PAPLN

5.40e-04178403544379f5a6145429762258d426b876bb36c112f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SH2B3 KIF25-AS1 PRSS36

5.40e-0417840324e8c62060455159235985f456af0c5023a7f3f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SH2B3 KIF25-AS1 PRSS36

5.40e-041784034f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

JAG2 THSD7A ADAMTS9

5.49e-041794031ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A DSEL

5.49e-0417940301302505816f272243659e20d751b61a198a2fc0
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

JAG2 THSD7A ADAMTS9

5.49e-041794032a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A GRIN2D LINC01561

5.49e-041794035bf191bdc0c32bce83ab5c38f0616e209e420e55
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-B_memory-0|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MGAT3 FITM1 MAP7

5.49e-04179403fce1ba53815145f6248d4e90aedca3dad84e33e4
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SP6 PAPLN ADAMTS9

5.49e-04179403dfd5b25f2a6a5a8bf4714f1516cb0997de72b06f
ToppCellRA-07._Pericyte|RA / Chamber and Cluster_Paper

SEMA5A THSD7A ADAMTS9

5.67e-041814038dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEMA5A THSD7A LINC01561

5.67e-041814037846c7b33d1b89364c5a704edaa86520db731c89
ToppCellControl-Epithelial_alveolar-AT_1-AT1-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

5.76e-04182403a95956ce4adccb34cc0c47ebfa1878ce4617904e
ToppCellRA-07._Pericyte|World / Chamber and Cluster_Paper

SEMA5A THSD7A ADAMTS9

5.76e-041824032075efeae633550fb2eb026d0dfd741c8252482e
ToppCellControl-Epithelial-Basal|World / Disease state, Lineage and Cell class

JAG2 SEMA5A PRSS22

5.76e-04182403759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D DSEL LINC01561

5.76e-041824033d7a8d2ee2137b098248597058974ef5ae09c19e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS16 SEMA5A ADAMTS9

5.76e-041824035e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellControl-Epithelial-Basal|Control / Disease state, Lineage and Cell class

JAG2 SEMA5A PRSS22

5.76e-04182403caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 THSD7A ADAMTS9

5.76e-041824030346f81bbb1f309f3e9d063b20547d548d09472c
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

5.76e-041824031e2149b222a3e9f64841aed45288a6f29394e7b0
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

AGBL4 MAP7 THSD7A

5.76e-041824039d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

5.76e-04182403d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

5.85e-0418340306ac66726ec53db810ebb90ec69cfdb903da53f6
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

5.85e-041834035f2db95d44b7de68779de098892892af540fd431
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A PPP1R12A PPP1R12C

5.85e-041834038d45dff06a199b1369576657f7f9dc0249c5f841
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A ADAMTS9

5.85e-041834035e361be3ae3fe05098968e58427630127bd12675
ToppCellCOPD-Epithelial-Basal|COPD / Disease state, Lineage and Cell class

JAG2 SEMA5A MAP7

5.85e-041834030f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A PPP1R12A PPP1R12C

5.85e-04183403421265fa15d5a028cb567bb0904e670473ef102b
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

5.95e-04184403cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCP PAPLN SEMA5A

5.95e-04184403102b6f621a5b551e622f97b12d787c080b052a72
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

5.95e-04184403157a3d00165bb4a8c52c3e63ae57d9cf57500be7
ToppCellwk_20-22-Epithelial-PNS-intermediate_Schwann|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SEMA5A THSD7A ADAMTS9

5.95e-041844034e3ba64692868563a579902aa9c6f88cab5bce26
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1-AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

6.04e-041854033bef59cc0aa939d2a7e52f0f6c61bc00528fe50b
ToppCellControl-Epithelial_alveolar|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP7 PRSS36 PRSS22

6.04e-041854033937e026add96a396122139daf8011cfbc60e75c
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KCP SEMA5A ADAMTS9

6.04e-04185403a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A ADAMTS9 PPP1R12A

6.04e-0418540335d39a1d04c871edcfb749653538dc5fd0054281
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 THSD7A SH2B3

6.04e-04185403602536a3308a848f106adcb0a83530997440c8f4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS16 AGBL4 PRSS22

6.14e-04186403d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 THSD7A PPP1R12C

6.14e-04186403bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCP AGBL4 SEMA5A

6.14e-04186403b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN2D THSD7A LINC01561

6.23e-04187403ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

JAG2 THSD7A ADAMTS9

6.23e-0418740340ffc06a3e3251d9b12da390210d3e045af7537a
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS5 MGAT3 IHH

6.23e-041874036f7f293c9cf35261e0e3614e46ec1fb00a701b63
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

AGBL4 MAP7 THSD7A

6.23e-04187403d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 THSD7A ADAMTS9

6.23e-0418740325efb82afe863a853ecdd781ad89026c993aaa67
Diseasemajor depressive disorder

AGBL4 TMPRSS5 THSD7A

8.94e-04155363MONDO_0002009
Diseasekynurenine measurement

THSD7A SH2B3

1.04e-0339362EFO_0008529
Diseasecigarettes per day measurement

AGBL4 TMPRSS5 CA14 THSD7A

1.94e-03438364EFO_0006525
DiseaseCalcium channel blocker use measurement

SP6 SH2B3 AHDC1

2.22e-03213363EFO_0009930
Diseaserheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement

KCP SH2B3

2.70e-0363362EFO_0000685, EFO_0007791, EFO_0009459
Diseasesclerosing cholangitis

KCP SH2B3

2.96e-0366362EFO_0004268
Diseasecoronary artery disease

SP6 SEMA5A THSD7A CORO7 SH2B3 AHDC1

2.98e-031194366EFO_0001645

Protein segments in the cluster

PeptideGeneStartEntry
NGAWGRPHLSHLTFW

SLC4A1

91

P02730
GHIPPGHCLKSWSWN

SMPD1

426

P17405
HSFTPWIQAHGGWEG

BCL2L12

306

Q9HB09
WEVHCWPSGTSGGTP

CCDC142

41

Q17RM4
AEWAGDKGGGWAPHH

AHDC1

766

Q5TGY3
GPKPTHGHWSDWSSW

ADAMTS16

581

Q8TE57
KHNRWSWGGSLHGSP

MAP7

156

Q14244
WSLGSPLHFAGWHCS

MGAT3

406

Q09327
SCWSRGTPFPHGSSW

JAG2

871

Q9Y219
KGHDGHRTPTWWLTG

ERVMER34-1

271

Q9H9K5
SIHLPPNTHCWISGW

PRSS22

166

Q9GZN4
AGCVPATDPHSWWAG

CORO7

361

P57737
QGLTELAWGTWPHSH

KIF25-AS1

36

Q9Y6Z4
HWGEPKTWYGVPSHA

KDM5A

496

P29375
GTWPWQVSLHHGGGH

PRSS36

56

Q5K4E3
THACPHDAAWSTGPW

ADAMTS9

1436

Q9P2N4
SWYHQPWSPGSPGHG

FITM1

266

A5D6W6
GLGGHWACSEPSPWT

FAM25E

51

A8MYX2
HWLDPSPWVHPTLHG

AGBL4

291

Q5VU57
WHWPEDSHPGLAGAS

DALRD3

256

Q5D0E6
AHLGPSEAQHWSHGW

GNRH2

16

O43555
HWTYEGPHGQDHWPA

CA14

21

Q9ULX7
HLGGIWAGHSPWTVI

RTL8C

166

O15255
WIDGWRSFNPGHEHP

DSEL

456

Q8IZU8
LFHSLAWGSWTPGEG

IHH

366

Q14623
APLHLDVTWGWEHWG

METTL26

81

Q96S19
RDGDGWTPLHAAAHW

PPP1R12C

256

Q9BZL4
EHPCTVYHWQTGPWG

THSD7A

691

Q9UPZ6
HWEHGQEWTTPGDPC

KCP

261

Q6ZWJ8
WHQASTPSGTWTGHG

SMG7

1071

Q92540
SWFRPTHPGAEDGSW

SP6

106

Q3SY56
THPGAEDGSWWDLHP

SP6

111

Q3SY56
WDLHPGTSWMDLPHT

SP6

121

Q3SY56
GHFGVWSPWTPCTHT

SEMA5A

541

Q13591
WEKPSGWGHLHAAVT

LINC01561

81

Q8N1V8
WSADPAAHLATHPWL

TNRC18

791

O15417
RPSPGFSWSHGSWSD

PAPLN

301

O95428
RCWVSGWGHTHPSHT

TMPRSS5

341

Q9H3S3
LPHWDSESLPHWGSE

SH2B3

481

Q9UQQ2
WSVDVGRHPGWTGHV

RALGAPB

1201

Q86X10
GRHPGWTGHVSTSWS

RALGAPB

1206

Q86X10
DTAHPHGGPSWWASL

PVRIG

246

Q6DKI7
HGGPSWWASLPTHAA

PVRIG

251

Q6DKI7
WWASLPTHAAHRPQG

PVRIG

256

Q6DKI7
DGWTPLHAAAHWGKE

PPP1R12A

231

O14974
SCSHDGLDGGWWAPP

GRIN2D

1196

O15399