Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 OR2M2 OR4C11 OR5G3 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 GRM1 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 CXCR6 GPR158 OR4A16 FSHR TAS1R2 OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

3.48e-3088410242GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 TRPA1 OR2M2 OR4C11 OR5G3 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 GRM1 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 CXCR6 GPR158 OR4A16 FSHR TAS1R2 OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

6.54e-24135310243GO:0004888
GeneOntologyMolecularFunctionolfactory receptor activity

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

3.77e-2243110227GO:0004984
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

2.19e-1146510218GO:0046873
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

9.65e-1066410219GO:0008324
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

2.68e-0962710218GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB SLC22A1 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

2.89e-0979310220GO:0015075
GeneOntologyMolecularFunctiontransmembrane transporter activity

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 ABCA13 PIEZO1 TRPC5 TMEM175 SLC1A1 ABCA10 SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB SV2B SLC22A1 PKD2 SV2C CACNA1I TMCO3 SLC12A7 ATP4B

4.19e-09118010224GO:0022857
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB SLC22A1 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

8.42e-0975810219GO:0015318
GeneOntologyMolecularFunctiontransporter activity

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 ABCA13 PIEZO1 TRPC5 TMEM175 SLC1A1 ABCA10 SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB SV2B SLC22A1 PKD2 SV2C CACNA1I TMCO3 SLC12A7 ATP4B

2.31e-08128910224GO:0005215
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC12A6 ATP7A ATP7B SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 TMCO3 SLC12A7 ATP4B

4.46e-0830110212GO:0022853
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC12A6 ATP7A ATP7B ABCA13 SLC1A1 ABCA10 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 TMCO3 SLC12A7 ATP4B

1.42e-0747710214GO:0022804
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A6 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 SLC12A7

1.73e-071191028GO:0015294
GeneOntologyMolecularFunctionodorant binding

OR5P3 OR5D16 OR9G1 OR5G3 OR5B2 OR5K4 OR8B8 OR5L2

2.85e-071271028GO:0005549
GeneOntologyMolecularFunctionsymporter activity

SLC12A6 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 SLC12A7

1.02e-061501028GO:0015293
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 PKD2 CACNA1I

2.72e-061711028GO:0015081
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1

3.65e-06811026GO:0015370
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC12A6 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 TMCO3 SLC12A7

2.10e-052961029GO:0015291
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNMB2 SLC12A6 TMEM175 PKD2 TMCO3 SLC12A7 ATP4B

2.39e-051671027GO:0015079
GeneOntologyMolecularFunctionP-type divalent copper transporter activity

ATP7A ATP7B

2.58e-0521022GO:0043682
GeneOntologyMolecularFunctionP-type monovalent copper transporter activity

ATP7A ATP7B

2.58e-0521022GO:0140581
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC1A1 SLC6A9 SLC10A1 SLC10A2

2.97e-05351024GO:0005343
GeneOntologyMolecularFunctionchannel activity

KCNMB2 SLC12A6 TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 CLCNKB PKD2 CACNA1I SLC12A7

7.69e-0552510211GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNMB2 SLC12A6 TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 CLCNKB PKD2 CACNA1I SLC12A7

7.82e-0552610211GO:0022803
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A6 SLC22A1 SLC12A7

2.13e-04231023GO:0015377
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP7A ATP7B ABCA13 ABCA10 ATP4B

2.42e-041091025GO:0042626
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A6 SLC22A1 SLC12A7

3.09e-04261023GO:0015296
GeneOntologyMolecularFunctionG protein-coupled chemoattractant receptor activity

CXCR6 CCR4 CMKLR1

3.09e-04261023GO:0001637
GeneOntologyMolecularFunctionchemokine receptor activity

CXCR6 CCR4 CMKLR1

3.09e-04261023GO:0004950
GeneOntologyMolecularFunctionbile acid:sodium symporter activity

SLC10A1 SLC10A2

3.82e-0461022GO:0008508
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A6 SLC1A1 CLCNKB SLC22A1 SLC12A7

4.55e-041251025GO:0015108
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNMB2 TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 CLCNKB PKD2 CACNA1I

5.74e-044591029GO:0005216
GeneOntologyMolecularFunctioncopper ion transmembrane transporter activity

ATP7A ATP7B

7.09e-0481022GO:0005375
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP7A ATP7B ATP4B

8.17e-04361023GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP7A ATP7B ATP4B

8.17e-04361023GO:0015662
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A6 SLC12A7

9.09e-0491022GO:0015379
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC12A6 SLC1A1 CLCNKB SLC22A1 SLC12A7

1.07e-031511025GO:0008509
GeneOntologyMolecularFunctionammonium channel activity

SLC12A6 SLC12A7

1.65e-03121022GO:0008519
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

TRPA1 PKD2 CACNA1I

1.67e-03461023GO:0005245
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC12A6 SLC1A1 CLCNKB SLC22A1 SLC12A7

1.85e-031711025GO:0015103
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNMB2 TRPA1 PIEZO1 TRPC5 TMEM175 PKD2 CACNA1I

1.90e-033431027GO:0005261
GeneOntologyMolecularFunctionG protein-coupled neurotransmitter receptor activity

GRM1 GPR158

1.94e-03131022GO:0099528
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ATP7A ATP7B ABCA13 ABCA10 ATP4B

2.21e-031781025GO:0015399
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC10A1 SLC10A2

2.60e-03151022GO:0140161
GeneOntologyMolecularFunctionpeptide hormone binding

FSHR CMKLR1 HCRTR2

2.80e-03551023GO:0017046
GeneOntologyMolecularFunctionlipid transporter activity

ABCA13 ABCA10 SLC10A1 SLC10A2 SLC22A1

3.34e-031961025GO:0005319
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TRPA1 PKD2

3.75e-03181022GO:0015278
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP7A ATP7B ATP4B

3.93e-03621023GO:0019829
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC10A1 SLC10A2

4.17e-03191022GO:0015355
GeneOntologyMolecularFunctioncalcium channel activity

TRPA1 TRPC5 PKD2 CACNA1I

4.34e-031291024GO:0005262
GeneOntologyMolecularFunctionorganic hydroxy compound transmembrane transporter activity

SLC10A1 SLC10A2 SLC22A1

5.53e-03701023GO:1901618
GeneOntologyMolecularFunctionprotein-hormone receptor activity

FSHR CMKLR1

5.58e-03221022GO:0016500
GeneOntologyMolecularFunctionC-C chemokine receptor activity

CXCR6 CCR4

6.10e-03231022GO:0016493
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC1A1 SLC6A9

6.10e-03231022GO:0005283
GeneOntologyMolecularFunctionlipid transmembrane transporter activity

SLC10A1 SLC10A2 SLC22A1

6.21e-03731023GO:0170055
GeneOntologyMolecularFunctionC-C chemokine binding

CXCR6 CCR4

6.63e-03241022GO:0019957
GeneOntologyMolecularFunctiongated channel activity

KCNMB2 TRPA1 PIEZO1 CLCNKB PKD2 CACNA1I

7.36e-033341026GO:0022836
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPA1 TRPC5 PKD2 CACNA1I

7.53e-031511024GO:0015085
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

PKD2 CACNA1I

7.75e-03261022GO:0005248
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC1A1 SLC6A9 SLC22A1

8.85e-03831023GO:0015101
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC1A1 SLC6A9

9.59e-03291022GO:0005416
GeneOntologyBiologicalProcessdetection of chemical stimulus

KCNMB2 OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 TRPA1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 OR4A16 TAS1R2 OR1E2 OR5L2 OR51V1

3.83e-2552410231GO:0009593
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 OR2M2 OR4C11 OR5G3 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 GRM1 SLC1A1 OR2L13 OR8B8 OR10D3 GPR180 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 CXCR6 GPR158 OR4A16 FSHR TAS1R2 OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

5.82e-25139510244GO:0007186
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 TRPA1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 OR4A16 TAS1R2 OR1E2 OR5L2 OR51V1

7.03e-2548510230GO:0050907
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 TRPA1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 SYT10 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 OR4A16 TAS1R2 OR1E2 OR5L2 OR51V1

1.39e-2454710231GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus

KCNMB2 OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 TRPA1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 PIEZO1 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 OR4A16 PKD2 TAS1R2 OR1E2 OR5L2 OR51V1

2.05e-2472210234GO:0051606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 TRPA1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 OR4A16 TAS1R2 OR1E2 OR5L2 OR51V1

8.92e-2458210231GO:0050906
GeneOntologyBiologicalProcesssensory perception of smell

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 SYT10 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

7.02e-2346510228GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

1.75e-2243210227GO:0050911
GeneOntologyBiologicalProcesssensory perception

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 TRPA1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 GRM1 SYT10 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 OR4A16 TAS1R2 OR1E2 OR5L2 OR51V1

5.27e-18107210233GO:0007600
GeneOntologyBiologicalProcessmonoatomic cation transport

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB SLC22A1 PKD2 CACNA1I PLPP4 TMCO3 SLC12A7 ATP4B

1.86e-07115710221GO:0006812
GeneOntologyBiologicalProcessmetal ion transport

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB PKD2 CACNA1I PLPP4 TMCO3 SLC12A7 ATP4B

3.93e-07100010219GO:0030001
GeneOntologyBiologicalProcessmonoatomic ion transport

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 PIEZO1 TRPC5 TMEM175 NMUR1 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB SLC22A1 PKD2 CACNA1I PLPP4 TMCO3 SLC12A7 ATP4B

7.67e-07137410222GO:0006811
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 SLC22A1 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

3.50e-0694210217GO:0098655
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 PIEZO1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 CLCNKB SLC22A1 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

8.19e-06111510218GO:0034220
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 GRM1 SLC1A1 TTC7A SV2B PKD2 SLC12A7 ATP4B HCRTR2

9.64e-0670510214GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 GRM1 SLC1A1 TTC7A SV2B PKD2 SLC12A7 ATP4B HCRTR2

1.16e-0571710214GO:0050801
GeneOntologyBiologicalProcessinorganic ion homeostasis

SLC12A6 ATP7A ATP7B TRPA1 TRPC5 GRM1 SLC1A1 TTC7A SV2B PKD2 SLC12A7 ATP4B HCRTR2

1.20e-0562210213GO:0098771
GeneOntologyBiologicalProcessintracellular chemical homeostasis

SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 GRM1 SLC1A1 TTC7A SV2B FSHR PKD2 SLC12A7 ATP4B HCRTR2

2.27e-0586610215GO:0055082
GeneOntologyBiologicalProcesscellular homeostasis

SLC12A6 ATP7A ATP7B TRPA1 TRPC5 MINK1 TMEM175 GRM1 SLC1A1 TTC7A SV2B FSHR PKD2 SLC12A7 ATP4B HCRTR2

2.46e-0598110216GO:0019725
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 CLCNKB PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

3.79e-05101710216GO:0098660
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

KCNMB2 SLC12A6 ATP7A ATP7B TRPA1 TRPC5 TMEM175 SLC1A1 SLC5A4 SLC6A9 PKD2 CACNA1I TMCO3 SLC12A7 ATP4B

4.66e-0592210215GO:0098662
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

ATP7A ATP7B TRPA1 TRPC5 TMEM175 GRM1 SLC1A1 TTC7A SV2B PKD2 ATP4B HCRTR2

4.88e-0561110212GO:0030003
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

ATP7A ATP7B TRPA1 TRPC5 TMEM175 GRM1 SLC1A1 TTC7A SV2B PKD2 ATP4B HCRTR2

5.79e-0562210212GO:0006873
GeneOntologyBiologicalProcesssodium ion transport

SLC5A4 SLC6A9 SLC10A1 SLC10A2 CLCNKB PKD2 CACNA1I ATP4B

6.70e-052751028GO:0006814
GeneOntologyBiologicalProcesscopper ion export

ATP7A ATP7B

7.24e-0531022GO:0060003
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A6 SLC12A7

1.44e-0441022GO:0140157
GeneOntologyBiologicalProcessimport across plasma membrane

SLC12A6 GRM1 SLC1A1 SLC6A9 CACNA1I SLC12A7 ATP4B

1.47e-042301027GO:0098739
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

KCNMB2 SLC12A6 TMEM175 PKD2 TMCO3 SLC12A7 ATP4B

1.55e-042321027GO:0071805
GeneOntologyBiologicalProcessmonoatomic anion transport

SLC12A6 TRPA1 NMUR1 SLC1A1 CLCNKB SLC12A7

2.99e-041831026GO:0006820
GeneOntologyBiologicalProcessneurotransmitter transport

SLC1A1 SYT10 SLC6A9 GPR158 SV2B SLC22A1 SV2C

3.04e-042591027GO:0006836
GeneOntologyBiologicalProcesscalcium-mediated signaling

TRPA1 NMUR1 GRM1 CXCR6 PKD2 CCR4 CMKLR1

3.57e-042661027GO:0019722
GeneOntologyBiologicalProcesschemical homeostasis

SLC12A6 ATP7A GPR21 ATP7B TRPA1 TRPC5 TMEM175 GRM1 SLC1A1 TTC7A SV2B FSHR PKD2 SLC12A7 ATP4B HCRTR2

4.05e-04124910216GO:0048878
GeneOntologyBiologicalProcesspotassium ion transport

KCNMB2 SLC12A6 TMEM175 PKD2 TMCO3 SLC12A7 ATP4B

4.08e-042721027GO:0006813
GeneOntologyBiologicalProcesschloride transport

SLC12A6 NMUR1 SLC1A1 CLCNKB SLC12A7

4.38e-041281025GO:0006821
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled receptor signaling pathway

NMUR1 GRM1 FSHR CMKLR1 HCRTR2

5.22e-041331025GO:0007200
GeneOntologyBiologicalProcessneuron cellular homeostasis

ATP7A MINK1 TMEM175 SV2B

8.03e-04841024GO:0070050
GeneOntologyBiologicalProcessregulation of cytosolic calcium ion concentration

TRPC5 GRM1 SV2B HCRTR2

8.03e-04841024GO:0051480
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A6 SLC12A7 ATP4B

8.07e-04371023GO:0055075
GeneOntologyBiologicalProcesscopper ion import

ATP7A ATP7B

8.52e-0491022GO:0015677
GeneOntologyBiologicalProcessthermoception

OPN4 TRPA1

8.52e-0491022GO:0050955
GeneOntologyBiologicalProcesscopper ion transmembrane transport

ATP7A ATP7B

8.52e-0491022GO:0035434
GeneOntologyBiologicalProcesspositive regulation of cytosolic calcium ion concentration

TRPC5 CXCR6 PKD2 CACNA1I CCR4 CMKLR1

8.68e-042241026GO:0007204
MousePhenoabnormal kidney copper level

ATP7A ATP7B

2.40e-052692MP:0010242
MousePhenoincreased kidney copper level

ATP7A ATP7B

2.40e-052692MP:0010243
MousePhenoincreased brain copper level

ATP7A ATP7B

2.40e-052692MP:0011214
MousePhenodecreased liver copper level

ATP7A ATP7B

7.18e-053692MP:0003067
MousePhenodecreased circulating copper level

ATP7A ATP7B

7.18e-053692MP:0006349
MousePhenoincreased copper level

ATP7A ATP7B

1.43e-044692MP:0014539
MousePhenoabnormal circulating copper level

ATP7A ATP7B

1.43e-044692MP:0006348
MousePhenodecreased copper level

ATP7A ATP7B

2.38e-045692MP:0014540
MousePhenoabnormal brain copper level

ATP7A ATP7B

2.38e-045692MP:0011213
DomainGPCR_Rhodpsn_7TM

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 OR2M2 OR4C11 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR2M4 OR2W3 OR51E1 OR13D1 CXCR6 OR4A16 FSHR OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

8.52e-2767010036IPR017452
Domain7tm_1

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 OR2M2 OR4C11 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR2M4 OR2W3 OR51E1 OR13D1 CXCR6 OR4A16 FSHR OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

1.22e-2667710036PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 OR2M2 OR4C11 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR2M4 OR2W3 OR51E1 OR13D1 CXCR6 OR4A16 FSHR OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

1.83e-2668510036PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 OR2M2 OR4C11 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR2M4 OR2W3 OR51E1 OR13D1 CXCR6 OR4A16 FSHR OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

2.48e-2669110036PS50262
DomainGPCR_Rhodpsn

OR5P3 OR5D16 OR2T29 OPN4 OR2M7 OR9G1 GPR21 OR2M2 OR4C11 GPR34 OR4N4 OR5B2 OR13C8 GPR82 OR5K4 NMUR1 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR2M4 OR2W3 OR51E1 OR13D1 CXCR6 OR4A16 FSHR OR1E2 CCR4 TAAR1 CMKLR1 OR5L2 OR51V1 HCRTR2

2.61e-2669210036IPR000276
DomainOlfact_rcpt

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR2M4 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

3.21e-2039310025IPR000725
Domain7TM_GPCR_Srsx

OPN4 OR2M2 NMUR1 OR2M3 OR2M4 CCR4 TAAR1 HCRTR2

1.53e-071121008SM01381
DomainHMA_Cu_ion-bd

ATP7A ATP7B

2.84e-0521002IPR006122
DomainP-typ_ATPase_IB

ATP7A ATP7B

2.84e-0521002IPR027256
DomainSV2

SV2B SV2C

8.48e-0531002IPR022308
DomainPentapeptide_4

SV2B SV2C

8.48e-0531002PF13599
DomainHeavy-metal-associated_CS

ATP7A ATP7B

8.48e-0531002IPR017969
DomainBilac:Na_transpt

SLC10A1 SLC10A2

1.69e-0441002IPR004710
Domain5peptide_repeat

SV2B SV2C

1.69e-0441002IPR001646
DomainHMA

ATP7A ATP7B

1.69e-0441002PF00403
DomainKCL_cotranspt

SLC12A6 SLC12A7

1.69e-0441002IPR000076
DomainHMA_2

ATP7A ATP7B

1.69e-0441002PS50846
DomainHMA_1

ATP7A ATP7B

1.69e-0441002PS01047
DomainGPCR_3

GRM1 GPR158 TAS1R2

1.85e-04211003IPR000337
Domain7tm_3

GRM1 GPR158 TAS1R2

2.13e-04221003PF00003
DomainG_PROTEIN_RECEP_F3_2

GRM1 GPR158 TAS1R2

2.13e-04221003PS00980
DomainG_PROTEIN_RECEP_F3_3

GRM1 GPR158 TAS1R2

2.13e-04221003PS00981
DomainG_PROTEIN_RECEP_F3_1

GRM1 GPR158 TAS1R2

2.13e-04221003PS00979
DomainG_PROTEIN_RECEP_F3_4

GRM1 GPR158 TAS1R2

2.13e-04221003PS50259
DomainGPCR_3_C

GRM1 GPR158 TAS1R2

2.13e-04221003IPR017978
DomainSLC12A_fam

SLC12A6 SLC12A7

5.86e-0471002IPR004842
DomainBilAc:Na_symport/Acr3

SLC10A1 SLC10A2

5.86e-0471002IPR002657
DomainSBF

SLC10A1 SLC10A2

5.86e-0471002PF01758
DomainHMA_dom

ATP7A ATP7B

5.86e-0471002IPR006121
DomainSugar_transporter_CS

SV2B SLC22A1 SV2C

6.60e-04321003IPR005829
DomainSLC12_C

SLC12A6 SLC12A7

7.78e-0481002IPR018491
DomainSLC12

SLC12A6 SLC12A7

7.78e-0481002PF03522
DomainMFS_sugar_transport-like

SV2B SLC22A1 SV2C

9.35e-04361003IPR005828
DomainSugar_tr

SV2B SLC22A1 SV2C

9.35e-04361003PF00083
DomainABC_A

ABCA13 ABCA10

1.81e-03121002IPR026082
DomainNCD3G

GRM1 TAS1R2

2.13e-03131002PF07562
DomainGPCR_3_9-Cys_dom

GRM1 TAS1R2

2.13e-03131002IPR011500
DomainGPCR_3_CS

GRM1 TAS1R2

2.48e-03141002IPR017979
DomainChemokine_rcpt

CXCR6 CCR4

3.24e-03161002IPR000355
DomainCa/CaM-dep_Ca-dep_prot_Kinase

TSSK2 TSSK3 TSSK1B

6.04e-03691003IPR020636
DomainAA-permease/SLC12A_dom

SLC12A6 SLC12A7

6.11e-03221002IPR004841
DomainAA_permease

SLC12A6 SLC12A7

6.11e-03221002PF00324
DomainTHIOREDOXIN_1

TMX2 DNAJC10

7.86e-03251002PS00194
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

1.45e-204178827M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR5K4 OR1C1 OR2T5 OR2M5 OR2M3 GRM1 OR2L13 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 TAS2R14 OR13D1 OR4A16 TAS1R2 OR1E2 OR5L2 OR51V1

5.52e-196368830M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR4N4 OR13C8 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR2M4 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

1.22e-163898823M14091
PathwayWP_GPCRS_ODORANT

OR5P3 GPR21 GPR34 GPR82 OR8B8 OR10D3 GPR180 TAS2R14 GPR158 TAS1R2 OR1E2 CMKLR1

2.36e-101578812MM15872
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5P3 OR2T29 OR9G1 OR2T5 OR2L13 OR2W3 OR51E1 OR1E2

1.15e-0870888MM14984
PathwayREACTOME_SENSORY_PERCEPTION

OR5P3 OR2T29 OR9G1 OR2T5 OR2L13 OR2W3 OR51E1 TAS2R14 TAS1R2 OR1E2

2.83e-071908810MM15687
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OPN4 GPR21 GPR34 NMUR1 OR1C1 OR8B8 FSHR OR1E2 CCR4 CMKLR1 HCRTR2

6.21e-072608811M39397
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR5P3 OPN4 GPR34 NMUR1 OR8B8 FSHR CCR4 CMKLR1

2.06e-05186888MM15994
PathwayWP_GPCRS_NONODORANT

OPN4 NMUR1 GRM1 TAS2R14 CXCR6 FSHR CCR4 TAAR1 HCRTR2

4.12e-05266889MM15843
PathwayREACTOME_GPCR_LIGAND_BINDING

OPN4 NMUR1 GRM1 TAS2R14 CXCR6 FSHR TAS1R2 CCR4 TAAR1 CMKLR1 HCRTR2

7.24e-054308811MM15160
PathwayREACTOME_GPCR_LIGAND_BINDING

OPN4 NMUR1 GRM1 TAS2R14 CXCR6 FSHR TAS1R2 CCR4 TAAR1 CMKLR1 HCRTR2

1.39e-044638811M507
PathwayREACTOME_TOXICITY_OF_BOTULINUM_TOXIN_TYPE_D_BOTD

SV2B SV2C

3.81e-045882M27427
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC12A6 ATP7A ATP7B TRPA1 TRPC5 SLC1A1 ABCA10 SLC5A4 SLC6A9 CLCNKB SLC22A1 SLC12A7 ATP4B

6.16e-047368813M27287
PathwayREACTOME_SIGNALING_BY_GPCR

OPN4 NMUR1 GRM1 TAS2R14 CXCR6 FSHR TAS1R2 CCR4 TAAR1 CMKLR1 HCRTR2 FGD3

6.53e-046468812MM14962
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A7

7.93e-047882M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A7

7.93e-047882MM15081
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP7A ATP7B TRPA1 TRPC5 CLCNKB ATP4B

8.09e-04176886MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP7A ATP7B TRPA1 TRPC5 CLCNKB ATP4B

9.90e-04183886M997
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC12A6 ATP7A ATP7B TRPA1 TRPC5 SLC1A1 SLC5A4 SLC6A9 CLCNKB SLC22A1 SLC12A7 ATP4B

1.04e-036818812MM14985
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

OPN4 NMUR1 CXCR6 FSHR CCR4 TAAR1 CMKLR1 HCRTR2

1.05e-03330888M18334
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

OPN4 NMUR1 CXCR6 FSHR CCR4 TAAR1 CMKLR1 HCRTR2

1.11e-03333888MM14963
PathwayWP_PEPTIDE_GPCRS

CXCR6 FSHR CCR4 HCRTR2

1.23e-0375884M39696
PathwayREACTOME_SIGNALING_BY_GPCR

OPN4 NMUR1 GRM1 TAS2R14 CXCR6 FSHR TAS1R2 CCR4 TAAR1 CMKLR1 HCRTR2 FGD3

1.34e-037028812M746
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

GRM1 TAS2R14 TAS1R2

1.57e-0337883MM15067
PathwayREACTOME_NEUROTOXICITY_OF_CLOSTRIDIUM_TOXINS

SV2B SV2C

1.68e-0310882M27018
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

GRM1 TAS2R14 TAS1R2

1.83e-0339883M793
PathwayWP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION

SLC10A1 SLC10A2

2.44e-0312882M39802
PathwayWP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS

SLC10A1 SLC10A2

2.44e-0312882M48096
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

GRM1 TAS2R14 TAS1R2

3.13e-0347883M42524
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR5B2 OR13C8 OR5K4 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

1.76e-263401022411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR5B2 OR13C8 OR5K4 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

1.76e-263401022411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR5B2 OR13C8 OR5K4 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

2.17e-263431022432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5P3 OR5D16 OR2T29 OR2M7 OR9G1 OR2M2 OR4C11 OR5G3 OR5B2 OR13C8 OR5K4 OR2T5 OR2M5 OR2M3 OR2L13 OR8B8 OR10D3 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

2.68e-263461022414611657
Pubmed

The human olfactory receptor gene family.

OR5P3 OR5D16 OR2M7 OR9G1 OR4C11 OR5G3 OR4N4 OR5B2 OR13C8 OR1C1 OR2T5 OR2M5 OR2M3 OR8B8 OR10D3 OR2M4 OR2W3 OR51E1 OR13D1 OR4A16 OR1E2 OR5L2 OR51V1

2.17e-205411022314983052
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR5P3 OR5D16 OR2M2 OR5B2 OR13C8 OR1C1 OR2M3 OR8B8 OR2M4 OR2W3 OR1E2 OR5L2

2.36e-122191021212213199
Pubmed

High-throughput microarray detection of olfactory receptor gene expression in the mouse.

OR2M7 OR2M2 OR2M5 OR2M3

6.97e-114102415377787
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR2T29 OR4C11 OR2T5 OR2W3 OR4A16 OR1E2

8.64e-0874102615081110
Pubmed

A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice.

TSSK2 TSSK3 TSSK1B

9.78e-084102310781952
Pubmed

Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.

TSSK2 TSSK3 TSSK1B

4.87e-076102320729278
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR1C1 OR8B8 OR2M4 OR1E2

7.08e-072410249119360
Pubmed

[From gene to disease: copper-transporting P ATPases alteration].

ATP7A ATP7B

8.52e-062102219046832
Pubmed

Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy.

ATP7A ATP7B

8.52e-062102229394468
Pubmed

Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels.

ATP7A ATP7B

8.52e-06210228082762
Pubmed

Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations.

SLC10A1 SLC10A2

8.52e-062102221341987
Pubmed

Solution structures of the actuator domain of ATP7A and ATP7B, the Menkes and Wilson disease proteins.

ATP7A ATP7B

8.52e-062102219645496
Pubmed

Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta.

ATP7A ATP7B

8.52e-062102221115196
Pubmed

Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b.

ATP7A ATP7B

8.52e-062102212372948
Pubmed

Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells.

ATP7A ATP7B

8.52e-062102218565219
Pubmed

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells.

PIEZO1 PKD2

8.52e-062102224157948
Pubmed

Copper transporting P-type ATPases and human disease.

ATP7A ATP7B

8.52e-062102212539960
Pubmed

Mechanisms of charge transfer in human copper ATPases ATP7A and ATP7B.

ATP7A ATP7B

8.52e-062102228164426
Pubmed

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.

ATP7A ATP7B

8.52e-062102217109627
Pubmed

Quantitative relationship between mutated amino-acid sequence of human copper-transporting ATPases and their related diseases.

ATP7A ATP7B

8.52e-062102218688737
Pubmed

Biochemical basis of regulation of human copper-transporting ATPases.

ATP7A ATP7B

8.52e-062102217562324
Pubmed

Genes regulating copper metabolism.

ATP7A ATP7B

8.52e-06210229823011
Pubmed

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.

SLC12A6 SLC12A7

8.52e-062102231393094
Pubmed

Expression and localization of menkes and Wilson copper transporting ATPases in human placenta.

ATP7A ATP7B

8.52e-062102215135234
Pubmed

Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes.

ATP7A ATP7B

8.52e-062102217717039
Pubmed

Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters.

ATP7A ATP7B

8.52e-06210229215673
Pubmed

Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.

ATP7A ATP7B

8.52e-062102220045993
Pubmed

Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins.

ATP7A ATP7B

8.52e-062102218000748
Pubmed

Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B.

ATP7A ATP7B

8.52e-062102238032054
Pubmed

Molecular features of copper binding proteins involved in copper homeostasis.

ATP7A ATP7B

8.52e-062102227896900
Pubmed

Menkes disease: recent advances and new insights into copper metabolism.

ATP7A ATP7B

8.52e-06210228732640
Pubmed

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.

SLC12A6 SLC12A7

8.52e-062102210347194
Pubmed

Effects of Ala substitution for conserved Cys residues in mouse ileal and hepatic Na+-dependent bile acid transporters.

SLC10A1 SLC10A2

8.52e-062102217690477
Pubmed

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.

ATP7A ATP7B

8.52e-062102217531189
Pubmed

Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.

ATP7A ATP7B

8.52e-062102217928409
Pubmed

Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.

ATP7A ATP7B

8.52e-062102228271598
Pubmed

The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.

SLC10A1 SLC22A1

8.52e-062102217635184
Pubmed

[Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases].

ATP7A ATP7B

8.52e-062102221117320
Pubmed

Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb.

OR8B8 SV2B SV2C

1.33e-0516102317715346
Pubmed

Dissociation of heterotrimeric g proteins in cells.

OPN4 NMUR1 CXCR6 FSHR CCR4 TAAR1

1.53e-05179102618577758
Pubmed

Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.

TSSK2 TSSK1B

2.55e-053102223258646
Pubmed

Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.

SV2B SV2C

2.55e-053102223617838
Pubmed

Separation of function for classical and ganglion cell photoreceptors with respect to circadian rhythm entrainment and induction of photosomnolence.

OPN4 HPS4

2.55e-053102221985934
Pubmed

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases.

ATP7A ATP7B

2.55e-053102216884690
Pubmed

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.

SLC12A6 SLC12A7

2.55e-053102217133354
Pubmed

Intestinal expression of metal transporters in Wilson's disease.

ATP7A ATP7B

2.55e-053102223963605
Pubmed

[Cloning and expression of Tssk1 & Tssk2 in mice and the presence & localization of them in mature sperm].

TSSK2 TSSK1B

2.55e-053102222855445
Pubmed

Immunohistochemical analysis of the expression of two serine-threonine kinases in the maturing mouse testis.

TSSK2 TSSK1B

2.55e-05310229651519
Pubmed

Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.

ATP7A ATP7B

2.55e-053102221242307
Pubmed

Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.

ATP7A ATP7B

2.55e-053102228737129
Pubmed

No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.

SV2B SV2C

2.55e-053102218977120
Pubmed

ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase.

ATP7A ATP7B

2.55e-053102230341172
Pubmed

Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.

ATP7A ATP7B

2.55e-053102223751120
Pubmed

The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum.

ATP7A ATP7B

2.55e-053102215634671
Pubmed

SV2 is the protein receptor for botulinum neurotoxin A.

SV2B SV2C

2.55e-053102216543415
Pubmed

Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis.

ATP7A ATP7B

2.55e-053102210557326
Pubmed

Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina.

SV2B SV2C

2.55e-053102212687700
Pubmed

Expression of SV2 isoforms during rodent brain development.

SV2B SV2C

2.55e-053102223937191
Pubmed

SV2 modulates the size of the readily releasable pool of secretory vesicles.

SV2B SV2C

2.55e-053102211483953
Pubmed

Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

SLC12A6 SLC12A7

2.55e-053102224089410
Pubmed

Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns.

SV2B SV2C

2.55e-053102233588752
Pubmed

Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.

ATP7A ATP7B

2.55e-053102220566629
Pubmed

Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p.

ATP7A ATP7B

2.55e-053102210497213
Pubmed

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

SLC12A6 SLC12A7

2.55e-053102211551954
Pubmed

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.

SLC12A6 SLC12A7

2.55e-053102215262997
Pubmed

Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.

SLC12A6 SLC12A7

2.55e-053102212657561
Pubmed

K-Cl cotransporter gene expression during human and murine erythroid differentiation.

SLC12A6 SLC12A7

2.55e-053102221733850
Pubmed

Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse.

TSSK2 CDC45 TSSK1B

2.69e-052010239740669
Pubmed

Use of (alternative) coreceptors for HIV entry.

CXCR6 CCR4 CMKLR1

3.13e-0521102322842622
Pubmed

Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.

TTC7A FSHR CMKLR1

4.16e-0523102320932654
Pubmed

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.

ATP7A ATP7B

5.09e-054102222130675
Pubmed

Discovery of three novel orphan G-protein-coupled receptors.

GPR34 CCR4

5.09e-054102210036181
Pubmed

Odontoblast TRPC5 channels signal cold pain in teeth.

TRPA1 TRPC5

5.09e-054102233771873
Pubmed

Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.

GRM1 SLC1A1

5.09e-054102215140926
Pubmed

Genomic organization of the mottled gene, the mouse homologue of the human Menkes disease gene.

ATP7A ATP7B

5.09e-05410228921375
Pubmed

Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells.

ATP7A ATP7B

5.09e-054102227112899
Pubmed

TSKS concentrates in spermatid centrioles during flagellogenesis.

TSSK2 TSSK1B

5.09e-054102218495105
Pubmed

Keratinocytes contribute to normal cold and heat sensation.

TRPA1 TRPC5

5.09e-054102232729832
Pubmed

The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis.

SLC10A1 SLC10A2

5.09e-054102223125159
Pubmed

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

SLC12A6 SLC12A7

5.09e-054102212637262
Pubmed

A novel family of serine/threonine kinases participating in spermiogenesis.

TSSK2 TSSK1B

5.09e-05410229412477
Pubmed

Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.

TSSK2 TSSK1B

5.09e-054102218533145
Pubmed

Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.

TSSK2 TSSK1B

5.09e-054102220053632
Pubmed

Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

OR10D3 OR2M4 OR5L2

5.37e-052510231370859
Pubmed

Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.

XDH EPG5 GPR158

6.81e-0527102318649358
Pubmed

An introduction to TRP channels.

TRPA1 TRPC5 PKD2

6.81e-0527102316460286
Pubmed

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.

TSSK2 CDC45 TSSK1B

7.61e-0528102310963672
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP7A ATP7B ATP4B

8.47e-0529102315071553
Pubmed

Atp7a and Atp7b regulate copper homeostasis in developing male germ cells in mice.

ATP7A ATP7B

8.47e-055102228820536
Pubmed

Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.

TSSK2 TSSK1B

8.47e-055102215044604
Pubmed

Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.

TSSK2 CDC45 TSSK1B

1.25e-0433102310704284
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPA1 TRPC5 PKD2

1.25e-0433102319834762
Pubmed

Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility.

TSSK2 TSSK1B

1.27e-046102223599433
Pubmed

SV2B regulates synaptotagmin 1 by direct interaction.

SV2B SV2C

1.27e-046102215466855
Pubmed

Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice.

SV2B SV2C

1.27e-046102216614351
Pubmed

The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships.

SLC10A1 SLC10A2

1.27e-046102216541252
InteractionFADS1 interactions

OR2M7 GPR21 SLC5A4 CMKLR1 TMCO3 HCRTR2

2.37e-0687896int:FADS1
InteractionOR10H1 interactions

SLC12A6 ATP7A PIEZO1 PKD2 SLC12A7

2.45e-0649895int:OR10H1
InteractionFAM229B interactions

TSSK2 TSSK1B

5.77e-053892int:FAM229B
InteractionC3orf52 interactions

SLC12A6 DNAJC13 PIEZO1 TMX2 SLC10A1 SLC10A2 PKD2 SLC12A7

6.13e-05305898int:C3orf52
Cytoband1q44

OR2T29 OR2M7 OR2M2 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR2M4 OR2W3

7.27e-14110102101q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T29 OR2M7 OR2M2 OR1C1 OR2T5 OR2M5 OR2M3 OR2L13 OR2M4 OR2W3

3.40e-1312810210chr1q44
Cytoband11q11

OR5D16 OR4C11 OR4A16 OR5L2

3.81e-0647102411q11
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5D16 OR9G1 OR5G3 OR5B2 TMX2 OR5L2

1.27e-043451026chr11q12
GeneFamilyOlfactory receptors, family 2

OR2T29 OR2M7 OR2M2 OR2T5 OR2M5 OR2M3 OR2L13 OR2M4 OR2W3

2.11e-09113829149
GeneFamilyOlfactory receptors, family 5

OR5P3 OR5D16 OR5G3 OR5B2 OR5K4 OR5L2

1.18e-05112826152
GeneFamilyATPase copper transporting

ATP7A ATP7B

2.03e-0528221212
GeneFamilyTransient receptor potential cation channels

TRPA1 TRPC5 PKD2

2.71e-0428823249
GeneFamilySolute carriers

SLC12A6 SLC1A1 SLC5A4 SLC6A9 SLC10A1 SLC10A2 SLC22A1 SLC12A7

4.21e-04395828752
GeneFamilyATP binding cassette subfamily A

ABCA13 ABCA10

1.78e-0314822805
GeneFamilyProtein disulfide isomerases

TMX2 DNAJC10

4.03e-0321822692
GeneFamilyOlfactory receptors, family 13

OR13C8 OR13D1

4.83e-0323822162
GeneFamilyG protein-coupled receptors, Class A orphans

GPR21 GPR34 GPR82

5.36e-0378823262
GeneFamilyOlfactory receptors, family 1

OR1C1 OR1E2

1.42e-0240822147
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADAM19 CXCR6 LEPROTL1 CACNA1I CCR4 FGD3

1.17e-061491016f4bee5fdaaa4a1917e403de90e5a62353006df24
Diseaseoccipital horn syndrome (implicated_via_orthology)

ATP7A ATP7B

9.62e-062922DOID:0111272 (implicated_via_orthology)
Diseasemetal metabolism disorder (implicated_via_orthology)

ATP7A ATP7B

5.75e-054922DOID:896 (implicated_via_orthology)
DiseaseWilson disease (implicated_via_orthology)

ATP7A ATP7B

9.56e-055922DOID:893 (implicated_via_orthology)
DiseaseMenkes disease (implicated_via_orthology)

ATP7A ATP7B

9.56e-055922DOID:1838 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SLC12A6 MINK1 SLC1A1 SLC12A7 ATP4B

1.61e-04163925DOID:1826 (implicated_via_orthology)
Diseaseresponse to radiation, prostate carcinoma, erectile dysfunction

TTC7A FSHR CMKLR1

2.11e-0437923EFO_0001663, EFO_0004234, GO_0009314
Diseasespinal muscular atrophy (implicated_via_orthology)

ATP7A ATP7B

3.41e-049922DOID:12377 (implicated_via_orthology)
Diseaseinterleukin 17 measurement

GRM1 SLC1A1 TTC7A

3.79e-0445923EFO_0008174
Diseaserenal fibrosis (implicated_via_orthology)

GPR21 XDH

1.27e-0317922DOID:0050855 (implicated_via_orthology)
Diseaseresponse to methotrexate, juvenile idiopathic arthritis

CACNA1I CMKLR1

1.59e-0319922EFO_0002609, GO_0031427
DiseaseX-24309 measurement

ACP6 DNAJC13

1.76e-0320922EFO_0800872
Diseaseprogression free survival, ovarian serous carcinoma

ABCA13 SLC1A1

2.13e-0322922EFO_0004920, EFO_1001516
DiseaseEpilepsy, Benign Psychomotor, Childhood

GRM1 SLC1A1

2.33e-0323922C0393672
DiseaseEpilepsy, Lateral Temporal

GRM1 SLC1A1

2.33e-0323922C0393682
DiseaseUncinate Epilepsy

GRM1 SLC1A1

2.33e-0323922C0014558
DiseaseEpilepsy, Temporal Lobe

GRM1 SLC1A1

2.33e-0323922C0014556
Diseasecoffee consumption measurement

OR2M2 OR2M3 TAS2R14 PKD2

2.56e-03182924EFO_0006781
Diseasepseudotumor cerebri

OR9G1 TAS2R14

2.98e-0326922EFO_1001132

Protein segments in the cluster

PeptideGeneStartEntry
GMPIGCYLALSMTAV

EPG5

1016

Q9HCE0
MTLGFFLPLLTMIVC

CXCR6

196

O00574
CMIFIPSFTLLGYVM

ABCA10

1076

Q8WWZ4
IGLAPLMAMCSVYQS

ADAM19

311

Q9H013
CSLVFGIPVMALMIY

ATP7B

656

P35670
CLDPVMYFLMSSNIR

GPR34

321

Q9UPC5
FIFGLCTMLITIMPR

ABCA13

4576

Q86UQ4
MCLMYGATLILASPI

ACSF2

321

Q96CM8
LVIPLGIMLFCYSMI

CCR4

211

P51679
GIMLFCYSMIIRTLQ

CCR4

216

P51679
PLYSRQMMSELLFEC

ACTR5

141

Q9H9F9
SRPMQMALYFCSGLL

DIS3L2

666

Q8IYB7
MTGLFALCLYVLMQT

ATP4B

51

P51164
VSLFFCIPVMGLMIY

ATP7A

656

Q04656
LYMVTMSPQVCFLLL

OR8B8

131

Q15620
IMMYFLLASNVICPA

OR9G1

196

Q8NH87
VDFCYSSIIAPMMLV

OR5D16

71

Q8NGK9
VCSIMMYFLLGITLL

KCNMB2

56

Q9Y691
NLLVCSAMPFMSIYF

GPR82

61

Q96P67
CLPMAIMSVLYLLIG

NMUR1

241

Q9HB89
MGAMAYPLLLCLLLA

GPR158

1

Q5T848
PAESCMGLVRMNLYT

HPS4

531

Q9NQG7
LMLICTTVPKMAFNY

OR2M2

71

Q96R28
YSTAMSPKLMIDLLC

OR4A16

71

Q8NH70
LMLICTTVPKMAFNY

OR2M3

71

Q8NG83
RYTNLMSPKICGLMT

OR2M3

131

Q8NG83
LMLICTTLPKMIFSY

OR2M4

71

Q96R27
LMLICSTVPKMAFNY

OR2M5

71

A3KFT3
LMLICTTVPKMAFNY

OR2M7

71

Q8NG81
VSAPECGMQMFLYLT

OR2T5

96

Q6IEZ7
MYIFLCMLSGIDILI

OR51E1

61

Q8TCB6
GMFLMLFYNIVTPLL

OR2W3

271

Q7Z3T1
SSIYAMVLLGNCMVL

OR51V1

41

Q9H2C8
IILLMFGPAIFIYMC

OR4N4

246

Q8N0Y3
FIYLLTLCGNLGMML

OR5B2

31

Q96R09
IGLMFLMLGCALPIY

LEPROTL1

16

O95214
NSMILYCVPKLRLMG

FGD3

396

Q5JSP0
SQIQMLYLLLSLCMG

GPR180

251

Q86V85
PLLKLACMDTYMINL

OR4C11

181

Q6IEV9
AAILPLYCAMMIALS

PLPP4

181

Q5VZY2
VSAPECGMQMFLYLT

OR2T29

96

Q8NH02
STFCALGMMPLLLYI

SLC10A1

126

Q14973
MSFTPAVRAYTMLLC

OPN4

226

Q9UHM6
TYMAPLCLMVLAYLQ

HCRTR2

231

O43614
AILNRMCLVYPASKM

CKAP5

1311

Q14008
LYCSLMEGTPDVMLF

CDC45

446

O75419
MLVILLNCVTLGMYQ

CACNA1I

86

Q9P0X4
LILNMLITMCGYFPS

DNAJC13

1046

O75165
MLCRMKGVNSYPSLF

DNAJC10

191

Q8IXB1
FGISSYMKVSICLPM

FSHR

506

P23945
ALGCMFTPKMYIIIA

GRM1

826

Q13255
VMMLYAPAALIVCFT

GPR21

196

Q99679
KYTRPTLQMGMSCLL

PIWIL3

561

Q7Z3Z3
LVAPILSMFFLMCYL

SLC12A6

641

Q9UHW9
SVAPILSMFFLMCYL

SLC12A7

576

Q9Y666
SPNYMSMLLFRLLQG

SLC22A1

196

O15245
QLCEMLGRMYSTIPQ

IPO13

726

O94829
MIFLRGMLTLGCTLY

BVES

66

Q8NE79
MNCYLLLRFMLGIPL

CDH19

1

Q9H159
VQIIMCYMPLGILFL

SLC1A1

251

P43005
FLCMYLATTLGNMLI

OR1C1

31

Q15619
YTAIMSPMLCLSVVA

OR1E2

141

P47887
MGFSSVTCPKMLLYL

OR10D3

71

Q8NH80
VTCPKMLLYLMGLSR

OR10D3

76

Q8NH80
CMQLVVGPYAMALIS

OR5G3

141

P0C626
LALGMMPLCLLIYTK

SLC10A2

136

Q12908
IFLPNTDGMEMLLCY

MINK1

1216

Q8N4C8
SLFYGVMTPMLNPLI

OR13C8

281

Q8NGS7
LLCLIMYMIILLGNS

OR13D1

61

Q8NGV5
TPMYFLLSQLSLMDL

OR2L13

56

Q8N349
LIILSQVMGMAYPSC

TAS2R14

261

Q9NYV8
SMCFLSFLVPPMTIY

ERVW-1

286

Q9UQF0
MIGMLCLYNGLTISA

SV2C

636

Q496J9
SLQGPCYMTLLMIAF

TMCO3

351

Q6UWJ1
CVMGPYRMNTLILAV

SV2B

381

Q7L1I2
IVKMTMPQTLAFCYL

TAF1B

206

Q53T94
PGMISRILYTDMVAC

SLC5A4

331

Q9NY91
CRLMAPYTPFLTELM

IARS1

766

P41252
MSPGVCIILVGMSYL

OR5P3

136

Q8WZ94
LTPMYIFLGNLALMD

OR5K4

56

A6NMS3
ICNPLLYMVTMSQKL

OR5L2

126

Q8NGL0
RALMLTSQYLMEPCG

STARD8

956

Q92502
IANSCMNPILYVFMG

CMKLR1

306

Q99788
YFLMTLGVLMALVSC

CLCNKB

51

P51801
RMGLLYITLCIVFLM

TMX2

111

Q9Y320
MNLGSYCLGLIPMTI

TRPA1

721

O75762
LLNLACMMTITFLPY

TMEM175

111

Q9BSA9
MGVVLYVMLCASLPF

TSSK3

196

Q96PN8
RSQPPLLTLMMDCYL

TREH

221

O43280
MALSSVLCIPLYAMF

SLC6A9

616

P48067
CTPGIVMSMYTLLRN

XDH

116

P47989
GLCPLDMFLNAMSVY

ACP6

391

Q9NPH0
LLGCLVMPYSMVRSA

TAAR1

71

Q96RJ0
LIVLCILTYGMMSSN

PKD2

231

Q13563
EIMFSLCYLPTAGRM

SYT10

366

Q6XYQ8
GPMCFLMLTLLLVAY

TAS1R2

601

Q8TE23
SLGVILYIMVCGSMP

TSSK1B

201

Q9BXA7
SPQYMCEAMLILGKL

TTC7A

116

Q9ULT0
IYTLLGLMMNLCLQA

TTC12

496

Q9H892
LLTCMTIGFLFPMLS

TRPC5

331

Q9UL62
QLAMLCSPCILLYGM

PIEZO1

461

Q92508
MNKSPMLITGIRCLY

TRUB2

201

O95900
LLPMVILSGCAMFFS

YIPF7

211

Q8N8F6
SLGVILYIMVCGSMP

TSSK2

201

Q96PF2
MLSLSPILLYTCEMF

ZNF439

1

Q8NDP4
AFLASMIGPQALYMC

N6AMT1

61

Q9Y5N5