Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein kinase binding

DAB2IP SPDYE17 SPDYE10 PPP1R12A PPP1R12B TRIM68 SPDYE11 CDK5RAP3 SPDYE15 PTPRK SPDYE8 KIF14 PLD2 CDH1 NBR1 SPDYE14 DNM2

7.02e-0587313317GO:0019901
GeneOntologyMolecularFunctionkinase binding

DAB2IP SPDYE17 PDE8A SPDYE10 PPP1R12A PPP1R12B TRIM68 SPDYE11 CDK5RAP3 SPDYE15 PTPRK SPDYE8 KIF14 PLD2 CDH1 NBR1 SPDYE14 DNM2

7.74e-0596913318GO:0019900
GeneOntologyMolecularFunctioncalcium ion binding

FAT4 TBC1D9B PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PLCD4 PCDHA6 TBC1D9 PRRG3 CDH1 PCDHGC3 PCDH8

1.42e-0474913315GO:0005509
GeneOntologyMolecularFunctionATP hydrolysis activity

CFTR RNF213 CHD8 ATP9B FANCM DHX15 ENTPD1 KIF14 DNA2 DNAH5 DNAH8

1.81e-0444113311GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

MYO7B CFTR RNF213 CHD8 ATP9B FANCM DHX15 MOCS3 ENTPD1 KIF14 DNA2 DNAH5 DNAH8

2.36e-0461413313GO:0140657
GeneOntologyMolecularFunctionenzyme regulator activity

DAB2IP TBC1D9B PDE8A PPP1R12A PPP1R12B MCF2L2 ARFGEF2 PLCD4 APOA4 SHOC2 CARD8 TBC1D9 ITIH5 PLEKHG4B PPP2R1B THADA C3 ARHGAP27 GNAZ DOCK6 RASAL2

4.45e-04141813321GO:0030234
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

FAT4 PCDHGB3 TRO FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PLXNB2 CDH1 PCDHGC3 PCDH8

1.16e-1018712513GO:0007156
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

FAT4 PCDHGB3 TRO FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PLXNB2 ARVCF CDH1 PCDHGC3 PCDH8

6.94e-0931312514GO:0098742
GeneOntologyBiologicalProcesscalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

PCDHB13 PCDHB11 PCDHB4 ARVCF CDH1 PCDHGC3

7.98e-07531256GO:0016339
GeneOntologyBiologicalProcesscell-cell adhesion

FAT4 PCDHGB3 TRO FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 APOA4 PRDX2 PLXNB2 PLEKHG4B NLGN3 ARVCF ENTPD1 PLEKHA7 CDH1 PCDHGC3 PCDH8

7.32e-06107712520GO:0098609
GeneOntologyCellularComponentAIP1-IRE1 complex

DAB2IP ERN1

3.60e-0521262GO:1990597
DomainCA

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 FREM2 CDH1 PCDHGC3 PCDH8

1.63e-1111512512SM00112
DomainCadherin

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 FREM2 CDH1 PCDHGC3 PCDH8

2.21e-1111812512IPR002126
DomainCadherin_CS

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 CDH1 PCDHGC3 PCDH8

1.70e-1010912511IPR020894
DomainCADHERIN_1

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 CDH1 PCDHGC3 PCDH8

2.52e-1011312511PS00232
DomainCadherin

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 CDH1 PCDHGC3 PCDH8

2.52e-1011312511PF00028
DomainCADHERIN_2

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 CDH1 PCDHGC3 PCDH8

2.78e-1011412511PS50268
Domain-

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 CDH1 PCDHGC3 PCDH8

2.78e-10114125112.60.40.60
DomainCadherin-like

FAT4 PCDHGB3 FAT3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 CDH1 PCDHGC3 PCDH8

3.35e-1011612511IPR015919
DomainCadherin_2

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3 PCDH8

1.18e-08651258PF08266
DomainCadherin_N

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3 PCDH8

1.18e-08651258IPR013164
DomainCadherin_C

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHGC3

3.43e-07421256IPR032455
DomainCadherin_C_2

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHGC3

3.43e-07421256PF16492
Domain-

DAB2IP MYO7B MCF2L2 PLCD4 PLEKHG4B OSBPL7 GAB3 PLD2 ARHGAP27 PLEKHA7 TNS1 RASAL2 DNM2

2.24e-06391125132.30.29.30
DomainPH

DAB2IP MCF2L2 PLCD4 PLEKHG4B OSBPL7 GAB3 PLD2 ARHGAP27 PLEKHA7 RASAL2 DNM2

2.70e-0627812511SM00233
DomainPH_DOMAIN

DAB2IP MCF2L2 PLCD4 PLEKHG4B OSBPL7 GAB3 PLD2 ARHGAP27 PLEKHA7 RASAL2 DNM2

2.79e-0627912511PS50003
DomainPH_domain

DAB2IP MCF2L2 PLCD4 PLEKHG4B OSBPL7 GAB3 PLD2 ARHGAP27 PLEKHA7 RASAL2 DNM2

2.89e-0628012511IPR001849
DomainPH_dom-like

DAB2IP MYO7B MCF2L2 PLCD4 PLEKHG4B OSBPL7 GAB3 PLD2 ARHGAP27 PLEKHA7 TNS1 RASAL2 DNM2

5.70e-0642612513IPR011993
DomainPDEase_PDE8

PDE8A PDE8B

4.44e-0521252IPR013938
DomainDUF3498

DAB2IP RASAL2

1.33e-0431252IPR021887
DomainPRKG1_interact

PPP1R12A PPP1R12B

1.33e-0431252IPR031775
DomainPRKG1_interact

PPP1R12A PPP1R12B

1.33e-0431252PF15898
DomainMYPT1/MYPT2_chordates

PPP1R12A PPP1R12B

1.33e-0431252IPR017401
DomainDUF3498

DAB2IP RASAL2

1.33e-0431252PF12004
Domain-

DAB2IP PLXNB2 RASAL2

1.54e-041612531.10.506.10
DomainRasGAP_dom

DAB2IP PLXNB2 RASAL2

2.22e-04181253IPR001936
DomainThyrH_rcpt

THRA THRB

4.39e-0451252IPR001728
DomainARM-type_fold

ARFGEF2 FRYL ARMC9 PPP2R1B THADA ARVCF PI4KA FHOD1 FMNL1

4.65e-043391259IPR016024
DomainPUB_domain

RNF31 ERN1

6.55e-0461252IPR018997
DomainIg_E-set

ARRDC4 PLXNB2 PKHD1L1 F13A1 KCNJ5

6.72e-041041255IPR014756
DomainPH

PLCD4 OSBPL7 GAB3 PLD2 ARHGAP27 PLEKHA7 DNM2

8.91e-042291257PF00169
DomainDHC_N1

DNAH5 DNAH8

1.21e-0381252PF08385
DomainDynein_heavy_dom-1

DNAH5 DNAH8

1.21e-0381252IPR013594
Domain-

MYO7B CFTR RNF213 CHD8 FANCM TEP1 DHX15 GNAZ DNA2 HS3ST1 DNAH5 DNAH8 DNM2

1.48e-03746125133.40.50.300
DomainP-loop_NTPase

MYO7B CFTR RNF213 CHD8 FANCM TEP1 DHX15 KIF14 GNAZ DNA2 HS3ST1 DNAH5 DNAH8 DNM2

1.62e-0384812514IPR027417
DomainDNA/RNA_helicase_DEAH_CS

CHD8 FANCM DHX15

1.64e-03351253IPR002464
DomainCadherin_tail

PCDHGB3 PCDHA6 PCDHGC3

1.93e-03371253PF15974
DomainCadherin_CBD

PCDHGB3 PCDHA6 PCDHGC3

1.93e-03371253IPR031904
DomainDEAH_ATP_HELICASE

CHD8 FANCM DHX15

2.08e-03381253PS00690
DomainGBD/FH3_dom

FHOD1 FMNL1

2.35e-03111252IPR014768
DomainGBD_FH3

FHOD1 FMNL1

2.35e-03111252PS51232
DomainAAA

CFTR RNF213 DHX15 DNAH5 DNAH8

2.84e-031441255SM00382
DomainAAA+_ATPase

CFTR RNF213 DHX15 DNAH5 DNAH8

2.84e-031441255IPR003593
DomainRho_GTPase_activation_prot

DAB2IP PLXNB2 ARHGAP27 RASAL2

2.89e-03881254IPR008936
Domain-

ARFGEF2 FRYL ARMC9 PPP2R1B ARVCF FHOD1

3.83e-0322212561.25.10.10
DomainRasGAP

DAB2IP RASAL2

3.84e-03141252SM00323
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH8

3.84e-03141252IPR024317
DomainDynein_HC_stalk

DNAH5 DNAH8

3.84e-03141252IPR024743
DomainDynein_heavy_dom-2

DNAH5 DNAH8

3.84e-03141252IPR013602
DomainDHC_N2

DNAH5 DNAH8

3.84e-03141252PF08393
DomainATPase_dyneun-rel_AAA

DNAH5 DNAH8

3.84e-03141252IPR011704
DomainMT

DNAH5 DNAH8

3.84e-03141252PF12777
DomainAAA_8

DNAH5 DNAH8

3.84e-03141252PF12780
DomainRasGAP_CS

DAB2IP RASAL2

3.84e-03141252IPR023152
DomainAAA_5

DNAH5 DNAH8

3.84e-03141252PF07728
DomainDHC_fam

DNAH5 DNAH8

4.41e-03151252IPR026983
DomainRasGAP

DAB2IP RASAL2

4.41e-03151252PF00616
DomainRAS_GTPASE_ACTIV_1

DAB2IP RASAL2

4.41e-03151252PS00509
DomainFH2

FHOD1 FMNL1

4.41e-03151252PS51444
DomainDynein_heavy

DNAH5 DNAH8

4.41e-03151252PF03028
DomainFH2_Formin

FHOD1 FMNL1

4.41e-03151252IPR015425
DomainFH2

FHOD1 FMNL1

4.41e-03151252PF02181
DomainRAS_GTPASE_ACTIV_2

DAB2IP RASAL2

4.41e-03151252PS50018
DomainDynein_heavy_dom

DNAH5 DNAH8

4.41e-03151252IPR004273
DomainFH2

FHOD1 FMNL1

4.41e-03151252SM00498
DomainGRAM

TBC1D9B TBC1D9

5.01e-03161252SM00568
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 CDH1 PCDHGC3 PCDH8

1.36e-1174135910817752
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3 PCDH8

2.54e-1068135811230163
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3 PCDH8

4.06e-1072135810380929
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3 PCDH8

7.02e-1077135810835267
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3 PCDH8

9.58e-1080135810716726
Pubmed

Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.

PCDHB13 PCDHB12 PCDHB11 PCDHB4 CDH1

4.87e-0917135518279309
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3

9.43e-0857135632633719
Pubmed

CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3

1.05e-0758135630377227
Pubmed

Protocadherins.

PCDHB13 PCDHB11 PCDHB4 PCDH8

1.51e-0713135412231349
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DAB2IP PPP1R12A CHD8 PRDX2 RTN1 NLGN3 AKAP9 ARVCF PI4KA TNKS SSH2 TNS1 NOS1 PCDH8 KDM1A RASAL2 DNM2

2.18e-079631351728671696
Pubmed

Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.

PPP1R12A PPP1R12B CDH1

5.69e-075135331883643
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DAB2IP CCDC22 CEP85 PPP1R12B RNF213 PSMD11 SHOC2 AKAP9 PTPRK ARVCF PI4KA NUP210 KIF14 SSH2 PLEKHA7 TNS1 NBR1

7.13e-0710491351727880917
Pubmed

The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.

PCDHB13 PCDHB12 PCDHB11 PCDHB4

1.00e-0620135411322959
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

COL6A1 RNF213 TEP1 CARD8 NUP210 PLD2 PLEC DNAH5

2.04e-06214135822199357
Pubmed

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.

SPRY1 FAT4 PPP1R12A CDH1

3.04e-0626135421303848
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PPP1R12A SAMD4B RNF213 ATP9B FRYL INTS3 TEP1 PLEKHG4B NLGN3 PPP2R1B EXD3 THADA THRA THRB ENTPD1 NUP210 GNAZ DOCK6 NBR1

5.15e-0614891351928611215
Pubmed

Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems.

PCDHB13 PCDHB12 PCDHB11

6.73e-0610135322969705
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

TBC1D9B PPP1R12A CFTR PSMD11 PRDX2 PPP2R1B THADA NUP210 C3 PLEC CDH1 DNM2

8.97e-066471351226618866
Pubmed

Loss-of-function mutations in FREM2 disrupt eye morphogenesis.

COL6A1 FREM2 CDH1

9.22e-0611135330802441
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

CEP85 SAMD4B FRYL AKAP9 KIF14 CEP295 DOCK6 PLEKHA7 FMNL1 RASAL2

1.03e-054461351024255178
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PPP1R12A PPP1R12B ARFGEF2 PRDX2 RTN1 DHX15 NLGN3 ARVCF PI4KA SSH2 UQCRFS1 PLEC GNAZ PLEKHA7 TNS1 NOS1 RASAL2 DNM2

1.13e-0514311351837142655
Pubmed

Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis.

CFTR NOS1

1.50e-052135214760158
Pubmed

Neurodevelopmental control by thyroid hormone receptors.

THRA THRB

1.50e-052135211861164
Pubmed

Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.

THRA THRB

1.50e-052135222570333
Pubmed

cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.

PDE8A PDE8B

1.50e-052135222232524
Pubmed

Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system.

THRA THRB

1.50e-052135210430610
Pubmed

Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice.

THRA THRB

1.50e-052135211496110
Pubmed

Thyroid hormone receptor-α deletion decreases heart function and exercise performance in apolipoprotein E-deficient mice.

THRA THRB

1.50e-052135226672044
Pubmed

Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.

THRA THRB

1.50e-052135221622534
Pubmed

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.

THRA THRB

1.50e-052135210346821
Pubmed

Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing.

THRA THRB

1.50e-05213529861043
Pubmed

Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser.

PPP1R12A PPP1R12B

1.50e-052135210200412
Pubmed

Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ.

THRA THRB

1.50e-052135238889231
Pubmed

Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors.

THRA THRB

1.50e-052135211739587
Pubmed

The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.

PDE8A PDE8B

1.50e-052135221187369
Pubmed

Impaired hair growth and wound healing in mice lacking thyroid hormone receptors.

THRA THRB

1.50e-052135225254665
Pubmed

Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism.

THRA THRB

1.50e-052135219282388
Pubmed

Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis.

THRA THRB

1.50e-052135220141582
Pubmed

Compensatory role of thyroid hormone receptor (TR) alpha 1 in resistance to thyroid hormone: study in mice with a targeted mutation in the TR beta gene and deficient in TR alpha 1.

THRA THRB

1.50e-052135212750454
Pubmed

Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers.

DAB2IP RASAL2

1.50e-052135227974415
Pubmed

Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice.

THRA THRB

1.50e-052135238757582
Pubmed

Naturally Occurring Amino Acids in Helix 10 of the Thyroid Hormone Receptor Mediate Isoform-Specific TH Gene Regulation.

THRA THRB

1.50e-052135228911178
Pubmed

Hormone selectivity in thyroid hormone receptors.

THRA THRB

1.50e-052135211222741
Pubmed

Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.

THRA THRB

1.50e-052135216781732
Pubmed

Lack of mutations in the thyroid hormone receptor (TR) alpha and beta genes but frequent hypermethylation of the TRbeta gene in differentiated thyroid tumors.

THRA THRB

1.50e-052135217911173
Pubmed

Effects of thyroid hormone receptor gene disruption on myosin isoform expression in mouse skeletal muscles.

THRA THRB

1.50e-052135210848522
Pubmed

Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors.

THRA THRB

1.50e-052135215780976
Pubmed

Functional activation of cerebral metabolism in mice with mutated thyroid hormone nuclear receptors.

THRA THRB

1.50e-052135212933686
Pubmed

TRα protects against atherosclerosis in male mice: identification of a novel anti-inflammatory property for TRα in mice.

THRA THRB

1.50e-052135224797634
Pubmed

Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene.

THRA THRB

1.50e-052135211726557
Pubmed

Functions of thyroid hormone receptors in mice.

THRA THRB

1.50e-052135210691312
Pubmed

Erythroid defects in TRalpha-/- mice.

THRA THRB

1.50e-052135218203951
Pubmed

Establishment of yeast reporter assay systems to detect ligands of thyroid hormone receptors alpha and beta.

THRA THRB

1.50e-052135219853653
Pubmed

New Insights into the Structure and Function of the Thyroid Hormone Receptor.

THRA THRB

1.50e-052135211725045
Pubmed

Thyroid hormone receptor {alpha} modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism.

THRA THRB

1.50e-052135220194731
Pubmed

Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors.

THRA THRB

1.50e-052135211113349
Pubmed

Locomotor deficiencies and aberrant development of subtype-specific GABAergic interneurons caused by an unliganded thyroid hormone receptor alpha1.

THRA THRB

1.50e-052135218287507
Pubmed

The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins.

THRA THRB

1.50e-052135224325866
Pubmed

Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1.

THRA THRB

1.50e-052135212356724
Pubmed

The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production.

THRA THRB

1.50e-05213529250685
Pubmed

Differential expression of thyroid hormone receptor isoforms dictates the dominant negative activity of mutant Beta receptor.

THRA THRB

1.50e-052135212198244
Pubmed

Isometric force and endurance in skeletal muscle of mice devoid of all known thyroid hormone receptors.

THRA THRB

1.50e-052135212562961
Pubmed

The c-erb-A gene encodes a thyroid hormone receptor.

THRA THRB

1.50e-05213522879243
Pubmed

Distinct behavioral phenotypes in male mice lacking the thyroid hormone receptor α1 or β isoforms.

THRA THRB

1.50e-052135223567476
Pubmed

Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis.

THRA THRB

1.50e-052135219549593
Pubmed

Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.

PDE8A PDE8B

1.50e-052135212681444
Pubmed

Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling.

THRA THRB

1.50e-052135229753845
Pubmed

Thyroxine-thyroid hormone receptor interactions.

THRA THRB

1.50e-052135215466465
Pubmed

Isometric force and endurance in soleus muscle of thyroid hormone receptor-alpha(1)- or -beta-deficient mice.

THRA THRB

1.50e-052135210712278
Pubmed

cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.

PDE8A PDE8B

1.50e-052135236277728
Pubmed

Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice.

THRA THRB

1.50e-052135212776178
Pubmed

The ability of thyroid hormone receptors to sense t4 as an agonist depends on receptor isoform and on cellular cofactors.

THRA THRB

1.50e-052135224673558
Pubmed

Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro.

THRA THRB

1.50e-052135237992217
Pubmed

Role of thyroid hormone receptor subtypes α and β on gene expression in the cerebral cortex and striatum of postnatal mice.

THRA THRB

1.50e-052135223493375
Pubmed

Regulation of neonatal Sertoli cell development by thyroid hormone receptor alpha1.

THRA THRB

1.50e-052135215858214
Pubmed

Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy.

THRA THRB

1.50e-052135220090848
Pubmed

Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.

PDE8A CFTR

1.50e-052135234936285
Pubmed

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.

THRA THRB

1.50e-05213529927422
Pubmed

Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma.

THRA THRB

1.50e-052135220062085
Pubmed

Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor alpha1.

THRA THRB

1.50e-052135217932484
Pubmed

Thyroid hormone receptor alpha plays an essential role in the normalisation of adult-onset hypothyroidism-related hypoexpression of synaptic plasticity target genes in striatum.

THRA THRB

1.50e-052135219094093
Pubmed

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha.

THRA THRB

1.50e-052135211120878
Pubmed

Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors.

THRA THRB

1.50e-052135211867729
Pubmed

Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms.

THRA THRB

1.50e-052135219131509
Pubmed

Thyroid hormone receptors are down-regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock.

THRA THRB

1.50e-052135220736347
Pubmed

Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-beta or both alpha1 and beta.

THRA THRB

1.50e-052135210362681
Pubmed

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.

THRA THRB

1.50e-052135211481455
Pubmed

Gene specific actions of thyroid hormone receptor subtypes.

THRA THRB

1.50e-052135223300972
Pubmed

Thyroid Hormone Receptors Are Differentially Expressed in Granulosa and Cervical Cells of Infertile Women.

THRA THRB

1.50e-052135226715425
Pubmed

Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies.

THRA THRB

1.50e-052135219903799
Pubmed

Cardiac glucose utilization in mice with mutated alpha- and beta-thyroid hormone receptors.

THRA THRB

1.50e-052135215304375
Pubmed

Functionally impaired TR mutants are present in thyroid papillary cancer.

THRA THRB

1.50e-052135211889175
Pubmed

Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles.

THRA THRB

1.50e-05213521517709
Pubmed

Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta.

THRA THRB

1.50e-052135216051666
Pubmed

The thyroid hormone receptors as modulators of skin proliferation and inflammation.

THRA THRB

1.50e-052135221566120
Pubmed

Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct.

NOS1 DNM2

1.50e-052135226791826
Pubmed

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.

THRA THRB

1.50e-052135229229863
Pubmed

Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes.

THRA THRB

1.50e-052135218844476
Pubmed

Gaining ligand selectivity in thyroid hormone receptors via entropy.

THRA THRB

1.50e-052135219926848
Pubmed

Thyroid Hormone Receptor α Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury.

THRA THRB

1.50e-052135226451739
InteractionCLEC4A interactions

DAB2IP PCDHB13 ARFGEF2 RNF213 THADA PTPRK LRRN2 CDH1 PCDHGC3

1.92e-081031289int:CLEC4A
InteractionKRT8 interactions

CCDC22 CEP85 RNF31 CFTR NUP88 THADA THRB AKAP9 KRT75 KIF14 PLEC CDH1 NBR1 CLUH

8.44e-0744112814int:KRT8
InteractionZBBX interactions

FAT4 FAT3 FANCM FREM2 DNM2

1.42e-06311285int:ZBBX
InteractionKRT19 interactions

CCDC22 CEP85 RNF31 CFTR PCDHB12 NUP88 AKAP9 KRT75 CEP295 PLEC KDM1A

1.90e-0628212811int:KRT19
InteractionXAGE1A interactions

FAT4 FAT3 CHD8 FREM2 PCDHGC3

5.96e-06411285int:XAGE1A
InteractionSIGLECL1 interactions

TBC1D9B ARFGEF2 RNF213 INTS3 THADA CDK5RAP3 KIF14

7.81e-061131287int:SIGLECL1
InteractionLGALS1 interactions

FAT4 FAT3 CFTR PLXNB2 NLGN3 FREM2 PTPRK KIF14 UQCRFS1 NBR1 CLUH

9.01e-0633212811int:LGALS1
InteractionCD160 interactions

FAT4 FAT3 PLXNB2 THRA PTPRK

1.31e-05481285int:CD160
InteractionC19orf38 interactions

TBC1D9B CFTR RNF213 TBC1D9 THADA KIF14

1.81e-05861286int:C19orf38
InteractionCARD16 interactions

FAT4 FAT3 CARD8

2.04e-0591283int:CARD16
InteractionSYNE3 interactions

CEP85 SAMD4B NUP88 GXYLT1 RTN1 NUP210 KIF14 CEP295 PLEC PLEKHA7 NBR1 CLUH

2.67e-0544412812int:SYNE3
InteractionTBC1D8B interactions

TBC1D9B TBC1D9 KIF14

3.98e-05111283int:TBC1D8B
InteractionCTAG2 interactions

TBC1D9B RNF31 TBC1D9 KIF14

6.98e-05351284int:CTAG2
InteractionDAAM1 interactions

CFTR KIF14 GNAZ CDH1 FMNL1

9.51e-05721285int:DAAM1
InteractionPLEC interactions

CFTR NUP88 FANCM THRB KIF14 PLEC DNA2 CDH1 DNAH5 FMNL1 KDM1A

9.54e-0543012811int:PLEC
Cytoband5q31

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3

5.75e-0811513675q31
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE17 SPDYE10 SPDYE9 SPDYE11 SPDYE13 SPDYE15 SPDYE8 SPDYE14

1.63e-062711368chr7q11
CytobandEnsembl 112 genes in cytogenetic band chr5q31

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3

3.23e-052981367chr5q31
Cytoband7q11.23

SPDYE10 SPDYE9 SPDYE8 SPDYE14

2.06e-049713647q11.23
CytobandEnsembl 112 genes in cytogenetic band chr17q21

CNTD1 CDK5RAP3 THRA OSBPL7 ARHGAP27 NBR1 FMNL1

5.50e-044731367chr17q21
Cytoband4q28.1

SPRY1 FAT4

1.02e-031613624q28.1
GeneFamilyClustered protocadherins

PCDHGB3 PCDHB13 PCDHB12 PCDHB11 PCDHB4 PCDHA6 PCDHGC3

5.34e-086498720
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG4B OSBPL7 GAB3 ARHGAP27 PLEKHA7 RASAL2 DNM2

1.30e-04206987682
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

DAB2IP RASAL2

1.27e-0310982830
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARMC9 THADA ARVCF

1.63e-0343983409
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE9 SPDYE8

1.85e-0312982756
GeneFamilyWD repeat domain containing|GRAM domain containing|BEACH domain containing

TBC1D9B TBC1D9

2.18e-03139821146
GeneFamilyDyneins, axonemal

DNAH5 DNAH8

3.75e-0317982536
GeneFamilyCadherin related

FAT4 FAT3

3.75e-031798224
CoexpressionFAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_2

COL6A1 SPRY1 PDE8A PPP1R12A GGT1 ITIH5 PTPRK PDE8B DOCK6 TNS1

2.88e-0630313010M39040
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

ERN1 PPP1R12B GXYLT1 FRYL PSMD11 THRB KIF14 TNKS

3.37e-061801308M8239
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500

ZSWIM5 FAT3 ARFGEF2 FRYL RTN1 FREM2 AKAP9 ARVCF NUP210 CEP295 CDH1 RASAL2

4.54e-0549812712Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_500

FAT4 TMEM169 ZSWIM5 PPP1R12A FAT3 CFTR PCDHB13 PCDHB12 PCDHB11 ARFGEF2 RTN1

5.26e-0542712711DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_200

COL6A1 FAT3 PCDHB13 CHD8 ITIH5 PTPRK CEP295

6.40e-051661277gudmap_developingGonad_e16.5_epididymis_200
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000

SPRY1 PDE8A ZSWIM5 FAT3 CHD8 FRYL FANCM RTN1 NLGN3 THRA AKAP9 ARVCF PDE8B NUP210 PPIP5K1 CDH1 RASAL2

8.20e-0598612717Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#4_top-relative-expression-ranked_500

COL6A1 FAT3 PCDHB13 PCDHB11 GGT1 ITIH5 PTPRK

8.92e-051751277gudmap_developingGonad_e14.5_ epididymis_500_k4
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

ARFGEF2 TBC1D9 DHX15 PI4KA ENTPD1 NUP210 ARHGAP27 CDH1

1.30e-07196132809d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFTR ARMC9 TEP1 CNTD1 CLUH DNM2 MITD1

1.13e-06180132781d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 MYO7B FAT3 CFTR PKHD1L1 FREM2 DNAH5

1.31e-0618413272cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 MYO7B FAT3 CFTR PKHD1L1 FREM2 DNAH5

1.31e-061841327ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 MYO7B FAT3 CFTR PKHD1L1 FREM2 DNAH5

1.31e-0618413272b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PDE8A MCF2L2 ATP9B ARMC9 SSH2 PLEKHA7 RASAL2

1.80e-061931327779276e775cb2492e8dd36436295a536084a6415
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SPRY1 FAT3 SHOX2 RTN1 FREM2 TNKS PCDHGC3

1.86e-0619413278b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PLXNB2 AKAP9 FHOD1 C3 PLEKHA7 CDH1 DNM2

2.06e-0619713273d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ERN1 CFTR PLXNB2 SEC24D AKAP9 C3 CDH1

2.13e-061981327285f729140b1df029c24f6ca1d2438470ac51794
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons|GW26 / Sample Type, Dataset, Time_group, and Cell type.

TMEM169 TTC9B RTN1 THRA THRB AKAP9 GNAZ

2.28e-062001327bad32a95b759fad509401b07bc96a56687c2a592
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 PPP1R12B CFTR ITIH5 LRRN2 DOCK6

1.03e-0516613266d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

SHOX2 PLXNB2 PLEKHG4B GAB3 ARHGAP27 CDH1

1.39e-05175132629fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM169 MCF2L2 RTN1 ARVCF KCNJ5 NOS1

1.73e-051821326be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

CFTR FREM2 PTPRK C3 PLEKHA7 CDH1

1.84e-051841326369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

CFTR PLEKHG4B PTPRK PLEKHA7 CDH1 DNAH5

1.90e-051851326cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PCDHGB3 PCDHB11 PRDX2 SPDYE8 UQCRFS1 PCDHGC3

1.96e-05186132610edc3dd96181b6f7bd07a5ad0862ba9fa6a9cb9
ToppCelldroplet-Marrow-BM-30m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEP1 PLXNB2 F13A1 NUP210 PLEC DNA2

1.96e-051861326bcb3ac9f9b51346e0a2b0bda96d149b3c11f7883
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL6A1 TRO PCDHB11 NLGN3 THRB LRRN2

2.02e-051871326ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCellmoderate-Epithelial-Ionocyte|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FAT3 PPP1R12B CFTR TMOD4 ITIH5 RASSF6

2.02e-0518713263e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERN1 CFTR SEC24D C3 PLEKHA7 CDH1

2.08e-0518813264bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FAT3 PPP1R12B CFTR TMOD4 ITIH5 RASSF6

2.14e-0518913266011b747e27d61d222380a7bffdd921a68e9b657
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP FAT4 TRO DOCK6 PCDHGC3 RASAL2

2.41e-051931326826b8dd801298b3e0cd76232feae5a14026b8806
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP FAT4 TRO DOCK6 PCDHGC3 RASAL2

2.41e-05193132687d3a577d37fb0cb4b6313c596310de452bc3872
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP FAT4 TRO DOCK6 PCDHGC3 RASAL2

2.41e-051931326d485634c564b268e344b6a2863c26f6adaec9e38
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

CFTR ARMC9 FREM2 THRB PTPRK C3

2.41e-051931326738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellsevere-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FANCM PKHD1L1 FCRL1 THRB RASSF6 DNAH8

2.48e-0519413262fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCellsevere-B_cell|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FANCM PKHD1L1 FCRL1 THRB RASSF6 DNAH8

2.55e-0519513260fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCellMonocytes-cDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

ARRDC4 PLXNB2 RTN1 F13A1 TBC1D9 ENTPD1

2.70e-0519713263388c104af4c6a05988e102627e0c5e34d9dcc45
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs|3_mon / Sample Type, Dataset, Time_group, and Cell type.

TTC9B FAT3 RTN1 PTPRK GNAZ HS3ST1

2.78e-05198132660d8d3bbd754ffde41c50013d822667b185a9751
ToppCellParenchymal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SPRY1 FAT3 SHOX2 ZBTB34 PIGX DOCK6

2.86e-0519913266f5ef959b51eccf1ffc2e5ddf0d83c62ca2257b2
ToppCellParenchymal-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SPRY1 FAT3 SHOX2 ZBTB34 PIGX DOCK6

2.86e-0519913261aa99d21bf61b86df4a966dc47634044430aa39f
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ERN1 CFTR SEC24D AKAP9 C3 CDH1

2.94e-052001326e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

COL6A1 SPRY1 FAT4 PPP1R12B NLGN3 GAB3

2.94e-052001326a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

TRIM68 FREM2 PDE8B C3 PLEKHA7 CDH1

2.94e-052001326eac33be484dc443794e66e473f03e98406c2983e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ENTPD1 GAB3 C3 SSH2 ARHGAP27 PLEC

2.94e-05200132680e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

TTC9B FAT3 RTN1 AKAP9 PTPRK GNAZ

2.94e-052001326db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

TTC9B FAT3 RTN1 AKAP9 PTPRK GNAZ

2.94e-05200132630a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

TTC9B RTN1 THRA GNAZ HS3ST1 PCDH8

2.94e-05200132671cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 SPRY1 FAT4 F13A1 ITIH5 ENTPD1

2.94e-052001326fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 SPRY1 FAT4 F13A1 ITIH5 ENTPD1

2.94e-05200132658b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFTR RTN1 TBC1D9 ENO4 DNAH5

9.60e-0515413251e32969bee810adaf2d560f0824a16227df513d8
ToppCellIonocyte|World / shred by cell class for nasal brushing

FAT4 PPP1R12B CFTR ITIH5 DHX15

9.60e-0515413256b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high|E18.5-samps / Age Group, Lineage, Cell class and subclass

PCDHA6 CHD8 INTS3 MOCS3 HS3ST1

9.60e-051541325212c340a096a3a9669d1aebd61c045cf1402a868
ToppCellfacs-Trachea-24m-Hematologic-myeloid-granulocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARRDC4 FAT3 ENTPD1 GNAZ FMNL1

1.05e-041571325188d2f85babcd4eefe20e7a392d851b2e1185bab
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM169 MYO7B FAT3 CFTR PKHD1L1

1.15e-041601325c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM169 MYO7B FAT3 CFTR PKHD1L1

1.15e-04160132525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TMEM169 MYO7B THADA ENTPD1 PLEKHA7

1.18e-04161132522fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 PPP1R12B CFTR PRDX2 ITIH5

1.22e-0416213259a18286e361e1dd18e6f943ce27db58b199fb6e4
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 PPP1R12B CFTR PRDX2 ITIH5

1.22e-0416213253395e4dffdb9304d157c325e1fc0f12b433c7bd3
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 PPP1R12B CFTR PRDX2 ITIH5

1.22e-0416213259522af31f6b2f3cb81b6b84bd08353eea504d1d6
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 PPP1R12B CFTR PRDX2 ITIH5

1.22e-04162132540265af9b36fd144a8577b8dacccd4fc0888a593
ToppCellcontrol-Epithelial-Ionocyte|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FAT3 PPP1R12B CFTR ITIH5 DOCK6

1.33e-0416513255cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 CFTR ARVCF C3 CEP295

1.36e-04166132560060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 CFTR ARVCF C3 CEP295

1.36e-041661325ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 CFTR ARVCF C3 CEP295

1.36e-0416613254586d6725403f879fc96f67be579022587ce1906
ToppCellNS-critical-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 PPP1R12B CFTR PCDHB13 ITIH5

1.44e-0416813256a233045638cb83dab64789b996b7598c325001e
ToppCellIonocyte|World / Class top

CFTR PCDHB4 PLCD4 ITIH5 ENTPD1

1.52e-041701325d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCellBL-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT4 CFTR PCDHB13 TMOD4 ITIH5

1.52e-041701325b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A1 PCDHGB3 SHOX2 C3 PCDHGC3

1.61e-041721325e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A1 TMOD4 PKHD1L1 FREM2 C3

1.65e-04173132530d67738633493d47f06ae452424382f069b6c0a
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFTR PCDHB12 TMOD4 FREM2 RASSF6

1.70e-041741325b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFTR PCDHB12 TMOD4 FREM2 RASSF6

1.70e-04174132571730503be3d9c839c4c9e950145e2101d682a1c
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFTR PCDHB12 TMOD4 FREM2 RASSF6

1.70e-041741325ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFTR PCDHB12 TMOD4 FREM2 RASSF6

1.70e-041741325cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A1 TMOD4 PKHD1L1 FREM2 C3

1.70e-041741325a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEP1 PLXNB2 F13A1 C3 DNA2

1.75e-04175132569b59ec58e64644deb7e07f31ef495ef4a6f6276
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFTR THRB NUP210 CDH1 CLUH

1.75e-0417513256759d200a133034756de9cdf2d5daceca927aac9
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEP1 PLXNB2 F13A1 C3 DNA2

1.75e-0417513254f7498b5a0ed52c348a5f94bcd41d830ba7954ea
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

SHOX2 PLXNB2 PLEKHG4B GAB3 CDH1

1.79e-041761325d6e660df92a3d7dd5732171ee623763faf108476
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 PCDHGB3 PCDHB11 PLCD4 ITIH5

1.84e-041771325bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)|343B / Donor, Lineage, Cell class and subclass (all cells)

COL6A1 FAT4 TRO PCDHB4 PDE8B

1.84e-041771325e55d21d4d61a069b9bbe0e7595fbfb7cfbacfd87
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 PCDHB12 PLCD4 PCDHA6 PCDHGC3

1.84e-0417713258220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-|343B / Donor, Lineage, Cell class and subclass (all cells)

COL6A1 FAT4 TRO PCDHB4 PDE8B

1.84e-04177132543ba6f12c2fb32698a420bf799d46ac1b558f146
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCD4 TRIM68 ZBTB34 PTPRK PDE8B

1.84e-0417713257c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 PPP1R12B CFTR ITIH5 RASSF6

1.84e-04177132599500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 PCDHB12 PLCD4 PCDHA6 PCDHGC3

1.84e-0417713257617270f49cd6b7ba66db72d20560cee985012b2
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCD4 TRIM68 ZBTB34 PTPRK PDE8B

1.84e-041771325e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SPRY1 PKHD1L1 FCRL1 PTPRK HS3ST1

1.84e-0417713253535575686c9700ab72700aae6f2070ebbb50044
ToppCellB_cells-Naive_B_cells_|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SPRY1 MYO7B FCRL1 PTPRK GNAZ

1.89e-04178132571ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLXNB2 SEC24D C3 PLEKHA7 CDH1

1.94e-041791325fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 PPP1R12B CFTR TMOD4 ITIH5

1.99e-0418013258af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 CFTR TMOD4 ITIH5 RASSF6

1.99e-0418013255286e66ff6b7154390b3e9c189704a71d56bc89c
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 CFTR TMOD4 ITIH5 RASSF6

1.99e-0418013252b6b295b5c21b829828afae9ab4c3eb9233f6f45
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 CFTR TMOD4 ITIH5 RASSF6

1.99e-041801325bf587387145a2b5e83766fbccf76eecc6d5e8241
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYO7B CFTR EXD3 CYP4F12 CDH1

2.04e-0418113251d3d1b5a6efe9cedd03b7e0b5684df97f0246729
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PPP1R12B CFTR TMOD4 ITIH5 RASSF6

2.04e-04181132540df0afcb6848202da54670e84f22d7c3a515d01
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 FCRL1 PTPRK DNAH8 PCDHGC3

2.04e-041811325700adfb41e4e377530f0dd31be89e12f109f3469
ToppCellfacs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC24D ARHGAP27 HS3ST1 CDH1 TNS1

2.04e-041811325782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PPP1R12B CFTR TMOD4 ITIH5 RASSF6

2.04e-0418113252b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 PPP1R12B PLCD4 ITIH5 TNS1

2.04e-041811325ab0f300d14b62cef57f1b0bdae143b8dfe8e6975
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PPP1R12B CFTR TMOD4 ITIH5 RASSF6

2.04e-0418113256aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCellfacs-Marrow-B-cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC24D ARHGAP27 HS3ST1 CDH1 TNS1

2.04e-041811325e2481291c236105774c53883e6f20da11941df9b
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYO7B CFTR EXD3 CYP4F12 CDH1

2.04e-0418113250069e8308de932df43660bbe926637c57b8bf7f6
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PPP1R12B CFTR TMOD4 ITIH5 RASSF6

2.04e-04181132540d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CFTR FREM2 PTPRK CDH1 DNAH5

2.04e-041811325c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A1 ITIH5 SEC24D C3 LRRN2

2.09e-041821325f4b74c2756989812abe4e7055ec8918f69d56025
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 PPP1R12B CFTR ITIH5 RASSF6

2.15e-041831325ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellMild-Lymphoid-B|Mild / Condition, Lineage, Cell class and cell subclass

PKHD1L1 FCRL1 PTPRK DNAH8 PCDHGC3

2.15e-0418313259b64d2d143525e6f48a191facfd101462ff36324
ToppCellMild_COVID-19-B_cell|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PKHD1L1 FCRL1 PTPRK DNAH8 PCDHGC3

2.15e-041831325dea119e2988e954475f557f0bbe12556a83e81a4
ToppCell3'_v3-blood-Lymphocytic_B-Memory_B_cells|blood / Manually curated celltypes from each tissue

PKHD1L1 TBC1D9 FCRL1 RASSF6 DNAH8

2.15e-041831325e3a418b745d7f040adf47be9e1043b945cae47ed
DrugCatechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A

COL6A1 THRA PDE8B KCNJ5 NUP210 C3 CYP4F12 GNAZ RASAL2

1.94e-0619613093351_DN
DrugAllantoin [97-59-6]; Up 200; 25.2uM; MCF7; HT_HG-U133A

CEP85 PPP2R1B THRB ARVCF TNKS PLD2 DOCK6 CDH1 RASAL2

2.02e-0619713091678_UP
DrugPirlindole mesylate [60762-57-4]; Down 200; 12.4uM; MCF7; HT_HG-U133A

COL6A1 ARFGEF2 SHOX2 ARVCF PDE8B ENTPD1 PLEC CDH1

1.80e-0519713086519_DN
DrugColistin sulfate [1264-72-8]; Down 200; 3uM; MCF7; HT_HG-U133A

CCDC22 PSMD11 THRA ENTPD1 PLD2 PLEC NOS1 DNM2

1.80e-0519713084796_DN
DrugMethimazole [60-56-0]; Down 200; 35uM; MCF7; HT_HG-U133A

FAT4 CFTR SHOX2 SEC24D THRA THRB C3 PLD2

1.86e-0519813083898_DN
DrugCortisone [53-06-5]; Up 200; 11uM; HL60; HT_HG-U133A

PPP2R1B THRB AKAP9 KRT75 PDE8B OSBPL7 PLD2 NOS1

1.86e-0519813082385_UP
DrugBetaxolol hydrochloride [63659-19-8]; Up 200; 11.6uM; HL60; HG-U133A

CEP85 F13A1 PPP2R1B THADA THRA THRB PLD2 NOS1

1.86e-0519813081592_UP
DrugHexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; PC3; HT_HG-U133A

COL6A1 CCDC22 SEC24D THADA PDE8B NUP210 GNAZ TNS1

1.86e-0519813085768_DN
DrugDiflunisal [22494-42-4]; Down 200; 16uM; MCF7; HT_HG-U133A

TBC1D9B EXD3 THRA ARVCF NUP210 PLD2 NOS1 RASAL2

1.86e-0519813084794_DN
DrugSulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; PC3; HT_HG-U133A

CCDC22 ATP9B CARD8 AKAP9 NUP210 PLEC CDH1 DNM2

1.93e-0519913081817_DN
DrugLevothyroxine

THRA THRB

3.24e-0521302DB00451
DrugLiothyronine

THRA THRB

3.24e-0521302DB00279
DrugLiotrix

THRA THRB

3.24e-0521302DB01583
Drug3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid

THRA THRB

3.24e-0521302DB03176
DrugKB 130015

THRA THRB

3.24e-0521302ctd:C446946
DrugRafoxanide

THRA THRB

3.24e-0521302ctd:D011888
Diseasecoronary artery disease

DAB2IP FAT4 PPP1R12B CFTR ARFGEF2 TMOD4 RNF213 APOA4 F13A1 PPP2R1B THADA ARVCF NUP210 TNKS DOCK6 PLEKHA7 TNS1

1.09e-05119412417EFO_0001645
Diseasecortical thickness

PDE8A ARRDC4 FAT3 PCDHB11 ARFGEF2 ITIH5 ENO4 ZBTB34 THADA CBY2 PI4KA SSH2 PLEC PLEKHA7 TNS1 CLUH

1.79e-05111312416EFO_0004840
Diseasethyroid hormone resistance syndrome (implicated_via_orthology)

THRA THRB

5.24e-0531242DOID:11633 (implicated_via_orthology)
Diseasemajor depressive disorder (biomarker_via_orthology)

APOA4 NOS1

5.24e-0531242DOID:1470 (biomarker_via_orthology)
DiseaseHeterotopia, Periventricular, Autosomal Recessive

FAT4 ARFGEF2

5.24e-0531242C1842563
Diseasediabetic retinopathy (is_marker_for)

APOA4 F13A1 GGT1 KDM1A

7.99e-05541244DOID:8947 (is_marker_for)
Diseasenephrotic syndrome type 20 (implicated_via_orthology)

TBC1D9B TBC1D9

1.05e-0441242DOID:0070357 (implicated_via_orthology)
DiseaseGeneralized Thyroid Hormone Resistance

THRA THRB

1.05e-0441242C4722330
Diseaseneuroimaging measurement

PDE8A ARRDC4 FAT3 FRYL ARMC9 PLXNB2 ITIH5 ENO4 THADA SSH2 ARHGAP27 PLEC PLEKHA7 TNS1

1.65e-04106912414EFO_0004346
Diseasecardiovascular disease biomarker measurement, ankle brachial index

FAT3 DNAH5

1.74e-0451242EFO_0003912, EFO_0005278
DiseaseCarcinoma, Lobular

PPP1R12B CDH1

2.60e-0461242C0206692
Diseasecervix uteri carcinoma in situ (is_implicated_in)

THRB CDH1

3.63e-0471242DOID:8991 (is_implicated_in)
Diseasecortical surface area measurement

SPRY1 PDE8A ARRDC4 FAT3 PPP1R12B FRYL PLXNB2 ITIH5 THADA TNKS SSH2 ARHGAP27 PLEKHA7 TNS1 KDM1A

5.32e-04134512415EFO_0010736
DiseaseDiaphragmatic Hernia

CFTR THRA THRB

6.87e-04411243C0019284
DiseaseMacrocephaly

CHD8 THRA

9.40e-04111242C0221355
DiseaseCongenital long QT syndrome

AKAP9 KCNJ5

9.40e-04111242cv:C1141890
DiseaseLong QT syndrome

AKAP9 KCNJ5

1.12e-03121242cv:C0023976
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

DAB2IP PLXNB2 RASAL2

1.16e-03491243DOID:0060037 (implicated_via_orthology)
Diseasenodular sclerosis Hodgkin lymphoma

UPF3A PTPRK

1.54e-03141242EFO_0004708
Diseaseprostate carcinoma, type 2 diabetes mellitus

THADA OSBPL7 LRRN2

1.98e-03591243EFO_0001663, MONDO_0005148
Disease5-oxoproline measurement

DNAH8 OPLAH

2.02e-03161242EFO_0010988
DiseaseRomano-Ward Syndrome

AKAP9 KCNJ5

2.02e-03161242C0035828
Diseasebrain measurement, neuroimaging measurement

ARRDC4 FAT3 ITIH5 ZBTB34 THADA SSH2 PLEC TNS1

2.31e-035501248EFO_0004346, EFO_0004464
Diseaseoral squamous cell carcinoma (is_marker_for)

PRDX2 DOCK6 CDH1

2.39e-03631243DOID:0050866 (is_marker_for)
Diseaserenal cell carcinoma (is_implicated_in)

THRA THRB CDH1

3.10e-03691243DOID:4450 (is_implicated_in)
Diseaselung cancer (is_implicated_in)

DAB2IP CFTR SHOX2

3.78e-03741243DOID:1324 (is_implicated_in)
DiseaseBronchiectasis

CFTR DNAH5

3.83e-03221242C0006267
DiseaseSarcosine measurement

PCDHGB3 SHOC2

4.18e-03231242EFO_0021668

Protein segments in the cluster

PeptideGeneStartEntry
VERTRSELLPFLTDT

PPP2R1B

56

P30154
DPDRALTDYITRLEA

AKAP9

3871

Q99996
EPITEERASRTLYRI

CHD8

1876

Q9HCK8
RLELSDIYQIPSVDS

CFTR

31

P13569
PEVVRLYLSLLTESR

ARVCF

661

O00192
LDRERIPSYNLTVSV

FAT4

426

Q6V0I7
VSERPRVLQEYTSDD

ARFGEF2

1301

Q9Y6D5
YSIITPNILRLESEE

C3

26

P01024
LDRPSYVASEESRIL

ASB6

36

Q9NWX5
LETLPRDVSRLAYTQ

CCDC22

481

O60826
EPERDYLEAAIRTVI

DHX15

326

O43143
SEVEYLNVRLSLREP

ARRDC4

86

Q8NCT1
DDLYRISELDRTQIP

RASSF6

136

Q6ZTQ3
VDITPYLDQLDESLR

INTS3

566

Q68E01
EEQRVLIYESRLPDS

PCDHA6

136

Q9UN73
DYVPIATDRTRLLAE

KCNJ5

31

P48544
VEELRRSLAPYAQDT

APOA4

216

P06727
IVSTTRELYLEDSPL

NUP210

121

Q8TEM1
EYPDDRTARTLTLIA

DAB2IP

541

Q5VWQ8
YTLLTERPLDRESRA

PCDHB13

401

Q9Y5F0
IDPERYRLCRQEITS

KIF14

736

Q15058
SDRPAYVTILSLVRD

NFRKB

571

Q6P4R8
DEIRTPLLSDIRIDY

ITIH5

476

Q86UX2
TRSESELLFLPDYLV

GAB3

171

Q8WWW8
VYPEGTLELRRVTAE

LRRN2

476

O75325
LYSILSVPSIREEAR

ARMC9

526

Q7Z3E5
RTSTIPEELGRLVYL

ATP9B

451

O43861
QIELRSEDSPDILTY

FANCM

266

Q8IYD8
LDTDDRELRYTVTQP

FREM2

731

Q5SZK8
LARPLRTSEEPYTET

MCF2L2

561

Q86YR7
RVEYDTRVSDVPLSL

PLXNB2

1186

O15031
VLHRDYDRTVTLLSP

PCDH8

1021

O95206
DRVLEILRTTELYSP

PDE8A

416

O60658
DRVLEILRTTELYSP

PDE8B

476

O95263
TDRLVITPLTDRCYI

DNAH8

1816

Q96JB1
LSEELARAYPELTLA

FRYL

1271

O94915
DSLLYVDTDILFLRP

GXYLT1

211

Q4G148
VTLLSDVAYRDPSLR

PI4KA

136

P42356
QEYPDDRTSRTLTLI

RASAL2

496

Q9UJF2
SVDILLEYRSSENPV

F13A1

296

P00488
IVASDLEPRELSSYV

PCDHGB3

491

Q9Y5G1
DRETVPEYNLSITAR

PCDHGC3

416

Q9UN70
DRVLDVVERSLSNYP

ENTPD1

146

P49961
LSSYPRLREETERIV

DNM2

446

P50570
IPLLADVTRRLSEDY

PRDX2

101

P32119
YTLETERPLDRESRA

PCDHB12

401

Q9Y5F1
PLVDLSYDSALEVLR

NOS1

71

P29475
YTLETERPLDRESTA

PCDHB11

401

Q9Y5F2
ERPLDRESTAEYNIT

PCDHB11

406

Q9Y5F2
RLEPIRYSVLEETES

PCDHB4

26

Q9Y5E5
RPLDRETSAEYNITI

PCDHB4

406

Q9Y5E5
LLVENPRDYSTELSV

NLGN3

696

Q9NZ94
YTRKRDTRSESLEIP

CBY2

31

Q8NA61
ESSPDRRLTLSQIYE

FOXO3B

256

A0A2Z4LIS9
ADYIPTVEDILRSRD

GNAZ

166

P19086
PSDVYLSSRDRQILD

KDM1A

516

O60341
VAELYLPLLSIARDT

DOCK6

1161

Q96HP0
LEPRLSIIATDHTYR

COL6A1

196

P12109
YRELPAEVRETLGSL

ERN1

911

O75460
QRSLTAEYEIPSVRE

FCRL1

161

Q96LA6
RGPDALTLLEYTETR

CDK5RAP3

336

Q96JB5
IETLERYLADLPTLE

CEP85

476

Q6P2H3
ERPSEYIATILELSA

CYP4F12

216

Q9HCS2
FERRDYLVTVPEDTS

FAT3

3236

Q8TDW7
TALSEYRPILSQEHR

GPR157

201

Q5UAW9
VLFRSISERDPYLVS

CARD8

516

Q9Y2G2
LPTEYERSLITRFER

FMNL1

756

O95466
DVPRRLEELLNSTFY

ENO4

31

A6NNW6
LEYDPTQRITLDEAL

CLK4

456

Q9HAZ1
LVLQTRPESSDLYSE

FHOD1

866

Q9Y613
YEDRDPLRVSISREQ

CEP295

1871

Q9C0D2
LYTLLSQERRADPEA

DNA2

316

P51530
EPIYESLLRASIENS

CNTD1

221

Q8N815
LTPATALDLVRRYDV

MOCS3

161

O95396
VTEPLDRERIATYTL

CDH1

216

P12830
DRLVITPLTDRCYIT

DNAH5

1951

Q8TE73
DTEYEIRVLLTRPGE

PTPRK

356

Q15262
STDTRLRPDQRYLEE

OSBPL7

756

Q9BZF2
LTSDNVIRIYSLREP

NUP88

191

Q99567
LRDPSERVLSDYTQV

HS3ST1

146

O14792
SPSIQYSILREEREA

RTN1

446

Q16799
DSYAESRQLTLPRTE

THADA

1936

Q6YHU6
TSELALELIDRYEPS

PLCD4

241

Q9BRC7
VASERELYIPSVDLL

NBR1

541

Q14596
RAVELDSESRYPQAL

MITD1

21

Q8WV92
TNTRITDPEILESRY

OPLAH

1141

O14841
TRELIARRTTPLLEY

UPF3A

206

Q9H1J1
LTDYRAELRDDPIIS

PSMD11

306

O00231
RPLARSDSENVYEVI

ARHGAP27

191

Q6ZUM4
DSRVELRSYVSEPEL

PLEKHA7

976

Q6IQ23
LYEETRSHIPLLSEL

SPDYE10

186

P0DUX0
LYEETRSHIPLLSEL

SPDYE11

186

P0DTA3
LYEETRSHIPLLSEL

SPDYE8

186

P0DUD1
LREIPSVVYRLDSLT

SHOC2

181

Q9UQ13
EAITYREVLESGPLR

SHOX2

21

O60902
DLLSRYRLEVPESVT

SIGLEC12

146

Q96PQ1
LSRPEISTDERAYQR

SEC24D

856

O94855
LDVVLDSSARVAPYR

TBC1D9B

46

Q66K14
VVSHPRYLELLERTS

CLUH

511

O75153
YFSTLDIQLRESLEP

RNF31

761

Q96EP0
ISYEVERDLTPLILS

RNF213

4921

Q63HN8
TTILRLSLDYPQREE

ZSWIM5

931

Q9P217
RLDPDTAYSRLIVSE

TRIM68

306

Q6AZZ1
PDFSEYRRLEVLDST

UQCRFS1

86

P47985
VDPYELASLRERNIT

PIGX

91

Q8TBF5
TLYEQVSERLRTLPA

TEP1

1376

Q99973
PADDELYQRTRISLL

NDUFAF3

36

Q9BU61
PEDNIRLAVRLESTY

SSH2

86

Q76I76
LLVSRPDEENITSYL

SAMD4B

486

Q5PRF9
DDYLAQLSLEPTTRT

TRO

391

Q12816
YPQTRLRLEEALSEA

PLEKHG4B

591

Q96PX9
LYEETRSHIPLLSEL

SPDYE13

186

A0A494C0Z2
LYEETRSHIPLLSEL

SPDYE14

186

P0DUD3
LYEETRSHIPLLSEL

SPDYE15

186

P0DUD4
LYEETRSHIPLLSEL

SPDYE17

186

P0DUD2
ESTPIRTSDVDYRLL

TNKS

641

O95271
RAAVRYDPESETLTL

THRB

316

P10828
VRLSEEPRSYVESVA

TNS1

1016

Q9HBL0
DVVLDSSARVAPYRI

TBC1D9

51

Q6ZT07
RLDYEREIQPTAILS

SPRY1

26

O43609
DRLRSDYTTLLCEIP

PKHD1L1

2041

Q86WI1
RPELEDSTLRYLQDL

PLEC

651

Q15149
YRDIDEDEILRTLSP

TMOD4

11

Q9NZQ9
ESYPRRTIIIEDNRS

TIMM21

231

Q9BVV7
LYEETRSHIPLLSEL

SPDYE9

186

A0A494C191
LRAAVRYDPESDTLT

THRA

261

P10827
ESRPESIIIYRSDNE

TMEM169

46

Q96HH4
SLRTLREYVAVEPLA

PLD2

871

O14939
RTTVRLESTLYLPEL

PRRG3

166

Q9BZD7
LRYLQEARSREPTDT

TTC9B

191

Q8N6N2
PRSVDLQLYHSETLE

PPIP5K1

696

Q6PFW1
EVRSRIESPERTDVY

ZBTB34

456

Q8NCN2
ERLTLPQLADTYETL

GGT1

206

P19440
LEPLFDSYTSELRRQ

KRT75

196

O95678
DVARRYPEVTSLSLE

EXD3

216

Q8N9H8
SREDPVSTELIYRQV

MYO7B

1296

Q6PIF6
RRSYLTPVRDEESES

PPP1R12A

666

O14974
RRSYLTPVRDEEAES

PPP1R12B

616

O60237