Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microtubule motor activity	KIF27 DNAH10 DNAH17 DYNC1LI1 DNAH8	4.02e-06	70	68	5	GO:0003777
GeneOntologyMolecularFunction	ATP-dependent activity	KIF27 DNAH10 VPS4B DNAH17 DYNC1LI1 MACF1 HELZ CHD1 ATP13A2 ATP2A2 DNAH8	6.63e-06	614	68	11	GO:0140657
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH10 DNAH17 DNAH8	2.97e-05	18	68	3	GO:0008569
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF27 DNAH10 DNAH17 DYNC1LI1 DNAH8	5.13e-05	118	68	5	GO:0003774
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH10 DNAH17 DNAH8	1.16e-04	28	68	3	GO:0051959
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF27 DNAH10 VPS4B MACF1 CHD1 ATP13A2 ATP2A2 DNAH8	1.23e-04	441	68	8	GO:0016887
GeneOntologyMolecularFunction	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	INPP5B INPP5K	2.37e-04	7	68	2	GO:0052659
GeneOntologyMolecularFunction	kinase activity	CCNE1 MAK HIPK4 BRAF DGKA PAK3 MAGI3 CCND1 PI4KAP2 FGGY	2.47e-04	764	68	10	GO:0016301
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH10 DNAH17 DNAH8	2.70e-04	37	68	3	GO:0045505
GeneOntologyMolecularFunction	inositol-polyphosphate 5-phosphatase activity	INPP5B INPP5K	3.16e-04	8	68	2	GO:0004445
GeneOntologyMolecularFunction	inositol-1,4,5-trisphosphate 5-phosphatase activity	INPP5B INPP5K	3.16e-04	8	68	2	GO:0052658
GeneOntologyMolecularFunction	inositol tetrakisphosphate phosphatase activity	INPP5B INPP5K	4.05e-04	9	68	2	GO:0052743
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	INPP5B INPP5K	5.05e-04	10	68	2	GO:0004439
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase regulator activity	CCNE1 CCND1 CCNI	7.00e-04	51	68	3	GO:0016538
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate phosphatase activity	INPP5B INPP5K	7.38e-04	12	68	2	GO:0106019
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 5-phosphatase activity	INPP5B INPP5K	8.70e-04	13	68	2	GO:0034595
GeneOntologyMolecularFunction	inositol trisphosphate phosphatase activity	INPP5B INPP5K	1.01e-03	14	68	2	GO:0046030
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	CYFIP1 CYFIP2	1.01e-03	14	68	2	GO:0000340
GeneOntologyMolecularFunction	microtubule minus-end binding	HAUS4 MACF1	1.17e-03	15	68	2	GO:0051011
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CCNE1 MAK HIPK4 BRAF DGKA PAK3 MAGI3 CCND1 PI4KAP2 FGGY	1.22e-03	938	68	10	GO:0016772
GeneOntologyMolecularFunction	MAP kinase kinase activity	BRAF PAK3	1.69e-03	18	68	2	GO:0004708
GeneOntologyMolecularFunction	inositol phosphate phosphatase activity	INPP5B INPP5K	2.09e-03	20	68	2	GO:0052745
GeneOntologyMolecularFunction	proline-rich region binding	GHR CCND1	2.30e-03	21	68	2	GO:0070064
GeneOntologyMolecularFunction	RNA cap binding	CYFIP1 CYFIP2	2.30e-03	21	68	2	GO:0000339
GeneOntologyMolecularFunction	iron-sulfur cluster binding	RSAD1 TYW1B NFS1	2.39e-03	78	68	3	GO:0051536
GeneOntologyMolecularFunction	metal cluster binding	RSAD1 TYW1B NFS1	2.86e-03	83	68	3	GO:0051540
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	INPP5B INPP5K	3.80e-03	27	68	2	GO:0034593
GeneOntologyMolecularFunction	glutathione transferase activity	GSTK1 GSTO1	4.37e-03	29	68	2	GO:0004364
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	INPP5B INPP5K	4.67e-03	30	68	2	GO:0052866
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF27 DNAH10 VPS4B MACF1 CHD1 ATP13A2 ATP2A2 DNAH8	4.70e-03	775	68	8	GO:0017111
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP13A2 ATP2A2	6.68e-03	36	68	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP13A2 ATP2A2	6.68e-03	36	68	2	GO:0015662
GeneOntologyMolecularFunction	pyrophosphatase activity	KIF27 DNAH10 VPS4B MACF1 CHD1 ATP13A2 ATP2A2 DNAH8	7.49e-03	839	68	8	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KIF27 DNAH10 VPS4B MACF1 CHD1 ATP13A2 ATP2A2 DNAH8	7.54e-03	840	68	8	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KIF27 DNAH10 VPS4B MACF1 CHD1 ATP13A2 ATP2A2 DNAH8	7.54e-03	840	68	8	GO:0016818
GeneOntologyCellularComponent	microtubule associated complex	HAUS4 KIF27 DNAH10 DNAH17 DYNC1LI1 DNAH8	1.18e-05	161	66	6	GO:0005875
GeneOntologyCellularComponent	dynein complex	DNAH10 DNAH17 DYNC1LI1 DNAH8	2.55e-05	54	66	4	GO:0030286
GeneOntologyCellularComponent	axonemal dynein complex	DNAH10 DNAH17 DNAH8	6.58e-05	25	66	3	GO:0005858
GeneOntologyCellularComponent	microtubule organizing center	FNIP2 CEP350 CCNE1 HAUS4 MAK IFT172 VPS4B MAMLD1 DYNC1LI1 CCND1 NFS1	1.31e-04	919	66	11	GO:0005815
GeneOntologyCellularComponent	centrosome	FNIP2 CEP350 CCNE1 HAUS4 MAK VPS4B MAMLD1 DYNC1LI1 CCND1 NFS1	1.41e-04	770	66	10	GO:0005813
GeneOntologyCellularComponent	axoneme	MAK DNAH10 IFT172 DNAH17 DNAH8	4.97e-04	207	66	5	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	MAK DNAH10 IFT172 DNAH17 DNAH8	5.08e-04	208	66	5	GO:0097014
GeneOntologyCellularComponent	SCAR complex	CYFIP1 CYFIP2	6.35e-04	12	66	2	GO:0031209
GeneOntologyCellularComponent	outer dynein arm	DNAH17 DNAH8	6.35e-04	12	66	2	GO:0036157
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CCNE1 CCND1 CCNI	9.49e-04	61	66	3	GO:0000307
GeneOntologyCellularComponent	microtubule	HAUS4 KIF27 DNAH10 DNAH17 DYNC1LI1 MACF1 DNAH8	1.43e-03	533	66	7	GO:0005874
Domain	Cytoplasmic_FMR1-int	CYFIP1 CYFIP2	1.23e-05	2	66	2	IPR008081
Domain	FragX_IP	CYFIP1 CYFIP2	1.23e-05	2	66	2	PF05994
Domain	DUF1394	CYFIP1 CYFIP2	7.35e-05	4	66	2	PF07159
Domain	DUF1394	CYFIP1 CYFIP2	7.35e-05	4	66	2	IPR009828
Domain	CYCLINS	CCNE1 CCND1 CCNI	1.30e-04	28	66	3	PS00292
Domain	Cyclin_N	CCNE1 CCND1 CCNI	2.13e-04	33	66	3	IPR006671
Domain	Cyclin_N	CCNE1 CCND1 CCNI	2.13e-04	33	66	3	PF00134
Domain	CYCLIN	CCNE1 CCND1 CCNI	3.25e-04	38	66	3	SM00385
Domain	DHC_N1	DNAH10 DNAH8	3.40e-04	8	66	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH10 DNAH8	3.40e-04	8	66	2	IPR013594
Domain	-	CCNE1 CCND1 CCNI	3.79e-04	40	66	3	1.10.472.10
Domain	rSAM	RSAD1 TYW1B	4.36e-04	9	66	2	IPR007197
Domain	Radical_SAM	RSAD1 TYW1B	4.36e-04	9	66	2	PF04055
Domain	Cyclin-like	CCNE1 CCND1 CCNI	4.70e-04	43	66	3	IPR013763
Domain	IPPc	INPP5B INPP5K	5.43e-04	10	66	2	IPR000300
Domain	IPPc	INPP5B INPP5K	5.43e-04	10	66	2	SM00128
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH8	1.09e-03	14	66	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH8	1.09e-03	14	66	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH8	1.09e-03	14	66	2	IPR013602
Domain	DHC_N2	DNAH10 DNAH8	1.09e-03	14	66	2	PF08393
Domain	MT	DNAH10 DNAH8	1.09e-03	14	66	2	PF12777
Domain	AAA_8	DNAH10 DNAH8	1.09e-03	14	66	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH8	1.09e-03	14	66	2	IPR011704
Domain	AAA_5	DNAH10 DNAH8	1.09e-03	14	66	2	PF07728
Domain	DHC_fam	DNAH10 DNAH8	1.25e-03	15	66	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DNAH8	1.25e-03	15	66	2	IPR004273
Domain	Dynein_heavy	DNAH10 DNAH8	1.25e-03	15	66	2	PF03028
Domain	Cyclin_C	CCNE1 CCND1	1.62e-03	17	66	2	PF02984
Domain	Cyclin_C-dom	CCNE1 CCND1	1.62e-03	17	66	2	IPR004367
Domain	Cyclin_C	CCNE1 CCND1	1.62e-03	17	66	2	SM01332
Domain	Cation_ATPase_N	ATP13A2 ATP2A2	1.81e-03	18	66	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP13A2 ATP2A2	2.02e-03	19	66	2	IPR004014
Domain	P-loop_NTPase	SAMD9L KIF27 DNAH10 VPS4B DYNC1LI1 MAGI3 HELZ CHD1 DNAH8	2.85e-03	848	66	9	IPR027417
Domain	-	INPP5B INPP5K	3.78e-03	26	66	2	3.60.10.10
Domain	Exo_endo_phos	INPP5B INPP5K	3.78e-03	26	66	2	PF03372
Domain	Endo/exonuclease/phosphatase	INPP5B INPP5K	4.08e-03	27	66	2	IPR005135
Domain	-	ATP13A2 ATP2A2	5.70e-03	32	66	2	3.40.1110.10
Domain	-	ATP13A2 ATP2A2	5.70e-03	32	66	2	2.70.150.10
Domain	-	ALAS2 NFS1	6.79e-03	35	66	2	3.90.1150.10
Domain	ATPase_P-typ_cyto_domN	ATP13A2 ATP2A2	6.79e-03	35	66	2	IPR023299
Domain	ARM-type_fold	MROH9 USP34 IFT172 MROH2A HUWE1	6.92e-03	339	66	5	IPR016024
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH10 DNAH17 DNAH8	9.00e-05	27	46	3	M47755
Pathway	REACTOME_PTK6_REGULATES_CELL_CYCLE	CCNE1 CCND1	1.55e-04	6	46	2	M27733
Pathway	REACTOME_PTK6_REGULATES_CELL_CYCLE	CCNE1 CCND1	1.55e-04	6	46	2	MM15483
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	GHR CCNE1 BRAF CYP3A4 MUC16 CCND1	1.06e-06	170	68	6	19064572
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	FNIP2 ARID1B INPP5K DYNC1LI1 ALAS2 CCNI	1.79e-06	186	68	6	33637726
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DNAH17 DNAH8	2.56e-06	14	68	3	9373155
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP1 CYFIP2	3.77e-06	2	68	2	38128786
Pubmed	Lower serum CA125 level, negative vascular invasion, and wild BRAF were strongly associated with better 2-year disease-free survival in patients with stage III colorectal cancer who received adjuvant chemotherapy.	BRAF MUC16	3.77e-06	2	68	2	29562502
Pubmed	C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	CYFIP1 CYFIP2	3.77e-06	2	68	2	24357318
Pubmed	Familial breast cancers without mutations in BRCA1 or BRCA2 have low cyclin E and high cyclin D1 in contrast to cancers in BRCA mutation carriers.	CCNE1 CCND1	3.77e-06	2	68	2	18381935
Pubmed	BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome.	BRAF CCND1	3.77e-06	2	68	2	20485284
Pubmed	Expression of cyclin D1 and cyclin E significantly associates with human papillomavirus subtypes in Bowenoid papulosis.	CCNE1 CCND1	3.77e-06	2	68	2	23044415
Pubmed	GSK3β-dependent cyclin D1 and cyclin E1 degradation is indispensable for NVP-BEZ235 induced G0/G1 arrest in neuroblastoma cells.	CCNE1 CCND1	3.77e-06	2	68	2	28980866
Pubmed	Association of cyclin D1 and E1 expression with disease progression and biomarkers in patients with nonmuscle-invasive urothelial cell carcinoma of the bladder.	CCNE1 CCND1	3.77e-06	2	68	2	18047954
Pubmed	Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.	CYFIP1 CYFIP2	3.77e-06	2	68	2	34327661
Pubmed	Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.	CYFIP1 CYFIP2	3.77e-06	2	68	2	29752658
Pubmed	Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.	CYFIP1 CYFIP2	3.77e-06	2	68	2	35567753
Pubmed	Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.	CYFIP1 CYFIP2	3.77e-06	2	68	2	31324746
Pubmed	BRAF inhibitor therapy-associated melanocytic lesions lack the BRAF V600E mutation and show increased levels of cyclin D1 expression.	BRAF CCND1	3.77e-06	2	68	2	26997441
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	IFT172 DNAH17 MACF1	7.96e-06	20	68	3	21689717
Pubmed	MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1.	CCNE1 CCND1	1.13e-05	3	68	2	23383003
Pubmed	Immunohistochemical pattern of protein P21, cyclin D1 and cyclin E in endometrial hyperplasia.	CCNE1 CCND1	1.13e-05	3	68	2	19670700
Pubmed	Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.	CCNE1 CCND1	1.13e-05	3	68	2	19470724
Pubmed	Gene amplification of CCNE1, CCND1, and CDK6 in gastric cancers detected by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization.	CCNE1 CCND1	1.13e-05	3	68	2	27864121
Pubmed	Effects of nickel on cyclin expression, cell cycle progression and cell proliferation in human pulmonary cells.	CCNE1 CCND1	1.13e-05	3	68	2	19505905
Pubmed	Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm.	CCNE1 CCND1	1.13e-05	3	68	2	18651214
Pubmed	SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes.	CCNE1 CCND1	1.13e-05	3	68	2	29689621
Pubmed	Involvement of G1/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells.	CCNE1 CCND1	1.13e-05	3	68	2	12444551
Pubmed	[Cyclic RNA Molecule circ_0007766 Promotes the Proliferation of Lung Adenocarcinoma Cells by Up-regulating the Expression of Cyclin D1/CyclinE1/CDK4].	CCNE1 CCND1	1.13e-05	3	68	2	31109436
Pubmed	Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models.	CCNE1 CCND1	1.13e-05	3	68	2	26344002
Pubmed	[Characterization of genetic alterations in primary human melanomas carrying BRAF or NRAS mutation].	BRAF CCND1	1.13e-05	3	68	2	23795354
Pubmed	Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1.	CCNE1 CCND1	1.13e-05	3	68	2	27694442
Pubmed	The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node.	CCNE1 CCND1	1.13e-05	3	68	2	12096344
Pubmed	γ-Tocopherol inhibits human prostate cancer cell proliferation by up-regulation of transglutaminase 2 and down-regulation of cyclins.	CCNE1 CCND1	1.13e-05	3	68	2	22460364
Pubmed	[Prognostic importance of altered expression of cell cycle regulators in lung cancer].	CCNE1 CCND1	1.13e-05	3	68	2	12101670
Pubmed	Discrepant alterations in main candidate genes among multiple primary melanomas.	BRAF CCND1	1.13e-05	3	68	2	24885594
Pubmed	Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.	CCNE1 CCND1	1.13e-05	3	68	2	1833066
Pubmed	Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.	GHR CCNE1 CCND1	2.02e-05	27	68	3	31806625
Pubmed	Wnt pathway inhibitors are strongly down-regulated in pituitary tumors.	SFRP4 CCND1	2.25e-05	4	68	2	18079202
Pubmed	Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray.	CCNE1 CCND1	2.25e-05	4	68	2	12778072
Pubmed	Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells.	BRAF CCND1	2.25e-05	4	68	2	16924241
Pubmed	TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins.	CCNE1 CCND1	2.25e-05	4	68	2	11838966
Pubmed	Immunohistochemical expression of cyclin D1, cyclin E, p21/waf1 and p27/kip1 in inflammatory bowel disease: correlation with other cell-cycle-related proteins (Rb, p53, ki-67 and PCNA) and clinicopathological features.	CCNE1 CCND1	2.25e-05	4	68	2	15060836
Pubmed	Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.	CYFIP1 CYFIP2	2.25e-05	4	68	2	15294869
Pubmed	Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression.	CCNE1 CCND1	2.25e-05	4	68	2	23543735
Pubmed	Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.	CYFIP1 CYFIP2	2.25e-05	4	68	2	27605705
Pubmed	Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.	CYFIP1 CYFIP2	2.25e-05	4	68	2	20228810
Pubmed	Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: the critical role of hEag1 channels in G1 phase progression.	CCNE1 CCND1	2.25e-05	4	68	2	21315112
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	FNIP2 MROH9 ARID1B RSAD1 CYFIP1 CYP3A4 DNAH17 ZSCAN2 FGGY CYFIP2 LRRC23	2.73e-05	1242	68	11	30973865
Pubmed	Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells.	CCNE1 CCND1	3.75e-05	5	68	2	10908655
Pubmed	Cyclin D1 regulates p27(Kip1) stability in B cells.	CCNE1 CCND1	3.75e-05	5	68	2	20837141
Pubmed	The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma.	CCNE1 CCND1	3.75e-05	5	68	2	18301453
Pubmed	Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes.	CCNE1 CCND1	3.75e-05	5	68	2	16954383
Pubmed	Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer.	CCNE1 CCND1	3.75e-05	5	68	2	25744732
Pubmed	Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours.	SFRP4 CCND1	3.75e-05	5	68	2	11793365
Pubmed	Noxin promotes proliferation of breast cancer cells via P38-ATF2 signaling pathway.	CCNE1 CCND1	3.75e-05	5	68	2	28618963
Pubmed	Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation.	CCNE1 CCND1	3.75e-05	5	68	2	15327767
Pubmed	Effect of estrogen and tamoxifen on the expression pattern of AP-1 factors in MCF-7 cells: role of c-Jun, c-Fos, and Fra-1 in cell cycle regulation.	CCNE1 CCND1	3.75e-05	5	68	2	23625206
Pubmed	Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.	CEP350 BRAF	3.75e-05	5	68	2	25848750
Pubmed	Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis.	CCNE1 CCND1	3.75e-05	5	68	2	12601350
Pubmed	Macrophage inhibitory cytokine-1 stimulates proliferation of human umbilical vein endothelial cells by up-regulating cyclins D1 and E through the PI3K/Akt-, ERK-, and JNK-dependent AP-1 and E2F activation signaling pathways.	CCNE1 CCND1	3.75e-05	5	68	2	22484283
Pubmed	CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.	CCNE1 CCND1	3.75e-05	5	68	2	12529437
Pubmed	PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.	BRAF CCND1	3.75e-05	5	68	2	27977682
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	RSBN1 ARID1B CYFIP1 DYNC1LI1 MACF1 CHD1 GSTO1	3.85e-05	472	68	7	38943005
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP350 GPALPP1 SAMD9L DNAH17 MAGI3 MACF1 SLC45A4	5.07e-05	493	68	7	15368895
Pubmed	Inhibition of cyclin E-cyclin-dependent kinase 2 complex formation and activity is associated with cell cycle arrest and withdrawal in oligodendrocyte progenitor cells.	CCNE1 CCND1	5.62e-05	6	68	2	11160398
Pubmed	Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.	CCNE1 CCND1	5.62e-05	6	68	2	10500095
Pubmed	Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.	BRAF PAK3	5.62e-05	6	68	2	10205168
Pubmed	GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population.	GSTK1 GSTO1	5.62e-05	6	68	2	20472488
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	CYFIP1 CYFIP2	5.62e-05	6	68	2	11438699
Pubmed	Patterns of expression of cyclins A, B1, D, E and cdk 2 in preimplantation mouse embryos.	CCNE1 CCND1	5.62e-05	6	68	2	15214576
Pubmed	Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.	CCNE1 CCND1	5.62e-05	6	68	2	8978686
Pubmed	Rescue of cyclin D1 deficiency by knockin cyclin E.	CCNE1 CCND1	5.62e-05	6	68	2	10380928
Pubmed	Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.	CYFIP1 CYFIP2	5.62e-05	6	68	2	31853374
Pubmed	Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases.	CCNE1 CCND1	5.62e-05	6	68	2	9139732
Pubmed	Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.	CCNE1 CCND1	5.62e-05	6	68	2	10202152
Pubmed	A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.	CCNE1 CCND1	5.62e-05	6	68	2	10581175
Pubmed	Can the cardiomyocyte cell cycle be reprogrammed?	CCNE1 CCND1	5.62e-05	6	68	2	17362983
Pubmed	G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells.	CCNE1 CCND1	5.62e-05	6	68	2	28192421
Pubmed	Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27.	CCNE1 CCND1	5.62e-05	6	68	2	9311993
Pubmed	Inducible expression of cyclin D1 in T-47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation.	CCNE1 CCND1	5.62e-05	6	68	2	8867812
Pubmed	The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.	BRAF CCND1	5.62e-05	6	68	2	24019069
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	CCNE1 USP34 CYFIP1 BRAF PAK3 CHD1 NFS1 CCNI CYFIP2	6.84e-05	910	68	9	36736316
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	CYFIP1 MACF1 HELZ CCND1 HUWE1 CYFIP2	7.30e-05	358	68	6	32460013
Pubmed	Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice.	CYFIP1 CYFIP2	7.86e-05	7	68	2	30687000
Pubmed	Maid (GCIP) is involved in cell cycle control of hepatocytes.	CCNE1 CCND1	7.86e-05	7	68	2	17256742
Pubmed	The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells.	CCNE1 CCND1	7.86e-05	7	68	2	16431923
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH17 DNAH8	7.86e-05	7	68	2	31178125
Pubmed	p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.	CCNE1 CCND1	7.86e-05	7	68	2	8033213
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CEP350 USP34 ARID1B VPS4B DYNC1LI1 HELZ CHD1 HUWE1	9.09e-05	733	68	8	34672954
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	MAK IFT172 AIPL1 MACF1 CCND1	9.56e-05	233	68	5	32290105
Pubmed	Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.	CCNE1 CCND1	1.05e-04	8	68	2	15124020
Pubmed	Control of cell cycle gene expression in bone development and during c-Fos-induced osteosarcoma formation.	CCNE1 CCND1	1.05e-04	8	68	2	9664690
Pubmed	FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21Cip1 CDK inhibitor.	CCNE1 CCND1	1.05e-04	8	68	2	27425595
Pubmed	Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest.	CCNE1 CCND1	1.05e-04	8	68	2	11940657
Pubmed	RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.	CCNE1 CCND1	1.05e-04	8	68	2	19470470
Pubmed	Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.	CCNE1 CCND1	1.05e-04	8	68	2	20150892
Pubmed	Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells.	CCNE1 CCND1	1.34e-04	9	68	2	9632134
Pubmed	Characterization of murine gammaherpesvirus 68 v-cyclin interactions with cellular cdks.	CCNE1 CCND1	1.34e-04	9	68	2	16102793
Pubmed	Cell cycle during neuronal migration and neocortical lamination.	CCNE1 CCND1	1.34e-04	9	68	2	33448039
Pubmed	Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.	CUL2 ARID1B	1.34e-04	9	68	2	20086098
Pubmed	Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.	CYFIP1 CYFIP2	1.34e-04	9	68	2	38981622
Pubmed	Cell cycle regulation in mouse heart during embryonic and postnatal stages.	CCNE1 CCND1	1.34e-04	9	68	2	22957921
GeneFamily	Dyneins, axonemal	DNAH10 DNAH17 DNAH8	1.09e-05	17	47	3	536
GeneFamily	Cyclins	CCNE1 CCND1 CCNI	5.15e-05	28	47	3	473
GeneFamily	Maestro heat like repeat containing	MROH9 MROH2A	3.58e-04	11	47	2	636
GeneFamily	Glutathione S-transferases	GSTK1 GSTO1	1.91e-03	25	47	2	567
GeneFamily	Phosphoinositide phosphatases	INPP5B INPP5K	3.12e-03	32	47	2	1079
Coexpression	GSE22601_DOUBLE_NEGATIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_DN	CUL2 MINDY3 SAMD9L INPP5B ATP2A2 DNAH8	1.35e-05	200	68	6	M6243
Coexpression	SAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN	GSTK1 CYP3A4 GSTO1	1.84e-05	20	68	3	MM1104
Coexpression	GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_4H_DN	BRAF AIPL1 CCND1 CCNI CDH8	2.25e-05	130	68	5	M6087
Coexpression	BONCI_TARGETS_OF_MIR15A_AND_MIR16_1	GHR CCNE1 MACF1 CCND1	9.75e-05	92	68	4	M11682
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	CEP350 USP34 SAMD9L GSTK1 DHRS7 DGKA MACF1 HELZ CHD1 HUWE1 CCNI SP110 CYFIP2	1.04e-04	1492	68	13	M40023
Coexpression	KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN	CUL2 CYFIP1 DGKA ALAS2 GSTO1	1.24e-04	186	68	5	M1993
Coexpression	BAKER_HEMATOPOESIS_STAT5_TARGETS	CCNE1 CCND1	1.38e-04	7	68	2	M1165
Coexpression	BAKER_HEMATOPOESIS_STAT5_TARGETS	CCNE1 CCND1	1.38e-04	7	68	2	MM1110
Coexpression	GSE21927_SPLEEN_C57BL6_VS_EL4_TUMOR_BALBC_MONOCYTES_UP	CEP350 USP34 GSTK1 MACF1 CYFIP2	1.70e-04	199	68	5	M7596
Coexpression	GSE2770_IL4_ACT_VS_ACT_CD4_TCELL_48H_UP	FNIP2 CUL2 MINDY3 ATP2A2 CYFIP2	1.70e-04	199	68	5	M6040
Coexpression	GSE3039_CD4_TCELL_VS_B2_BCELL_UP	GHR DNAH17 PPM1E SP110 DNAH8	1.74e-04	200	68	5	M6462
Coexpression	GSE411_100MIN_VS_400MIN_IL6_STIM_MACROPHAGE_UP	CEP350 CYFIP1 UBP1 DHRS7 LRRC23	1.74e-04	200	68	5	M5997
Coexpression	GSE43863_NAIVE_VS_MEMORY_TFH_CD4_TCELL_D150_LCMV_UP	MAK IFT172 DGKA ATP13A2 CYFIP2	1.74e-04	200	68	5	M9737
Coexpression	GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_45MIN_DN	RSAD1 SAMD9L INPP5B SP110 CYFIP2	1.74e-04	200	68	5	M6630
Coexpression	HALLMARK_XENOBIOTIC_METABOLISM	DHRS7 NFS1 GSTO1 ATP2A2 CYFIP2	1.74e-04	200	68	5	M5934
Coexpression	GSE5679_PPARG_LIGAND_ROSIGLITAZONE_VS_RARA_AGONIST_AM580_TREATED_DC_DN	SAMD9L INPP5B DGKA HUWE1 SLC45A4	1.74e-04	200	68	5	M6563
Coexpression	GSE5455_EX_VIVO_VS_POST_24H_INCUBATION_MONOCYTES_FROM_TUMOR_BEARING_MOUSE_DN	SAMD9L INPP5B DGKA HUWE1 SLC45A4	1.74e-04	200	68	5	M6580
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_500_k-means-cluster#4	PPM1E MAMLD1 PAK3 CDH8 CYFIP2	7.82e-05	137	68	5	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	CEP350 PPM1E MAMLD1 PAK3 CHD1 CDH8 CYFIP2	8.51e-05	328	68	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	PPM1E MAMLD1 PAK3 CHD1 CDH8 CYFIP2	9.68e-05	231	68	6	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500_k-means-cluster#5	PPM1E MAMLD1 PAK3 CHD1 CDH8 CYFIP2	9.92e-05	232	68	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500_K5
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CEP350 USP34 ARID1B SAMD9L MACF1 HELZ CHD1 SP110	7.79e-10	200	68	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 ARID1B BRAF MACF1 CHD1 HUWE1	4.34e-07	188	68	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	USP34 ARID1B DGKA MACF1 HUWE1	8.46e-06	181	68	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MROH2A MACF1 CCND1 CCNI	1.13e-05	192	68	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	ARID1B SAMD9L BRAF CHD1 SP110	1.27e-05	197	68	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARID1B SAMD9L BRAF CHD1 SP110	1.31e-05	198	68	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARID1B SAMD9L BRAF CHD1 SP110	1.31e-05	198	68	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	ARID1B BRAF MACF1 CHD1 SP110	1.37e-05	200	68	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FNIP2 HIPK4 ATP2A2 LILRA4	6.62e-05	142	68	4	d60d2a5d0876a552bc161fc4e2dfe180f88f03a5
ToppCell	severe_influenza-CD8+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	TCAF2 KIF27 DGKA ZNF891	1.08e-04	161	68	4	82196139cdbbd70a36957a87bc9ac6d02575da3f
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	USP34 BRAF DGKA MACF1	1.10e-04	162	68	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, Lineage and Cell Type	TIMD4 DNAH10 IFT172 LILRA4	1.18e-04	165	68	4	8728f927502e56f2768b4224e9111939d3d7815a
ToppCell	lung-Ciliated_Epithelia\|lung / shred on tissue and cell subclass	MAK KIF27 MUC16 LRRC23	1.24e-04	167	68	4	26cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell	CV-Mild-6\|CV / Virus stimulation, Condition and Cluster	TIMD4 DNAH10 MAGI3 FRMPD3	1.24e-04	167	68	4	cf2ed0b6d17a16f9a2318879ce8856d5983ad3cf
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GHR MAK SAMD9L DYNC1LI1	1.27e-04	168	68	4	3fb79aaa858057c82645a90bd139fc4f096323c7
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAMLD1 AIPL1 CCND1 DNAH8	1.27e-04	168	68	4	55c9de7b3a1d6cf7b02b020ff92ab4ede8d195cc
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	GHR MAK SAMD9L DYNC1LI1	1.30e-04	169	68	4	0589f39d8e9468e42d25d30ff70bb7cb8b921628
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYFIP1 SFRP4 TIMD4 ATP13A2	1.30e-04	169	68	4	44d841fd997a6f26104f16cd00223ecce8352f43
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	DNAH10 HELZ ZNF891 LILRA4	1.45e-04	174	68	4	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	CV-Mild-6\|Mild / Virus stimulation, Condition and Cluster	BRAF DNAH10 MAGI3 FRMPD3	1.48e-04	175	68	4	c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	DNAH10 CCND1 ZNF891 LILRA4	1.52e-04	176	68	4	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	B_cells-pDCs\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FNIP2 KCTD19 ATP13A2 LILRA4	1.52e-04	176	68	4	ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DGKA MUC16 MACF1 SLC45A4	1.62e-04	179	68	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 SAMD9L MACF1 CHD1	1.72e-04	182	68	4	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Deuterosomal\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DNAH10 DNAH17 PPM1E LRRC23	1.72e-04	182	68	4	000eca5baa6eb2335a1e6d76a13fff5382b0e150
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK KIF27 DNAH10 LRRC23	1.80e-04	184	68	4	264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 SAMD9L MACF1 CHD1	1.80e-04	184	68	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK KIF27 DNAH10 LRRC23	1.80e-04	184	68	4	d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK KIF27 DNAH10 LRRC23	1.80e-04	184	68	4	22010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 SAMD9L MACF1 CHD1	1.83e-04	185	68	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	droplet-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 SAMD9L DGKA MACF1	1.87e-04	186	68	4	26f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK KIF27 DNAH10 LRRC23	1.91e-04	187	68	4	04dba2ed09ee4180830bdf0191921696697ea234
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-Tregs\|bone_marrow / Manually curated celltypes from each tissue	RSBN1 GSTK1 DGKA DNAH8	1.91e-04	187	68	4	bda716a64262325e6e68b281caf131f1840fd298
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TCAF2 UBP1 MAGI3 FGGY	1.91e-04	187	68	4	4527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCell	facs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAK KIF27 DNAH10 LRRC23	1.91e-04	187	68	4	805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCell	PND10-Epithelial-Epithelial_Airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAK KIF27 GSTO1 LRRC23	1.99e-04	189	68	4	407d8a59969d83f014600aae1a55092283a13970
ToppCell	Epithelial-D_(Ciliated)\|World / shred on cell class and cell subclass (v4)	MAK KIF27 DNAH10 LRRC23	1.99e-04	189	68	4	0bf560b595c7a8450a46bc821b742b67965bd9f9
ToppCell	PND01-Epithelial-Epithelial_Airway\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAK KIF27 DNAH10 LRRC23	1.99e-04	189	68	4	38cde34295566a4ecaf7d0a81c5a192cf17d0459
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAK KIF27 DNAH10 LRRC23	2.03e-04	190	68	4	9ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAK KIF27 DNAH10 LRRC23	2.03e-04	190	68	4	3ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCell	E18.5-Epithelial-Epithelial_Airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAK KIF27 GSTO1 LRRC23	2.03e-04	190	68	4	5c012935ea5e35a2d0d08ea7dc04ffbe3c2a10ac
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAK KIF27 DNAH10 LRRC23	2.07e-04	191	68	4	e8d56e9f43943e9cc4dce83f2c234f19c2dd487d
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAK KIF27 DNAH10 LRRC23	2.07e-04	191	68	4	52e8d7dfaf1ebb6df8bf3a1f4546af59faa67657
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAK KIF27 DNAH10 LRRC23	2.07e-04	191	68	4	96483adb97c81208aa513782550acd8a08b63866
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	BRAF DGKA MACF1 CHD1	2.11e-04	192	68	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Ciliated-cil-3\|World / Class top	MAK DNAH10 IFT172 LRRC23	2.11e-04	192	68	4	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	SAMD9L BRAF CHD1 SP110	2.16e-04	193	68	4	7256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 SAMD9L MACF1 CHD1	2.20e-04	194	68	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 HUWE1 ATP2A2 CYFIP2	2.24e-04	195	68	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 HUWE1 ATP2A2 CYFIP2	2.24e-04	195	68	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	(05)_Ciliated\|World / shred by cell type and Timepoint	MAK DNAH10 IFT172 LRRC23	2.33e-04	197	68	4	fee3cd16af8eea697cd64e8f64af505aaa2ac4b0
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 IFT172 MUC16 LRRC23	2.33e-04	197	68	4	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 IFT172 MUC16 LRRC23	2.33e-04	197	68	4	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 IFT172 MUC16 LRRC23	2.33e-04	197	68	4	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 IFT172 MUC16 LRRC23	2.33e-04	197	68	4	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	(5)_Dendritic_cell-(54)_pDC\|(5)_Dendritic_cell / shred on Cell_type and subtype	DHRS7 ATP13A2 CYFIP2 LILRA4	2.38e-04	198	68	4	fc6c6b60dddd7f2f997af0f87fae33f1c23f34a8
ToppCell	CV-Mild-1\|CV / Virus stimulation, Condition and Cluster	SAMD9L TIMD4 GSTK1 SP110	2.38e-04	198	68	4	4b078714c49e7befb7b113d72485e712236d35fa
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 ARID1B BRAF MACF1	2.42e-04	199	68	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Goblet_3\|World / shred by cell class for nasal brushing	GSTK1 DHRS7 MUC16 GSTO1	2.42e-04	199	68	4	4229a17a3a6d8855655acc0a1c8704166f8e74c0
ToppCell	Sepsis-Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, condition lineage and cell class	TIMD4 DNAH10 IFT172 LILRA4	2.42e-04	199	68	4	a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCell	mild-CD4+_Tcm\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RSBN1 GSTK1 DGKA MACF1	2.42e-04	199	68	4	06c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	SAMD9L TIMD4 DGKA MACF1	2.42e-04	199	68	4	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	Bronchial_Biopsy-Epithelial\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	IFT172 MUC16 CCND1 ATP2A2	2.42e-04	199	68	4	ef5d8917c8d011184830a0b8197afc6266707b37
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SAMD9L MACF1 HUWE1 CYFIP2	2.47e-04	200	68	4	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	metastatic_Brain-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	FNIP2 CYFIP1 GSTO1 ATP2A2	2.47e-04	200	68	4	bfb54a8ce44caf01083c6567b236395c6ee1d47a
Computational	Genes in the cancer module 119.	USP34 KIF27 DGKA SP110 CYFIP2	1.98e-04	143	41	5	MODULE_119
Disease	ovarian carcinoma (biomarker_via_orthology)	CCNE1 MUC16	5.23e-06	2	68	2	DOID:4001 (biomarker_via_orthology)
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP1 CYFIP2	1.57e-05	3	68	2	DOID:0060393 (implicated_via_orthology)
Disease	liver cancer (biomarker_via_orthology)	CCNE1 CCND1	5.21e-05	5	68	2	DOID:3571 (biomarker_via_orthology)
Disease	Malignant Neoplasms	CCNE1 BRAF CCND1 GSTO1	2.22e-04	128	68	4	C0006826
Disease	leukemia	BRAF CCND1 GSTO1	2.82e-04	55	68	3	C0023418
Disease	Chronic Lymphocytic Leukemia	BRAF CCND1 LILRA4	2.82e-04	55	68	3	C0023434
Disease	rheumatoid arthritis, COVID-19	RSBN1 INPP5B MAGI3	4.41e-04	64	68	3	EFO_0000685, MONDO_0100096
Disease	lymphocyte count	FNIP2 GPALPP1 RSBN1 KIF27 TIMD4 DNAH10 CYP3A4 DNAH17 HELZ NFS1 SLC45A4	4.89e-04	1464	68	11	EFO_0004587
Disease	Prostatic Neoplasms	GHR BRAF GSTK1 CYP3A4 CHD1 CCND1 GSTO1	5.38e-04	616	68	7	C0033578
Disease	Malignant neoplasm of prostate	GHR BRAF GSTK1 CYP3A4 CHD1 CCND1 GSTO1	5.38e-04	616	68	7	C0376358
Disease	5-oxoproline measurement	CCNI DNAH8	6.15e-04	16	68	2	EFO_0010988
Disease	Malignant neoplasm of breast	CCNE1 ARID1B BRAF CYP3A4 INPP5K PPM1E MACF1 CCND1 SP110	7.77e-04	1074	68	9	C0006142
Disease	sexual dimorphism measurement	CCNE1 SFRP4 DNAH10 KCTD19 INPP5B MACF1 ZSCAN2 NFS1 ATP13A2	9.56e-04	1106	68	9	EFO_0021796
Disease	Liver carcinoma	GHR CCNE1 ARID1B TIMD4 BRAF CCND1	1.11e-03	507	68	6	C2239176
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	TIMD4 DNAH10 TYW1B MACF1	1.19e-03	200	68	4	EFO_0004611, EFO_0020945
Disease	Colorectal cancer	BRAF CCND1	1.77e-03	27	68	2	cv:C0346629
Disease	COLORECTAL CANCER	BRAF CCND1	1.77e-03	27	68	2	114500
Disease	Neoplasm of the large intestine	BRAF CCND1	1.77e-03	27	68	2	cv:C0009404
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	TIMD4 DNAH10 TYW1B MACF1	1.80e-03	224	68	4	EFO_0004530, EFO_0008317
Disease	Retinitis Pigmentosa	MAK IFT172 AIPL1	1.81e-03	104	68	3	C0035334
Disease	Neoplasm of uncertain or unknown behavior of ovary	CCNE1 BRAF	2.04e-03	29	68	2	C0496920
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	TIMD4 DNAH10 TYW1B	2.12e-03	110	68	3	EFO_0008317, EFO_0008596, EFO_0010351
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	TIMD4 DNAH10 TYW1B	2.12e-03	110	68	3	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	TIMD4 DNAH10 TYW1B	2.12e-03	110	68	3	EFO_0004574, EFO_0008317, EFO_0008596
Disease	triglyceride measurement, intermediate density lipoprotein measurement	TIMD4 DNAH10 TYW1B	2.17e-03	111	68	3	EFO_0004530, EFO_0008595
Disease	Ovarian Carcinoma	CCNE1 BRAF	2.18e-03	30	68	2	C0029925

Protein segments in the cluster

Peptide	Gene	Start	Entry
SILWMAPEVIRMQDK	BRAF	616	P15056
MFKLEVWEILLTSMR	AIPL1	66	Q9NZN9
QPKMRAILLDWLMEV	CCNE1	141	P24864
MVSLEMEKLIPDWLS	CCNI	206	Q14094
IVTPEAWRVMMSLKS	ARID1B	1701	Q8NFD5
EVLPSMRKIVATWML	CCND1	51	P24385
LVMFLSVLVDWMIPD	ANO2	916	Q9NQ90
RLMLISMANDLKEVW	DHRS7	271	Q9Y394
GSWEMIKMDPDLSLT	CHD1	1271	O14646
PMQKLISLVREWDMV	KCTD19	631	Q17RG1
EMSMPWILTDHILET	CYFIP1	641	Q7L576
EMTTVMNKDPEILSW	MUC16	6776	Q8WXI7
PKVDIWSLGIMAIEM	PAK3	456	O75914
MSELTKELMELVWGT	MINDY3	1	Q9H8M7
ESENKVKLSIPSMMW	LILRA4	76	P59901
MMRDETLEPLPKNWE	MAGI3	286	Q5TCQ9
MSPLWEMVQDGIDLK	NFS1	436	Q9Y697
LWMAAMKEDPTVSAL	GSTO1	201	P78417
DLKSMVELIKRMLTW	HIPK4	316	Q8NE63
VMLVVDMSKPWTALD	DYNC1LI1	146	Q9Y6G9
MALIPDLAMETWLLL	CYP3A4	1	P08684
EEWLPTPLTEDMMKE	LRRC23	41	Q53EV4
MLSEELKWASRPESM	KIF27	1256	Q86VH2
VEIWLLDLLKMQMSS	DNAH8	1651	Q96JB1
DLLDISNLPMWKPML	DNAH8	4036	Q96JB1
WDVSELRPILQEMMK	DGKA	151	P23743
MSMPWILTDHILETK	CYFIP2	666	Q96F07
LQILKEMLVWMSKDS	MROH9	121	Q5TGP6
METLIEKWMNSLSPE	HELZ	236	P42694
AWLMLVEKMVNPTTV	HUWE1	1201	Q7Z6Z7
PQMMEDFVEKLLLAW	ALAS2	526	P22557
ESQLRPWLMEKELMM	MACF1	4586	Q9UPN3
ETLEMTPETEAMWKT	IFT172	616	Q9UG01
LMMEKKSVQSSLPEW	PPM1E	606	Q8WY54
WLMVLKISLPVILMD	ATP2A2	966	P16615
DPMDLKMVESTGWVL	ATP13A2	571	Q9NQ11
MDLLMEKSWPVMLVG	DNAH17	2441	Q9UFH2
ETKWKMMDPILTTSV	GHR	201	P10912
MSVEMQAPKLLWLKE	FGGY	141	Q96C11
IMDAKPLVLLMEWPE	FRMPD3	461	Q5JV73
AEPVWLTMMSGTLEK	FNIP2	396	Q9P278
IVLMPEDLWTVENDM	INPP5K	331	Q9BT40
PEMLEKASRELWMRV	GSTK1	111	Q9Y2Q3
IVRESWMTELPPEMK	GPALPP1	186	Q8IXQ4
ELALDMWRKLMVEPL	CUL2	141	Q13617
KDLMESTWMQPERLS	CEP350	726	Q5VT06
EAIQLMTEMLNWDPK	MAK	256	P20794
MDDWKSRLVIKSMLP	MAMLD1	1	Q13495
SQLDSPMEIPKELWM	INPP5B	821	P32019
MPERLAEMLLDLWTP	CDH8	1	P55286
DLLELMPLSEDFVWM	HAUS4	146	Q9H6D7
KVLMVEEPSMNLEWL	MT-CO1	481	P00395
WMEVTEQVLPALMKK	DNAH10	626	Q8IVF4
APSMADMWELEIALL	MROH2A	611	A6NES4
IQTLEPDNWMKEVML	RSAD1	321	Q9HA92
DMLEESPFLKMTLPW	RSBN1	496	Q5VWQ0
LKDPEPVLRLWDEMM	TCAF2	681	A6NFQ2
MSKQVSLPEMIKDWT	SAMD9L	1	Q8IVG5
AMWLDLVKERLITEM	SP110	616	Q9HB58
GWEPDIKLTDEMVMI	PI4KAP2	476	A4QPH2
ETTVRLLWLSMLKMP	SLC45A4	491	Q5BKX6
AIEMTWMDVPGDKLL	VPS4B	391	O75351
EQMLTMLPKEIQAWL	ZSCAN2	96	Q7Z7L9
LPEDVKWIDITPDMM	SFRP4	146	Q6FHJ7
ALWPEDDLKVVRIMM	TMEM225	56	Q6GV28
MAWVLKMDEVIESGL	UBP1	1	Q9NZI7
NMADLMWSTVKEPLD	USP34	291	Q70CQ2
MSKEPLILWLMIEFW	TIMD4	1	Q96H15
WEEPSNAVKMIKLTM	ZNF891	131	A8MT65
WLWKMDQPEMILKEA	TYW1B	371	Q6NUM6