Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentdendrite

GRIP1 KCNQ3 MCRS1 PLEC SLC30A1 GPR37

8.15e-04858286GO:0030425
GeneOntologyCellularComponentdendritic tree

GRIP1 KCNQ3 MCRS1 PLEC SLC30A1 GPR37

8.25e-04860286GO:0097447
GeneOntologyCellularComponentsomatodendritic compartment

GRIP1 KCNQ3 MCRS1 SERPINI1 PLEC SLC30A1 GPR37

9.44e-041228287GO:0036477
GeneOntologyCellularComponentbasal plasma membrane

PLEC SLC30A1 KCNQ4 PKD1

1.20e-03354284GO:0009925
GeneOntologyCellularComponentbasal part of cell

PLEC SLC30A1 KCNQ4 PKD1

1.53e-03378284GO:0045178
DomainK_chnl_volt-dep_KCNQ

KCNQ3 KCNQ4

2.01e-055272IPR003937
DomainKCNQ_channel

KCNQ3 KCNQ4

2.01e-055272PF03520
DomainK_chnl_volt-dep_KCNQ_C

KCNQ3 KCNQ4

2.01e-055272IPR013821
DomainVG_K_chnl

KCNQ3 KCNQ4

1.03e-0333272IPR028325
DomainC_TYPE_LECTIN_1

REG4 PKD1

5.93e-0380272PS00615
DomainLectin_C

REG4 PKD1

6.52e-0384272PF00059
DomainCLECT

REG4 PKD1

6.52e-0384272SM00034
DomainC_TYPE_LECTIN_2

REG4 PKD1

6.67e-0385272PS50041
DomainARM-like

RIPOR1 AP4B1 MROH2A

6.76e-03270273IPR011989
DomainC-type_lectin-like

REG4 PKD1

6.83e-0386272IPR001304
Domain-

REG4 PKD1

8.61e-03972723.10.100.10
DomainC-type_lectin-like/link

REG4 PKD1

8.96e-0399272IPR016186
DomainCTDL_fold

REG4 PKD1

1.04e-02107272IPR016187
DomainIon_trans_dom

KCNQ3 KCNQ4

1.17e-02114272IPR005821
DomainIon_trans

KCNQ3 KCNQ4

1.17e-02114272PF00520
DomainARM-type_fold

RIPOR1 AP4B1 MROH2A

1.26e-02339273IPR016024
Pubmed

REG4 promotes peritoneal metastasis of gastric cancer through GPR37.

REG4 GPR37

6.25e-07228227036049
Pubmed

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.

KCNQ3 KCNQ4

6.25e-07228210025409
Pubmed

Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries.

KCNQ3 KCNQ4

1.87e-06328226969140
Pubmed

Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.

KCNQ3 KCNQ4

1.87e-06328218786918
Pubmed

Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.

KCNQ3 KCNQ4

3.75e-06428210713961
Pubmed

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.

KCNQ3 KCNQ4

3.75e-06428212524525
Pubmed

The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.

KCNQ3 KCNQ4

6.24e-06528220132415
Pubmed

Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase.

KCNQ3 KCNQ4

6.24e-06528215304482
Pubmed

Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.

KCNQ3 KCNQ4

9.36e-06628221730298
Pubmed

The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death.

GRIP1 GPR37

9.36e-06628224749734
Pubmed

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.

SERPINI1 HMCN1

9.49e-051828223534349
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

PLEC PRAMEF22 PKD1 RPL19

1.41e-0433328432665550
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

ORC1 THAP3 AP4B1 REG4 HMCN1 PRAMEF22

1.44e-04103128616710414
Pubmed

NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.

MYO18A PLEC

1.85e-042528230309841
Pubmed

Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.

KLHL2 MITF

2.50e-042928212652657
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

KCNQ3 RIPOR1 SLC30A1 GPR37

2.97e-0440528438187761
Pubmed

Ion channel expression in the developing enteric nervous system.

KCNQ3 KCNQ4

4.09e-043728225798587
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

MYO18A PLEC PKD1

4.54e-0418728326460568
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNQ3 KCNQ4

4.78e-044028216382104
Pubmed

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

MYO18A PLEC

6.06e-044528222114352
Cytoband8q24

KCNQ3 PLEC

1.34e-04282828q24
GeneFamilyPotassium voltage-gated channels

KCNQ3 KCNQ4

1.39e-0340252274
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

REG4 PKD1

1.46e-03412521298
GeneFamilyPDZ domain containing

MYO18A GRIP1

1.86e-021522521220
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

MYO18A KLHL2 SERPINI1 PLEC SLC30A1 GPR37 PRAMEF22 FRMD5

1.61e-051124288MM1070
ToppCellClub_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

MYO18A SERPINI1 HMCN1

5.77e-051202837f85208f0455f3e634f8e7e81beea60b4ef1d2a5
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_smooth_muscle-like|E16.5-samps / Age Group, Lineage, Cell class and subclass

SERPINI1 REG4 KCNQ4

7.66e-051322839633653dba1edee47d915212fb6e68426da49de5
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIP1 HMCN1 MROH2A

1.35e-04160283c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIP1 HMCN1 MROH2A

1.35e-0416028325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SERPINI1 AP4B1 NEMP2

1.38e-041612839703b7e67d9fadb6129cad166bd01be915042e44
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4|Liver / Manually curated celltypes from each tissue

REG4 FRMD5 RPL19

1.54e-04167283ab6273ae5d76a3f9a05c58320e3dee80f9b99e47
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPOR1 PLEC HMCN1

1.54e-04167283b93103a868fba63a8910bffb690a6242b9252833
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPOR1 PLEC HMCN1

1.54e-0416728326cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPOR1 PLEC HMCN1

1.54e-04167283fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPOR1 PLEC HMCN1

1.54e-04167283f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCelldroplet-Fat-Gat-18m-Lymphocytic-B_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINI1 RPL19 PRR5

1.62e-041702835185187ecf26b4c9eaa0c01ad52697ab8d075cc7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AP4B1 SLC30A1 FRMD5

1.71e-04173283506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 KCNQ4 RPL19

1.79e-04176283c6484334187f64cd00cd35e77d8ae436556b4260
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4|TCGA-Lung / Sample_Type by Project: Shred V9

KCNQ3 SLC30A1 FRMD5

1.79e-041762830923b01137d6f9956ca815b41102c81e82624065
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCNQ3 KCNQ4 FRMD5

1.82e-041772837ebdcedfe02da6d05bba3d625d8bd4c4ea96e4ad
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

KCNQ3 KLHL2 FRMD5

2.04e-04184283d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

GRIP1 KCNQ3 FRMD5

2.08e-04185283cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GRIP1 KCNQ3 FRMD5

2.11e-04186283b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIP1 FRMD5 MITF

2.11e-041862836379609b7ace80683f5754b16aa77f11b43766ae
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

GRIP1 FRMD5 MITF

2.18e-041882836d249fe92d51a19da19ec14bb2262d394255d577
ToppCellNeuronal_cells-Schwann_cells|World / Lineage and Cell class

KLHL2 GPR37 FRMD5

2.21e-04189283371cdc92549269e45c23c5a5b3cae9c5d35ee217
ToppCellNeuronal_cells|World / Lineage and Cell class

KLHL2 GPR37 FRMD5

2.21e-041892833948775a0ebd4b32c1623d5487f5581e6e2934d7
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GRIP1 KCNQ3 FRMD5

2.21e-0418928328b502611829e4a24caff2562545c7db97686099
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIP1 FRMD5 MITF

2.25e-041902838c9c230a509afaeee50644153974a5642b01a2b8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIP1 FRMD5 MITF

2.28e-04191283de54dab85db70f847de75b3b6d7667a0e13b9bfb
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

GRIP1 FRMD5 MITF

2.28e-041912835d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell(2)_Fibroblasts-(21)_Fibro-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

GRIP1 PLEC MITF

2.28e-041912835ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIP1 FRMD5 MITF

2.32e-04192283dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIP1 FRMD5 MITF

2.35e-0419328353bcd50892c379b2a571751f6eb1062436339fe7
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIP1 FRMD5 MITF

2.35e-041932835581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

GRIP1 FRMD5 MITF

2.39e-0419428389812fb164065041357bb37a3c2d87028ec3de4e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

GRIP1 FRMD5 MITF

2.39e-04194283c3535f7cc0076653c72db582047cff053c322397
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR1 HMCN1 SLC30A1

2.39e-04194283f159ef8541d75a4e98468947f231bb463bec922c
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GRIP1 ORC1 FRMD5

2.50e-0419728349689a03ab31e53386dbe15c77c09ca3a14ebf4e
ToppCellnormal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

REG4 RPL19 PRR5

2.50e-04197283b5b333e98753946793ceb45e2d85c25ef53568b4
ToppCellnormal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|normal / PBMC cell types (v2) per disease, treatment status, and sex

REG4 RPL19 PRR5

2.50e-041972834cec48e202f4583c9328d4b722c49ed3471ec173
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIP1 KCNQ3 SERPINI1

2.54e-041982830ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIP1 FRMD5 MITF

2.61e-0420028345ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
Drugezogabine

KCNQ3 KCNQ4

4.37e-063282ctd:C101866
DrugQuinazolinones

KCNQ3 KCNQ4

1.46e-055282ctd:D052999
DrugN-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide

KCNQ3 KCNQ4

2.18e-056282ctd:C476437
Drugisovaleramide

KCNQ3 KCNQ4

4.07e-058282CID000010930
Drugeslicarbazepine acetate

KCNQ3 KCNQ4

4.07e-058282CID000179344
Drugvalrocemide

KCNQ3 KCNQ4

4.07e-058282CID006918293
Diseaselong QT syndrome (implicated_via_orthology)

KCNQ3 KCNQ4

3.61e-0510272DOID:2843 (implicated_via_orthology)
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

KCNQ3 KCNQ4

6.25e-0513272DOID:0112202 (implicated_via_orthology)
Diseaseheart conduction disease (implicated_via_orthology)

KCNQ3 KCNQ4

3.93e-0432272DOID:10273 (implicated_via_orthology)
Diseaseleft ventricular ejection fraction measurement

PLEC MITF

6.16e-0440272EFO_0008373
DiseaseCongenital small ears

GRIP1 ORC1

6.47e-0441272C0152423

Protein segments in the cluster

PeptideGeneStartEntry
VRGLALRSMCSLRMP

AP4B1

101

Q9Y6B7
FLQILRMLRMDRRGG

KCNQ3

231

O43525
SALRSMRFLQILRMV

KCNQ4

201

P56696
SLDNRRTLMLLAQMS

IFNA1;

31

P01562
LRGSRLLDAMRMYRQ

MYO18A

1096

Q92614
RSRSLLMWMLRLLSL

NEMP2

266

A6NFY4
NSVRILSGGRMLRLM

HMCN1

2431

Q96RW7
RIMMNRVSSRLGLTR

ORC1

661

Q13415
MLSRLMSGSSRSLER

FRMD5

1

Q7Z6J6
MRAPGALLARMSRLL

GPR37

1

O15354
SLGSRRTLMLLAQMR

IFNA2

31

P01563
RTLMLLAQMRRISLF

IFNA2

36

P01563
LAVLRGRMVRYLMRS

MCRS1

346

Q96EZ8
RRVSLRNMTLLATIM

GRIP1

916

Q9Y3R0
TSALMRILMRSRVLN

PKD1

2756

P98161
MASRSMRLLLLLSCL

REG4

1

Q9BYZ8
RNRRTGTILFMGRVM

SERPINI1

381

Q99574
QRTRMASMNVLSSLL

MROH2A

1011

A6NES4
GDRIMLMLSFSRLLL

TAS2R40

56

P59535
MRTLRRLKFMSSPSL

PRR5

1

P85299
MRMSLQAPRRLLELA

PRAMEF22

1

A3QJZ6
MSMLRLQKRLASSVL

RPL19

1

P84098
SSMTSRILLRQQLMR

MITF

51

O75030
LQVMRAMASLRARGL

PLEC

46

Q15149
MRTRLERSIQMLTLL

TMED1

161

Q13445
LVMRRMSSRLRACKG

THAP3

211

Q8WTV1
RNRGRLLCMLALTFM

SLC30A1

6

Q9Y6M5
MMSLSVRPQRRLLSA

RIPOR1

1

Q6ZS17
MLFIRMLRRAGQSPA

TDH

1

Q8IZJ6
LMKSVRTRLRTPMNL

KLHL2

291

O95198