Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF4 PRAMEF9 PRAMEF27 PRAMEF11 PRAMEF15

6.89e-0782415GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF4 PRAMEF9 PRAMEF27 PRAMEF11 PRAMEF15

1.43e-0695415GO:0140767
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

4.84e-0655414GO:0042974
GeneOntologyMolecularFunctionsodium:phosphate symporter activity

SLC34A2 SLC34A1

2.68e-0412412GO:0005436
GeneOntologyMolecularFunctioniron ion binding

RIOX1 CYP4Z1 P3H2 CYP11B1

3.67e-04166414GO:0005506
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

5.75e-04187414GO:0016922
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

RIOX1 CYP4Z1 P3H2 CYP11B1

6.60e-04194414GO:0016705
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC34A2 SLC34A1

1.10e-0324412GO:0005315
GeneOntologyBiologicalProcessin utero embryonic development

SLC34A2 PRAMEF4 CPT2 GDF1 TIE1 SPEG PRAMEF11 PRAMEF15

2.30e-05596428GO:0001701
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

RIOX1 PRAMEF25 PRAMEF4 PRAMEF9 TERT ITGB3 PRAMEF27 PRAMEF11 PRAMEF15

5.39e-05875429GO:0045596
GeneOntologyBiologicalProcesschordate embryonic development

SLC34A2 IFT122 PRAMEF4 CPT2 GDF1 TIE1 SPEG PRAMEF11 PRAMEF15

7.05e-05906429GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

SLC34A2 IFT122 PRAMEF4 CPT2 GDF1 TIE1 SPEG PRAMEF11 PRAMEF15

8.55e-05929429GO:0009792
GeneOntologyBiologicalProcessnegative regulation of developmental process

RIOX1 PRAMEF25 PRAMEF4 PRAMEF9 TIE1 TERT ITGB3 PRAMEF27 PRAMEF11 PRAMEF15

1.31e-0412204210GO:0051093
GeneOntologyBiologicalProcessintracellular phosphate ion homeostasis

SLC34A2 SLC34A1

2.20e-0411422GO:0030643
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF4 PRAMEF9 PRAMEF27 PRAMEF11 PRAMEF15

3.69e-0847425GO:0031462
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

PRAMEF4 PRAMEF9 PRAMEF27 PRAMEF11 PRAMEF15

6.41e-05212425GO:0031461
GeneOntologyCellularComponentubiquitin ligase complex

AMFR PRAMEF4 PRAMEF9 PRAMEF27 PRAMEF11 PRAMEF15

6.87e-05352426GO:0000151
GeneOntologyCellularComponenttransferase complex

AMFR PHKG2 PRAMEF4 PRAMEF9 TERT P3R3URF PRAMEF27 PRAMEF11 PRAMEF15

1.02e-04963429GO:1990234
HumanPhenoDecreased plasma free carnitine

SCO1 CPT2

3.14e-053172HP:0008315
HumanPhenoAbnormality of the urinary system physiology

SCO1 SLC34A2 PHKG2 UBAC2 IFT122 CPT2 DYSF TERT SLC34A1 ITGB3 D2HGDH CYP11B1

5.11e-0511991712HP:0011277
HumanPhenoDecreased circulating carnitine concentration

SCO1 CPT2 SLC34A1

5.25e-0523173HP:0003234
HumanPhenoAbnormality of urine homeostasis

SCO1 SLC34A2 PHKG2 IFT122 CPT2 TERT SLC34A1 ITGB3 D2HGDH CYP11B1

6.05e-058031710HP:0003110
MousePhenoabnormal spermatogonia proliferation

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

3.76e-0647324MP:0002685
MousePhenoabnormal jejunum morphology

PRAMEF4 PRAMEF11 PRAMEF15

1.09e-0441323MP:0004002
MousePhenoabnormal male germ cell apoptosis

PRAMEF4 TERT PRAMEF27 PRAMEF11 PRAMEF15

1.82e-04236325MP:0008280
MousePhenoabnormal male germ cell physiology

PRAMEF4 TERT PRAMEF27 PRAMEF11 PRAMEF15

2.13e-04244325MP:0020362
MousePhenoabnormal stomach morphology

IFT122 SLC9A2 PRAMEF4 PRAMEF11 PRAMEF15

2.30e-04248325MP:0000470
MousePhenodigestive/alimentary phenotype

SLC34A2 IFT122 SLC9A2 PRAMEF4 GDF1 TIE1 TERT ITGB3 PRAMEF11 PRAMEF15 LRRC26

3.18e-0415003211MP:0005381
MousePhenoincreased kidney weight

PRAMEF4 CYP11B1 PRAMEF11 PRAMEF15

3.19e-04145324MP:0003917
MousePhenoabnormal germ cell physiology

PRAMEF4 TERT PRAMEF27 PRAMEF11 PRAMEF15

3.23e-04267325MP:0020363
MousePhenoabnormal duodenum morphology

PRAMEF4 PRAMEF11 PRAMEF15

4.13e-0464323MP:0003271
DomainPRAME_family

PRAMEF25 PRAMEF4 PRAMEF27 PRAMEF15

5.52e-0819384IPR026271
DomainNa_Pi_cotrans

SLC34A2 SLC34A1

1.21e-053382PF02690
DomainNa/Pi_transpt

SLC34A2 SLC34A1

1.21e-053382IPR003841
Domain-

LRFN1 PRAMEF25 PRAMEF4 PRAMEF27 PRAMEF15 LRRC26

4.27e-053213863.80.10.10
DomainL_dom-like

LRFN1 PRAMEF25 PRAMEF4 PRAMEF27 PRAMEF15 LRRC26

4.82e-05328386IPR032675
Domainfn3

LRFN1 TIE1 SPEG

4.33e-03162383PF00041
DomainCyt_P450_CS

CYP4Z1 CYP11B1

5.20e-0353382IPR017972
DomainCYTOCHROME_P450

CYP4Z1 CYP11B1

6.00e-0357382PS00086
Domain-

CYP4Z1 CYP11B1

6.20e-03583821.10.630.10
Domainp450

CYP4Z1 CYP11B1

6.20e-0358382PF00067
DomainFN3

LRFN1 TIE1 SPEG

6.25e-03185383SM00060
DomainEGF_extracell

TIE1 ITGB3

6.62e-0360382IPR013111
DomainEGF_2

TIE1 ITGB3

6.62e-0360382PF07974
DomainCyt_P450

CYP4Z1 CYP11B1

6.62e-0360382IPR001128
DomainFN3

LRFN1 TIE1 SPEG

7.64e-03199383PS50853
DomainFN3_dom

LRFN1 TIE1 SPEG

8.74e-03209383IPR003961
PathwayREACTOME_SODIUM_COUPLED_PHOSPHATE_COTRANSPORTERS

SLC34A2 SLC34A1

3.01e-055252M27345
PathwayREACTOME_SODIUM_COUPLED_PHOSPHATE_COTRANSPORTERS

SLC34A2 SLC34A1

3.01e-055252MM15085
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

9.67e-092043426694250
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

1.46e-082243431729367
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

2.51e-082543437451217
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

4.06e-082843425089626
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

1.03e-073543419389355
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF4 PRAMEF11 PRAMEF15

1.18e-061743323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF4 PRAMEF11 PRAMEF15

1.18e-061743337781892
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF4 PRAMEF11 PRAMEF15

1.42e-061843329731491
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF4 PRAMEF11 PRAMEF15

1.42e-061843323894331
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF4 PRAMEF11 PRAMEF15

1.42e-061843314675769
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF4 PRAMEF11 PRAMEF15

1.42e-061843312890732
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF4 PRAMEF11 PRAMEF15

1.42e-061843339181896
Pubmed

The role of an intracellular cysteine stretch in the sorting of the type II Na/phosphate cotransporter.

SLC34A2 SLC34A1

1.49e-06243217574207
Pubmed

Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate.

SLC34A2 SLC34A1

1.49e-06243217310099
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF4 PRAMEF11 PRAMEF15

1.68e-061943328604677
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF4 PRAMEF11 PRAMEF15

1.98e-062043316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF4 PRAMEF11 PRAMEF15

1.98e-062043321425410
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF4 PRAMEF11 PRAMEF15

3.06e-062343319480014
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF4 PRAMEF11 PRAMEF15

3.97e-062543312620990
Pubmed

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.

SLC34A2 SLC34A1

4.48e-06343220354864
Pubmed

Growth-related renal type II Na/Pi cotransporter.

SLC34A2 SLC34A1

4.48e-06343211880379
Pubmed

Upregulation of the Na⁺-coupled phosphate cotransporters NaPi-IIa and NaPi-IIb by B-RAF.

SLC34A2 SLC34A1

4.48e-06343224258620
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF4 PRAMEF11 PRAMEF15

4.49e-062643318500982
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF4 PRAMEF11 PRAMEF15

6.98e-063043338786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF4 PRAMEF11 PRAMEF15

8.52e-063243337889087
Pubmed

The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of plasma inorganic phosphate concentration.

SLC34A2 SLC34A1

8.94e-06443229398136
Pubmed

Targeted deletion of the tybe IIb Na(+)-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality.

SLC34A2 SLC34A1

8.94e-06443219233126
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF4 PRAMEF11 PRAMEF15

2.57e-054643317287250
Pubmed

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.

TIE1 ITGB3

3.12e-05743227695111
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF4 PRAMEF11 PRAMEF15

3.31e-055043331806660
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF4 PRAMEF11 PRAMEF15

5.18e-055843331598710
Pubmed

Expression of Phosphate Transporters during Dental Mineralization.

SLC34A2 SLC34A1

5.35e-05943228892649
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF4 PRAMEF11 PRAMEF15

5.45e-055943311279525
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

AMFR IFT122 FRRS1 PRAMEF4 PRAMEF11 PRAMEF15

6.49e-0556443621565611
Pubmed

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.

AMFR UBAC2

8.15e-051143226424800
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

FRRS1 PRAMEF4 DYSF PRAMEF11 PRAMEF15

8.37e-0536343514691545
Pubmed

Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice.

SLC34A2 SLC34A1

1.77e-041643224470103
Pubmed

Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.

SLC34A2 SLC34A1

1.77e-041643219679677
Pubmed

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

SLC34A1 CYP11B1

2.52e-04194327628695
Pubmed

TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.

AMFR UBAC2

4.76e-042643235961308
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

SCO1 AMFR FRRS1 PRAMEF4 CPT2 PRAMEF11 PRAMEF15

7.61e-04124243730973865
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

LRFN1 TIE1 SPEG

1.07e-0316243325826454
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SCO1 PHKG2 UBAC2 IFT122 LRFN1 TFB2M TM9SF2

1.09e-03132143727173435
InteractionPRAMEF4 interactions

PRAMEF4 PRAMEF9

1.04e-053382int:PRAMEF4
Cytoband1p36.21

PRAMEF25 PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

3.83e-09634351p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF25 PRAMEF4 PRAMEF9 PRAMEF27 PRAMEF11 ACAP3 PRAMEF15

3.11e-06681437chr1p36
Cytoband13q32.3

UBAC2 TM9SF2

2.14e-042343213q32.3
Cytoband2q35

SPEG SLC23A3

2.52e-03794322q35
Cytoband14q24.3

VRTN RIOX1

3.47e-039343214q24.3
CytobandEnsembl 112 genes in cytogenetic band chr13q32

UBAC2 TM9SF2

3.70e-0396432chr13q32
Cytoband9q34.3

C9orf163 LRRC26

4.48e-031064329q34.3
CytobandEnsembl 112 genes in cytogenetic band chr2q35

SPEG SLC23A3

6.56e-03129432chr2q35
GeneFamilyPRAME family

PRAMEF25 PRAMEF4 PRAMEF9 PRAMEF27 PRAMEF11 PRAMEF15

1.03e-1224286686
GeneFamilySolute carriers

SLC34A2 SLC9A2 SLC34A1 SLC23A3

3.03e-03395284752
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

PRAMEF4 SPEG PRAMEF11 PRAMEF15

2.11e-0657424MM1262
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF15

8.66e-0681424MM938
CoexpressionGSE17721_CTRL_VS_LPS_8H_BMDC_UP

PHKG2 FRRS1 TFB2M RGL2 D2HGDH

1.66e-05200425M3699
CoexpressionKINNEY_DNMT1_METHYLATION_TARGETS

PRAMEF4 PRAMEF11 PRAMEF15

2.21e-0534423MM955
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DYSF TIE1 RGL2 ITGB3 SPDYE3

7.38e-071764355d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

1.98e-06934343e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
Diseaseasthma

UBAC2 SLC9A2 TM9SF2 DYSF C6orf89 SLC34A1 D2HGDH

2.43e-05751357MONDO_0004979
Diseaseeosinophil count

UBAC2 SLC9A2 TM9SF2 DYSF C9orf163 C6orf89 TERT ITGB3 D2HGDH

4.41e-051488359EFO_0004842
Diseasevitamin C measurement

SLC34A1 SLC23A3

1.62e-0416352EFO_0600003
Diseasemyelodysplastic syndrome (is_marker_for)

TERT ITGB3

2.56e-0420352DOID:0050908 (is_marker_for)
Diseaseglioma

TERT D2HGDH

3.11e-0422352EFO_0005543
Diseaseadult onset asthma

SLC9A2 TM9SF2 D2HGDH

3.72e-04118353EFO_1002011
Diseaseglycocholate measurement

TM9SF2 DYSF

5.82e-0430352EFO_0010491
Diseasechildhood onset asthma

UBAC2 SLC9A2 C6orf89 D2HGDH

6.40e-04334354MONDO_0005405
DiseaseUterine leiomyoma, breast carcinoma

C6orf89 TERT

6.63e-0432352EFO_0000305, HP_0000131
Diseaserespiratory system disease

UBAC2 SLC9A2 D2HGDH

6.78e-04145353EFO_0000684
Diseaseretinal degeneration (implicated_via_orthology)

SCO1 IFT122

7.05e-0433352DOID:8466 (implicated_via_orthology)
Diseaseacute lymphoblastic leukemia (is_marker_for)

TM9SF2 TERT

7.49e-0434352DOID:9952 (is_marker_for)
Diseaseserum non-albumin protein measurement

TM9SF2 DYSF TERT ITGB3

8.55e-04361354EFO_0004568

Protein segments in the cluster

PeptideGeneStartEntry
WMLPLRRGARLLPLA

C9orf163

161

Q8N9P6
APMAPALEAPRRWRV

ACAP3

521

Q96P50
ERPFLVLPPLMEWIR

BTBD11

496

A6QL63
MVPRLLLRAWPRGPA

CPT2

1

P23786
MSRRDVLIKRWPPPL

IFT122

1176

Q9HBG6
RWPAQRPVPGIRMYQ

LRFN1

441

Q9P244
RPVPPVMWRLFRRRD

GDF1

56

P27539
WPRPRFPRMFKCSRR

P3R3URF

26

A0A087WWA1
LMVQAWPFRRLPLRP

PRAMEF15

56

P0DUQ1
ATPRRPAGLLMLLFW

LY75

6

O60449
MAALRRLLWPPPRVS

MICU3

1

Q86XE3
MRERIWAPPLLLLLP

P3H2

1

Q8IVL5
PPFWHRRQILMLRMI

PHKG2

231

P15735
LLWYPVPCTRLPIRM

SLC34A1

486

Q06495
TEHPRLRRPMPWLLL

PCDHAC2

11

Q9Y5I4
FRPPLHDPRRQMFNW

FRRS1

466

Q6ZNA5
LPFEAMPRRPGNRWL

CYP11B1

36

P15538
MPRRPGNRWLRLLQI

CYP11B1

41

P15538
MRARPRPRPLWATVL

ITGB3

1

P05106
PWRRPLNRSQMLREL

C6orf89

231

Q6UWU4
VMRPLGGQLWRFLPR

SCO1

11

O75880
QPSLERMPRLAWFPL

DYSF

1246

O75923
MLPRRPLAWPAWLLR

D2HGDH

1

Q8N465
RPLRPPQRARLLEKW

RGL2

321

O15211
LMVQAWPFRRLPLRP

PRAMEF25

56

A6NGN4
MWIPVVGLPRRLRLS

TFB2M

1

Q9H5Q4
LMVQAWPFRRLPLRP

PRAMEF27

56

A3QJZ7
RAARLFEWLIAPMPP

RIOX1

201

Q9H6W3
IFMALLLPRWFREAP

SLC23A3

461

Q6PIS1
MPLLFLERFPWPSLR

AMFR

1

Q9UKV5
RRWMIRALHLFPAPP

CYP4Z1

36

Q86W10
LWYPIPFTRLPIRMA

SLC34A2

501

O95436
LMVQSWPFRRLPLRP

PRAMEF4

56

O60810
LLRAPPERVWVTMPR

SPEG

1896

Q15772
NWRSLRAPLPPMLLL

SLC9A2

6

Q9UBY0
MVWRVPPFLLPILFL

TIE1

1

P35590
RPKHWFQLCRPMNPR

SPDYE3

481

A6NKU9
LMVQAWPFRRLPLRP

PRAMEF9

56

P0DUQ2
LMVQAWPFRRLPLRP

PRAMEF11

56

O60813
MSARLPVLSPPRWPR

TM9SF2

1

Q99805
LRVLAHMLRAPPWAR

SLX1A

111

Q9BQ83
HMLRAPPWARLPLTL

SLX1A

116

Q9BQ83
GMINWNRLFPPLRQR

UBAC2

271

Q8NBM4
ELLPLRMPLSRWQRR

VRTN

496

Q9H8Y1
PRRLPRLPQRYWQMR

TERT

376

O14746
MRGPSWSRPRPLLLL

LRRC26

1

Q2I0M4