Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	LHX2 ZBTB7A DEAF1 SOX21 ZBTB8B FOXB2 GATA4 SKOR1 SP5 GBX1 POU3F1 RUNX2 PHOX2B ZFX ZIC2	1.90e-06	1412	52	15	GO:0000981
GeneOntologyMolecularFunction	chromatin binding	LHX2 ARID1B TOX4 ASXL3 GATA4 CHD3 ASXL2 RUNX2 HCFC1 ZFX ZIC2	2.50e-06	739	52	11	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	LHX2 ZBTB7A DEAF1 SOX21 FOXB2 GATA4 SKOR1 SP5 GBX1 POU3F1 RUNX2 PHOX2B HCFC1 ZFX ZIC2	2.85e-06	1459	52	15	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	LHX2 ZBTB7A SOX21 FOXB2 GATA4 SKOR1 SP5 POU3F1 RUNX2 PHOX2B HCFC1 ZFX ZIC2	1.29e-05	1244	52	13	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	LHX2 ZBTB7A SOX21 FOXB2 GATA4 SKOR1 SP5 POU3F1 RUNX2 PHOX2B HCFC1 ZFX ZIC2	1.63e-05	1271	52	13	GO:0000987
GeneOntologyMolecularFunction	chromatin DNA binding	TOX4 RUNX2 HCFC1 ZFX ZIC2	7.29e-05	167	52	5	GO:0031490
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	LHX2 SOX21 GATA4 RUNX2 PHOX2B ZFX ZIC2	5.89e-04	560	52	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	LHX2 SOX21 GATA4 RUNX2 PHOX2B ZFX ZIC2	6.27e-04	566	52	7	GO:0001216
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	ASXL3 ASXL2	1.35e-03	21	52	2	GO:0042975
GeneOntologyMolecularFunction	SMAD binding	ZBTB7A GATA4 SKOR1	1.46e-03	86	52	3	GO:0046332
GeneOntologyMolecularFunction	delayed rectifier potassium channel activity	KCNA4 KCNS1	2.41e-03	28	52	2	GO:0005251
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	ZBTB7A DEAF1 SOX21 MAGED4 KMT5A GATA4 SKOR1 SP5 ID4 POU3F1 IRF2BPL CHD3 ASXL2 HCFC1 SAP30	3.79e-08	1053	53	15	GO:0000122
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	ZBTB7A DEAF1 SOX21 MAGED4 KMT5A GATA4 SKOR1 SP5 ID4 POU3F1 IRF2BPL CHD3 ASXL2 RUNX2 HCFC1 SAP30 ZIC2	3.84e-08	1399	53	17	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	ZBTB7A DEAF1 SOX21 MAGED4 KMT5A GATA4 SKOR1 SP5 ID4 POU3F1 IRF2BPL CHD3 ASXL2 RUNX2 HCFC1 SAP30 ZIC2	4.44e-08	1413	53	17	GO:1902679
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	LHX2 DEAF1 SOX21 CDK13 ASXL3 GATA4 ID4 POU3F1 IRF2BPL ASXL2 RUNX2 SPAG8 PHOX2B HCFC1 ZFX ZIC2	2.27e-07	1390	53	16	GO:0045944
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	ZBTB7A GATA4 SKOR1 RUNX2 SELENON LTBP4 SAP30 ZIC2	1.67e-05	445	53	8	GO:0141091
GeneOntologyBiologicalProcess	cell surface receptor protein serine/threonine kinase signaling pathway	ZBTB7A GATA4 SKOR1 RUNX2 SELENON LTBP4 SAP30 ZIC2	2.95e-05	482	53	8	GO:0007178
GeneOntologyBiologicalProcess	skeletal muscle cell differentiation	GATA4 PHOX2B SELENON SAP30	1.08e-04	96	53	4	GO:0035914
GeneOntologyBiologicalProcess	stem cell differentiation	SOX21 CDK13 CHD3 RUNX2 PHOX2B ZIC2	1.30e-04	306	53	6	GO:0048863
GeneOntologyCellularComponent	chromatin	LHX2 ARID1B TOX4 DEAF1 SOX21 KMT5A ZBTB8B FOXB2 GATA4 SP5 GBX1 POU3F1 CHD3 RUNX2 PHOX2B HCFC1 SAP30 ZFX	1.07e-08	1480	53	18	GO:0000785
GeneOntologyCellularComponent	nuclear protein-containing complex	ZBTB7A ARID1B UTP18 DEAF1 CDK13 ASXL3 GATA4 CHD3 ASXL2 RBM47 PRPF40A HCFC1 SAP30	2.92e-05	1377	53	13	GO:0140513
GeneOntologyCellularComponent	PR-DUB complex	ASXL3 ASXL2	3.77e-05	4	53	2	GO:0035517
MousePheno	lethality throughout fetal growth and development, complete penetrance	LHX2 ZBTB7A CDK13 GATA4 RUNX2 PHOX2B MAP3K4	2.55e-05	263	47	7	MP:0011099
Domain	HARE-HTH	ASXL3 ASXL2	2.37e-05	3	53	2	PF05066
Domain	ASXH	ASXL3 ASXL2	2.37e-05	3	53	2	PF13919
Domain	PHD_3	ASXL3 ASXL2	2.37e-05	3	53	2	PF13922
Domain	ASX-like_PHD	ASXL3 ASXL2	2.37e-05	3	53	2	IPR026905
Domain	ASX/ASX-like	ASXL3 ASXL2	2.37e-05	3	53	2	IPR024811
Domain	ASXH	ASXL3 ASXL2	2.37e-05	3	53	2	IPR028020
Domain	HB1/Asxl_HTH	ASXL3 ASXL2	2.37e-05	3	53	2	IPR007759
Domain	-	TOX4 SOX21 CHD3	5.10e-04	55	53	3	1.10.30.10
Domain	-	DEAF1 SKOR1	5.12e-04	12	53	2	3.10.390.10
Domain	SAND_dom-like	DEAF1 SKOR1	5.12e-04	12	53	2	IPR010919
Domain	HMG_box_dom	TOX4 SOX21 CHD3	8.32e-04	65	53	3	IPR009071
Domain	BTB	ZBTB7A KCNA4 ZBTB8B KCNS1	1.69e-03	180	53	4	SM00225
Domain	BTB/POZ_dom	ZBTB7A KCNA4 ZBTB8B KCNS1	1.87e-03	185	53	4	IPR000210
Domain	Homeobox_CS	LHX2 GBX1 POU3F1 PHOX2B	1.91e-03	186	53	4	IPR017970
Domain	SKP1/BTB/POZ	ZBTB7A KCNA4 ZBTB8B KCNS1	2.02e-03	189	53	4	IPR011333
Domain	ZF_PHD_2	ASXL3 CHD3 ASXL2	2.48e-03	95	53	3	PS50016
Domain	ZF_PHD_1	ASXL3 CHD3 ASXL2	2.56e-03	96	53	3	PS01359
Domain	K_chnl_volt-dep_Kv	KCNA4 KCNS1	2.65e-03	27	53	2	IPR003968
Domain	VG_K_chnl	KCNA4 KCNS1	3.94e-03	33	53	2	IPR028325
Domain	Homeobox	LHX2 GBX1 POU3F1 PHOX2B	4.35e-03	234	53	4	PF00046
Domain	HOMEOBOX_1	LHX2 GBX1 POU3F1 PHOX2B	4.48e-03	236	53	4	PS00027
Domain	HOX	LHX2 GBX1 POU3F1 PHOX2B	4.55e-03	237	53	4	SM00389
Domain	HOMEOBOX_2	LHX2 GBX1 POU3F1 PHOX2B	4.69e-03	239	53	4	PS50071
Domain	Homeobox_dom	LHX2 GBX1 POU3F1 PHOX2B	4.69e-03	239	53	4	IPR001356
Domain	-	LHX2 GBX1 POU3F1 PHOX2B	8.44e-03	283	53	4	1.10.10.60
Domain	HMG_box	TOX4 SOX21	9.93e-03	53	53	2	PF00505
Domain	BTB_2	KCNA4 KCNS1	9.93e-03	53	53	2	PF02214
Domain	T1-type_BTB	KCNA4 KCNS1	9.93e-03	53	53	2	IPR003131
Domain	HMG_BOX_2	TOX4 SOX21	1.03e-02	54	53	2	PS50118
Domain	HMG	TOX4 SOX21	1.03e-02	54	53	2	SM00398
Pathway	KEGG_MEDICUS_REFERENCE_DEUBIQUITINATION_OF_H2AK119	ASXL3 ASXL2 HCFC1	5.67e-05	26	41	3	M47923
Pubmed	A census of human transcription factors: function, expression and evolution.	LHX2 ZBTB7A TOX4 DEAF1 SOX21 GATA4 SKOR1 SP5 ID4 GBX1 POU3F1 RUNX2 PHOX2B ZFX ZIC2	3.95e-12	908	53	15	19274049
Pubmed	Human transcription factor protein interaction networks.	LHX2 ZBTB7A ARID1B IRS4 DEAF1 FBRS GATA4 ID4 IRF2BPL CHD3 ASXL2 PRPF40A HCFC1 GADD45GIP1	1.96e-08	1429	53	14	35140242
Pubmed	ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.	ASXL3 ASXL2 HCFC1	3.98e-07	10	53	3	32669118
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	JPH1 ZBTB7A ARID1B FBRS GATA4 CHD3 LTBP4 PRPF40A GADD45GIP1 SAP30 ZIC2	7.83e-07	1116	53	11	31753913
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	LHX2 TOX4 DEAF1 SOX21 ID4 POU3F1 PHOX2B ZFX MEX3C	1.15e-06	709	53	9	22988430
Pubmed	Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.	LHX2 ID4 GBX1 POU3F1	1.79e-06	57	53	4	35377797
Pubmed	[The Relationship between ASXL2 and ZBTB7A Gene Mutations and Prognosis in Patients with Acute Myeloid Leukemia].	ZBTB7A ASXL2	2.28e-06	2	53	2	33812414
Pubmed	Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study.	ZBTB7A ASXL2	2.28e-06	2	53	2	30251205
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZBTB7A UTP18 DEAF1 CDK13 IRF2BPL CHD3 PRPF40A SAP30 ZFX	2.36e-06	774	53	9	15302935
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	ZBTB7A TOX4 UTP18 CDK13 IRF2BPL CHD3 HCFC1	2.90e-06	410	53	7	26949251
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZBTB7A TOX4 UTP18 DEAF1 CDK13 CHD3 ASXL2 PRPF40A HCFC1 SAP30 ZFX	3.28e-06	1294	53	11	30804502
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZBTB7A TOX4 DEAF1 SOX21 ZBTB8B GATA4 POU3F1 CHD3 RUNX2	3.35e-06	808	53	9	20412781
Pubmed	The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells.	LHX2 SKOR1 PHOX2B	5.79e-06	23	53	3	23648511
Pubmed	Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.	ASXL3 ASXL2	6.83e-06	3	53	2	16412590
Pubmed	Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.	ASXL3 ASXL2	6.83e-06	3	53	2	25835095
Pubmed	Understanding the phenotypic spectrum of ASXL-related disease: Ten cases and a review of the literature.	ASXL3 ASXL2	6.83e-06	3	53	2	33751773
Pubmed	Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates.	LHX2 GATA4	1.36e-05	4	53	2	35247020
Pubmed	PNPT1, MYO15A, PTPRQ, and SLC12A2-associated genetic and phenotypic heterogeneity among hearing impaired assortative mating families in Southern India.	SLC12A2 MYO15A	1.36e-05	4	53	2	34374074
Pubmed	The genomic landscape of core-binding factor acute myeloid leukemias.	ZBTB7A ASXL2	1.36e-05	4	53	2	27798625
Pubmed	Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding.	ASXL3 ASXL2	1.36e-05	4	53	2	34536441
Pubmed	Interaction network of human early embryonic transcription factors.	ARID1B ASXL3 FBRS GATA4 SCAMP3 ASXL2	1.56e-05	351	53	6	38297188
Pubmed	NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.	LHX2 ID4 POU3F1	1.61e-05	32	53	3	20610746
Pubmed	The transcriptional control of trunk neural crest induction, survival, and delamination.	LHX2 PHOX2B ZIC2	1.93e-05	34	53	3	15691760
Pubmed	Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.	ID4 RUNX2	2.27e-05	5	53	2	20628571
Pubmed	Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs.	PHOX2B SAP30	2.27e-05	5	53	2	37551791
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZBTB7A IRS4 EPPK1 RUNX2 HCFC1 SAP30 ZIC2	2.84e-05	583	53	7	29844126
Pubmed	Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.	ID4 GBX1 POU3F1	3.17e-05	40	53	3	27657450
Pubmed	The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.	ASXL2 HCFC1	3.40e-05	6	53	2	24748658
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	LHX2 GATA4 ID4 PHOX2B SAP30 ZFX	4.48e-05	424	53	6	21731673
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	LHX2 ID4 GBX1 POU3F1	4.74e-05	130	53	4	19386638
Pubmed	Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.	ZBTB7A CHD3	4.76e-05	7	53	2	26816381
Pubmed	Gonadotropin-releasing hormone-1 (GnRH-1) is involved in tooth maturation and biomineralization.	GATA4 POU3F1	4.76e-05	7	53	2	17948256
Pubmed	GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.	LHX2 GATA4	4.76e-05	7	53	2	18577233
Pubmed	Graded and areal expression patterns of regulatory genes and cadherins in embryonic neocortex independent of thalamocortical input.	LHX2 POU3F1	4.76e-05	7	53	2	10594069
Pubmed	The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.	RUNX2 MAP3K4	4.76e-05	7	53	2	15262978
Pubmed	Congenital Diaphragmatic Hernia Overview	ARID1B GATA4 LTBP4	4.84e-05	46	53	3	20301533
Pubmed	Identification of NPM-ALK interacting proteins by tandem mass spectrometry.	IRS4 CDK13 MAP3K4	5.17e-05	47	53	3	14968112
Pubmed	Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus.	SP5 ID4 ZIC2	5.17e-05	47	53	3	22235033
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	LHX2 ID4 GBX1 POU3F1	5.33e-05	134	53	4	19030180
Pubmed	Genome-wide atlas of gene expression in the adult mouse brain.	FOXB2 GBX1 PHOX2B	7.84e-05	54	53	3	17151600
Pubmed	GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.	GATA4 RUNX2	8.15e-05	9	53	2	24932701
Pubmed	The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.	ASXL2 HCFC1	8.15e-05	9	53	2	26416890
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	GBX1 MYO15A	8.15e-05	9	53	2	23144817
Pubmed	Pou3f1 orchestrates a gene regulatory network controlling contralateral retinogeniculate projections.	POU3F1 ZIC2	8.15e-05	9	53	2	37590135
Pubmed	Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3.	GATA4 RUNX2	8.15e-05	9	53	2	28484278
Pubmed	Additional sex combs-like family genes are required for normal cardiovascular development.	ASXL3 ASXL2	8.15e-05	9	53	2	24860998
Pubmed	Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex.	LHX2 POU3F1	8.15e-05	9	53	2	15758185
Pubmed	Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.	UTP18 HCFC1	8.15e-05	9	53	2	15199122
Pubmed	Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.	SOX21 SKOR1 ID4	8.75e-05	56	53	3	33053343
Pubmed	Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord.	GBX1 ZIC2	1.02e-04	10	53	2	33996801
Pubmed	The -KTS splice variant of WT1 is essential for ovarian determination in mice.	GATA4 RUNX2	1.02e-04	10	53	2	37917714
Pubmed	The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.	ASXL2 HCFC1	1.02e-04	10	53	2	19815555
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	SLC12A2 MAGED4 PRPF40A HCFC1 ZIC2	1.15e-04	313	53	5	38270169
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MMP24 ARID1B KCNA4 CDK13 KCNS1 SCAMP3 HCFC1	1.16e-04	730	53	7	34857952
Pubmed	FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.	LHX2 ZIC2	1.24e-04	11	53	2	18547559
Pubmed	The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.	ZBTB7A CHD3	1.24e-04	11	53	2	23658227
Pubmed	An ex vivo system to study cellular dynamics underlying mouse peri-implantation development.	GATA4 POU3F1	1.24e-04	11	53	2	35063082
Pubmed	Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling.	LHX2 ID4	1.24e-04	11	53	2	23638021
Pubmed	Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.	GATA4 POU3F1	1.49e-04	12	53	2	27292645
Pubmed	RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription.	GATA4 POU3F1	1.49e-04	12	53	2	35981753
Pubmed	Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice.	POU3F1 PHOX2B	1.49e-04	12	53	2	38830761
Pubmed	NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.	CHD3 SAP30	1.49e-04	12	53	2	9885572
Pubmed	SoxE proteins are differentially required in mouse adrenal gland development.	POU3F1 PHOX2B	1.49e-04	12	53	2	18272785
Pubmed	Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons.	LHX2 POU3F1	1.49e-04	12	53	2	9247261
Pubmed	Transcriptome analysis of human gastric cancer.	ZBTB7A EPPK1 SOX21 GATA4 IRF2BPL SCAMP3 RBM47	1.64e-04	772	53	7	16341674
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	ARID1B TOX4 IRS4 FBRS HCFC1	1.67e-04	339	53	5	30415952
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	JPH1 IRS4 FBRS PRPF40A	1.74e-04	182	53	4	32239614
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ZBTB7A GATA4 SKOR1 POU3F1 RUNX2 PHOX2B	1.75e-04	544	53	6	28473536
Pubmed	Loss of the tumor suppressor BAP1 causes myeloid transformation.	ASXL2 HCFC1	1.76e-04	13	53	2	22878500
Pubmed	Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex.	LHX2 POU3F1	1.76e-04	13	53	2	12091317
Pubmed	LIM genes parcellate the embryonic amygdala and regulate its development.	LHX2 POU3F1	1.76e-04	13	53	2	15295034
Pubmed	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	GATA4 ID4	2.05e-04	14	53	2	20201924
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	PCLO HCFC1	2.05e-04	14	53	2	16452088
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TOX4 CDK13 GATA4 CHD3 RBM47 PRPF40A HCFC1 GADD45GIP1 MEX3C	2.07e-04	1371	53	9	36244648
Pubmed	The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.	LHX2 IRS4 ID4	2.09e-04	75	53	3	37298722
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	LHX2 SKOR1 POU3F1 RUNX2	2.09e-04	191	53	4	24146773
Pubmed	Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.	LHX2 SOX21 POU3F1	2.26e-04	77	53	3	21525287
Pubmed	Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.	CHD3 SAP30	2.36e-04	15	53	2	9804427
Pubmed	Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.	POU3F1 PHOX2B	2.36e-04	15	53	2	20144603
Pubmed	Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.	LHX2 PHOX2B	2.36e-04	15	53	2	17475798
Pubmed	Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.	POU3F1 PHOX2B	2.70e-04	16	53	2	17699610
Pubmed	Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).	CHD3 SAP30	2.70e-04	16	53	2	11784859
Pubmed	Specific glial populations regulate hippocampal morphogenesis.	LHX2 POU3F1	2.70e-04	16	53	2	19020026
Pubmed	Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation.	UTP18 GATA4	2.70e-04	16	53	2	20833366
Pubmed	Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis.	LHX2 SOX21	2.70e-04	16	53	2	22115758
Pubmed	Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification.	LHX2 ZIC2	2.70e-04	16	53	2	10693795
Pubmed	The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.	ASXL2 HCFC1	2.70e-04	16	53	2	20805357
Pubmed	Functional proteomics mapping of a human signaling pathway.	ARID1B TOX4 CDK13 CHD3 ASXL2 PRPF40A	2.74e-04	591	53	6	15231748
Pubmed	A genomic atlas of mouse hypothalamic development.	LHX2 IRS4 ID4 ZIC2	2.74e-04	205	53	4	20436479
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	ARID1B GATA4 CHD3	2.82e-04	83	53	3	28794006
Pubmed	Contribution of Hox genes to the diversity of the hindbrain sensory system.	LHX2 PHOX2B	3.05e-04	17	53	2	14960494
Pubmed	A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.	LHX2 POU3F1	3.05e-04	17	53	2	17694053
Pubmed	Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.	LHX2 PHOX2B	3.05e-04	17	53	2	12023301
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GATA4 ID4 ASXL2 HCFC1 GADD45GIP1 SAP30 ZIC2	3.09e-04	857	53	7	25609649
Pubmed	Ipsilateral and Contralateral Retinal Ganglion Cells Express Distinct Genes during Decussation at the Optic Chiasm.	LHX2 ZIC2	3.43e-04	18	53	2	27957530
Pubmed	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.	CHD3 SAP30	3.43e-04	18	53	2	9790534
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	CHD3 SAP30	3.43e-04	18	53	2	10444591
Pubmed	Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.	GATA4 MAP3K4	3.43e-04	18	53	2	23102580
Pubmed	Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence.	POU3F1 PHOX2B	3.43e-04	18	53	2	16790476
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	ARID1B SOX21 PCLO FBRS MYO15A	3.50e-04	398	53	5	35016035
Interaction	SMARCC2 interactions	LHX2 ZBTB7A ARID1B GATA4 CHD3 PRPF40A SAP30	3.24e-05	353	52	7	int:SMARCC2
Interaction	KDM6A interactions	LHX2 ASXL3 GATA4 ASXL2 HCFC1	6.04e-05	162	52	5	int:KDM6A
Interaction	ARID1A interactions	LHX2 ZBTB7A ARID1B GATA4 CHD3 SAP30	7.50e-05	276	52	6	int:ARID1A
Interaction	PCBP2 interactions	ASXL3 GATA4 SKOR1 CHD3 ASXL2 PRPF40A	9.48e-05	288	52	6	int:PCBP2
Interaction	XRCC6 interactions	ZBTB7A TOX4 DEAF1 ASXL3 GATA4 CHD3 ASXL2 RUNX2 PRPF40A HCFC1	1.11e-04	928	52	10	int:XRCC6
Interaction	SMARCA1 interactions	LHX2 ARID1B GATA4 CHD3 SAP30	1.22e-04	188	52	5	int:SMARCA1
Interaction	CSNK2A1 interactions	IRS4 UTP18 ASXL3 FBRS GATA4 CHD3 ASXL2 PRPF40A HCFC1 SAP30	1.42e-04	956	52	10	int:CSNK2A1
Interaction	HDAC3 interactions	ZBTB7A ARID1B GATA4 CHD3 RUNX2 SAP30	1.49e-04	313	52	6	int:HDAC3
Interaction	BACC1 interactions	GATA4 CHD3 HCFC1 SAP30	1.50e-04	104	52	4	int:BACC1
Interaction	YY1 interactions	LHX2 TOX4 CHD3 ASXL2 PRPF40A HCFC1 SAP30	1.57e-04	454	52	7	int:YY1
Interaction	SMARCA4 interactions	LHX2 ZBTB7A ARID1B GATA4 CHD3 PRPF40A SAP30	1.74e-04	462	52	7	int:SMARCA4
Interaction	FEV interactions	ZBTB7A ARID1B FBRS GATA4 ASXL2	1.75e-04	203	52	5	int:FEV
Interaction	CBX4 interactions	TOX4 PCLO FBRS CHD3 PRPF40A	1.83e-04	205	52	5	int:CBX4
Interaction	AR interactions	ZBTB7A ARID1B EPPK1 FBRS IRF2BPL CHD3 RUNX2 PRPF40A HCFC1 GADD45GIP1	1.91e-04	992	52	10	int:AR
Interaction	LIN9 interactions	LHX2 GATA4 CHD3 SAP30	1.92e-04	111	52	4	int:LIN9
Interaction	RAN interactions	ASXL3 GATA4 CHD3 ASXL2 SPAG8 HCFC1 SAP30	2.07e-04	475	52	7	int:RAN
Cytoband	6p22.3	HDGFL1 ID4	1.31e-03	46	53	2	6p22.3
Coexpression	GSE11367_CTRL_VS_IL17_TREATED_SMOOTH_MUSCLE_CELL_UP	FBRS FOXB2 MYO15A PHOX2B HCFC1	8.50e-06	137	53	5	M460
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#2	JPH1 LHX2 SOX21 PCLO IRF2BPL CHD3 LTBP4	7.68e-07	210	52	7	Facebase_RNAseq_e9.5_Olfactory Placode_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#1	JPH1 LHX2 SOX21 KMT5A PCLO PRPF40A MAP3K4	3.10e-06	259	52	7	Facebase_RNAseq_e8.5_Floor Plate_1000_K1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_100	LHX2 IRS4 SOX21 POU3F1 ZIC2	4.13e-06	98	52	5	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_100
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_100	LHX2 IRS4 SOX21 POU3F1 ZIC2	4.35e-06	99	52	5	Facebase_RNAseq_e8.5_Floor Plate_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_100	LHX2 IRS4 SOX21 POU3F1 ZIC2	4.57e-06	100	52	5	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#1	LHX2 TOX4 SLC12A2 PCLO CHD3 LTBP4 ZFX	9.25e-06	306	52	7	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_500_k-means-cluster#3	JPH1 LHX2 SOX21 KMT5A PCLO	1.03e-05	118	52	5	Facebase_RNAseq_e8.5_Floor Plate_500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	LHX2 SLC12A2 SOX21 PCLO ID4 ZFX	1.79e-05	225	52	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000	JPH1 LHX2 SOX21 PCLO ID4 POU3F1 IRF2BPL LTBP4 PRPF40A SAP30 ZIC2	2.09e-05	983	52	11	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000	JPH1 LHX2 IRS4 SOX21 PCLO ID4 POU3F1 CHD3 RUNX2 SAP30 ZIC2	2.15e-05	986	52	11	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000	JPH1 LHX2 IRS4 SOX21 KMT5A PCLO POU3F1 PRPF40A HCFC1 MAP3K4 ZIC2	2.31e-05	994	52	11	Facebase_RNAseq_e8.5_Floor Plate_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500	JPH1 LHX2 SOX21 PCLO ID4 POU3F1 SAP30 ZIC2	2.45e-05	493	52	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_500	JPH1 LHX2 IRS4 SOX21 KMT5A PCLO POU3F1 ZIC2	2.52e-05	495	52	8	Facebase_RNAseq_e8.5_Floor Plate_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	LHX2 IRS4 SOX21 PCLO ID4 POU3F1 SAP30 ZIC2	2.63e-05	498	52	8	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_500_k-means-cluster#1	JPH1 LHX2 SOX21 PCLO	2.91e-05	72	52	4	Facebase_RNAseq_e9.5_Olfactory Placode_500_K1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#2	LHX2 SOX21 ID4 POU3F1 CHD3 LTBP4	3.10e-05	248	52	6	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#2	JPH1 LHX2 SOX21 KMT5A PCLO POU3F1 MAP3K4	4.75e-05	395	52	7	Facebase_RNAseq_e8.5_Floor Plate_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000_k-means-cluster#2	LHX2 SOX21 PCLO ID4 CHD3 LTBP4	5.98e-05	279	52	6	Facebase_RNAseq_e10.5_Olfactory Pit_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#5	LHX2 TOX4 SLC12A2 ZFX	7.30e-05	91	52	4	Facebase_RNAseq_e9.5_Mandibular Arch_1000_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	JPH1 LHX2 SOX21 PCLO ID4 SAP30	8.60e-05	298	52	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	LHX2 SLC12A2 SOX21 KMT5A PCLO ID4 ASXL2 ZFX	9.20e-05	595	52	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#4	LHX2 SOX21 PCLO ID4	9.36e-05	97	52	4	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K4
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_100	IRS4 SOX21 POU3F1 ZIC2	9.74e-05	98	52	4	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_100	LHX2 IRS4 SOX21 PCLO	1.05e-04	100	52	4	Facebase_RNAseq_e10.5_Olfactory Pit_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_100	LHX2 IRS4 SOX21 ZIC2	1.05e-04	100	52	4	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_100
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000	JPH1 LHX2 IRS4 SOX21 PCLO IRF2BPL CHD3 RBM47 LTBP4 ZIC2	1.07e-04	973	52	10	Facebase_RNAseq_e9.5_Olfactory Placode_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	JPH1 SOX21 PCLO ID4 LTBP4 SAP30	1.45e-04	328	52	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_500	JPH1 LHX2 IRS4 SOX21 PCLO RBM47 ZIC2	1.84e-04	491	52	7	Facebase_RNAseq_e9.5_Olfactory Placode_500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_2500_k-means-cluster#4	JPH1 LHX2 SOX21 PCLO ID4 IRF2BPL CHD3 LTBP4	2.37e-04	683	52	8	Facebase_RNAseq_e9.5_Olfactory Placode_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000	LHX2 TOX4 SLC12A2 SOX21 PCLO ID4 POU3F1 ASXL2 ZFX	5.59e-04	979	52	9	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_induced-DefinitiveEndoderm_top-relative-expression-ranked_1000	JPH1 LHX2 MMP24 IRS4 ZBTB8B GATA4 SP5 RBM47 ZIC2	5.67e-04	981	52	9	PCBC_DE_1000
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_inducedDefinitiveEndoderm_fromBlastocyst-derived-iPSC_top-relative-expression-ranked_1000	JPH1 MMP24 IRS4 ZBTB8B GATA4 SP5 ID4 RBM47 ZIC2	5.67e-04	981	52	9	PCBC_DE_blastocyst_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000	LHX2 IRS4 SOX21 PCLO ID4 IRF2BPL CHD3 RBM47 LTBP4	5.80e-04	984	52	9	Facebase_RNAseq_e10.5_Olfactory Pit_1000
CoexpressionAtlas	e10.5_NeuroEpith_MedialEmin_top-relative-expression-ranked_100	LHX2 ID4 POU3F1	6.20e-04	68	52	3	Facebase_ST1_e10.5_NeuroEpith_MedialEmin_100
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_1000	IRS4 GATA4 IRF2BPL SELENON LTBP4 PRPF40A HCFC1 GADD45GIP1	7.60e-04	814	52	8	gudmap_developingGonad_e18.5_testes_1000
CoexpressionAtlas	DevelopingGonad_e11.5_testes_emap-3226_top-relative-expression-ranked_1000	LHX2 ASXL3 GATA4 IRF2BPL SELENON PRPF40A HCFC1 GADD45GIP1	9.54e-04	843	52	8	gudmap_developingGonad_e11.5_testes_1000
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_top-relative-expression-ranked_1000	LHX2 ASXL3 GATA4 IRF2BPL SELENON HCFC1 GADD45GIP1 MAP3K4	9.61e-04	844	52	8	gudmap_developingGonad_e11.5_testes and mesonephros_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3	LHX2 ZBTB7A TOX4 SLC12A2 ZFX	1.01e-03	314	52	5	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	JPH1 LHX2 SOX21 PCLO ID4 LTBP4 SAP30	1.02e-03	654	52	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
Computational	Genes in the cancer module 123.	LHX2 TOX4 ID4 POU3F1 PHOX2B ZFX	1.51e-04	247	36	6	MODULE_123
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A	GAS2L1 ZBTB7A CDK13 PCLO GATA4 KCNS1 ZFX	3.98e-07	200	53	7	5917_DN
Drug	Letrozole [112809-51-5]; Down 200; 14uM; PC3; HT_HG-U133A	GAS2L1 ZBTB7A DEAF1 SPAG8 MYO15A HCFC1	5.66e-06	193	53	6	4240_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	GAS2L1 LHX2 ZBTB7A DEAF1 SPAG8 MYO15A	6.18e-06	196	53	6	4227_DN
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A	LHX2 ZBTB7A TOX4 SPTLC2 FBRS GATA4	6.36e-06	197	53	6	6952_DN
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A	ZBTB7A DEAF1 CDK13 SPTLC2 ID4 SPAG8	6.55e-06	198	53	6	3897_DN
Drug	Ergocryptine-alpha [511-09-1]; Down 200; 7uM; MCF7; HT_HG-U133A	LHX2 DEAF1 GATA4 ID4 KCNS1 SPAG8	6.55e-06	198	53	6	3900_DN
Drug	0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A	SPTLC2 ID4 KCNS1 RUNX2 MYO15A LTBP4	6.74e-06	199	53	6	3777_UP
Drug	A25618	ZBTB7A DEAF1 KMT5A GATA4 ID4 POU3F1 RUNX2 GADD45GIP1 SAP30	6.91e-05	777	53	9	CID000005562
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	GAS2L1 ZBTB7A DEAF1 ID4 HCFC1	7.96e-05	190	53	5	4340_DN
Drug	Carcinine [56897-53-1]; Down 200; 22uM; PC3; HT_HG-U133A	GAS2L1 LHX2 CDK13 FBRS MYO15A	8.57e-05	193	53	5	4225_DN
Drug	Cefalonium [5575-21-3]; Down 200; 8.8uM; PC3; HT_HG-U133A	GAS2L1 ZBTB7A SPAG8 MYO15A HCFC1	8.57e-05	193	53	5	4245_DN
Drug	Ethynodiol diacetate [297-76-7]; Down 200; 10.4uM; MCF7; HT_HG-U133A	LHX2 DEAF1 FBRS CHD3 ZFX	8.57e-05	193	53	5	5024_DN
Drug	Dosulepin hydrochloride [897-15-4]; Down 200; 12uM; MCF7; HT_HG-U133A	DEAF1 SPTLC2 FBRS CHD3 HCFC1	8.57e-05	193	53	5	5986_DN
Drug	Diphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A	DEAF1 SPTLC2 FBRS HCFC1 ZFX	8.78e-05	194	53	5	7406_DN
Drug	5194442; Up 200; 20uM; PC3; HT_HG-U133A	DEAF1 CDK13 SPTLC2 CHD3 HCFC1	8.78e-05	194	53	5	6553_UP
Drug	Acetohexamide [968-81-0]; Down 200; 12.4uM; MCF7; HT_HG-U133A	ZBTB7A CDK13 ID4 LTBP4 HCFC1	8.78e-05	194	53	5	1707_DN
Drug	Miconazole [22916-47-8]; Down 200; 9.6uM; MCF7; HT_HG-U133A	LHX2 DEAF1 CDK13 SPTLC2 GATA4	8.78e-05	194	53	5	4960_DN
Drug	S-(+)-ibuprofen [51146-56-6]; Up 200; 19.4uM; PC3; HT_HG-U133A	ZBTB7A IRS4 SOX21 ID4 SPAG8	8.78e-05	194	53	5	6712_UP
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; PC3; HT_HG-U133A	CDK13 ID4 KCNS1 POU3F1 SPAG8	9.00e-05	195	53	5	3804_UP
Drug	Pepstatin A [26305-03-3]; Down 200; 5.8uM; PC3; HT_HG-U133A	ZBTB7A SOX21 CHD3 SPAG8 MYO15A	9.22e-05	196	53	5	4206_DN
Drug	Betonicine [515-25-3]; Up 200; 25.2uM; PC3; HT_HG-U133A	LHX2 MMP24 ZBTB7A ID4 KCNS1	9.22e-05	196	53	5	3745_UP
Drug	Buflomedil hydrochloride [35543-24-9]; Up 200; 11.6uM; HL60; HT_HG-U133A	GAS2L1 DEAF1 KCNS1 CHD3 ZFX	9.22e-05	196	53	5	1338_UP
Drug	F0447-0125; Down 200; 10uM; MCF7; HT_HG-U133A	MMP24 ZBTB7A CDK13 SPAG8 MYO15A	9.22e-05	196	53	5	6396_DN
Drug	Lumicolchicine gamma [6901-14-0]; Down 200; 10uM; PC3; HT_HG-U133A	LHX2 ZBTB7A SOX21 SPAG8 HCFC1	9.22e-05	196	53	5	4195_DN
Drug	Nomifensine maleate [32795-47-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A	IRS4 PCLO ID4 SPAG8 MYO15A	9.44e-05	197	53	5	7217_UP
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	ZBTB7A CDK13 SPTLC2 GATA4 HCFC1	9.44e-05	197	53	5	4702_DN
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; PC3; HT_HG-U133A	GAS2L1 LHX2 ZBTB7A DEAF1 HCFC1	9.44e-05	197	53	5	4336_DN
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Up 200; 14.6uM; MCF7; HT_HG-U133A	IRS4 SPTLC2 KCNS1 SPAG8 PHOX2B	9.44e-05	197	53	5	2892_UP
Drug	Aminohippuric acid [61-78-9]; Up 200; 20.6uM; MCF7; HT_HG-U133A	DEAF1 SPTLC2 PCLO KCNS1 LTBP4	9.44e-05	197	53	5	5394_UP
Drug	Dirithromycin [62013-04-1]; Up 200; 4.8uM; HL60; HG-U133A	ZBTB7A FBRS KCNS1 MYO15A HCFC1	9.67e-05	198	53	5	1712_UP
Drug	Streptomycin sulfate [3810-74-0]; Up 200; 2.8uM; MCF7; HT_HG-U133A	LHX2 ZBTB7A SPTLC2 FBRS ZFX	9.67e-05	198	53	5	7194_UP
Drug	Isocorydine (+) [475-67-2]; Up 200; 11.8uM; PC3; HT_HG-U133A	LHX2 MMP24 CDK13 ID4 MYO15A	9.67e-05	198	53	5	4505_UP
Drug	Tetracaone hydrochloride [136-47-0]; Up 200; 13.2uM; MCF7; HT_HG-U133A	ZBTB7A FBRS KCNS1 MYO15A ZFX	9.67e-05	198	53	5	7473_UP
Drug	Megestrol acetate [595-33-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A	DEAF1 SPTLC2 PCLO CHD3 HCFC1	9.67e-05	198	53	5	5013_DN
Drug	Sulconazole nitrate [61318-91-0]; Up 200; 8.6uM; PC3; HT_HG-U133A	SOX21 CDK13 GATA4 ID4 HCFC1	9.67e-05	198	53	5	6652_UP
Drug	Liothyronine [6893-02-3]; Up 200; 6.2uM; MCF7; HT_HG-U133A	IRS4 DEAF1 CDK13 KCNS1 LTBP4	9.67e-05	198	53	5	3324_UP
Drug	Acetopromazine maleate salt [3598-37-6]; Up 200; 9uM; PC3; HT_HG-U133A	IRS4 CDK13 PHOX2B HCFC1 ZFX	9.90e-05	199	53	5	4494_UP
Drug	Propranolol hydrochloride [318-98-9]; Down 200; 13.6uM; PC3; HT_HG-U133A	LHX2 ZBTB7A FBRS GATA4 ID4	9.90e-05	199	53	5	6759_DN
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A	EPPK1 FBRS CHD3 LTBP4 MAP3K4	9.90e-05	199	53	5	1648_DN
Drug	PNU-0251126 [267429-19-6]; Up 200; 10uM; PC3; HT_HG-U133A	LHX2 ZBTB7A SPAG8 PHOX2B HCFC1	1.01e-04	200	53	5	3689_UP
Drug	Carteolol hydrochloride [51781-21-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	LHX2 ZBTB7A DEAF1 FBRS HCFC1	1.01e-04	200	53	5	3276_DN
Drug	Pentetic acid [67-43-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A	GAS2L1 ZBTB7A ID4 HCFC1 ZFX	1.01e-04	200	53	5	5264_DN
Disease	neuroblastoma (is_implicated_in)	ARID1B PHOX2B	1.31e-04	10	51	2	DOID:769 (is_implicated_in)
Disease	Epilepsy, Cryptogenic	ARID1B SLC12A2 ASXL3	3.91e-04	82	51	3	C0086237
Disease	Awakening Epilepsy	ARID1B SLC12A2 ASXL3	3.91e-04	82	51	3	C0751111
Disease	Aura	ARID1B SLC12A2 ASXL3	3.91e-04	82	51	3	C0236018
Disease	Epilepsy	ARID1B SLC12A2 ASXL3	8.98e-04	109	51	3	C0014544
Disease	intellectual disability (is_implicated_in)	ARID1B CDK13	1.24e-03	30	51	2	DOID:1059 (is_implicated_in)
Disease	progressive supranuclear palsy	KCNA4 RUNX2	1.32e-03	31	51	2	MONDO_0019037
Disease	Acute Myeloid Leukemia, M1	GAS2L1 ZBTB7A ASXL2	1.33e-03	125	51	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	GAS2L1 ZBTB7A ASXL2	1.33e-03	125	51	3	C1879321

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAAAAAAAARARARA	ARID1B	6	Q8NFD5
AAEAARAAEAAKAAE	CDK13	461	Q14004
LVKAQRAAAAAAAAA	ASXL2	666	Q76L83
AQREAAAAAAVAAAA	ASXL3	1066	Q9C0F0
AAAAAAAAAAAAVIP	RBM47	491	A0AV96
ELAVTAAAEAAAQAA	HCFC1	1611	P51610
AAAEAAAQAAATEEA	HCFC1	1616	P51610
NRAAVAVAVARADEA	MMP24	61	Q9Y5R2
AAVAAAAAAAAAAAV	FOXB2	221	Q5VYV0
AASNRAARAAAAAAR	MAGED4	111	Q96JG8
AARAAAAAARTAFSQ	MAGED4	116	Q96JG8
VAAAAAAAAAAAAVV	KMT5A	11	Q9NQR1
AAAAAAAAVVAGQRR	KMT5A	16	Q9NQR1
AAEAERAAAAAAATA	HDGFL1	176	Q5TGJ6
GRAAAVAAAVASAAA	MYO15A	2966	Q9UKN7
TAHARAKADAADQAA	JPH1	381	Q9HDC5
RFLNQTAAAAADAEA	ITGAE	441	P38570
AAAAAAAAAVEQRSR	IRF2BPL	156	Q9H1B7
DAGAAIAAAEAAVQQ	PCLO	4911	Q9Y6V0
DAAAAAAAAAAAERL	POU3F1	26	Q03052
FNHADVAAAAAAAAA	LHX2	181	P50458
QAREAAAAVAAVAAG	KCNS1	246	Q96KK3
QRRRDAATAAAAAAA	OTUD7A	671	Q8TE49
AAAAAAAARCKAAEA	ID4	41	P47928
AAAAVVAAAAAAAAA	PRPF40A	276	O75400
AEAAAAAEAAAAAAE	FAM9A	201	Q8IZU1
SLAAAAAAAAAREAA	GATA4	116	P43694
ERKEEAAAAAAAAAA	FBRS	306	Q9HAH7
LAAAAAAAAATAARN	GBX1	121	Q14549
AAAVAAAAAVAAAAA	DEAF1	16	O75398
AAAVAAAAAAAAAAV	CHD3	206	Q12873
ANAVTEAARALAAAR	GAS2L1	66	Q99501
AVARAEAAARAEAAA	LTBP4	251	Q8N2S1
ARAAALAAAVAQDPA	GADD45GIP1	201	Q8TAE8
AAANAAAGAAENAFR	SCAMP3	331	O14828
RGAAAAAAAALAAVV	IRS4	16	O14654
AAAAAAAAAVAASRP	MAP3K4	1191	Q9Y6R4
QEAAAAAAAAAAAAA	RUNX2	71	Q13950
KAVAAAVAAAAAAAA	SKOR1	511	P84550
AAAAAIAVAAAEEER	UTP18	56	Q9Y5J1
RSALAAATAAAAAAA	SPAG8	41	Q99932
KAAAAAAAAAARVFF	SOX21	136	Q9Y651
AAAAAAAAAALQRGL	SP5	226	Q6BEB4
AAAVAAVVAAAAAAA	SAP30	16	O75446
TQEAAAAAAAAAARR	EPPK1	2621	P58107
RFDAREAAAAAAAAG	MEX3C	171	Q5U5Q3
RSSAAAAAAAAAGQI	SPTLC2	31	O15270
VSENAGRAAAAAAAA	SLC12A2	86	P55011
ALLAAAAAAAVRVCA	SELENON	36	Q9NZV5
EDAAAAAAAAAVHEQ	ZFX	331	P17010
QERAAAAAAAAAKNG	PHOX2B	156	Q99453
RSVLQAAAAAAAAAS	TOX4	421	O94842
AVAAAVAAVAAGDCN	ZBTB7A	201	O95365
AAAAAAAAAAVSAVH	ZIC2	461	O95409
EAAVAAAVAAAAAAA	ZBTB8B	131	Q8NAP8
SRAAAAAAVAAATAA	KCNA4	36	P22459