Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hexosyltransferase activity	B3GLCT B4GAT1 UGT2B4 UGT2B7 FUT8 B3GNT8	6.95e-05	211	66	6	GO:0016758
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	B3GLCT B4GAT1 UGT2B4 UGT2B7 B3GNT8	1.52e-04	153	66	5	GO:0008194
GeneOntologyMolecularFunction	glucuronosyltransferase activity	B4GAT1 UGT2B4 UGT2B7	2.09e-04	35	66	3	GO:0015020
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1B CACNA1E KCNC3 SCN4A SLC6A20 COX4I2 SLC15A3 SLC23A2 KCNK4	2.10e-04	627	66	9	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1B CACNA1E KCNC3 SCN4A SLC6A20 COX4I2 SLC15A3 SLC23A2 KCNK4	3.21e-04	664	66	9	GO:0008324
GeneOntologyMolecularFunction	glycosyltransferase activity	B3GLCT B4GAT1 UGT2B4 UGT2B7 FUT8 B3GNT8	3.76e-04	288	66	6	GO:0016757
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1B CACNA1E	3.82e-04	9	66	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1B CACNA1E	3.82e-04	9	66	2	GO:0099626
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1B CACNA1E ABCA4 KCNC3 SCN4A SLC6A20 SLC6A19 SLC35B2 COX4I2 SLC15A3 SLC23A2 KCNK4	4.34e-04	1180	66	12	GO:0022857
GeneOntologyMolecularFunction	acetylglucosaminyltransferase activity	B3GLCT B4GAT1 B3GNT8	5.04e-04	47	66	3	GO:0008375
GeneOntologyMolecularFunction	retinoid binding	ABCA4 UGT2B4 UGT2B7	5.36e-04	48	66	3	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	ABCA4 UGT2B4 UGT2B7	5.70e-04	49	66	3	GO:0019840
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1B CACNA1E KCNC3 SCN4A SLC6A20 COX4I2 SLC15A3 SLC23A2 KCNK4	8.32e-04	758	66	9	GO:0015318
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B CACNA1E KCNC3 SCN4A SLC6A20 SLC23A2 KCNK4	8.45e-04	465	66	7	GO:0046873
GeneOntologyMolecularFunction	transporter activity	CACNA1B CACNA1E ABCA4 KCNC3 SCN4A SLC6A20 SLC6A19 SLC35B2 COX4I2 SLC15A3 SLC23A2 KCNK4	9.50e-04	1289	66	12	GO:0005215
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1B CACNA1E	9.54e-04	14	66	2	GO:0008331
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCA4 SLC6A20 SLC6A19 SLC35B2 COX4I2 SLC15A3 SLC23A2	9.81e-04	477	66	7	GO:0022804
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1B CACNA1E KCNC3 SCN4A SLC6A20 COX4I2 SLC15A3 SLC23A2 KCNK4	1.14e-03	793	66	9	GO:0015075
GeneOntologyMolecularFunction	symporter activity	SLC6A20 SLC6A19 SLC15A3 SLC23A2	1.54e-03	150	66	4	GO:0015293
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1B CACNA1E KCNC3 KCNK4	1.61e-03	152	66	4	GO:0022843
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A20 SLC6A19 SLC35B2 SLC15A3 SLC23A2	2.96e-03	296	66	5	GO:0015291
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1B CACNA1E KCNC3 KCNK4	3.10e-03	182	66	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1B CACNA1E KCNC3 KCNK4	3.22e-03	184	66	4	GO:0022832
GeneOntologyMolecularFunction	retinoic acid binding	UGT2B4 UGT2B7	3.85e-03	28	66	2	GO:0001972
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1B CACNA1E KCNC3 SCN4A KCNK4	5.51e-03	343	66	5	GO:0005261
GeneOntologyMolecularFunction	deaminase activity	AMPD3 APOBEC3A	5.64e-03	34	66	2	GO:0019239
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC6A20 SLC23A2	5.97e-03	35	66	2	GO:0005343
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	AUP1 MARCHF6	6.30e-03	36	66	2	GO:0031624
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	AMPD3 APOBEC3A	6.30e-03	36	66	2	GO:0016814
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	ABCA4 SLC23A2	6.30e-03	36	66	2	GO:0090482
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A20 SLC15A3 SLC23A2	7.19e-03	119	66	3	GO:0015294
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC6A20 SLC6A19	8.12e-03	41	66	2	GO:0015175
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme binding	AUP1 MARCHF6	8.51e-03	42	66	2	GO:0044390
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CACNA1B SLC35G1 CACNA1E KCNC3 SCN4A SLC6A20 SLC6A19 RGS9 COX4I2 SLC15A3 SLC23A2 KCNK4	2.68e-05	922	65	12	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1B SLC35G1 CACNA1E KCNC3 SCN4A SLC6A20 SLC6A19 RGS9 COX4I2 SLC15A3 SLC23A2 KCNK4	3.30e-05	942	65	12	GO:0098655
GeneOntologyBiologicalProcess	monosaccharide metabolic process	B3GLCT GALT PIK3CA KBTBD2 FUT8 SLC23A2 LEP	5.34e-05	310	65	7	GO:0005996
GeneOntologyBiologicalProcess	monoatomic cation transport	CACNA1B SLC35G1 CACNA1E KCNC3 DSPP SCN4A SLC6A20 SLC6A19 RGS9 COX4I2 SLC15A3 SLC23A2 KCNK4	5.46e-05	1157	65	13	GO:0006812
GeneOntologyBiologicalProcess	glycoprotein metabolic process	B3GLCT B4GAT1 DHDDS SLC35B2 ADAMTS13 FUT8 LEP B3GNT8	5.97e-05	430	65	8	GO:0009100
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CACNA1B SLC35G1 CACNA1E KCNC3 SCN4A SLC6A20 SLC6A19 RGS9 COX4I2 SLC15A3 SLC23A2 KCNK4	6.93e-05	1017	65	12	GO:0098660
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1B SLC35G1 CACNA1E KCNC3 DSPP SCN4A SLC6A20 SLC6A19 RGS9 COX4I2 SLC15A3 SLC23A2 LEP KCNK4	7.78e-05	1374	65	14	GO:0006811
GeneOntologyBiologicalProcess	carbohydrate derivative metabolic process	AMPD3 B3GLCT GALT PEMT B4GAT1 ELOVL5 DHDDS SLC35B2 ADAMTS13 FUT8 LEP APOBEC3A B3GNT8	9.84e-05	1226	65	13	GO:1901135
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1B SLC35G1 CACNA1E KCNC3 SCN4A SLC6A20 SLC6A19 RGS9 COX4I2 SLC15A3 SLC23A2 KCNK4	1.65e-04	1115	65	12	GO:0034220
GeneOntologyBiologicalProcess	positive regulation of follicle-stimulating hormone secretion	INHA LEP	2.03e-04	7	65	2	GO:0046881
GeneOntologyBiologicalProcess	metal ion transport	CACNA1B SLC35G1 CACNA1E KCNC3 DSPP SCN4A SLC6A20 SLC6A19 RGS9 SLC23A2 KCNK4	2.66e-04	1000	65	11	GO:0030001
GeneOntologyBiologicalProcess	hexose metabolic process	B3GLCT GALT PIK3CA KBTBD2 FUT8 LEP	2.70e-04	284	65	6	GO:0019318
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B4 UGT2B7	2.70e-04	8	65	2	GO:0070980
GeneOntologyBiologicalProcess	positive regulation of gonadotropin secretion	INHA LEP	2.70e-04	8	65	2	GO:0032278
GeneOntologyBiologicalProcess	poly-N-acetyllactosamine biosynthetic process	B4GAT1 B3GNT8	3.47e-04	9	65	2	GO:0030311
GeneOntologyBiologicalProcess	regulation of follicle-stimulating hormone secretion	INHA LEP	3.47e-04	9	65	2	GO:0046880
GeneOntologyBiologicalProcess	poly-N-acetyllactosamine metabolic process	B4GAT1 B3GNT8	4.33e-04	10	65	2	GO:0030309
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B4 UGT2B7	4.33e-04	10	65	2	GO:0018879
GeneOntologyBiologicalProcess	circulatory system process	CACNA1B CACNA1E OXTR PIK3CA SCN4A SLC6A20 SLC23A2 CHRM3 LEP	4.64e-04	733	65	9	GO:0003013
GeneOntologyBiologicalProcess	regulation of neurotransmitter secretion	CACNA1B CACNA1E KCNC3 UNC13A	5.27e-04	118	65	4	GO:0046928
GeneOntologyBiologicalProcess	follicle-stimulating hormone secretion	INHA LEP	5.28e-04	11	65	2	GO:0046884
GeneOntologyCellularComponent	endoplasmic reticulum membrane	SLC35G1 B3GLCT PEMT AUP1 EBPL MARCHF6 PTDSS1 ELOVL5 UGT2B4 UGT2B7 DHDDS BFAR SLC35B2 ERMARD CHRM3 PHTF1	1.51e-06	1293	65	16	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	SLC35G1 B3GLCT PEMT AUP1 EBPL MARCHF6 PTDSS1 ELOVL5 UGT2B4 UGT2B7 DHDDS BFAR SLC35B2 ERMARD CHRM3 PHTF1	1.61e-06	1299	65	16	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	SLC35G1 B3GLCT PEMT AUP1 EBPL MARCHF6 PTDSS1 ELOVL5 UGT2B4 UGT2B7 DHDDS BFAR SLC35B2 ERMARD CHRM3 PHTF1	2.13e-06	1327	65	16	GO:0042175
GeneOntologyCellularComponent	presynaptic membrane	CACNA1E TENM3 KCNC3 RGS9 CHRM3 UNC13A	2.20e-04	277	65	6	GO:0042734
GeneOntologyCellularComponent	synaptic membrane	CACNA1E TENM3 KCNC3 NTRK3 SORCS2 RGS9 CHRM3 UNC13A	4.35e-04	583	65	8	GO:0097060
GeneOntologyCellularComponent	cation channel complex	CACNA1B CACNA1E KCNC3 SCN4A KCNK4	8.21e-04	235	65	5	GO:0034703
GeneOntologyCellularComponent	postsynaptic membrane	CACNA1E KCNC3 NTRK3 SORCS2 RGS9 CHRM3	1.61e-03	405	65	6	GO:0045211
MousePheno	abnormal glucose tolerance	CACNA1B CACNA1E RNF123 DSPP PIK3CA SCN4A MARCHF6 ELOVL5 COX4I2 CHRM3 LEP UNC13A	7.84e-06	787	47	12	MP:0005291
MousePheno	abnormal frequency of paradoxical sleep	CACNA1B CHRM3 LEP	3.32e-05	19	47	3	MP:0003194
MousePheno	decreased circulating glucagon level	CACNA1B CACNA1E CHRM3	3.90e-05	20	47	3	MP:0002696
MousePheno	decreased circulating leptin level	CACNA1B SCN4A KBTBD2 CHRM3 LEP	4.55e-05	118	47	5	MP:0005668
MousePheno	abnormal paradoxical sleep pattern	CACNA1B CHRM3 LEP	6.02e-05	23	47	3	MP:0012288
MousePheno	decreased circulating hormone level	CACNA1B CACNA1E INHA SCN4A SLC6A19 KBTBD2 SLC23A2 CHRM3 LEP	7.68e-05	551	47	9	MP:0014457
MousePheno	improved glucose tolerance	CACNA1B RNF123 DSPP SCN4A ELOVL5 COX4I2 CHRM3	8.00e-05	315	47	7	MP:0005292
MousePheno	abnormal hepatobiliary system physiology	GALT PEMT INHA A2ML1 ELOVL5 PXMP2 CHRM3 LEP	8.64e-05	433	47	8	MP:0002139
MousePheno	abnormal circulating leptin level	CACNA1B PIK3CA SCN4A KBTBD2 CHRM3 LEP	1.31e-04	236	47	6	MP:0005667
MousePheno	abnormal respiratory system physiology	AMPD3 NADSYN1 NTRK3 SCN4A MARCHF6 COX4I2 FUT8 SLC23A2 CHRM3 LEP UNC13A	1.47e-04	897	47	11	MP:0002133
MousePheno	decreased hormone level	CACNA1B CACNA1E INHA SCN4A SLC6A19 KBTBD2 SLC23A2 CHRM3 LEP	2.25e-04	635	47	9	MP:0014455
MousePheno	abnormal circulating glucagon level	CACNA1B CACNA1E CHRM3	3.23e-04	40	47	3	MP:0002695
MousePheno	abnormal liver physiology	GALT PEMT INHA A2ML1 ELOVL5 PXMP2 LEP	3.54e-04	401	47	7	MP:0000609
MousePheno	decreased glucagon secretion	CACNA1E CHRM3	3.92e-04	9	47	2	MP:0002711
MousePheno	fragmentation of sleep/wake states	CACNA1B LEP	3.92e-04	9	47	2	MP:0009436
MousePheno	decreased insulin secretion	CACNA1E CHRM3 LEP UNC13A	5.16e-04	111	47	4	MP:0003059
Domain	Channel_four-helix_dom	CACNA1B CACNA1E KCNC3 SCN4A	3.81e-05	57	62	4	IPR027359
Domain	-	CACNA1B CACNA1E KCNC3 SCN4A	3.81e-05	57	62	4	1.20.120.350
Domain	Na/ntran_symport_orphan	SLC6A20 SLC6A19	1.08e-04	5	62	2	IPR002438
Domain	VDCC_a1su_IQ	CACNA1B CACNA1E	2.25e-04	7	62	2	IPR014873
Domain	GPHH	CACNA1B CACNA1E	2.25e-04	7	62	2	PF16905
Domain	GPHH_dom	CACNA1B CACNA1E	2.25e-04	7	62	2	IPR031649
Domain	Ca_chan_IQ	CACNA1B CACNA1E	2.25e-04	7	62	2	SM01062
Domain	Ca_chan_IQ	CACNA1B CACNA1E	2.25e-04	7	62	2	PF08763
Domain	VDCCAlpha1	CACNA1B CACNA1E	4.80e-04	10	62	2	IPR002077
Domain	Ion_trans_dom	CACNA1B CACNA1E KCNC3 SCN4A	5.59e-04	114	62	4	IPR005821
Domain	Ion_trans	CACNA1B CACNA1E KCNC3 SCN4A	5.59e-04	114	62	4	PF00520
Domain	SNF	SLC6A20 SLC6A19	1.79e-03	19	62	2	PF00209
Domain	NA_NEUROTRAN_SYMP_1	SLC6A20 SLC6A19	1.79e-03	19	62	2	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A20 SLC6A19	1.79e-03	19	62	2	PS50267
Domain	Na/ntran_symport	SLC6A20 SLC6A19	1.79e-03	19	62	2	IPR000175
Domain	UDPGT	UGT2B4 UGT2B7	2.19e-03	21	62	2	PF00201
Domain	UDPGT	UGT2B4 UGT2B7	2.19e-03	21	62	2	PS00375
Domain	UDP_glucos_trans	UGT2B4 UGT2B7	2.19e-03	21	62	2	IPR002213
Pubmed	Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.	PIK3CA KBTBD2 LEP	5.44e-07	9	66	3	27708159
Pubmed	Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.	UGT2B4 UGT2B7	3.55e-06	2	66	2	10222050
Pubmed	Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.	CACNA1B CACNA1E	3.55e-06	2	66	2	15610184
Pubmed	Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.	CELA3B CELA3A	3.55e-06	2	66	2	27999401
Pubmed	Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice.	PIK3CA LEP	3.55e-06	2	66	2	18239469
Pubmed	Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.	UGT2B4 UGT2B7	3.55e-06	2	66	2	17263731
Pubmed	Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.	CACNA1B CACNA1E	3.55e-06	2	66	2	12074836
Pubmed	Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.	UGT2B4 UGT2B7	3.55e-06	2	66	2	15319348
Pubmed	Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency.	CHRM3 LEP	3.55e-06	2	66	2	17084710
Pubmed	Acute physical exercise increases PI3K-p110α protein content in the hypothalamus of obese mice.	PIK3CA LEP	3.55e-06	2	66	2	33094520
Pubmed	Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.	CELA3B CELA3A	3.55e-06	2	66	2	2826474
Pubmed	Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.	CELA3B CELA3A	3.55e-06	2	66	2	2460440
Pubmed	Leptin reverts pro-apoptotic and antiproliferative effects of α-linolenic acids in BCR-ABL positive leukemic cells: involvement of PI3K pathway.	PIK3CA LEP	3.55e-06	2	66	2	21991326
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1B CACNA1E KCNC3 SCN4A KCNK4	6.97e-06	139	66	5	16985003
Pubmed	Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.	UGT2B4 UGT2B7	1.06e-05	3	66	2	7835904
Pubmed	Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .	UGT2B4 UGT2B7	1.06e-05	3	66	2	29138287
Pubmed	Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus.	SLC6A20 SLC6A19	1.06e-05	3	66	2	16174864
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1B CACNA1E	1.06e-05	3	66	2	38996073
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1B CACNA1E	1.06e-05	3	66	2	24523520
Pubmed	Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.	UGT2B4 UGT2B7	1.06e-05	3	66	2	22092298
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	GALT INHA UGT2B4 UGT2B7 ADAMTS13 LEP	1.41e-05	275	66	6	20734064
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1B CACNA1E	2.12e-05	4	66	2	32616470
Pubmed	Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.	PIK3CA LEP	2.12e-05	4	66	2	21123564
Pubmed	Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer.	PIK3CA LEP	2.12e-05	4	66	2	23417417
Pubmed	Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol.	UGT2B4 UGT2B7	2.12e-05	4	66	2	16849011
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1B CACNA1E	2.12e-05	4	66	2	37141091
Pubmed	Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma.	PIK3CA LEP	2.12e-05	4	66	2	20008098
Pubmed	Essential role for collectrin in renal amino acid transport.	SLC6A20 SLC6A19	2.12e-05	4	66	2	17167413
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1B CACNA1E	3.53e-05	5	66	2	8825650
Pubmed	Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors.	SLC6A20 SLC6A19	3.53e-05	5	66	2	25534429
Pubmed	UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients.	UGT2B4 UGT2B7	3.53e-05	5	66	2	15318931
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1B CACNA1E	3.53e-05	5	66	2	15451373
Pubmed	Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.	ABCA4 UNC13A	3.53e-05	5	66	2	33139401
Pubmed	Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.	CELA3B CELA3A	3.53e-05	5	66	2	27358403
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1B CACNA1E	3.53e-05	5	66	2	11296258
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1B CACNA1E	5.29e-05	6	66	2	35324301
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1B CACNA1E	5.29e-05	6	66	2	12827191
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1B CACNA1E	5.29e-05	6	66	2	9238069
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1B CACNA1E	7.40e-05	7	66	2	35176221
Pubmed	Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people.	PEMT LEP	7.40e-05	7	66	2	20492333
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B4 UGT2B7	7.40e-05	7	66	2	26074487
Pubmed	Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma.	CHRM3 LEP	7.40e-05	7	66	2	23312282
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B4 UGT2B7	9.86e-05	8	66	2	32093886
Pubmed	Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.	UGT2B4 UGT2B7	9.86e-05	8	66	2	18052087
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1B CACNA1E	9.86e-05	8	66	2	28330839
Pubmed	Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.	UGT2B4 UGT2B7	9.86e-05	8	66	2	10748067
Pubmed	The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.	UGT2B4 UGT2B7	9.86e-05	8	66	2	18719240
Pubmed	Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.	UGT2B4 UGT2B7	9.86e-05	8	66	2	20142249
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1E	1.27e-04	9	66	2	16382099
Pubmed	The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.	CELA3B CELA3A	1.58e-04	10	66	2	19585519
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT2B4 UGT2B7	2.31e-04	12	66	2	20308471
Pubmed	Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.	UGT2B4 UGT2B7	2.31e-04	12	66	2	18161889
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	B4GAT1 AUP1 PTDSS1 ELOVL5 SLC23A2	2.52e-04	296	66	5	34186245
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	OXTR AUP1 MARCHF6 PTDSS1 ELOVL5 VPS25 CHRM3	3.52e-04	697	66	7	28298427
Pubmed	Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.	CELA3B CELA3A	3.67e-04	15	66	2	24793170
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1B CACNA1E	3.67e-04	15	66	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1B CACNA1E	3.67e-04	15	66	2	24453333
Pubmed	Identification of cAMP analogue inducible genes in RAW264 macrophages.	SLC15A3 SLC23A2	4.18e-04	16	66	2	11004510
Pubmed	Association analysis of 3p21 with Crohn's disease in a New Zealand population.	RNF123 CDHR4	4.74e-04	17	66	2	20307617
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCA4 PEMT UGT2B4 UGT2B7	5.06e-04	193	66	4	19343046
Pubmed	Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.	UGT2B4 UGT2B7	5.32e-04	18	66	2	20056724
Pubmed	The repertoire of solute carriers of family 6: identification of new human and rodent genes.	SLC6A20 SLC6A19	7.28e-04	21	66	2	16125675
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	OXTR CHRM3	7.28e-04	21	66	2	15452121
Pubmed	Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice.	CELA3B CELA3A	7.28e-04	21	66	2	16518820
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	PTDSS1 SORCS2 UGT2B7 FUT8 CHRM3 UNC13A PHTF1	8.81e-04	814	66	7	23251661
Pubmed	Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas.	CELA3B CELA3A	1.59e-03	31	66	2	22178591
Pubmed	Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.	CACNA1E SHB	1.59e-03	31	66	2	27321927
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC6A20 SLC6A19	1.59e-03	31	66	2	18195088
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	CACNA1B CACNA1E	1.70e-03	32	66	2	19320717
Cytoband	4q13	UGT2B4 UGT2B7	2.11e-04	15	66	2	4q13
GeneFamily	Solute carriers	SLC35G1 SLC6A20 SLC6A19 SLC35B2 SLC15A3 SLC23A2	3.66e-04	395	44	6	752
GeneFamily	Beta 3-glycosyltransferases	B3GLCT B3GNT8	1.54e-03	24	44	2	426
GeneFamily	Calcium voltage-gated channel subunits	CACNA1B CACNA1E	1.81e-03	26	44	2	253
GeneFamily	UDP glucuronosyltransferases	UGT2B4 UGT2B7	2.74e-03	32	44	2	363
Drug	brilliant blue	CELA3B CELA3A A2ML1 UGT2B7	1.07e-06	27	66	4	CID000017559
Drug	sipatrigine	CACNA1B CACNA1E SCN4A KCNK4	3.96e-06	37	66	4	CID000060803
Drug	mefenamic acid	SHB UGT2B4 UGT2B7 KCNK4	3.96e-06	37	66	4	CID000004044
Drug	norcepharadione B	CACNA1B CACNA1E	8.28e-06	2	66	2	CID000189168
Drug	aristolactam AII	CACNA1B CACNA1E	8.28e-06	2	66	2	CID000148657
Drug	alkosin	CACNA1B CACNA1E	8.28e-06	2	66	2	CID005488638
Drug	piperolactam A	CACNA1B CACNA1E	8.28e-06	2	66	2	CID003081016
Drug	valproate	CACNA1B CACNA1E SCN4A UGT2B4 UGT2B7 LEP NAGS PHTF1	1.41e-05	381	66	8	CID000003121
Drug	chloramine-T	B4GAT1 SCN4A SHB DHDDS LEP	1.42e-05	106	66	5	CID000031388
Drug	chromic phosphate	CACNA1E SLC35B2	2.48e-05	3	66	2	CID000062673
Drug	5 alpha-dihydroaldosterone	UGT2B4 UGT2B7	2.48e-05	3	66	2	CID003036614
Drug	halazepam	UGT2B4 UGT2B7 DHDDS	2.56e-05	20	66	3	CID000031640
Drug	AS-3201	UGT2B4 UGT2B7 DHDDS	4.51e-05	24	66	3	CID000153948
Drug	AC 110	CACNA1B CACNA1E	4.95e-05	4	66	2	CID000022860
Drug	2-PP	DSPP DHDDS	4.95e-05	4	66	2	CID005274974
Drug	AC1Q4I5I	CELA3B CELA3A	4.95e-05	4	66	2	CID000194288
Drug	mAHP	CACNA1B CACNA1E OXTR	6.47e-05	27	66	3	CID000220531
Drug	NSC-37538	DSPP SLC35B2	8.23e-05	5	66	2	CID000014464
Drug	hyodeoxycholic acid	UGT2B4 UGT2B7	8.23e-05	5	66	2	ctd:C010471
Drug	Amobarbital	UGT2B4 UGT2B7	8.23e-05	5	66	2	ctd:D000654
Drug	almagel	CACNA1B CACNA1E	8.23e-05	5	66	2	CID003080942
Drug	phenolphthalin	UGT2B4 UGT2B7	8.23e-05	5	66	2	CID000066494
Drug	beta-guanidinopropionic acid	AMPD3 LEP NAGS	8.93e-05	30	66	3	CID000067701
Drug	Tr-J	DSPP NTRK3 SCN4A	1.09e-04	32	66	3	CID000015133
Drug	N-acetyllactosamine	B3GLCT GALT B4GAT1 SLC35B2 FUT8	1.14e-04	164	66	5	CID000000245
Drug	2-hydroxyestriol	UGT2B4 UGT2B7	1.23e-04	6	66	2	CID000014688
Drug	3,4-dihydroquinazoline	CACNA1B CACNA1E	1.23e-04	6	66	2	CID000583065
Drug	alpha-sialylcholesterol	CACNA1B CACNA1E	1.23e-04	6	66	2	CID000133976
Drug	fenfluramine	ABCA4 SCN4A DHDDS CHRM3 LEP	1.68e-04	178	66	5	CID000003337
Drug	GBHA	DSPP DHDDS	1.72e-04	7	66	2	CID005356911
Drug	oxazepam glucuronide	UGT2B4 UGT2B7	1.72e-04	7	66	2	CID000160870
Drug	APMPA	CACNA1B CACNA1E	1.72e-04	7	66	2	CID000512300
Drug	ranirestat	UGT2B4 UGT2B7	1.72e-04	7	66	2	ctd:C115070
Disease	vitamin D measurement, COVID-19	NADSYN1 SLC6A20 UGT2B4 UGT2B7	4.22e-06	49	65	4	EFO_0004631, MONDO_0100096
Disease	HYPERGLYCINURIA (disorder)	SLC6A20 SLC6A19	1.43e-05	3	65	2	C0543541
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1B CACNA1E	1.43e-05	3	65	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1B CACNA1E	2.86e-05	4	65	2	DOID:6364 (implicated_via_orthology)
Disease	Iminoglycinuria	SLC6A20 SLC6A19	2.86e-05	4	65	2	C0268654
Disease	vitamin D deficiency	NADSYN1 UGT2B4 UGT2B7	7.51e-05	37	65	3	EFO_0003762
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1B CACNA1E	9.96e-05	7	65	2	DOID:0050951 (implicated_via_orthology)
Disease	Seizures	CACNA1B CACNA1E FUT8 LEP KCNK4	1.21e-04	218	65	5	C0036572
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B4 UGT2B7	1.70e-04	9	65	2	EFO_0600040
Disease	X-19141 measurement	UGT2B4 UGT2B7	3.67e-04	13	65	2	EFO_0800799
Disease	epilepsy (implicated_via_orthology)	CACNA1B CACNA1E SCN4A UNC13A	4.67e-04	163	65	4	DOID:1826 (implicated_via_orthology)
Disease	Schizophrenia	CACNA1B OXTR PEMT PIK3CA NTRK3 RGS9 FUT8 LEP	6.96e-04	883	65	8	C0036341
Disease	X-24947 measurement	UGT2B4 UGT2B7	1.07e-03	22	65	2	EFO_0800910
Disease	osteoporosis (biomarker_via_orthology)	DSPP LEP	1.07e-03	22	65	2	DOID:11476 (biomarker_via_orthology)
Disease	Carcinoma of lung	PIK3CA NTRK3	1.17e-03	23	65	2	C0684249
Disease	Disorder of eye	B3GLCT ABCA4 DHDDS RGS9	1.24e-03	212	65	4	C0015397
Disease	Hyperplasia	PIK3CA LEP	1.74e-03	28	65	2	C0020507

Protein segments in the cluster

Peptide	Gene	Start	Entry
YPAWFEPFVIQWLDE	UNC13A	1141	Q9UPW8
WNIDPVKVYFTWLAP	B3GLCT	466	Q6Y288
WNWLYFIPLIIIGSF	CACNA1E	326	Q15878
GTPLPWYFLLQESYW	ABCA4	866	P78363
AYVVPWQDPWEPFYV	B4GAT1	316	O43505
PAQIYRVTWFISWSP	APOBEC3A	86	P31941
QYFPETWLWDLFPIG	A2ML1	731	A8K2U0
SFVLWAPAILFWQYF	CHRM3	196	P20309
YFCIWAVAWAIPVPQ	DSPP	6	Q9NZW4
PFLEQLYCWAPWVQT	DNHD1	106	Q96M86
WNWLYFIPLIIIGSF	CACNA1B	331	Q00975
TDTEAFWQPQPWFVV	CDHR4	676	A6H8M9
FWQPQPWFVVVLTAT	CDHR4	681	A6H8M9
TYFQPKPRQAWVWAA	ADAMTS13	676	Q76LX8
SPEEWPNLAYWFIQH	AMPD3	446	Q01432
YRFQTPYFWPTQQWP	RGS9	101	O75916
WEIFTYGKQPWFQLS	NTRK3	761	Q16288
VIWPCTFPLGWLYFQ	ELOVL5	221	Q9NYP7
QDSPAYQPLVWFWIL	KCNK4	226	Q9NYG8
KTVWLYLQAWPNPVF	FCRL6	16	Q6DN72
YWFDAQQNTWFPKTP	KBTBD2	351	Q8IY47
WLWPYLFYVQAVPIQ	LEP	11	P41159
LDQTPLFYPWQDWAL	MARCHF6	751	O60337
WLYLFFFNGVWVLIP	EBPL	166	Q9BY08
LFWRSRVTNPINPWY	NAGS	471	Q8N159
FIQPWGPKAYITWIT	OXTR	191	P30559
FPWPEQVWFKASRVY	NPBWR2	201	P48146
PRWNEWLNYDIYIPD	PIK3CA	381	P42336
TITFNPLYWNVVARW	PEMT	21	Q9UBM1
WPLIPQFVCNCLFYW	BFAR	411	Q9NZS9
VPYSWPWQVSLQYEK	CELA3A	36	P09093
VLVPFWATWPYQTLL	GALT	241	P07902
VPYSWPWQVSLQYEK	CELA3B	36	P08861
WWFGTVLSQEPYQPQ	BRWD1	1081	Q9NSI6
FQELGWERWIVYPPS	INHA	271	P05111
EIRYAPWFQWTSFPE	ERMARD	91	Q5T6L9
IPLPFAYWNQQQWRL	B3GNT8	66	Q7Z7M8
VFQPVLWPEYTFWNL	DHDDS	226	Q86SQ9
YNAAPLSIWWQIPQY	SLC15A3	451	Q8IY34
AALVIWWQRVYVFPP	COX4I2	116	Q96KJ9
WWVSQFVKYLIRPQP	FUT8	326	Q9BYC5
IMWYLFNSFQEPLPW	SLC6A19	136	Q695T7
YDQPWEWNRVTIPAL	SHB	336	Q15464
VRWPPPFNDTNTTWY	SCN4A	281	P35499
WGVPQLLWYLVFLQP	NKPD1	26	Q17RQ9
LLPLNPNLTVFYWWI	SORCS2	896	Q96PQ0
WYLFHSFQDPLPWSV	SLC6A20	111	Q9NP91
LWSLFVPFTVYQVRW	AUP1	211	Q9Y679
LEVLPWPTEWIFNPY	TMEM31	71	Q5JXX7
EWPWQYRFPPFFTLQ	VPS25	6	Q9BRG1
VVFFPLFSNWWIQVT	PHTF1	81	Q9UMS5
WRVWTPLQFININYV	PXMP2	156	Q9NR77
LLVAPWFKVPYPFQW	SLC23A2	356	Q9UGH3
WLIRNYWDFQFPHPL	UGT2B4	256	P06133
APPESWTQLWFFRFV	SLC35B2	26	Q8TB61
APYEQRPWAQTNWIL	RNF123	956	Q5XPI4
YLFPPNFWIWTLATH	TMEM115	51	Q12893
PFLTQYHTVWIPWNV	TENM3	921	Q9P273
FLVTDWNPLTVWFYR	TTLL3	341	Q9Y4R7
FRYLQEIIVWPPLWD	PLEKHG7	491	Q6ZR37
FIFQIIFFNNVPTWW	SLC35G1	326	Q2M3R5
WLIRNSWNFQFPYPL	UGT2B7	256	P16662
LFPDPVVQWLYQYWP	TMEM177	36	Q53S58
FLKVPIWWYQLQGPS	USP40	931	Q9NVE5
QFTPASWTYVRWFDP	PTDSS1	266	P48651
YFKNIPIGFWWAVVT	KCNC3	486	Q14003
LRPFLYNTSWPWQFR	NADSYN1	671	Q6IA69