Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainSyntrophin

SNTB1 SNTB2

1.11e-045632IPR015482
DomainPDZ

MAST2 LNX1 SNTB1 SNTB2

1.31e-03141634PF00595
DomainPDZ

MAST2 LNX1 SNTB1 SNTB2

1.57e-03148634SM00228
Domain-

MAST2 LNX1 SNTB1 SNTB2

1.65e-031506342.30.42.10
DomainPDZ

MAST2 LNX1 SNTB1 SNTB2

1.69e-03151634PS50106
DomainPDZ

MAST2 LNX1 SNTB1 SNTB2

1.73e-03152634IPR001478
Pubmed

CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells.

CD28 CDC42

3.33e-06264212928366
Pubmed

CD28 Autonomous Signaling Up-Regulates C-Myc Expression and Promotes Glycolysis Enabling Inflammatory T Cell Responses in Multiple Sclerosis.

MYC CD28

3.33e-06264231212712
Pubmed

Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism.

MYC SNTB2

3.33e-06264212230428
Pubmed

Tripartite motif containing 33 demonstrated anticancer effect by degrading c‑Myc: Limitation of glutamine metabolism and proliferation in endometrial carcinoma cells.

MYC TRIM33

3.33e-06264237859625
Pubmed

STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.

MYC TAF2 MED13

6.63e-062064317967894
Pubmed

Differential expression of syntrophins and analysis of alternatively spliced dystrophin transcripts in the mouse brain.

SNTB1 SNTB2

9.99e-0636429182949
Pubmed

Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth.

MYC HEATR1

9.99e-06364238225354
Pubmed

Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24.

SNTB1 SNTB2

9.99e-0636428183929
Pubmed

Genetic mapping of the gene coding for the integrin beta 7 subunit to the distal part of mouse chromosome 15.

MYC ITGB7

9.99e-0636421349587
Pubmed

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.

MYC TRIM33

9.99e-06364227432991
Pubmed

Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5.

MYC RHOT1

9.99e-06364234406978
Pubmed

Differential targeting of components of the dystrophin complex to the postsynaptic membrane.

SNTB1 SNTB2

9.99e-06364211168526
Pubmed

Mice lacking α-, β1- and β2-syntrophins exhibit diminished function and reduced dystrophin expression in both cardiac and skeletal muscle.

SNTB1 SNTB2

9.99e-06364230256963
Pubmed

Human transcription factor protein interaction networks.

MYC TRIM33 NSA2 DHX40 MC1R MARF1 CPSF1 TAF2 JMJD1C SNTB1 SNTB2 RHOT1

1.00e-051429641235140242
Pubmed

Nef interaction with actin compromises human podocyte actin cytoskeletal integrity.

CDC42 SNTB1 SNTB2

1.03e-052364322721673
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

TRIM33 SETD5 NOC2L NSA2 DHX40 TAF1C DDX51 HEATR1 TAF2 CDC42 MED13 SNTB2

1.59e-051497641231527615
Pubmed

Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma.

MYC CDC42

2.00e-05464218937283
Pubmed

Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases.

MAST2 SNTB2

2.00e-05464210404183
Pubmed

Differential association of syntrophin pairs with the dystrophin complex.

SNTB1 SNTB2

3.32e-0556429214383
Pubmed

Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits.

TAF1C TAF2

3.32e-0556427801123
Pubmed

Assembly of multiple dystrobrevin-containing complexes in the kidney.

SNTB1 SNTB2

3.32e-05564210893187
Pubmed

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes.

SNTB1 SNTB2

3.32e-05564215310750
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

NOC2L NSA2 RNF213 DDX51 HEATR1 CDC42

3.40e-0533264625693804
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

METTL13 THADA SCAP SWAP70 RNF213 ASTN2 JMJD1C

3.41e-0549364715368895
Pubmed

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

MAST2 LNX1 SNTB1

3.41e-053464330726710
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

MYC TRIM33 METTL13 THADA SETD5 TAF1C RNF213 TAF2 MAST2 RHOT1

3.49e-051116641031753913
Pubmed

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.

MAST2 SNTB1 SNTB2

4.06e-053664326053890
Pubmed

MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.

MYC CDC42

4.98e-05664227566402
Pubmed

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.

MYC SCAP

4.98e-05664228784627
Pubmed

ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.

MYC CPSF1

4.98e-05664237040401
Pubmed

The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

SNTB1 SNTB2

4.98e-0566428576247
Pubmed

Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1.

LNX1 CDC42

4.98e-05664236192543
Pubmed

Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.

SNTB1 SNTB2

6.96e-05764211352924
Pubmed

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.

MYC TAF1C

6.96e-05764215723054
Pubmed

Lck regulates Vav activation of members of the Rho family of GTPases.

CD28 CDC42

9.27e-0586429032261
Pubmed

Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.

SNTB1 SNTB2

9.27e-05864216533813
Pubmed

Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.

SNTB1 SNTB2

9.27e-0586429412493
Pubmed

Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.

MYC CYP2C9 MC1R

1.46e-04556437873877
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MYC METTL13 NOC2L NSA2 DHX40 TAF1C CPSF1 DDX51 HEATR1 TAF2

1.72e-041353641029467282
Pubmed

Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.

SNTB1 SNTB2

1.81e-041164210995443
Pubmed

gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins.

SNTB1 SNTB2

1.81e-041164216857187
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DHX40 MARF1 HPS5 MAST2 MAP4K4 JMJD1C RHOT1

1.90e-0465064738777146
Pubmed

Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins.

SNTB1 SNTB2

2.99e-041464222937058
Pubmed

Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.

SNTB1 SNTB2

3.45e-041564223782696
Pubmed

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.

MYC MED13

3.45e-041564231285543
Pubmed

Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.

MYC RNF213

3.93e-041664229859889
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

SETD5 NOC2L NSA2 DHX40 HEATR1 TAF2

4.45e-0453364630554943
Pubmed

Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene.

MYC CYP2C9

4.45e-04176429680378
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

MYC TRIM33 NOC2L NSA2 DHX40 DDX51 HEATR1 JMJD1C

4.50e-0498964836424410
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

TMPRSS13 DHX40 MARF1 TAF2

4.86e-0419764420811636
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

MYC METTL13 NOC2L EBLN2 HEATR1 PKD1L3 MAST2 CDC42 JMJD1C

5.49e-04128464917353931
Pubmed

Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.

SNTB1 SNTB2

5.59e-041964215024025
Pubmed

A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6.

MYC CYP2C9

5.59e-04196428499946
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

TRIM33 METTL13 FMO2 NOC2L PACC1 HEATR1 MAST2 CDC42

5.91e-04103164816710414
Pubmed

NotI flanking sequences: a tool for gene discovery and verification of the human genome.

SNTB1 SNTB2

6.84e-042164212136098
Pubmed

Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.

MYC CDC42

7.52e-042264221502507
Pubmed

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

MYC THADA MED13

8.22e-049964319730683
Pubmed

GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.

THADA LNX1

8.23e-042364223725790
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

SWAP70 ASTN2 MAP4K4

8.96e-041026439734811
Pubmed

Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.

MYC CDC42

8.96e-042464219265663
Pubmed

Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses.

MYC SLC52A3

8.96e-042464218755693
Pubmed

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.

TAF2 MED13

9.73e-042564219240132
Pubmed

Functional proteomic analysis of human nucleolus.

NOC2L NSA2 HEATR1

1.00e-0310664312429849
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

MXRA5 NSA2 DHX40 DDX51 TAF2 SNTB2

1.13e-0363864631182584
Pubmed

Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef.

CD28 CDC42

1.14e-032764222844345
Pubmed

Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.

FMO2 CYP2C9

1.14e-032764220173083
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

SNTB1 SNTB2

1.14e-032764218468998
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SETD5 NOC2L NSA2 FAM161A MARF1 HEATR1 TEX14 STOX1 MED13

1.25e-03144264935575683
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

ZNF780A DHX40 JMJD1C

1.30e-0311664330804394
Pubmed

Defining the membrane proteome of NK cells.

MARF1 RNF213 DDX51 HEATR1 CDC42 ITGB7 MED13 RHOT1

1.32e-03116864819946888
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

MYC NOC2L EIF2B2 HEATR1

1.34e-0325964430404004
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

NOC2L NSA2 CPSF1 HEATR1 CDC42 SNTB2

1.35e-0366064632780723
Pubmed

Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.

FMO2 CYP2C9

1.40e-033064220529763
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

TRIM33 NOC2L RNF213 HEATR1

1.40e-0326264436880596
Pubmed

Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.

CYP2C9 SCAP

1.50e-033164220031551
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

CPSF1 SNTB1 SNTB2

1.61e-0312564329467281
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

TRIM33 THADA NSA2 TAF1C TAF2 MAST2

1.67e-0368964636543142
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

TRIM33 SCAP MARF1 HEATR1 MAST2 MED13 RHOT1 DMXL1

1.69e-03121564815146197
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

MYC SNTB2

1.70e-033364232140074
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

SWAP70 MAST2 MED13

1.80e-0313064312421765
InteractionABCA1 interactions

MYC LNX1 CDC42 SNTB1 SNTB2

6.07e-0754615int:ABCA1
InteractionRBM34 interactions

MYC NOC2L NSA2 DHX40 TAF1C DDX51 MAP4K4

2.67e-05290617int:RBM34
InteractionVPS52 interactions

MYC METTL13 FAM161A HEATR1 LNX1 CDC42

2.71e-05195616int:VPS52
InteractionADRA1D interactions

LNX1 SNTB1 SNTB2

3.38e-0521613int:ADRA1D
InteractionNOP2 interactions

MYC NOC2L NSA2 DHX40 TAF1C DDX51 CDC42 MAP4K4

3.49e-05416618int:NOP2
GeneFamilyPDZ domain containing

MAST2 LNX1 SNTB1 SNTB2

5.02e-041524441220
GeneFamilyMethyltransferase like

METTL13 METTL4

2.91e-0333442963
GeneFamilyRing finger proteins

TRIM33 RNF213 RNF183 LNX1

4.41e-0327544458
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

SWAP70 HEATR1

6.84e-0351442870
CoexpressionGSE13411_PLASMA_CELL_VS_MEMORY_BCELL_DN

TRIM33 MARF1 OSER1 HPS5 JMJD1C DMXL1

8.72e-06197646M3255
Diseasecortical thickness

THADA SLC27A6 SETD5 ASTN2 STOX1 MAST2 LNX1 CPED1 JMJD1C SNTB1

1.16e-0411136310EFO_0004840
Diseasecortical surface area measurement

THADA SLC27A6 CD28 ASTN2 STOX1 MAST2 LNX1 CPED1 MAP4K4 SNTB1 RHOT1

1.18e-0413456311EFO_0010736
Diseasecoronary artery disease

THADA LRFN2 SWAP70 SLC27A6 EIF2B2 RNF213 ASTN2 PKD1L3 LNX1 DMXL1

2.06e-0411946310EFO_0001645
Diseasecerebral cavernous malformation (implicated_via_orthology)

RNF213 CDC42

2.44e-0411632DOID:0060669 (implicated_via_orthology)
Diseasefacial morphology measurement

THADA CPED1 SNTB1 VPS13B RHOT1 SLC52A3

4.77e-04466636EFO_0007841
Diseasemuscular dystrophy (implicated_via_orthology)

SNTB1 SNTB2

9.18e-0421632DOID:9884 (implicated_via_orthology)
DiseaseUterine leiomyoma

SPDYC LNX1 SORCS1

9.86e-0491633HP_0000131
Diseaseneutrophil count, basophil count

THADA PCDHA12 MAST2 JMJD1C

1.36e-03224634EFO_0004833, EFO_0005090
Diseaselower face morphology measurement

SLC27A6 CPED1 VPS13B

1.66e-03109633EFO_0010948
Diseaseproteinuria (implicated_via_orthology)

HPS5 SORCS1

1.88e-0330632DOID:576 (implicated_via_orthology)
Diseasephysical activity measurement, body mass index

ASTN2 MAST2 GPRC5B

1.88e-03114633EFO_0004340, EFO_0008002
DiseaseC-reactive protein measurement, high density lipoprotein cholesterol measurement

JMJD1C SNTB1

2.41e-0334632EFO_0004458, EFO_0004612

Protein segments in the cluster

PeptideGeneStartEntry
TIIHVKGKHLCPSPL

CD28

131

P10747
PCHIKQIFTHPHLEL

CPED1

571

A4D0V7
HVVPCKFTISLAFPV

CFAP92

71

Q9ULG3
LPVSSPLCHAVLKTL

DMXL1

2516

Q9Y485
SCPLTVKVTLHVPEH

ASTN2

456

O75129
AHVTHPELKATFCLP

NSA2

181

O95478
PFFLHLTLIVLCPEH

MC1R

256

Q01726
SLAPHTLCTPKTIFL

LRCOL1

56

A6NCL2
DIYLPTHIQCSIKPH

MAP4K4

1106

O95819
SCLPLKHHMVTTPTL

EPHX4

286

Q8IUS5
KIEHELSRCSFHPIP

JMJD1C

676

Q15652
SFPKLLHLSEHCVLT

HPS5

291

Q9UPZ3
FPSILPSDIIQLCHH

HPS5

871

Q9UPZ3
KPPLHHQSKVITLCL

CPSF1

686

Q10570
LKIPPDCTTELNHHA

RHOT1

291

Q8IXI2
KSHFHPVTPSLVFLC

EBLN2

116

Q6P2I7
PLHPTITCHEKVVNI

LNX1

496

Q8TBB1
ITHHCPKTPFLLVGT

CDC42

101

P60953
HISVLVPCFLTFPKQ

NOC2L

276

Q9Y3T9
VSLQATHCLPEPHLL

ITGB7

441

P26010
LSCKHHYEVIPPLTS

PACC1

126

Q9H813
FHAIPEIHCTLLPAL

GPRC5B

286

Q9NZH0
LTFETPLVCHPHALL

GNPTG

161

Q9UJJ9
HHYVPCSLSSKPLVV

DDX51

481

Q8N8A6
LKSQPSCVIPISHFI

MARF1

1111

Q9Y4F3
LSLLIPSEHHTCSPL

MAST2

1056

Q6P0Q8
CSGHHILPHIPLKSF

FMO2

146

Q99518
FPHLCNVPDLITILH

HEATR1

321

Q9H583
LLPTSLPHAVTCDIK

CYP2C9

361

P11712
LAAKHHSTPLIVCAP

EIF2B2

256

P49770
SLPLFVHDHFPKSCI

METTL13

506

Q8N6R0
LTVCKPFDLHASPHA

FAM161A

451

Q3B820
FLKHSCPHPSEILGT

GPX5

151

O75715
LPPHLTCAVIKAASL

DHX40

491

Q8IX18
THTVPCAHQKPITAL

SCAP

1071

Q12770
SVPCTLHSHKPPLAE

METTL4

411

Q8N3J2
ICSLTPHVPFKLVST

PCDHA12

386

Q9UN75
CTFLPLPIVSEKHHI

MOXD2P

211

A6NHM9
ITPLLKLSCSDIHFH

OR1A1

181

Q9P1Q5
DLHSCPKPIVFIIHS

SNTB1

511

Q13884
PKVFHLTCHVPTLLS

TRIM33

906

Q9UPN9
PQTEHCVHLTPKEFL

THADA

1621

Q6YHU6
LHHFRPSCLSEVPII

SLC52A3

61

Q9NQ40
TVKELNLPTHPHCSR

TEX14

271

Q8IWB6
TPILIPSHHSLRECF

RNF183

141

Q96D59
HSSPKCLPPTLHLVC

TAF1C

446

Q15572
THFCLPQLLPLLKHT

TAF2

266

Q6P1X5
PHSPLVLKRCHVSTH

MYC

291

P01106
LPAHLSKTLCHPISQ

PKD1L3

191

Q7Z443
GLIHSPLICTTPKHY

SETD5

741

Q9C0A6
QCPLFLKASLHLHVP

MED13

2091

Q9UHV7
RSKSPVLHPPKFIHC

OSER1

81

Q9NX31
VLHPPKFIHCSTIAS

OSER1

86

Q9NX31
LLQLAHPTTHTPLCL

PRSS53

131

Q2L4Q9
LPHLPRKSVVHCSKI

RNF213

4726

Q63HN8
SKPLTLSAHIHPACL

TMPRSS13

421

Q9BYE2
VSAEHHICESTKPLP

STOX1

286

Q6ZVD7
LPQHCSSHLLKPVSS

SPDYC

221

Q5MJ68
EKLPTHTPHASLICN

ZNF780A

146

O75290
ETVPHTSKPCLLASL

VPS13B

2146

Q7Z7G8
SHNLCTVLKVPHDPV

SWAP70

36

Q9UH65
PRSHHVVSLLKSTCL

SLC27A6

206

Q9Y2P4
VTCPLEHVHLSLPFV

SORCS1

886

Q8WY21
SCPKPIVFVLHTFLS

SNTB2

516

Q13425
CEPPLITQHTHKLLV

LRFN2

286

Q9ULH4
HIHCTAKAAPLPSVR

MXRA5

2066

Q9NR99