Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA3 ABCA12 ABCA7 ATP8B2 ABCG1	2.43e-07	28	99	5	GO:0140326
GeneOntologyMolecularFunction	ATP-dependent activity	ACSL6 ABCA3 ABCA12 WRN ABCA7 ATP8B2 KIF20B DNAH14 DHX8 ABCG4 ABCG1 ACSM4 ATP6V1H ASCC3	2.00e-06	614	99	14	GO:0140657
GeneOntologyMolecularFunction	phosphatidylcholine transporter activity	ABCA3 ABCA7 ATP8B2 ABCG1	2.59e-06	20	99	4	GO:0008525
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	4.34e-06	49	99	5	GO:0140359
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ABCA3 ABCA12 ABCA7 ATP8B2 ABCG1	5.30e-06	51	99	5	GO:0140303
GeneOntologyMolecularFunction	phosphatidylcholine floppase activity	ABCA7 ATP8B2 ABCG1	6.50e-06	8	99	3	GO:0090554
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCA12 ABCG4 ABCG1	9.72e-06	9	99	3	GO:0034040
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA3 ABCA12 WRN ABCA7 ATP8B2 KIF20B DHX8 ABCG4 ABCG1 ATP6V1H ASCC3	1.18e-05	441	99	11	GO:0016887
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1 ATP6V1H	1.71e-05	109	99	6	GO:0042626
GeneOntologyMolecularFunction	ABC-type sterol transporter activity	ABCG4 ABCG1	2.43e-05	2	99	2	GO:0034041
GeneOntologyMolecularFunction	floppase activity	ABCA7 ATP8B2 ABCG1	6.32e-05	16	99	3	GO:0140328
GeneOntologyMolecularFunction	dihydrofolic acid binding	DHFR DHFR2	7.28e-05	3	99	2	GO:0051871
GeneOntologyMolecularFunction	dihydrofolate reductase activity	DHFR DHFR2	7.28e-05	3	99	2	GO:0004146
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	MTHFD1L DHFR DHFR2	9.14e-05	18	99	3	GO:0016646
GeneOntologyMolecularFunction	pyrophosphatase activity	EEFSEC ABCA3 CILP ABCA12 WRN ABCA7 ATP8B2 KIF20B DHX8 ABCG4 ABCG1 ATP6V1H ASCC3	2.54e-04	839	99	13	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	EEFSEC ABCA3 CILP ABCA12 WRN ABCA7 ATP8B2 KIF20B DHX8 ABCG4 ABCG1 ATP6V1H ASCC3	2.57e-04	840	99	13	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	EEFSEC ABCA3 CILP ABCA12 WRN ABCA7 ATP8B2 KIF20B DHX8 ABCG4 ABCG1 ATP6V1H ASCC3	2.57e-04	840	99	13	GO:0016818
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1 ATP6V1H	2.60e-04	178	99	6	GO:0015399
GeneOntologyMolecularFunction	phosphatidylcholine flippase activity	ABCA3 ATP8B2	3.60e-04	6	99	2	GO:0140345
GeneOntologyMolecularFunction	lipid transporter activity	ABCA3 ABCA12 ABCA7 ATP8B2 ABCG4 ABCG1	4.35e-04	196	99	6	GO:0005319
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH group of donors	MTHFD1L DHFR DHFR2	4.35e-04	30	99	3	GO:0016645
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	EEFSEC ABCA3 ABCA12 WRN ABCA7 ATP8B2 KIF20B DHX8 ABCG4 ABCG1 ATP6V1H ASCC3	4.49e-04	775	99	12	GO:0017111
GeneOntologyMolecularFunction	phospholipid transporter activity	ABCA3 ABCA7 ATP8B2 ABCG1	5.01e-04	74	99	4	GO:0005548
GeneOntologyMolecularFunction	volume-sensitive anion channel activity	LRRC8D LRRC8A	8.56e-04	9	99	2	GO:0005225
GeneOntologyMolecularFunction	telomeric DNA binding	WRN TERF1 KDM1A	1.02e-03	40	99	3	GO:0042162
GeneOntologyMolecularFunction	transporter activity	SCN11A ABCA3 ABCA12 LRRC8D ABCA7 ATP8B2 ITPR1 CUL5 ABCG4 ABCG1 ATP6V1H IGF1R KCNJ5 LRRC8A SEC63	1.67e-03	1289	99	15	GO:0005215
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR1 PLCL2	2.13e-03	14	99	2	GO:0070679
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ABCA3 ATP8B2	2.13e-03	14	99	2	GO:0140333
GeneOntologyMolecularFunction	3'-5' DNA helicase activity	WRN ASCC3	2.79e-03	16	99	2	GO:0043138
GeneOntologyMolecularFunction	mRNA regulatory element binding translation repressor activity	DHFR DHFR2	3.15e-03	17	99	2	GO:0000900
GeneOntologyMolecularFunction	flippase activity	ABCA3 ATP8B2	3.15e-03	17	99	2	GO:0140327
GeneOntologyMolecularFunction	NADP binding	HIBADH DHFR DHFR2	3.62e-03	62	99	3	GO:0050661
GeneOntologyMolecularFunction	cadherin binding involved in cell-cell adhesion	STXBP6 CNN3	3.94e-03	19	99	2	GO:0098641
GeneOntologyMolecularFunction	sequence-specific mRNA binding	DHFR DHFR2	3.94e-03	19	99	2	GO:1990825
GeneOntologyMolecularFunction	folic acid binding	DHFR DHFR2	4.36e-03	20	99	2	GO:0005542
GeneOntologyBiologicalProcess	positive regulation of cholesterol efflux	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	1.71e-07	27	99	5	GO:0010875
GeneOntologyBiologicalProcess	phospholipid efflux	ABCA3 ABCA12 ABCA7 ABCG1	6.54e-07	15	99	4	GO:0033700
GeneOntologyBiologicalProcess	positive regulation of sterol transport	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	1.32e-06	40	99	5	GO:0032373
GeneOntologyBiologicalProcess	positive regulation of cholesterol transport	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	1.32e-06	40	99	5	GO:0032376
GeneOntologyBiologicalProcess	tetrahydrofolate biosynthetic process	MTHFD1L DHFR DHFR2	5.90e-06	8	99	3	GO:0046654
GeneOntologyBiologicalProcess	regulation of cholesterol efflux	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	7.24e-06	56	99	5	GO:0010874
GeneOntologyBiologicalProcess	positive regulation of lipid transport	ACSL6 ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	9.74e-06	102	99	6	GO:0032370
GeneOntologyBiologicalProcess	lipid translocation	ABCA3 ABCA12 ABCA7 ATP8B2 ABCG1	1.02e-05	60	99	5	GO:0034204
GeneOntologyBiologicalProcess	organophosphate ester transport	ABCA3 ABCA12 LRRC8D ABCA7 ATP8B2 ABCG1 LRRC8A	1.32e-05	162	99	7	GO:0015748
GeneOntologyBiologicalProcess	regulation of membrane lipid distribution	ABCA3 ABCA12 ABCA7 ATP8B2 ABCG1	1.51e-05	65	99	5	GO:0097035
GeneOntologyBiologicalProcess	folic acid-containing compound biosynthetic process	MTHFD1L DHFR DHFR2	2.29e-05	12	99	3	GO:0009396
GeneOntologyBiologicalProcess	cholesterol efflux	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	3.46e-05	77	99	5	GO:0033344
GeneOntologyBiologicalProcess	positive regulation of lipid localization	ACSL6 ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	3.71e-05	129	99	6	GO:1905954
GeneOntologyBiologicalProcess	regulation of cholesterol transport	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	4.97e-05	83	99	5	GO:0032374
GeneOntologyBiologicalProcess	regulation of sterol transport	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	4.97e-05	83	99	5	GO:0032371
GeneOntologyBiologicalProcess	tetrahydrofolate interconversion	MTHFD1L DHFR DHFR2	5.74e-05	16	99	3	GO:0035999
GeneOntologyBiologicalProcess	response to methotrexate	DHFR DHFR2	6.82e-05	3	99	2	GO:0031427
GeneOntologyBiologicalProcess	pteridine-containing compound biosynthetic process	MTHFD1L DHFR DHFR2	6.95e-05	17	99	3	GO:0042559
GeneOntologyBiologicalProcess	regulation of phospholipid efflux	ABCA3 ABCA7	1.36e-04	4	99	2	GO:1902994
GeneOntologyBiologicalProcess	positive regulation of phospholipid efflux	ABCA3 ABCA7	1.36e-04	4	99	2	GO:1902995
GeneOntologyBiologicalProcess	cellular response to high density lipoprotein particle stimulus	ABCG4 ABCG1	1.36e-04	4	99	2	GO:0071403
GeneOntologyBiologicalProcess	dihydrofolate metabolic process	DHFR DHFR2	1.36e-04	4	99	2	GO:0046452
GeneOntologyBiologicalProcess	phospholipid transport	ABCA3 ABCA12 ABCA7 ATP8B2 ABCG1	1.59e-04	106	99	5	GO:0015914
GeneOntologyBiologicalProcess	tetrahydrofolate metabolic process	MTHFD1L DHFR DHFR2	1.77e-04	23	99	3	GO:0046653
GeneOntologyBiologicalProcess	regulation of lipid transport	ACSL6 ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	2.26e-04	179	99	6	GO:0032368
GeneOntologyBiologicalProcess	B cell proliferation involved in immune response	TLR4 PLCL2	3.38e-04	6	99	2	GO:0002322
GeneOntologyBiologicalProcess	cholesterol transport	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	4.71e-04	134	99	5	GO:0030301
GeneOntologyBiologicalProcess	sterol transport	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	5.57e-04	139	99	5	GO:0015918
GeneOntologyBiologicalProcess	folic acid-containing compound metabolic process	MTHFD1L DHFR DHFR2	5.76e-04	34	99	3	GO:0006760
GeneOntologyBiologicalProcess	regulation of lipid localization	ACSL6 ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	5.99e-04	215	99	6	GO:1905952
GeneOntologyBiologicalProcess	regulation of removal of superoxide radicals	DHFR DHFR2	6.27e-04	8	99	2	GO:2000121
GeneOntologyBiologicalProcess	cyclic-GMP-AMP transmembrane import across plasma membrane	LRRC8D LRRC8A	6.27e-04	8	99	2	GO:0140361
GeneOntologyBiologicalProcess	alkanesulfonate transmembrane transport	LRRC8D LRRC8A	6.27e-04	8	99	2	GO:0042918
GeneOntologyBiologicalProcess	taurine transmembrane transport	LRRC8D LRRC8A	6.27e-04	8	99	2	GO:0015734
GeneOntologyBiologicalProcess	superoxide metabolic process	CD177 DHFR DHFR2 PREX1	6.86e-04	83	99	4	GO:0006801
GeneOntologyBiologicalProcess	lipid transport	ACSL6 ABCA3 ABCA12 ABCA7 ATP8B2 ABCG4 ABCG1 VPS13D VPS13B	7.35e-04	506	99	9	GO:0006869
GeneOntologyBiologicalProcess	amide metabolic process	ACSL6 ABCA12 DYRK1A ABCA7 ABCG1 ACSM4 DHFR DHFR2 AADAT	7.88e-04	511	99	9	GO:0043603
GeneOntologyBiologicalProcess	positive regulation of steroid biosynthetic process	ABCG4 ABCG1 IGF1R	8.01e-04	38	99	3	GO:0010893
GeneOntologyBiologicalProcess	protein hexamerization	LRRC8D LRRC8A	8.03e-04	9	99	2	GO:0034214
GeneOntologyBiologicalProcess	tetrahydrobiopterin biosynthetic process	DHFR DHFR2	8.03e-04	9	99	2	GO:0006729
GeneOntologyBiologicalProcess	telomere maintenance via semi-conservative replication	WRN TERF1	8.03e-04	9	99	2	GO:0032201
GeneOntologyBiologicalProcess	glycine biosynthetic process	DHFR DHFR2	8.03e-04	9	99	2	GO:0006545
GeneOntologyCellularComponent	lamellar body membrane	ABCA3 ABCA12	1.27e-04	4	97	2	GO:0097232
Domain	ABC_transporter_CS	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	2.62e-06	42	98	5	IPR017871
Domain	ABC_tran	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	5.14e-06	48	98	5	PF00005
Domain	ABC_TRANSPORTER_2	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	5.14e-06	48	98	5	PS50893
Domain	ABC_TRANSPORTER_1	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	5.70e-06	49	98	5	PS00211
Domain	ABC_transporter-like	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	6.31e-06	50	98	5	IPR003439
Domain	DHFR_1	DHFR DHFR2	2.73e-05	2	98	2	PF00186
Domain	DHFR_1	DHFR DHFR2	2.73e-05	2	98	2	PS00075
Domain	DHFR_dom	DHFR DHFR2	2.73e-05	2	98	2	IPR001796
Domain	ABCG1	ABCG4 ABCG1	2.73e-05	2	98	2	IPR020064
Domain	DHFR_2	DHFR DHFR2	2.73e-05	2	98	2	PS51330
Domain	-	DHFR DHFR2	2.73e-05	2	98	2	3.40.430.10
Domain	DHFR-like_dom	DHFR DHFR2	2.73e-05	2	98	2	IPR024072
Domain	DHFR	DHFR DHFR2	2.73e-05	2	98	2	IPR012259
Domain	ABC_A	ABCA3 ABCA12 ABCA7	2.98e-05	12	98	3	IPR026082
Domain	AAA	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1 ASCC3	1.11e-04	144	98	6	SM00382
Domain	AAA+_ATPase	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1 ASCC3	1.11e-04	144	98	6	IPR003593
Domain	Sec63	ASCC3 SEC63	1.62e-04	4	98	2	PF02889
Domain	Sec63	ASCC3 SEC63	1.62e-04	4	98	2	SM00973
Domain	SHR-BD	VPS13D VPS13B	1.62e-04	4	98	2	IPR009543
Domain	Sec63-dom	ASCC3 SEC63	1.62e-04	4	98	2	IPR004179
Domain	Peptidase_C12	UCHL1 UCHL3	1.62e-04	4	98	2	PF01088
Domain	Peptidase_C12_UCH	UCHL1 UCHL3	1.62e-04	4	98	2	IPR001578
Domain	Calponin/LIMCH1	CNN2 CNN3	1.62e-04	4	98	2	IPR001997
Domain	VPS13_C	VPS13D VPS13B	1.62e-04	4	98	2	PF16909
Domain	VPS13_C	VPS13D VPS13B	1.62e-04	4	98	2	IPR031645
Domain	UCH_1	UCHL1 UCHL3	1.62e-04	4	98	2	PS00140
Domain	SHR-BD	VPS13D VPS13B	1.62e-04	4	98	2	PF06650
Domain	-	UCHL1 UCHL3	1.62e-04	4	98	2	3.40.532.10
Domain	LRRC8_Pannexin-like	LRRC8D LRRC8A	2.70e-04	5	98	2	IPR021040
Domain	ABC2_membrane	ABCG4 ABCG1	2.70e-04	5	98	2	PF01061
Domain	ABC_2_trans	ABCG4 ABCG1	2.70e-04	5	98	2	IPR013525
Domain	Pannexin_like	LRRC8D LRRC8A	2.70e-04	5	98	2	PF12534
Domain	Calponin_repeat	CNN2 CNN3	4.03e-04	6	98	2	IPR000557
Domain	Calponin	CNN2 CNN3	4.03e-04	6	98	2	PF00402
Domain	CALPONIN_1	CNN2 CNN3	4.03e-04	6	98	2	PS01052
Domain	CALPONIN_2	CNN2 CNN3	4.03e-04	6	98	2	PS51122
Domain	P-loop_NTPase	EEFSEC ABCA3 ABCA12 MTHFD1L WRN ABCA7 KIF20B DNAH14 DHX8 ABCG4 ABCG1 GTPBP8 ASCC3	4.81e-04	848	98	13	IPR027417
Domain	-	EEFSEC ABCA3 ABCA12 MTHFD1L WRN ABCA7 DNAH14 DHX8 ABCG4 ABCG1 GTPBP8 ASCC3	5.26e-04	746	98	12	3.40.50.300
Domain	Chorein_N	VPS13D VPS13B	7.48e-04	8	98	2	PF12624
Domain	VPS13_N	VPS13D VPS13B	7.48e-04	8	98	2	IPR026854
Domain	SM22_calponin	CNN2 CNN3	1.45e-03	11	98	2	IPR003096
Domain	WHTH_DNA-bd_dom	DEPTOR WRN CUL5 ASCC3 PREX1 KDM1A	1.73e-03	242	98	6	IPR011991
Domain	CH	SYNE1 CNN2 CNN3	4.84e-03	65	98	3	SM00033
Domain	RCC1	NEK9 HERC1	4.87e-03	20	98	2	PF00415
Domain	RCC1_1	NEK9 HERC1	5.36e-03	21	98	2	PS00625
Domain	RCC1_2	NEK9 HERC1	5.36e-03	21	98	2	PS00626
Domain	RCC1_3	NEK9 HERC1	5.36e-03	21	98	2	PS50012
Domain	RhoGEF	FGD4 AKAP13 PREX1	5.49e-03	68	98	3	SM00325
Domain	-	DEPTOR WRN CUL5 PREX1 KDM1A	5.84e-03	218	98	5	1.10.10.10
Domain	DEP	DEPTOR PREX1	5.88e-03	22	98	2	PF00610
Domain	DEP	DEPTOR PREX1	5.88e-03	22	98	2	PS50186
Domain	-	NEK9 HERC1	5.88e-03	22	98	2	2.130.10.30
Domain	Reg_chr_condens	NEK9 HERC1	5.88e-03	22	98	2	IPR000408
Domain	DEP	DEPTOR PREX1	5.88e-03	22	98	2	SM00049
Domain	RhoGEF	FGD4 AKAP13 PREX1	5.95e-03	70	98	3	PF00621
Domain	CH	SYNE1 CNN2 CNN3	5.95e-03	70	98	3	PF00307
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	2.85e-08	17	79	5	MM14552
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	3.93e-08	18	79	5	M524
Pathway	KEGG_ABC_TRANSPORTERS	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	4.45e-06	44	79	5	M11911
Pathway	REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES	MTHFD1L DHFR DHFR2	1.09e-04	17	79	3	M27085
Pathway	REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES	MTHFD1L DHFR DHFR2	2.09e-04	21	79	3	MM14763
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	2.31e-04	99	79	5	MM14986
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_ATTACHMENT_AND_ENTRY	GPC6 IGF1R TLR4	2.77e-04	23	79	3	M48234
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCA3 ABCA12 ABCA7 ABCG4 ABCG1	2.77e-04	103	79	5	M758
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEFSEC SUPT20H MTHFD1L SYNE1 WRN DYRK1A THOC3 TRRAP KIF20B DHX8 CELSR1 FGD4 ASCC3 SEC63 HEATR5B PREX1 KDM1A	1.06e-06	1497	99	17	31527615
Pubmed	Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.	ABCA3 ABCA12 ABCA7	1.24e-06	8	99	3	24293640
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 SUPT20H MTHFD1L THOC3 TRRAP VPS13D IGF1R HERC1 ASCC3 KDM1A	1.62e-06	497	99	10	36774506
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	DEPTOR ITGA3 NEK9 PRDM6	2.37e-06	33	99	4	30783098
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SUPT20H MTHFD1L WRN APBA2 THOC3 TRRAP POLR3A DHX8 NUP205 CUL5 UCHL1 UCHL3 ASCC3	5.65e-06	1005	99	13	19615732
Pubmed	A multipoint genetic linkage map of mouse chromosome 18.	CSF1R DHFR DHFR2	7.96e-06	14	99	3	1354640
Pubmed	Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.	IGF1R DHFR DHFR2	7.96e-06	14	99	3	1354647
Pubmed	Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.	ABCG4 ABCG1	8.02e-06	2	99	2	15240127
Pubmed	TLR4 mediates high-fat diet induced physiological changes in mice via attenuating PPARγ/ABCG1 signaling pathway.	ABCG1 TLR4	8.02e-06	2	99	2	30007438
Pubmed	Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy.	UCHL1 UCHL3	8.02e-06	2	99	2	17071595
Pubmed	Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis.	UCHL1 UCHL3	8.02e-06	2	99	2	15466400
Pubmed	Functional Cooperativity between ABCG4 and ABCG1 Isoforms.	ABCG4 ABCG1	8.02e-06	2	99	2	27228027
Pubmed	The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis.	UCHL1 UCHL3	8.02e-06	2	99	2	16508210
Pubmed	Genetic polymorphisms associated with sulphadoxine-pyrimethamine drug resistance among Plasmodium falciparum field isolates in malaria endemic areas of Assam.	DHFR DHPS	8.02e-06	2	99	2	25511211
Pubmed	Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation.	UCHL1 UCHL3	8.02e-06	2	99	2	21751213
Pubmed	Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.	UCHL1 UCHL3	8.02e-06	2	99	2	21678411
Pubmed	LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL.	ABCG4 ABCG1	8.02e-06	2	99	2	16556852
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.	ABCG4 ABCG1	8.02e-06	2	99	2	18039927
Pubmed	dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo.	DHFR DHPS	8.02e-06	2	99	2	19055622
Pubmed	Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.	UCHL1 UCHL3	8.02e-06	2	99	2	11555633
Pubmed	Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells.	IGF1R PREX1	8.02e-06	2	99	2	23899556
Pubmed	Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.	SYNE1 GPC6 PREX1	1.48e-05	17	99	3	17903302
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCA3 ABCA7 ABCG4 ABCG1 UCHL1 UCHL3	1.97e-05	193	99	6	19343046
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DEPTOR LRRC8D ITPR1 VPS13D AGO1 LRRC8A PDP2 ETNK1 CNN3	2.32e-05	536	99	9	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DEPTOR LRRC8D ITPR1 VPS13D AGO1 LRRC8A PDP2 ETNK1 CNN3	2.39e-05	538	99	9	10512203
Pubmed	Translocation of a long amino-terminal domain through ER membrane by following signal-anchor sequence.	DHFR DHFR2	2.40e-05	3	99	2	16107879
Pubmed	An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria.	DHFR DHFR2	2.40e-05	3	99	2	25980602
Pubmed	Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.	UCHL1 UCHL3	2.40e-05	3	99	2	32865982
Pubmed	Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice.	TLR4 KDM1A	2.40e-05	3	99	2	35775122
Pubmed	Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.	DHFR DHFR2	2.40e-05	3	99	2	26830229
Pubmed	Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria.	DHFR DHFR2	2.40e-05	3	99	2	22993211
Pubmed	New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.	DHFR DHFR2	2.40e-05	3	99	2	17019704
Pubmed	Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.	DHFR DHFR2	2.40e-05	3	99	2	21402147
Pubmed	Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation.	UCHL1 UCHL3	2.40e-05	3	99	2	21453705
Pubmed	Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain.	ABCG1 TLR4	2.40e-05	3	99	2	33970188
Pubmed	ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane.	ABCG4 ABCG1	2.40e-05	3	99	2	25302608
Pubmed	Transgenic mice expressing the tyr22 variant of murine DHFR: protection of transgenic marrow transplant recipients from lethal doses of methotrexate.	DHFR DHFR2	2.40e-05	3	99	2	9357973
Pubmed	Gene amplification and drug resistance in cultured murine cells.	DHFR DHFR2	2.40e-05	3	99	2	715457
Pubmed	ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.	ABCG4 ABCG1	2.40e-05	3	99	2	27196068
Pubmed	Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.	DHFR DHFR2	2.40e-05	3	99	2	6282858
Pubmed	ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa.	ABCA7 ABCG1	2.40e-05	3	99	2	18793613
Pubmed	The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter.	DHFR DHFR2	2.40e-05	3	99	2	1545788
Pubmed	Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases.	UCHL1 UCHL3	2.40e-05	3	99	2	9521656
Pubmed	Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction.	DHFR DHFR2	2.40e-05	3	99	2	30954686
Pubmed	Assignment of the human dihydrofolate reductase gene to the q11----q22 region of chromosome 5.	DHFR DHFR2	2.40e-05	3	99	2	6504041
Pubmed	The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional.	DHFR DHFR2	2.40e-05	3	99	2	21876184
Pubmed	Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.	UCHL1 UCHL3	2.40e-05	3	99	2	16402389
Pubmed	Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions.	ABCG1 TLR4	2.40e-05	3	99	2	18852364
Pubmed	Transcriptional regulation of the dihydrofolate reductase/rep-3 locus.	DHFR DHFR2	2.40e-05	3	99	2	7987046
Pubmed	The amino acid sequence of dihydrofolate reductase from the mouse lymphoma L1210.	DHFR DHFR2	2.40e-05	3	99	2	762074
Pubmed	CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4.	IGF1R TLR4	2.40e-05	3	99	2	29137928
Pubmed	Assignment of two rat dihydrofolate (DHFR) genes to chromosomes 2 and 4.	DHFR DHFR2	2.40e-05	3	99	2	2323224
Pubmed	Dihydrofolate reductase deficiency causing megaloblastic anemia in two families.	DHFR DHFR2	2.40e-05	3	99	2	1060915
Pubmed	The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.	WRN TERF1	2.40e-05	3	99	2	15200954
Pubmed	New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13.	DHFR DHFR2	2.40e-05	3	99	2	8903722
Pubmed	Ubiquitin dimers control the hydrolase activity of UCH-L3.	UCHL1 UCHL3	2.40e-05	3	99	2	19154770
Pubmed	Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells.	DHFR DHFR2	2.40e-05	3	99	2	2263462
Pubmed	Isolation and expression of an altered mouse dihydrofolate reductase cDNA.	DHFR DHFR2	2.40e-05	3	99	2	6573667
Pubmed	Expression and amplification of engineered mouse dihydrofolate reductase minigenes.	DHFR DHFR2	2.40e-05	3	99	2	6835212
Pubmed	LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.	LRRC8D LRRC8A	2.40e-05	3	99	2	29773801
Pubmed	Unbalanced growth in mouse cells with amplified dhfr genes.	DHFR DHFR2	2.40e-05	3	99	2	9650531
Pubmed	Structure and genomic organization of the mouse dihydrofolate reductase gene.	DHFR DHFR2	2.40e-05	3	99	2	6244105
Pubmed	Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.	DHFR DHFR2	2.40e-05	3	99	2	360074
Pubmed	Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.	DHFR DHFR2	2.40e-05	3	99	2	627542
Pubmed	In vitro mutations in dihydrofolate reductase that confer resistance to methotrexate: potential for clinical application.	DHFR DHFR2	2.40e-05	3	99	2	9554740
Pubmed	A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development.	CNN2 CNN3	2.40e-05	3	99	2	26046660
Pubmed	Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.	DHFR DHFR2	2.40e-05	3	99	2	13710631
Pubmed	Influence of substrate binding on the mechanical stability of mouse dihydrofolate reductase.	DHFR DHFR2	2.40e-05	3	99	2	16183885
Pubmed	ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.	ABCG4 ABCG1	2.40e-05	3	99	2	16902247
Pubmed	Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation.	ABCA3 ABCG1	2.40e-05	3	99	2	28241820
Pubmed	Nucleotide sequence surrounding multiple polyadenylation sites in the mouse dihydrofolate reductase gene.	DHFR DHFR2	2.40e-05	3	99	2	6121807
Pubmed	Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids.	DHFR DHFR2	2.40e-05	3	99	2	6272123
Pubmed	ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2.	ABCG4 ABCG1	2.40e-05	3	99	2	17916878
Pubmed	Defining the membrane proteome of NK cells.	MTHFD1L RPS4Y1 LRRC8D POLR3A ITPR1 NUP205 LRRC8A ETNK1 AKAP13 ASCC3 HEATR5B CNN2 PSD4	2.76e-05	1168	99	13	19946888
Pubmed	Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.	IGF1R DHFR DHFR2	2.87e-05	21	99	3	1347472
Pubmed	Differential expression and function of ABCG1 and ABCG4 during development and aging.	CYP46A1 ABCG4 ABCG1	3.31e-05	22	99	3	19633360
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCA3 ABCA7 ABCG1	3.80e-05	23	99	3	10708515
Pubmed	TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.	TRIM49 DEPTOR CUL5	4.34e-05	24	99	3	27693506
Pubmed	Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions.	DHFR DHFR2	4.79e-05	4	99	2	2982814
Pubmed	Analysis of the mouse Dhfr/Rep-3 major promoter region by using linker-scanning and internal deletion mutations and DNase I footprinting.	DHFR DHFR2	4.79e-05	4	99	2	2233729
Pubmed	The functional human dihydrofolate reductase gene.	DHFR DHFR2	4.79e-05	4	99	2	6323448
Pubmed	IL9 maps to mouse chromosome 13 and human chromosome 5.	DHFR DHFR2	4.79e-05	4	99	2	1970335
Pubmed	Cleavage of the C-terminus of NEDD8 by UCH-L3.	UCHL1 UCHL3	4.79e-05	4	99	2	9790970
Pubmed	Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome.	UCHL1 UCHL3	4.79e-05	4	99	2	28338014
Pubmed	The critical role of ABCG1 and PPARγ/LXRα signaling in TLR4 mediates inflammatory responses and lipid accumulation in vascular smooth muscle cells.	ABCG1 TLR4	4.79e-05	4	99	2	27807703
Pubmed	Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.	UCHL1 UCHL3	4.79e-05	4	99	2	32486284
Pubmed	Analysis of the human VPS13 gene family.	VPS13D VPS13B	4.79e-05	4	99	2	15498460
Pubmed	LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.	LRRC8D LRRC8A	4.79e-05	4	99	2	26824658
Pubmed	Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.	DHFR DHFR2	4.79e-05	4	99	2	26381869
Pubmed	Assignment of genes encoding dihydrofolate reductase and hexosaminidase B to Mus musculus chromosome 13.	DHFR DHFR2	4.79e-05	4	99	2	2947337
Pubmed	K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.	UCHL1 UCHL3	4.79e-05	4	99	2	33238157
Pubmed	The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.	ABCG4 ABCG1	4.79e-05	4	99	2	31159502
Pubmed	Characterization and chromosome location of the mouse link protein gene (Crtl1).	DHFR DHFR2	4.79e-05	4	99	2	10640815
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins.	ABCG4 ABCG1	4.79e-05	4	99	2	15210959
Pubmed	Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene.	DHFR DHFR2	4.79e-05	4	99	2	2722860
Pubmed	Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.	DHFR DHFR2	4.79e-05	4	99	2	20424322
Pubmed	Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene.	DHFR DHFR2	4.79e-05	4	99	2	2674679
Pubmed	Cell adhesion to substratum and activation of tyrosine kinases are essentially required for G1/S phase transition in BALB/c 3T3 fibroblasts.	DHFR DHFR2	4.79e-05	4	99	2	8611632
Pubmed	Protein unfolding and degradation by the AAA+ Lon protease.	DHFR DHFR2	4.79e-05	4	99	2	22162032
Pubmed	Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases.	UCHL1 UCHL3	4.79e-05	4	99	2	22284438
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA12 ABCA7	2.32e-05	14	74	3	805
GeneFamily	Parkinson disease associated genes\|Ubiquitin C-terminal hydrolases	UCHL1 UCHL3	9.86e-05	4	74	2	998
GeneFamily	Blood group antigens\|CD molecules\|ATP binding cassette subfamily G	ABCG4 ABCG1	1.64e-04	5	74	2	811
GeneFamily	Volume regulated anion channel subunits	LRRC8D LRRC8A	1.64e-04	5	74	2	1158
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	SUPT20H TRRAP	2.16e-03	17	74	2	1059
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD4 AKAP13 PREX1	2.50e-03	66	74	3	722
Coexpression	GSE21670_UNTREATED_VS_IL6_TREATED_CD4_TCELL_DN	SYNE1 ABCG1 VPS13D PLCL2 LRRC8A PREX1 CNN2	1.04e-05	200	98	7	M7441
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TUT4 SUPT20H WRN DYRK1A TERF1 TRRAP KIF20B ITPR1 ATP6V1H IGF1R AKAP13 ASCC3 VPS13B	1.82e-05	856	98	13	M4500
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000	RALGAPA1 TUT4 GPC6 KIF20B CUL5 STXBP6 AKAP13	3.91e-06	146	94	7	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000	RALGAPA1 BDP1 ABCA3 TUT4 GPC6 LRRC8D ITPR1 CUL5 CELSR1 STXBP6 FGD4 ETNK1 ASCC3	3.59e-05	774	94	13	gudmap_developingKidney_e15.5_cortic collect duct_1000
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ITGA3 NPFFR2 CELSR1 FGD4 ALPK2	2.39e-06	172	99	6	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ITGA3 NPFFR2 CELSR1 FGD4 ALPK2	2.39e-06	172	99	6	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SCN11A DEPTOR APBA2 DNAH14 DAAM2 RP2	3.42e-06	183	99	6	1464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CILP SYNE1 GPC6 ITPR1 DAAM2 PRDM6	3.75e-06	186	99	6	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	GPC6 IGF1R FGD4 DHFR AKAP13 VPS13B	4.50e-06	192	99	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CSF1R FGD4 TLR4 AKAP13 PREX1 ALPK2	5.22e-06	197	99	6	b597c292fc1cb381a4325fed15a32966c38def28
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	RALGAPA1 DEPTOR APBA2 NEK9 ITPR1 CSF1R KCNJ5	1.44e-05	183	98	7	5599_UP
Drug	NSC-107146	DHFR DHFR2	1.83e-05	2	98	2	CID000267616
Drug	gamma-tBAMT	DHFR DHFR2	1.83e-05	2	98	2	CID000125341
Drug	deaza-aminopterin	SYNE1 DHFR	1.83e-05	2	98	2	CID000101200
Drug	DPCO	DHPS AKAP13	1.83e-05	2	98	2	CID000126454
Drug	aditoprim	DHFR DHFR2	1.83e-05	2	98	2	CID000068755
Drug	2,4-diamino-5-benzylpyrimidine	DHFR DHFR2	1.83e-05	2	98	2	CID000081752
Drug	methotrexate-alpha-aspartate	DHFR DHFR2	1.83e-05	2	98	2	CID000100376
Drug	ethyl isocyanatoacetate	DHFR DHFR2	1.83e-05	2	98	2	CID000076283
Drug	3'-fluoroaminopterin	DHFR DHFR2	1.83e-05	2	98	2	CID000128780
Drug	DIVEMA-MTX	DHFR DHFR2	1.83e-05	2	98	2	CID000430857
Drug	4-ethylacetophenone	DHFR DHFR2	1.83e-05	2	98	2	CID000013642
Drug	2,4-diamino-5-phenylpyrimidine	DHFR DHFR2	1.83e-05	2	98	2	CID000134761
Drug	Trimipramine maleate salt [521-78-8]; Down 200; 9.8uM; MCF7; HT_HG-U133A	TUT4 APBA2 NEK9 VPS13D AGO1 KCNJ5 PSD4	2.25e-05	196	98	7	3342_DN
Drug	Methionine sulfoximine (L) [15985-39-4]; Down 200; 22.2uM; MCF7; HT_HG-U133A	CILP RPS4Y1 DYRK1A ITPR1 UCHL1 KCNJ5 HNRNPA0	2.25e-05	196	98	7	4151_DN
Drug	estradiol, USP; Up 200; 0.01uM; PC3; HT_HG-U133A	SUPT20H ABCG1 VPS13D STXBP6 KCNJ5 AKAP13 PSD4	2.40e-05	198	98	7	1241_UP
Drug	Lidoflazine [3416-26-0]; Up 200; 8.2uM; MCF7; HT_HG-U133A	SCN11A TUT4 CILP APBA2 CSF1R DAAM2 BAHCC1	2.48e-05	199	98	7	6278_UP
Drug	Metformin hydrochloride [1115-70-4]; Up 200; 24.2uM; MCF7; HT_HG-U133A	RALGAPA1 DYRK1A ITPR1 KCNJ5 PLCL2 VPS13B CNN3	2.56e-05	200	98	7	5487_UP
Drug	dihydropteroate	DHFR DHFR2 DHPS	3.39e-05	15	98	3	CID000000170
Drug	DHFR inhibitor	DHFR DHFR2 DHPS	3.39e-05	15	98	3	CID000041526
Drug	chloromethyl pivalate	DHFR DHFR2	5.49e-05	3	98	2	CID000087885
Drug	diethyl N-(4-aminobenzoyl)-L-glutamate	SYNE1 DHFR	5.49e-05	3	98	2	CID000073002
Drug	10-propargylaminopterin	SYNE1 DHFR2	5.49e-05	3	98	2	CID000100093
Drug	5,10-dideazaaminopterin	SYNE1 DHFR	5.49e-05	3	98	2	CID000125704
Drug	F2Glu	DHFR DHFR2	5.49e-05	3	98	2	CID000125424
Drug	2,4,5,6-Tetraaminopyrimidine sulfate	DHFR DHFR2	5.49e-05	3	98	2	CID000070487
Drug	GNF-Pf-26	DHFR DHFR2	5.49e-05	3	98	2	CID000093114
Drug	diaveridine	DHFR DHFR2	5.49e-05	3	98	2	CID000021453
Drug	I--254	DHFR DHFR2	5.49e-05	3	98	2	CID000032285
Drug	8-deazahomofolic acid	DHFR DHFR2	5.49e-05	3	98	2	CID000130665
Drug	chloroformamidine hydrochloride	DHFR DHFR2	5.49e-05	3	98	2	CID003084509
Drug	DMDP derivative	DHFR DHFR2	5.49e-05	3	98	2	CID000482165
Drug	MTX-gamma-DMPE	DHFR DHFR2	5.49e-05	3	98	2	CID000146936
Drug	dihydropteroylhexaglutamate	DHFR DHFR2	5.49e-05	3	98	2	CID000193840
Drug	AC1NUZIC	DHFR DHPS	5.49e-05	3	98	2	CID005497118
Drug	5-deazaaminopterin	DHFR DHFR2	1.09e-04	4	98	2	CID000097272
Drug	AC1MQVYC	DHFR DHFR2	1.09e-04	4	98	2	CID003483303
Drug	methasquin	DHFR DHFR2	1.09e-04	4	98	2	CID000029335
Drug	ethyl 4-acetylbenzoate	DHFR DHFR2	1.09e-04	4	98	2	CID000600911
Drug	pY490	DHFR DHFR2	1.09e-04	4	98	2	CID000283017
Drug	K 130	DHFR DHFR2	1.09e-04	4	98	2	CID000467834
Drug	2,4-diamino-6-nitroquinazoline	DHFR DHFR2	1.09e-04	4	98	2	CID000252163
Drug	isofolic acid	SYNE1 DHFR	1.09e-04	4	98	2	CID000191247
Drug	pergularinine	DHFR DHFR2	1.09e-04	4	98	2	CID000264751
Drug	5,8-dideazafolic acid	DHFR DHFR2	1.09e-04	4	98	2	CID003080619
Drug	24-hydroxycholesterol	CYP46A1 ABCG1 TLR4	1.47e-04	24	98	3	ctd:C044563
Drug	sulfadoxine	DHFR DHFR2 DHPS	1.47e-04	24	98	3	CID000017134
Drug	lometrexol	SYNE1 DHFR DHFR2	1.66e-04	25	98	3	CID000001773
Drug	FAH2	MTHFD1L DHFR DHFR2 DHPS	1.68e-04	64	98	4	CID000000661
Drug	Corticosterone [50-22-6]; Up 200; 11.6uM; HL60; HT_HG-U133A	TUT4 SUPT20H IGF1R STXBP6 ETNK1 BAHCC1	1.69e-04	189	98	6	1307_UP
Drug	tylophorinidine	DHFR DHFR2	1.82e-04	5	98	2	CID000161749
Drug	piritrexim isethionate	DHFR DHFR2	1.82e-04	5	98	2	CID000054368
Drug	chlorasquin	DHFR DHFR2	1.82e-04	5	98	2	CID000029336
Drug	2-desamino-2-methylaminopterin	DHFR DHFR2	1.82e-04	5	98	2	CID000164085
Drug	deoxytubulosine	DHFR DHFR2	1.82e-04	5	98	2	CID000165003
Drug	methylbenzoprim	DHFR DHFR2	1.82e-04	5	98	2	CID000072438
Drug	Minaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	SCN11A ABCA7 ATP8B2 ITPR1 CSF1R DAAM2	2.00e-04	195	98	6	4814_UP
Drug	Timolol maleate salt [26921-17-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A	SCN11A NEK9 ITPR1 VPS13D TLR4 BAHCC1	2.06e-04	196	98	6	6483_UP
Drug	Sulfamethoxazole [723-46-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A	ITPR1 STXBP6 KCNJ5 DAAM2 BAHCC1 PSD4	2.06e-04	196	98	6	2296_UP
Drug	sulfamethoxazole	DHFR DHFR2 DHPS	2.10e-04	27	98	3	CID000005329
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	CILP ABCA7 ITPR1 KCNJ5 BAHCC1 PSD4	2.11e-04	197	98	6	3934_DN
Drug	Ajmaline [4360-12-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	SUPT20H APBA2 DYRK1A ABCA7 STXBP6 PSD4	2.11e-04	197	98	6	2899_DN
Drug	Vincamine [1617-90-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A	SCN11A RPS4Y1 APBA2 VPS13D CSF1R KCNJ5	2.17e-04	198	98	6	3865_UP
Drug	Chlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; MCF7; HT_HG-U133A	RALGAPA1 GPR50 RPS4Y1 CSF1R KCNJ5 PSD4	2.17e-04	198	98	6	1541_UP
Drug	troglitazone; Down 200; 10uM; MCF7; HT_HG-U133A_EA	ABCA3 KIF20B CUL5 ABCG1 VPS13D AGO1	2.17e-04	198	98	6	1070_DN
Drug	Bucladesine sodium salt [16980-89-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	IGF1R CSF1R KCNJ5 PLCL2 DAAM2 BAHCC1	2.17e-04	198	98	6	5886_UP
Drug	Zimelidine dihydrochloride monohydrate [61129-30-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	RALGAPA1 DEPTOR APBA2 VPS13D IGF1R CSF1R	2.17e-04	198	98	6	1512_UP
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Up 200; 9uM; MCF7; HT_HG-U133A	RPS4Y1 NEK9 VPS13D UCHL1 DAAM2 CNN3	2.17e-04	198	98	6	5628_UP
Drug	Eucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	RPS4Y1 DYRK1A ABCA7 KCNJ5 PLCL2 DAAM2	2.23e-04	199	98	6	3841_UP
Drug	Delsoline [509-18-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	APBA2 NEK9 ATP8B2 VPS13D CSF1R AKAP13	2.23e-04	199	98	6	6075_DN
Drug	estradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A	DYRK1A NEK9 CSF1R UCHL1 KCNJ5 PSD4	2.29e-04	200	98	6	5601_UP
Drug	N-Boc-ethylenediamine	EEFSEC SYNE1	2.72e-04	6	98	2	CID000187200
Drug	11-deazahomofolic acid	DHFR DHFR2	2.72e-04	6	98	2	CID000128960
Drug	10-methyl-11-deazahomofolic acid	DHFR DHFR2	2.72e-04	6	98	2	CID000128963
Drug	dihydrofolate	IGF1R DHFR	2.72e-04	6	98	2	ctd:C010920
Drug	NBMPR-P	DHFR DHFR2	2.72e-04	6	98	2	CID006335125
Drug	4-thio-5-fluoro-dUMP	DHFR DHFR2	2.72e-04	6	98	2	CID003035986
Drug	edatrexate	SYNE1 DHFR DHFR2	2.89e-04	30	98	3	CID000054586
Disease	blood pressure	SYNE1 GPC6 PREX1	4.76e-05	22	95	3	EFO_0004325
Disease	Global developmental delay	TRRAP IGF1R AGO1 DHPS KDM1A	7.22e-05	133	95	5	C0557874
Disease	Colorectal Neoplasms	ABCA3 ABCA12 SYNE1 ABCG1 DHFR TLR4	2.80e-04	277	95	6	C0009404
Disease	breast cancer (is_marker_for)	TUT4 TERF1 IGF1R CSF1R KDM1A	3.37e-04	185	95	5	DOID:1612 (is_marker_for)
Disease	lactosyl-N-nervonoyl-sphingosine (d18:1/24:1) measurement	ABCA7 CNN2	3.64e-04	9	95	2	EFO_0800517
Disease	red blood cell density measurement	RALGAPA1 ATP8B2 KIF20B NUP205 PLCL2 OR4C46 AKAP13 PREX1 VPS13B PSD4	5.43e-04	880	95	10	EFO_0007978
Disease	platelet component distribution width	EEFSEC SCN11A SUPT20H SYNE1 IGF1R DHPS AKAP13 HERC1 PREX1	7.42e-04	755	95	9	EFO_0007984
Disease	idiopathic pulmonary fibrosis	DEPTOR GPR157 AKAP13	8.34e-04	57	95	3	EFO_0000768
Disease	diabetic neuropathy (implicated_via_orthology)	IGF1R TLR4	9.10e-04	14	95	2	DOID:9743 (implicated_via_orthology)
Disease	feeling "fed-up" measurement	TLR4 PLCL2 OR4C46	1.92e-03	76	95	3	EFO_0009588
Disease	Colorectal Carcinoma	ABCA3 ABCA12 MTHFD1L SYNE1 WRN ABCG1 DHFR TLR4	1.95e-03	702	95	8	C0009402
Disease	amblyopia	MALRD1 TLR4	2.27e-03	22	95	2	MONDO_0001020
Disease	sphingomyelin 24:1 measurement	CELSR1 IGF1R	2.48e-03	23	95	2	EFO_0010398
Disease	attempted suicide	HIBADH FER1L6 FGD4 PREX1	2.66e-03	178	95	4	EFO_0004321
Disease	serum gamma-glutamyl transferase measurement	DYRK1A ITPR1 IGF1R SPATA21 AKAP13 TSHZ1 ALPK2 KDM1A BAHCC1	2.75e-03	914	95	9	EFO_0004532
Disease	eosinophil percentage of leukocytes	DYRK1A ABCA7 NUP205 CELSR1 PLCL2 AKAP13 CNN2 ALPK2	2.83e-03	746	95	8	EFO_0007991
Disease	eosinophil count	EEFSEC CD177 DYRK1A NUP205 CELSR1 STXBP6 PLCL2 AKAP13 OR4C13 CNN2 ALPK2 BAHCC1	2.94e-03	1488	95	12	EFO_0004842
Disease	eye color	APBA2 NUP205 GPR157	3.10e-03	90	95	3	EFO_0003949
Disease	blood chromium measurement	GPC6 TSHZ1	3.17e-03	26	95	2	EFO_0007579
Disease	forced expiratory volume, response to bronchodilator	EEFSEC SYNE1 GPC6 NUP205 FGD4 PREX1	3.20e-03	445	95	6	EFO_0004314, GO_0097366

Protein segments in the cluster

Peptide	Gene	Start	Entry
CFQVVSLMKSLAQGG	ABCG4	236	Q9H172
GSQQGLCKVFEMIIN	AADAT	116	Q8N5Z0
TSCLLNTKVLNGEMG	BAHCC1	281	Q9P281
QMLSCTQNIDGIVGF	BDP1	516	A6H8Y1
FCQLEITLMGKQGSN	CUL5	111	Q93034
SCFQVVSLMKGLAQG	ABCG1	251	P45844
GNTNCKGEGMQVNTL	ALPK2	626	Q86TB3
IMVNGKFQCIGSLQH	ABCA12	2461	Q86UK0
TLLGMATQCVQVKNV	AGO1	536	Q9UL18
GCTGPIFKLMNIQQQ	AKAP13	271	Q12802
IMVQGQFKCLGSPQH	ABCA3	1586	Q99758
GQTEVGMICANQKGQ	ACSM4	371	P0C7M7
LGFSVQNGIICSLMR	APBA2	671	Q99767
GGLSTKMSIQGCVAQ	CD177	361	Q8N6Q3
QFVGCMRNLSVDGKN	CELSR1	1616	Q9NYQ6
GGCALMNRSTKFQQI	DUS3L	406	Q96G46
GVSLNLTRKFAQQMC	DYRK1A	256	Q13627
TQQGFGNLPICMAKT	MTHFD1L	896	Q6UB35
SFGQRQSCQGMVIVK	CDHR4	211	A6H8M9
LTCINLFIGINGSMA	ABCA7	1651	Q8IZY2
LTQNIMVFNKCSING	ATP8B2	416	P98198
GNTMCKISGLVQGIS	NPFFR2	216	Q9Y5X5
QSISQKLMAGFVECL	NUP205	941	Q92621
QAILGSIVNAFMVGC	KCNJ5	171	P48544
FGGTLQVTQDKMICL	LRRC8A	41	Q8IWT6
GVSRCKTNGMQAFSQ	C8orf88	46	P0DMB2
SLIGCIKALMNNSQG	DAAM2	176	Q86T65
CGNVKVNAIYGLMVA	OR52N4	191	Q8NGI2
NLLGVIFMKGNCATE	MAGEB3	206	O15480
FNKLGLNQCMSGIIN	NEK9	561	Q8TD19
CNKIIFLMSFVGNCG	ITPR1	2371	Q14643
NTQVCVTGNGMFKLL	CFAP57	166	Q96MR6
LQGMFIRKVCAGSQS	HERC1	611	Q15751
LSQLQCQMVGFITGL	GPR50	96	Q13585
SAQMLQGCTIFKGNL	IGF1R	346	P08069
MCQLGTSGGFTQNTV	ITGA3	196	P26006
GKKAILFNGCMTQVF	OR4C46	86	A6NHA9
KTQGAQTCVANGVMA	FGD4	81	Q96M96
PATTQKEFFQGCIMQ	KIF20B	121	Q96Q89
QSFFNGKGKICMIVN	KIF20B	441	Q96Q89
ENKTILFNGCMTQVF	OR4C13	86	Q8NGP0
LQIQKFVNMKTQGCF	GTPBP8	241	Q8N3Z3
GQCFKTFTQRILLQM	PRDM6	476	Q9NQX0
FSCQVSGKLMVGLQT	MALRD1	151	Q5VYJ5
VASCLQTNGLMFGIF	PDP2	126	Q9P2J9
QVAQGMAFLASKNCI	CSF1R	761	P07333
IGVQSLQNGCMNRFK	HEATR5B	1876	Q9P2D3
MQVSAKVFQGCGQPK	GPC6	331	Q9Y625
VQRMGFGNLNKVVLC	KDM1A	651	O60341
SCIGQQFAQMEVKVV	CYP46A1	436	Q9Y6A2
INTQAIFAKCTGMII	DHPS	266	P49366
NCIVAVSQNMGIGKN	DHFR	6	P00374
MKVCQFVVSVNGLNV	DEPTOR	366	Q8TB45
IGNTFQGGANCIMFV	GPR157	266	Q5UAW9
NAMKTGGSVLLQSCQ	DNAH14	2561	Q0VDD8
NCIVAVSQNMGIGKN	DHFR2	6	Q86XF0
GITNKLIGCYVGNTM	ETNK1	146	Q9HBU6
TGQFCMIQTLKKGQT	BVES	146	Q8NE79
KVTSIMQFGCFVQLE	DHX8	271	Q14562
FAGTMQLTKDQVVCL	LRRC8D	41	Q7L1W4
LLQQKRISFVGCMTQ	OR6B2	86	Q6IFH4
FAGQMGRTTVQKNCA	FER1L6	286	Q2WGJ9
MNSGILQVFQGELIC	TRIM49	1	P0CI25
CIMGVLSNKCGFQLQ	ATP6V1H	226	Q9UI12
QSLGNFRQGFMKCLL	SPATA21	76	Q7Z572
NNLQMKGDTLIGQCA	SYNE1	3981	Q8NF91
NMQNAVVSFKELCGL	PLCL2	936	Q9UPR0
GQNIGKSMSCQEFIT	PSD4	696	Q8NDX1
KSMSCQEFITNLNGL	PSD4	701	Q8NDX1
CAGQCILKVNGSNVM	PREX1	746	Q8TCU6
KGSFINISQMIACVG	POLR3A	786	O14802
NFIKFDTGNLCMVIG	RPS4Y1	171	P22090
QCVIATIAFGMGINK	WRN	816	Q14191
LLQQKRISFVGCMTQ	OR6B3	86	Q8NGW1
AVGTGQAAKICNNML	HIBADH	201	P31937
FFNKIQASLGGCVRM	ACSL6	416	Q9UKU0
LGQTFLGIKCANKMQ	ASCC3	681	Q8N3C0
IMKSNVGVALTFNCV	CILP	1106	O75339
IGLQMGTNKCASQSG	CNN2	166	Q99439
ISLQMGTNKCASQVG	CNN2	206	Q99439
QSVIGLQMGTNKCAS	CNN3	161	Q15417
FCLKTHMRVQNGGNT	ZNF561	131	Q8N587
FMKQTISNACGTIGL	UCHL3	86	P15374
KGMQTQSAECLVIGQ	EEFSEC	121	P57772
FINCQSKIMGGNSIL	STXBP6	141	Q8NFX7
QATGQGICIAFKDIM	TAS1R1	231	Q7RTX1
VNLTNHCGFMGGLQK	RALGAPA1	1846	Q6GYQ0
MENSQLCKLFIGGLN	HNRNPA0	1	Q13151
MNSGILQVFQGELIC	TRIM49C	1	P0CI26
FINVVGSVCGAQALM	SUPT20H	546	Q8NEM7
MFFLTNGNGCINILS	THOC3	196	Q96J01
CQLIVNEIFNGTKMF	RP2	311	O75695
CMKLSQMAVQGLQQF	SEC63	366	Q9UGP8
IKIQAIAVCMENGNF	TERF1	176	P54274
KLCQFCISSMVQQGI	VPS13B	3086	Q7Z7G8
GQQLFMGSLNLKCIS	SCN11A	271	Q9UI33
VKSNNMATNGCILLG	TUT4	736	Q5TAX3
NFDSLNVMKTCIQGL	TLR4	236	O00206
QQVKCYLQLAGVMGK	TRRAP	3081	Q9Y4A5
AKVTNGCNNLGIIMD	TSHZ1	721	Q6ZSZ6
FMKQTIGNSCGTIGL	UCHL1	81	P09936
VFFCQMGKRGLQATQ	TSTD1	76	Q8NFU3
AFGICIKNVSMQNAV	VPS13D	171	Q5THJ4